BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Isorhamnetin 3-O-glucoside | Isorhamnetin-3-O-beta-D-Glucoside is a glycosyloxyflavone found in many vegetables. Uses: For the prevention and/or treatment of diabetes and its complications. Alternative Names: 3-(β-D-Glucopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one; Flavone, 3,4',5,7-tetrahydroxy-3'-methoxy-, 3-β-D-glucopyranoside; Isorhamnetin 3-glucoside; 3,4',5,7-Tetrahydroxy-3'-methoxyflavone 3-β-D-glucopyranoside; 3,5,7,4'-Tetrahydroxy-3'-methoxyflavone 3-β-D-glucoside; 3'-O-Methylquercetin 3-glucoside; 5,7,4'-Trihydroxy-3'-methoxyflavone 3-O-β-glucopyranoside; Isorhamnetin 3-D-glucoside; Isorhamnetin 3-O-β-D-glucopyranoside; Isorhamnetin 3-O-β-D-glucoside; Isorhamnetin 3-O-β-glucoside; Isorhamnetin 3-β-D-glucopyranoside; Isorhamnetin 3-β-D-glucoside. Grades: 97%. CAS No. 5041-82-7. Molecular formula: C22H22O12. Mole weight: 478.40. |  |
| Isorhapontigenin | Isorhapontigenin isolated from the herbs of Gnetum montanum Markgr. Uses: Antioxidant. Alternative Names: (E)-3,4',5-Trihydroxy-3'-methoxystilbene; 5-[(E)-2-(4-Hydroxy-3-methoxyphenyl)ethenyl]-1,3-benzenediol. Grades: 0.98. CAS No. 32507-66-7. Molecular formula: C15H14O4. Mole weight: 258.3. | |
| Isorhynchophylline | Rhynchophylline and isorhynchophylline act as noncompetitive antagonists of the NMDA receptor and that this property may contribute to the neuroprotective and anticonvulsant activity of the Uncaira species plant extracts. Rhynchophylline and isorhynchophylline have a non-competitive antagonistic effect on the NMDA-type ionotropic glutamate receptors, the present results suggest that these alkaloids exert their protective action against ischemia-induced neuronal damage by preventing NMDA, muscarinic M1, and 5-HT2 receptors-mediated neurotoxicity during ischemia. Alternative Names: methyl (E)-2-((3S,6'R,7'S,8a'S)-6'-ethyl-2-oxo-2',3',6',7',8',8a'-hexahydro-5'H-spiro[indoline-3,1'-indolizin]-7'-yl)-3-methoxyacrylate; Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1'S,6'R,7'S,8'aS)-; 7-Isorhyncophylline; Corynoxan-16-carboxylic acid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (16E,20α)-; (+)-Isorhynchophylline; Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, [1'S-[1'α,6'α,7'β(E),8'aα]]-. Grades: >98%. CAS No. 6859-1-4. Molecular formula: C22H28N2O4. Mole weight: 384.47. | |
| Isosalvipuberulin | Isosalvipuberulin can be isolated from the aerial parts of Salvia dugesii. Alternative Names: Isopuberulin. Grades: >98%. CAS No. 115321-32-9. Molecular formula: C20H14O5. Mole weight: 334.3. | |
| Isosativan | Isosativan is a natural flavanone isolated from the herbs of Trifolium pratense L. Alternative Names: 7-O-Methylvestitol. Grades: >95%. CAS No. 60102-29-6. Molecular formula: C17H18O4. Mole weight: 286.3. | |
| Isoscoparin | Isoscoparin is a compound of the flavonoid class found in the seeds of Alliaria petiolata with antioxidant activity. Isoscoparin is promisingly used in the treatment of obesity for its anti-adipogenic property. Alternative Names: C-Glucosyl-6 chrysoeriol; Chrysoeriol 6-C-glucoside; Isoscoparine; (1S)-1,5-anhydro-1-[5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-oxo-4H-chromen-6-yl]-D-glucitol. Grades: >98%. CAS No. 20013-23-4. Molecular formula: C22H22O11. Mole weight: 462.407. | |
| Isosilybin A | Isosilybin A is a flavonoid found in Silybum marianum. Isosilybin A has been identified as the first flavonolignan PPAR-gamma agonist. Alternative Names: Isosilibinin A; (+)-Isosilybin A; Silybin b2. Grades: > 95%. CAS No. 142796-21-2. Molecular formula: C25H22O10. Mole weight: 482.44. | |
| Isosilybin B | Isosilybin B is found in Silybum marianum, it has anti-prostate cancer (PCA) activity that is mediated via cell cycle arrest and apoptosis induction. Alternative Names: Isosilibinin B; (-)-Isosilybin B; Silybin a2. Grades: > 95%. CAS No. 142796-22-3. Molecular formula: C25H22O10. Mole weight: 482.44. | |
