Selleck Chemicals - Products
United States; Europe
Selleck Chemicals supplies bioactive small molecules, inhibitors, compound libraries, antibodies, natural products and related research reagents for life science research.
| Product | Description | |
|---|---|---|
| TLR4 Antibody [J3D3] | TLR4,Toll-like Receptor 4. Group: Antibodies. Alternative Names: TLR4,Toll-like Receptor 4. Pack Sizes: 20uL. Product ID: F2122. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. |  United States; Europe |
| TMZ(Temozolomide) | TMZ(Temozolomide) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210 / BCNU cells. Temozolomide induces apoptosis and exhibits antitumor activity. Group: Inhibitors. Alternative Names: NSC 362856,CCRG 81045,Methazolastone. CAS No. 85622-93-1. Pack Sizes: 25mg. Product ID: S1237. Formula: C6H6N6O2. Smiles: CN1C(=O)N2C=NC(=C2N=N1)C(=O)N. Storage Conditions: (in dark and seal) . | United States; Europe |
| Tocilizumab (anti-IL-6R) | Tocilizumab (anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor, MW: 148 KD. Group: Antibodies. Alternative Names: MRA. CAS No. ?375823-41-9. Pack Sizes: 5mg. Product ID: A2012. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| Tofacitinib (CP-690550) | Tofacitinib is a novel inhibitor of JAK3 with IC50 of 1 nM in cell-free assays, 20- to 100-fold less potent against JAK2 and JAK1. Tofacitinib inhibits the expression of antiapoptotic BCL-A1 and BCL-XL in human plasmacytoid dendritic cells (PDC) and induced PDC apoptosis. Group: Inhibitors. Alternative Names: CP-690550, Tasocitinib. CAS No. 477600-75-2. Pack Sizes: 5mg. Product ID: S2789. Formula: C16H20N6O. Smiles: CC1CCN(CC1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| TOMM20 Antibody [H21N23] | Tom20,TOMM20. Group: Antibodies. Alternative Names: Tom20,TOMM20. Pack Sizes: 20ul. Product ID: F0513. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Topotecan (SKF 104864A) | Topotecan(NSC609699,Nogitecan,SKFS 104864A) is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases. Group: Inhibitors. Alternative Names: NSC609699,Nogitecan,SKFS 104864A. CAS No. 123948-87-8. Pack Sizes: 25mg. Product ID: S9321. Formula: C23H23N3O5. Smiles: CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Torin 1 | Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K. Group: Inhibitors. CAS No. 1222998-36-8. Pack Sizes: 10mg. Product ID: S2827. Formula: C35H28F3N5O2. Smiles: CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| TPCA-1 | TPCA-1 (GW683965) is an inhibitor of IKK-2 with IC50 of 17.9 nM in a cell-free assay, inhibits NF-κB pathway, exhibits 22-fold selectivity over IKK-1. TPCA-1 is also an inhibitor of STAT3 and enhances apoptosis. Group: Inhibitors. Alternative Names: GW683965. CAS No. 507475-17-4. Pack Sizes: 10mg. Product ID: S2824. Formula: C12H10FN3O2S . Smiles: C1=CC(=CC=C1C2=CC(=C(S2)NC(=O)N)C(=O)N)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Trametinib (GSK1120212) | Trametinib (GSK1120212, JTP-74057) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. Trametinib activates autophagy and induces apoptosis. Group: Inhibitors. Alternative Names: JTP-74057. CAS No. 871700-17-3. Pack Sizes: 5mg. Product ID: S2673. Formula: C26H23FIN5O4. Smiles: CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Trastuzumab (anti-HER2) | Trastuzumab (anti-human HER2) is a humanized, recombinant monoclonal antibody that binds to the extracellular domain of HER2, MW:145.53 KD. Group: Antibodies. CAS No. 180288-69-1. Pack Sizes: 5mg. Product ID: A2007. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| Trastuzumab deruxtecan (DS-8201a, T-DXd) | Trastuzumab deruxtecan (DS-8201a, T-DXd) is an antibody-drug conjugate (ADC) composed of an anti-HER2 (human epidermal growth factor receptor 2) antibody and a cytotoxic topoisomerase I inhibitor. Trastuzumab deruxtecan shows durable antitumor activity. Trastuzumab deruxtecan has a molecular weight of 153KDa. Alternative Names: DS-8201. CAS No. 1826843-81-5. Pack Sizes: 1mg. Product ID: D4001. Formula: 7.8. Storage Conditions: Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| Trastuzumab Emtansine?T-DM1? | Trastuzumab Emtansine(T-DM1,Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1.Trastuzumab emtansine has a molecular weight of 145kDa.This product is supplied as 10mg/ml PBS solution. Alternative Names: Ado-Trastuzumab emtansine. CAS No. 1018448-65-1. Pack Sizes: 1mg. Product ID: D4003. Formula: 3.6. Storage Conditions: Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| Trichostatin A (TSA) | TSA (Trichostatin A) is an HDAC inhibitor with IC50 of ~1.8 nM in cell-free assays. Group: Inhibitors. CAS No. 58880-19-6. Pack Sizes: 5mg. Product ID: S1045. Formula: C17H22N2O3. Smiles: CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Triptolide | Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein. Triptolide (PG490) abrogates the transactivation function of heat shock transcription factor 1 (HSF1). Triptolide inhibits MDM2 and induces apoptosis through a p53-independent pathway. Group: Inhibitors. Alternative Names: PG490, NSC 163062. CAS No. 38748-32-2. Pack Sizes: 1mg. Product ID: S3604. Formula: C20H24O6. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| TRPV1 C- terminal Antibody [G12G6] | TRPV1,Vanilloid R1/TRPV1. Group: Antibodies. Alternative Names: TRPV1,Vanilloid R1. Pack Sizes: 20uL. Product ID: F2733. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| TRULI (Lats-IN-1) | TRULI inhibits both Lats1 and Lats2 with a IC50 of 0.2?nM, suppresses Yap phosphorylation, induces cell proliferation in several cell lines and tissues, and promotes the initial stages of proliferative regeneration of the sensory receptors in the inner ear. Group: Inhibitors. CAS No. 1424635-83-5. Pack Sizes: 5mg. Product ID: E1061. Formula: C18H14N4OS. Smiles: O=C(N=C1SC=CN1CC2=CC=CC=C2)C3=C[NH]C4=NC=CC=C34. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| TSG101 Antibody [B19D18] | tsg 101,TSG101. Group: Antibodies. Alternative Names: Tumor susceptibility gene 101 protein, ESCRT-I complex subunit TSG101. CAS No. Pack Sizes: 20uL. Product ID: F1543. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| TTNPB (Arotinoid acid) | TTNPB is a potent RAR agonist, and inhibits binding of [3H]tRA with IC50 of 5.1 nM, 4.5 nM, and 9.3 nM for human RARα, β, and γ, respectively. Group: Inhibitors. Alternative Names: Arotinoid Acid, Ro 13-7410, AGN-191183. CAS No. 71441-28-6. Pack Sizes: 10mg. Product ID: S4627. Formula: C24H28O2. Smiles: CC(=CC1=CC=C(C=C1)C(=O)O)C2=CC3=C(C=C2)C(CCC3(C)C)(C)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Tubastatin A | Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). Tubastatin A promotes autophagy and increases apoptosis. Group: Inhibitors. CAS No. 1252003-15-8. Pack Sizes: 50mg. Product ID: S8049. Formula: C20H21N3O2. Smiles: CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=C(C=C4)C(=O)NO. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Tucatinib (Irbinitinib, ONT-380, Arry-380) | Tucatinib (Irbinitinib, ONT-380, ARRY-380) is an oral, potent, selective, reversible and ATP-competitive small-molecule inhibitor of ErbB-2 (also called HER2) with IC50s of 8 nM and 7 nM for ErbB-2 and p95 HER2, respectively in cell-based assays, showing ~500-fold selective for HER2 vs EGFR. It has potential antineoplastic activity. Group: Inhibitors. Alternative Names: Irbinitinib, ONT-380, ARRY-380. CAS No. 937263-43-9. Pack Sizes: 5mg. Product ID: S8362. Formula: C26H24N8O2. Smiles: CC1=C(C=CC(=C1)NC2=NC=NC3=C2C=C(C=C3)NC4=NC(CO4)(C)C)OC5=CC6=NC=NN6C=C5. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Tucidinostat (Chidamide) | Tucidinostat (Chidamide, HBI-8000, CS-055) is a low nanomolar inhibitor of HDAC1, 2, 3, and 10, the HDAC isotypes well documented to be associated with the malignant phenotype with IC50 values of 95, 160, 67, 78 nM for HDAC1, 2, 3, 10 respectively. Group: Inhibitors. Alternative Names: HBI-8000, CS-055. CAS No. 1616493-44-7. Pack Sizes: 5mg. Product ID: S8567. Formula: C22H19FN4O2. Smiles: C1=CC(=CN=C1)C=CC(=O)NCC2=CC=C(C=C2)C(=O)NC3=C(C=C(C=C3)F)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Tunicamycin | Tunicamycin, an antibiotic, can potently inhibit the N-linked glycosylation (NLG) by competitively inhibiting UDP-GlcNAc-dolichol-phosphate N-acetylglucosamine-1 phosphate transferase (DPAGT1) activity and can target several types of tumors by reducing angiogenesis, inhibiting colony formation, and enhancing TRAIL-induced apoptosis. Group: Inhibitors. CAS No. 11089-65-9. Pack Sizes: 5mg. Product ID: S7894. Formula: C37H60N4O16. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Tween 80 | Tween 80 is a polysorbate surfactant used for selective protein extraction and the isolation of nuclei from mammalian cell lines. Tween 80 has been used in drug vehicle solutions for specific injections in mice and rats. It has been used for the determination of esterase activity in bacterial cells. Group: Inhibitors. Alternative Names: Polysorbate 80. CAS No. 9005-65-6. Pack Sizes: 100mL. Product ID: S6702. Smiles: CCCCCCCCC=CCCCCCCCC(=O)OCCOCC(C1C(C(CO1)OCCO)OCCO)OCCO. Storage Conditions: 2 years room temperature liquid. | United States; Europe |
| Tyrosine Hydroxylase Antibody [F11M19] | TH,Tyrosine Hydrolase,Tyrosine Hydroxylase. Group: Antibodies. Alternative Names: TH,Tyrosine Hydrolase,Tyrosine Hydroxylase. CAS No. Pack Sizes: 20ul. Product ID: F0108. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| U0126-EtOH | U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity. Group: Inhibitors. CAS No. 1173097-76-1. Pack Sizes: 25mg. Product ID: S1102. Formula: C18H16N6S2.C2H6O. Smiles: CCO.C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| U-73122 | U73122 is a potent phospholipase C (PLC) inhibitor, which reduces agonist-induced Ca2+ increases in platelets and PMN. U73122 potently inhibits human 5-lipoxygenase (5-LO). Group: Inhibitors. CAS No. 112648-68-7. Pack Sizes: 5mg. Product ID: S8011. Formula: C29H40N2O3. Smiles: CC12CCC3C(C1CCC2NCCCCCCN4C(=O)C=CC4=O)CCC5=C3C=CC(=C5)OC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Ubiquitin Antibody [J9C13] | Ub,Ubiquitin,Ubiquitinylated proteins. Group: Antibodies. Alternative Names: Ub,Ubiquitin,Ubiquitinylated proteins. Pack Sizes: 20ul. Product ID: F0109. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Ubiquitin (linkage-specific Lys 63) Antibody [J20H12] | K63-linkage Specific Polyubiquitin,Ubiquitin (linkage-specific K63),Ub-K63. Group: Antibodies. Alternative Names: K63-linkage Specific Polyubiquitin,Ubiquitin (linkage-specific K63),Ub-K63. CAS No. Pack Sizes: 20uL. Product ID: F0528. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| UC2288 | UC2288 is a novel, cell-permeable, and orally active p21 attenuator, decreases p21 mRNA expression independently of p53, and attenuates p21 protein levels with minimal effect on p21 protein stability. Group: Inhibitors. CAS No. 1394011-91-6. Pack Sizes: 5mg. Product ID: E1190. Formula: C20H18ClF6N3O2. Smiles: FC(F)(F)C1=CC=C(OC2CCC(CC2)NC(=O)NC3=CC(=C(Cl)C=C3)C(F)(F)F)N=C1. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| UCP1 Antibody [L8P13] | UCP1,UCP-1. Group: Antibodies. Alternative Names: UCP-1. Pack Sizes: 20uL. Product ID: F0765. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| UK-5099 (PF-1005023) | UK5099 (PF-1005023) is a potent inhibitor of the mitochondrial pyruvate carrier, inhibiting pyruvate transport across the plasma membrane of trypanosomes with Ki value of 49 μM. Group: Inhibitors. Alternative Names: PF-1005023. CAS No. 56396-35-1. Pack Sizes: 10mg. Product ID: S5317. Formula: C18H12N2O2. Smiles: C1=CC=C(C=C1)N2C=C(C3=CC=CC=C32)C=C(C#N)C(=O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Ulixertinib (BVD-523) | Ulixertinib (BVD-523, VRT752271) is a potent and reversible ERK1/ERK2 inhibitor with IC50 of <0.3 nM for ERK2. Phase 1. Group: Inhibitors. Alternative Names: VRT752271. CAS No. 869886-67-9. Pack Sizes: 5mg. Product ID: S7854. Formula: C21H22Cl2N4O2. Smiles: CC(C)NC1=NC=C(C(=C1)C2=CNC(=C2)C(=O)NC(CO)C3=CC(=CC=C3)Cl)Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| UNC0638 | UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP histone methyltransferase with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 has anti-viral activities. Group: Inhibitors. CAS No. 1255580-76-7. Pack Sizes: 10mg. Product ID: S8071. Formula: C30H47N5O2. Smiles: CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)C5CCCCC5. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| UNC0642 | UNC0642 is a potent, selective inhibitor of histone methyltransferases G9a/GLP with IC50s less than 2.5 nM for G9a and GLP and shows more than 300-fold selective for G9a and GLP over a broad range of kinases, GPCRs, transporters, and ion channels. Group: Inhibitors. CAS No. 1481677-78-4. Pack Sizes: 5mg. Product ID: S7230. Formula: C29H44F2N6O2. Smiles: CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)N5CCC(CC5)(F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Urolithin A | Urolithin A (3,8-Dihydroxy Urolithin, 2',7-Dihydroxy-3,4-benzocoumarin), a metabolite of ellagitannin, is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption. Group: Inhibitors. Alternative Names: 3,8-Dihydroxy Urolithin; 2',7-Dihydroxy-3,4-benzocoumarin. CAS No. 1143-70-0. Pack Sizes: 10mg. Product ID: S5312. Formula: C13H8O4. Smiles: C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Vadimezan (DMXAA) | Vadimezan (DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3. Group: Inhibitors. Alternative Names: ASA404, NSC 640488. CAS No. 117570-53-3. Pack Sizes: 5mg. Product ID: S1537. Formula: C17H14O4. Smiles: CC1=C(C2=C(C=C1)C(=O)C3=CC=CC(=C3O2)CC(=O)O)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Valemetostat (DS-3201) | Valemetostat (DS-3201, DS-3201b) is a selective EZH1/2 dual inhibitor. Group: Inhibitors. Alternative Names: DS-3201b. CAS No. 1809336-39-7. Pack Sizes: 5mg. Product ID: S8926. Formula: C26H34ClN3O4. . Smiles: CC1=CC(=C(C(=O)N1)CNC(=O)C2=CC(=C3C(=C2C)OC(O3)(C)C4CCC(CC4)N(C)C)Cl)C. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Vanzacaftor (VX-121) | Vanzacaftor(VX-121) is an orally active corrector of Cystic fibrosis transmembrane conductance regulator (CFTR). Vanzacaftor improves the processing and trafficking of CFTR protein and increases chloride transport in combination with Tezacaftor and Deutivacaftor. Group: Inhibitors. Alternative Names: VX-121. CAS No. 2374124-49-7. Pack Sizes: 1mg. Product ID: E1701. Formula: C32H39N7O4S. | United States; Europe |
