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| Product | Description | |
|---|---|---|
| Glabralide A | Glabralide A is a kind of a unique skeleton of the chalcone-coupled monoterpenoid. It has a bicyclo [2.2.2] octene core unit with five chiral centers. Alternative Names: Glabralide A; 1969289-10-8; B0005-267493. Grades: 97.0%. CAS No. 1969289-10-8. Molecular formula: C27H32O5. Mole weight: 436.00. |  |
| Glabralide B | Glabralide B is an enchanting natural compound, manifesting an impeccable amalgamation of anti-inflammatory and antioxidant effects. Alternative Names: Glabralide B; 2170388-84-6; AKOS040760805. Grades: 98.0%. CAS No. 2170388-84-6. Molecular formula: C21H26O3. Mole weight: 326.436. | |
| Glabralide C | Glabralide C, an organic compound derived from the Astragalus glabrescens blossoms, has been shown to exhibit neuroprotection and could be a promising treatment for neurodegenerative disorders like Alzheimer's. Alternative Names: Glabralide C; 2170388-85-7. Grades: 96.0%. CAS No. 2170388-85-7. Molecular formula: C29H40O4. Mole weight: 452.634. | |
| Glabranin | Glabranin is a natural flavonoid isolated from the roots of Glycyrrhiza uralensis Fisch. Alternative Names: (2S)-2,3-Dihydro-5,7-dihydroxy-8-(3-methyl-2-buten-1-yl)-2-phenyl-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-8-(3-methyl-2-butenyl)-2-phenyl-, (2S)-; 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-8-(3-methyl-2-butenyl)-2-phenyl-, (S)-; Glabranin (flavonoid); Glabranine; 8-Prenylpinocembrin; 8-Dimethylallylpinocembrin. Grades: >98%. CAS No. 41983-91-9. Molecular formula: C20H20O4. Mole weight: 324.37. | |
| Glabratine | Glabratine is a glucoalkaloid isolated from Uncaria glabrata. Grades: 97.5%. CAS No. 142750-47-8. Molecular formula: C27H34N2O9. Mole weight: 530.575. | |
| Glabredelphinine | Glabredelphinine, a naturally occurring substance, has garnered attention for its remarkable efficacy in inducing apoptosis in tumors, thus displaying its potent anti-tumor activity. Furthermore, it has exhibited potential therapeutic benefits in the treatment of Alzheimer's disease by impeding acetylcholinesterase activity. Through its multifaceted mechanisms, Glabredelphinine represents an intriguing candidate for further exploration within both oncological and neurological research domains. Alternative Names: Glabredelphinine; 132160-37-3; (3R,4S,5S,6S,8R,13R,16S,17R,18S)-11-ethyl-6-methoxy-13-methyl-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadec-14-ene-4,8,9,16,18-pentol(2R,3R,4S,5S,6S,8R,13R,16S,17R,18S)-11-ethyl-6-methoxy-13-methyl-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadec-14-ene-4,8,9,16,18-pentol. Grades: 97.5%. CAS No. 132160-37-3. Molecular formula: C22H33NO6. Mole weight: 407.507. | |
| Glabrol | Glabrol is a flavonoid showing inhibition of PTP1B and CYP1B1. Alternative Names: Glabrol; 59870-65-4; UNII-E4XEY076JN; E4XEY076JN; (S)-7-Hydroxy-2-(4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl)-8-(3-methylbut-2-en-1-yl)chroman-4-one; MLS000697605; (2S)-7-hydroxy-2-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one; SMR000470942; 7-Hydroxy-2-(4-hydroxy-3-((E)-3-methyl-but-2-enyl)-phenyl)-8-(3-methyl-but-2-enyl)-1-benzopyran-4-one; 4H-1-BENZOPYRAN-4-ONE, 2,3-DIHYDRO-7-HYDROXY-2-(4-HYDROXY-3-(3-METHYL-2-BUTEN-1-YL)PHENYL)-8-(3-METHYL-2-BUTEN-1-YL)-, (2S)-; 4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxy-3-(methyl-2-butenyl)phenyl)-8-(3-methyl-2-butenyl)-, (2S)-. Grades: 98%. CAS No. 59870-65-4. Molecular formula: C25H28O4. Mole weight: 392.49. | |
| Glasdegib | Glasdegib is an orally bioavailable small-molecule inhibitor of the Hedgehog (Hh) signaling pathway that binds to Smoothened (Smo) and inhibits signal transduction. It has been shown to attenuate leukemia stem cell self-renewal and cell cycle progression in primary acute myeloid leukemia cells and in an in vivo Drosophila model. Alternative Names: PF-04449913; PF 04449913; 1-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl]-3-(4-cyanophenyl)urea. Grades: >98%. CAS No. 1095173-27-5. Molecular formula: C21H22N6O. Mole weight: 374.44. | |
