BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Cyt387 | Cyt387 is an ATP-competitive inhibitor of JAK1 and JAK2 (IC50 = 11 nM and 18 nM respectively). It has been shown to decrease cancer stem cell associated tumor burden in a mouse model of human ovarian cancer. It is commonly used as a therapy for myelofibrosis. Uses: An orally bioavailable small-molecule inhibitor of janus kinases 1 and 2 (jak1/2) with potential antineoplastic activity (ic50s = 11 and 18 nm, respectively). Alternative Names: Momelotinib; N-(Cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]benzamide; CYT 11387; CYT 387; CYT-387; CYT387; CYT-0387; GS 0387. Grades: >98%. CAS No. 1056634-68-4. Molecular formula: C23H22N6O2. Mole weight: 414.46. |  |
| CZ415 | CZ415 is a highly selective potent mTOR inhibitor with little activity on other lipid and protein kinases with efficacy in a collagen induced arthritis model and exhibits excellent cell permeability. In the issue, Bergamini et al., who has identified CZ415, confirmed with its extraordinary selectivity, drug-like properties and proven efficacy in vivo, CZ415 represents an ideal molecule for the pharmacological investigation of mTOR pathophysiological role in vivo. Assessed in dose response format from HEK293T cells after treatment with CZ415: 1. inhibition of S6RP (downstream of mTORC1) phosphorylation in HEK293T: IC50 = 14.5 nM; 2. inhibition of Akt (mTORC2 substrate) phosphorylation in HEK293T: IC50 = 14.8 nM; 3. inhibition of IFNγ release in stimulated human whole blood: IC50 = 226 nM. Alternative Names: CZ415; CZ-415; CZ 415; (S)-1-(4-(7,7-dimethyl-4-(3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea. CAS No. 1429639-50-8. Molecular formula: C22H29N5O4S. Mole weight: 459.57. | |
| Dabigatran etexilate | Dabigatran etexilate(BIBR-1048) is the orally active prodrug of dabigatran; Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM. Uses: Antithrombins. Alternative Names: Prazaxa; BIBR 1048; BIBR-1048. Grades: 99%. CAS No. 211915-06-9. Molecular formula: C34H41N7O5. Mole weight: 627.75. | |
| Dabigatran Etexilate Impurity 1 | An impurity of Dabigatran Ethyl Ester, a nonpeptide, direct thrombin inhibitor. Alternative Names: O-Desethyl O-Isopropyl Dabigatran Etexilate. Grades: > 95%. CAS No. 1610758-19-4. Molecular formula: C35H43N7O5. Mole weight: 641.78. | |
| Dabigatran Etexilate Impurity 2 | O-(2-Ethylbutyl) Dabigatran Ethyl Ester is an impurity of Dabigatran Ethyl Ester, a nonpeptide, direct thrombin inhibitor. Alternative Names: O-(2-Ethylbutyl) Dabigatran Ethyl Ester; N-[[2-[[[4-[[[(2-Ethylbutoxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-Alanine Ethyl Ester. Grades: > 95%. CAS No. 1610758-20-7. Molecular formula: C34H41N7O5. Mole weight: 627.73. | |
| Dabigatran Etexilate N-Oxide Inner Salt | Dabigatran Etexilate N-Oxide is a metabolite of Dabigatran Etexilate, an oral anticoagulant and direct thrombin inhibitor. Alternative Names: N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(1-oxido-2-pyridinyl)-β-Alanine Ethyl Ester. Grades: > 95%. CAS No. 1381757-44-3. Molecular formula: C34H41N7O6. Mole weight: 643.73. | |
| Dabigatran ethyl AcOH Salt | Dabigatran ethyl AcOH Salt, a remarkable pharmaceutical compound, plays a pivotal role in studying blood clots, encompassing deep vein thrombosand pulmonary embolism. It exerts its profound anticoagulant effects through targeted inhibition of thrombin, a pivotal enzyme in the intricate clotting cascade. Alternative Names: Ethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate acetate. CAS No. 1188263-64-0. Molecular formula: C29H33N7O5. Mole weight: 559.627. | |
| Dabigatran ethyl ester hydrochloride | A derivative of Dabigatran, which acts as a non-peptide, direct thrombin inhibitor. Alternative Names: Dabigatran Impurity O HCl; Dabigatran Ethyl Ester Hydrochloride Salt; Ethyl 3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate hydrochloride. Grades: >95%. CAS No. 211914-50-0. Molecular formula: C27H30ClN7O3. Mole weight: 536.03. | |
