BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Kazinol U | Kazinol U is one estrogenic found in Broussonetia kazinoki. Kazinoki may be useful in the treatment of menopausal symptoms and may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes. Alternative Names: 4-[(2R)-3,4-Dihydro-7-hydroxy-2H-1-benzopyran-2-yl]-3-(3-methyl-2-buten-1-yl)-1,2-benzenediol. Grades: >96%. CAS No. 1238116-48-7. Molecular formula: C20H22O4. Mole weight: 326.39. |  |
| KB-R7943 mesylate | KB-R7943 is a potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = 0.7 μM). Alternative Names: KB-R7943 (mesylate); 4-((4-Nitrobenzyl)oxy)phenethyl carbamimidothioate methanesulfonate; Carbamimidothioic acid, 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester, methanesulfonate (1:1). Grades: 98%. CAS No. 182004-65-5. Molecular formula: C17H21N3O6S2. Mole weight: 427.49. | |
| KD025 | KD025 is an orally available and selective ROCK2 inhibitor with IC50 value of 60 nM and Ki value of 41 nm, respectively. It was shown to suppress adipogenesis in human adipose-derived stem cells. Uses: Protein kinase inhibitors. Alternative Names: SLx 2119; SLx2119; KD-025; 2-[3-[4-(1H-indazol-5-ylamino)quinazolin-2-yl]phenoxy]-N-propan-2-ylacetamide. Grades: >98%. CAS No. 911417-87-3. Molecular formula: C26H24N6O2. Mole weight: 452.51. | |
| KDM5-inhibitor | KDM5-inhibitor is an analog of CPI-455, a selective KDM5 inhibitor. CPI-455 increases levels of H3K4 trimethylation (H3K4me3) and decreases the number of DTPs in multiple cancer cell lines treated with standard chemotherapy or targeted agents. It reduces survival of drug-tolerant cancer cells. Alternative Names: KDM5 inhibitor; 7-oxo-5-phenyl-6-propyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile. Molecular formula: C16H14N4O. Mole weight: 278.315. | |
| Kerosene | KEROSENE is a complex combination of normal paraffins obtained by a selective adsorption process using a solid adsorbent such as a molecular sieve. It consists of straight chain saturated hydrocarbons having carbon numbers predominantly in the range of C5 through C20 and boiling in the range of 35.degree.C to 345.degree.C (95.degree.F to 653.degree.F). Alternative Names: paraffins(petroleum),normalc5-20;Paraffins,petroleum,normalC5-20;KEROSENE WHITE;KEROSENE;KEROSINE;normal(C10+);C9-C17 range;n-Paraffins. CAS No. 64771-72-8. | |
| (±)-Ketoconazole-[d4] | (±)-Ketoconazole-[d4] (cis-isomers) is the labelled analogue of (±)-Ketoconazole, which is a synthetic imidazole antifungal drug used to treat fungal infections. Alternative Names: (+/-)-Ketoconazole-d4 (piperazine-3,3,5,5-d4) (cis-isomers); (±)-Ketoconazole-d4; cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine-d4. Grades: 95% by HPLC; 98% atom D. CAS No. 1398065-75-2. Molecular formula: C26H24D4Cl2N4O4. Mole weight: 535.46. | |
| Ketotifen Fumarate | Ketotifen is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer. It is most commonly sold as a salt with fumaric acid, ketotifen fumarate, and is available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis,or the itchy red eyes caused by allergies. In its oral form, it is used to preventasthma attacks. Uses: Antipruritics. Alternative Names: Zaditen; Zaditor. Grades: >98%. CAS No. 34580-14-8. Molecular formula: C19H19NOS.C4H4O4. Mole weight: 425.5. | |
