MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Absinthin | Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca2+-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46[1][2][3]. Uses: Scientific research. Category: Natural products. CAS No. 1362-42-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N0742. |  |
| ABT-072 | ABT-072 is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a EC50=1 nM; HCV GT1b EC50=0.3 nM)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1132936-00-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101634. | |
| ABT-239 | ABT-239 is a novel, highly efficacious, non-imidazole class of H3R antagonist and a transient receptor potential vanilloid type 1 (TRPV1) antagonist. Uses: Scientific research. Category: Signaling pathways. CAS No. 460746-46-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12195. | |
| ABT-510 | ABT-510 is an anti-angiogenic TSP peptide (Thrombospondin-1 analogue) that induces apoptosis and inhibits ovarian tumour growth in an orthotopic, syngeneic model of epithelial ovarian cancer. ABT-510 also reduces angiogenesis and inflammatory responses in a murine model of inflammatory bowel disease. ABT-510 can be used in studies of cancer (particularly epithelial ovarian cancer) and inflammatory bowel disease (IBD)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 251579-55-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13545. | |
| ABT-702 | ABT-702 (Adenosine Kinase Inhibitor) is a potent, orally active, and selective adenosine kinase (AK) inhibitor with an IC50 of 1.7 nM. ABT-702 shows >1300-fold selectivity for AK over other biological targets, including cyclooxygenases-1 and -2. ABT-702 attenuates inflammation in diabetic retinopathy by increasing free adenosine levels. ABT-702 shows analgesic and anti-inflammatory effects in vivo. ABT-702 can be used for diabetic retinopathy research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 214697-26-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112482. | |
| ABT-702 dihydrochloride | ABT-702 dihydrochloride is a potent adenosine kinase (AK) inhibitor (IC50=1.7 nM). Uses: Scientific research. Category: Signaling pathways. CAS No. 1188890-28-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103161. | |
| ABT-737 | ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 852808-04-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-50907. | |
| ABT-751 | ABT-751 (E7010) is a novel, highly orally bioavailable sulfonamides antimitotic compound and tubulin binder. It prevents tubulin aggregation by binding to the colchicine site on β-tubulin, leading to cell cycle arrest in G2/M phase and inducing apoptosis, thus effectively preventing cell division. ABT-751 induces autophagy by inhibiting the AKT/MTOR signaling pathway. ABT-751 showed significant inhibition against various types of cancer cells, including lung, gastric, colon, and breast cancer[1][2][3][4][5][6][7][8]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: E7010. CAS No. 141430-65-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13270. | |
| ABTS diammonium salt | ABTS diammonium salt (AzBTS-(NH4)2) is a substrate for horseradish peroxidase (HRP) conjugate. ABTS diammonium salt can be used to evaluate antioxidant capacity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AzBTS-(NH4)2. CAS No. 30931-67-0. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g. Product ID: HY-15902. | |
| Abz-AGLA-Nba | Abz-AGLA-Nba is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 100307-95-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P4406. | |
| Abz-FR-K(Dnp)-P-OH | Abz-FR-K(Dnp)-P-OH is an angiotensin I-converting enzyme (ACE) substrate and an internally quenched fluorogenic substrate for real time fluorescent assay[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 500799-61-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1853. | |
| Abz-Gly-p-nitro-Phe-Pro-OH | Abz-Gly-p-nitro-Phe-Pro-OH is the fluorescent substrate angiotensin I converting enzyme (ACE-I) with 355 nm excitation and 405 nm emission wavelengths[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 67482-93-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P4545. | |
| Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp | Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (kcat/Km = 1,570 mM-1s-1), and can be used for detection of proteinase 3 (PR3) activity[1][2]. Uses: Scientific research. Category: Peptides. CAS No. 1042405-14-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P10461. | |
| AC 187 | AC 187 is a potent and orally active amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187 shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 has neuroprotective effects[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 151804-77-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1393. | |
| AC1903 | AC1903 is a specific and selective inhibitor of TRPC5 and has podocyte-protective properties. AC1903 does no effects on TRPC4 or TRPC6 currents and shows no off-target effects in kinase profiling assays. AC1903 suppresses severe proteinuria and prevents podocyte loss in focal segmental glomerulosclerosis (FSGS) rat model[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 831234-13-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-122051. | |
| Ac2-26 | Ac2-26 is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ameliorates lung ischemia-reperfusion injury. Ac2-26 also inhibits airway inflammation and hyperresponsiveness in an asthma rat model[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 151988-33-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1098. | |
| AC 253 | AC 253, an amylin antagonist, inhibits 125I-adrenomedullin binding, with an IC50 of 25 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 151804-79-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2285. | |
| AC-261066 | AC-261066 is a potent, orally available and isoform-selective retinoic acid beta2 (RARbeta2) receptor agonist, with a pEC50 of 8.0[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 870773-76-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108532. | |