| Dabigatran impurity 002 | An impurity of Dabigatran. Dabigatran is a very potent anticoagulant, shows that the terminal phenyl can be substituted by the more hydrophilic 2-pyridyl group without substantial loss of activity. Molecular formula: C11H10N2O4. Mole weight: 234.21. | |
| Dabigatran impurity 004 | An impurity of Dabigatran. Dabigatran is a very potent anticoagulant, shows that the terminal phenyl can be substituted by the more hydrophilic 2-pyridyl group without substantial loss of activity. Molecular formula: C16H18N4O4. Mole weight: 330.34. | |
| Dabigatran impurity 005 | An impurity of Dabigatran. Dabigatran is a very potent anticoagulant, shows that the terminal phenyl can be substituted by the more hydrophilic 2-pyridyl group without substantial loss of activity. Molecular formula: C16H16N4O5. Mole weight: 344.32. | |
| Dabigatran impurity 006 | An impurity of Dabigatran. Dabigatran is a very potent anticoagulant, shows that the terminal phenyl can be substituted by the more hydrophilic 2-pyridyl group without substantial loss of activity. Molecular formula: C17H18N4O5. Mole weight: 358.35. | |
| Dabigatran Impurity 20 | An impurity of Dabigatran. Dabigatran is a very potent anticoagulant, shows that the terminal phenyl can be substituted by the more hydrophilic 2-pyridyl group without substantial loss of activity. Alternative Names: Dabigatran Impurity 007 . Grades: 95%. CAS No. 1408238-39-0. Molecular formula: C33H39N7O5. Mole weight: 613.71. | |
| Dabigatran Impurity 50 | An impurity of Dabigatran. Dabigatran is a very potent anticoagulant, shows that the terminal phenyl can be substituted by the more hydrophilic 2-pyridyl group without substantial loss of activity. Alternative Names: Dabigatran impurity 003. Molecular formula: C16H18N4O3. Mole weight: 314.33. | |
| Dabigatran Impurity E | O-(2-Heptyl) Dabigatran Ethyl Ester is an impurity of Dabigatran Ethyl Ester, a nonpeptide, direct thrombin inhibitor. Alternative Names: O-(2-Heptyl) Dabigatran Ethyl Ester; Ethyl 3-(2-(((4-(N-((Heptan-2-yloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate. Grades: > 95%. CAS No. 1610758-21-8. Molecular formula: C35H43N7O5. Mole weight: 641.76. | |
| Dabigatran Impurity H | Des-(N-2-pyridyl-β-alanine ethyl ester) Dabigatran etexilate 5-ethyl carboxylate is a derivative of Dabigatran, an oral thrombin inhibitor used to prevent venous thromboembolism. Alternative Names: Des-(N-2-pyridyl-β-alanine Ethyl Ester) Dabigatran Etexilate 5-Ethyl Carboxylate; 2-[[[4-[[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazole-5-carboxylic Acid Ethyl Ester. Grades: > 95%. CAS No. 1408238-36-7. Molecular formula: C26H33N5O4. Mole weight: 479.57. | |
| Dabigatran Impurity K | An impurity of Dabigatran, an anticoagulant used to treat and prevent blood clots. Grades: > 95%. CAS No. 211915-00-3. Molecular formula: C33H39N7O5. Mole weight: 613.72. | |
| Dacarbazine | Dacarbazine is an antineoplastic chemotherapy drug used in the treatment of various cancers.Dacarbazine is a member of the class of alkylating agents, which destroy cancer cells by adding an alkyl group (CnH2n+1) to its DNA. Uses: Anti-tumor. Alternative Names: DTIC-Dome. Grades: >98%. CAS No. 4342-3-4. Molecular formula: C6H10N6O. Mole weight: 182.18. | |
| Daclatasvir dihydrochloride | Daclatasvir is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture. Alternative Names: Methyl N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate dihydrochloride; Daclatasvir; BMS790052; BMS 790052; BMS-790052; EBP883; EBP 883; EBP-883; Daklinza. Grades: >98%. CAS No. 1009119-65-6. Molecular formula: C40H50N8O6·2HCl. Mole weight: 811.8. | |
