Selleck Chemicals - Products
United States; Europe
Selleck Chemicals supplies bioactive small molecules, inhibitors, compound libraries, antibodies, natural products and related research reagents for life science research.
| Product | Description | |
|---|---|---|
| Gsk484 Hydrochloride | GSK484 HCl, a benzoimidazole derivative, is a selective and reversible inhibitor of peptidylarginine deiminase 4 (PAD4) with IC50 of 50 nM in the absence of Calcium. Group: Inhibitors. Alternative Names: GSK484 hydrochloride. CAS No. 1652591-81-5. Pack Sizes: 5mg. Product ID: S7803. Formula: C27H32ClN5O3. Smiles: CN1C2=C(C=C(C=C2OC)C(=O)N3CCC(C(C3)N)O)N=C1C4=CC5=CC=CC=C5N4CC6CC6.Cl. Storage Conditions: 3 years -20°C powder. |  United States; Europe |
| GSK8612 | GSK8612 is a highly potent and selective inhibitor for TBK1 (Tank-binding Kinase-1) with pKd of 8.0. Within 10-fold affinity with respect to TBK1, no off-targets of GSK8612 could be identified. Group: Inhibitors. CAS No. 2361659-62-1. Pack Sizes: 2mg. Product ID: S8872. Formula: C17H17BrF3N7O2S. Smiles: CC1=NN(C=C1NC2=NC=C(C(=N2)NCC3=CC=C(C=C3)S(=O)(=O)N)Br)CC(F)(F)F. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| GSK872 | GSK'872 is a potent and selective RIP3 kinase inhibitor which binds RIP3 kinase domain with high affinity (IC50=1.8 nM) and inhibits kinase activity with IC50 of 1.3 nM. It has minimal cross-reactivity. Group: Inhibitors. Alternative Names: GSK2399872A. CAS No. 1346546-69-7. Pack Sizes: 5mg. Product ID: S8465. Formula: C19H17N3O2S2. Smiles: CC(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=CC4=C(C=C3)SC=N4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| GSK-J4 Hydrochloride | GSK J4 HCl is a cell permeable prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM in a cell-free assay and inactive against a panel of demethylases of the JMJ family. Group: Inhibitors. CAS No. 1797983-09-5. Pack Sizes: 10mg. Product ID: S7070. Formula: C24H27N5O2.HCl. Smiles: CCOC(=O)CCNC1=CC(=NC(=N1)C2=CC=CC=N2)N3CCC4=CC=CC=C4CC3.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| GsMTx4 | GsMTx4 (Grammostola spatulata mechanotoxin 4, M-theraphotoxin-Gr1a, M-TRTX-Gr1a) is a spider venom peptide that inhibits cationic mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. Group: Peptides. CAS No. 1209500-46-8. Pack Sizes: 1mg. Product ID: P1205. Formula: C185H273N49O45S6. Storage Conditions: 3 years-20°C powder. | United States; Europe |
| GW3965 Hydrochloride | GW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM in cell-free assays, respectively. Group: Inhibitors. CAS No. 405911-17-3. Pack Sizes: 5mg. Product ID: S2630. Formula: C33H31ClF3NO3.HCl. Smiles: C1=CC=C(C=C1)C(CN(CCCOC2=CC=CC(=C2)CC(=O)O)CC3=C(C(=CC=C3)C(F)(F)F)Cl)C4=CC=CC=C4.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| GW4869 | GW4869 (GW69A, GW554869A) is a neutral, noncompetitive inhibitor of sphingomyelinase (SMase) with an IC50 of 1 μM. It is selective for N-SMase, and does not inhibit acid SMase at up to at least 150 μM, also is a commonly used exosome inhibitor. Group: Inhibitors. Alternative Names: GW69A, GW554869A. CAS No. 6823-69-4. Pack Sizes: 5mg. Product ID: S7609. Formula: C30H28N6O2.2HCl.XH2O. Smiles: C1CN=C(N1)C2=CC=C(C=C2)NC(=O)C=CC3=CC=C(C=C3)C=CC(=O)NC4=CC=C(C=C4)C5=NCCN5.Cl.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| GW6471 | GW 6471 is a potent antagonist of PPARα with IC50 of 0.24 μM. Group: Inhibitors. CAS No. 880635-03-0. Pack Sizes: 10mg. Product ID: S2798. Formula: C35H36F3N3O4. Smiles: CCC(=O)NCC(CC1=CC=C(C=C1)OCCC2=C(OC(=N2)C3=CC=CC=C3)C)NC(=CC(=O)C4=CC=C(C=C4)C(F)(F)F)C. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| GW9662 | GW9662 is a selective PPAR antagonist for PPARγ with IC50 of 3.3 nM in a cell-free assay, with at least 10- to 600-fold functional selectivity in cells with PPARγ versus PPARα and PPARδ. Group: Inhibitors. CAS No. 22978-25-2. Pack Sizes: 10mg. Product ID: S2915. Formula: C13H9ClN2O3. Smiles: C1=CC=C(C=C1)NC(=O)C2=C(C=CC(=C2)[N+](=O)[O-])Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| H-151 | H-151 is a highly potent and covalent inhibitor of STING that has noteworthy inhibitory activity both in human cells and in vivo. Group: Inhibitors. CAS No. 941987-60-6. Pack Sizes: 5mg. Product ID: S6652. Formula: C17H17N3O. Smiles: CCC1=CC=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| H2DCFDA (DCFH-DA) | H2DCFDA (DCFH-DA) is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS) production. It is de-esterified intracellularly and turns to highly fluorescent 2,7-dichlorofluorescein upon oxidation. It is used in sensitive and rapid quantitation of oxygen-reactive species in response to oxidative metabolism; microplate assay for detecting oxidative products in phagocytic cells, and quantitative multiwell myeloid differentiation assay.(Ex/Em=488/525 nm). Group: Inhibitors. Alternative Names: 2',7'-Dichlorodihydrofluorescein diacetate. CAS No. 4091-99-0. Pack Sizes: 25mg. Product ID: S9687. Formula: C24H16Cl2O7. Smiles: CC(=O)OC1=CC2=C(C=C1Cl)C(C3=C(O2)C=C(OC(C)=O)C(=C3)Cl)C4=C(C=CC=C4)C(O)=O. Storage Conditions: 3 years -20°C(in the dark) powder. | United States; Europe |
| H-89 Dihydrochloride | H 89 2HCl is a potent PKA inhibitor with Ki of 48 nM in a cell-free assay, 10-fold selective for PKA than PKG,500-fold greater selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II. H 89 2HCl induces autophagy. Group: Inhibitors. CAS No. 130964-39-5. Pack Sizes: 1g. Product ID: S1582. Formula: C20H20BrN3O2S.2HCl. Smiles: C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCNCC=CC3=CC=C(C=C3)Br.Cl.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Halofuginone | Halofuginone (RU-19110) is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal. Group: Inhibitors. Alternative Names: RU-19110. CAS No. 55837-20-2. Pack Sizes: 5mg. Product ID: S8144. Formula: C16H17BrClN3O3. Smiles: C1CC(C(NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Harringtonine | Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities. Group: Inhibitors. CAS No. 26833-85-2. Pack Sizes: 1mg. Product ID: S9063. Formula: C28H37NO9. | United States; Europe |
| HA-Tag Antibody [G15H8] | HA-Tag Antibody [G15H8]. Group: Antibodies. Alternative Names: Hemagglutinin Tag. Pack Sizes: 20uL. Product ID: F5084. | United States; Europe |
| HCQ (Hydroxychloroquine) Sulfate | Hydroxychloroquine (HCQ) Sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9. Group: Inhibitors. Alternative Names: NSC 4375. CAS No. 747-36-4. Pack Sizes: 10mg. Product ID: S4430. Formula: C18H28ClN3O5S. Smiles: CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO.OS(=O)(=O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| HDAC1 Antibody [P23M13] | HDAC1,Histone Deacetylase 1 (HDAC1). Group: Antibodies. Alternative Names: HDAC1,Histone Deacetylase 1. Pack Sizes: 20ul. Product ID: F0735. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Heme Oxygenase 1 Antibody [G7A14] | Heme Oxygenase 1,Heme Oxygenase 1/HMOX1,HMOX1,HO-1. Group: Antibodies. Alternative Names: HO, HO1, HMOX1, Heme oxygenase 1, HO-1. Pack Sizes: 20uL. Product ID: F3640. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Heparin Sodium | Heparin sodium, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has numerous important biological activities associated with its interaction with diverse proteins. Heparin is used as an anticoagulant primarily through its interaction with AT III by enhancing AT-IIImediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin prevents the induction of autophagy. Group: Inhibitors. CAS No. 9041-8-1. Pack Sizes: 200mg. Product ID: S1346. Formula: (C12H16NS2Na3)20. Smiles: CCC1CC(N[R])C(OC1CO[S]([O-])(=O)=O)OC2C(O)C(O)C(OC3C(CO[R])OC(OC4C(O)C(O[S]([O-])(=O)=O)C(OC5C(O)C(N[S]([O-])(=O)=O)C(C)OC5CO[S]([O-])(=O)=O)OC4C([O-])=O)C(N[S]([O-])(=O)=O)C3[S]([O-])(=O)=O)OC2C([O-]. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Hexokinase II Antibody [F23A5] | Hexokinase II,HK2,HXK II. Group: Antibodies. Alternative Names: Hexokinase-2, Hexokinase type II, Hexokinase-B, Muscle form hexokinase, HK II, HK2. CAS No. Pack Sizes: 20uL. Product ID: F2862. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| HIF-1α Antibody [E5D19] | HIF-1 alpha,HIF1A,HIF-1alpha,HIF-1α,Human HIF-1α,Hypoxia Inducible Factor 1 alpha. Group: Antibodies. Alternative Names: HIF1A,Hypoxia Inducible Factor 1 α. CAS No. Pack Sizes: 20uL. Product ID: F0101. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Histone H2A.X Antibody [H24L24] | Histone H2A.X,Histone H2AX. Group: Antibodies. Alternative Names: Histone H2A.X. Pack Sizes: 20ul. Product ID: F0284. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Histone H3 Antibody [G22B21] | Histone H3 Antibody [G22B21]. Group: Antibodies. Pack Sizes: 20ul. Product ID: F0057. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Histone H3 (tri methyl Lys27) Antibody [J13C2] | Histone H3 (tri methyl K27),trimethyl-Histone H3 (Lys27),Tri-Methyl-Histone H3 (Lys27),Trimethyl-Histone H3 (Lys27) - ChIP Validated. Group: Antibodies. Alternative Names: Histone H3 (tri methyl K27),trimethyl-Histone H3 (Lys27), H3K27me3. Pack Sizes: 20ul. Product ID: F0165. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Histone H3 (tri methyl Lys4) Antibody [A20A3] | ChIPAb+ Trimethyl-Histone H3 (Lys4) - ChIP Validated,Histone H3 (tri methyl K4),Trimethyl Histone H3 (Lys4),Trimethyl-Histone H3 (Lys4),Tri-Methyl-Histone H3 (Lys4). Group: Antibodies. Alternative Names: Histone H3 (tri methyl K4),Tri-Methyl-Histone H3 (Lys4), h3k4me3. Pack Sizes: 20ul. Product ID: F0365. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Histone H3 (tri methyl Lys9) Antibody [A8A1] | Histone H3 (tri methyl K9),Histone H3 [Trimethyl Lys9],trimethyl-Histone H3 (Lys9),Tri-Methyl-Histone H3 (Lys9). Group: Antibodies. Alternative Names: Histone H3 (tri methyl K9),Histone H3 [Trimethyl Lys9],Tri-Methyl-Histone H3 (Lys9), H3K9me3. Pack Sizes: 20uL. Product ID: F3394. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| HMGB1 Antibody [N2J9] | HMGB1 Antibody [N2J9]. Group: Antibodies. Alternative Names: High mobility group protein B1; High mobility group protein 1; HMG-1; HMGB1; HMG1. Pack Sizes: 20uL. Product ID: F4213. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| HRO761 | HRO761 is a potent, selective, allosteric inhibitor of Werner syndrome RecQ helicase (WRN). It binds at the interface of the D1 and D2 helicase domains, locking WRN in an inactive conformation, and demonstrates anti-proliferative effects specifically in microsatellite instability (MSI) cancer cells. Group: Inhibitors. CAS No. 2869954-34-5. Pack Sizes: 5mg. Product ID: E1908. Formula: C31H31ClF3N9O5. | United States; Europe |