| Isosteviol | Isosteviol is a tetracyclic diterpenoid with a beyerane core. It can exhibit antihypertensive activity, reduce blood glucose, suppress cancer cells. Alternative Names: (-)-Isosteviol; iso-Steviol. Grades: >98%. CAS No. 27975-19-5. Molecular formula: C20H30O3. Mole weight: 318.45. | |
| Isotaxiresinol | Isotaxiresinol is a natural lignan found in the branch of Taxus wallichiana. Isotaxiresinol is useful for the treatment of postmenopausal osteoporosis, especially for prevention of bone fracture induced by estrogen deficiency. Uses: Anti-cancer; anti-osteoporosis. Alternative Names: Methyl 3-bromo-2-thiophenecarboxylate. Grades: >95%. CAS No. 26194-57-0. Molecular formula: C19H22O6. Mole weight: 346.38. | |
| ISOTETRANDRINE | Isotetrandrine is isolated from the roots of Stephania tetrandra S.Moore. Uses: Antineoplastic; anti-inflammatory; antihypertensive; antibacterial. Alternative Names: (R,S)-Tetrandrine; O-Methylberbamine; O,O'-Dimethylstepholine; 6,6',7,12-tetramethoxy-2,2'-dimethyl-berbama. Grades: 97%. CAS No. 477-57-6. Molecular formula: C38H42N2O6. Mole weight: 622.8. | |
| Isotetrandrine N-2'-oxide | Isotetrandrine N-2'-oxide is isolated from the roots of Stephania tetrandra S.Moore. Alternative Names: Isotetrandrine N2'-oxide. Grades: 95%. CAS No. 70191-83-2. Molecular formula: C38H42N2O7. Mole weight: 638.8. | |
| Isothymusin | Isothymusin is isolated from the herbs of Limnophila geoffrayi. It exhibits inhibitory activity against Mycobacterium tuberculosis. Uses: Antioxidant activity; antimycobacterial. Alternative Names: 5,8-Dihydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-4H-1-benzopyran-4-one. Grades: 98.5%. CAS No. 98755-25-0. Molecular formula: C17H14O7. Mole weight: 330.3. | |
| Isoverticine | Isoverticine is found in Fritillaria monantha. Alternative Names: Isopeimine; 6-Epiverticine; Dihydroverticinone; 17-Epidihydroimperialine. Grades: > 95%. CAS No. 23496-43-7. Molecular formula: C27H45NO3. Mole weight: 431.65. | |
| Ispinesib | Ispinesib is a synthetic small molecule, derived from quinazolinone, with antineoplastic properties. Ispinesib selectively inhibits the mitotic motor protein, kinesin spindle protein (KSP), resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and cell death in tumor cells that are actively dividing. Because KSP is not involved in nonmitotic processes, such as neuronal transport, ispinesib may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents. Alternative Names: SB-715992; SB715992; SB 715992; CK 0238273; CK-0238273; CK0238273. CAS No. 336113-53-2. Molecular formula: C30H33ClN4O2. Mole weight: 517.07. | |
| Isradipine | Isradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure. Alternative Names: DynaCirc; Prescal; Lomir; PN-200-110; PN-205-033; PN-205-034; 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3-methyl 5-(1-methylethyl) ester. Grades: >98%. CAS No. 75695-93-1. Molecular formula: C19H21N3O5. Mole weight: 371.39. | |
| Istradefylline | Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist (Ki=2.2 nM). Uses: Adenosine a2 receptor antagonists. Alternative Names: KW6002; KW 6002; KW-6002; Istradefylline. 8-[(1E)-2-(2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione. Grades: > 95%. CAS No. 155270-99-8. Molecular formula: C20H24N4O4. Mole weight: 384.43. | |
| IT 901 | IT 901, a bioactive naphthalenethiobarbiturate derivative, potently inhibits the NF-κB subunit c-Rel with IC50 value of 3 μM. It shows its anticancer properties in Hematologic Malignancies by inhibiting the oxidative stress response in lymphoma cells. It suppressed graft-versus-host disease while preserving graft-versus-lymphoma activity during allogeneic transplantation. It did not elicit increased levels of reactive oxygen species in normal leukocytes, illustrating its cancer selective properties. It is used for the treatment of human B-cell lymphoma and reveals antitumor properties in vitro and in vivo. It is also a novel therapeutic agent to ameliorate graft-versus-host disease. Alternative Names: IT-901; IT 901; IT901; 5-[(2,4-Dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione. Grades: ≥98% by HPLC. CAS No. 1584121-99-2. Molecular formula: C17H14N2O4S. Mole weight: 342.37. | |