| Dacomitinib | Dacomitinib, aslo known as PF-299 and PF-00299804; or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells. EGFRs play major roles in tumor cell proliferation and tumor vascularization, and are often overexpressed or mutated in various tumor cell types. Alternative Names: dacomitinib; PF-00299804; PF00299804; PF 00299804; PF299804; PF-299804; PF 299804; PF-299; PF 299; PF299. CAS No. 1110813-31-4. Molecular formula: C24H25ClFN5O2. Mole weight: 469.945. | |
| DAF-2 | DAF-2 is a fluorescent indicator for the detection of nitric oxide (NO). Alternative Names: DAF-2-CAS 205391-01-1-Calbiochem;4,5-Diaminofluorescein; 2-(3,6-dihydroxy-4,5-diamino-9H-xanthen-9-yl)-benzoic acid. Grades: ≥98%. CAS No. 205391-01-1. Molecular formula: C20H14N2O5. Mole weight: 362.3. | |
| Daidzin 6''-O-malonate | Daidzin 6''-O-malonate is a biomedical product used in the treatment of alcohol dependency and cancer. It is derived from daidzein, a natural compound found in plants. Daidzin 6''-O-malonate targets specific receptors in the brain, reducing the craving for alcohol. Alternative Names: Malonyldaidzin; 6''-O-Malonyldaidzin. CAS No. 124590-31-4. Molecular formula: C24H22O12. Mole weight: 502.42. | |
| D-Ala(18)-Semaglutide | D-Ala(18)-Semaglutide is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Alternative Names: [D-Ala18]-Semaglutide; (3S,9S,12S,15S,18S,21S,24S,27S,30S,33S,36S,39S,45S,48R,51S,54S,81R)-54-(((6S,12S,15S,18S,21S,24S,27S,30S,33S)-21-((1H-indol-3-yl)methyl)-1-amino-30-benzyl-27-((S)-sec-butyl)-35-carboxy-6-((carboxymethyl)carbamoyl)-12-(3-guanidinopropyl)-1-imino-18-isobutyl-15-isopropyl-24-methyl-8,11,14,17,20,23,26,29,32-nonaoxo-2,7,10,13,16,19,22,25,28,31-decaazapentatriacontan-33-yl)carbamoyl)-3-(2-((S)-2-amino-3-(1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-45-(3-amino-3-oxopropyl)-12-benzyl-39-(2-carboxyethyl)-21-(carboxymethyl)-33-(4-hydroxybenzyl)-9,15-bis((R)-1-hydroxyethyl)-18,27,30-tris(hydroxymethyl)-36-isobutyl-24-isopropyl-48,51-dimethyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,60,69,78,83-henicosaoxo-62,65,71,74-tetraoxa-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,59,68,77,82-henicosaazanonanonacontane-1,81,99-tricarboxylic acid. Grades: 95%. Molecular formula: C187H291N45O59. Mole weight: 4113.64. | |
| D-Ala(19)-Semaglutide | D-Ala(19)-Semaglutide is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Alternative Names: D-Ala-19-Semaglutide; (3S,9S,12S,15S,18S,21S,24S,27S,30S,33S,36S,39S,45S,48S,51R,54S,81R)-54-(((6S,12S,15S,18S,21S,24S,27S,30S,33S)-21-((1H-indol-3-yl)methyl)-1-amino-30-benzyl-27-((S)-sec-butyl)-35-carboxy-6-((carboxymethyl)carbamoyl)-12-(3-guanidinopropyl)-1-imino-18-isobutyl-15-isopropyl-24-methyl-8,11,14,17,20,23,26,29,32-nonaoxo-2,7,10,13,16,19,22,25,28,31-decaazapentatriacontan-33-yl)carbamoyl)-3-(2-((S)-2-amino-3-(1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-45-(3-amino-3-oxopropyl)-12-benzyl-39-(2-carboxyethyl)-21-(carboxymethyl)-33-(4-hydroxybenzyl)-9,15-bis((R)-1-hydroxyethyl)-18,27,30-tris(hydroxymethyl)-36-isobutyl-24-isopropyl-48,51-dimethyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,60,69,78,83-henicosaoxo-62,65,71,74-tetraoxa-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,59,68,77,82-henicosaazanonanonacontane-1,81,99-tricarboxylic acid. Grades: 95%. Molecular formula: C187H291N45O59. Mole weight: 4113.64. | |
| D-Ala(24)-Semaglutide | D-Ala(24)-Semaglutide is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Alternative Names: D-Ala-24-Semaglutide; (3S,9S,12S,15S,18S,21S,24S,27S,30S,33S,36S,39S,45S,48S,51S,54S,81R)-54-(((6S,12S,15S,18S,21S,24R,27S,30S,33S)-21-((1H-indol-3-yl)methyl)-1-amino-30-benzyl-27-((S)-sec-butyl)-35-carboxy-6-((carboxymethyl)carbamoyl)-12-(3-guanidinopropyl)-1-imino-18-isobutyl-15-isopropyl-24-methyl-8,11,14,17,20,23,26,29,32-nonaoxo-2,7,10,13,16,19,22,25,28,31-decaazapentatriacontan-33-yl)carbamoyl)-3-(2-((S)-2-amino-3-(1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-45-(3-amino-3-oxopropyl)-12-benzyl-39-(2-carboxyethyl)-21-(carboxymethyl)-33-(4-hydroxybenzyl)-9,15-bis((R)-1-hydroxyethyl)-18,27,30-tris(hydroxymethyl)-36-isobutyl-24-isopropyl-48,51-dimethyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,60,69,78,83-henicosaoxo-62,65,71,74-tetraoxa-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,59,68,77,82-henicosaazanonanonacontane-1,81,99-tricarboxylic acid. Grades: 95%. Molecular formula: C187H291N45O59. Mole weight: 4113.64. | |