| KGA2727 | KGA2727 is a selective and potent SGLT1 inhibitor for the treatment of diabete. Its inhibition constant (Ki) values of 97 and 13,600 nM for human (h) SGLT1 and hSGLT2 respectively. It inhibited the absorption of glucose but not that of fructose. Uses: Kga2727 is used for the treatment of diabete. Alternative Names: KGA-2727; KGA 2727; 3-(3-{4-[3-(beta-D-glucopyranosyloxy)-5-isopropyl-1Hpyrazol-4-ylmethyl]-3-methylphenoxy}propylamino)propionamide. Grades: 98%. CAS No. 666842-36-0. Molecular formula: C26H40N4O8. Mole weight: 536.63. | |
| Kimcuongin | Kimcuongin is a coumarin isolated from Murraya paniculata leaves that has the potential to be used as a vasodilator. Alternative Names: [1-(7-methoxy-2-oxochromen-8-yl)-3-methyl-1-oxobut-2-en-2-yl] 3-methylbut-2-enoate. Grades: 98.5%. CAS No. 1872403-23-0. Molecular formula: C20H20O6. Mole weight: 356.374. | |
| KNK437 | KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40. Alternative Names: KNK437; KNK-437; KNK 437. Grades: 98%. CAS No. 218924-25-5. Molecular formula: C13H11NO4. Mole weight: 245.23. | |
| Kongensin A | Kongensin A is isolated from the herbs of Croton cascarilloides. Alternative Names: HY-N3417. Grades: 98%. CAS No. 885315-96-8. Molecular formula: C22H30O5. Mole weight: 374.5. | |
| Koumine | Koumine has a significant analgesic effect in rodent behavioral models of inflammatory and neuropathic pain, and that the reduction in neuropathic pain may be associated with the upregulation of allopregnanolone in the spinal cord. Koumine has the potential to be a future breast cancer chemotherapeutic agent. Uses: Antineoplastic. Alternative Names: (3R,7alpha,20alpha)-1,2,18,19-Tetradehydro-3,17-epoxy-7,20(2H,19H)cyclovobasan; 7,20(2H,19H)-Cyclovobasan, 1,2,18,19-tetradehydro-3,17-epoxy-, (3R,7alpha,20alpha)-. Grades: >98%. CAS No. 1358-76-5. Molecular formula: C20H22N2O. Mole weight: 306.4. | |
| Koumine N-oxide | Koumine N-oxide is an alkaloid compound found in the herbs of Gelsemium elegans. Alternative Names: Koumine N-oxide;6,4-(Epoxymethano)-3,11b-methano-11bH-pyrido[4,3-c]carbazole, 11c-ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-, 2-oxide, (3S,4S,4aR,6R,11bS,11cS)-. Grades: >96%. CAS No. 113900-75-7. Molecular formula: C20H22N2O2. Mole weight: 322.4. | |
| KR-12 TFA | KR-12 is an antibacterial peptide. It has activity against gram-positive bacteria and gram-negative bacteria. Alternative Names: KR-12 (human) TFA; Antibacterial Protein LL-37 amide (human) (18-29) TFA. Grades: 98%. Molecular formula: C73H128F3N25O17. Mole weight: 1684.97. | |
| KU-60019 | KU-60019 is a potent and selective ATM inhibitor. KU-60019 is 10-fold more effective than KU-55933 at blocking radiation-induced phosphorylation of key ATM targets in human glioma cells. As expected, KU-60019 is a highly effective radiosensitizer of human glioma cells. KU-60019 inhibits the DNA damage response, reduces AKT phosphorylation and prosurvival signaling, inhibits migration and invasion, and effectively radiosensitizes human glioma cells. Alternative Names: KU60019; KU 60019; 2-((2R,6S)-2,6-dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide. Grades: 98%. CAS No. 925701-49-1. Molecular formula: C30H33N3O5S. Mole weight: 547.67. | |
| Kukoamine A | Kukoamine A is a spermine alkaloid isolated from Lycium chinense, potatoes, and tomatoes. It exhibits diverse biological activities, including anticancer, neuroprotective, and anti-inflammatory properties. Kukoamine A inhibits human glioblastoma cell growth and migration via apoptosis induction and epithelial-mesenchymal transition attenuation mediated by downregulating expressions of 5-LOX and C/EBPβ. Alternative Names: N1,N2-bis(dihydrocaffeoyl)spermine; 1,14-Bis(dihydrocaffeoyl)spermidine; N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxy-benzenepropanamide]. Grades: ≥95%. CAS No. 75288-96-9. Molecular formula: C28H42N4O6. Mole weight: 530.66. | |
