BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| ent-14β,16-Epoxy-8-pimarene-3β,15α-diol | ent-14,16-Epoxy-8-pimarene-3,15-diol isolated from the herbs of Siegesbeckia orientalis. Alternative Names: (3α,5β,10α,14α,15R)-14,16-Epoxypimar-8-ene-3,15-diol. Grades: 0.975. CAS No. 1188281-98-2. Molecular formula: C20H32O3. Mole weight: 320.5. |  |
| ent-16β,17-Dihydroxykauran-19-oic acid | ent-16β,17-Dihydroxykauran-19-oic acid isolated from the herbs of Xanthium sibiricum Patrin. Uses: Anti-hiv. Alternative Names: ent-16beta,17-Dihydroxy-19-kauraic acid; Diterpenoid SP-II. Grades: 0.98. CAS No. 3301-61-9. Molecular formula: C20H32O4. Mole weight: 336.5. | |
| ent-17-Hydroxykaura-9(11),15-dien-19-oic acid | ent-17-Hydroxykaura-9(11),15-dien-19-oic acid is extracted from the herbs of Wedelia trilobata. Alternative Names: ent-17-Hydroxykaura-9(11),15-dien-19-oic acid1588516-88-414-(hydroxymethyl)-5,9-dimethyltetracyclo[11.2.1.01,10.04,9]hexadeca-10,14-diene-5-carboxylic acid. Grades: 97.5%. CAS No. 1588516-88-4. Molecular formula: C20H28O3. Mole weight: 316.44. | |
| ent-3β-Hydroxykaur-16-en-19-oic acid | ent-3β-Hydroxykaur-16-en-19-oic acid is isolated from the herbs of Wedelia trilobata. Alternative Names: (3alpha,4alpha)-3-Hydroxykaur-16-en-18-oic acid;ent-3beta-Hydroxykaur-16-en-19-oic acid;Kaur-16-en-18-oic acid, 3-hydroxy-, (3α,4α)-;(3R,4S,4aS,6aS,9R,11aR,11bS)-3-hydroxy-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methanolocyclohepta[a]naphthalene-4-carboxylicaci;ent-3β-Hydroxykaur-16-en-19-oic acid. Grades: 97.5%. CAS No. 66556-91-0. Molecular formula: C20H30O3. Mole weight: 318.5. | |
| ent-3-Oxokauran-17-oic acid | ent-3-Oxokauran-17-oic acid is isolated from the herbs of Croton laevigatus. Alternative Names: 3-Oxokauran-17-oic acid; (5β,8α,9β,10α,13α,16β)-3-Oxokauran-17-oic acid. Grades: 98%. CAS No. 151561-88-5. Molecular formula: C20H30O3. Mole weight: 318.5. | |
| ent-6α,9α-Dihydroxy-15-oxokaur-16-en-19-oic acid β-D-glucopyranosyl ester | ent-6,9-Dihydroxy-15-oxokaur-16-en-19-oic acid β-D-glucopyranosyl ester is isolated from the herbs of Pteris semipinnata. Alternative Names: 1-O-[(5β,6β,8α,9β,10α,13α)-6,9-Dihydroxy-15,18-dioxokaur-16-en-18 -yl]-β-D-glucopyranose. Grades: 96.5%. CAS No. 81263-98-1. Molecular formula: C26H38O10. Mole weight: 510.6. | |
| ent-9-Hydroxy-15-oxokaur-16-en-19-oic acid β-D-glucopyranosyl ester | ent-9-Hydroxy-15-oxokaur-16-en-19-oic acid β-D-glucopyranosyl ester is a natural diterpenoid found in the herbs of Pteris semipinnata. Alternative Names: 1-O-[(5β,8α,9β,10α,13α)-9-Hydroxy-15,18-dioxokaur-16-en-18-yl]-β- D-glucopyranose. Grades: >97%. CAS No. 81263-96-9. Molecular formula: C26H38O9. Mole weight: 494.6. | |
| ent-9-Hydroxy-15-oxokauran-19-oic acid | Ent-9-Hydroxy-15-oxo-19-kauranoic acid is a natural diterpenoid found in the herbs of Pteris semipinnata. Alternative Names: (5β,8α,9β,10α,13α,16β)-9-Hydroxy-15-oxokauran-18-oic acid. Grades: >98%. CAS No. 77658-45-8. Molecular formula: C20H30O4. Mole weight: 334.5. | |
| Entacapone | Entacapone is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT) (IC50 = 151 nM), commonly used in combination with other medications for the treatment of Parkinson's disease. Alternative Names: 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2E)-; Comtan; HSDB 8251; HSDB-8251; HSDB8251; OR-611; OR 611; OR611; (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide; 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (E)-; (E)-Entacapone; Comtess; Entacom; Parkicapone. Grades: >98%. CAS No. 130929-57-6. Molecular formula: C14H15N3O5. Mole weight: 305.29. | |
| ent-Atisane-3β,16α,17-triol | ent-Atisane-3β,16α,17-triol, also called (3alpha,5beta,8alpha,9beta,10alpha,12alpha)-Atisane-3,16,17-triol is a natural compound. Alternative Names: (3alpha,5beta,8alpha,9beta,10alpha,12alpha)-Atisane-3,16,17-triol;ent-Atisane-3beta,16alpha,17-triol. Grades: >95%. CAS No. 115783-44-3. Molecular formula: C20H34O3. Mole weight: 322.48. | |