| Glaucocalyxin A | Glaucocalyxin A, which is extracted from the herbs of Rabdosia rubescens, inhibited Akt phosphorylation, suppressed proliferation, and promoted apoptosis in a dose-dependent manner, but not in normal glial cells. Glaucocalyxin A activated caspase-3, decreased BAD phosphorylation, and reduced the expression of X-linked inhibitor of apoptosis protein. Glaucocalyxin A inhibited collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GP? pathway. Uses: Antiplatelet / antithrombotic. Alternative Names: LeukaMenin F; Wangzaozin B; Leucamenin F. Grades: >98%. CAS No. 79498-31-0. Molecular formula: C20H28O4. Mole weight: 332.43. | |
| Glaucocalyxin B | Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anti-inflammatory effects. Alternative Names: HY-N2113. Grades: 98%. CAS No. 80508-81-2. Molecular formula: C22H30O5. Mole weight: 374.47. | |
| Glimepiride-[d4] | Glimepiride-[d4] is a labelled analogue of Glimepiride. Glimepiride is a sulfonylurea hypoglycemic agent used as an antidiabetic. Alternative Names: Glimepiride D4. Grades: 95% by HPLC; 95% atom D. CAS No. 1131981-29-7. Molecular formula: C24H30D4N4O5S. Mole weight: 494.64. | |
| Glimepiride Impurity A | Glimepiride Impurity A is the cis-isomer of Glimepiride found in a bulk drug substance. Glimepiride is an antidiabetic medication used to treat type 2 diabetes. Alternative Names: 1-[[p-[2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl]phenyl]sulfonyl]-3-(cis-4-methylcyclohexyl)urea; 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(cis-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide; Gl. Grades: > 95%. CAS No. 684286-46-2. Molecular formula: C24H34N4O5S. Mole weight: 490.63. | |
| Glimepiride Impurity I | An impurity of Glimepiride, an antidiabetic medication used to treat type 2 diabetes. Alternative Names: ortho-Glimepiride Impurity; 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[2-[[[[(trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide; Glimepride 2-Isomer; Glimepiride ortho isomer. Grades: ≥95%. CAS No. 878480-70-7. Molecular formula: C24H34N4O5S. Mole weight: 490.63. | |
| Glomeratose A | Glomeratose A is a phenylpropanoid isolated from Polygala tenuifolia. Alternative Names: GlomeratoseA; BCP25315; FT-0777097. Grades: 98%. CAS No. 202471-84-9. Molecular formula: C24H34O15. Mole weight: 562.52. | |
| GLPG-0187 | GLPG-0187 is a small molecule integrin receptor antagonist (IRA) with nanomolar affinity for the RGD-integrin receptors αvβ1, αvβ3, αvβ5, αvβ6 and α5β1 (IC50s = 1.2-3.7 nM). Integrin receptors are expressed on the surface of tumor vessel endothelial cells and some types of cancer cells, and play a crucial role in endothelial cell adhesion and migration. This compound shows an inhibitory activity of angiogenesis, bone-resorption and tumor, which is hopefully used as an anticancer drug. Uses: An integrin receptor antagonist (ira) can be used as an anticancer drug. Alternative Names: GLPG0187; GLPG 0187; GLPG-0187; UNII-43A5P87Z4T; 43A5P87Z4T; SCHEMBL2372722; CHEMBL3319236; (2S)-3-[[2,5-dimethyl-6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidin-1-yl]pyrimidin-4-yl]amino]-2-[(4-methoxyphenyl)sulfonylamino]propanoic acid. Grades: ≥98 %. CAS No. 1320346-97-1. Molecular formula: C29H37N7O5S. Mole weight: 595.719. | |
| GLPG-1690 | GLPG-1690, an imidazopyridine derivative, has been found to be a selective autotaxin inhibitor that could probably be effective as an anti-inflammatory agent and is under Phase II trial against Idiopathic pulmonary fibrosis (IPF). Alternative Names: Ziritaxestat; GLPG 1690; GLPG1690; 2-((2-ethyl-6-(4-(2-(3-hydroxyazetidin-1-yl)-2-oxoethyl)piperazin-1-yl)-8-methylimidazo[1,2-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile. Grades: >98%. CAS No. 1628260-79-6. Molecular formula: C30H33FN8O2S. Mole weight: 588.71. | |