| Kukoamine A-[d8] DiHCl | Kukoamine A-[d8] DiHCl. | |
| Kushenol A | Kushenol A isolated from the roots of Sophora flavescens Ait. It shows selective alpha-glucosidase inhibitory activity. Alternative Names: Leachianone E. Grades: > 95%. CAS No. 99217-63-7. Molecular formula: C25H28O5. Mole weight: 408.5. | |
| Kushenol X | Kushenol X isolated from the roots of Sophora flavescens Ait. Uses: Antibacterial; antiandrogen. Alternative Names: (2R,3R)-2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-8-(2-isopropenyl-5-methyl-4-hexen-1-yl)-2,3-dihydro-4H-chromen-4-one. Grades: 0.98. CAS No. 254886-77-6. Molecular formula: C25H28O7. Mole weight: 440.5. | |
| Kuwanon E | Kuwanon E is a flavonoid compound found in the root bark of Morus alba L. Alternative Names: (S)-2-[5-[(E)-3,7-Dimethyl-2,6-octadienyl]-2,4-dihydroxyphenyl]-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one;5'-[(E)-3,7-Dimethyl-2,6-octadienyl]-2',4',5,7-tetrahydroxyflavanone. Grades: >98%. CAS No. 68401-05-8. Molecular formula: C25H28O6. Mole weight: 424.5. | |
| KW-2449 | KW-2449 is a novel multikinase inhibitor, which suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Recent research showed that HDACIs increase KW-2449 lethality in Bcr/Abl(+) cells in association with inhibition of Bcr/Abl, generation of ROS, and induction of DNA damage. This strategy preferentially targets primary Bcr/Abl(+) hematopoietic cells and exhibits enhanced in vivo activity. Combining KW-2449 with HDACIs warrants attention in IM-resistant Bcr/Abl(+) leukemias. Alternative Names: KW2449; KW-2449; KW 2449. CAS No. 1000669-72-6. Molecular formula: C20H20N4O. Mole weight: 332.407. | |
| KX2-391 | KX2-391 is an orally bioavailable small molecule Src kinase inhibitor with potential antineoplastic activity. Unlike other Src kinase inhibitors which bind to the ATP-binding site, Src kinase inhibitor KX2-391 specifically binds to the peptide substrate binding site of Src kinase; inhibition of kinase activity may result in the inhibition of primary tumor growth and the suppression of metastasis. Src tyrosine kinases are upregulated in many tumor cells and play important roles in tumor cell proliferation and metastasis. Uses: Enzyme inhibitors. Alternative Names: KX01, KX-01, KX 01, KX2-391; KX-2-391; KX 2-391; KX2391; KX-2391; KX 2391; Tirbanibulin. CAS No. 897016-82-9. Molecular formula: C26H29N3O3. Mole weight: 431.53. | |
| Kyn-25-Semaglutide Sodium Salt | Kyn-25-Semaglutide Sodium Salt is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Alternative Names: H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(Oct-gamma-Glu-AEEA-AEEA)-Glu-Phe-lle-Ala-Kyn-Leu-Val-Arg-Gly-Arg-Gly-OH. Grades: 95%. Molecular formula: C186H284N45Na7O60. Mole weight: 4271.44. | |
| L-368,899 hydrochloride | L-368,899 hydrochloride is the hydrochloride salt of L-368,899, which is a non-peptide, orally active and potent oxytocin receptor antagonist with IC50 value of 8.9 nM. It displays > 40-fold selectivity over vasopressin V1a and V2 receptors. It antagonizes oxytocin-induced uterine contractions in vitro and in vivo. It may be used in the treatment of early pregnancy failure. Alternative Names: L-368,899 hydrochloride; L 368,899 hydrochloride; L368,899 hydrochloride; L368899 hydrochloride; (2S)-2-Amino-N-[(1S,2S,4R)-7,7-dimethyl-1-[[[4-(2-methylphenyl)-1-piperazinyl]sulfonyl]methyl]bicyclo[2.2.1]hept-2-yl]-4-(methylsulfonyl)butanamide; 1-((7,7-Dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo[2,2,1]heptan-1(S)-yl)methylsulfonyl)-4-(2-methylphenyl)piperazine hydrochloride. Grades: ≥97% by HPLC. CAS No. 160312-62-9. Molecular formula: C26H43N4O5S2Cl. Mole weight: 591.23. | |
