MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Endosidin-2 | Endosidin-2 (ES2) is a selective inhibitor targeting the conserved exosome subunit EXO70. Endosidin-2 binds to the C-terminal domain of EXO70, inhibiting exocytosis and endosomal recycling, while promoting vacuolar trafficking in plant cells. Endosidin-2 interferes with the EXO70-mediated vesicle-to-plasma membrane anchoring process, leading to abnormal aggregation of auxin transporters (such as PIN2) in the cytoplasm and redirected to vacuolar degradation, while causing abnormal Golgi structure (such as cup-shaped or ring-shaped vesicles cisternae formation). Endosidin-2 can inhibit exocytosis in plant and mammalian cells and is mainly used to study the dynamic regulation of membrane trafficking (such as polar growth, vesicle sorting)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ES2. CAS No. 1839524-44-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120821. |  |
| Endosidine 5 | Endosidine 5 (ES5) inhibits EPS (extracellular polymeric substance) secretion and cell wall expansion. Endosidine 5 alters secretion of ECM (extracellular matrix) material in Penium margaritaceum by affecting the Golgi apparatus. Endosidine 5 interferes with recycling endosomes through Annexin A6, thereby promoting the release and expression of mRNA into the cytoplasm[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ES5. CAS No. 364361-68-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-159621. | |
| Endothall | Endothall (Endothal) is a protein phosphatase 2A (PP2A) inhibitor with IC50s of 90 nM and 5 μM for PP2A and PP1, respectively. Endothall can be used as an herbicide. Endothall also is useful in cancer chemotherapy[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Endothal. CAS No. 145-73-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-113976A. | |
| Endothelin-1 (1-31) (Human) | Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) is derived from the selective hydrolysis of big ET-1 by chymase[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 133972-52-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4159. | |
| Endothelin 1 (swine, human) | Endothelin 1 (swine, human) (ET-1) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB[1]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: ET-1 (swine, human). CAS No. 117399-94-7. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-P0202. | |
| Endothelin 1 (swine, human) TFA | Endothelin 1 (swine, human) (ET-1) TFA is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 TFA acts through two types of receptors ETA and ETB[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ET-1 (swine, human) TFA. CAS No. 394693-38-0. Pack Sizes: 500 μg; 5 mg; 10 mg. Product ID: HY-P0202A. | |
| Endothelin-3, human, mouse, rabbit, rat | Endothelin-3, human, mouse, rabbit, rat (Endothelin 3 (Rat,Human)) is an adhesion stimulant. Endothelin-3, human, mouse, rabbit, rat stimulates the adhesion of enteric neural crest cells to various ECM components. Endothelin-3, human, mouse, rabbit, rat plays an important role in the maintenance and self-renewal of intestinal progenitor cells, participates in the migration of enteric neural crest cells, and helps maintain a suitable environment for the colonization of enteric neural crest cells. Endothelin-3, human, mouse, rabbit, rat acts synergistically with the β1-integrin signaling pathway during enteric nervous system development. Endothelin-3, human, mouse, rabbit, rat can be used in studies related to distal aganglionosis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Endothelin 3 (Rat,Human). CAS No. 117399-93-6. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-P0204. | |
| Endoxifen | Endoxifen is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen has the potential for breast cancer study[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 110025-28-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18719E. | |
| Endoxifen (Z-isomer) | Endoxifen Z-isomer hydrochloride, an orally active Tamoxifen (HY-13757A) metabolite, is a selective estrogen receptor modulator with 100-fold more potency than its parent agent, Tamoxifen. Endoxifen Z-isomer inhibits PKCβ1 kinase activity. Endoxifen Z-isomer attenuates PKCβ1-activated AKTSer473 phosphorylation, diminishes AKT substrate phosphorylation, and induces Apoptosis. Endoxifen Z-isomer exhibits anticancer activity against hormone-resistant metastatic breast cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 112093-28-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-18719. | |
| Endoxifen Z-isomer hydrochloride | Endoxifen Z-isomer hydrochloride, an orally active Tamoxifen (HY-13757A) metabolite, is a selective estrogen receptor modulator with 100-fold more potency than its parent agent, Tamoxifen. Endoxifen Z-isomer hydrochloride inhibits PKCβ1 kinase activity. Endoxifen Z-isomer hydrochloride attenuates PKCβ1-activated AKTSer473 phosphorylation, diminishes AKT substrate phosphorylation, and induces Apoptosis. Endoxifen Z-isomer hydrochloride exhibits anticancer activity against hormone-resistant metastatic breast cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1032008-74-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-18719A. | |
