MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Famprofazone | Famprofazone is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the pyrazolone series, and it has analgesic, anti-inflammatory, and antipyretic effects. Uses: Scientific research. Category: Signaling pathways. CAS No. 22881-35-2. Pack Sizes: 100 mg; 500 mg. Product ID: HY-B1054. |  |
| Fanapanel | Fanapanel (ZK200775) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ZK200775; MPQX. CAS No. 161605-73-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15069. | |
| FANCM-BTR PPI-IN-1 | FANCM-BTR PPI-IN-1 (Compound 32) is a FANCM/BTR interaction inhibitor that blocks the localization of FANCM to telomeres. FANCM-BTR PPI-IN-1 exhibits anticancer activity against osteosarcoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3033990-61-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-163573. | |
| Fangchinoline | Fangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel HIV-1 inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing[1]. Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK[2]. Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 436-77-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N1372A. | |
| FAPI-34 | FAPI-34 is a SPECT imaging agent targeting FAP. FAPI-34 specifically binds to FAP, is highly internalized by FAP-expressing cells, accumulates in FAP-expressing tumor lesions, and shows low uptake in normal tissues except the kidneys. FAPI-34 is applicable for tumor-related research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2374782-07-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-139401. | |
| FAPI-4 | FAPI-4 is a potent fibroblast activation protein (FAP) inhibitor for the targeting FAP. FAPI-4 can be used in cancer research. 68Ga-FAPI-4 PET/CT is a promising new diagnostic method for imaging various kinds of cancer, with good tumor-to-background contrast ratios[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2374782-02-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-128643. | |
| FAPI-46 | FAPI-46 is a quinoline-based fibroblast activation protein (FAP)-targeted tracer. Use radioactivity FAPI-46 labeled with 68Ga or 177Lu can be used for tumor imaging in a variety of cancers and has higher tumor uptake rates and longer tumor accumulation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2374782-04-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137331. | |
| FAPI-74 | FAPI-74 is a PET (positron emission tomography) tracer targeting the fibroblast activation protein (FAP). FAPI-74 can be used for FAP-positive tumor research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2374782-76-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147173. | |
| FAPI-mFS | FAPI-mFS is an irreversible fibroblast activation protein (FAP) inhibitor, that enhances the uptake and retention time in cancer cells through its covalent binding property for FAP. FAPI-mFS can be used for cancer imaging the therapy, when labeled with radioactive 68Ga or 177Lu[1]. FAPI-mFS can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). Uses: Scientific research. Category: Signaling pathways. CAS No. 3023869-94-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-164725. | |
| FAP targeting peptide for FXX489 | FAP targeting peptide for FXX489 is the polypeptide part of Unlabeled FXX489 (HY-P10944). Unlabeled FXX489 is a fibroblast activation protein (FAP)-targeting ligand[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3076328-74-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P10945. | |
| Farabursen | Farabursen (RGLS8429; RG1015) is a blood-brain barrier-permeable miR-17 inhibitor. Farabursen derepresses Pkd1 and Pkd2, the target genes of miR-17, increases the levels of PC1 and PC2, and reduces cyst growth. Farabursen decreases renal cyst growth, kidney weight-to-body weight ratio, cyst index, proliferation index, and blood urea nitrogen levels in mouse models. Farabursen is applicable to research related to autosomal dominant polycystic kidney disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RGLS8429; RG1015. CAS No. 2953012-32-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-150364. | |
| Farabursen sodium | Farabursen sodium (RGLS8429 sodium; RG1015 sodium) is a miR-17 inhibitor. Farabursen sodium inhibits the function of the miR-17 family, relieves the inhibitory effect on miR-17 target genes including PKD1 and PKD2, and increases the level of PC1/2. Farabursen sodium slows the growth of renal cysts, reduces the ratio of kidney weight to body weight, and decreases the cyst index and proliferation index. Farabursen sodium is applicable to research related to autosomal dominant polycystic kidney disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RGLS8429 sodium; RG1015 sodium. CAS No. 2921918-19-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-150364A. | |
| Faralimomab | Faralimomab (64G12) is an immunomodulator, and a murine anti-IFNA1 IgG1 mAb[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 64G12. CAS No. 167816-91-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99611. | |
