MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| 7α,25-Dihydroxycholesterol | 7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7α,25-OHC. CAS No. 64907-22-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113962. |  |
| 7α,27-Dihydroxycholesterol | 7α,27-Dihydroxycholesterol is an oxysterol characterized by its oxidized side chains and is produced through the hydroxylation of 27-Hydroxycholesterol (27-OHC); it serves as a metabolite of interest in lipidomic analyses of various pathological conditions, including neurological diseases, Smith-Lemli-Opitz syndrome, obesity metabolic syndrome, and diabetes. Notably, levels of 7α,27-di-OHC decrease following lipopolysaccharide activation, and it also functions as a ligand for Epstein-Barr virus-induced gene 2 (EBI2). Additionally, 7α,27-di-OHC exists as a structural isomer of 7α,25-dihydroxycholesterol (7α25-OHC). Uses: Scientific research. Category: Signaling pathways. CAS No. 4725-24-0. Pack Sizes: 1 mg. Product ID: HY-W414548. | |
| 7α-Hydroxy-4-cholesten-3-one | 7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3862-25-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-113259. | |
| 7α-Hydroxycholesterol | 7α-Hydroxycholesterol is a cholesterol oxide and can serve as a biomarker for oxidative stress and lipid peroxidation. 7α-Hydroxycholesterol has cytotoxic and pro-inflammatory activities. 7α-Hydroxycholesterol can also inhibit sterol synthesis and reduce the activity of HMG-CoA reductase. 7α-Hydroxycholesterol can be used in the research of diseases such as diabetes and atherosclerosis[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 566-26-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N7264. | |
| 7-Amino-1-heptanol | 7-Amino-1-heptanol is a PROTAC linker that can be used in the synthesis of PROTACs. Uses: Scientific research. Category: Signaling pathways. CAS No. 19243-04-0. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W036010. | |
| 7-Amino-4-methylcoumarin | 7-Amino-4-methylcoumarin belongs to the coumarin class, can be isolated from the endophytic fungus Xylaria sp. and has a broad spectrum of antibacterial activity. 7-Amino-4-methylcoumarin is also commonly used as an important laser dye that emits in the blue region, capable of analyzing glycoprotein monosaccharides and N-linked oligosaccharides, and is also utilized in tissue pathology analysis, enzyme activity measurement, and copper ion detection. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively.[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Coumarin 120; AMC. CAS No. 26093-31-2. Pack Sizes: 10 mM * 1 mL in DMSO; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-D0027. | |
| 7-Amino-4-(trifluoromethyl)coumarin | 7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a fluorescent marker for the sensitive detection of proteinases. The excitation and emission wavelengths are 400 and 490 nm, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Coumarin 151; AFC. CAS No. 53518-15-3. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-D0981. | |
| 7-Aminoactinomycin D | 7-Aminoactinomycin D (7-AAD) a cell-impermeant fluorescent DNA stain, is a potent RNA polymerase inhibitor. 7-Aminoactinomycin D selectively binds to GC regions of the DNA. 7-Aminoactinomycin D also has antibacterial effects[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7-AAD. CAS No. 7240-37-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-D1020. | |
| 7-Aminomethyl-10-methyl-11-fluoro camptothecin | 7-Aminomethyl-10-methyl-11-fluoro camptothecin is a cytotoxin of MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (HY-132158). 7-Aminomethyl-10-methyl-11-fluoro camptothecin can be used for the synthesis of camptothecin antibody-drug conjugate (ADC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2378616-23-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-132160. | |
| 7-Benzyloxy-4-(trifluoromethyl)coumarin | 7-Benzyloxy-4-(trifluoromethyl)coumarin (7-BFC) is a coumarin fluorescent substrate. 7-Benzyloxy-4-(trifluoromethyl)coumarin is a substrate for cDNA-expressed CYP1A2 and CYP3A4 and is metabolized to 7-hydroxy-4-trifluoromethylcoumarin (HFC). 7-Benzyloxy-4-(trifluoromethyl)coumarin is used for rapid CYP isoform metabolism and inhibition screening studies[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7-BFC. CAS No. 220001-53-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W267897. | |