| HSP60 Antibody [G1B22] | Heat Shock Protein 60,HSP 60,HSP60. Group: Antibodies. Alternative Names: Heat Shock Protein 60,HSP60. Pack Sizes: 20uL. Product ID: F0482. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Hsp70 Antibody [C13L16] | Heat Shock Protein 70,HSP 70,Hsp70. Group: Antibodies. Alternative Names: Heat Shock Protein 70,Hsp70. Pack Sizes: 20uL. Product ID: F1607. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| HSP90 Antibody [L2G2] | Heat Shock Protein 90,HSP90,HSP90 alpha / beta. Group: Antibodies. Alternative Names: Heat Shock Protein 90,HSP90,HSP90 alpha / beta. Pack Sizes: 20uL. Product ID: F0283. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Human IgG1 isotype control | Human IgG1 isotype control is suitable for use as a non-targeting isotype control in various in vitro and in vivo studies, is the isotype control of human IgG1κ antibody. Group: Antibodies. Pack Sizes: 1mg. Product ID: A2051. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| Human IgG4 isotype control | Human IgG4 isotype control is suitable for use as a non-targeting isotype control in various in vitro and in vivo studies, is the isotype control of human IgG4κ antibody. Group: Antibodies. Pack Sizes: 1mg. Product ID: A2052. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| Hydrocortisone (Cortisol) | Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland. Group: Inhibitors. Alternative Names: NSC 10483. CAS No. 50-23-7. Pack Sizes: 200mg. Product ID: S1696. Formula: C21H30O5. Smiles: CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Hydroxyurea | Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea activates apoptosis and autophagy. Hydroxyurea is used to treat HIV infection. Group: Inhibitors. Alternative Names: NCI-C04831, Hydroxycarbamide,NSC-32065. CAS No. 127-07-1. Pack Sizes: 200mg. Product ID: S1896. Formula: CH4N2O2. Smiles: C(=O)(N)NO. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Hygromycin B | Hygromycin B (Hygrovetine), a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome. Group: Inhibitors. Alternative Names: Hygrovetine. CAS No. 31282-04-9. Pack Sizes: 250mg. Product ID: S2908. Formula: C20H37N3O13. Smiles: CNC1CC(C(C(C1O)OC2C3C(C(C(O2)CO)O)OC4(O3)C(C(C(C(O4)C(CO)N)O)O)O)O)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| IACS-010759 (IACS-10759) | IACS-010759 (IACS-10759) is a potent and selective oxidative phosphorylation inhibitor (IC50 < 10 nM) that blocks cellular respiration through inhibition of complex I. Group: Inhibitors. CAS No. 1570496-34-2. Pack Sizes: 5mg. Product ID: S8731. Formula: C25H25F3N6O4S. Smiles: CC1=NC(=NN1CC2=CC(=CC=C2)N3CCC(CC3)S(=O)(=O)C)C4=NC(=NO4)C5=CC=C(C=C5)OC(F)(F)F. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Iadademstat (ORY-1001) Dihydrochloride | ORY-1001 (RG-6016) 2HCl is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor with IC50 of <20 nM, with high selectivity against related FAD dependent aminoxidases. Phase 1. Group: Inhibitors. Alternative Names: RG-6016. CAS No. 1431326-61-2. Pack Sizes: 5mg. Product ID: S7795. Formula: C15H22N2 . 2HCl. Smiles: C1CC(CCC1N)NC2CC2C3=CC=CC=C3.Cl.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| IAG933 | IAG933 (YAP-TEAD-IN-3) is a small molecule and acts as a YAP/TAZ-TEAD inhibitor. It also inhibits NCI-H2052 and can be used in research of tumor invasion and metastatic spread of solid tumors. Group: Inhibitors. Alternative Names: YAP-TEAD-IN-3. CAS No. 2714434-21-4. Pack Sizes: 1mg. Product ID: E1490. Formula: C27H26ClF2N3O4. | United States; Europe |
| Iberdomide (CC-220) | Iberdomide (CC-220) is a novel oral immunomodulatory compound that targets cereblon, part of the CRL4CRBN E3 ubiquitin ligase complex, with an IC50 of 60 nM in a competitive TR-FRET assay. Iberdomide (CC-220) induces apoptosis with antitumor and immunostimulatory activities. Group: Inhibitors. CAS No. 1323403-33-3. Pack Sizes: 2mg. Product ID: S8760. Formula: C25H27N3O5. Smiles: C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3OCC4=CC=C(C=C4)CN5CCOCC5. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| IBMX (3-Isobutyl-1-methylxanthine) | IBMX (Isobutylmethylxanthine, 1-Methyl-3-Isobutylxanthine) is a nonspecific inhibitor of phosphodiesterase (PDE) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. It may enhance the intracellular cAMP levels and also acts as an adenosine (A1) receptor antagonist. Group: Inhibitors. Alternative Names: Isobutylmethylxanthine, 1-Methyl-3-Isobutylxanthine. CAS No. 28822-58-4. Pack Sizes: 5mg. Product ID: S5836. Formula: C10H14N4O2. Smiles: CC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Ibrutinib (PCI-32765) | Ibrutinib is a potent and highly selective Brutons tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM in cell-free assays, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc. Ibrutinib is applicable as a Btk ligand in the synthesis of a series of PROTACs including P13I. Group: Inhibitors. Alternative Names: PCI-32765. CAS No. 936563-96-1. Pack Sizes: 5mg. Product ID: S2680. Formula: C25H24N6O2. Smiles: C=CC(=O)N1CCCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| ICG-001 | ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to CREB-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300. ICG-001 induces apoptosis. Group: Inhibitors. CAS No. 780757-88-2 (relative stereochemistry); 847591-62-2 (absolute stereochemistry). Pack Sizes: 5mg. Product ID: S2662. Formula: C33H32N4O4. Smiles: C1CN(C2CN(C(=O)C(N2C1=O)CC3=CC=C(C=C3)O)CC4=CC=CC5=CC=CC=C54)C(=O)NCC6=CC=CC=C6. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| ICI 118551 Hydrochloride (Zenidolol) | Zenidolol (ICI-118551) Hydrochloride is a highly selective β2-adrenergic receptor antagonist with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively. Group: Inhibitors. Alternative Names: ICI-118,551. CAS No. 72795-01-8. Pack Sizes: 5mg. Product ID: S8114. Formula: C17H27NO2.HCl. Smiles: CC1=C2CCCC2=C(C=C1)OCC(C(C)NC(C)C)O.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| IκBα Antibody [L13L21] | IKB alpha,IkB-alpha,IκBα,NFKBIA,NFKBIA/IkB alpha. Group: Antibodies. Alternative Names: NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3; NFKBIA; IKBA; MAD3; NFKBI. Pack Sizes: 20uL. Product ID: F3539. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| IKK-16 | IKK-16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM in cell-free assays, respectively. IKK-16 also inhibits LRRK2 Ser935 phosphorylation in cells and LRRK2 kinase activity in vitro with IC50 of 50 nM. Group: Inhibitors. Alternative Names: IKK Inhibitor VII. CAS No. 873225-46-8. Pack Sizes: 10mg. Product ID: S2882. Formula: C28H29N5OS. Smiles: C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| IL-1β Antibody [H12N7] | IL-1 beta,IL-1 beta (Pro-form),IL-1 beta/IL1B,IL-1 beta/IL-1F2,IL-1β. Group: Antibodies. Alternative Names: Interleukin-1 beta; IL-1 beta; Catabolin; IL1B; IL1F2. Pack Sizes: 20uL. Product ID: F3067. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| IL-6 Antibody [E21C4] | IL-6 Antibody [E21C4]. Group: Antibodies. Pack Sizes: 20uL. Product ID: F2097. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| IL-6 Antibody [F4K18] | IL-6. Group: Antibodies. Alternative Names: Interleukin-6; IL-6; B-cell stimulatory factor 2 (BSF-2); CTL differentiation factor (CDF); Hybridoma growth factor; Interferon beta-2 (IFN-beta-2); IL6; IFNB2. Pack Sizes: 20uL. Product ID: F3023. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Ilomastat (GM6001) | Ilomastat (GM6001) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively. Group: Inhibitors. Alternative Names: Galardin. CAS No. 142880-36-2. Pack Sizes: 5mg. Product ID: S7157. Formula: C20H28N4O4. Smiles: CC(C)CC(CC(=O)NO)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Imatinib (STI571) | Imatinib is a multi-target inhibitor of tyrosine kinase with inhibition for v-Abl, c-Kit and PDGFR, IC50 values are 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib (STI571) induces autophagy. Group: Inhibitors. Alternative Names: STI571, CGP-57148B. CAS No. 