| Glucocorticoid receptor modulator 1 | Glucocorticoid receptor modulator 1. CAS No. 2868357-11-1. | |
| Glutamate dehydrogenase (NAD(P)) | Glutamate dehydrogenase (NAD(P)). CAS No. 9029-12-3. | |
| Glycine Bisphosphonate | Glycine Bisphosphonate is a possible inhibitor of the plant vacuolar proton-pumping pyrophosphatase. Alternative Names: 2-Amino-1-hydroxyethylene-1,1-bisphosphonic Acid; Ethane-1-hydroxy-2-amino-1,1-diphosphonic Acid. Grades: > 95%. CAS No. 41003-10-5. Molecular formula: C2H9NO7P2. Mole weight: 221.04. | |
| Glycitein | Glycitein is a soybean (yellow cultivar) isoflavonoid. It may be used to study anti-oxidation processes at the level of gene transcription where it increases the binding of transcription factors [nuclear factor-E2-related factor 2 (Nrf2) and c-Jun] to the antioxidant response element (ARE) on HO-1 and NQO1 promoters. Uses: The compund shows an anti-cancer activity. Alternative Names: 7-Hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-; 7-Hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4-chromenone; 4',7-Dihydroxy-6-methoxyisoflavone. Grades: >98%. CAS No. 40957-83-3. Molecular formula: C16H12O5. Mole weight: 284.26. | |
| Glycopyrrolate Bromide | Glycopyrrolate bromide is a muscarinic competitive antagonist used as an antispasmodic. Uses: Adjuvants, anesthesia. Alternative Names: 3-[(2-Cyclopentyl-2-hydroxy-2-phenylacetyl)oxy]-1,1-dimethylpyrrolidinium Bromide; 3-Hydroxy-1,1-dimethylpyrrolidinium Bromide α-Cyclopentylmandelate; AHR-504; Asecryl; Copyrrolate; Gastrodyn; NSC 250836; NVA 237; Nodapton; Robanul; Robinul; Tarodyl; Tarodyn; Glycopyrrolate; GLYCOPYRROLATE; Glycopyrronium bromide; Gastrodyn; NVA-237; NVA237. Grades: 98%. CAS No. 596-51-0. Molecular formula: C19H28BrNO3. Mole weight: 398.33. | |
| Glycopyrrolate Erythro Isomer (RR/SS-Isomer) | Glycopyrrolate Erythro Isomer is one of Glycopyrrolate impurities. Glycopyrrolate is an anticholinergic agent with antispasmodic activity used to treat gastrointestinal conditions associated. Alternative Names: Glycopyrrolate bromide; glycopyrronium bromide; (1,1-dimethylpyrrolidin-1-ium-3-yl) 2-cyclopentyl-2-hydroxy-2-phenylacetate bromide. Grades: > 95%. Molecular formula: C19H28NO3Br. Mole weight: 398.34. | |
| Glycopyrronium Bromide EP Impurity I | Glycopyrrolate Impurity I is an impurity of Glycopyrrolate, which is an anticholinergic agent with antispasmodic activity used to treat gastrointestinal conditions associated. Alternative Names: 3-[[2-(4-Chlorophenyl)-2-cyclopentyl-2-hydroxyacetyl]oxy]-1,1-dimethyl pyrrolidinium Bromide. Grades: > 95%. CAS No. 1404453-68-4. Molecular formula: C19H27ClNO3Br. Mole weight: 432.78. | |
| Glycozolinine | Glycozolinine isolated from the herbs of Micromelum sp. Uses: Antibacterial; antimicrobial. Alternative Names: 6-Methyl-9H-carbazol-3-ol; Glycozolinol. Grades: > 95%. CAS No. 5257-8-9. Molecular formula: C13H11NO. Mole weight: 197.2. | |
| Glycycoumarin | Glycycoumarin is a natural coumarin compound found in several plants. Alternative Names: 3-(2,4-Dihydroxyphenyl)-7-hydroxy-5-methoxy-6-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one. Grades: >98%. CAS No. 94805-82-0. Molecular formula: C21H20O6. Mole weight: 368.38. | |
| Glycyrrhisoflavone | Glycyrrhisoflavone is a natural flavonoid compound found in several plants. Alternative Names: 3-[3,4-Dihydroxy-5-(3-methyl-2-butenyl)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one. Grades: >98%. CAS No. 116709-70-7. Molecular formula: C20H18O6. Mole weight: 354.35. | |
| GlyH-101 | N-2-Naphthalenyl-glycine 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide is a glycine hydrazide that has recently been shown to block CFTR channels. However, its effects on cardiomyocytes are unknown. Studies have demonstrated that GlyH-101 blocks cardiac I Cl.PKA channels in a similar fashion to that reported for recombinant CFTR. Alternative Names: GlyH 101; GlyH101. Grades: >98%. CAS No. 328541-79-3. Molecular formula: C19H15Br2N3O3. Mole weight: 493.15. | |