| 7β-Hydroxycholesterol | 7β-Hydroxycholesterol is an oxysterol that derived by the oxidation of cholesterol. 7β-hydroxycholesterol can induce cellular oxidative stress, apoptosis, and necrosis, resulting in cytotoxicity. 7β-hydroxycholesterol has antitumor activity[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 566-27-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113341. | |
| 7-BIA | 7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC50 of ~1-3 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1313403-49-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-115496. | |
| 7BIO | 7BIO (7-Bromoindirubin-3-Oxime) is the derivate of indirubin. 7BIO (7-Bromoindirubin-3-Oxime) has inhibitory effects against cyclin-dependent kinase-5 (CDK5) and glycogen synthase kinase-3β (GSK3β). 7BIO (7-Bromoindirubin-3-Oxime) inhibits Aβ oligomer-induced neuroinflammation, synaptic impairments, tau hyper-phosphorylation, activation of astrocytes and microglia, and attenuates Aβ oligomer-induced cognitive impairments in mice[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7-Bromoindirubin-3-Oxime. CAS No. 916440-85-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121035. | |
| 7-Bromohept-1-yne | 7-Bromohept-1-yne is a PROTAC linker that can be used to synthesize AK-1690 (HY-169179)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 81216-14-0. Pack Sizes: 250 mg; 1 g; 5 g; 25 g. Product ID: HY-W459522. | |
| 7-Chlorokynurenic acid sodium salt | 7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid sodium salt is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid sodium salt has potent antinociceptive actions after neuraxial delivery[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7-CKA sodium salt. CAS No. 1263094-00-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-100811A. | |
| 7-Deazaguanosine | 7-Deazaguanosine is a purine nucleoside analogue with antitrypanosomal activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 62160-23-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-152800. | |
| 7-Dehydrocholesterol | 7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D3. Uses: Scientific research. Category: Signaling pathways. CAS No. 434-16-2. Pack Sizes: 10 mM * 1 mL in Ethanol; 100 mg. Product ID: HY-113279. | |
| 7-Dehydrocholesterol-d7 | 7-Dehydrocholesterol-d7 is the deuterium labeled 7-Dehydrocholesterol. 7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D3[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 388622-58-0. Pack Sizes: 500 μg. Product ID: HY-113279S. | |
| 7-Dehydrocholesterol (Standard) | 7-Dehydrocholesterol (Standard) is the analytical standard of 7-Dehydrocholesterol. This product is intended for research and analytical applications.7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D3. Uses: Scientific research. Category: Signaling pathways. CAS No. 434-16-2. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113279R. | |
| 7-Deoxynarciclasine | 7-Deoxynarciclasine (compound 2b) can be isolated from Hymenocallis littoralis. 7-Deoxynarciclasine inhibits the cancer cell growth[1]. Uses: Scientific research. Category: Natural products. CAS No. 19622-83-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N12250. | |
| 7-Desmethyl-agomelatine | 7-Desmethyl-agomelatine is a metabolite of Agomelatine. Agomelatineis a potent agonist at melatonin receptors (MT1 and MT2), and also is an antagonist of 5-HT2C[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 152302-45-9. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg. Product ID: HY-133113. | |
| 7-Diethylaminocoumarin-3-carbohydrazide | 7-Diethylaminocoumarin-3-carbohydrazide is a coumarin. 7-Diethylaminocoumarin-3-carbohydrazide can be used to detect sugar chains and quantify biological carbonyl compounds[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DCCH. CAS No. 100343-98-4. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 1 g. Product ID: HY-D0066. | |
| 7DW8-5 | 7DW8-5 (4-Fluorophenylundecanoyl-α-galactosylceramide) is an ester product. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4-Fluorophenylundecanoyl-α-galactosylceramide. CAS No. 1056025-00-3. Pack Sizes: 500 μg. Product ID: HY-166293. | |
| 7-Epi 10-desacetyl paclitaxel | 7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC50 of 85 μM[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7-epi-10-deacetyltaxol; 10-Deacetyl-7-epipaclitaxel. CAS No. 78454-17-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-77572. | |