| (D-Ala2,D-Leu5)-Enkephalin Trifluoroacetate | (D-Ala2,D-Leu5)-Enkephalin is a prototypical δ-opioid receptor agonist with antinociceptive activity. It also exhibits activity at the μ-opioid receptor. Alternative Names: L-tyrosyl-D-alanyl-glycyl-L-phenylalanyl-D-leucine trifluoroacetic acid; (D-Ala2,D-Leu5)-Enkephalin TFA salt; DADLE TFA salt. Molecular formula: C31H40F3N5O9. Mole weight: 683.67. | |
| Dalcetrapib | Dalcetrapib is a potent CETP inhibitor that increases the HDL level and decreases the VLDL level in plasma. It exhibits cardiovascular protective property. Uses: Anticholesteremic agents. Alternative Names: JTT-705; JTT705; JTT 705; RO-4607381; RO4607381; RO 4607381; S-[2-[[1-(2-ethylbutyl)cyclohexanecarbonyl]amino]phenyl] 2-methylpropanethioate. Grades: >98%. CAS No. 211513-37-0. Molecular formula: C23H35NO2S. Mole weight: 389.59. | |
| D-Allo-Thr(5)-Semaglutide | D-Allo-Thr(5)-Semaglutide is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Alternative Names: His-Aib-Glu-Gly-D-Allo-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys (AEEAc-AEEAc-γ-Glu-17-carboxy heptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH. Grades: 95%. Molecular formula: C187H291N45O59. Mole weight: 4113.64. | |
| D-allo-Thr(6)-Octreotide trifluoroacetate salt | D-allo-Thr(6)-Octreotide is an impurity of Octreotide, which is a synthetic long-acting cyclic octapeptide used as a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Grades: 95%. | |
| D-Allo-Thr(7)-Semaglutide | D-Allo-Thr(7)-Semaglutide is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Alternative Names: H-His-Aib-Glu-Gly-Thr-Phe-D-Allo-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH. Grades: 95%. Molecular formula: C187H291N45O59. Mole weight: 4113.64. | |
| Dantrolene Impurity 2 | 5-(4-Nitrophenyl)-2-furaldehyde-(2-carboxymethyl) Semicarbazone is an impurity in the synthesis of Dantrolene, a muscle relaxant (skeletal). Dantrolene is used in the treatment of malignant hyperthermia. Alternative Names: 5-(4-Nitrophenyl)-2-furaldehyde-(2-carboxymethyl) Semicarbazone; [(Aminocarbonyl)[[5-(4-nitrophenyl)-2-furanyl]methylene]hydrazino]acetic Acid; Dantrolene Impurity. Grades: > 95%. CAS No. 57268-33-4. Molecular formula: C14H12N4O6. Mole weight: 332.27. | |
| DAP-81 | DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50 of 0.9 nM. DAP-81 is currently in ongoing preclinical evaluations. Alternative Names: DAP81; DAP 81; DAP-81. N-(4-((4-((2-benzoylphenyl)amino)-5-nitropyrimidin-2-yl)amino)phenyl)acetamide. Grades: 98%. CAS No. 794466-17-4. Molecular formula: C25H20N6O4. Mole weight: 468.464. | |
| Dapagliflozin-[d5] | Dapagliflozin-[d5] is a labelled analogue of Dapagliflozin. Dapagliflozin is a selective sodium-glucose cotransporter-2 inhibitor that reduces renal glucose reabsorption and is used to treat patients with type 2 diabetes. Alternative Names: Dapagliflozin D5. Grades: 95% by HPLC; 95% atom D. CAS No. 1204219-80-6. Molecular formula: C21H20D5ClO6. Mole weight: 413.90. | |
| Dapagliflozin Dimer | Dapagliflozin Dimer is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Alternative Names: Dapagliflozin Sugar Dimer. CAS No. 2452300-79-5. Molecular formula: C42H48Cl2O12. Mole weight: 815.73. | |
| Dapagliflozin Furanose Isomer | Dapagliflozin Furanose Isomer is an impurity of Dapagliflozin. Dapagliflozin (BMS 512148) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Alternative Names: Dapagliflozin 1,4-Anhydro impurity; (1S)-1,4-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol. Grades: >95%. CAS No. 1469910-70-0. Molecular formula: C21H25ClO6. Mole weight: 408.87. | |