| Gly-His-Lys acetate salt | Gly-His-Lys acetate salt. CAS No. 72957-37-0. | |
| GNE-3511 | GNE-3511 has been found to be a DLK, MAP3K12 kinase inhibitor that could probably exhibit protection action of primary neurons. IC50: 0.107 uM (DLK). Alternative Names: GNE-3511; GNE 3511; GNE3511. CHEMBL3393333; SCHEMBL15602439; BDBM50059190; 2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile. Grades: 98%. CAS No. 1496581-76-0. Molecular formula: C23H26F2N6O. Mole weight: 440.50. | |
| GNE-6776 | GNE-6776 is a potent and non-covalent USP7 inhibitor with IC50 of 1.34 uM. GNE-6776 targets cellular USP7, MDM2, and p53 signalling pathways, and induces tumor cell death. Alternative Names: GNE 6776; GNE-6776; GNE6776; 5-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridyl]-N-methyl-pyridine-2-carboxamide. Grades: 98%. CAS No. 2009273-71-4. Molecular formula: C20H20N4O2. Mole weight: 348.406. | |
| GNE-7915 | GNE-7915 is a potent, selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 9 nM. Alternative Names: GNE7915; GNE 7915; GNE-7915. CAS No. 1351761-44-8. Molecular formula: C19H21F4N5O3. Mole weight: 443.403. | |
| GNF 5837 | GNF 5837 is a potent and selective pan-Trk inhibitor that blocks tumor gowth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF. GNF 5837 displays antiproliferative effects in cellular Ba/F3 assays with IC50 values of 7, 9 and 11 nM for cells expressing Tel-TrkC, Tel-TrkB and Tel-TrkA respectively. Alternative Names: GNF5837; GNF-5837; GNF 5837. 1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[4-methyl-3-[[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-6-yl]amino]phenyl]urea. CAS No. 1033769-28-6. Molecular formula: C28H21F4N5O2. Mole weight: 535.503. | |
| Golgicide A | Golgicide A is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1. Golgicide A inhibited HSV-1 entry via beta-galactosidase reporter assay and impaired incoming virus transport to the nuclear periphery. Alternative Names: GCA; (3aR,9bS)-rel-6,8-Difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-3H-cyclopenta[c]quinoline; 3H-Cyclopenta[c]quinoline, 6,8-difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-, (3aR,9bS)-. Grades: ≥98%. CAS No. 1139889-93-2. Molecular formula: C17H14F2N2. Mole weight: 284.30. | |
| Golvatinib | golvatinib (also known as E7050) is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity. c-Met / VEGFR kinase inhibitor E7050 binds to and inhibits the activities of both c-Met and VEGFR-2, which may inhibit tumor cell growth and survival of tumor cells that overexpress these receptor tyrosine kinases. c-Met and VEGFR-2 are upregulated in a variety of various tumor cell types and play important roles in tumor cell growth, migration and angiogenesis. Alternative Names: E7050; E-7050; E 7050; Golvatinib. CAS No. 928037-13-2. Molecular formula: C33H37F2N7O4. Mole weight: 633.701. | |
| Gomisin A | Schisandrol B is one of its major active constituents of traditional hepato-protective Chinese medicine, Schisandra sphenanthera. Uses: Antineoplastic; anti-inflammatory. Alternative Names: Gomisin-A; Besigomsin; TJN-101; Wuweizi alcohol-B; Wuweizichun-B. Grades: >98%. CAS No. 58546-54-6. Molecular formula: C23H28O7. Mole weight: 416.46. | |
| Gomisin D | Gomisin D is an inherent natural compound hailing from herbal medicine, used for studying maladies such as hepatitis. Alternative Names: 5,13-(Epoxybutanoxy)benzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-18-one,5,6,7,8-tetrahydro-6,17-dihydroxy-1,2,3-trimethoxy-6,7,16,17-tetramethyl-,(5S,6S,7S,13aR,16R,17R)-;(11S,12R,15S,24S,25S)-12,25-Dihydroxy-18,19,20-trimethoxy-11,12,24,25-tetramethyl-4,6,9,14-tetraoxapentacyclo[13.7.3.0sup3,7sup.0sup8,22sup.0sup16,21sup]pentacosa-1(22),2,7,16,18,20-hexaen-13-one;7,19-dihydroxy-12,13,14-trimethoxy-6,7,18,19-tetramethyl-6,7-dihydro-5H-10,15-propano[1,3]dioxolo[4',5':5,6]benzo[1,2-g]benzo[i][1,6]dioxacycloundecin-8(10H)-one. Grades: >98%. CAS No. 60546-10-3. Molecular formula: C28H34O10. Mole weight: 530.56. | |