| Enduracidin | Enduracidin (Enramycin) is a polypeptide antibiotic produced by Streptomyces fungicides[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Enramycin. CAS No. 11115-82-5. Pack Sizes: 100 mg; 500 mg. Product ID: HY-131093. | |
| Enflicoxib | Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2).?Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: E 6087. CAS No. 251442-94-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19384. | |
| Enfortumab | Enfortumab is a humanized derived anti-Nectin-4 antibody that can be conjugated with the highly efficient microtubule disruptor MMAE (HY-15162) to generate the antibody drug conjugate (ADC) Enfortumab vedotin-ejfv (HY-P99016A). Enfortumab can be used for the study of locally advanced and metastatic urothelial carcinoma[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1448664-46-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P99016. | |
| Enfortumab vedotin-ejfv | Enfortumab vedotin-ejfv is an anti-Nectin-4 antibody-drug conjugate. Enfortumab vedotin-ejfv is a fully humanized IgG1 antibody conjugated to the microtubule disrupting agent MMAE (HY-15162) via a protease-cleavable Val-Cit linker. The antibody portion is Enfortumab (HY-P99016), and the drug-linker conjugate for ADC is VcMMAE (HY-15575). Nectin-4 is an adhesion protein involved in cellular processes and tumorigenesis, and Enfortumab vedotin-ejfv is indicated for the inhibition of locally advanced or metastatic urothelial carcinoma[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1346452-25-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99016A. | |
| Enfortumab vedotin-ejfv (solution) | Enfortumab vedotin-ejfv (solution) is an anti-Nectin-4 antibody-drug conjugate (ADC). Enfortumab vedotin-ejfv (solution) is a fully humanized IgG1 antibody conjugated to the microtubule disrupting agent MMAE (HY-15162) via a protease-cleavable Val-Cit linker. The antibody portion is Enfortumab (HY-P99016), and the drug-linker conjugate for ADC is VcMMAE (HY-15575). Nectin-4 is an adhesion protein involved in cellular processes and tumorigenesis, and Enfortumab vedotin-ejfv (solution) is indicated for the inhibition of locally advanced or metastatic urothelial carcinoma[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1346452-25-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P99016B. | |
| Enfumafungin | Enfumafungin, a triterpene glycoside, is isolated from extracts derived from fungus Hormonema carpetanum. Enfumafungin is an antifungal compound that is acting on the fungal cell wall, as the (1,3)-beta-D-glucan synthase inhibitor. Enfumafungin is specific for yeasts and fungi (excluding Cryptococcus) and does not inhibit the growth of Bacillus subtilis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 260979-95-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N8537. | |
| Enfuvirtide | Enfuvirtide (T20;DP178) is an anti-HIV-1 fusion inhibitor peptide. Uses: Scientific research. Category: Signaling pathways. Alternative Names: T20; DP178. CAS No. 159519-65-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P0052. | |
| Engasertib | Engasertib is an orally active highly specific AKT inhibitor with IC50 values of 0.13 μM, 0.09 μM and 2.75 μM for AKT1, AKT2 and AKT3, respectively. Engasertib inhibits AKT phosphorylation and modulates downstream signalling in vitro. Engasertib can inhibit cancer cell proliferation and tumor growth[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALM301. CAS No. 1313439-71-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151504. | |
| Engeletin | Engeletin is a flavanonol glycoside isolated from Smilax glabra Roxb. , inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects. Uses: Scientific research. Category: Signaling pathways. CAS No. 572-31-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0436. | |
| Englerin A | Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC50s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca2+ influx and Ca2+ cell overload[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1094250-15-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-133168. | |
| Englumafusp alfa | Englumafusp alfa (CD19-4-1BBL; RO7227166) is a fusion construct comprised of a CD19-specific antibody domain fused to a trimerized extracellular domains of human 41BBL. Englumafusp alfa promotes CD19-specific 4-1BB cross-linking on the surface of T and NK cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CD19-4-1BBL; RO7227166; RG6076. CAS No. 2417199-08-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990017. | |
| Enhanced Green Fluorescent Protein (EGFP) (200-208) | Enhanced Green Fluorescent Protein (EGFP) (200-208) is a marker gene product derived from the jellyfish Aequorea Victoria. Enhanced Green Fluorescent Protein (EGFP) (200-208) is a common reporter protein and is easy to detect[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 323198-39-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2528. | |