| Itacitinib | Itacitinib is a potent and selective JAK1 inhibitor developed for the treatment of Graft-versus-host disease and non-small cell lung cancer. Alternative Names: INCB 039110; 2-[1-[1-[3-fluoro-2-(trifluoromethyl)pyridine-4-carbonyl]piperidin-4-yl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile. Grades: >98%. CAS No. 1334298-90-6. Molecular formula: C26H23F4N9O. Mole weight: 553.51. | |
| Itol A | Itol A is a natural diterpenoid found in the herbs of Geranium wilfordii. Alternative Names: 20-Deoxyitol B. Grades: >98%. CAS No. 1033747-78-2. Molecular formula: C20H32O6. Mole weight: 368.5. | |
| Ivabradine Impurity 15 | An impurity of Ivabradine, which is a novel heart rate lowering medication. It can slow the heart rate by hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blockers. Ivabradine is marketed under trade names including Coralan, Corlentor, Procoralan, Coraxan. Alternative Names: 3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-4,5-dihydro-7,8-dimethoxy-1H-3-benzazepine-1,2(3H)-dione; 2-Oxo-ivabradine Hydrochloride. Grades: 95%. CAS No. 1616710-50-9. Molecular formula: C27H35ClN2O6. Mole weight: 519.03. | |
| ivDde-Lys-OH | ivDde-Lys-OH. | |
| Ivosidenib | Ivosidenib is an oral inhibitor that specifically inhibits a mutated form of IDH1 in the cytoplasm, which blocks the proliferation of tumor cells expressing IDH1. Alternative Names: AG-120; AG 120; AG120; (2S)-N-[(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl]-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide; Glycinamide, N2-[1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl]-2-(2-chlorophenyl)-N1-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-; TIBSOVO; (S)-N-((S)-1-(2-Chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide. CAS No. 1448347-49-6. Molecular formula: C28H22ClF3N6O3. Mole weight: 582.96. | |
| Ixabepilone | Ixabepilone (also known as azaepothilone B, or BMS-247550) is an orally bioavailable microtubule inhibitor. Ixabepilone was a semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Ixabepilone was approved in 2007. Alternative Names: Azaepothilone B; BMS247550; BMS-247550; BMS 247550; Ixempra. Grades: >98%. CAS No. 219989-84-1. Molecular formula: C27H42N2O5S. Mole weight: 506.7. | |
| J 147 | J 147, under the IUPAC name N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]acetamide, is a phenyl hydrazide compound that has been shown to prevent memory deficits in an Alzheimer's disease mouse model. in vitro: A potent neuroprotective and neurotrophic compound (EC50 = 25 - 200 nM) in vivo: Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus. Uses: Implicated in alzheimer's disease. Alternative Names: J147; J 147; J-147. N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]acetamide; J-147; 1146963-51-0; N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N'-(3-methoxybenzylidene)acetohydrazide; CHEMBL2387144; SCHEMBL12995834; 3752AH; AKOS024458485; CS-3688; AK279964; BC600735; HY-13779; 2,2,2-Trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl) methylene]hydrazide; J 147|2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide. CAS No. 1146963-51-0. Molecular formula: C18H17F3N2O2. Mole weight: 350.33. | |
| Jaceosidin | Jaceosidin is a natural flavonoid isolated from the herbs of Artemisia arctica. Jaceosidin exhibits the activities of anti-oxidative, anti-inflammatory and anti-neuroinflammation. Uses: Anti-oxidative, anti-inflammatory, anti-neuroinflammation. Alternative Names: 5,7-dihydroxy-2-(4-hydroxy-3-methoxy-phenyl)-6-methoxy-chromen-4-one. Grades: >98%. CAS No. 18085-97-7. Molecular formula: C17H14O7. Mole weight: 330.29. | |