| Gomisin G | Gomisin G exhibited the most potent anti-HIV activity with EC50 and therapeutic index (TI) values of 0.006 microgram/mL and 300. Uses: Anti-hiv. Alternative Names: Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-7,8-. Grades: >98%. CAS No. 62956-48-3. Molecular formula: C30H32O9. Mole weight: 536.6. | |
| Gomisin J | Gomisin J inhibits LPO in rat liver mitochondria and protects cultured myocardial cells from being injured by calcium paradox. Alternative Names: (6R,7S)-1,2,11,12-tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulene-3,10-diol. Grades: >98%. CAS No. 66280-25-9. Molecular formula: C22H28O6. Mole weight: 388.45. | |
| (-)Gomisin L1 | (-)Gomisin L1 is an enigmatic natural compound sourced from Schisandra chinensis illuminating its remarkable attributes as a potent modulator in the research of inflammation, cancer, Alzheimer's disease and cardiovascular disorders. Alternative Names: (-)-Gomisin L1; Gomisin L1; 82425-43-2; UNII-6HN2PJ55D76HN2PJ55D7. Grades: >98%. CAS No. 82425-43-2. Molecular formula: C22H26O6. Mole weight: 386.444. | |
| Gomisin M1 | R(+)-Gomisin M1 can be found in the fruits of Schizandra chinensis. Alternative Names: R(+)-Gomisin M1;Gomisin M1;82467-50-3;(-)Gomisin L1;Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-1-ol, 5,6,7,8-tetrahydro-2, 3,13-trimethoxy-6,7-dimethyl-, stereoisomer;DTXSID601318545;HY-N1529;AKOS040762632;DA-48556;CS-0017078;B0005-188529;B0005-465629;4,5,19-trimethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.0(2),?.0(1)?,(1)?]nonadeca-1(12),2(7),3,5,13,18-hexaen-3-ol;4,5,19-trimethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaen-3-ol. Grades: >98%. CAS No. 82467-50-3. Molecular formula: C24H28O12. Mole weight: 508.5. | |
| (+)Gomisin M2 | (+)Gomisin M2 is a lignan isolated and purified form fruits of Schizandra chinensis which is is utilized for antitussive and tonic purposes in Oriental medicine. Alternative Names: Benzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-13-ol, 5,6,7,8-tetrahydro-1,2,3-trimethoxy-6,7-dimethyl-, (6S,7R,13aR)-; Benzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-13-ol, 5,6,7,8-tetrahydro-1,2,3-trimethoxy-6,7-dimethyl-, stereoisomer; (6S,7R,13aR)-5,6,7,8-Tetrahydro-1,2,3-trimethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-13-ol; Gomisin M2. Grades: > 98%. CAS No. 82425-45-4. Molecular formula: C22H26O6. Mole weight: 386.44. | |
| GOMISIN N | Gomisin N produced beneficial sedative and hypnotic bioactivity, which might be mediated by the modification of the serotonergic and GABAergic system. Uses: Anticancer, anti-hepatotoxic, anti-oxidative and anti-inflammatory. Alternative Names: GOMISIN N; Benzo(3,4)cycloocta(1,2-F)(1,3)benzodioxole, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, (6R,7S,13as)-. Grades: >98%. CAS No. 69176-52-9. Molecular formula: C23H28O6. Mole weight: 400.46. | |
| Goralatide acetate | Goralatide is a physiological regulator of hematopoiesis and inhibits the entry into the S-phase of murine and human hematopoietic stem cells. Ac-SDKP is a physiological substrate of angiotensin I- converting enzyme (ACE). Alternative Names: N-acetyl-Ser-Asp-Lys-Pro; Acetyl-serinyl-aspartyl-lysinyl-proline acetate. Grades: 98%. Molecular formula: C22H37N5O11. Mole weight: 547.56. | |
| Gossypin | Gossypin is a pentahydroxyflavone glucoside isolated from Hibiscus vitifolius. Gossypin exhibits antioxidant, antiinflammatory, anticancer and antidiabetic activities. Alternative Names: 3,3,4,5,7,8-Hexahydroxy flavone-8-glucoside; Gossypetin 8-glucoside. CAS No. 652-78-8. Molecular formula: C21H20O13. Mole weight: 480.38. | |