| Dapagliflozin Impurity 17 | Dapagliflozin Impurity 17 is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Alternative Names: 1,4-Dibromo-2-[(4-ethoxyphenyl)methyl]benzene. Grades: >95%. CAS No. 1807632-93-4. Molecular formula: C15H14Br2O. Mole weight: 370.08. | |
| Dapagliflozin Methyl Acetate | Dapagliflozin Methyl Acetate is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Alternative Names: Dapagliflozin MonoAcetyl Impurity; ((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)methyl acetate. Grades: >90%. CAS No. 1632287-34-3. Molecular formula: C23H27ClO7. Mole weight: 450.91. | |
| Dapagliflozin Open Ring | Dapagliflozin Open Ring is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Alternative Names: 1-C-[4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol; Dapagliflozin Impurity 5 (Mixture of Diastereomers). Grades: >90%. CAS No. 2100872-88-4. Molecular formula: C21H27ClO7. Mole weight: 426.89. | |
| Daphmacropodine | Daphmacropodine is isolated from the branch of Daphniphyllum macropodum Miq. Alternative Names: (1S,2S,5S,7R,8R)-7-Hydroxy-8-{2-[(1S,2R,3S,7R,10S,13S,14R)-14-isopropyl-1-methyl-12-azapentacyclo[8.6.0.02,13.03,7.07,12]hexadec-2-yl]ethyl}-1,5-dimethyl-6-oxabicyclo[3.2.1]oct-2-yl acetate. Grades: 97.5%. CAS No. 39729-21-0. Molecular formula: C32H51NO4. Mole weight: 513.8. | |
| Daphnicyclidin D | Daphnicyclidin D is an alkaloid isolated from the stems of Daphniphyllum humile and D.teijsmanni. Alternative Names: Daphnicyclidine D;1,12-Methanopyrano[4',3',2':1,8]azuleno[4,5-a]indolizine-2-carboxylic acid, 3,4,6,7,7a,8,10,11,12,13,13a,13b-dodecahydro-11,13b-dimethyl-14-oxo-, methyl ester, (7aS,9S,11S,12R,13aR,13bS)-. CAS No. 385384-24-7. Molecular formula: C23H27NO4. Mole weight: 381.472. | |
| Daphnilongeranin A | Daphnilongeranin A is isolated from the branch of Daphniphyllum macropodum Miq. Alternative Names: Daphnilongeranin A; 874201-05-5; Methyl (1s,2s,3r,5r,6s,10s)-2,6-dimethyl-21-oxo-14-oxa-8-azahexacyclo[11.6.1.11,5.02,10.03,8.017,20]henicosa-13(20),17-diene-18-carboxylatedaphnilongeranins AZINC96023819. Grades: 97.5%. CAS No. 874201-05-5. Molecular formula: C23H29NO4. Mole weight: 383.5. | |
| Daphnilongeranin C | Daphnilongeranin C is isolated from the herbs of Daphniphyllum longeracemosum. Alternative Names: Daphnilongeranin C; 750649-07-1; (1r,2s,3r,5r,6s,10s,16r,17r)-2,6-dimethyl-20-oxo-8-azahexacyclo[11.5.1.11,5.02,10.03,8.016,19]icos-13(19)-ene-17-carboxylic Acid; daphnilongeranins C; ZINC96023636. Grades: 98%. CAS No. 750649-07-1. Molecular formula: C22H29NO3. Mole weight: 355.5. | |
| Daphnilongeridine | Daphnilongeridine is isolated from the branch of Daphniphyllum macropodum Miq. Uses: Cytotoxicity. Alternative Names: Daphnilongeridine; 922522-15-4; [(1S,2S,5S,7R,8R)-7-hydroxy-1,5-dimethyl-8-[2-[(1S,2R,3R,7R,10S,11R,13S,14R)-1-methyl-14-propan-2-yl-12-azapentacyclo[8.6.0.02,13.03,7.07,11]hexadecan-2-yl]ethyl]-6-oxabicyclo[3.2.1]octan-2-yl] acetate. Grades: 95%. CAS No. 922522-15-4. Molecular formula: C32H51NO4. Mole weight: 513.8. | |
| Daphniyunnine A | Daphniyunnine A is isolated from the leaves and stems of Daphniphyllum macropodum Miq. Alternative Names: 1H-11,12c-Methanocyclopent[1,8]azuleno[4,5-a]indolizine-2-carboxylic acid, 2,2a,3,4,5,6,6a,7,9,10,11,12,12a,12b-tetradecahydro-13-oxo-10,12b-dimethyl-, methyl ester, (2R,2aR,6aS,8S,10S,11R,12aR,12bS,12cR)-. Grades: 98%. CAS No. 881388-87-0. Molecular formula: C23H31NO3. Mole weight: 369.5. | |
| Daphniyunnine B | Daphniyunnine B is isolated from the leaves and stems of Daphniphyllum macropodum Miq. Alternative Names: 4H-11,12c-Methanoazuleno[4,5-a]indolizine-4,13-dione, 1,2,5,6,6a,7,9,10,11,12,12a,12b-dodecahydro-3-(2-hydroxyethyl)-10,12b-dimethyl-, (6aS,8S,10S,11R,12aR,12bS,12cS)-. CAS No. 881388-88-1. Molecular formula: C21H29NO3. Mole weight: 343.5. | |