| ent-Cinacalcet | ent-Cinacalcet. CAS No. 694495-47-1. | |
| ent-Ezetimibe | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L3) protein, a cholesterol transporter located in the apical membrane of enterocytes. Alternative Names: R,S,R-Ezetimibe; (3S,4R)-1-(4-Fluorophenyl)-3-[(R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one; (3S,4R)-1-(4-Fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone; Ezetimibe (3S,4R,3'R)-Isomer; Ezetimibe (RSR)-Isomer; ent-SCH 58235; (3S,4R,3'R)-Ezetimibe. Grades: >95%. CAS No. 1376614-99-1. Molecular formula: C24H21F2NO3. Mole weight: 409.44. | |
| Entinostat | Entinostat is a histone deacetylase (HDAC) inhibitor displaying antiproliferative and antineoplastic effects. Entinostat induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), which slows cell growth, differentiation, and tumor development in vivo. Entinostat is potentially used as an antitumor drug in combination with other drugs like adriamycin, PARP inhibitors and Hsp90 inhibitors. Uses: Histone deacetylase inhibitors. Alternative Names: MS275; MS-275; MS 2275; SNDX275; SNDX-275; SNDX 275; Entinostat; pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate. Grades: > 98%. CAS No. 209783-80-2. Molecular formula: C21H20N4O3. Mole weight: 376.416. | |
| ent-Kaurane-2α,16β-diol | 2,16-Kauranediol is a natural diterpenoid found in the herbs of Pteris cretica. Alternative Names: 2,16-Kauranediol. Grades: >95%. CAS No. 34302-37-9. Molecular formula: C20H34O2. Mole weight: 306.5. | |
| ent-Kaurane-2α,6α,16β-triol | 2,6,16-Kauranetriol is a natural diterpenoid isolated from the herbs of Pteris cretica. Alternative Names: 2,6,16-Kauranetriol. Grades: >98%. CAS No. 41530-90-9. Molecular formula: C20H34O3. Mole weight: 322.5. | |
| ent-Kaurane-3β,16α,17-triol | ent-Kaurane-3β,16α,17-triol is isolated from the herbs of Croton laevigatus. Alternative Names: (3α,5β,8α,9β,10α,13α)-Kaurane-3,16,17-triol. Grades: > 95%. CAS No. 130855-22-0. Molecular formula: C20H34O3. Mole weight: 322.5. | |
| ent-Labda-8(17),13E-diene-3β,15,18-triol | Ent-Labda-8(17),13E-diene-3β,15,18-triol is extracted from the fronds of Dicranopteris linearis or D. ampla. Alternative Names: [1S-[1alpha,2beta,4abeta,5beta(E),8aalpha]]-Decahydro-2-hydroxy-5-(5-hydroxy-3-methyl-3-pentenyl)-1,4a-dimethyl-6-methylene-1-naphthalenemethanol; ent-Labda-8(17),13E-diene-3beta,15,18-triol; 1-(Hydroxymethyl)-5-(5-hydroxy-3-methylpent-3-enyl)-1,4a-dimethyl-6-methylidene-3,4,5,7,8,8a-hexahydro-2H-naphthalen-2-ol. Grades: 98.0%. CAS No. 90851-50-6. Molecular formula: C20H34O3. Mole weight: 322.48. | |
| ent-Labda-8(17),13Z-diene-15,16,19-triol 19-O-glucoside | ent-Labda-8(17),13Z-diene-15,16,19-triol 19-O-glucoside is isolated from the herbs of Andrographis paniculata. Alternative Names: 19-O-β-D-glucopyranosyl-ent-labda-8(17),13-dien-15,16,19-triol;ent-Labda-8(17),13Z-diene- 15,16,19-triol 19-O-glucoside;ENT-LABDA-8(17),13Z-DIENE-15,16;β-D-Glucopyranoside, [(1R,4aS,5R,8aS)-decahydro-5-[(3Z)-5-hydroxy-3-(hydroxymethyl)-3-penten-1-yl]-1,4a-dimethyl-6-methylene-1-naphthalenyl]methyl. Grades: 96%. CAS No. 1245636-01-4. Molecular formula: C26H44O8. Mole weight: 484.6. | |
| Entospletinib | Entospletinib (GS-9973) is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM. Phase 2. Alternative Names: GS9973; GS 9973; GS-9973. Grades: >98%. CAS No. 1229208-44-9. Molecular formula: C23H21N7O. Mole weight: 411.46. | |
| ent-Thiamphenicol-[d3] | ent-Thiamphenicol-[d3] is the labelled analogue of Thiamphenicol, which is an antimicrobial antibiotic. Alternative Names: ent-Thiamphenicol D3. CAS No. 1217723-41-5. Molecular formula: C12H12D3Cl2NO5S. Mole weight: 359.24. | |