| 7-epi-Taxol | 7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7-epi-Paclitaxel. CAS No. 105454-04-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0227. | |
| 7-Ethoxyresorufin | 7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, especially CYP1A1. 7-Ethoxyresorufin also inhibits NO synthase[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Resorufin ethyl ether. CAS No. 5725-91-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D0145. | |
| 7-Fluorotryptamine hydrochloride | 7-Fluorotryptamine hydrochloride is a potent agonist of GPRC5A. 7-Fluorotryptamine hydrochloride induces GPRC5A-mediated β-arrestin recruitment. 7-Fluorotryptamine hydrochloride can be used for research of immune and cancer signaling[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 159730-09-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-117295A. | |
| 7H-Dibenzo[c,g]carbazole | 7H-Dibenzo[c,g]carbazole (DBC) is an azaarene with high lipophilicity. 7H-Dibenzo[c,g]carbazole has carcinogenic activity and induce DNA adducts in fish, DNA adducts, mutations in diploid human fibroblasts and micronuclei in human blood lymphocytes. 7H-Dibenzo[c,g]carbazole is activated by cytochrome P450 enzymes resulting mainly in the generation of phenolic metabolites[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DBC. CAS No. 194-59-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g; 25 g. Product ID: HY-119983. | |
| 7-Hydroxy coumarin sulfate potassium | 7-Hydroxy coumarin sulfate (7-HCS) potassium is a metabolite of 7-Ethoxycoumarin (HY-133091)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7-HCS potassium. CAS No. 1135316-80-1. Pack Sizes: 1 mg. Product ID: HY-129977. | |
| 7-Hydroxymethotrexate | 7-Hydroxymethotrexate is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 5939-37-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-130569. | |
| 7-Hydroxywarfarin | 7-Hydroxywarfarin is a Warfarin analog with anticoagulant activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Warfarin RC15. CAS No. 17834-03-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-139167. | |
| 7-Ketocholesterol | 7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bile acid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis (apoptosis)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 566-28-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113342. | |
| 7-keto-Deoxycholic acid | 7-keto-Deoxycholic acid is a metabolite of bile acids in Clostridium absonum. 7-keto-Deoxycholic acid is also converted from Lactobacillus and Bifidobacterium with specific condition[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 911-40-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-41324. | |
| 7-keto-Deoxycholic acid (Standard) | 7-keto-Deoxycholic acid (Standard) is the analytical standard of 7-keto-Deoxycholic acid. This product is intended for research and analytical applications. 7-keto-Deoxycholic acid is a metabolite of bile acids in Clostridium absonum. 7-keto-Deoxycholic acid is also converted from Lactobacillus and Bifidobacterium with specific condition[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 911-40-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-41324R. | |
| 7-Ketolithocholic acid | 7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid), a bile acid, can be absorbed and suppresses endogenous bile acid production and biliary cholesterol secretion[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3α-Hydroxy-7-oxo-5β-cholanic acid. CAS No. 4651-67-6. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-W018512. | |
| 7-MAD-MDCPT hydrochloride | 7-MAD-MDCPT hydrochloride, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2740593-09-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-132162A. | |
| 7-Methoxyrosmanol | 7-Methoxyrosmanol (7-O-Methoxyrosmanol), a phenolic diterpene isolated from rosemary, suppresses the cAMP responsiveness of PEPCK and G6Pase promoters[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7-O-Methoxyrosmanol. CAS No. 113085-62-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-111896. | |