| Daphnoretin | Daphnoretin is isolated from the roots of Wikstroemia indica (Linn.) C. A. Mey. Uses: Antiviral activity; anticancer effects; antitumor. Alternative Names: 7-Hydroxy-6-methoxy-3-[(2-oxo-2H-1-benzopyran-7-yl)-oxy]-2H-1-benzopyran-2-one. Grades: 98%. CAS No. 2034-69-7. Molecular formula: C19H12O7. Mole weight: 352.3. | |
| Dapivirine | Dapivirine, also known as TMC 120, TMC 120 R147681, is a NNRTI for HIV reverse transcriptase with IC50 of 24 nM, inhibiting a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Alternative Names: TMC120; TMC 120; TMC-120; R 147681; R-147681; R147681; Dapivirine. Grades: 99.90%. CAS No. 244767-67-7. Molecular formula: C20H19N5. Mole weight: 329.407. | |
| Dapoxetine Impurity 1 | An impurity of Dapoxetine. Dapoxetine HCl is a short-acting novel selective serotonin reuptake inhibitor. Alternative Names: 3,4-Dihydro-4-phenyl-2H-benzo[h]chromene. Grades: 95%. CAS No. 94305-25-6. Molecular formula: C19H16O. Mole weight: 260.33. | |
| Dapoxetine Impurity 2 | An impurity of Dapoxetine. Dapoxetine HCl is a short-acting novel selective serotonin reuptake inhibitor. Grades: 95%. CAS No. 2242008-37-1. Molecular formula: C30H31NO2. Mole weight: 437.57. | |
| Dapoxetine Impurity 24 | An impurity of Dapoxetine. Dapoxetine HCl is a short-acting novel selective serotonin reuptake inhibitor. Alternative Names: α-[2-(1-Naphthalenyloxy)ethyl]benzenemethanol; 3-(1-Naphthalenyloxy)-1-phenylpropan-1-ol. Grades: 95%. CAS No. 908291-72-5. Molecular formula: C19H18O2. Mole weight: 278.34. | |
| Dapoxetine Impurity 2 hydrochloride | An impurity of Dapoxetine. Dapoxetine HCl is a short-acting novel selective serotonin reuptake inhibitor. Grades: 95%. CAS No. 2242008-38-2. Molecular formula: C30H32NO2Cl. Mole weight: 474.03. | |
| Dapoxetine Impurity 8 | An impurity of Dapoxetine. Dapoxetine HCl is a short-acting novel selective serotonin reuptake inhibitor. Alternative Names: Dapoxetine Impurity 004. Grades: 95%. CAS No. 2245197-07-1. Molecular formula: C30H31NO. Mole weight: 421.57. | |
| D-Arg(28)-Semaglutide | D-Arg(28)-Semaglutide is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Alternative Names: D-Arg-28-Semaglutide. Grades: 95%. Molecular formula: C187H291N45O59. Mole weight: 4113.64. | |
| [D-Arg30]-Semaglutide | [D-Arg30]-Semaglutide is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Alternative Names: (3S,9S,12S,15S,18S,21S,24S,27S,30S,33S,36S,39S,45S,48S,51S,54S,81R)-54-(((6R,12S,15S,18S,21S,24S,27S,30S,33S)-21-((1H-indol-3-yl)methyl)-1-amino-30-benzyl-27-((S)-sec-butyl)-35-carboxy-6-((carboxymethyl)carbamoyl)-12-(3-guanidinopropyl)-1-imino-18-isobutyl-15-isopropyl-24-methyl-8,11,14,17,20,23,26,29,32-nonaoxo-2,7,10,13,16,19,22,25,28,31-decaazapentatriacontan-33-yl)carbamoyl)-3-(2-((S)-2-amino-3-(1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-45-(3-amino-3-oxopropyl)-12-benzyl-39-(2-carboxyethyl)-21-(carboxymethyl)-33-(4-hydroxybenzyl)-9,15-bis((R)-1-hydroxyethyl)-18,27,30-tris(hydroxymethyl)-36-isobutyl-24-isopropyl-48,51-dimethyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,60,69,78,83-henicosaoxo-62,65,71,74-tetraoxa-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,59,68,77,82-henicosaazanonanonacontane-1,81,99-tricarboxylic acid. Grades: 95%. Molecular formula: C187H291N45O59. Mole weight: 4113.64. | |
| Darunavir Ethanolate | Darunavir Ethanolate is a nonpeptidic HIV protease inhibitor, used to treat HIV infection. Uses: Hiv protease inhibitors. Alternative Names: Phosphonoformate. Grades: >98%. CAS No. 635728-49-3. Molecular formula: C27H37N3O7S·C2H5OH. Mole weight: 593.73. | |
| Darusentan | Darusentan is a selective endothelin-1 receptor A inhibitor. Darusentan is identified as the treatment of congestive heart failure, hypertension and cancers. It blocks endothelin ETA receptor thus results in an increase of sodium and potassium excretion in aging rats. Uses: Endothelin receptor antagonists. Alternative Names: LU-135252; LU135252; LU 135252; HMR-4005; HMR 4005; HMR4005; (2S)-2-(4,6-dimethoxypyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid. Grades: 95%. CAS No. 171714-84-4. Molecular formula: C22H22N2O6. Mole weight: 410.426. | |