| Enviroxime | Enviroxime is a benzimidazole derivative that inhibits the replication of rhinoviruses and poliovirus by targeting protein 3A. Enviroxime exhibits antiviral effects against EV71 with EC50 of 0.15 μM. Uses: Coxsackievirus infections; picornavirus infections. Alternative Names: ENVIROXIME;Viroxime;72301-79-2;Viroxime component B;63198-97-0;(NE)-N-[(2-amino-3-propan-2-ylsulfonylbenzimidazol-5-yl)-phenylmethylidene]hydroxylamine;NSC-346230;72301-78-1;LY-122772;(E)-2-Amino-6-benzoyl-1-(isopropylsulfonyl)benzimidazole oxime;LY 122771-72;NSC346230;LY 122772;2-Amino-1-(isopropylsulfonyl)-6-benzimidazole phenyl ketone oxime;1H-Benzimidazol-2-amine, 6-((hydroxyimino)phenylmethyl. Grades: 98%. CAS No. 72301-79-2. Molecular formula: C3H8OS2. Mole weight: 124.23. | |
| Enzastaurin | Enzastaurin is a protein kinase C beta inhibitor with 6- to 20-fold selectivity against PKCα, PKCγ and PKCε. Binding to the ATP-binding site, enzastaurin selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden. Alternative Names: 3-(1-Methyl-1H-indol-3-yl)-4-(1-(1-(pyridin-2-ylmethyl)piperidin-4-yl)-1H-indol-3-yl)-1H-pyrrole-2,5-dione; LY-317615. CAS No. 170364-57-5. Molecular formula: C32H29N5O2. Mole weight: 515.617. | |
| (E)-Olopatadine | (E)-Olopatadine is an isomer of Olopatadine, a histamine blocker and mast cell stabilizer. Alternative Names: Olopatadine, (E)-; Olopatadine (E)-Isomer. CAS No. 113806-06-7. Molecular formula: C21H23NO3. Mole weight: 337.4. | |
| (-)-Epiafzelechin | (-)-Epiafzelechin exhibits various modes of action in suppressing HSV-2 multiplication. Uses: Antioxidant; cyclooxygenase-1 inhibitor; anti-inflammatory. Alternative Names: epiafzelechin; epi-Afzelechin. Grades: > 95%. CAS No. 24808-04-6. Molecular formula: C15H14O5. Mole weight: 274.28. | |
| Epieriocalyxin A | Epieriocalyxin A (EpiA), a diterpenoid isolated from I. eriocalyx, suppressed Caco-2 colon cancer cell growth. Western blot results showed that both JNK and ERK1/2 activation was decreased after Epieriocalyxin A treatment in a dose-dependent manner. Epieriocalyxin A increased the expression of caspase 3 and Bax, and decreased Bcl2 expression. Our results suggest that Epieriocalyxin A is a novel compound that induces colon cancer apoptosis. Epieriocalyxin A could be a potential drug for colon cancer therapy in the future. Uses: Anti-cancer. Alternative Names: Spiro[1H-7,9a-methanolocyclohepta[c]pyran-4(3H),1'-[3]cyclohexene]-6'-carboxaldehyde, 4a,5,6,7,8,9-hexahydro-5',5',8-trimethyl-1,2',9-trioxo-, (1'S,4aS,6'R,7R,8R,9aS)-. Grades: >98%. CAS No. 191545-24-1. Molecular formula: C20H24O5. Mole weight: 344.4. | |
| Epigallocatechin 3-O-(3-O-Methyl)-Gallate | (-)-EGCG-3''-O-Me is a compound of the flavonoid class found in the leaves of Camellia sinensis. It exhibits antioxidative, antiallergic and anti-inflammatory effects. Alternative Names: Epigallocatechin 3-O-(3-O-methyl)gallate; [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4-dihydroxy-5-methoxybenzoate. Grades: >98%. CAS No. 83104-87-4. Molecular formula: C23H20O11. Mole weight: 472.402. | |
| (+)-Epigallocatechin gallate | (+)-Epigallocatechin gallate (EGCG) is a major bioactive catechin found in green tea, renowned for its potent antioxidant properties, which help neutralize free radicals and protect cells from oxidative damage. EGCG has been extensively studied for its potential health benefits, including anti-inflammatory, anticancer, and neuroprotective effects. It can inhibit the growth of cancer cells, reduce inflammation, and support cardiovascular health. Additionally, EGCG has shown promise in combating neurodegenerative diseases and viral infections. Alternative Names: Benzoic acid, 3,4,5-trihydroxy-, 3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester, (2S-cis)-; (+)-Epigallocatechin 3-gallate; Benzoic acid, 3,4,5-trihydroxy-, (2S,3S)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester; cis-5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate; ent-Epigallocatechin 3-gallate. Grades: ≥95%. CAS No. 137766-94-0. Molecular formula: C22H18O11. Mole weight: 458.37. | |
| Epiguajadial B | Epiguajadial B isolated from the herbs of Psidium guajava. Alternative Names: (5aR,7E,11E,14aS,15S)-rel-5a,6,9,10,13,14,14a,15-Octahydro-1,3-dihydroxy-5a,9,9,12-tetramethyl-15-phenylbenzo[b]cycloundeca[e]pyran-2,4-dicarboxaldehyde. Grades: > 95%. CAS No. 1411629-26-9. Molecular formula: C30H34O5. Mole weight: 474.6. | |