| L-685,458 | L-685,458 is a potent and selective inhibitor of γ-secretase (IC50 = 17 nM) that shows 50-fold selectivity over a variety of aspartyl proteases. It also inhibits Aβ40 and Aβ42 peptides (in human neuroblastoma cells: IC50=48 and 67 nM respectively). Uses: Gamma secretase inhibitors and modulators. Alternative Names: L-685458; tert-butyl N-[(2S,3R,5R)-6-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl]carbamate. Grades: >98%. CAS No. 292632-98-5. Molecular formula: C39H52N4O6. Mole weight: 672.85. | |
| L-750,667 trihydrochloride | L-750,667 trihydrochloride. Alternative Names: 3-[4-(4-Iodophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride. Grades: 95%. CAS No. 1021868-80-3. Molecular formula: C18H22Cl3IN4. Mole weight: 527.66. | |
| L-778123 HCl | L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. Alternative Names: 4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile hydrochloride; L778123; L-778123; L 778123; L778,123; L-778,123; L 778,123 HCl. Grades: 98%. CAS No. 253863-00-2. Molecular formula: C22H20ClN5O. Mole weight: 405.88. | |
| Labd-13(E)-ene-8α,15-diol | Labd-13-ene-8,15-diol is a natural diterpenoid found in the fruits of Zizyphus jujuba. Alternative Names: (1R,2R,4aS,8aS)-1-((E)-5-hydroxy-3-Methylpent-3-en-1-yl)-2,5,5,8a-tetraMethyldecahydronaphthalen-2-ol. Grades: >98%. CAS No. 10267-31-9. Molecular formula: C20H36O2. Mole weight: 308.5. | |
| Labetalol EP Impurity A | Labetalol EP Impurity A. CAS No. 2726492-68-6. | |
| Lactoferrin from Bovine milk | Lactoferrin from Bovine milk. CAS No. 936541-36-5. | |
| L-α-Aspartyl-D-phenylalanine methyl ester | L-α-Aspartyl-D-phenylalanine methyl ester, a dipeptide compound, bears promise in the biomedical sector for its potential inhibitory impact on angiotensin converting enzyme (ACE), thus potentially reducing blood pressure levels. It has also shown potential in the treatment of hypertensive, cardiac failure, and other cardiovascular conditions. The study of its properties continues to generate interest and attention from academia and the scientific community. Alternative Names: L-alpha-Aspartyl-D-phenylalanine methyl ester. CAS No. 22839-65-2. Molecular formula: C14H18N2O5. Mole weight: 294.3. | |
| L-α-Dipalmitoylphosphatidic acid | L-α-Dipalmitoylphosphatidic acid. CAS No. 7091-44-3. | |
| λ-Cyhalothrin-(phenoxy-[d5]) | λ-Cyhalothrin-(phenoxy-d5) is an isotopic labeled form of λ-Cyhalothrin; an insecticide and pyrethrin analog. Alternative Names: gamma-Cyhalothrin-d5. CAS No. 2140302-00-5. Molecular formula: C23H14D5ClF3NO3. Mole weight: 454.88. | |
| Lansoprazole EP Impurity B | An impurity of lansoprazole, a proton pump inhibitor (PPI) used to treat the symptoms of gastroesophageal reflux disease (GERD). Alternative Names: 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfonyl]-1H-benzimidazole; AG 1813; Lansoprazole Sulfone; Lansoprazole Related Compound A. Grades: > 95%. CAS No. 131926-99-3. Molecular formula: C16H14F3N3O3S. Mole weight: 385.37. | |
