Selleck Chemicals - Products
United States; Europe
Selleck Chemicals supplies bioactive small molecules, inhibitors, compound libraries, antibodies, natural products and related research reagents for life science research.
| Product | Description | |
|---|---|---|
| EPZ-6438 (Tazemetostat) | Tazemetostat (EPZ-6438, E7438) is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs. Group: Inhibitors. Alternative Names: E7438. CAS No. 1403254-99-8. Pack Sizes: 10mg. Product ID: S7128. Formula: C34H44N4O4. Smiles: CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCOCC5. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| ERAS-0015 | ERAS-0015(JYP0015) is a tricomplex inhibitor of panRAS(ON) targeting of active RAS, it binds to Cyclophilin A (CYPA) to form a high-affinity complex that sterically occludes RAS-effector interactions. It exhibits potential for research in RAS-mutant solid tumors. Group: Inhibitors. Alternative Names: JYP0015. CAS No. 3034673-92-9. Pack Sizes: 1mg. Product ID: E5848. Formula: C46H60N8O5S. | United States; Europe |
| Erastin | Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. Solutions are unstable and should be fresh-prepared. Group: Inhibitors. CAS No. 571203-78-6. Pack Sizes: 5mg. Product ID: S7242. Formula: C30H31ClN4O4. Smiles: CCOC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N4CCN(CC4)C(=O)COC5=CC=C(C=C5)Cl. | United States; Europe |
| Erdafitinib (JNJ-42756493) | Erdafitinib is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Erdafitinib also binds to RET (c-RET), CSF-1R, PDGFR-α / PDGFR-β, FLT4, Kit (c-Kit) and VEGFR-2 and induces cellular apoptosis. Group: Inhibitors. Alternative Names: JNJ-42756493. CAS No. 1346242-81-6. Pack Sizes: 5mg. Product ID: S8401. Formula: C25H30N6O2. Smiles: CC(C)NCCN(C1=CC2=NC(=CN=C2C=C1)C3=CN(N=C3)C)C4=CC(=CC(=C4)OC)OC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Erlotinib (CP-358774) | Erlotinib is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Erlotinib induces autophagy. Group: Inhibitors. Alternative Names: CP358774, NSC 718781,OSI-774. CAS No. 183321-74-6. Pack Sizes: 50mg. Product ID: S7786. Formula: C22H23N3O4. Smiles: COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Etomoxir | Etomoxir ((R)-(+)-Etomoxir) is an irreversible, small-molecule inhibitor of carnitine palmitoyl-transferase 1a (CPT1a). It inhibits fatty acid oxidation (FAO) and may have potential in treating diabetes, inflammation, cancer and cardiac metabolic diseases. Group: Inhibitors. Alternative Names: (R)-(+)-Etomoxir. CAS No. 124083-20-1. Pack Sizes: 5mg. Product ID: E4787. Formula: C17H23ClO4. | United States; Europe |
| Etomoxir sodium salt | Etomoxir sodium salt ((R)-(+)-Etomoxir sodium salt) is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane. Etomoxir enhances palmitate-induced cell apoptosis. Group: Inhibitors. Alternative Names: (R)-(+)-Etomoxir sodium salt. CAS No. 828934-41-4. Pack Sizes: 5mg. Product ID: S8244. Formula: C15H18ClO4.Na. Smiles: C1C(O1)(CCCCCCOC2=CC=C(C=C2)Cl)C(=O)[O-].[Na+]. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Etoposide | Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity which enhances double-strand and single-strand cleavage of DNA and reversibly inhibits repair by topoisomerase II binding. Etoposide induces autophagy, mitophagy and apoptosis. Group: Inhibitors. Alternative Names: VP-16213,VP-16. CAS No. 33419-42-0. Pack Sizes: 1g. Product ID: S1225. Formula: C29H32O13. Smiles: CC1OCC2C(O1)C(C(C(O2)OC3C4COC(=O)C4C(C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Ezh2 Antibody [M10N8] | Ezh2,KMT6 / EZH2. Group: Antibodies. Alternative Names: Ezh2,KMT6 / EZH2. Pack Sizes: 20ul. Product ID: F0281. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| FACL4 Antibody [B15L22] | ACSL4,FACL4. Group: Antibodies. Alternative Names: ACSL4,FACL4. Pack Sizes: 20ul. Product ID: F1153. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| FAK Antibody [J10N20] | FAK Antibody [J10N20]. Group: Antibodies. Pack Sizes: 20ul. Product ID: F0431. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Fasudil (HA-1077) Hydrochloride | Fasudil HCl, a potent and selective inhibitor of Rho kinase, displays less potent inhibiton over PKA, PKG, PKC and MLCK with Ki of 1.6, 1.6, 3.3, and 36 μM in cell-free assays, respectively. Fasudil is also a calcium channel blocker. Group: Inhibitors. Alternative Names: AT-877,HA-1077 HCl. CAS No. 105628-07-7. Pack Sizes: 1g. Product ID: S1573. Formula: C14H17N3O2S.HCl. Smiles: C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Fatty Acid Synthase Antibody [K9D22] | FASN,Fatty Acid Synthase,Fatty Acid Synthase / FASN. Group: Antibodies. Alternative Names: FASN,Fatty Acid Synthase. Pack Sizes: 20ul. Product ID: F0225. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| FAZ-3532 | FAZ-3532 is a potent inhibitor of G3BP that binds to G3BP1 with a Kd of 0.54?μM, inhibiting co-condensation of G3BP1, Caprin1, and RNA, and blocking stress granule formation in cells. It specifically targets the protein-protein interaction within the NTF2L domain of G3BP1 without affecting its dimerization or RNA-binding, making it a useful tool to study the immunological role of stress granules during viral infection. Group: Inhibitors. CAS No. 3036029-72-5. Pack Sizes: 1mg. Product ID: E5928. Formula: C38H56FN5O7. | United States; Europe |
| FCCP | FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone, Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone) is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes. Group: Inhibitors. Alternative Names: Trifluoromethoxy carbonylcyanide phenylhydrazone, Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone. CAS No. 370-86-5. Pack Sizes: 10mg. Product ID: S8276. Formula: C10H5F3N4O. Smiles: C1=CC(=CC=C1NN=C(C#N)C#N)OC(F)(F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| FDA-approved Drug Library | A unique collection of 3183 approved drugs and API included in pharmacopoeia for high throughput screening (HTS) and high content screening (HCS). Group: Compound libraries. CAS No. 1908-9-17. Pack Sizes: 100uL / well. Product ID: L1300. Formula: 2809 compounds pre-dissolved in 10mM DMSO, 271 compounds pre-dissolved in 10mM water, 82 compounds pre-dissolved in 2mM DMSO, 19 compounds pre-dissolved in 2mM water and 2 compounds pre-dissolved in 2mg/ml DMSO. Storage Conditions: 12 months-20°Cin DMSO. 24 months-80°Cin DMSO. | United States; Europe |
| Fedratinib (TG101348) | Fedratinib (SAR302503, TG101348) is a selective inhibitor of JAK2 with IC50 of 3 nM in cell-free assays, 35- and 334-fold more selective for JAK2 versus JAK1 and JAK3. Fedratinib also inhibits FMS-like tyrosine kinase 3 (FLT3) and RET (c-RET) with IC50 of 15 nM and 48 nM, respectively. Fedratinib has potential antineoplastic activity. Fedratinib inhibits proliferation and induces apoptosis. Phase 2. Group: Inhibitors. Alternative Names: SAR302503. CAS No. 936091-26-8. Pack Sizes: 5mg. Product ID: S2736. Formula: C27H36N6O3S. Smiles: CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Fenofibrate | Fenofibrate is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. Fenofibrate induces autophagy. Group: Inhibitors. Alternative Names: NSC-281319. CAS No. 49562-28-9. Pack Sizes: 50mg. Product ID: S1794. Formula: C20H21ClO4. Smiles: CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Ferritin Heavy Chain Antibody [N2N7] | Ferritin Heavy Chain Antibody [N2N7]. Group: Antibodies. Alternative Names: Fth, Fth1, Ferritin heavy chain, Ferritin H subunit. Pack Sizes: 20uL. Product ID: F3878. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Ferrostatin-1 (Fer-1) | Fer-1 (Ferrostatin-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. Group: Inhibitors. CAS No. 347174-05-4. Pack Sizes: 5mg. Product ID: S7243. Formula: C15H22N2O2. Smiles: CCOC(=O)C1=CC(=C(C=C1)NC2CCCCC2)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Fibronectin Antibody [C18P7] | Fibronectin Antibody [C18P7]. Group: Antibodies. Alternative Names: FN; FN1; Fibronectin; Cold-insoluble globulin; CIG. CAS No. Pack Sizes: 20uL. Product ID: F4795. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Fibronectin/FN1 Antibody [C12E22] | Fibronectin,Fibronectin, cell binding domain,Fibronectin, Cellular,Fibronectin/FN1. Group: Antibodies. Alternative Names: Fibronectin, Cold-insoluble globulin (CIG), FN1, FN. Pack Sizes: 20uL. Product ID: F0886. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Finerenone (BAY 94-8862) | Finerenone (FIN, BAY 94-8862) is a highly selective and orally available nonsteroidal antagonist of mineralocorticoid receptor (MR) with IC50 of 18 nM. Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease. Group: Inhibitors. Alternative Names: FIN, BAY 94-8862. CAS No. 1050477-31-0. Pack Sizes: 5mg. Product ID: S9702. Formula: C21H22N4O3. Smiles: CCOC1=NC=C(C)C2=C1C(C3=CC=C(C=C3OC)C#N)C(=C(C)N2)C(N)=O. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Fisetin | Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins. Group: Inhibitors. CAS No. 528-48-3. Pack Sizes: 1g. Product ID: S2298. Formula: C15H10O6. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| FK506 (Tacrolimus) | Tacrolimus (FK506) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus induces vascular endothelial autophagy. Group: Inhibitors. Alternative Names: FR900506, Fujimycin. CAS No. 104987-11-3. Pack Sizes: 1g. Product ID: S5003. Formula: C44H69NO12. Smiles: CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| FK866 (Daporinad) | Daporinad (FK866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with IC50 of 0.09 nM in a cell-free assay. Daporinad (FK866, APO866) triggers autophagy. Phase 1/2. Group: Inhibitors. Alternative Names: APO866. CAS No. 658084-64-1. Pack Sizes: 5mg. Product ID: S2799. Formula: C24H29N3O2. Smiles: C1CN(CCC1CCCCNC(=O)C=CC2=CN=CC=C2)C(=O)C3=CC=CC=C3. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Flavopiridol (Alvocidib, HMR-1275) | Flavopiridol (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4, CDK6, and CDK9 with IC50 values in the 20-100 nM range. It is more selective for CDK1, 2, 4, 6, 9 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol induces autophagy and ER stress. Flavopiridol blocks HIV-1 replication. Phase 1/2. Group: Inhibitors. Alternative Names: NSC 649890, HMR-1275, L86-8275. CAS No. 146426-40-6. Pack Sizes: 5mg. Product ID: S1230. Formula: C21H20ClNO5. Smiles: CN1CCC(C(C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Fludarabine | Fludarabine is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis. Group: Inhibitors. Alternative Names: FaraA, Fludarabinum, NSC 118218. CAS No. 21679-14-1. Pack Sizes: 10mg. Product ID: S1491. Formula: C10H12FN5O4. Smiles: C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)CO)O)O)F)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Fluorofurimazine (FFz) | Fluorofurimazine is a novel furimazine analogue, with increased aqueous solubility enabling higher signal emission than furimazine for bioluminescence imaging. Fluorofurimazine enables higher substrate loading and improved optical imaging sensitivity in in-vivo. Group: Inhibitors. CAS No. 2412089-96-2. Pack Sizes: 5mg. Product ID: E1620. Formula: C24H18F2N4O2. Storage Conditions: 3 years -20°C(in the dark) powder1 year -80°C(in the dark) in solvent. | United States; Europe |