| Epinortrachelogenin | Epinortrachelogenin isolated from the barks of Cephalotaxus sinensis. Alternative Names: (3R-trans)-Dihydro-3-hydroxy-3,4-bis[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone. Grades: >=95%. CAS No. 125072-69-7. Molecular formula: C20H22O7. Mole weight: 374.4. | |
| (+)-Epipinoresinol | (+)-Epipinoresinol is isolated from the heartwood of Picea excelsa. Alternative Names: Pinoresinol. Grades: 98.0%. CAS No. 24404-50-0. Molecular formula: C20H22O6. Mole weight: 358.39. | |
| Epipodophyllotoxin acetate | Acetylepipodophyllotoxin isolated from the root of Dysosma versipellis (Hance) M.Cheng ex Ying. Uses: Highly antifeeding activity; toxic activity. Alternative Names: Acetylepipodophyllotoxin;epipodophyllotoxin acetate;1180-35-4;[(5S,5aR,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-5-yl] acetate;4-O-Epipodophyllotoxinyl acetate;DTXSID901019938;HY-N2812;AKOS032962448;FS-10195;CS-0023367. Grades: 98.5%. CAS No. 1180-35-4. Molecular formula: C24H24O9. Mole weight: 456.44. | |
| Eplerenone EP Impurity C | An impurity of Eplerenone. Eplerenone is a potassium-sparing diuretic that selectively blocks aldosterone activation of the mineralcorticoid receptor, demonstrating little activity towards other steroid receptors. Alternative Names: Δ9,11-7β-Eplerenone; (2'R,7R,8R,10S,13S,14S)-Methyl 10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,10,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate; (7a,17a)-17-Hydroxy-3-oxo-pregna-4,9(11)-diene-7,21-dicarboxylic acid g-lactone methyl ester. Grades: > 95%. CAS No. 95716-70-4. Molecular formula: C24H30O5. Mole weight: 398.50. | |
| Eprinomectin-[d3] | One of the isotope labelled form of Eprinomectin, which could be used as an antiparasitic agent. Alternative Names: (4''R)-4''-(Acetylamino)-5-O-demethyl-4''-deoxyavermectin A1a-d3 compound with (4''R)-4''-(Acetylamino)-5-O-demethyl-25-de(1-methylpropyl)-4''-deoxy-25-(1-methylethyl)avermectin A1a-d3. Molecular formula: C50D3H72NO14.C49D3H70NO14. Mole weight: 917.17 (B1a); 903.14 (B1b). | |
| EPZ011989 | EPZ011989 is a potent, orally-available EZH2 inhibitor with robust in vivo activity. EPZ011989 demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma. Alternative Names: EPZ011989; EPZ-011989; EPZ 011989. Grades: 98%. CAS No. 1598383-40-4. Molecular formula: C35H51N5O4. Mole weight: 605.82. | |
| EPZ015866 | EPZ015866,also called as GSK591, is a chemical probe for PRMT5 which has a role in diverse cellular processes including tumorigenesis. It exhibits excellent selectivity against a panel of methyltransferases. Inhibits the PRMT5/MEP50 complex from methylati. Alternative Names: GSK591; GSK-591; GSK 591; EPZ015866; EPZ-015866; EPZ 015866; GSK 3203591; GSK-3203591; GSK3203591; 2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyridine-4-carboxamideEPZ015866GSK591GTPL8954SCHEMBL16220740GSK32035912-(cyclobutylamino)-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyridine-4-carbo. CAS No. 1616391-87-7. Molecular formula: C22H28N4O2. Mole weight: 380.48. | |
| Erastin | Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i.e. HRAS, KRAS). Erastin produces non-apoptotic tumor cell death by altering mitochondrial voltage-dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death. Erastin blocks and reverses mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers. Reversal of tubulin-VDAC interaction by erastin antagonizes Warburg metabolism and restores oxidative mitochondrial metabolism. Alternative Names: Erastin. Grades: 0.98. CAS No. 571203-78-6. Molecular formula: C30H31ClN4O4. Mole weight: 547.04454. | |
| Ergocalciferol EP Impurity G | Vitamin D4 is a vitamin produced in fungi from the UV irradiation of 22,23-dihydroergosterol (Provitamin D4). Vitamin D4 is the active analogue of Vitamin D. Uses: Food additives. Alternative Names: Vitamin D4; 22,23-dihydroergocalciferol; 24S-Methylcalciol; 22,23-Dihydrovitamin D2; 9,10-Secoergosta-5(Z),7(E),10(19)-trien-3beta-ol. Grades: ≥98%. CAS No. 511-28-4. Molecular formula: C28H46O. Mole weight: 398.66. | |
