MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| EVT0185 | EVT0185 is an orally active ATP citrate lyase (ACLY) inhibitor. EVT0185 is converted to a CoA thioester in the liver by SLC27A2 and interacts with the CoA-binding site of ACLY. EVT0185-CoA inhibits ACLY activity with an IC50 of 2.5 μM. EVT0185 can phenocopy the immune and antitumour effects of genetic ACLY deletion. EVT0185 can increase tumour-infiltrating B cells and chemokine CXCL13 levels. EVT0185 can be used for the research of cancer, such as hepatocellular carcinoma (HCC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2588489-03-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-175606. |  |
| Evunzekibart | Evunzekibart (ATOR-1017) is an Fc-γ receptor conditional 4-1BB agonist and IgG4-type antibody. Evunzekibart can be used as monotherapy or in combination with anti-PD1 to exert anticancer activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ATOR-1017. CAS No. 2639688-77-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990067. | |
| EWP 815 | EWP 815 is a disulfiram analogue, is a potent inhibitor of Ins(1,4)P2 phosphatase and Ins(1,4,5)P3 5-phosphatase. EWP 815 also inhibits enzyme dopamine β-hydroxylase activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 20231-01-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148001. | |
| EX229 | EX229, a Benzimidazole derivative, is a potent and allosteric activator of AMP-activated protein kinase (AMPK), with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1 and α1β2γ1 in biolayer interferometry, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1219739-36-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112769. | |
| Ex26 | Ex26 (S1P1-IN-Ex26) is a potent and selective sphingosine 1-phosphate receptor 1 (S1P1) antagonist (IC50=0.93 nM). Ex26 shows >3,000-fold selectivity for S1P1 over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S1P1-IN-Ex26. CAS No. 1233332-37-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-117213. | |
| Exaluren | Exaluren (ELX-02; NB-124) is an synthetic eukaryotic ribosome-selective glycoside that induces read-through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren is used for the research of cystic fibrosis caused by nonsense mutations[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ELX-02; NB-124. CAS No. 1375073-93-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-114231. | |
| Exaluren disulfate | Exaluren (ELX-02; NB-124) disulfate is an synthetic eukaryotic ribosome-selective glycoside that induces read-through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren disulfate is used for the research of cystic fibrosis caused by nonsense mutations[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ELX-02 disulfate; NB-124 disulfate. CAS No. 2244622-33-9. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg. Product ID: HY-114231B. | |
| Exarafenib | Exarafenib (RAF/KIN_2787) is an orally-available, selective pan-RAF inhibitor. Exarafenib is effective in RAF-dependent cancers, including all classes of BRAF alterations. Exarafenib suppresses MAPK signaling in RAF-dependent melanoma cell lines. Exarafenib has anticancer activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RAF/KIN_2787. CAS No. 2639957-39-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147268. | |
| Exatecan | Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DX-8951. CAS No. 171335-80-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-13631. | |
| Exatecan-d5 mesylate | Exatecan-d5 (DX8951f-d5) mesylate is deuterium labeled Exatecan mesylate (HY-13631A). Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL). Exatecan mesylate can be used in cancer research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DX8951f-d5; Deuterated labeled Exatecan mesylate. CAS No. 2819276-88-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13631AS. | |
| Exatecan mesylate | Exatecan mesylate (DX8951f) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL). Exatecan mesylate can be used in cancer research. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DX8951f. CAS No. 169869-90-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-13631A. | |
| Exatecan mesylate (GMP) | Exatecan mesylate (DX8951f ) GMP is a GMP-class Exatecan (HY-13631). Exatecan is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DX8951f (GMP). CAS No. 169869-90-3. Pack Sizes: 10 mg; 50 mg; 100 mg. Product ID: HY-13631AG. | |