| VBIT-4 | VBIT-4 is a voltage-dependent anion channel (VDAC) oligomerization inhibitor that decreases mitochondrial DNA (mtDNA) release, type I interferon (IFN) signaling, neutrophil extracellular traps, and disease severity in a mouse model of systemic lupus erythematosus. Group: Inhibitors. CAS No. 2086257-77-2. Pack Sizes: 5mg. Product ID: S3544. Formula: C21H23ClF3N3O3. Smiles: OCC(CC(=O)NC1=CC=C(Cl)C=C1)N2CCN(CC2)C3=CC=C(OC(F)(F)F)C=C3. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| VCAM1 Antibody [M19B7] | VCAM1,VCAM-1. Group: Antibodies. Alternative Names: VCAM1. CAS No. Pack Sizes: 20ul. Product ID: F1145. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| VDAC1 / Porin + VDAC2 Antibody [F9G1] | Porin,VDAC,VDAC1,VDAC1 / Porin,VDAC1 / Porin + VDAC2. Group: Antibodies. Alternative Names: Porin,VDAC,VDAC1,VDAC1 / Porin + VDAC2. CAS No. Pack Sizes: 20uL. Product ID: F2882. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| VDAC Antibody [D6L19] | Porin,VDAC,VDAC1,VDAC1 / Porin, Plasmalemmal porin, Porin 31HL, Porin 31HM. Group: Antibodies. Alternative Names: Porin,VDAC,VDAC1,VDAC1 / Porin, Plasmalemmal porin, Porin 31HL, Porin 31HM. Pack Sizes: 20ul. Product ID: F0314. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| VE-821 | VE-821(ATR inhibitor IV) is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM in cell-free assays, shows inhibition of H2AX phosphorylation, minimal activity against PIKKs ATM, DNA-PK, mTOR and PI3Kγ. Group: Inhibitors. Alternative Names: ATR inhibitor IV. CAS No. 1232410-49-9. Pack Sizes: 10mg. Product ID: S8007. Formula: C18H16N4O3S. Smiles: CS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C(=O)NC3=CC=CC=C3)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| VEGFA Antibody [G24N11] | VEGFA Antibody [G24N11]. Group: Antibodies. Pack Sizes: 20uL. Product ID: F2527. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| VEGF Receptor 2 Antibody [J9N19] | CD309 (FLK1),Flk-1,VEGF Receptor 2,VEGFR-2. Group: Antibodies. Alternative Names: CD309,Flk-1,VEGF Receptor 2,VEGFR-2. Pack Sizes: 20uL. Product ID: F3049. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Veliparib (ABT-888) | Veliparib (ABT-888, NSC 737664) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Veliparib increases autophagy and apoptosis. Phase 3. Group: Inhibitors. Alternative Names: NSC 737664. CAS No. 912444-00-9. Pack Sizes: 1g. Product ID: S1004. Formula: C13H16N4O. Smiles: CC1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| VER-155008 | VER155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78 (HSPA5, Bip), respectively, >100-fold selectivity over HSP90. VER155008 inhibits autophagy and causes reduced levels of HSP90 client proteins. Group: Inhibitors. CAS No. 1134156-31-2. Pack Sizes: 10mg. Product ID: S7751. Formula: C25H23Cl2N7O4. Smiles: C1=CC(=CC=C1COCC2C(C(C(O2)N3C4=NC=NC(=C4N=C3NCC5=CC(=C(C=C5)Cl)Cl)N)O)O)C#N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Verapamil HCl | Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4. Group: Inhibitors. Alternative Names: CP-16533-1, (±)-Verapamil. CAS No. 152-11-4. Pack Sizes: 50mg. Product ID: S4202. Formula: C27H38N2O4.HCl. Smiles: CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Verteporfin | Verteporfin is a small molecule that inhibits TEAD-YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent derived from porphyrin. Verteporfin is an autophagy inhibitor. Verteporfin inhibits cell proliferation and induces apoptosis. Group: Inhibitors. Alternative Names: CL 318952. CAS No. 129497-78-5. Pack Sizes: 10mg. Product ID: S1786. Formula: C41H42N4O8. Smiles: COC(=O)CCC1=C(C)C2=CC3=NC(=CC4=C(C)C(=C([NH]4)C=C5N=C(C=C1[NH]2)C(=C5C)CCC(O)=O)C=C)C6=CC=C(C(C(=O)OC)C36C)C(=O)OC. Storage Conditions: 3 years-20°C powder. | United States; Europe |