| Eribulin | Eribulin suppressed centromere dynamics at concentrations that arrest mitosis. At 60 nmol/L eribulin (2 x mitotic IC(50)), the relaxation rate was suppressed 21%, the time spent paused increased 67%, and dynamicity decreased 35% (but without reduction in mean centromere separation), indicating that eribulin decreased normal microtubule-dependent spindle tension at the kinetochores, preventing the signal for mitotic checkpoint passage. [(3)H]eribulin binds soluble tubulin at a single site; however, this binding is complex with an overall K(d) of 46 microM, but also showing a real or apparent very high affinity (K(d) = 0.4 microM) for a subset of 25% of the tubulin. Eribulin also binds microtubules with a maximum stoichiometry of 14.7 +/- 1.3 molecules per microtubule (K(d) = 3.5 microM), strongly suggesting the presence of a relatively high-affinity binding site at microtubule ends. At 100 nM, the concentration that inhibits microtubule plus end growth by 50%, we found that one molecule of eribulin is bound per two microtubules, indicating that the binding of a single eribulin molecule at a microtubule end can potently inhibit its growth. Eribulin does not suppress dynamic instability at microtubule minus ends. Eribulin's in vivo superiority derives from its ability to induce irreversible mitotic blockade, which appears related to persistent drug retention and sustained Bcl-2 phosphorylation. Alternative Names: Halaven; B1939; E7 | |
| Eribulin Mesylate | Eribulin Mesylate is an antitumor drug that can be used to treat patients with metastatic breast cancer. It inhibits the proliferation of cancer cells by binding tubulin and microtubules. Eribulin Mesylate can inhibit experimental metastasis of breast cancer cells by reversing phenotype from epithelial-mesenchymal transition (EMT) to mesenchymal-epithelial transition (MET) states. Uses: The treatmnet of breast cancer. Alternative Names: 11,15:18,21:24,28-Triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-i]furo[2',3':5,6]pyrano[4,3-b][1,4]dioxacyclopentacosin-5(4H)-one, 2-[(2S)-3-amino-2-hydroxypropyl]hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)-, (2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-, methanesulfonate (1:1); 11,15:18,21:24,28-Triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-i]furo[2',3':5,6]pyrano[4,3-b][1,4]dioxacyclopentacosin-5(4H)-one, 2-[(2S)-3-amino-2-hydroxypropyl]hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)-, (2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-, methanesulfonate (salt); E 7389 methanesulfonate; Halaven; Eribulin monomethanesulfonate. Grades: ≥95%. CAS No. 441045-17-6. Molecular formula: C41H63NO14S. Mole weight: 826.01. | |
| Eriocalyxin B | Eriocalyxin B, isolated from the herbs of Isodon eriocalyx, is a potent NF-kappaB inhibitor. Eriocalyxin B inhibited the NF-kappaB transcriptional activity but not that of cAMP response element-binding protein. eriocalyxin B reversibly interfered with the binding of p65 and p50 subunits to the DNA in a noncompetitive manner. Eriocalyxin B exerts potent antiinflammatory effects through selective modulation of pathogenic Th1 and Th17 cells by targeting critical signaling pathways. Besides, Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways. Eriocalyxin B should be considered a candidate for pancreatic cancer treatment. Uses: Antiinflammatory. Alternative Names: Rabdosianone. Grades: >98%. CAS No. 84745-95-9. Molecular formula: C20H24O5. Mole weight: 344.4. | |
| Eriodictyol 7,3'-dimethyl ether | Eriodictyol 7,3'-dimethyl ether is a natural compound isolated from the herbs of Blumea balsamifera. Alternative Names: (2S)-5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-2,3-dihydrochromen-4-one. Grades: 98.0%. CAS No. 54352-60-2. Molecular formula: C17H16O6. Mole weight: 316.30. | |