| Exatecan-mpGly-Asn-Asn-(βAla) | Exatecan-mpGly-Asn-Asn-(βAla) (Compound 10b) is a conjugate of Exatecan (HY-13631) and a linker. Exatecan-mpGly-Asn-Asn-(βAla) can be used to synthesize ADCs, such as α-HER2_mpGlyAsnAsn(β-Ala)_Exatecan. Exatecan-mpGly-Asn-Asn-(βAla) can also be used in tumor research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3076725-07-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-176977. | |
| Exatecan-mpGNNG | Exatecan-mpGNNG (Compound 10a) is the linker-payload component of an antibody-drug conjugate (ADC). Exatecan-mpGNNG is composed of Exatecan (HY-13631), a potent topoisomerase I inhibitor, and the linker[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3076725-05-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-176976. | |
| Exatecan (Standard) | Exatecan (Standard) is the analytical standard of Exatecan. This product is intended for research and analytical applications. Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DX-8951 (Standard). CAS No. 171335-80-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13631R. | |
| Exemestane | Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FCE 24304; EXE. CAS No. 107868-30-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13632. | |
| Exendin-4 | Exendin-4 (Exenatide), a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC50 of 3.22 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Exenatide. CAS No. 141758-74-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13443. | |
| Exendin-4 acetate | Exendin-4 acetate (Exenatide acetate), a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC50 of 3.22 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Exenatide acetate. CAS No. 914454-01-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-13443A. | |
| Exendin(9-39) amide | Exendin(9-39) amide (Avexitide) is a glucagon-like peptide-1 (GLP-1) antagonist that competes with endogenous GLP-1 for binding to GLP-1 receptors, thereby antagonizing the effects of excess GLP-1 secretion. Exendin(9-39) amide can be used to study postoperative hypoglycemia (PBH)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Avexitide. CAS No. 133514-43-9. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0264. | |
| Exendin(9-39) amide acetate | Exendin(9-39) amide (Avexitide) acetate is a glucagon-like peptide-1 (GLP-1) antagonist that competes with endogenous GLP-1 for the GLP-1R, counteracting the effects of excessive GLP-1 secretion. Exendin(9-39) amide acetate can be utilized in Postbariatric hypoglycemia (PBH) research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Avexitide acetate. CAS No. 2051593-46-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0264A. | |
| Exicorilant | Exicorilant (CORT 125281) is a selective and oral active glucocorticoid receptor (GR) antagonist, with a Ki value of 7 nM[1]. Exicorilant (CORT 125281) has potential to overcome adiposity, glucose intolerance and dyslipidaemia[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CORT 125281. CAS No. 1781244-77-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117880. | |
| EXO1-IN-1 | EXO1-IN-1 is a human exonuclease 1 (EXO1) inhibitor (IC50 = 15.7 μM). EXO1-IN-1 inhibits DNA end resection, promotes the accumulation of DNA double-strand breaks, and triggers S-phase polyamylation. EXO1-IN-1 induces apoptosis (Apoptosis) in BRCA1-deficient breast cancer cells. EXO1-IN-1 suppresses the growth of BRCA1-deficient breast cancer xenografts. EXO1-IN-1 can be used in research related to BRCA1-deficient breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1111188-09-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-174143. | |
| Exo2 | Exo2 is a secretion inhibitor. Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Exo2 blocks secretory cargo exit from the ER (endoplasmic reticulum) and disrupts the Golgi apparatus, but does not affect the morphology of the TGN (trans-Golgi network) Exo2 can stimulate calcium-dependent exocytosis in permeabilized adrenal chromaff in cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 304684-77-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137975. | |
| exo-BCN-L-Lysine | exo-BCN-L-Lysine is a Click Amino Acid that can be used as a linker in the synthesis of PROTAC molecules. exo-BCN-L-Lysine contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1384100-45-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W754588. | |