| Enitociclib | Enitociclib ((+)-BAY-1251152; (+)-VIP152) is a selective CDK9 inhibitor (IC50=3 nM) that inhibits transcriptional elongation by blocking Ser2/Ser5 phosphorylation of RNA polymerase II. Enitociclib specifically depletes key short-lived proteins such as c-MYC, MCL-1 and induces tumor cell apoptosis. Enitociclib also interferes with the production of enhancer RNAs (eRNA) and enhancer-promoter interactions, and downregulates oncogene expression at the epigenetic level. Enitociclib exerts synergistic effects with agents including Bortezomib (HY-10227), Lenalidomide (HY-A0003), Pomalidomide (HY-10984), Venetoclax (HY-15531) and Paclitaxel (HY-B0015), and even reverses paclitaxel resistance. Enitociclib serves as a vital research tool for various malignancies such as double-hit diffuse large B-cell lymphoma, multiple myeloma and pancreatic ductal adenocarcinoma[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-BAY-1251152; (+)-VIP152; (S)-Enitociclib. CAS No. 1610408-97-3. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103019. | |
| (±)-Enitociclib | (±)-Enitociclib ((±)-BAY-1251152) is the racemic mixture of Enitociclib (HY-103019E). Enitociclib is a selective CDK9 inhibitor and apoptosis inducer. Enitociclib inhibits CDK9 activity and reduces the phosphorylation of Ser2 in the carboxyl-terminal domain (CTD) of RNA polymerase Pol II, thereby downregulating the transcription of key oncogenes such as MYC and MCL1. Enitociclib has anti-proliferative activity targeting MYC+ lymphoma and multiple myeloma (MM) cells, and has synergistic effects with Bortezomib (HY-10227) and Lenalidomide (HY-A0003), and can be used in the research of hematological malignancies[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (±)-BAY-1251152; (±)-VIP152. CAS No. 1610358-53-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-103019A. | |
| Enlicitide chloride | Enlicitide chloride is an orally active inhibitor for PCSK9 that blocks the interaction between LPL receptor and PSCK9, with an IC50 of 2.5 nM. Enlicitide chloride can be used in the study of cardiovascular diseases such as atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome or related cardiovascular and cardiometabolic disorders[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-0616 chloride. CAS No. 2407527-16-4. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-P4153. | |
| Enlimomab | Enlimomab (BI-RR 0001), a murine IgG2a monoclonal antibody to the human ICAM-1, inhibits leukocyte adhesion to the vascular endothelium, thereby decreasing leukocyte extravasation and inflammatory tissue injury. Enlimomab has anti-inflammatory effects, and can be used for stroke research[1] [2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BI-RR 0001; Anti-Human IL6 Recombinant Antibody. CAS No. 142864-19-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99336. | |
| ENMD-1068 hydrochloride | ENMD-1068 hydrochloride is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 hydrochloride reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 hydrochloride also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 hydrochloride can be used in the study of endometriosis and liver fibrosis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2703451-51-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-124748A. | |
| ENMD-2076 | ENMD-2076 is a multi-targeted kinase inhibitor with IC50s of 1.86, 14, 58.2, 15.9, 92.7, 70.8, 56.4 nM for Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 934353-76-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10987A. | |
| Enmein | Enmein is isolated from I. serra with immunosuppressive effect[1]. Uses: Scientific research. Category: Natural products. CAS No. 3776-39-4. Pack Sizes: 1 mg. Product ID: HY-N5028. | |
| Enmetazobactam | Enmetazobactam (AAI101) is an extended-spectrum β-lactamase inhibitor, against many resistant Gram-negative pathogens[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AAI101. CAS No. 1001404-83-6. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-103095. | |
| Enniatin B1 | Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes[1]. Enniatin B1 crosss the blood-brain barrier[2]. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 19914-20-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N3807. | |
| Enoblituzumab | Enoblituzumab (MGA271) is a humanized IgG1κ monoclonal antibody recognizing human B7-H3 protein, a member of the B7 family of immune regulators[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MGA271. CAS No. 1353485-38-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9966. | |
| Enokizumab | Enokizumab (MEDI-528) is a monoclonal antibody targeting to interleukin (IL)-9. IL-9 regulates the development of airway inflammation, mucus production, airway hyperresponsiveness, and airway fibrosis largely by increasing mast cell numbers and activity in the airways[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MEDI-528. CAS No. 909875-08-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99193. | |