| Erlotinib-[d6] Hydrochloride | Erlotinib-[d6] Hydrochloride is the labelled analogue of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Erlotinib is a medication used to treat non-small cell lung cancer and pancreatic cancer. Alternative Names: N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy-d3)-4-quinazolinamine Hydrochloride; 6,7-Bis(2-methoxyethoxy-d3)-4-(3-ethynylanilino)quinazoline Hydrochloride; [6,7-Bis(2-methoxyethoxy-d3)quinazolin-4-yl]-(3-ethynylphenyl)amine Hydrochloride; Erlotinib D6 Hydrochloride. Grades: 98% by CP; 98% atom D. CAS No. 1189953-78-3. Molecular formula: C22H18D6ClN3O4. Mole weight: 435.93. | |
| Erlotinib Impurity 8 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Alternative Names: N-(3-Desethynylphenyl)-N-(3-bromophenyl) Erlotinib; N-(3-bromophenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine. Grades: > 95%. CAS No. 328528-74-1. Molecular formula: C20H22BrN3O4. Mole weight: 448.32. | |
| Erlotinib O-Desmethyl Metabolite Isomer (M14) HCl | OSI-420 (CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells. Uses: For research used only. Alternative Names: OSI420; OSI-420; OSI 420; CP473420; CP-473420; CP 473420; Desmethyl Erlotinib. Grades: > 95%. CAS No. 183320-51-6. Molecular formula: C21H22ClN3O4. Mole weight: 415.874. | |
| Ertugliflozin | PF-04971729, a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2, is developed for the treatment of diabetes mellitus. Inhibitory effects against the organic cation transporter 2-mediated uptake of [14C]metformin by PF-04971729 is very weak (IC50 = 900μM). Uses: Sodium-glucose transporter 2 inhibitors. Alternative Names: PF-04971729; PF 04971729; PF04971729; PF-04971729-00; 1,6-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-(hydroxymethyl)-β-L-idopyranose; MK 8835; Steglatro; β-L-Idopyranose, 1,6-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-(hydroxymethyl)-; 1,6-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-(hydroxymethyl)-β-L-idopyranose; (1S,2S,3S,4R,5S)-5-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol. Grades: >98%. CAS No. 1210344-57-2. Molecular formula: C22H25ClO7. Mole weight: 436.88. | |
| Ervamycine | Ervamycine is a natural alkaloid isolated from the herbs of Melodinus khasianus. Alternative Names: 16-Methoxytabersonine. Grades: >96%. CAS No. 27773-39-3. Molecular formula: C22H26N2O3. Mole weight: 366.5. | |
| Erythrartine | Erythrartine is a natural alkaloid isolated from the bark of Erythrina variegata Linn. Alternative Names: (3α,11β)-3,15,16-Trimethoxy-1,2,6,7-tetradehydroerythrinan-11-ol. Grades: >97%. CAS No. 51666-26-3. Molecular formula: C19H23NO4. Mole weight: 329.4. | |
| Erythrinin C | Erythrinin C is a natural plant flavonoid isolated from the seeds of Psoralea corylifolia Linn. Alternative Names: 2-(1-Methyl-1-hydroxyethyl)-4-hydroxy-6-(4-hydroxyphenyl)-2,3-dihydro-5H-furo[3,2-g][1]benzopyran-5-one;2,3-Dihydro-2-(1-hydroxy-1-methylethyl)-4-hydroxy-6-(4-hydroxyphenyl)-5H-furo[3,2-g][1]benzopyran-5-one. Grades: >98%. CAS No. 63807-85-2. Molecular formula: C20H18O6. Mole weight: 354.4. | |
| (+)-Erythristemine | Erythristemine is a natural alkaloid found in the barks of Aralia chinensis. Alternative Names: 11-Methoxyerysotrine. Grades: >95%. CAS No. 28619-41-2. Molecular formula: C20H25NO4. Mole weight: 343.4. | |
| Erythromycin A iminoether | An impurity of Azithromycin. Azithromycin, derived from erythromycin, is an antibiotic. It binds to the 50S subunit of the bacterial ribosome, and thus inhibits translation of mRNA. It is an azalide, a subclass of macrolide antibiotics and is one of the world's best-selling antibiotics. Alternative Names: Erythromycin A 9,11-Imino Ether. Grades: > 95%. CAS No. 161193-44-8. Molecular formula: C37H66N2O12. Mole weight: 730.94. | |
| Erythromycin EP Impurity E | A decomposition product of the macrolide antibiotic, erythromycin A. Alternative Names: 8,9-anhydroerythromycin A 6,9-hemiketal; Erythromycin A enol ether. Grades: >98% by HPLC. CAS No. 33396-29-1. Molecular formula: C37H65NO12. Mole weight: 715.91. | |