| AC-262536 | AC-262536 is a selective and non-steroidal androgen receptor modulators (SARMs) with beneficial anabolic effects. AC-262536 exhibits potent agonist activity at the androgen receptor, with an affinity in the low nanomolar range (1-10 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 870888-46-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122025. | |
| AC-263093 free base | AC-263093 free base (AC-093) functionally activates NPFFR2 and blocks activation of NPFFR1 with pKis of 6.9 and 7.0, respectively. AC-263093 free base has the potential for reversing opiate tolerance research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AC-093. CAS No. 849459-86-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124680. | |
| AC-264613 | AC-264613 is a potent and selective protease-activated receptor (PAR-2) agonist with a pEC50 of 7.5[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1051487-82-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-14351. | |
| AC-4-130 | AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1834571-82-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124500. | |
| Ac4GalNAl | Ac4GalNAl is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Ac4GalNAl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1673590-09-4. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-140343. | |
| Ac4GalNAz | Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Ac4GalNAz is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 653600-56-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141128. | |
| Ac4GlcNAlk | Ac4GlcNAlk is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1361993-37-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-141136. | |
| Ac4GlcNAz | Ac4GlcNAz (N-azidoacetylglucosamine-tetraacylated) is an azido-tagged analogue of N-acetylglucosamine (GlcNAC). It features azide functionality on the N-acyl side chain and is acetylated to aid in cell membrane permeation. Once in the cell, the acetylated compound is deprotected and takes part in the hexosamine biosynthetic pathway by action of GlcNAc kinase. The resulting modified proteins are detected by the addition of fluorescent tags under Cu(I)-catalyzed azide-alkyne cycloaddition conditions. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-azidoacetylglucosamine-tetraacylated. CAS No. 98924-81-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W039953. | |
| Ac4ManNAz | Ac4ManNAz can be taken up by cells and is an azide-containing metabolic glycoprotein labeling reagent that selectively modifies proteins. Commonly used for cell labeling, tracking and proteomic analysis. Ac4ManNAz contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Ac4ManNAz can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1213701-11-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W728531. | |
| Ac4ManNAz (80% α isomer) | Ac4ManNAz is an azido-containing metabolic glycoprotein labeling reagent. Ac4ManNAz can be used to selectively modify proteins. Ac4ManNAz can be used in cell labeling, tracking and proteomic analysis[1][2]. Ac4ManNAz is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 361154-30-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118297. | |
| AC-55541 | AC-55541 is a highly selective protease-activated receptor 2 (PAR2) agonist (pEC50=6.7), displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. AC-55541 has pEC50 values of 5.9 and 6.6 in PI hydrolysis assays and Ca2+ mobilization assays and exhibits pronociceptive activity in vivo[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 916170-19-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14350. | |
| AC-73 | AC-73 is a first specific, orally active inhibitor of cluster of differentiation 147 (CD147), which specifically disrupts CD147 dimerization, thereby mainly suppressing the CD147/ERK1/2/STAT3/MMP-2 pathways. AC-73 inhibits the motility and invasion of hepatocellular carcinoma cells[1]. AC-73 is also an anti-proliferative agent and an inducer of autophagy in leukemic cells[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 775294-71-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-122214. | |
| ACA-28 | ACA-28 is a potent ERK MAPK signaling modulator. ACA-28 selectively inhibits cancer cell growth and induces apoptosis. ACA-28 can activate nuclear factor erythroid 2-related factor 2 (Nrf2) signaling via inducing ROS production. ACA-28 can be used for the research of cancer, such as melanoma[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 948044-25-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147855. | |
| Acacetin (Standard) | Acacetin (Standard) is the analytical standard of Acacetin. This product is intended for research and analytical applications. Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5,7-Dihydroxy-4'-methoxyflavone (Standard). CAS No. 480-44-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0451R. | |
| Acalabrutinib | Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL). Acalabrutinib can be used for CLL research[1][2]. Acalabrutinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Calquence; ACP-196. CAS No. 1420477-60-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-17600. | |
| Acalabrutinib (Standard) | Acalabrutinib (Standard) is the analytical standard of Acalabrutinib. This product is intended for research and analytical applications. Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL)[1][2]. Acalabrutinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ACP-196 (Standard). CAS No. 1420477-60-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17600R. | |
| Ac-ANW-AMC | Ac-ANW-AMC is a fluorogenic substrate for immunoproteasome. Ac-ANW-AMC can be used to measure β5i activity (Ex=345 nm, Em=445 nm)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2357123-49-8. Pack Sizes: 10 mM * 1 mL in DMSO; 500 μg; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D1705. | |
| Acapatamab | Acapatamab (AMG-160) is an anti-CD3E/FOLH1 monoclonal antibody[1]. Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: AMG-160. CAS No. 2314491-93-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99418. | |