| GPR34 receptor antagonist 2 | GPR34 receptor antagonist 2 is a GPR34 receptor antagonist. Grades: 97%. CAS No. 907952-06-1. Molecular formula: C31H26ClNO4. Mole weight: 512.0. | |
| Grandiflorenic acid | Grandiflorenic acid (GA) is a natural diterpenoid found in the herbs of Siegesbeckia orientalis L. Grandiflorenic acid shows the uterine responses induced by ZACE. Alternative Names: Kauradienoic acid; ent-kaura-9(11),16-dien-18-oic acid; Kaura-9(11),16-dien-18-oic acid, (4α)-; (4R,4aS,6aS,9R,11bR)-4,11b-dimethyl-8-methylene-1,2,3,4,4a,5,6,7,8,9,10,11b-dodecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylic acid; (5β,8α,10α)-Kaura-9(11),16-dien-18-oic acid. Grades: >96%. CAS No. 22338-67-6. Molecular formula: C20H28O2. Mole weight: 300.44. | |
| Grandifloric acid | Grandifloric acid is a natural diterpenoid found in the herbs of Siegesbeckia orientalis L. Alternative Names: [15S,(-)]-15α-Hydroxykaur-16-en-18-oic acid; Grandiflorolic acid; 15alpha-Hydroxykaur-16-en-19-oic acid. Grades: >98%. CAS No. 22338-69-8. Molecular formula: C20H30O3. Mole weight: 318.46. | |
| Grapiprant | Grapiprant. CAS No. 415903-37-6. | |
| Graveoline | Graveoline isolated from ethanolic extract of Ruta graveolens triggers apoptosis and autophagy in skin melanoma cells: a novel apoptosis-independent autophagic signaling pathway. Alternative Names: 2-(benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one; Foliosine; Graveolin. Grades: 96 % (HPLC). CAS No. 485-61-0. Molecular formula: C17H13NO3. Mole weight: 279.29. | |
| Griffithazanone A | Griffithazanone A is an alkaloid compound found in herbs of Goniothalamus yunnanensis. Alternative Names: (3R,4R)-3,4-Dihydro-3-hydroxy-4-methylbenzo[g]quinoline-2,5,10(1H)-trione. Grades: >96%. CAS No. 240122-30-9. Molecular formula: C14H11NO4. Mole weight: 257.2. | |
| Grifolic acid | Grifolic Acid is a selective partial GPR120 agonist. It induces ERK and [Ca2+]i responses in cells expressing GPR120, but has no effects on those expressing GPR40. Alternative Names: ilicicolinic acid B. Grades: >98%. CAS No. 80557-12-6. Molecular formula: C23H32O4. Mole weight: 372.5. | |
| Groenlandicine | Groenlandicine, a botanical-derived constituent, exhibits profound implications for biomedical applications of studying an array of afflictions, encompassing neoplastic disorders and cardiovascular impairments. Alternative Names: 11,12-Dihydro-8-methoxy-9-hydroxybenzo[a]-1,3-benzodioxolo[4,5-g]quinolizinium; 11,12-Dihydro-9-hydroxy-8-methoxybenzo[a]-1,3-benzodioxolo[4,5-g]quinolizinium; Groenlandicine; Tetrahydricheilanthifolinium; Tetrahydrocheilanthifoline; Tetradehydrocheilanthifoline. Grades: >98%. CAS No. 38691-95-1. Molecular formula: C19H16NO4+. Mole weight: 322.33464. | |
| Grossamide | Cis-Grossamide K is a natural alkaloid found in the herbs of Cannabis sativa L. Cis-Grossamide K exhibits a strong anti-melanogenic activity on the cells without high cell toxicity. Uses: Anti-melanogenic. Alternative Names: 2-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-5-[3-[2-(4-hydroxyphenyl)et hylamino]-3-oxoprop-1-enyl]-7-methoxy-2,3-dihydrobenzofuran-3-carboxamide. Grades: >97%. CAS No. 80510-06-1. Molecular formula: C36H36N2O8. Mole weight: 624.69. | |
| Grosvenorine | Grosvenorine is extracted from roots of the fruits of Siraitia grosuenorii. It has free radical scavenging activity. Alternative Names: Grosvenorin. Grades: >98%. CAS No. 156980-60-8. Molecular formula: C33H40O19. Mole weight: 740.7. | |
| GSK0660 | GSK0660 is a selective PPARδ antagonist. GSK0660 blocks the effect of TNFα on the expressions of cytokines involved in leukocyte recruitment, including CCL8, CCL17, and CXCL10, and it may block TNFα-induced retinal leukostasis. Alternative Names: GSK0660; GSK-0660; GSK 0660. Grades: 96%. CAS No. 1014691-61-2. Molecular formula: C19H18N2O5S2. Mole weight: 418.48. | |