| 7-Methyl-6-thioguanosine | 7-Methyl-6-thioguanosine (MESG) is a chromogenic substrate that can be converted to 7-methyl-6-thioguanine in the presence of purine nucleoside phosphorylase and inorganic phosphate. 7-Methyl-6-thioguanosine can be used to quantify inorganic phosphate. 7-Methyl-6-thioguanosine can also be used to determine the activities of purine nucleoside phosphorylase and protein phosphatases[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MESG. CAS No. 55727-10-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-D0995. | |
| 7-Methyladenine | 7-Methyladenine (N7-Methyladenine), a methylated analog of Adenine (HY-B0152), is a biomarker of DNA damage from exposure to methylating agents[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N7-Methyladenine. CAS No. 935-69-3. Pack Sizes: 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-116496. | |
| 7-O-(Amino-PEG4)-paclitaxel | 7-O-(Amino-PEG4)-paclitaxel is a PEG-class Drug-linker conjugates for ADC, containing a paclitaxel moiety and a amino group. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. 7-O-(Amino-PEG4)-paclitaxel can be used in the synthesis of Antibody-Drug Conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3037649-68-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-141147. | |
| 7-PPD | 7-PPD (DMPPD) is a rubber antioxidant that scavenges free radicals and inhibits the oxidative degradation of rubber chains. 7-PPD shows promise for research in tire manufacturing and rubber product processing[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DMPPD. CAS No. 3081-1-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g; 25 g. Product ID: HY-176747. | |
| 7PPD-Q | 7PPD-Q is a substituted p-phenylenediamine antioxidants derivatives. 7PPD-Q has toxic to the bacterium V. fischeri (EC50 = 14.9 mg/L)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2894124-00-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-167887. | |
| 7rh | 7rh (DDR1-IN-2) is a potent inhibitor of discoidin domain receptor 1 (DDR1), with an IC50 of 13.1 nM, and also less potently inhibits DDR2, with an IC50 of 203 nM. 7rh is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DDR1-IN-2. CAS No. 1429617-90-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00444. | |
| (7R)-SBP-0636457 | (7R)-SBP-0636457 is the isomer of SBP-0636457 (HY-125378), and can be used as an experimental control. SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an IAP antagonist. SBP-0636457 binds to the BIR-domains of the IAP proteins, with a Ki of 0.27 μM. SBP-0636457 can be used for the research of solid tumors and hematologic cancers[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (7R)-SBI-0636457; (7R)-SB1-0636457. CAS No. 1422180-61-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-125378A. | |
| 7ß,27-Dihydroxycholesterol | 7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (Ki=120 nM). 7ß,27-Dihydroxycholesterol promotes the differentiation of mouse and human CD4+ Th17 cells. 7ß,27-Dihydroxycholesterol also increases the production of IL-17 depended on CYP27A1[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7β, 27-OHC. CAS No. 240129-43-5. Pack Sizes: 1 mg. Product ID: HY-138115. | |
| 800CW NHS ester | 800CW NHS ester is a near-infrared fluorescent dye active ester that can conjugate with amine-containing small molecules, antibodies, peptides, and other substances to form fluorescent conjugates. 800CW NHS ester exhibits high fluorescence quantum yield and low non-specific binding properties. 800CW NHS ester can be used in biomedical research such as microbial infection imaging, tumor imaging, and biochemical detection[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 956579-01-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-D1872. | |
| 84-B10 | 84-B10 is a 3-phenylglutaric acid derivative. 84-B10 inhibits cisplatin (HY-17394) induced tubular ferroptosis. 84-B10 attenuates cisplatin-induced mitochondrial damage and oxidative stress. 84-B10 ameliorates cisplatin-induced acute kidney injury (AKI)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 698346-43-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-44307. | |
| 8-Aminoadenosine | 8-Aminoadenosine (8-NH2-Ado), a RNA-directed nucleoside analogue, reduces cellular ATP levels and inhibits mRNA synthesis. 8-Aminoadenosine blocks Akt/mTOR signaling and induces autophagy and apoptosis in a p53-independent manner. 8-Aminoadenosine has antitumor activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 8-NH2-Ado. CAS No. 3868-33-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-125927. | |