| exo-BCN-NHS carbonate | exo-BCN-NHS carbonate carbonate contains BCN group. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1493802-77-9. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W096149. | |
| EXP3179 | EXP3179 is an important intermediate aldehyde metabolite of Losartan. EXP3179 has no AT1-R-blocking activity, but potently inhibits the expression of endothelial cyclooxygenase (COX)-2. EXP3179 exerts potent anti-inflammatory actions[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Losartan Carboxaldehyde; DuP 167. CAS No. 114798-36-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114950. | |
| EZ-482 | EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with Kds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimers diseas[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1016456-76-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103076. | |
| (E/Z)-4-Hydroxytamoxifen | (E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is a selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity, which is also an active metabolite of Tamoxifen (HY-13757A). (E/Z)-4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM). (E/Z)-4-Hydroxytamoxifen is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Afimoxifene; 4-OHT. CAS No. 68392-35-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16950A. | |
| Ezatiostat | Ezatiostat (TER199 free base; TLK199) is a tripeptide analog of glutathione and is a selective and orally active glutathione S-transferase P1-1 (GSTP1) inhibitor. Ezatiostat leads to JNK activation by inhibiting GSTP1. Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat has the potential for myelodysplastic syndrome (MDS) treatment[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TER199free base; TLK199. CAS No. 168682-53-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13634A. | |
| (E/Z)-BML264 | (E/Z)-BML264 (N-(p-amylcinnamoyl) Anthranilic Acid) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker[1][2]. (E/Z)-BML264 (N-(p-amylcinnamoyl) Anthranilic Acid) is also an effective reversible inhibitor of calcium-activated chloride channels, has potential to treat arrhythmia[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-(p-Amylcinnamoyl) anthranilic acid; ACA. CAS No. 110683-10-8. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-118628. | |
| Ezetimibe | Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SCH 58235. CAS No. 163222-33-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17376. | |
| Ezetimibe ketone | Ezetimibe ketone is an orall active Nrf2 activator and ROS inhibitor. Ezetimibe ketone attenuates H2O2-induced reactive oxygen species production and reduces H2O2-induced apoptosis in renal tubular epithelial cells. Ezetimibe ketone suppresses renal tubular injury and inflammation[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EZM-K. CAS No. 191330-56-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-133114. | |
| Ezetimibe phenoxy glucuronide | Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ezetimibe glucuronide; Ezetimibe β-D-glucuronide. CAS No. 190448-57-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-135391. | |
| Ezetimibe (Standard) | Ezetimibe (Standard) is the analytical standard of Ezetimibe. This product is intended for research and analytical applications. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SCH 58235 (Standard). CAS No. 163222-33-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17376R. | |
| EZH2-IN-14 | EZH2-IN-14 is a selective EZH2 (Histone Methyltransferase) inhibitor with an IC50 of 12 nM. EZH2-IN-14 inhibits the methyltransferase activity of EZH2/PRC2 (that is, reducing H3K27me3). EZH2-IN-14 shows >200-fold selective for EZH2 over the highly homologous H3K27 methyltransferase EZH1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1979157-17-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148458. | |
| EZH2-IN-15 | EZH2-IN-15 is a EZH2 inhibitor. EZH2-IN-15 has anti-tumor activity, and can be used for research of H3K27me3-dependent tumors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2098545-98-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153191. | |
| EZH2-IN-17 | EZH2-IN-17 (compound 28) is a potent and orally active EZH2 inhibitor with an IC50 value of 0.95 nM. EZH2-IN-17 exhibits high anti-proliferation activity against different lymphoma cell lines including WSU-DLCL2, Pfeiffer and Karpas-422 (IC50 values of 2.36 nM, 1.73 nM, and 1.82 nM, respectively)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2489672-09-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-149726. | |