| Faricimab | Faricimab, an overall good safety and tolerability profile, is a bispecific antibody targeting Angiopoietin-2 (Ang-2) and vascular endothelial growth factor-A (VEGF-A). Faricimab prevents retinal vascular leakage, cell death and inflammation in retinal ischemia/reperfusion (I/R) injury and sCNV mouse models. Faricimab demonstrates statistically superior visual acuity gains versus Ranibizumab (HY-P9951). Faricimab can be used for retinal diseases, such as age-related macular degeneration (w-AMD), diabetic macular edema (DME) and macular edema following retinal vein occlusion (RVO)[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RG7716; RO-6867461. CAS No. 1607793-29-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99116. | |
| Farletuzumab | Farletuzumab (MORAb-003) is a potent folate receptor-alpha (FRα) inhibitor. Farletuzumab is a humanized monoclonal antibody with high affinity for FRα. Farletuzumab possesses growth-inhibitory functions on cells overexpressing FRα. Farletuzumab can be used in research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MORAb-003. CAS No. 896723-44-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99153. | |
| Farnesene (mixture of isomers) | Farnesene (mixture of isomers) is a farnesene with mixture of isomers. Farnesene is a herbivore-induced plant volatile (HIPV). Farnesene has an important effect on insect resistance in many plant species[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 125037-13-0. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg. Product ID: HY-14620A. | |
| Farnesol | Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans, and has the activity in inhibiting bacteria. Uses: Scientific research. Category: Induced disease models products. CAS No. 4602-84-0. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-Y0248A. | |
| Farnesyl pyrophosphate ammonium | Farnesyl pyrophosphate (Farnesyl diphosphate) ammonium is a metabolic intermediate in the mevalonate (MVA) pathway. It is a TRP channel (TRPM2) agonist that triggers Ca2+ influx and cell death. Farnesyl pyrophosphate ammonium is a key branch substrate for cholesterol synthesis, ubiquinone synthesis, protein farnesylation, and geranylgeranyl pyrophosphate (GGPP) synthesis. Farnesyl pyrophosphate ammonium is used in research on cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Farnesyl diphosphate ammonium. CAS No. 116057-57-9. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg. Product ID: HY-113037C. | |
| Farrerol | Farrerol is a bioactive constituent of Rhododendron, with broad activities such as anti-oxidative, anti-inflammatory, anti-tumor, neuroprotective and hepatoprotective effects[1][2][3][4][5][6]. Uses: Scientific research. Category: Natural products. Alternative Names: (-)-Farrerol. CAS No. 24211-30-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-N0344. | |
| Farudodstat | Farudodstat (ASLAN003) is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 35 nM for human DHODH enzyme. Farudodstat inhibits protein synthesis via activation of AP-1 transcription factors. Farudodstat induces apoptosis and substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ASLAN003. CAS No. 1035688-66-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129239. | |
| Fascaplysin | Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 114719-57-2. Pack Sizes: 5 mg. Product ID: HY-112328. | |
| Fasiglifam | Fasiglifam (TAK-875) is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 72 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TAK-875. CAS No. 1000413-72-8. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10480. | |
| Fasinumab | Fasinumab (Anti-Human NGF) is a human IgG4 monoclonal antibody to nerve growth factor (NGF). Fasinumab can be used in acute sciatica and knee osteoarthritis (OA) studies[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: REGN-475; SAR-164877. CAS No. 1190239-42-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99195. | |
| Fasnall | Fasnall is a selective fatty acid synthase (FASN) inhibitor with an IC50 of 3.71 μM. Fasnall induces apoptosis in HER2+ breast cancer cell lines. Fasnall shows potent anti-tumor activities[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 929978-58-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-121250. | |
| Fast Blue B Salt, Dye content ~95% | Fast Blue B Salt, Dye content ~95% is a diazo dye, primarily used as a chromogenic substrate in biochemical analysis. Fast Blue B Salt, Dye content ~95% is the coupling agent for the histochemical demonstration of proteases. Fast Blue B Salt, Dye content ~95% can be used for the detection of acid phosphatase in Clostridium perfringens, and also for the determination of lipase activity. Fast Blue B Salt, Dye content ~95% reacts directly with the active hydroxyl groups in phenolic compounds to determine the content of phenolic substances[1][2][3][4][5][6]. . Uses: Scientific research. Category: Signaling pathways. CAS No. 14263-94-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g. Product ID: HY-W127711. | |
| Fast Blue RR Salt | Fast Blue RR Salt is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Category: Signaling pathways. CAS No. 55663-99-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g. Product ID: HY-W127771. | |
| Fast garnet GBC sulfate salt, 90% | Fast garnet GBC sulfate salt, 90% is a chromogenic substrate for alkaline phosphatase. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Azoic diazo No. 4, 90%. CAS No. 101-89-3. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg. Product ID: HY-W328317. | |