| GSK1016790A | GSK1016790A is a novel and potent transient receptor potential vanilloid 4 (TRPV4) agonist. It has been used to demonstrate a role for TRPV4 in regulating urinary bladder activity and endothelial control of vascular tone. It elicited Ca2+ influx in mouse and human TRPV4 expressing HEK cells with EC50 values of 18 and 2.1 nM, respectively. It also evoked a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM, which is 300 fold more potent than 4a-PDD. It was developed by GlaxoSmithKline. Uses: Gsk1016790a regulats urinary bladder activity and endothelial control of vascular tone. Alternative Names: GSK1016790A; GSK-1016790A; GSK 1016790A. N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide. Grades: >98 %. CAS No. 942206-85-1. Molecular formula: C28H32Cl2N4O6S2. Mole weight: 655.61. | |
| GSK1059615 | GSK1059615 is a dual inhibitor of PI3Kα/β/δ/γ (reversible) and mTOR with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM, respectively. Alternative Names: GSK-1059615; GSK 1059615; GSK1059615. Grades: >98%. CAS No. 958852-01-2. Molecular formula: C18H11N3O2S. Mole weight: 333.36. | |
| GSK-1070916A | GSK-1070916A is an ATP-competitive inhibitor of the serine / threonine kinases Aurora B and C with potential antineoplastic activity. Aurora B/C kinase inhibitor GSK1070916A binds to and inhibits the activity of Aurora kinases B and C, which may result in inhibition of cellular division and a decrease in the proliferation of tumor cells that overexpress the Aurora kinases B and C. Aurora kinases play essential roles in mitotic checkpoint control during mitosis, and are overexpressed by a wide variety of cancer cell types. Alternative Names: GSK 1070916; GSK-1070916; GSK 1070916; GSK1070916A; GSK 1070916A; NMI-900; NMI 900; NMI900; N'-[4-[4-[2-[3-[(Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl]phenyl]-N,N-dimethylurea. Grades: 98%. CAS No. 942918-07-2. Molecular formula: C30H33N7O. Mole weight: 507.63. | |
| GSK1324726A | GSK1324726A is a novel, potent and selective small molecule inhibitor of BET proteins with high affinity to BRD2 (IC50 = 41 nM), BRD3 (IC50 = 31 nM), and BRD4 (IC50 = 22 nM). Alternative Names: I-BET-726; I-BET 726; I-BET726; GSK-1324726A; GSK 1324726A. Grades: >98%. CAS No. 1300031-52-0. Molecular formula: C25H23ClN2O3. Mole weight: 434.91. | |
| GSK 189254A | GSK-189,254 is a H3 histamine receptor inverse agonist. It has subnanomolar affinity for the H3 receptor with Ki of 0.2nM. It possesses stimulant and nootropic effects and analgesic action suggesting a role for H3 receptors in pain processing in the spinal cord. No development was reported about Phase-II clinical trials for Narcolepsy in Europe. Uses: Narcolepsy. Alternative Names: 6-((3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy)-N-methyl-3-Pyridinecarboxamide. Grades: 98%. CAS No. 720690-73-3. Molecular formula: C21H25N3O2. Mole weight: 351.44. | |
| GSK-2256098 | GSK2256098, also known as GTPL7939, is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. Alternative Names: GSK2256098; GSK 2256098; GSK-2256098; GTPL7939; GTPL-7939; GTP L7939. Grades: 98%. CAS No. 1224887-10-8. Molecular formula: C20H23ClN6O2. Mole weight: 414.89. | |
| GSK 2606414 | GSK 2606414 is a potent and selective PERK inhibitor that suppresses PERK activation in cells and inhibits the growth of a human tumor xenograft in mice. Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states. Evidence that PERK is implicated in tumorigenesis and cancer cell survival stimulated our search for small-molecule inhibitors. Alternative Names: GSK2606414; GSK-2606414; GSK 2606414; GSK PERK Inhibitor. 1-(5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-indolin-1-yl)-2-(3-(trifluoromethyl)phenyl)ethanone. Grades: 98%. CAS No. 1337531-36-8. Molecular formula: C24H20F3N5O. Mole weight: 451.453. | |