| Escin Ia | Escin Ia is a triterpenoid saponin isolated from A. chinensis. It was shown to inhibit HIV-1 protease with IC50 value of 35 μM. Alternative Names: Aescin A; alpha-Escin. Grades: >98%. CAS No. 123748-68-5. Molecular formula: C55H86O24. Mole weight: 1131.3. | |
| Esculentic acid | Esculentic acid has been isolated from the roots of Phytolacca acinosa Roxb. It has protective effects against LPS-induced endotoxic shock. Esculentic acid is a selective COX-2 inhibitor and has anti-inflammatory effect. Uses: Anti-inflammatory effect. Alternative Names: (2α,3α)-2,3,23-Trihydroxyurs-12-en-28-oic acid. Grades: 95%. CAS No. 103974-74-9. Molecular formula: C30H48O5. Mole weight: 488.71. | |
| ESI-08 | ESI-08 is a potent and selective EPAC antagonist that completely inhibits both EPAC1 and EPAC2 activity (IC50 = 8.4 μM for EPAC2) without inhibition of cAMP-mediated PKA activation. Alternative Names: HJC-1-65; 4-Cyclohexyl-2-(2,5-dimethylbenzylthio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile. Grades: 99%. CAS No. 301177-43-5. Molecular formula: C20H23N3OS. Mole weight: 353.48. | |
| Esmolol Dimer | Esmolol Dimer is an impurity of Esmolol. Esmolol is a cardioselective β-blocker which has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. Alternative Names: 4-[2-hydroxy-3-[[3-[4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-1-oxopropyl](1-methylethyl)amino]propoxy]-benzenepropanoic Acid Methyl Ester. Grades: > 95%. CAS No. 98903-89-0. Molecular formula: C31H46N2O7. Mole weight: 558.7. | |
| Esmolol Impurity 1 | Esmolol Impurity 1 is an impurity of Esmolol. Esmolol is a cardioselective β-blocker which has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. Alternative Names: Methyl 3[4-(2,3-Epoxypropoxy)phenyl]propionate; 3-(4-(2,3-Epoxypropoxy)phenyl)propionic Acid Methyl Ester. Grades: >95%. CAS No. 81147-94-6. Molecular formula: C13H16O4. Mole weight: 236.26. | |
| Esomeprazole magnesium trihydrate | Esomeprazole magnesium trihydrate acts as a gastric proton pump inhibitor (PPI). In adults, esomeprazole is indicated for the treatment and maintenance of healing of erosive esophagitis, relieving of GERD symptoms; reduction of the risk for NSAID-associated gastric acid production. Alternative Names: Esomeprazole (Magnesium trihydrate); (S)-omeprazole magnesium trihydrate; Nexium; KS-1054; KS 1054; KS1054. Grades: ≥ 98%. CAS No. 217087-09-7. Molecular formula: C34H42MgN6O9S2. Mole weight: 767.17. | |
| Estra-1,3,5(10)-triene-3,17-diol,7-(9-bromononyl)-,17-acetate,(7a,17b)- | Estra-1,3,5(10)-triene-3,17-diol,7-(9-bromononyl)-,17-acetate,(7a,17b)- (CAS# 875573-66-3 ) is a useful research chemical. Alternative Names: (7a,17b)-7-(9-bromononyl)-estra-1,3,5(10)-triene-3,17-diol 17-acetate. Grades: 95 %. CAS No. 875573-66-3. Molecular formula: C29H43BrO3. Mole weight: 519.55. | |
| Estromustine | Estromustine is a metabolite of estramustine phosphate, an antineoplastic agent used for the treatment of prostate cancer. CAS No. 62899-40-5. Molecular formula: C23H29Cl2NO3. Mole weight: 438.39. | |
| Estrone | Estrone is one of the three naturally occurring estrogens, the others being estradiol and estriol. Estrone is synthesized from androstenedione by the aromatase enzyme system in the ovaries and placenta, and is also synthesized from estradiol by 17-hydroxy steroid dehydrogenase in the liver. Serum concentrations of estrone in premenopausal women fluctuate according to the menstral cycle and becomes the most predominant estrogen in postmenopausal women. The binding affinities of estrone to the estrogen receptors α and β are approximately 60% and 37% relative to estradiol. Alternative Names: 3-Hydroxyestra-1,3,5(10)-trien-17-one; (+)-Estrone; 1,3,5(10)-Estratrien-3-ol-17-one; 3-Hydroxy-17-keto-estra-1,3,5-triene; Aquacrine; Crinovaryl; Cristallovar; Crystogen; WAY 164397; Wynestron. Grades: 0.95. CAS No. 53-16-7. Molecular formula: C18H22O2. Mole weight: 270.372. | |