| Lansoprazole N-oxide | An impurity of lansoprazole, a proton pump inhibitor (PPI) used to treat the symptoms of gastroesophageal reflux disease (GERD). Alternative Names: 2-[[[3-Methyl-1-oxido-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole. Grades: > 95%. CAS No. 213476-12-1. Molecular formula: C16H14F3N3O3S. Mole weight: 385.37. | |
| Lansoprazole Related Compound 3 | Lansoprazole impurity. Alternative Names: N-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl Lansoprazole Sulfide; 1-[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]thio]-1H-benzimidazole. Grades: > 95%. CAS No. 1083100-27-9. Molecular formula: C25H22F6N4O2S. Mole weight: 556.53. | |
| Lansoprazole Thioxo Impurity | Lansoprazole impurity. Alternative Names: 1-Methyl-12-thioxopyrido[1,2,3,4]imidazole-[1,2-a]benzimidazole-2(12H)-one. Grades: > 95%. CAS No. 1246819-06-6. Molecular formula: C14H9N3OS. Mole weight: 267.31. | |
| Lapatinib | Lapatinib, used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively. Uses: Antineoplastic agents; protein kinase inhibitors. Alternative Names: GW-572016; GSK-572016; GSK 572016. Grades: >98%. CAS No. 231277-92-2. Molecular formula: C29H26ClFN4O4S. Mole weight: 581.06. | |
| Lapatinib Ditosylate | Lapatinib is a synthetic, orally-active quinazoline with potential antineoplastic activity. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types. Uses: Antineoplastic agents. Alternative Names: GW-572016; GW 572016; GW572016. Grades: >98%. CAS No. 388082-77-7. Molecular formula: C29H26ClFN4O4S.2C7H8O3S. Mole weight: 925.46. | |
| Lapatinib Hydroxylamine | a complex used in human metabolism of lapatinib which is a dual kinase inhibitor. Alternative Names: N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[hydroxy[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine. Grades: > 95%. CAS No. 1360431-86-2. Molecular formula: C29H26ClFN4O5S. Mole weight: 597.07. | |
| Lappaconitine | Lappaconitine, extracted form the roots of Aconitum carmichaeli Debx, has neurotoxic, cardiotoxic and strong analgesic activities that does not involve the opioid receptor, and further suggest that the central nervous system may be involved in the action. Alternative Names: (+)-Lappacontine; Acetyl-10-deoxysepaconitine; Aconitane-4,8,9-triol, 20-ethyl-1,14,16-trimethoxy-, 4-(2-acetylamino)benzoate), (1-alpha,14-alpha,16-beta)-. Grades: >98%. CAS No. 32854-75-4. Molecular formula: C32H44N2O8. Mole weight: 584.70. | |
| Laropiprant | a drug used in combination with niacin to reduce blood cholesterol (LDL and VLDL) that is no longer sold. Uses: A potent, selective dp1 receptor antagonist. Alternative Names: (3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)-cyclopent[b]indole-3-acetic acid. Grades: > 95%. CAS No. 571170-77-9. Molecular formula: C21H19ClFNO4S. Mole weight: 435.91. | |
| Larotaxel | Larotaxel is a semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier. Alternative Names: XRP9881; PNU 100940. CAS No. 156294-36-9. Molecular formula: C45H53NO14. Mole weight: 831.912. | |
| L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate | L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate is a stable derivative of vitamin C. It can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). Alternative Names: 2-Phospho-L-ascorbic acid magnesium hydrate. CAS No. 1713265-25-8. Molecular formula: C6H6O9P.3/2Mg.xH2O. Mole weight: 289.54 (anhydrous basis). | |