| Fast Green FCF | Fast Green FCF is a sea green triarylmethane food dye, with absorption maximum ranging from 622 to 626 nm. Fast Green FCF inhibits α-synuclein aggregation, as well as Aβ and P2X4 receptor, and TLR4/Myd88/NF-κB. Fast Green FCF is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF improves cognitive impairment, depression, relieves pain allergies, and promotes reproductive function[1][2][3][4][5][6][7][8][9]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FD&C Green No. 3; Food green 3; C.I. 42053. CAS No. 2353-45-9. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g. Product ID: HY-D0914. | |
| Fast red TR salt hemizinc chloride | Fast red TR salt hemi (zinc chloride) is a diazonium dye with red color[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 89453-69-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g. Product ID: HY-D1490. | |
| Fast-TRFS | Fast-TRFS is a selective and superfast fluorogenic probe of thioredoxin reductase (TrxR). Fast-TRFS can be used for imaging TrxR activity in live cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2966536-18-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-D1252. | |
| Fasudil | Fasudil (HA-1077; AT877) is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil is also a potent Ca2+ channel antagonist and vasodilator[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HA-1077; AT877. CAS No. 103745-39-7. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-10341A. | |
| Fasudil Hydrochloride | Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil Hydrochloride is also a potent Ca2+ channel antagonist and vasodilator[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HA-1077 Hydrochloride; AT-877 Hydrochloride. CAS No. 105628-07-7. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-10341. | |
| Fatostatin | Fatostatin (125B11), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin decreases the transcription of lipogenic genes in cells. Fatostatin possesses antitumor properties, and lowers hyperglycemia in ob/ob mice[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 125B11. CAS No. 125256-00-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-14452. | |
| Fatostatin hydrobromide | Fatostatin hydrobromide (125B11 hydrobromide), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin hydrobromide binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin hydrobromide decreases the transcription of lipogenic genes in cells. Fatostatin hydrobromide possesses antitumor properties, and lowers hyperglycemia in ob/ob mice[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 125B11 hydrobromide. CAS No. 298197-04-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 1 g. Product ID: HY-14452A. | |
| FATP1-IN-1 | FATP1-IN-1 (compound 5k) is a fatty acid transport protein 1 (FATP1) inhibitor. FATP1-IN-1 is an inhibition of recombinant human or mouse acyl-CoA synthetase activity of FATP1, with the IC50 values of 0.046 μM or 0.60 μM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1431945-95-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141699. | |
| FATP1-IN-2 | FATP1-IN-2 (compound 12a), an arylpiperazine derivative, is an orally active fatty acid transport protein 1 (FATP1) inhibitor (human IC50=0.43 μM, mouse IC50=0.39 μM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2650944-83-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141700. | |
| Favezelimab | Favezelimab (MK-4280) is a humanized monoclonal antibody targeting LAG-3. Favezelimab blocks the interaction between LAG-3 and its ligand, MHC class II molecules. Favezelimab is applicable to research on relapsed/refractory classical Hodgkin lymphoma, relapsed/refractory diffuse large B-cell lymphoma, and relapsed/refractory indolent B-cell lymphoma[1]. For the isotype control of Favezelimab, refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003). Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-4280; Mavezelimab. CAS No. 2231068-83-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99613. | |
| Favipiravir | Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC50 of 341 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: T-705. CAS No. 259793-96-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14768. | |
| FAZ-3532 | FAZ-3532 is a G3BP inhibitor (Kd = 0.54 μM) which binds to the NTF2L nsP3 binding pocket in G3BP1. FAZ-3532 disrupts the co-condensation of RNA, G3BP1, and caprin 1. FAZ-3532 inhibits G3BP-driven stress granule formation. FAZ-3532 can be studied as a powerful tool to probe the biology of stress granules and a promising interventions designed to modulate stress granule formation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3036029-72-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-162288. | |
| FAZ-3780 | FAZ-3780 is an inhibitor that binds to the NTF2L domain of G3BP1/2. FAZ-3780 binds to the NTF2L nsP3 of G3BP1 with high affinity, with a Kd of 0.15 μM and a Pep-FRET IC50 of 0.7 μM. FAZ-3780 targets the protein-protein interaction domain of G3BP1/2, and specifically inhibits the co-condensation of G3BP1, caprin 1 and RNA in vitro. FAZ-3780 inhibits stress granule formation and disassembles pre-formed stress granules. FAZ-3780 can be used in studies related to cancer and neurodegenerative diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3036029-78-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-162289. | |