| dasabuvir | Dasabuvir is an antiviral drug for the treatment of hepatitis C. It inhibits hepatitis C virus (HCV) non-nucleoside NS5B palm polymerase to suppress RNA replicase. Dasabuvir is commonly used in combination with ombitasvir / paritaprevir / ritonavir to effect on HCV type 1. Uses: The treatment of hepatitis c. Alternative Names: ABT333; ABT-333; ABT 333, Dasabuvir. Trade names: Viekira Pak (with ombitasvir / paritaprevir / ritonavir tablets), Exviera; N-(6-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide. Grades: 98.40%. CAS No. 1132935-63-7. Molecular formula: C26H27N3O5S. Mole weight: 493.578. | |
| Dasatinib N-Oxide | Dasatinib N-Oxide is an oxidative metabolite of Dasatinib (M5 metabolite). Alternative Names: N-[2-Chloro-6-methylphenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide N-Oxide. Grades: > 95%. CAS No. 910297-52-8. Molecular formula: C22H26ClN7O3S. Mole weight: 504. | |
| Dasotraline hydrochloride | Dasotraline hydrochloride, also called as SEP-225289 hydrochloride, is a metabolite of Sertraline and a novel inhibitor of dopamine and norepinephrine reuptake that blocks dopamine, norepinephrine, andserotonin transporters (IC50 = 4, 6, and 11 nM, respectively). Alternative Names: (1R,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine;hydrochloride; SEP-225,289; SEP225,289; SEP225,289; SEP-225289; SEP225289; SEP225289;; Dasotraline; Dasotraline HCl; Dasotraline hydrochloride. CAS No. 675126-08-6. Molecular formula: C16H16Cl3N. Mole weight: 328.66. | |
| D-Asp(9)-Semaglutide | D-Asp(9)-Semaglutide is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Alternative Names: (3S,9S,12S,15S,18S,21R,24S,27S,30S,33S,36S,39S,45S,48S,51S,54S,81R)-54-(((6S,12S,15S,18S,21S,24S,27S,30S,33S)-21-((1H-indol-3-yl)methyl)-1-amino-30-benzyl-27-((S)-sec-butyl)-35-carboxy-6-((carboxymethyl)carbamoyl)-12-(3-guanidinopropyl)-1-imino-18-isobutyl-15-isopropyl-24-methyl-8,11,14,17,20,23,26,29,32-nonaoxo-2,7,10,13,16,19,22,25,28,31-decaazapentatriacontan-33-yl)carbamoyl)-3-(2-((S)-2-amino-3-(1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-45-(3-amino-3-oxopropyl)-12-benzyl-39-(2-carboxyethyl)-21-(carboxymethyl)-33-(4-hydroxybenzyl)-9,15-bis((R)-1-hydroxyethyl)-18,27,30-tris(hydroxymethyl)-36-isobutyl-24-isopropyl-48,51-dimethyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,60,69,78,83-henicosaoxo-62,65,71,74-tetraoxa-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,59,68,77,82-henicosaazanonanonacontane-1,81,99-tricarboxylic acid. Grades: 95%. Molecular formula: C187H291N45O59. Mole weight: 4113.64. | |
| Daturabietatriene | Daturabietatriene is isolated from the heartwoods of Pinus yunnanensis. Alternative Names: Abieta-8,11,13-triene-15,18-diol. Grades: 96.5%. CAS No. 65894-41-9. Molecular formula: C20H30O2. Mole weight: 302.5. | |
| DAURICINE | Dauricine had a good inhibition effect on tumor cells in urinary system. At the same time, Dauricine has certain inhibition effects on the primary cultured tumor cell. Uses: Antiarrhythmic. Alternative Names: 4-[[(1R)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]phenoxy]phenol; 4-[((1R)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl)methyl]-2-[4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl]methyl]phenoxy]phenol; Dauricine; dauricine (8ci); Menispermum dauricum DC Extract; 6,6'-Di-O-Methyldauricoline. Grades: >98%. CAS No. 524-17-4. Molecular formula: C38H44N2O6. Mole weight: 624.77. | |
| DBCO-PEG4-vc-PAB-MMAF | DBCO-PEG4-vc-PAB-MMAF is a drug-linker conjugate for ADC by using Monomethylauristatin F (MMAF, a potent tubulin polymerization inhibitor), linked via DBCO-PEG4-vc-PAB. Molecular formula: C88H126N12O20. Mole weight: 1672.04. | |