| JANEX-1 | A cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3; IC50=78 μM). Has no effect on JAK1, JAK2, or Zap/Syk or Src tyrosine kinases. Acts as a potent inhibitor of glioblastoma cell adhesion and migration. Also reported to block thrombin-induced platelet aggregation. Alternative Names: WHI-P131, WHI P-131, WHI P131, Janex 1. Grades: >98%. CAS No. 202475-60-3. Molecular formula: C16H15N3O3. Mole weight: 297.31. | |
| Jasminin | Jasminin is extracted from the leaves of Jasminum primulinum HEMSL. It tastes bitter. Alternative Names: 4-Ethylidene-3-(β-D-glucopyranosyloxy)-3,4,4a,5,9,10,11,12-octahydro-10-(2-hydroxy-1-methylethyl)-15-methyl-9,12-methano-6H,8H,14H-pyrano[3,4-c][1,7]dioxacyclododecin-6,14-dione. Grades: 98.5%. CAS No. 30164-93-3. Molecular formula: C26H38O12. Mole weight: 542.57. | |
| Jatrophane 2 | Jatrophane 2 can be found in the branches of Jatropha carcas L. Alternative Names: 2,5,7,8,9,14-Hexaacetoxy-3-benzoyloxy-15-hydroxyjatropha-6(17),11E-diene. Grades: >98%. CAS No. 210108-86-4. Molecular formula: C39H50O15. Mole weight: 758.8. | |
| Jatrophane 3 | Jatrophane 3 can be found in the branches of Jatropha carcas L. Alternative Names: 2,5,14-Triacetoxy-3-benzoyloxy-8,15-dihydroxy-7-isobutyroyloxy-9-nicotinoyloxyjatropha-6(17),11E-diene. Grades: >98%. CAS No. 210108-87-5. Molecular formula: C43H53NO14. Mole weight: 807.9. | |
| Jatrophane 4 | Jatrophane 4 comes from the branches of Jatropha carcas L. Alternative Names: 2,5,9,14-Tetraacetoxy-3-benzoyloxy-8,15-dihydroxy-7-isobutyroyloxyjatropha-6(17),11E-diene. Grades: 95%. CAS No. 210108-88-6. Molecular formula: C39H52O14. Mole weight: 744.8. | |
| Jatrophane 5 | Jatrophane 5, coming from the branches of Jatropha carcas L, demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR). Alternative Names: 2,5,7,14-Tetraacetoxy-3-benzoyloxy-8,15-dihydroxy-9-nicotinoyloxyjatropha-6(17),11E-diene. Grades: >98%. CAS No. 210108-89-7. Molecular formula: C41H49NO14. Mole weight: 779.8. | |
| Jatrorrhizine hydrochloride | Jatrorrhizine Hydrochloride (JH), an active component of the traditional Chinese medicinal herb Coptis chinensis, inhibited the proliferation and neovascularization of C8161 human metastatic melanoma cells. The effective inhibitory effects of Jatrorrhizine Hydrochloride on metastatic melanoma cell proliferation and neovascularization with low toxicity suggest that Jatrorrhizine Hydrochloride is a potential new antimelanoma drug candidate. Alternative Names: Dibenzo[a,g]quinolizinium, 5,6-dihydro-3-hydroxy-2,9,10-trimethoxy-, chloride (1:1); Berbinium, 7,8,13,13a-tetradehydro-3-hydroxy-2,9,10-trimethoxy-, chloride; Dibenzo[a,g]quinolizinium, 5,6-dihydro-3-hydroxy-2,9,10-trimethoxy-, monochloride; Jatrorrhizine chloride; Neprotine chloride; NSC 645313. Grades: >98%. CAS No. 6681-15-8. Molecular formula: C20H20ClNO4. Mole weight: 373.83. | |
| JD-5037 | Jd-5037 is a peripherally-restricted cannabinoid inverse agonist at CB1 receptors that can be used as an anti-obesity drug, with a 700-fold higher affinity compared to CB2 receptors. Alternative Names: JD 5037; JD5037; (S)-2-(((E)-((S)-3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl)((4-chlorophenyl)sulfonamido)methylene)amino)-3-methylbutanamide. Grades: >98%. CAS No. 1392116-14-1. Molecular formula: C27H27Cl2N5O3S. Mole weight: 572.5. | |