| 8-Aminoguanine | 8-Aminoguanine is a endogenous purine. 8-Aminoguanine inhibits PNPase (purine nucleoside phosphorylase).8-Aminoguanine induces diuresis/natriuresis/glucosuria[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 28128-41-8. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-139037. | |
| 8-Aminopyrene-1,3,6-trisulfonic acid trisodium | 8-Aminopyrene-1,3,6-trisulfonic acid trisodium (APTS) is an anionic fluorescent dye (excitation/emission: 425/503 nm in pH 7.4 PBS). The fluorescence intensity of 8-Aminopyrene-1,3,6-trisulfonic acid trisodium remains stable at pH 4-10. 8-Aminopyrene-1,3,6-trisulfonic acid trisodium retains its fluorescence properties when immobilized in a hydrogel by copolymerization. 8-Aminopyrene-1,3,6-trisulfonic acid trisodium can be used for glucose sensing[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: APTS. CAS No. 196504-57-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D0031. | |
| 8-Azaadenosine | 8-Azaadenosine is a potent ADAR1 inhibitor and an A-to-I editing inhibitor. 8-Azaadenosine blocks RNA editing and inhibits proliferation, 3D growth, invasion, and migration in thyroid cancer cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 10299-44-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115686. | |
| 8-Azaguanine | 8-Azaguanine is a purine analogue that shows antineoplastic activity. 8-Azaguanine functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 134-58-7. Pack Sizes: 100 mg; 500 mg. Product ID: HY-B1468. | |
| 8-Azahypoxanthine | 8-Azahypoxanthine is a purine analog and an inhibitor of hypoxanthine-guanine phosphoribosyltransferase (HGPRT). 8-Azahypoxanthine exhibits antitumor activity and can be used in the research of tumors such as adenocarcinoma[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2683-90-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-W070294. | |
| 8-Azanebularine | 8-Azanebularine, a compound with hydrogen in place of the C6 amino group, inhibits the ADAR2 reaction at high concentrations (IC50=15 mM). 8-Azanebularine is incorporated into an RNA structure recognized by human ADAR2 results in high-affinity binding (KD=2 nM). 8-Azanebularine can be used for the research of ADAR-catalyzed RNA-editing reaction[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 38874-46-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-145442. | |
| 8-Boc-2,8-Diazaspiro[4.5]decane hydrochloride | 8-Boc-2,8-Diazaspiro[4.5]decane (hydrochloride) is a PROTAC linker that can be used in the synthesis of PROTACs. Uses: Scientific research. Category: Signaling pathways. CAS No. 851325-42-3. Pack Sizes: 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-30592. | |
| 8-Bromo-AMP | 8-Bromo-AMP (8-Bromoadenosine 5'-monophosphate) is a membrane permeable cAMP analogue. 8-Bromo-AMP can improve the ability of the heart to recover from ischemia and reperfusion by increasing the levels of ATP, ADP, and total adenine nucleotides[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 8-Bromoadenosine 5'-monophosphate; 8-Bromoadenylic acid. CAS No. 23567-96-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-134266. | |
| 8-Bromo-cAMP | 8-Bromo-cAMP (8-Br-Camp), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP has anti-proliferative and apoptotic effects against cancer cells[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 8-Br-Camp. CAS No. 23583-48-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-12306A. | |
| 8-Bromo-cAMP sodium salt | 8-Bromo-cAMP sodium (8-Br-Camp) sodium salt, a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP sodium salt has anti-proliferative and apoptotic effects against cancer cells[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 8-Br-Camp sodium salt. CAS No. 76939-46-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12306. | |
| 8-Bromo-cGMP sodium | 8-Bromo-cGMP sodium, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator. 8-Bromo-cGMP sodium significantly inhibits Ca2+ macroscopic currents and impairs insulin release stimulated with high K+[1]. 8-Bromo-cGMP sodium has antinociceptive effects and results in vasodilator responses[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 51116-01-9. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101379A. | |