| Fazamorexant | Fazamorexant (YZJ-1139) is an orally active dual orexin receptor antagonist, with an IC50 of 32 nM against OX1R and an IC50 of 41 nM against OX2R. Fazamorexant prolongs total sleep time and improves sleep efficiency. Fazamorexant is applicable to related research on insomnia[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: YZJ-1139. CAS No. 1808918-69-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152843. | |
| Fazirsiran sodium | Fazirsiran sodium is a second-generation RNAi agent. Fazirsiran sodium consistes of a cholesterol-conjugated RNAi trigger (chol-RNAi) to selectively degrade Alpha1-antitrypsin (AAT) mRNA by RNAi and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) formulated as the excipient EX1 to promote endosomal escape of the chol-RNAi in hepatocytes[1]. Fazirsiran sodium can be used in the study of Alpha-1 Antitrypsin Deficiency (AATD) liver disease. AATD is caused by mutations in the alpha-1 antitrypsin (SERPINA1) gene. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ARO-AAT sodium. CAS No. 2175009-09-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-132604A. | |
| Fazpilodemab | Fazpilodemab (BFKB8488A) is a humanized bispecific IgG1 antibody that selectively targets and activates fibroblast growth factor receptor 1c (FGFR1c) and Klothoβ. Fazpilodemab can be used for the research of type 2 diabetes mellitus (T2DM) or nonalcoholic fatty liver disease (NAFLD)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BFKB8488A; RG-7992; RO-7040551. CAS No. 2517935-02-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99614. | |
| FB23 | FB23 is a potent and selective FTO demethylase inhibitor with an IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2243736-35-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-137187. | |
| FB23-2 | FB23-2 is a potent and selective inhibitor of mRNA N6-methyladenosine (m6A) demethylase FTO, with an IC50 of 2.6 μM. FB23-2 has anti-proliferation activity. FB23-2 can be used for the research of acute myeloid leukemia (AML)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2243736-45-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-127103. | |
| FBA-IN-1 | FBA-IN-1 (compound 2a11) is a first-in-class, covalent and allosteric inhibitor of fructose-1,6-bisphosphate aldolase from Candida albicans (CaFBA). FBA-IN-1 inhibits the growth of Azole-resistant strains 103 with the MIC80 of 1 μg/mL[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2605897-57-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143899. | |
| FC-11 | FC-11 is a PROTAC FAK degrader (DC90: 1 nM). FC-11 contains CRBN ligand Pomalidomide (HY-10984), linker and FAK ligand PF562271 (HY-10459)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2271035-37-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139344. | |
| FC-116 | FC-11 is a tubulin inhibitor. FC-116 inhibits the proliferation of colorectal cancer (CRC) cells, with IC50 values of 4.52 nM for HCT116 cells and 18.69 nM for CT26 cells. FC-11 can induce ER stress to generate excess ROS, leading to mitochondrial damage, thereby promoting apoptosis in colorectal cancer (CRC) cells by targeting microtubules. FC-116 exerts potent anti-tumor effects in vivo. FC-11 can be used for the study of colorectal cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2417298-29-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-155068. | |
| Fc 11a-2 | Fc 11a-2, a benzimidazole compound, is an orally active and potent NLRP3 inflammasome inhibitor. Fc 11a-2 restrains the formation of NLRP3 inflammasome by inhibiting activation of caspase-1 and thus the activation of IL-1b/IL-18. Fc 11a-2 prevents the development of Dextran sulfate sodium (DSS; HY-116282C)-induced murine experimental colitis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 960119-75-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-111662. | |
| FC131 TFA | FC131 TFA is a CXCR4 antagonist, inhibits [125I]-SDF-1 binding to CXCR4, with an IC50 of 4.5 nM. Anti-HIV activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 842166-42-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1104A. | |
| FC-14369 | FC-14369 is a PROTAC degrader targeting the HIV-1 Nef protein, with a DC50 value of 160 nM. Through its bifunctional structure, FC-14369 binds to Nef and the Cereblon E3 ubiquitin ligase, induces Nef ubiquitination and proteasomal degradation, restores the expression of cell-surface CD4 and MHC-I, and inhibits HIV-1 replication. FC-14369 can be used in research on HIV infection and AIDS. FC-14369 is applicable to studies related to HIV-1 infection[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3066894-28-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-171860. | |
| FC9402 | FC9402 is a potent and selective sulfide quinone oxidoreductase (SQOR) inhibitor extracted from patent WO 2020/146636 A1. FC9402 attenuates TAC-induced cardiomyocyte hypertrophy and left ventricle (LV) fibrosis. FC9402 can be used for cardiovascular regulation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2452401-65-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141552. | |
| FCCP | FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone. CAS No. 370-86-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100410. | |
| FCCP (Standard) | FCCP (Standard) is the analytical standard of FCCP. This product is intended for research and analytical applications. FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (Standard). CAS No. 370-86-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100410R. | |