| VGluT1 Antibody [E6H10] | Vesicular Glutamate Transporter 1,VGluT1. Group: Antibodies. Alternative Names: BNPI, VGLUT1, SLC17A7, Vesicular glutamate transporter 1, VGluT1, Brain-specific Na(+)-dependent inorganic phosphate cotransporter, Solute carrier family 17 member 7. CAS No. Pack Sizes: 20uL. Product ID: F3458. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Vimentin Antibody [B13H12] | Vimentin Antibody [B13H12]. Group: Antibodies. Pack Sizes: 20ul. Product ID: F0166. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Vimentin Antibody [N21E20] | Vimentin Antibody [N21E20]. Group: Antibodies. Pack Sizes: 20uL. Product ID: F2517. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Vincristine (Leurocristine) Sulfate | Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis. Group: Inhibitors. Alternative Names: Leurocristine sulfate, NSC-67574 sulfate, 22-Oxovincaleukoblastine sulfate. CAS No. 2068-78-2. Pack Sizes: 10mg. Product ID: S1241. Formula: C46H58N4O14S. Smiles: CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Vinculin Antibody [M20M17] | Vinculin Antibody [M20M17]. Group: Antibodies. Pack Sizes: 20ul. Product ID: F0110. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Vismodegib (GDC-0449) | Vismodegib (GDC-0449) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM in a cell-free assay. Group: Inhibitors. Alternative Names: GDC-0449. CAS No. 879085-55-9. Pack Sizes: 5mg. Product ID: S1082. Formula: C19H14Cl2N2O3S. Smiles: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Volasertib (BI6727) | Volasertib is a highly potent Plk1 inhibitor with IC50 of 0.87 nM in a cell-free assay. It shows 6- and 65-fold greater selectivity against Plk2 and Plk3. Volasertib induces cell cycle arrest and apoptosis in various cancer cells. Phase 3. Group: Inhibitors. Alternative Names: BI 6727. CAS No. 755038-65-4. Pack Sizes: 5mg. Product ID: S2235. Formula: C34H50N8O3. Smiles: CCC1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Vorasidenib (AG-881) | Vorasidenib (AG-881) is an orally available inhibitor of mutated forms of both isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2). Group: Inhibitors. CAS No. 1644545-52-7. Pack Sizes: 2mg. Product ID: S8611. Formula: C14H13ClF6N6. Smiles: CC(C(F)(F)F)NC1=NC(=NC(=N1)C2=NC(=CC=C2)Cl)NC(C)C(F)(F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Vorinostat (SAHA) | Vorinostat (SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification. Group: Inhibitors. Alternative Names: MK0683, Suberoylanilide hydroxamic acid. CAS No. 149647-78-9. Pack Sizes: 200mg. Product ID: S1047. Formula: C14H20N2O3. Smiles: C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| VPA (Valproic acid) | VPA (Valproic acid) is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. It is also a histone deacetylase (HDAC) inhibitor and is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α. Valproic acid activates Notch-1 signaling. Group: Inhibitors. Alternative Names: 2-Propylvaleric Acid, Valproate. CAS No. 99-66-1. Pack Sizes: 25mg. Product ID: S3944. Formula: C8H16O2. Smiles: CCCC(CCC)C(=O)O. Storage Conditions: 2 years -20°C liquid. | United States; Europe |
| VPS34-IN1 | Vps34-IN1 is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM invitro,which does not significantly inhibit the isoforms of class I as well as class II PI3Ks. Vps34-IN1 modulates autophagy. Group: Inhibitors. Alternative Names: Vps34-IN-1. CAS No. 1383716-33-3. Pack Sizes: 5mg. Product ID: S7980. Formula: C21H24ClN7O. Smiles: CC(C)(CNC1=NC=C(C(=N1)CC2CC2)C3=NC(=NC=C3)NC4=CC(=NC=C4)Cl)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| VT3989 | VT3989 (YAP/TAZ inhibitor-3) is a potent and selective oral inhibitor of TEAD auto-palmitoylation, blocking its interaction with yes-associated protein (YAP). It exhibits antitumor activity and shows potential for treating mesothelioma and solid tumors with NF2 mutations. Group: Inhibitors. Alternative Names: YAP/TAZ inhibitor-3. CAS No. 2506273-81-8. Pack Sizes: 1mg. Product ID: E6486. Formula: C21H18F3NO3. | United States; Europe |