| Enoticumab | Enoticumab (REGN421, SAR153192) is an IgG1κ antibody targeting human Dll4. DLL4 is a ligand of the Notch signaling pathway and regulates fatty acid uptake through non-transcriptional regulation of macropinocytosis-dependent long-chain fatty acid uptake. Specific in vivo activity of Enoticumab in an ovarian xenograft model. EGN421 (2.5 mg/kg once weekly) resulted in 86% and 83% tumor growth inhibition in mouse subcutaneous TOV-112D or intraperitoneal A2780 human tumor xenograft models, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: REGN421. CAS No. 1192578-27-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99925. | |
| Enoxaparin | Enoxaparin (PK 10169), a low-molecular-weight heparin (LMWH) derivative. Enoxaparin exerts anticoagulant activity through antithrombin III, an endogenous inhibitor of factor Xa and thrombin IIa. Enoxaparin protect the rat hippocampus against TBI (traumatic brain injury) via antioxidant and anti-inflammatory properties. Enoxaparin can be used for the research of deep vein thrombosis (DVT), pulmonary embolism, TBI and COVID-19[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PK 10169; Enoxaparin sodium. CAS No. 679809-58-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109509. | |
| Enoximone | Enoximone is an inotropic vasodilating agent and a selective and orally active phosphodiesterase III (PDE3) inhibitor with an IC50 of 5.9 μM. Enoximone induces vasodilatation and increases intracellular levels of cAMP by inhibiting cGMP-inhibited PDE. Enoximone also exhibits PDE4 inhibitory effect with an IC50 of 21.1 μM for myocardial PDE4A. Enoximone has the potential for congestive heart failure research and has bronchodilatory, antiasthma and anti-inflammatory effects[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 77671-31-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-B1639. | |
| Enpatoran | Enpatoran (M5049) is a potent, orally active and dual TLR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran is inactive against TLR3, TLR4 and TLR9. Enpatoran can block molecule synthetic ligands and natural endogenous RNA ligands. Enpatoran exhibits excellent pharmacokinetic properties in vivo. Enpatoran can be used for both innate and adaptive autoimmunity blocking research [1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: M5049. CAS No. 2101938-42-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-134581. | |
| Enpatoran hydrochloride | Enpatoran (M5049) hydrochloride is a potent, orally active and dual TLR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran hydrochloride is inactive against TLR3, TLR4 and TLR9. Enpatoran hydrochloride can block molecule synthetic ligands and natural endogenous RNA ligands. Enpatoran hydrochloride exhibits excellent pharmacokinetic properties in vivo. Enpatoran hydrochloride can be used for both innate and adaptive autoimmunity blocking research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: M5049 hydrochloride. CAS No. 2101945-93-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-134581A. | |
| Enpp-1-IN-1 | Enpp-1-IN-1 is an effective selective enpp-1 (nucleotide pyrophosphatase-phosphodiesterase 1) inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2289728-58-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129490. | |
| Enpp-1-IN-14 | Enpp-1-IN-14 (Compound 015) is a potent Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) inhibitor with an IC50 value of 32.38 nM for recombinant human ENPP-1. Enpp-1-IN-14 has anti-tumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2687222-59-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147389. | |
| Enpp-1-IN-2 | Enpp-1-IN-2 (Compound C) is a potent ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) inhibitor with IC50 values of 0.26, 0.48 and 2.0 μM evaluated by means of TG-mAMP, pNP-TMP, and ATP assays, respectively. TG (Tokyo Green)-mAMP: a newly synthesized sensitive ENPP1 fluorescence probe[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2378640-92-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139362. | |
| ENPP3 Inhibitor 1 | ENPP3 Inhibitor 1 is a selective inhibitor of ENPP3, with IC50s of 0.15 μM (ENPP3) and 41.4 μM (ENPP1) respectively. ENPP3 Inhibitor 1 shows anti-tumor activities against breast cancer and cervical cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2803505-90-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-169804. | |
| Enristomig | Enristomig (ES-101) is a multispecific antibody. Enristomig is both a PD-L1 antagonist and a conditional agonist of 4-1BB. Enristomig can be used for research on PD-L1 expressing tumors[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ES-101; INBRX-105. CAS No. 2539845-73-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P990738. | |
| Enrofloxacin | Enrofloxacin (BAY Vp 2674) is an effective antibiotic with an MIC90 of 0.312 μg/mL for Mycoplasma bovis. Uses: Scientific research. Category: Induced disease models products. Alternative Names: BAY Vp 2674; PD160788. CAS No. 93106-60-6. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g; 10 g. Product ID: HY-B0502. | |