| EZH2-IN-2 | EZH2-IN-2 (Example 69) is a EZH2 inhibitor with an IC50 and a TR-FRET IC50 of 64 nM and 20 nM. EZH2-IN-2 can be used for the research of cancer or precancerous condition related to EZH2 activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2238821-31-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-A0298. | |
| (E/Z)-IT-603 | (E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603 (IT-603). (E/Z)-IT-603 is also an I?Bα/c-Rel inhibitor. IT-603 is a c-Rel inhibitor with an IC50 of 3 μM. IT-603 has anti-tumor activity. (E/Z)-IT-603 is a promising modulator of T-cell responses in the context of graft-versus-host disease (GVHD) and malignant diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 292168-90-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121508. | |
| (E/Z)-J147 | (E/Z)-J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. (E/Z)-J147 can readily pass the blood brain barrier (BBB). (E/Z)-J147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter with EC50 values of 1.88 μM and 0.649 μM, respectively. (E/Z)-J147 has potential for the study of Alzheimers disease (AD)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1146963-51-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-13779. | |
| EZM0414 | EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 (IC50=18 nM in SETD2 biochemical assay; IC50=34 nM in cellular assay). EZM0414 can be used for the research of relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2411748-50-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144858. | |
| EZM0414 TFA | EZM0414 (SETD2-IN-1) TFA is the TFA salt form of EZM0414 (HY-144858). EZM0414 TFA is a potent, selective, orally active inhibitor of SETD2 (IC50=18 nM in SETD2 biochemical assay; IC50=34 nM in cellular assay). EZM0414 TFA can be used for the research of relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SETD2-IN-1 TFA. CAS No. 2411759-92-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136328. | |
| EZM 2302 | EZM 2302 is a potent and orally active CARM1 inhibitor with an IC50 value of 6 nM. EZM 2302 shows antiproliferative activity and anti-tumor activity. EZM 2302 inhibits PABP1 and SMB expression[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1628830-21-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111109. | |
| Ezurpimtrostat hydrochloride | Ezurpimtrostat hydrochloride (GNS561 hydrochloride) is an orally active PPT1 inhibitor, autophagy inhibitor, immunomodulator, anti-inflammatory agent, and anticancer agent. Ezurpimtrostat hydrochloride inhibits PPT1, dysregulates lysosomal function, redistributes mTOR, and induces apoptosis. Ezurpimtrostat hydrochloride reduces IFN - α, CRP, immune complex deposition, and SARS - CoV - 2 viral load. Ezurpimtrostat hydrochloride can be used for the study of systemic lupus erythematosus, SARS - CoV - 2, hepatocellular carcinoma, fibrosis, and related disorders[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GNS561 hydrochloride. CAS No. 1914148-73-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137978A. | |
| (E/Z)-Zotiraciclib | (E/Z)-Zotiraciclib ((E/Z)-TG02) is a potent inhibitor of CDK2, JAK2 and FLT3 with IC50s of 13, 73 and 56 nM, respectively. (E/Z)-Zotiraciclib effectively inhibits the proliferation of cancer cells, it can be used for the research of cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (E/Z)-TG02; (E/Z)-SB1317. CAS No. 937270-47-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15166. | |
| (E/Z)-Zotiraciclib citrate | (E/Z)-Zotiraciclib citrate is a potent CDK2, JAK2, and FLT3 inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (E/Z)-TG02 citrate; (E/Z)-SB1317 citrate. CAS No. 1204918-73-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15166B. | |
| F44-A13 | F44-A13 is an orally active and highly selective farnesoid X receptor (FXR) antagonist with an IC50 value of 1.1 μM. F44-A13 can optimize cholesterol metabolism and reduce its activity by inducing CYP7A1 expression. F44-A13 reduces levels of cholesterol, triglycerides, and low-density lipoprotein cholesterol (LDL-C) in mouse models. F44-A13 can be used in the study of metabolic diseases associated with lipid disorders[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1338190-14-9. Pack Sizes: 1 mg. Product ID: HY-163436. | |