| GSK-3787 | GSK-3787 is a potent and selective ligand for PPARdelta with good pharmacokinetic properties. Alternative Names: GSK-3787; GSK3787; GSK 3787. CAS No. 188591-46-0. Molecular formula: C15H12ClF3N2O3S. Mole weight: 392.78059. | |
| GSK-461364 | GSK-461364 is a Polo-like kinase 1 inhibitor, is also a small molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor GSK461364 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine / threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. Alternative Names: GSK461364; GSK 461364; GSK-461364; GSK461364A; GSK 461364A; GSK-461364A. 5-[6-[(4-Methyl-1-piperazinyl)methyl]-1h-benzimidazol-1-yl]-3-[(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide. CAS No. 929095-18-1. Molecular formula: C27H28F3N5O2S. Mole weight: 543.609. | |
| GSK525762 | GSK525762A, also known as I-BET-762 and GSK525762, is a small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins with potential antineoplastic activity. Upon administration, the BET inhibitor GSK525762 binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of bromodomain at the N-terminus, BET proteins, comprising of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during development and cellular growth. Alternative Names: GSK525762; GSK525762; GSK525762; GSK525762A; GSK-525762A; GSK 525762A; I-BET-762; I-BET762; I-BET 762; molibresib. CAS No. 1260907-17-2. Molecular formula: C22H22ClN5O2. Mole weight: 423.9. | |
| GSK547 | GSK547 is a highly selective and potent RIP1 (RIPK1) inhibitor which displays 400-fold improvement in mouse pharmacokinetic oral exposure compared with GSK963. Alternative Names: RIP1i. Grades: ≥98%. CAS No. 2226735-55-1. Molecular formula: C20H18F2N6O. Mole weight: 396.39. | |
| GSK583 | GSK583 is a selective receptor-interacting serine / threonine-protein kinase 2 (RIP2 Kinase) inhibitor and the RIP2K binding IC50 is 5 nM. GSK583 can inhibit both TNF-α and IL-6 production with an IC50 value of 200 nM in an ex vivo human translational model. Alternative Names: GSK583; GSK 583; GSK-583. 6 - (tert-Butylsulfonyl) - N - (5-fluoro - 1H - indazol-3-yl)quinolin-4-amine. Grades: 98%. CAS No. 1346547-00-9. Molecular formula: C20H19FN4O2S. Mole weight: 398.46. | |
| GSK-7975A | This active molecular is a calcium release-activated calcium modulator (ORAI1) inhibitor. GSK-7975A inhibited toxin-induced activation of ORAI1 and/or activation of Ca(2+) currents after Ca(2+) release in mouse and human pancreatic acinar cells. GSK-7975A may be used for the treatment of pancreatitis in the future. Uses: Pancreatitis. Alternative Names: GSK-7975A; GSK 7975A; GSK7975A; GSK-7975; GSK 7975; GSK7975. SCHEMBL705705; AOB4124; CPYTVBALBFSXSH-UHFFFAOYSA-N;2,6-difluoro-N-[1-[[4-hydroxy-2-(trifluoromethyl)phenyl]methyl]pyrazol-3-yl]benzamide. Grades: 98%. CAS No. 1253186-56-9. Molecular formula: C18H12F5N3O2. Mole weight: 397.31. | |
| GSK-8573 | GSK-8573 is an inactive control of GSK-2801, which is a potent inhibitor of BAZ2A and BAZ2B bromodomains. Alternative Names: GSK8573; GSK 8573; GSK-8573; 1-[1-(3-Methoxyphenyl)-7-propoxyindolizin-3-yl]ethanone. CAS No. 1693766-04-9. Molecular formula: C20H21NO3. Mole weight: 323.392. | |
| GSK-923295 | GSK-923295 is a novel antimitotic inhibitor of centromere-associated protein E (CENP-E) with potential anticancer activity. GSK-923295 demonstrated significant antitumor activity against solid tumor models, inducing CRs in Ewing sarcoma, rhabdoid, and rhabdomyosarcoma xenografts. Clinical study showed that GSK-923295 had dose-proportional pharmacokinetics and a low number of grade 3 or 4 adverse events. The observed incidence of myelosuppression and neuropathy was low. Further investigations may provide a more complete understanding of the potential for GSK-923295 as an antiproliferative agent. Alternative Names: GSK923295; GSK 923295; GSK-923295; GSK-923295A; GSK923295A; GSK 923295A. Grades: 98%. CAS No. 1088965-37-0. Molecular formula: C32H38ClN5O4. Mole weight: 592.14. | |
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