| Enrofloxacin monohydrochloride | Enrofloxacin monohydrochloride (BAY Vp 2674 monohydrochloride) is an effective antibiotic with an MIC90 of 0.312 μg/mL for Mycoplasma bovis. Enrofloxacin monohydrochloride shows inhibitory activity against vaccinia virus (VV). Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY Vp 2674 monohydrochloride; PD160788 monohydrochloride. CAS No. 93106-59-3. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 5 g; 10 g. Product ID: HY-B0502A. | |
| Ensartinib | Ensartinib (X-396) is a BBB-permeable and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: X-396. CAS No. 1370651-20-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103714. | |
| Ensartinib dihydrochloride | Ensartinib dihydrochloride (X-396 dihydrochloride) is a BBB-permeable and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: X-396 dihydrochloride. CAS No. 2137030-98-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103714A. | |
| Ensifentrine | Ensifentrine (RPL-554) is an inhaled dual inhibitor of PDE3 and PDE4 with IC50s of 0.4 nM and 1479 nM, respectively. Ensifentrine blocks PDE3 and PDE4 enzymes, thereby increasing the levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in lung cells, dilating the bronchi, and inhibiting the activation and migration of inflammatory cells. Ensifentrine can be used in the research of chronic obstructive pulmonary disease (COPD)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RPL-554. CAS No. 1884461-72-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119708. | |
| Ensitrelvir | Ensitrelvir (S-217622) is the first orally active non-covalent, non-peptidic, SARS-CoV-2 3CL protease inhibitor (IC50=13 nM)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S-217622. CAS No. 2647530-73-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143216. | |
| Entacapone | Entacapone is a potent, reversible, peripherally acting and orally active catechol-O-methyltransferase (COMT) inhibitor. Entacapone inhibits COMT from rat brain, erythrocytes and liver with IC50 values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone is selective for COMT over other catecholamine metabolizing enzymes, including MAO-A, MAO-B, phenolsulphotransferase M (PST-M) and PST-P (IC50s>50 μM). Entacapone can be used for the research of Parkinson's disease[1]. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 130929-57-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14280. | |
| Entadamide A | Entadamide A (compound 1) is a tryptophan derivative. Entadamide A prevents tryptophan depletion by inhibiting indoleamine 2, 3-dioxygenase (IDO), thereby inhibiting HIV replication. Entadamide A can be used in drug and neuropsychiatric studies of redesivir [1]. Uses: Scientific research. Category: Natural products. CAS No. 100477-88-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N12125. | |
| Entecavir | Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS200475; SQ34676. CAS No. 142217-69-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13623. | |
| Entecavir monohydrate | Entecavir monohydrate (BMS200475 monohydrate; SQ34676 monohydrate) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS200475 monohydrate; SQ34676 monohydrate. CAS No. 209216-23-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13623A. | |
| Enterobactin | Enterobactin is a siderophore produced by Gram-negative bacteria and has an extremely high affinity for iron. During the process of Salmonella typhimurium infecting macrophages, Enterobactin can not only help bacteria uptake iron but also reduce the antibacterial activity of macrophages. In addition, Enterobactin is also involved in the oxidative stress response of Escherichia coli. Enterobactin can be hydrolyzed by Fes in the cell and exert antioxidant effects by scavenging free radicals[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 28384-96-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128525. | |
| Enterocin K1 | Enterocin K1 (EntK1) is a bacteriocin. Enterocin K1 is a ribosomal synthetic peptide. Enterocin K1 specifically targets Enterococcus faecalis via the Eep protein on the bacterial membrane. Enterocin K1 displays a potent antibacterial activity against VRE. Enterocin K1 can be used for related studies of VRE infections[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EntK1. CAS No. 2764845-22-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P5203. | |
| Enterolactone | Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity[1]. Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 78473-71-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-108692. | |
| Entinostat | Entinostat is an oral and selective class I HDAC inhibitor, with IC50s of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MS-275; SNDX-275. CAS No. 209783-80-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-12163. | |