152459-95-5. Pack Sizes: 250mg. Product ID: S2475. Formula: C29H31N7O. Smiles: CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Imatinib (STI571) Mesylate | Imatinib Mesylate is an orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib Mesylate (STI571) induces autophagy. Group: Inhibitors. Alternative Names: CGP-57148B,STI571. CAS No. 220127-57-1. Pack Sizes: 250mg. Product ID: S1026. Formula: C29H31N7O.CH4SO3. Smiles: CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Imidazole Ketone Erastin (IKE) | IKE(Imidazole ketone erastin) is a potent, selective, and metabolically stable system xc- inhibitor and inducer of ferroptosis. Group: Inhibitors. Alternative Names: PUN30119. CAS No. 1801530-11-9. Pack Sizes: 2mg. Product ID: S8877. Formula: C35H35ClN6O5. Smiles: CC(C)OC1=C(C=C(C=C1)C(=O)CN2C=CN=C2)N3C(=NC4=CC=CC=C4C3=O)CN5CCN(CC5)C(=O)COC6=CC=C(C=C6)Cl. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Importazole | Importazole is a small molecule inhibitor of the transport receptor importin-β (Karyopherin beta) specifically blocking importin-β-mediated nuclear import. Importazole induces apoptosis and inhibits tumor growth. Group: Inhibitors. CAS No. 662163-81-7. Pack Sizes: 10mg. Product ID: S8446. Formula: C20H22N4. Smiles: CC(C1=CC=CC=C1)NC2=NC(=NC3=CC=CC=C32)N4CCCC4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Infliximab (anti-TNF-alpha) | Infliximab (anti-TNF-alpha) is a purified, recombinant DNA-derived chimeric human-mouse IgG monoclonal antibody that consists of mouse heavy and light chain variable regions combined with human heavy and light chain constant regions. Infliximab neutralizes the biological activity of TNF-α by binding with high affinity to the soluble and transmembrane forms of TNF-α, and inhibits or prevents the effective binding of TNF-α with its receptors. MW=144.2 kDa. Group: Antibodies. CAS No. 170277-31-3. Pack Sizes: 5mg. Product ID: A2019. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| Inobrodib (CCS-1477) | Inobrodib (CCS1477; CBP-IN-1; CBP/p300-IN-4) is a potent and selective inhibitor of p300/CBP bromodomain. CCS1477 works by inhibiting the expression and function of the androgen receptor (AR), as well as inhibiting c-Myc. Group: Inhibitors. Alternative Names: CBP-IN-1, CBP/p300-IN-4. CAS No. 2222941-37-7. Pack Sizes: 5mg. Product ID: S9667. Formula: C30H32F2N4O3. Smiles: CC1=C(C(=NO1)C)C2=CC3=C(C=C2)N(C(=N3)C4CCCC(=O)N4C5=CC(=C(C=C5)F)F)C6CCC(CC6)OC. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| iNOS Antibody [D1F5] | iNOS,iNOS/NOS Type II. Group: Antibodies. Alternative Names: iNOS,iNOS/NOS Type II. Pack Sizes: 20uL. Product ID: F0177. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| iNOS Antibody [G10L10] | iNOS Antibody [G10L10]. Group: Antibodies. Alternative Names: NOS2A; NOS2; Hepatocyte NOS; Inducible NO synthase; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2; HEP-NOS; Inducible NOS; iNOS. CAS No. Pack Sizes: 20uL. Product ID: F4863. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Insulin (human) | Insulin (human) (Insulin regular) is a polypeptide hormone that regulates the level of glucose. Insulin is commonly used to treat hyperglycemia in patients with diabetes. Potency: 29 units/mg. Group: Inhibitors. Alternative Names: Insulin regular. CAS No. 11061-68-0. Pack Sizes: 25mg. Product ID: S6955. Formula: C257H383N65O77S6. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Ionomycin | Ionomycin (SQ23377) is a potent and selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. It induces the activation of protein kinase C (PKC) and promotes apoptosis. Group: Inhibitors. Alternative Names: SQ23377. CAS No. 56092-81-0. Pack Sizes: 5mg. Product ID: S7074. Formula: C41H72O9. Smiles: CC(CCC(=O)O)CC(C)CC(C)C(=O)C=C(C(C)CC(C)CC=CC(C)C(C(C)C(CC1CCC(O1)(C)C2CCC(O2)(C)C(C)O)O)O)O. Storage Conditions: 2 years -20°C liquid. | United States; Europe |