| Forskolin (Colforsin) | Forskolin (Colforsin) is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology. Forskolin also activates PXR and FXR activity. Forskolin stimulates autophagy. Group: Inhibitors. Alternative Names: HL 362, Coleonol. CAS No. 66575-29-9. Pack Sizes: 10mg. Product ID: S2449. Formula: C22H34O7. Smiles: CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)C)O. Storage Conditions: 3 years -20°C(in the dark) powder1 year -80°C(in the dark) in solvent. | United States; Europe |
| FoxO1 Antibody [J3J15] | FKHR/FOXO1,FoxO1,FOXO1A. Group: Antibodies. Alternative Names: FKHR/FOXO1,FoxO1,FOXO1A. Pack Sizes: 20ul. Product ID: F0141. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| FTY720 (Fingolimod) Hydrochloride | Fingolimod (FTY720, Fingolimod Hydrochloride) HCl is a S1P antagonist with IC50 of 0.033 nM in K562, and NK cells. Please use saline solution rather than PBS for dilutions. PBS may cause precipitation. Group: Inhibitors. Alternative Names: Fingolimod Hydrochloride,FTY720. CAS No. 162359-56-0. Pack Sizes: 100mg. Product ID: S5002. Formula: C19H33NO2.HCl. Smiles: CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Fulvestrant (ICI-182780) | Fulvestrant is an estrogen receptor (ER) antagonist with IC50 of 0.94 nM in a cell-free assay. Fulvestrant also induces autophagy and apoptosis and has antitumor activity. Group: Inhibitors. Alternative Names: ICI-182780, ZD 9238, ZM 182780. CAS No. 129453-61-8. Pack Sizes: 25mg. Product ID: S1191. Formula: C32H47F5O3S. Smiles: CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Furimazine (PBI 3939) | Furimazine (PBI 3939) is a synthetic imidazopyrazinone compound that serves as a substrate for the NanoLuc luciferase (Nluc) enzyme. When combined with Nluc, Furimazine produces exceptionally bright bioluminescent signals in mammalian cells, significantly enhancing the sensitivity of bioluminescence imaging (BLI) applications. Group: Inhibitors. Alternative Names: PBI 3939. CAS No. 1374040-24-0. Pack Sizes: 5mg. Product ID: E5806. Formula: C24H19N3O2. | United States; Europe |
| G3BP1 Antibody [P16B11] | G3BP,G3BP1. Group: Antibodies. Alternative Names: G3BP, G3BP1. CAS No. Pack Sizes: 20uL. Product ID: F1559. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| G418 Sulfate (Geneticin) | Geneticin (G418 Sulfate), an aminoglycoside antibiotic, is an elongation inhibitor of 80 S ribosomes that blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells.It is commonly used as a screening reagent for eukaryotic cells to screen transfected or transformed cells. Group: Inhibitors. CAS No. 108321-42-2. Pack Sizes: 1g. Product ID: S3028. Formula: C20H40N4O10.2H2SO4. Smiles: CC(C1C(C(C(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| GAD67/GAD1 Antibody [H1N10] | GAD1,GAD67,GAD-67. Group: Antibodies. Alternative Names: GAD1,GAD67. Pack Sizes: 20uL. Product ID: F2532. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Galectin-3/LGALS3 Antibody [N13N19] | Galectin 3,galectin-3,Galectin-3/LGALS3. Group: Antibodies. Alternative Names: galectin-3,LGALS3. Pack Sizes: 20uL. Product ID: F1417. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Galunisertib (LY2157299) | Galunisertib (LY2157299) is a potent TGFβ receptor I (TβRI / ALK5) inhibitor with IC50 of 56 nM in a cell-free assay. Phase 2/3. Group: Inhibitors. CAS No. 700874-72-2. Pack Sizes: 5mg. Product ID: S2230. Formula: C22H19N5O. Smiles: CC1=NC(=CC=C1)C2=NN3CCCC3=C2C4=C5C=C(C=CC5=NC=C4)C(=O)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Ganciclovir (BW 759) | Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay. Group: Inhibitors. Alternative Names: RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine. CAS No. 82410-32-0. Pack Sizes: 50mg. Product ID: S1878. Formula: C9H13N5O4. Smiles: C1=NC2=C(N1COC(CO)CO)N=C(NC2=O)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| GANT 61 (NSC 136476) | GANT61 (NSC 136476) is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM in GLI1 expressing HEK293T cell, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation. GANT61 induces apoptosis and activates protective autophagy in LX-2 cells. Group: Inhibitors. Alternative Names: NSC 136476. CAS No. 500579-04-4. Pack Sizes: 10mg. Product ID: S8075. Formula: C27H35N5. Smiles: CN(C)C1=CC=CC=C1CN2CCCN(C2C3=CC=NC=C3)CC4=CC=CC=C4N(C)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| GAPDH Antibody [A19L10] | GAPDH,GAPDH Loading Control,Glyceraldehyde-3-Phosphate Dehydrogenase. Group: Antibodies. Alternative Names: GAPDH,GAPDH Loading Control,Glyceraldehyde-3-Phosphate Dehydrogenase. Pack Sizes: 20ul. Product ID: F0003. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| GAPDH Antibody [G15H12] | GAPDH,GAPDH Loading Control,Glyceraldehyde-3-Phosphate Dehydrogenase. Group: Antibodies. Alternative Names: GAPDH,GAPDH Loading Control,Glyceraldehyde-3-Phosphate Dehydrogenase. Pack Sizes: 20uL. Product ID: F2511. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| GDC-0077 (Inavolisib) | Inavolisib (GDC-0077, RG6114, RO-7113755) is a potent selective inhibitor of PI3K alpha (PI3Kα) with an IC50 of 0.038 nM. GDC-0077 is >300-fold more selective for PI3K alpha over the other class I PI3K isoforms (beta, delta, and gamma) and >2000-fold more selective over PIK family members. GDC-0077 binds to the ATP binding site of PI3K and inhibits the phosphorylation of PIP2 to PIP3. Group: Inhibitors. Alternative Names: RG6114, RO-7113755. CAS No. 2060571-02-8. Pack Sizes: 5mg. Product ID: S8668. Formula: C18H19F2N5O4. Smiles: CC(C(=O)N)NC1=CC2=C(C=C1)C3=NC(=CN3CCO2)N4C(COC4=O)C(F)F. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| GDC-0879 | GDC-0879 (AR-00341677) is a novel, potent, and selective B-Raf inhibitor with IC50 of 0.13 nM in A375 and Colo205 cells with activity against c-Raf as well; no inhibition known to other protein kinases. Group: Inhibitors. Alternative Names: AR-00341677. CAS No. 905281-76-7. Pack Sizes: 2mg. Product ID: S1104. Formula: C19H18N4O2. Smiles: C1CC(=NO)C2=C1C=C(C=C2)C3=CN(N=C3C4=CC=NC=C4)CCO. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Gedatolisib (PKI-587) | Gedatolisib (PF-05212384, PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ and mTOR with IC50 of 0.4 nM, 5.4 nM and 1.6 nM in cell-free assays, respectively. Phase 2. Group: Inhibitors. Alternative Names: PF-05212384. CAS No. 1197160-78-3. Pack Sizes: 5mg. Product ID: S2628. Formula: C32H41N9O4. Smiles: CN(C)C1CCN(CC1)C(=O)C2=CC=C(C=C2)NC(=O)NC3=CC=C(C=C3)C4=NC(=NC(=N4)N5CCOCC5)N6CCOCC6. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Gefitinib (ZD1839) | Gefitinib is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively. Gefitinib promotes autophagy and apoptosis of lung cancer cells via blockade of the PI3K/AKT / mTOR pathway. Group: Inhibitors. Alternative Names: ZD1839. CAS No. 184475-35-2. Pack Sizes: 100mg. Product ID: S1025. Formula: C22H24ClFN4O3. Smiles: COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Gemcitabine | Gemcitabine, a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis. Group: Inhibitors. Alternative Names: LY-188011, NSC 613327. CAS No. 95058-81-4. Pack Sizes: 50mg. Product ID: S1714. Formula: C9H11F2N3O4. Smiles: C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F. Storage Conditions: powder, 4°C,3 years (in the dark) ; in solvent, -80°C,1 year (in the dark). | United States; Europe |