| Lasofoxifene tartrate | Lasofoxifene tartrate is the tartrate salt form of Lasofoxifene. Lasofoxifene is a third-generation selective estrogen receptor modulators (SERMs). Alternative Names: CP-336156; CP 336156; CP336156; (2R,3R)-2,3-dihydroxybutanedioic acid;(5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol; LASOFOXIFENE HCL;(5R,6S)-5,6,7,8-Tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2-naphthalenol (2S,3S)-2,3-dihydrox. Grades: 95%. CAS No. 190791-29-8. Molecular formula: C28H31NO2.C4H6O6. Mole weight: 563.65. | |
| Latanoprostene Bunod | Latanoproste bunod is a nitric oxide-donating prostaglandin F2α (FP) receptor agonist. Under the trade name Vyzulta, it has been approved for the treatment of intraocular pressure in patients with open-angle glaucoma or ocular hypertension in 2017. Alternative Names: BOL-303259-X; NCX 116; PF-3187207. Grades: ≥95%. CAS No. 860005-21-6. Molecular formula: C27H41NO8. Mole weight: 507.62. | |
| Latinone | Latinone, a member of the macrolide antibiotic class, is a highly effective drug that promptly halts the propagation and procreates curtailment in various types of bacterial infections occurring in the urinary tract, skin, and pneumonia. This striking agent is contraindicated in viral disorders and should only be administered for bacterial infections. Alternative Names: latinone; 79157-36-1; starbld0000931; CHEMBL453557; HY-N7326. Grades: 98.0%. CAS No. 79157-36-1. Molecular formula: C22H16O5. Mole weight: 360.366. | |
| Laurifoline | Laurifoline isolated from the herbs of Lindera aggregata. Uses: Anti-hbv activities. Alternative Names: (6aS)-5,6,6a,7-Tetrahydro-1,9-dihydroxy-2,10-dimethoxy-6,6-dimethyl-4H-dibenzo[de,g]quinolin-6-ium. Grades: 96%. CAS No. 7224-61-5. Molecular formula: C20H24NO4. Mole weight: 342.4. | |
| LB-100 | LB-100 is a water-soluble protein phosphatase 2A (PP2A) inhibitor (IC50 = 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells) that enhanced the effects of sorafenib in HCC cells only during hypoxic environments. Alternative Names: (1S,4R)-2-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-3-carboxylic acid; LB 100; LB100. CAS No. 1632032-53-1. Molecular formula: C13H20N2O4. Mole weight: 268.31. | |
| L-Biopterin | L-Biopterin is an oxidation product from the melanogenesis regulating cofactor (6R)5,6,7,8 tetrahydrobiopterin (6-BH4). It is an important cofactor in the production of many essential neurotransmitters, such as dopamine, seratonin and epinephrine, and plays an important role in the production of nitric oxide in the body. It has been shown to be cytotoxic to melanocytes in vitro, and may be a useful noninvasive biomarker. Alternative Names: L-Biopterin; NSC 339699; NSC-339699; NSC339699; AR 1D8544; AR-1D8544; AR1D8544; LS126316; LS-126316; LS 126316; 2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-4(1H)-pteridinone; (-)-Biopterin; 6-Biopterin; Biopterin; L-erythro-Biopterin; NSC 339699; Pterin H B2; (1'R,2'S)-Biopterin; L-erythro-6-(1,2-Dihydroxypropyl)pterin. Grades: >95%. CAS No. 22150-76-1. Molecular formula: C9H11N5O3. Mole weight: 273.22. | |
| LCKLSL acetate | LCKLSL acetate is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. Grades: 98%. Molecular formula: C32H61N7O10S. Mole weight: 735.93. | |
| LCL-161 | LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity. SMAC mimetic LCL161 binds to IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9, which play essential roles in apoptosis (programmed cell death), necrosis and inflammation. Alternative Names: LCL161; LCL 161; LCL-161. CAS No. 1005342-46-0. Molecular formula: C26H33FN4O3S. Mole weight: 500.633. | |