| Jervine | Jervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling. It is an inhibitor of Smo and derived from the Veratrum plant species. Jervine can be used to induce abnormal morphogenesis in a number of experimental models. Uses: Antibacterial. Alternative Names: Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one, 2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-, (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-; (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-Hexadecahydro-3-hydroxy-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one; Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3β,23β)-; Jervin; NSC 23898; NSC 7520; Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one, 2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-, [3S-(3α,6aα,6bβ,9α(3'S*,3'aR*,6'R*,7'aS*),11aβ,11bα)]-. Grades: >98%. CAS No. 469-59-0. Molecular formula: C27H39NO3. Mole weight: 425.60. | |
| JHU37160 | JHU37160 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist. It has high affinity in vitro for hM3Dq and hM4Di (Ki values are 1.9 nM (hM3Dq) and 3.6 nM (hM4Di). Alternative Names: JHU 37160; JHU-37160. CAS No. 2369979-68-8. Molecular formula: C19H20ClFN4. Mole weight: 358.84. | |
| Jinflexin A | Jinflexin A is a remarkable and potent pharmacological natural compound, finding extensive application for studying various ailments such as rheumatoid arthritis, osteoarthritis and diverse inflammatory joint disorders. This multifaceted natural compound exerts its mechanism of action via the proficient inhibition of pro-inflammatory cytokine production. Grades: 96.0%. CAS No. 2055155-75-2. Molecular formula: C19H22O3. Mole weight: 298.382. | |
| JK-184 | JK-184 is a potent downstream hedgehog (Hh) signaling antagonist that functions by alcohol dehydrogenase 7 (Adh7) inhibition, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). Hedgehog signaling plays a key role in a wide variety of developmental processes as well as cancer progression. JK-184 exhibits antiproliferative activity. Uses: Differentiation. Alternative Names: JK184; JK 184. Grades: 98%. CAS No. 315703-52-7. Molecular formula: C19H18N4OS. Mole weight: 350.44. | |
| JK-P3 | JK-P3 is a VEGFR2 inhibitor with IC50 values of 7.8 μM. JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but exhibits no effect on FGFR signaling in cell-based assays. It suppresses wound healing and tube formation in HUVEC without effecting endothelial cell proliferation. Alternative Names: 3,4-dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)benzamide. CAS No. 942655-44-9. Molecular formula: C18H17N3O3. Mole weight: 323.352. | |
| JNJ 0966 | JNJ 0966 is a selective inhibitor of MMP-9 (IC50 = 440 nM) with no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity. JNJ 0966 was indicated to alleviate the pain of experimental autoimmune encephalomyelitis in a mouse model. Alternative Names: JNJ-0966; JNJ0966; N-[2-[(2-Methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]acetamide. Grades: ≥98% by HPLC. CAS No. 315705-75-0. Molecular formula: C16H16N4O2S2. Mole weight: 360.45. | |
| JNJ-10191584 | JNJ-10191584 is a selective histamine H4 receptor antagonist. It inhibits mast cell in vitro with IC50 value of 138nM. JNJ-10191584 has antiinflammatory and analgesic effects in animal studies of acute inflammation. No development was reported for the treatment of Allergic rhinitis, Atopic dermatitis, Pruritus and Respiratory tract disorders. Uses: Allergic rhinitis; atopic dermatitis; pruritus; respiratory tract disorders. Alternative Names: JNJ-10191584; JNJ10191584; JNJ 10191584; VUF-6002; VUF 6002; VUF6002; (5-Chloro-1H-benzimidazol-2-yl)(4-methylpiperazin-1-yl)methanone;869497-75-6(maleate). Grades: 98%. CAS No. 73903-17-0. Molecular formula: C13H15ClN4O. Mole weight: 278.74. | |
| JNJ-26483327 | JNJ-26483327 is an orally bioavailable, small-molecule, multitargeted reversible tyrosine kinase inhibitor with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor JNJ-26483327 binds to and inhibits several members of the epidermal growth factor receptor (EGFR) family, including EGFR, HER2 and HER4; Src family kinases (Lyn, Yes, Fyn, Lck and Src); and vascular endothelial growth factor receptor type 3 (VEGFR3). By inhibiting several different signaling molecules that play crucial roles at various stages in tumorigenesis, this agent may inhibit tumor growth, invasion, migration and metastasis. In addition, JNJ-26483327 crosses the blood-brain barrier (BBB). Alternative Names: JNJ-26483327; JNJ 26483327; JNJ26483327. CAS No. 807640-87-5. Molecular formula: C22H25BrN4O2. Mole weight: 457.372. | |