| VTP50469 | VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity. Group: Inhibitors. CAS No. 2169916-18-9. Pack Sizes: 5mg. Product ID: S8934. Formula: C32H47FN6O4S. Smiles: CC(C)N(C(C)C)C(=O)C1=C(OC2=CN=CN=C2N3CC4(CCN(CC4)CC5CCC(CC5)N[S](C)(=O)=O)C3)C=CC(=C1)F. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| VX-445 (Elexacaftor) | Elexacaftor (VX-445) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector.This is a compound which is not chiral purity. Group: Inhibitors. CAS No. 2216712-66-0. Pack Sizes: 5mg. Product ID: S8851. Formula: C26H34F3N7O4S. Smiles: CC1CC(N(C1)C2=C(C=CC(=N2)N3C=CC(=N3)OCC(C)(C)C(F)(F)F)C(=O)NS(=O)(=O)C4=CN(N=C4C)C)(C)C. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| VX-809 (Lumacaftor) | Lumacaftor (VX-809, VRT 826809) acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation,EC50 of 0.1 μM in fisher rat thyroid cells. Phase 3. Group: Inhibitors. Alternative Names: VRT 826809. CAS No. 936727-05-8. Pack Sizes: 5mg. Product ID: S1565. Formula: C24H18F2N2O5. Smiles: CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| WH-4-023 | WH-4-023 (KIN001-112, KIN112, Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases. Group: Inhibitors. Alternative Names: KIN001-112, KIN112, Dual LCK/SRC inhibitor. CAS No. 837422-57-8. Pack Sizes: 5mg. Product ID: S7565. Formula: C32H36N6O4. Smiles: CC1=C(C(=CC=C1)C)OC(=O)N(C2=C(C=C(C=C2)OC)OC)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCN(CC5)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Wnt-C59 (C59) | Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM in HEK293 cells. Group: Inhibitors. CAS No. 1243243-89-1. Pack Sizes: 5mg. Product ID: S7037. Formula: C25H21N3O. Smiles: CC1=NC=CC(=C1)C2=CC=C(C=C2)CC(=O)NC3=CC=C(C=C3)C4=CN=CC=C4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Wortmannin (SL-2052) | Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM in a cell-free assay, with little selectivity within the PI3K family. Wortmannin blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM in cell-free assays. Wortmannin also inhibits PLK1 activity. Group: Inhibitors. Alternative Names: KY 12420, SL-2052, BRN 0067676, NSC 627609. CAS No. 19545-26-7. Pack Sizes: 5mg. Product ID: S2758. Formula: C23H24O8. Smiles: CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C5=COC(=C54)C3=O)COC)C)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| WY-14643 (Pirinixic Acid) | WY-14643 (Pirinixic Acid, NSC 310038) is a potent and selective PPARα activator with an EC50 of 1.5 μM. Group: Inhibitors. Alternative Names: NSC 310038. CAS No. 50892-23-4. Pack Sizes: 50mg. Product ID: S8029. Formula: C14H14ClN3O2S. Smiles: CC1=C(C(=CC=C1)NC2=CC(=NC(=N2)SCC(=O)O)Cl)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| XAV-939 | XAV-939 (NVP-XAV939) selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-κB or TGF-β. Group: Inhibitors. Alternative Names: NVP-XAV939. CAS No. 284028-89-3. Pack Sizes: 10mg. Product ID: S1180. Formula: C14H11F3N2OS. Smiles: C1CSCC2=C1N=C(NC2=O)C3=CC=C(C=C3)C(F)(F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| XBP-1s Antibody [N17H18] | XBP-1s Antibody [N17H18]. Group: Antibodies. Alternative Names: X-box-binding protein 1; XBP-1; Tax-responsive element-binding protein 5 (TREB-5); X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form; Xbp1; Treb5. Pack Sizes: 20uL. Product ID: F4186. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
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