| F5446 | F5446 (Compound 1) is a selective small molecule inhibitor of SUV39H1 methyltransferase. F5446 decreases H3K9me3 deposition at the FAS promoter, increases Fas expression and increases colorectal carcinoma cell sensitivity to FasL-induced apoptosis in vitro. F5446 suppresses human colon tumor xenograft growth in vivo[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2304465-89-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-150190. | |
| FABP1-IN-1 | FABP1-IN-1 (44) is a selective FABP1 inhibitor, with an IC50 of 4.46 μM. FABP1-IN-1 (44) can be used for the research of NASH[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3048021-44-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158127. | |
| FABP-IN-2 | FABP-IN-2 is a novel FABP3 ligand. FABP-IN-2 inhibits FABP3/FABP4 with an IC50 of 1.16 μM and 4.27 μM respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1426533-99-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148665. | |
| FABPs ligand 6 | FABPs ligand 6 (MF6) is an FABP5 and FABP7 inhibitor with KD values of 874 nM and 20 nM, respectively. FABPs ligand 6 can be used for multiple sclerosis research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MF6. CAS No. 2988135-14-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145990. | |
| Factor D inhibitor 6 | Factor D inhibitor 6 is a potent, highly selective and orally active factor D (FD) inhibitor with an IC50 of 30 nM and a Kd of 6 nM. Factor D inhibitor 6 is inactive against factor B, lassical and lectin complement-pathway activation, and a broad assay panel of receptors, ion channels, kinases and proteases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1386455-51-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122700. | |
| FAD-dependent glucose dehydrogenase | FAD-dependent glucose dehydrogenase (EC 1.1.5.9), or glucose dehydrogenase (FAD)/Pseudomonas glucose dehydrogenase. FAD-dependent glucose dehydrogenase is insensitive to O2 and displays high substrate specificity to glucose and thus is especially attractive enzymes for use in glucose biosensor applications[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FAD-GDH; Glucose 1-dehydrogenase. CAS No. 37250-84-3. Pack Sizes: 1 KU. Product ID: HY-E70014. | |
| Fadraciclib | Fadraciclib (CYC065) is a second-generation, orally available ATP-competitive inhibitor of CDK2/CDK9 kinases[1] with IC50s of 5 and 26 nM, respectively[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CYC065. CAS No. 1070790-89-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101212. | |
| Fadrozole hydrochloride | Fadrozole hydrochloride (CGS 16949A) is a potent, selective and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CGS 16949A; (Rac)-FAD286 hydrochloride. CAS No. 102676-31-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14247. | |
| Fagomine | Fagomine is a mild glycosidase inhibitor. The Ki of the iminosugar Fagomine is 4.8 μM, 39 μM, and 70 μM for Amyloglucosidase (A.niger), β-Glucosidase (bovine), and Isomaltase (yeast), respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-Fagomine. CAS No. 53185-12-9. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg. Product ID: HY-13005. | |
| FAICAR | FAICAR (5-Formamidoimidazole-4-carboxamide ribotide) is a purine nucleotide and the IMP cyclohydrolase substrate of Cryptococcus neoformans ATIC. It is a key intermediate in the de novo purine synthesis pathway. FAICAR can be used in studies related to Cryptococcus neoformans infection[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5-Formamidoimidazole-4-carboxamide ribotide. CAS No. 13018-54-7. Pack Sizes: 1 mg. Product ID: HY-133157. | |
| Falbikitug | Falbikitug is a humanized immunoglobulin G1-kappa, anti-LIF monoclonal antibody. Falbikitug is an antineoplastic[1]. Uses: Scientific research. Category: Inhibitory antibodies. CAS No. 2740565-02-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990039. | |
| Falcarindiol | Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells. Falcarindiol induces apoptosis and autophagy. Falcarindiol has anti-inflammatory, antifungal, anticancer and antidiabetic properties[1][2]. Falcarindiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 55297-87-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N0364. | |