| JNJ 303 | JNJ 303 has been found to be a potent IKs blocker (IC50 = 64 nM) as well as a 11β-HSD1 inhibitor. Alternative Names: JNJ303; JNJ-303; JNJ 303; AC-1; AC 1; AC1; 2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3.3.1.13,7]dec-2-yl]-propanamide. Grades: ≥98% by HPLC. CAS No. 878489-28-2. Molecular formula: C21H29ClN2O4S. Mole weight: 440.98. | |
| JNJ-40411813 | JNJ-40411813 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM. Alternative Names: JNJ-40411813; JNJ 40411813; JNJ40411813; ADX71149; ADX 71149; ADX-71149. Grades: >98%. CAS No. 1127498-03-6. Molecular formula: C20H25ClN2O. Mole weight: 344.88. | |
| JNJ 63533054 | JNJ 63533054 is a potent and selective GPR139 agonist (EC50 = 16 nM) that is brain and cell penetrant. JNJ 63533054 is selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142. Alternative Names: GTPL8766; GTPL 8766; GTPL-8766; JNJ63533054; JNJ-63533054. Grades: 98%. CAS No. 1802326-66-4. Molecular formula: C17H17ClN2O2. Mole weight: 316.78. | |
| JNK-IN-8 | JNK-IN-8 inhibits c-Jun phosphorylation in HeLa and A375 cells with EC50 of 486 nM and 338 nM, respectively. Uses: Protein kinase inhibitors. Alternative Names: JNK-IN-8; JNK-IN 8; JNK-IN8; JNK Inhibitor XVI; c-Jun N-terminal Kinase Inhibitor XVI. Grades: >98%. CAS No. 1410880-22-6. Molecular formula: C29H29N7O2. Mole weight: 507.59. | |
| (+)-JQ-1 | (+)-JQ-1 is a potent and selective BET bromodomain inhibitor, IC50 values are 77 nM and 33 nM for inhibiting BRD4 (N-terminal) and BRD4 (C-terminal), respectively. Alternative Names: JQ1. CAS No. 1268524-70-4. Molecular formula: C23H25ClN4O2S. Mole weight: 456.99. | |
| (+)-JQ1 carboxylic acid | (+)-JQ1 carboxylic acid is the carboxylic acid form of BET bromodomain inhibitor (+)-JQ1. Alternative Names: JQ-1 carboxylic acid; (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetic acid. Grades: ≥98%. CAS No. 202592-23-2. Molecular formula: C19H17ClN4O2S. Mole weight: 400.881. | |
| JTE-013 | JTE-013 is a potent and selective sphingosine-1-phosphate (S1P) receptor 2 (S1P2) antagonist (IC50=17.6 nM). Alternative Names: 1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea; JTE-013; JTE 013; JTE013. Grades: >98%. CAS No. 383150-41-2. Molecular formula: C17H19Cl2N7O. Mole weight: 408.287. | |
| Juncuenin D | Juncuenin D, an all-natural compound, boasts of its potent anti-inflammatory and anticancer properties. Research studies exhibit its capability to suppress leukemia cells' growth via selective cell cycle arrest. Furthermore, it showcases its therapeutic potential in terms of inflammatory diseases by impeding pro-inflammatory cytokine production. Its revolutionary features highlight its significance as a potential therapeutic agent with immense curative measures. Alternative Names: Juncuenin D; 1161681-24-8; SCHEMBL23764926; HY-N8464; AKOS040762871; CS-0144572; F94140. Grades: 97.5%. CAS No. 1161681-24-8. Molecular formula: C18H18O3. Mole weight: 282.339. | |
| Juncusol | Juncusol is a 9,10-dihydrophrenathrene found in Juncus species with antimicrobial activity against Bacillus subtilis and Staphylococcus aureus. Alternative Names: 1,6-dimethyl-5-vinyl-9,10-dihydrophenanthrene-2,7-diol; 5-ethenyl-1,6-dimethyl-9,10-dihydrophenanthrene-2,7-diol. Grades: >98%. CAS No. 62023-90-9. Molecular formula: C18H18O2. Mole weight: 266.34. | |