| LCS3 | LCS3 is a reversible inhibitor of glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50 of 3.3 μM and 3.8 μM, respectively. CAS No. 109844-92-0. Molecular formula: C11H7ClN2O4. Mole weight: 266.64. | |
| LDC1267 | LDC1267 is a highly selective TAM kinase inhibitor with IC50 of <5 nM, 8 nM, and 29 nM for Mer, Tyro3, and Axl, respectively. Displays lower activity against Met, Aurora B, Lck, Src, and CDK8. Alternative Names: LDC1267; LDC 1267; LDC-1267. Grades:>98%. CAS No. 1361030-48-9. Molecular formula: C30H26F2N4O5. Mole weight: 560.55. | |
| LDCA | LDCA is a dual-hit metabolic modulator and inhibits LDH-A enzyme activity to stimulate apoptosis in the malignant population. LDCA can be used for the research of oncogenic progression. Alternative Names: 2,2-Dichloro-N-(3-chloro-4-fluorophenyl)acetamide. CAS No. 349106-80-5. Molecular formula: C8H5Cl3FNO. Mole weight: 256.49. | |
| LDN-193189 | LDN193189 is a selective and potent ALK inhibitor with potential anticancer activity. Uses: Differentiation. Alternative Names: 4-[6-(4-Piperazin-1-yl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline; LDN193189; LDN 193189; LDN-193189. Grades: 0.98. CAS No. 1062368-24-4. Molecular formula: C25H22N6. Mole weight: 406.48238. | |
| LDN-212854 | LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2. LDN-212854 exhibits some selectivity for ALK2 in preference to other BMP type I receptors, ALK1 and ALK3, which may permit the interrogation of ALK2-mediated signaling, transcriptional activity, and function. LDN-212854 potently inhibits heterotopic ossification in an inducible transgenic mutant ALK2 mouse model of fibrodysplasia ossificans progressiva. Alternative Names: BMP Inhibitor III; LDN 212854; 5-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline. Grades: >98%. CAS No. 1432597-26-6. Molecular formula: C25H22N6. Mole weight: 406.48. | |
| LDN-27219 | LDN-27219 is a revesible inhibitor of transglutaminase 2 (TG2) that binds to the GTP binidng site of the enzyme with an IC50 value of 0.6 μM. LDN-27219 effectively decreases blood pressure and induces vasodilation, it can be used for the research of cardiovascular disease. Alternative Names: LDN 27219; LDN27219; 2-((4-oxo-3,5-diphenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetohydrazide. Grades: 98%. CAS No. 312946-37-5. Molecular formula: C20H16N4O2S2. Mole weight: 408.50. | |
| LDS 867 | LDS 867 is a potent and selective protein kinase D (PKD) inhibitor used in the biomedical industry for research on cancer treatment. It effectively inhibits PKD and displays anticancer activity against a range of malignancies, including breast and pancreatic cancers. LDS 867 is a valuable tool in the study of PKD signaling pathways and potential therapeutic strategies for various diseases. Alternative Names: Benzothiazolium, 2-[[4-[4-[4-(dimethylamino)phenyl]-1,3-butadienyl]-2H-1-benzopyran-2-ylidene]methyl]-3-ethyl perchlorate. CAS No. 106025-71-2. Molecular formula: C31H29N2OS?ClO4. Mole weight: 577.1. | |
| Ledipasvir acetone | Ledipasvir is an inhibitor of hepatitis C virus NS5A. Alternative Names: GS 5885 acetone; GS5885 acetone; GS-5885 acetone; methyl ((S)-1-((S)-6-(5-(9,9-difluoro-7-(2-((1R,3S,4S)-2-((methoxycarbonyl)-L-valyl)-2-azabicyclo[2.2.1]heptan-3-yl)-1H-benzo[d]imidazol-6-yl)-9H-fluoren-2-yl)-1H-imidazol-2-yl)-5-azaspiro[2.4]heptan-5-yl)-3-methyl-1-oxobutan-2-yl)carbamate compound with propan-2-one (1:1). Grades: >98%. CAS No. 1441674-54-9. Molecular formula: C52H60F2N8O7. Mole weight: 947.08. | |