| Entospletinib | Entospletinib (GS-9973) is an orally bioavailable, selective Syk inhibitor with an IC50 of 7.7 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GS-9973. CAS No. 1229208-44-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15968. | |
| Entrectinib | Entrectinib (NMS-E628) is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC50 values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NMS-E628; RXDX-101. CAS No. 1108743-60-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12678. | |
| Entrectinib (Standard) | Entrectinib (Standard) is the analytical standard of Entrectinib. This product is intended for research and analytical applications. Entrectinib (NMS-E628) is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC50 values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NMS-E628 (Standard); RXDX-101 (Standard). CAS No. 1108743-60-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12678R. | |
| Ent-(+)-Verticilide | ent-(+)-verticilide is a potent and selective inhibitor of cardiac ryanodine receptor (RyR2) calcium release channels with antiarrhythmic activity. ent-(+)-verticilide inhibits RyR2-mediated diastolic Ca2+ leak and exhibits higher potency and a distinct mechanism of action compared with theDantrolene and Tetracaine. ent-(+)-verticilide is a useful tool to investigate the therapeutic potential of targeting RyR2 hyperactivity in heart and brain pathologies[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2056011-05-1. Pack Sizes: 100 μg; 500 μg; 1 mg; 5 mg. Product ID: HY-N7491A. | |
| Envafolimab | Envafolimab (ASC 22; KN 035) is a recombinant protein of a humanized single-domain anti- PD-L1 antibody. Envafolimab is created by a fusion of the of anti-PD-L1 domain with Fc fragment of human IgG1 antibody. Envafolimab blocks interaction between PD-L1 and PD-1 with an IC50 value of 5.25 nM. Envafolimab has the potential for the research of solid tumors[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ASC 22; KN 035. CAS No. 2102192-68-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99115. | |
| Envudeucitinibum | Envudeucitinibum (Envudeucitinib) is a highly selective, allosteric and orally active TYK2 inhibitor binding to the JH2 domain of TYK2. Envudeucitinibum has no off-target effects on other kinases (JAK1-3). Envudeucitinibum reduces signaling and production of proinflammatory cytokines including IL-12, IL-23, IL-17, and type I interferons (IFNs). Envudeucitinibum can be used for the research of plaque psoriasis, systemic lupus erythematosus (SLE), and other immune-mediated diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Envudeucitinib; ESK-001. CAS No. 2417135-66-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-153701S. | |
| Enzalutamide | Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells. Enzalutamide is an autophagy activator[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MDV3100. CAS No. 915087-33-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 2 g; 5 g. Product ID: HY-70002. | |
| Enzalutamide carboxylic acid | Enzalutamide carboxylic acid (MDV3100 carboxylic acid) is an inactive metabolite of Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MDV3100 carboxylic acid. CAS No. 1242137-15-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-70002B. | |
| Enzalutamide-d6 | Enzalutamide-d6 (MDV3100-d6) is a deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MDV3100-d6. CAS No. 1443331-94-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-70002S1. | |
| Enzastaurin | Enzastaurin (LY317615) is a potent, selective, and CNS-penetrant PKCβ inhibitor with an IC50 of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY317615. CAS No. 170364-57-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10342. | |
| Enzomenib | Enzomenib (DSP-5336) is an orally active Menin inhibitor (IC50=1.4 nM, Kd=6.0 nM). Enzomenib disrupts the interaction between Menin and KMT2A/MLL fusion proteins, specifically inhibits the expression of leukemia driver genes such as HOX/MEIS1, and upregulates ITGAM. Enzomenib effectively induces cell differentiation, inhibits tumor cell proliferation, and suppresses primitive cell colony formation. Enzomenib reduces disease burden and prolongs survival, but causes adverse reactions including differentiation syndrome and QTc interval prolongation. Enzomenib is used for research on relapsed/refractory acute myeloid leukemia, acute lymphoblastic leukemia, and other hematologic malignancies with mixed lineage leukemia (MLL) rearrangements or NPM1 mutations[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DSP-5336. CAS No. 2412555-70-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156794. | |
| EOAI3402143 | EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits Usp9x/Usp24 and Usp5. Uses: Scientific research. Category: Signaling pathways. CAS No. 1699750-95-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111408. | |
| (E)-Octinoxate-13C,d3 | (E)-Octinoxate-13C,d3 is the 13C- and deuterium labeled (E)-Octinoxate[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2734919-82-3. Pack Sizes: 1 mg. Product ID: HY-B1234AS. | |
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