| Ipatasertib (GDC-0068) | Ipatasertib (GDC-0068, RG7440) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM in cell-free assays, 620-fold selectivity over PKA. Phase 2. Group: Inhibitors. Alternative Names: RG7440. CAS No. 1001264-89-6. Pack Sizes: 5mg. Product ID: S2808. Formula: C24H32ClN5O2. Smiles: CC1CC(C2=C1C(=NC=N2)N3CCN(CC3)C(=O)C(CNC(C)C)C4=CC=C(C=C4)Cl)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Ipilimumab (anti-CTLA-4) | Ipilimumab (anti-CTLA-4) is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor. MW : 148 kD. Group: Antibodies. Alternative Names: MDX-010, BMS-734016. CAS No. 477202-00-9. Pack Sizes: 5mg. Product ID: A2001. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. | United States; Europe |
| IRE1α Antibody [B12P6] | IRE1 alpha,IRE1α. Group: Antibodies. Alternative Names: IRE1α. Pack Sizes: 20ul. Product ID: F0229. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| IRF-3 Antibody [N18A4] | IRF3,IRF-3. Group: Antibodies. Alternative Names: IRF-3. CAS No. Pack Sizes: 20ul. Product ID: F0521. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Irinotecan (CPT-11) | Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively. Group: Inhibitors. Alternative Names: (+)-Irinotecan,CPT-11. CAS No. 97682-44-5. Pack Sizes: 100mg. Product ID: S1198. Formula: C33H38N4O6. Smiles: CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Irinotecan Hydrochloride Trihydrate | Irinotecan HCl Trihydrate is a hydrochloride trihydrate of irinotecan (Camptosar, Campto, CPT-11) which is a topoisomerase I inhibitor with IC50 of 15.8 and 5.17 μM for LoVo cells and HT-29 cells, respectively. Group: Inhibitors. Alternative Names: CPT-11 HCl Trihydrate. CAS No. 136572-09-3. Pack Sizes: 5mg. Product ID: S2217. Formula: C33H38N4O6.HCl.3H2O. Smiles: CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.O.O.O.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Isoprenaline (Isoproterenol) HCl | Isoprenaline (Isoproterenol) HCl is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block. Group: Inhibitors. Alternative Names: NCI-C55630 HCl. CAS No. 51-30-9. Pack Sizes: 50mg. Product ID: S2566. Formula: C11H17NO3.HCl. Smiles: CC(C)NCC(C1=CC(=C(C=C1)O)O)O.Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| ISRIB | ISRIB is an integrated stress response (ISR) inhibitor that potently reverses the effects of eukaryotic initiation factor 2α (eIF2α) phosphorylation. Group: Inhibitors. CAS No. 548470-11-7. Pack Sizes: 5mg. Product ID: S0706. Formula: C22H24Cl2N2O4. Smiles: ClC1=CC=C(OCC(=O)NC2CCC(CC2)NC(=O)COC3=CC=C(Cl)C=C3)C=C1. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| ISRIB (trans-isomer) | ISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM and does not have global effects on translation, transcription, or mRNA stability in non-stressed cells. Group: Inhibitors. CAS No. 1597403-47-8. Pack Sizes: 10mg. Product ID: S7400. Formula: C22H24Cl2N2O4. . . Smiles: C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| ISX-9 (Isoxazole 9) | Isoxazole 9 (Isx-9) is a synthetic promotor of adult neurogenesis by triggering neuronal differentiation of adult neural stem / precursor cells (NSPCs). Isoxazole 9 (Isx-9) activates multiple pathways including TGF-β induced epithelial-mesenchymal transition (EMT) signaling, canonical and non-canonical Wnt signaling at different stages of cardiac differentiation. Group: Inhibitors. CAS No. 832115-62-5. Pack Sizes: 5mg. Product ID: S7914. Formula: C11H10N2O2S. Smiles: C1CC1NC(=O)C2=NOC(=C2)C3=CC=CS3. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
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