| Falcarinol | Falcarinol (Panaxynol) is a natural, orally active Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Panaxynol) induces apoptosis[1]. Falcarinol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Panaxynol; Carotatoxin. CAS No. 21852-80-2. Pack Sizes: 1 mg (40.92 mM * 100 μL in Ethanol). Product ID: HY-N1455. | |
| Falecalcitriol | Falecalcitriol(Fulstan; Hornel) is an analog of calcitriol; has a higher potency both in vivo and in vitro systems, and longer duration of action in vivo. Uses: Scientific research. Category: Signaling pathways. CAS No. 83805-11-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-32342. | |
| FA-Leu-Gly-Pro-Ala-OH | FA-Leu-Gly-Pro-Ala-OH is a furylacryloyl-terminal tetrapeptide that serves as a substrate for bacterial collagenase and spirochete metalloendopeptidase. FA-Leu-Gly-Pro-Ala-OH is specifically hydrolyzed by spirochete collagenase only at the Leu-Gly bond. FA-Leu-Gly-Pro-Ala-OH can be used to determine the equilibrium constant of peptide bond hydrolysis, and also to detect collagenase-mediated cleavage reactions via turbidimetry based on absorbance reduction[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 78832-65-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P2661. | |
| Falnidamol | Falnidamol (BIBX 1382) is an orally active, selective EGFR tyrosine kinase inhibitor with an IC50 of 3 nM. Falnidamol displays > 1000-fold lower potency against ErbB2 (IC50=3.4 μM) and a range of other related tyrosine kinases (IC50>10 μM). Falnidamol is a pyrimido-pyrimidine compound and has anti-cancer activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BIBX 1382. CAS No. 196612-93-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10322. | |
| FAM amine, 6-isomer | FAM amine, 6-isomer is a fluorescein derivative with an amine group and contains an isomer of the fluorophore. Can be used to modify biomolecules through enzymatic transamination. Its fatty amine groups can also react with electrophiles such as activated esters. The amine can also be conjugated to carbonyl compounds (aldehydes and ketones) by reductive amination. Uses: Scientific research. Category: Signaling pathways. CAS No. 2183440-42-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-D1336. | |
| FAM azide, 5-isomer | FAM azide, 5-isomer is a Click Chemistry labeling reagent. Uses: Scientific research. Category: Signaling pathways. CAS No. 510758-23-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W878943. | |
| FAM azide, 6-isomer | FAM azide, 6-isomer (6-FAM azide) is a 6-carboxyfluorescein derivative with an azide functional group and coupling partner in copper-catalyzed azide-alkyne cycloaddition. FAM azide, 6-isomer participates in synthesis of fluorescently tagged disparlure enantiomers for pheromone-binding protein binding assays. FAM azide, 6-isomer is widely used for labeling oligonucleotides (Ex/Em = 493/517 nm)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 6-FAM azide. CAS No. 1386385-76-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-D1314. | |
| Famciclovir | Famciclovir (BRL 42810) is an orally active nucleoside analogue. Famciclovir is an antiviral agent with potent activities against HBV, HSV and VZV. Famciclovir can be used for the research of herpesvirus infection[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BRL 42810. CAS No. 104227-87-4. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg. Product ID: HY-17426. | |
| FAM DBCO, 6-isomer | FAM DBCO, 6-isomer represents a variant of a time-honored fluorescent dye and featuring a terminal DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. Uses: Scientific research. Category: Signaling pathways. CAS No. 2768977-07-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-W800809. | |
| Famlasertib | Famlasertib is a potent, brain-penetrant MAP4K inhibitor with IC50s value of 0.3 nM, 23.7 nM, and 44.7 nM for HGK (MAP4K4), MLK3, and MLK1, respectively. Famlasertib shows motor neuron protection and anti-inflammatory properties. Famlasertib can be used for the study of amyotrophic lateral sclerosis (ALS)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Prostetin/12k. CAS No. 2375591-69-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-168972. | |
| Famotidine | Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-208. CAS No. 76824-35-6. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0377. | |
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