| 8-Chloroadenosine | 8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analog, depletes endogenous ATP that subsequently induces the phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death. 8-Chloroadenosine effectively inhibited in vivo tumor growth in mice[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 8-Cl-Ado. CAS No. 34408-14-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-103400. | |
| 8-CPT-Cyclic AMP sodium | 8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA). 8-CPT-Cyclic AMP sodium is also a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA) with an IC50 of 0.9 μM. 8-CPT-Cyclic AMP sodium also inhibits PDE III and PDE IV with IC50 | |
| 8-Deoxygartanin | 8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE)[1]. 8-Deoxygartanin exhibits antiplasmodial activity with an IC50 of 11.8 μM for the W2 strain of Plasmodium falciparum[2]. 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC50 of 11.3 μM[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 33390-41-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N6009. | |
| 8-Gingerol | 8-Gingerol can be found in the rhizome of ginger (Z. officinale) and has oral bioactivity. It activates TRPV1, with an EC50 value of 5.0 μM. 8-Gingerol inhibits COX-2 and also suppresses the growth of H. pylori in vitro. Additionally, 8-Gingerol exhibits anticancer, antioxidant, and anti-inflammatory properties by inhibiting the epidermal growth factor receptor (EGFR) and modulating its downstream STAT3/ERK pathway to suppress the proliferation, migration, and invasion of colorectal cancer cells. 8-Gingerol also exerts immunosuppressive effects by inhibiting oxidative stress, inducing cell cycle arrest, promoting apoptosis, and regulating autophagy. Furthermore, 8-Gingerol has cardioprotective effects. 8-Gingerol is promising for research in the fields of cancer, infection, immunosuppression, and cardiovascular diseases. Uses: Scientific research. Category: Signaling pathways. CAS No. 23513-08-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N0447. | |
| 8-Hydroxy-2'-deoxyguanosine | 8-Hydroxy-2'-deoxyguanosine is a critical biomarker of oxidative stress and carcinogenesis. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 8-Oxo-2-deoxyguanosine. CAS No. 88847-89-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W011540. | |
| 8-Hydroxy-2'-deoxyguanosine (Standard) | 8-Hydroxy-2'-deoxyguanosine is a critical biomarker of oxidative stress and carcinogenesis. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 8-Oxo-2-deoxyguanosine (Standard). CAS No. 88847-89-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W011540R. | |
| 8-Hydroxyguanine | 8-Hydroxyguanine is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine is a marker of DNA oxidative damage[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 8-Oxoguanine; 8-oxo-Gua. CAS No. 5614-64-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-113338. | |
| 8-Hydroxyguanosine | 8-Hydroxyguanosine, an oxidized nucleoside, is a marker of RNA oxidative damage and oxidative stress. 8-Hydroxyguanosine stimulates proliferation and differentiation of murine B cells with immunostimulatory activity. 8-Hydroxyguanosine is promising for research of Alzheimers disease and Downs syndrome[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3868-31-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113262. | |
| 8-Hydroxyquinoline | 8-Hydroxyquinoline (8-Quinolinol) is a lipophilic metal chelator that can be used as a fungicide.8-Hydroxyquinoline shows the MIC range of 27.56-55.11 μM (4-8 μg/mL) against the clinical isolates of Neisseria gonorrhoeae. 8-Hydroxyquinoline can bind to copper form complexes and transport copper into cells. 8-Hydroxyquinoline increases in the number of micronucleated polychromatic erythrocytes and can also make hair depigmented in mice[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 8-Quinolinol. CAS No. 148-24-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B1005. | |
| 8-Isoprostaglandin F2α | 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 8-iso-PGF2α. CAS No. 27415-26-5. Pack Sizes: 500 μg; 1 mg. Product ID: HY-113209. | |
| 8MDP | 8MDP is a potent equilibrative nucleoside transporter 1 (ENT1) inhibitor with an IC50 of 0.43 nM. 8MDP inhibits hENT1 and hENT2 uptake of [H3] uridine by K562 cells and K15NTD cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 29491-75-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-110104. | |
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