| Gemcitabine Hydrochloride | Gemcitabine is a pyrimidine nucleoside analog antitumor drug that can inhibit DNA synthesis and repair, leading to cell autophagy and apoptosis. It is mainly used to treat various solid tumors such as pancreatic cancer and non-small cell lung cancer, and is often combined with chemotherapy to enhance efficacy. Group: Inhibitors. Alternative Names: NSC 613327 HCl,LY-188011 HCl. CAS No. 122111-03-9. Pack Sizes: 25mg. Product ID: S1149. Formula: C9H11F2N3O4.HCI. Smiles: C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Genistein | Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM. Group: Inhibitors. Alternative Names: NPI 031L. CAS No. 446-72-0. Pack Sizes: 25mg. Product ID: S1342. Formula: C15H10O5. Smiles: C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| GFP Antibody [C20D20] | GFP,GFP, N-terminal,Green Fluorescent Protein,Green Fluorescent Protein (GFP),Green Fluorescent Protein (GFP), N terminal. Group: Antibodies. Alternative Names: GFP, GFP Tag, N-terminal,Green Fluorescent Protein. Pack Sizes: 20ul. Product ID: F0055. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| GFP Antibody [P14J20] | GFP,GFP, N-terminal,Green Fluorescent Protein,Green Fluorescent Protein (GFP),Green Fluorescent Protein (GFP), N terminal. Group: Antibodies. Alternative Names: GFP, N-terminal,Green Fluorescent Protein. Pack Sizes: 20uL. Product ID: F2890. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| GI254023X (GI4023) | GI254023X (GI 4023, SRI028594) is a selective inhibitor of ADAM10 with 100-fold selectivity for ADAM10 over ADAM17. The IC50 values for recombinant ADAM10 amd ADAM17 are 5.3 nM and 541 nM, respectively.GI254023X can inhibit MMP9. Group: Inhibitors. Alternative Names: GI 4023, SRI028594. CAS No. 260264-93-5. Pack Sizes: 2mg. Product ID: S8660. Formula: C21H33N3O4. Smiles: CC(C(CCCC1=CC=CC=C1)C(=O)NC(C(=O)NC)C(C)(C)C)N(C=O)O. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Glucocorticoid Receptor Antibody [D9N22] | Glucocorticoid Receptor,Glucocorticoid Receptor alpha,Glucocorticoid Receptor beta,GR/NR3C1 / Glucocorticoid Receptor. Group: Antibodies. Alternative Names: Glucocorticoid Receptor α/β, GR, NR3C1. Pack Sizes: 20uL. Product ID: F0479. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| GLUT1 Antibody [P22E15] | Glucose Transporter GLUT1,Glut1,GLUT-1. Group: Antibodies. Alternative Names: Glucose Transporter GLUT1,Glut1. CAS No. 40-60 kDa, 50-300 kDa. Pack Sizes: 20uL. Product ID: F1192. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Glutathione Peroxidase 4 Antibody [J16C12] | Glutathione Peroxidase 4,Glutathione Peroxidase 4/GPX4,GPX4. Group: Antibodies. Alternative Names: Glutathione Peroxidase 4,GPX4. Pack Sizes: 20uL. Product ID: F1580. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Glycyrrhizin (Glycyrrhizic Acid, NSC 167409) | Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO). Group: Inhibitors. CAS No. 1405-86-3. Pack Sizes: 10mg. Product ID: S2302. Formula: C42H62O16. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| GM130 Antibody [N8D2] | GM130 Antibody [N8D2]. Group: Antibodies. Pack Sizes: 20ul. Product ID: F0080. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| GO-203 TFA | GO-203 is a D-amino acid cell-penetrating peptide inhibitor of MUC1-C dimerization and thereby its oncogenic function. Group: Inhibitors. CAS No. 1222186-26-6. Pack Sizes: 2mg. Product ID: S8674. Formula: C87H170N52O19S2.C2HF3O2. Smiles: C(CCN)CC(C(=O)NC(CC(=O)N)C(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CS)NC(=O)C(CCC(=O)N)NC(=O)C(CS)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)N.C(=O)(C(F)(F)F)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Go 6983 | Go 6983 (GOE 6983, Gö 6983) is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ and PKCδ with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively; less potent to PKCζ and inactive to PKCμ. Group: Inhibitors. Alternative Names: GOE 6983, Gö 6983. CAS No. 133053-19-7. Pack Sizes: 10mg. Product ID: S2911. Formula: C26H26N4O3. Smiles: CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Grp75 Antibody [N3C14] | GRP 75,Grp75,Grp75/MOT. Group: Antibodies. Alternative Names: GRP 75,MOT, HSPA9. Pack Sizes: 20ul. Product ID: F0782. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| GRP78/BIP Antibody [J10G21] | BiP,BiP/GRP78,GRP78 BiP,GRP78/HSPA5,HSPA5,HSPA5/BiP/GRP78. Group: Antibodies. Alternative Names: BiP,BiP/GRP78,GRP78/HSPA5,HSPA5. Pack Sizes: 20ul. Product ID: F0221. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| GRP78/BIP Antibody [N15D19] | BiP,BiP/GRP78,GRP78 BiP,GRP78/HSPA5,HSPA5,HSPA5/BiP/GRP78. Group: Antibodies. Alternative Names: BiP,BiP/GRP78,GRP78/HSPA5,HSPA5. Pack Sizes: 20uL. Product ID: F2702. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| GSDMD Antibody [B5P20] | Gasdermin D,GSDMD,GSDMDC1. Group: Antibodies. Alternative Names: DF 5L; DF5L; DFNA 5L; DFNA5L; FKSG 10; FKSG10; FLJ12150; GSDMDC1; GSDMD. Pack Sizes: 20uL. Product ID: F1568. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| GSH (L-Glutathione reduced) | GSH (Glutathione) acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue. Group: Inhibitors. Alternative Names: Isethion, Glutathion, Tathion, L-Glutathione reduced, γ-L-Glutamyl-L-cysteinyl-glycine. CAS No. 70-18-8. Pack Sizes: 100mg. Product ID: S4606. Formula: C10H17N3O6S. Smiles: C(CC(=O)NC(CS)C(=O)NCC(=O)O)C(C(=O)O)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| GSK126 | GSK126 (GSK2816126A, GSK2816126) is a potent, highly selective EZH2 methyltransferase inhibitor with IC50 of 9.9 nM, >1000-fold selective for EZH2 over 20 other human methyltransferases. Group: Inhibitors. Alternative Names: GSK2816126A, GSK2816126. CAS No. 1346574-57-9. Pack Sizes: 5mg. Product ID: S7061. Formula: C31H38N6O2. Smiles: CCC(C)N1C=C(C2=C(C=C(C=C21)C3=CN=C(C=C3)N4CCNCC4)C(=O)NCC5=C(C=C(NC5=O)C)C)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| GSK2606414 | GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. GSK2606414 impairs GANT-61 induced autophagy in NB cells with MYCN amplification. GSK2606414 exacerbates ER stress-induced apoptosis in HCT116 cells while reduces the apoptosis in SIL1 KD HeLa cells. Group: Inhibitors. CAS No. 1337531-36-8. Pack Sizes: 5mg. Product ID: S7307. Formula: C24H20F3N5O. Smiles: CN1C=C(C2=C(N=CN=C21)N)C3=CC4=C(C=C3)N(CC4)C(=O)CC5=CC(=CC=C5)C(F)(F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| GSK2879552 Dihydrochloride | GSK2879552 2HCl is a potent, selective, orally bioavailable, irreversible LSD1 inhibitor with Kiapp of 1.7 μM. Phase 1. Group: Inhibitors. CAS No. 1902123-72-1. Pack Sizes: 5mg. Product ID: S7796. Formula: C23H28N2O2.2HCl. Smiles: C1CN(CCC1CNC2CC2C3=CC=CC=C3)CC4=CC=C(C=C4)C(=O)O.Cl.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| GSK3326595 (Pemrametostat, EPZ015938) | Pemrametostat (GSK3326595, EPZ015938) is an orally active, potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) and potently inhibits tumor growth in vitro and in vivo in animal models. Group: Inhibitors. Alternative Names: EPZ015938. CAS No. 1616392-22-3. Pack Sizes: 5mg. Product ID: S8664. Formula: C24H32N6O3. Smiles: CC(=O)N1CCC(CC1)NC2=NC=NC(=C2)C(=O)NCC(CN3CCC4=CC=CC=C4C3)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| GSK-3β Antibody [B6C8] | GSK3 beta,GSK3 beta (phospho S9),GSK-3β. Group: Antibodies. Pack Sizes: 20ul. Product ID: F0142. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
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