| F-CRI1 | F-CRI1 is a potent STING agonist with a Kd value of 40.62 nM. F-CRI1 is a radioactive probe with 18F-labeled modification. F-CRI1 can be used to study STING visualization in the tumor microenvironment[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2991453-50-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-154850. | |
| FDI-6 | FDI-6 is an inhibitor of FOXM1. FDI-6 binds directly to FOXM1 protein, to displace FOXM1 from genomic targets in MCF-7 breast cancer cells, and induce concomitant transcriptional down-regulation. Uses: Scientific research. Category: Signaling pathways. CAS No. 313380-27-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112721. | |
| FDW028 | FDW028 a potent and highly selective FUT8 inhibitor. FUT8 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the chaperone-mediated autophagy (CMA) pathway. FDW028 can be used for metastatic colorectal cancer (mCRC) research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2768426-49-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-155747. | |
| Febuxostat | Febuxostat (TEI 6720) is a potent, selective and non-purine xanthine oxidase (XO) inhibitor with a Ki value of 0.6 nM. Febuxostat has the potential for the research of hyperuricemia and gout[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TEI 6720; TMX 67. CAS No. 144060-53-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14268. | |
| Febuxostat-d7 | Febuxostat-d7 is deuterium labeled Febuxostat. Febuxostat (TEI 6720) is selective xanthine oxidase inhibitor with a Ki of 0.6 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TEI 6720-d7; TMX 67-d7. CAS No. 1285539-74-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-14268S1. | |
| Fedratinib | Fedratinib (TG-101348) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC50s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. Fedratinib induces cancer cell apoptosis and has the potential for myeloproliferative disorders research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TG-101348; SAR 302503. CAS No. 936091-26-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 2 g; 5 g. Product ID: HY-10409. | |
| Fedratinib hydrochloride hydrate | Fedratinib hydrochloride hydrate (TG-101348 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC50s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib hydrochloride hydrate shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. Fedratinib hydrochloride hydrate induces cancer cell apoptosis and has the potential for myeloproliferative disorders research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TG-101348 hydrochloride hydrate; SAR 302503 hydrochloride hydrate. CAS No. 1374744-69-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 100 mg; 200 mg; 500 mg; 1 g; 2 g; 5 g. Product ID: HY-10409A. | |
| Feladilimab | Feladilimab (Anti-ICOS/CD278 Reference Antibody (feladilimab); GSK3359609) is humanized IgG4 anti-ICOS/CD278 agonist monoclonal antibody. Feladilimab can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Anti-ICOS/CD278 Reference Antibody (feladilimab); GSK3359609. CAS No. 2252518-85-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99363. | |
| Felbamate | Felbamate (W-554) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA). Uses: Scientific research. Category: Signaling pathways. Alternative Names: W-554; ADD-03055. CAS No. 25451-15-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0184. | |
| Felezonexor | CBS9106 (SL-801) is a reversible oral CRM1 inhibitor with CRM1 degrading and antitumor activities. CBS9106, inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CBS9106; SL-801. CAS No. 1076235-04-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-108716. | |
| Felmetatug | HY-P990996 is an VTCN1-targeting IgG1κ type human antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2924808-29-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990996. | |
| Felodipine | Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 72509-76-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0309. | |
| Felodipine (Standard) | Felodipine (Standard) is the analytical standard of Felodipine. This product is intended for research and analytical applications. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 72509-76-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0309R. | |
| Felypressin | Felypressin (PLV-2) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. Felypressin is widely used in dental procedures[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PLV-2. CAS No. 56-59-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-A0182. | |
| Felzartamab | Felzartamab (MOR-202) is a human monoclonal antibody that targets CD38 and can be used in multiple myeloma research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MOR-202. CAS No. 2197112-39-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P99616. | |
| FEN1-IN-1 | FEN1-IN-1 (compound 1) is a small molecule flap endonuclease 1 (FEN1) inhibitor with antitumor activity. FEN1-IN-1 binds to the active site of FEN1 and partly achieves inhibition by the co-ordination of Mg2+ ions. FEN1-IN-1 initiaties a DNA damage response and activates the ATM checkpoint signalling pathway, the phosphorylation of histone H2AX and the ubiquitination of FANCD2 in mammalian cells. FEN1-IN-1 is promising for research of cancers[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 824983-91-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-123834. | |
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