| Juncutol | Juncutol, a topical antiseptic, exerts its antimicrobial effect through the active ingredient, povidone-iodine, which eradicates bacteria and other microorganisms that may cause infections in cuts, wounds, and burns. In addition to this primary indication, it has been employed for the management of chronic wounds, including diabetic foot ulcers. With its proven efficacy and safety profile, Juncutol is an indispensable tool in wound care. Alternative Names: Juncutol; 1021950-14-0; AKOS040762876; HY-133098; CS-0110687; F94141. Grades: 98.0%. CAS No. 1021950-14-0. Molecular formula: C18H18O2. Mole weight: 266.34. | |
| JX 06 | JX 06 is a potent, selective and covalent pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor with IC50 values of 49, 101 and 313 nM for PDK1, PDK2 and PDK3, respectively. It suppresses A549 lung cancer cell proliferation in vitro and reduces tumor volume of A549 xenografts in mice. Alternative Names: JX-06; JX06; Bis(morpholinothiocarbonyl) Disulfide; 4,4'-(Dithiodicarbonothioyl)bis[morpholine]; 4-Morpholinethiocarbonyl Disulfide; Dimorpholinethiuram Disulfide; Disulfide, bis(4-Morpholinylthioxomethyl); NSC 402538; bis(Oxydi-2,1-ethanediyl)-thiuram Disulfide. Grades: ≥98% by HPLC. CAS No. 729-46-4. Molecular formula: C10H16N2O2S4. Mole weight: 324.51. | |
| JY-2 | JY-2. CAS No. 339103-05-8. | |
| JZL195 | JZL195 is a potent dual inhibitor of Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), enzymes that degrade the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA), the endogenous ligands for the cannabinoid G-protein coupled receptors CB1 and CB2. IC50 values are 2 nM for MAGL and 4 nM for FAAH. JZL195 has been shown to inhibit endocannabinoid hydrolysis and elevate 2-AG and AEA levels in vivo. Alternative Names: JZL195; JZL-195; JZL 195. Grades: >98%. CAS No. 1210004-12-8. Molecular formula: C24H23N3O5. Mole weight: 433.46. | |
| K03861 | K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely. Alternative Names: AUZ 454; K 03861; K-03861; Urea, N-[4-[(2-amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-; 1-[4-[(2-Amino-4-pyrimidinyl)oxy]phenyl]-3-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]urea. Grades: 98%. CAS No. 853299-07-7. Molecular formula: C24H26F3N7O2. Mole weight: 501.50. | |
| K-7174 dihydrochloride | K-7174, one of proteasome inhibitory homopiperazine derivatives, exhibits a therapeutic effect, which is stronger when administered orally than intravenously, without obvious side effects in a murine myeloma model. Moreover, K-7174 kills bortezomib-resistant myeloma cells carrying a β5-subunit mutation in vivo and primary cells from a patient resistant to bortezomib. Alternative Names: 1,4-bis((E)-5-(3,4,5-trimethoxyphenyl)pent-4-en-1-yl)-1,4-diazepane dihydrochloride; K7174; K 7174; K-7174; K-7174-2HCl; K-7174 dihydrochloride. Grades: >98%. CAS No. 191089-60-8. Molecular formula: C33H50Cl2N2O6. Mole weight: 641.67. | |
| Kaempferitrin | Kaempferitrin isolated from the root of Kaempferia galangal L. It stimulates glucose-metabolizing enzymes and promotes glucose homeostasis. Uses: Cytotoxic and antitumor effects; antidepressant-like effect; immunostimulatory effects. Alternative Names: 3,7-Bis[(6-deoxy-α-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 3,4',5,7-Tetrahydroxyflavone 3,7-dirhamnoside; Grosvenorine II; Kaempferitin; Kaempferol 3,7-bisrhamnoside; Kaempferol 3,7-di-O-rhamnopyranoside; Kaempferol 3,7-di-O-rhamnoside; Kaempferol 3,7-di-O-α-L-rhamnopyranoside; Kaempferol 3,7-di-α-L-rhamnopyranoside; Kaempferol 3,7-di-α-L-rhamnoside; Kaempferol 3,7-dirhamnoside; Kaempferol 3,7-O-α-L-dirhamnoside; Kaempferol 3-O-rhamnoside 7-O-rhamnoside; Kaempferol 3-O-α-L-rhamnopyranoside 7-O-α-L-rhamnopyranoside; Kaempferol-3,7-O-bis-α-L-rhamnopyranoside; Kaempferol-3,7-O-dirhamnose; Kampferol 3,7-di-O-α-L-rhanmopyranoside; Lespedin; Lespenephryl. Grades: >95%. CAS No. 482-38-2. Molecular formula: C27H30O14. Mole weight: 578.52. | |