| LEE011 succinate | LEE011 is an orally bioavailable and highly specific CDK4/6 (cyclin-dependent kinase 4/6) inhibitor. LEE011 in combination with LGX818 (a V600E BRAF specific inhibitor) or BYL719 (a PIK3CA specific inhibitor) leads to robust anti-tumor activity in melanoma and breast cancer tumor models. Alternative Names: Ribociclib succinate; LEE 011 succinate; LEE-011 succinate. Grades: >98%. CAS No. 1374639-75-4. Molecular formula: C27H36N8O5. Mole weight: 552.63. | |
| Lehmbachol D | Lehmbachol D is a natural compound, aidng in the research of skin infections and inflammatory maladies. Grades: 97.5%. CAS No. 913556-40-8. Molecular formula: C26H26O8. Mole weight: 466.488. | |
| Lenvatinib | Lenvatinib (E7080) is a multi-target inhibitor, mostly for VEGFR2(KDR)/VEGFR3(Flt-4) with IC50 of 4 nM/5.2 nM, less potent against VEGFR1/Flt-1, ~10-fold more selective for VEGFR2/3 against FGFR1, PDGFRα/β. Alternative Names: 4-[3-chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-6-quinolinecarboxamide; E-7080; E 7080; E7080; ER-203492-00. Grades: >98%. CAS No. 417716-92-8. Molecular formula: C21H19ClN4O4. Mole weight: 426.85. | |
| Lepzacitinib | Lepzacitinib. CAS No. 2321488-47-3. | |
| L-(+)-Ergothioneine-[d3] | L-(+)-Ergothioneine-[d3] is a stable isotope analogue of L-(+)-Ergothioneine. It is a natural molecule isolated from the rye ergot fungus and later identified in rat erythrocytes and liver and in numerous other animal tissues. Its antioxidizing properties may afford the compound therapeutic potential or it may be used as a food additive or in cosmetics. Alternative Names: (αS)-α-Carboxy-2,3-dihydro-N,N,-dimethyl-N-(methyl-d3)-2-thioxo-1H-imidazole-4-ethanaminium Inner Salt; 2-Mercaptohistidine-d3 Betaine; 2-Mercapto-N,N-dimethylhistidine Methyl Ester Betaine-d3; 2-Mercaptohistidine-d3; L-(+)-Ergothioneine D3. Grades: 95% by CP; 99% atom D. CAS No. 1356933-89-5. Molecular formula: C9H12D3N3O2S. Mole weight: 232.32. | |
| Lesinurad | Lesinurad(RDEA594), once-daily inhibitor of URAT1, is a transporter in the kidney that regulates uric acid excretion from the body. Alternative Names: 2-[[5-Bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]acetic acid; RDEA 594; Zurampic; [[5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-acetic Acid; Lesinida. Grades: >98%. CAS No. 878672-00-5. Molecular formula: C17H14BrN3O2S. Mole weight: 404.28. | |
| Lesinurad Impurity 16 | An intermediate of Lesinurad, a urate transporter inhibitor used for the treatment of high blood uric acid levels associated with gout. Alternative Names: Methyl 2-(5-broMo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetate. Grades: > 95%. CAS No. 878671-99-9. Molecular formula: C18H16BrN3O2S. Mole weight: 418.32. | |
| (+)-Leucocyanidin | Leucocyanidin is a natural compound extracted from Litchi Chinensis. Alternative Names: 2,3-trans-3,4-trans-leucocyanidin; Trans,trans-Leucocyanidin. Grades: > 95%. CAS No. 69256-15-1. Molecular formula: C15H14O7. Mole weight: 306.27. | |
| Leuconolam | Leuconolam comes from the herbs of Alstonia scholaris. Alternative Names: (8aR,12aS,14bS)-8a-Ethyl-7,8,8a,10,11,12a-hexahydro-12a-hydroxyindolizino[8,1-ef][1]benzazonine-6,13(5H,9H)-dione. Grades: 0.97. CAS No. 93710-27-1. Molecular formula: C19H22N2O3. Mole weight: 326.4. | |
| Leucosceptoside A | Leucosceptoside A is a natural compound isolated from the dried roots of Clerodendrum bungei. Grades: 97.0%. CAS No. 83529-62-8. Molecular formula: C30H38O15. Mole weight: 638.619. | |
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