| DBeQ | DBeQ inhibits p97 competitively with respect to ATP, with Ki of 3.2 μM, suggesting that it binds to the active site of the D2 domain. Alternative Names: DBeQ; DBEQ; JRF12; JRF-12; JRF 12. Grades: >98%. CAS No. 177355-84-9. Molecular formula: C22H20N4. Mole weight: 340.42. | |
| dBET1 | dBET1 is a potent BRD4 protein degrader composed of a BET bromodomain inhibitor (+)-JQ1 and a sedative drug thalidomide. The (+)-JQ1 portion binds to the BET bromodomains, and the thalidomide binds to cereblon to form a cereblon E3 ubiquitin ligase complex, inducing cereblon-dependent BET protein degradation. Alternative Names: (6S)-4-(4-chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide. Grades: 98%. CAS No. 1799711-21-9. Molecular formula: C38H37ClN8O7S. Mole weight: 785.27. | |
| DC-1 | DC-1 is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates. Alternative Names: (S)-5-amino-N-(2-(1-(chloromethyl)-5-hydroxy-2,3-dihydro-1H-benzo[e]indole-3-carbonyl)-1H-indol-5-yl)-1H-indole-2-carboxamide. Grades: ≥95%. Molecular formula: C31H24ClN5O3. Mole weight: 550.01. | |
| DCC-2618 | DCC-2618 inhibits normal and mutant KIT kinase at the nanomol level. The targets are wt c-KIT, c-KIT mutants, PDGFR alpha, PDGFR beta, KDR and cFMS. DCC-2618 inhibits mutant KIT in GIST patient cell line (GIST T1 pKIT western Ex11 deletion) at a IC 50 of 2 nM. Deciphera's technology has identified DCC-2618 as a molecule which can be developed as second line therapy for imatinib and sunitinib resistant GIST patients with the potential to progress to frontline GIST therapy. DCC-2618 has been designed to effectively inhibit the imatinib and sunitinib-sensitive KIT juxtamembrane domain mutants (JMD) as well as secondary resistant KIT kinase-domain mutants. DCC-2618 additionally targets PDGFR alpha oncogenic mutants. Alternative Names: DCC2618; DCC 2618; c-Kit-IN-1; PDGFR inhibitor 1; N-[2,5-Difluoro-4-[[2-(1-methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]phenyl]-N'-phenyl-1,1-cyclopropanedicarboxamide. Grades: >98%. CAS No. 1225278-16-9. Molecular formula: C26H21F2N5O3. Mole weight: 489.47. | |
| D-Cys(2)-Octreotide trifluoroacetate salt | D-Cys(2)-Octreotide is an impurity of Octreotide, which is a synthetic long-acting cyclic octapeptide used as a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Alternative Names: H-D-Phe-D-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-ol trifluoroacetate salt (Disulfide bridge: Cys2-Cys7); Octreotide EP Impurity G trifluoroacetate salt. Grades: 95%. | |
| D-Cys(7)-Octreotide | D-Cys(7)-Octreotide is an impurity of Octreotide, which is a synthetic long-acting cyclic octapeptide used as a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Alternative Names: DPhe-Cys-Phe-DTrp-Lys-Thr-DCys-Thr-ol(Cys2&Cys7 bridge); [7-D-cysteine]octreotide; Octreotide EP Impurity B; [D-Cys7]-Octreotide; D-Phenylalanyl-L-cystyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-D-cystyl-L-threoninol (Disulfide Bridge between Cys2-Cys7); H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-D-Cys-Thr-ol (Disulfide bridge: Cys2-Cys7); D-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, cyclic (2→7)-disulfide; DPhe-CF-DTrp-KT-DCys-Thr-ol(Cys2&Cys7 bridge). Grades: 98%. CAS No. 1211530-36-7. Molecular formula: C49H66N10O10S2. Mole weight: 1019.25. | |
| Deacetylasperulosidic acid | Deacetylasperulosidic acid is a natural compound found in Morinda citrifolia fruit with antioxidant activity. Deacetylasperulosidic acid inhibited the reduction of ear swelling, and also cancelled the suppression of IL-2 production along with the activation of natural killer cells in the same manner as that of Noni-ext. Alternative Names: (1S,4aS,5S,7aS)-1-(β-D-Glucopyranosyloxy)-1,4a,5,7a-tetrahydro-5-hydroxy-7-(hydroxymethyl)cyclopenta[c]pyran-4-carboxylic acid. Grades: >98%. CAS No. 14259-55-3. Molecular formula: C16H22O11. Mole weight: 390.34. | |
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