| Kaempferol-3-O-α-L-rhamnopyranosyl-(1?6)-β-D-glucopyranosyl-(1?2)-β-D-glucopyranoside | Kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside is found in Hosta plantaginea, it shows antioxidant activity. Alternative Names: Kaempferol-3-O-alpha-L-rhamnopyranosyl-(1→6)-beta-D-glucopyranosyl-(1→2)-beta-D-glucopyranoside. Grades: 98%. CAS No. 476617-49-9. Molecular formula: C33H40O20. Mole weight: 756.66. | |
| Kaempferol 3-O-beta-(6''-p-coumaroyl) glucopyranosyl (1?2)-alpha-L-rhamnopyranoside | Kaempferol 3-O-beta-(6''-p-coumaroyl)glucopyranosyl(1→2)-alpha-L-rhamnopyranoside is a flavonoid and a natural antioxidant. Alternative Names: Kaempferol-3-O-(6'''-trans-p-coumaroyl-2''-glucosyl)rhamnoside; 3-O-{2-O-[6-O-(p-Hydroxyl-E-coumaroyl)-glucosyl]-(1-2)rhamnosyl kaempferol. Grades: 95%. CAS No. 111957-48-3. Molecular formula: C36H36O17. Mole weight: 740.66. | |
| Kaempferol 7,4'-dimethyl ether | 3,5-Dihydroxy-4',7-dimethoxyflavone is a natural flavonoid found in the herb of Andrographis paniculata (Burm. f.) Nees. Alternative Names: Kaempferol 4',7-dimethyl ether. Grades: >98%. CAS No. 15486-33-6. Molecular formula: C17H14O6. Mole weight: 314.3. | |
| Kaempferol-7-O-glucoside | Kaempferol-7-O-β-D-glucopyranoside is extracted from the herbs of Hosta plantaginea. Alternative Names: 2-(4-Hydroxyphenyl)-3,5-dihydroxy-7-(β-D-glucopyranosyloxy)-4H-1-benzopyran-4-one; 7-[(β-D-Glucopyranosyl)oxy]-3,4',5-trihydroxyflavone; Kaempferol 7-monoglucoside; 7-(β-D-Glucopyranosyloxy)-3,5-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; Glucosyl-7-kaempferol; Populnin. Grades: >98%. CAS No. 16290-07-6. Molecular formula: C21H20O11. | |
| Kaempferol 7-O-rhamnoside | Kaempferol 7-O-rhamnoside is isolated from the herbs of Maytenus hookeri. Alternative Names: Kaempferol-7-O-alpha-L-rhamnoside. Grades: 0.985. CAS No. 20196-89-8. Molecular formula: C21H20O10. Mole weight: 432.4. | |
| Kaerophyllin | Kaerophyllin isolated from the roots of Bupleurum chinense DC. Alternative Names: (3E,4R)-4-(1,3-benzodioxol-5-ylmethyl)-3-[(3,4-dimethoxyphenyl)methylidene]oxolan-2-one. Grades: > 95%. CAS No. 75590-33-9. Molecular formula: C21H20O6. Mole weight: 368.4. | |
| Kalopanaxsaponin H | Kalopanaxsaponin H is extracted from the herbs of Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. It has antidiabetic activity. Alternative Names: Macranthoside A. Grades: >98%. CAS No. 128730-82-5. Molecular formula: C47H76O17. Mole weight: 913.1. | |
| Kanshone H | Kanshone H can be isolated from the rhizomes and roots of Nardostachys chinensis. Alternative Names: (1aR,7R,7aR,7bS)-1,1,7,7a-tetramethyl-1a,6,7,7b-tetrahydrocyclopropa[a]naphthalen-2-one. Grades: 98.0%. CAS No. 1445952-33-9. Molecular formula: C15H20O. Mole weight: 216.324. | |
| Kansuinine A | Kansuinine A is extracted from the roots of Euphorbia kansui. It shows analgesic props and NGF inducing activity. Alternative Names: Kansuinin A. Grades: 97.5%. CAS No. 57701-86-7. Molecular formula: C37H46O15. Mole weight: 730.76. | |
| Karakoline | Alkaloid , from plants of the Ranunculaceae family. Ganglioblocker; nicotinic receptor antagonist; hypotensive; presents micromolar affinity at brain a Bungarotoxin-sensitive nAChR. (See attached sheet.). Alternative Names: (16S)-20-Ethyl-16-methoxy-4-methylaconitane-1α,8,14α-triol. Grades: 97% (TLC). CAS No. 39089-30-0. Molecular formula: C22H35O4N. Mole weight: 377.52. | |
| Karavilagenin F | Karavilagenin F is a natural triterpenoids compound. Grades: 98%. CAS No. 1639024-15-9. Molecular formula: C31H50O5. Mole weight: 502.73. | |
| Kazinol B | Kazinol B is a natural flavonoid found in the barks of Broussonetia papyrife. It has inhibition of nitric oxide production on LPS-activated macrophages and has inhibiion of SOCE. Alternative Names: (2S)-2',2'-dimethyl-7'-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H,2'H-2,6'-bichrom ene-7,8'-diol. Grades: >98%. CAS No. 99624-27-8. Molecular formula: C25H28O4. Mole weight: 392.5. | |
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