| Ethanol, 2-(2-ethoxyphenoxy)-, methanesulfonate | One of the impurities of Tamsulosin, which is an α1-adrenoceptor antagonist and could be used against benign prostatic hypertrophy. Alternative Names: 2-(2-ethyloxyphenoxy)ethyl methanesulfonate. CAS No. 169506-15-4. Molecular formula: C11H16O5S. Mole weight: 260.31. | |
| Ethaselen | Ethaselen, also known as BBSKE, is a novel organoselenium thioredoxin reductase inhibitor, is currently being investigated in a phase I clinical trial in China. Ethaselen enhanced the efficacy of radiation therapy both in vivo and in vitro without observable toxicity. BBSKE was found to suppress irradiation-induced activation dramatically when using A549 cells stably transfected with luciferase reporter. Ethaselen is a potentially promising agent for the treatment of patients with NSCLC clinically. Alternative Names: 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane; BBSKE. CAS No. 217798-39-5. Molecular formula: C16H12N2O2Se2. Mole weight: 422.199. | |
| Ethoxzolamide | Ethoxzolamide. CAS No. 452-35-7. | |
| Ethyl 1-(4-methoxyphenyl)-7a-morpholino-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-3a,4,5,6,7,7a-hexahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate | An impurity of Apixaban, a direct factor Xa inhibitor used as an anticoagulant for the prevention of venous thromboembolism and stroke in atrial fibrillation. CAS No. 1619934-76-7. Molecular formula: C31H37N5O6. Mole weight: 575.7. | |
| Ethyl 2-(4-butoxy-3-cyanophenyl)-4-methylthiazole-5-carboxylate | ethyl 2-(4-butoxy-3-cyanophenyl)-4-methylthiazole-5-carboxylate is an impurity of Febuxostat. Febuxostat is an antihyperuricemic nonpurine inhibitor of both the oxidized and reduced forms of xanthine oxidase. Alternative Names: ethyl 2-(3-formyl-4-isopropoxyphenyl)-4-methylthiazole-5-carboxylate. Grades: 98%. CAS No. 2230270-05-8. Molecular formula: C18H20N2O3S. Mole weight: 344.43. | |
| Ethyl 2,4-dihydroxy-6-pentylbenzoate | Ethyl 2,4-dihydroxy-6-pentylbenzoate, a component recognized for its potential in tackling oxidative stress-related illnesses, cancer, and inflammation, stands out for its anti-inflammatory, anti-tumor, and antioxidant capabilities. Pharmaceutical prospects are keen to explore its therapeutic potential, given its unique properties. Alternative Names: Ethyl Olivetolate; 2,4-Dihydroxy-6-pentyl-benzoic acid ethyl ester; Benzoic acid, 2,4-dihydroxy-6-pentyl-, ethyl ester. Grades: ≥95%. CAS No. 38862-65-6. Molecular formula: C14H20O4. Mole weight: 252.31. | |
| Ethyl 2,4-dihydroxyphenylacetate | Ethyl 2,4-dihydroxyphenylacetate isolated from the herbs of Diploclisia glaucescens. Alternative Names: Benzeneacetic acid, 2,4-dihydroxy-, ethyl ester. Grades: 97%. CAS No. 67828-62-0. Molecular formula: C10H12O4. Mole weight: 196.2. | |
| Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate | An impurity of Dovitinib, a potent VEGFR inhibitor exhibiting antitumor activity. Alternative Names: ethyl 2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate. CAS No. 402948-37-2. Molecular formula: C16H22N4O2. Mole weight: 302.37. | |
| Ethyl 2-bromothiophene-3-carboxylate | Ethyl 2-bromothiophene-3-carboxylate, a significant interstitial compound, is extensively utilized in the composition of drugs and pesticides. Its role as a fundamental precursor for anticancer, anti-inflammatory, and antifungal agents cannot be overstated. Furthermore, it is involved in the creation of state-of-the-art herbicides and insecticides, given its pivotal role in their synthesis. Alternative Names: 2-Bromo-3-thiophenecarboxylic acid ethyl ester. CAS No. 632325-50-9. Molecular formula: C7H7BrO2S. Mole weight: 235.1. | |
| Ethyl 2-chloro-2-[2-(2,4-dichlorophenyl)hydrazinylidene]acetate | Ethyl 2-chloro-2-[2-(2,4-dichlorophenyl)hydrazinylidene]acetate. CAS No. 27143-12-0. | |
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