| Acarbose | Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY g 5421. CAS No. 56180-94-0. Pack Sizes: 10 mM * 1 mL in Water; 200 mg; 1 g. Product ID: HY-B0089. | |
| Acarbose (Standard) | Acarbose (Standard) is the analytical standard of Acarbose. This product is intended for research and analytical applications. Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY g 5421 (Standard). CAS No. 56180-94-0. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-B0089R. | |
| Ac-Arg-Gly-Lys(Ac)-AMC | Ac-Arg-Gly-Lys(Ac)-AMC is a substrate for HDAC[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 660846-97-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2462. | |
| Acasunlimab | Acasunlimab (GEN1046) is a bispecific antibody (bsAb) targeting PD-L1 and 4-1BB. Acasunlimab enhances T-cell and NK-cell function through conditional 4-1BB stimulation while constitutively blocking the PD-1/PD-L1 inhibitory axis. Acasunlimab can be used in research of cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GEN1046. CAS No. 2253937-12-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99419. | |
| Acazicolcept | Acazicolcept (ALPN-101), an Fc fusion protein, is a dual inducible T cell costimulator (ICOS)/CD28 antagonist. Acazicolcept has anti-inflammatory activities[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALPN-101. CAS No. 2797026-97-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99420. | |
| ACBI1 | ACBI1 is a potent and cooperative SMARCA2, SMARCA4 and PBRM1 degrader with DC50s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity. ACBI1 induces apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2375564-55-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128359. | |
| ACBI2 | ACBI2 is a highly potent and orally active VHL PROTAC SMARCA2 degrader (EC50: 7?nM), which selectively degrades SMARCA2 with a DC50 value of 1?nM in RKO cells. ACBI2 can be used in the research of lung cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2913161-19-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151623. | |
| ACBI3 | ACBI3 (compound 7), a chemical probe, is a PROTAC targeting KRAS. ACBI3 is composed of PROTAC target protein ligand pan-KRAS degrader 1 (HY-162960) (red part), E3 ligase ligand E3 ligase Ligand 43 (HY-401613) (blue part) and PROTAC Linker 1-Bromo-4-(ethynyloxy)butane (HY-169992) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is E3 Ligase Ligand-linker Conjugate 143 (HY-169995). ACBI3 achieves in vivo degradation of oncogenic KRAS, resulting in durable pathway modulation and tumor regressions in KRAS mutant xenograft mouse models[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2938169-76-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-157228. | |
| ACBI-4 | ACBI-4 is a selective GTP-loaded active state of KRAS (KRAS(on)) PROTAC degrader, with Kd values of 141 nM against KRASG12R. ACBI-4 forms a stable ternary complex with VHL, triggering ubiquitination and KRAS degradation via the ubiquitin-proteasome system. ACBI-4 induces antiproliferative effects in KRAS mutant-driven cancer cells. ACBI-4 can be used for the research of KRAS mutant-driven cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3097985-19-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-176792. | |
| Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2 | Ac-c-Pro-Pro-Lys-Asp-NH2 is a selective human melanocortin 5 receptor (hMC5R) antagonist with an IC50 of 10 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 596135-92-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4665. | |
| Ac-CoA Synthase-IN-1 | Ac-CoA Synthase-IN-1 is a potent, reversible acetate-dependent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 of 0.6 μM[1]. Ac-CoA Synthase-IN-1 inhibits the respiratory syncytial virus (RSV)[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 508186-14-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104032. | |
| Ac-(d-Arg)-CEH-(d-Phe)-RWC-NH2 | Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 is a cyclic octapeptide with MC4R agonism. Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 significantly increases heart rate and blood pressure[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 819048-44-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P4764. | |
| Ac-DEVD-AFC | Ac-DEVD-AFC is a fluorogenic substrate (λex=400 nm, λem=530 nm). Uses: Scientific research. Category: Signaling pathways. CAS No. 201608-14-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1005. | |
| Ac-DEVD-AMC | Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 169332-61-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1003. | |
| Ac-DEVD-CHO | Ac-DEVD-CHO is a Caspase-3 inhibitor with a Ki value of 230 pM. Uses: Scientific research. Category: Signaling pathways. CAS No. 169332-60-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P1001. | |
| Ac-DEVD-CMK | Ac-DEVD-CMK (Caspase-3 Inhibitor III) is a selective and irreversible caspase-3 inhibitor. Ac-DEVD-CMK significantly inhibits apoptosis induced by high levels of glucose or Ingenol 3,20-dibenzoate?(HY-137295). Ac-DEVD-CMK can be used in a variety of experimental approaches to inhibit apoptosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Caspase-3 Inhibitor III. CAS No. 285570-60-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0034. | |
| Ac-DEVD-pNA | Ac-DEVD-pNA is a ligand for caspase-3/-7 and related cysteine proteases[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 189950-66-1. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1006. | |
| ACEA | ACEA (short for arachidonyl-2'-chloroacetamide) is a synthetic organic compound that acts as an agonist of the cannabinoid receptor CB1. It is a chemical that affects the endocannabinoid system in the body, which regulates various physiological processes such as appetite, pain perception, mood, and memory[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Arachidonyl-2-chloroethylamide. CAS No. 220556-69-4. Pack Sizes: 5 mg (68.31 mM * 200 μL in Methyl acetate); 10 mg (68.31 mM * 400 μL in Methyl acetate); 25 mg (68.31 mM * 1 mL in Methyl acetate); 50 mg (68.31 mM * 2 mL in Methyl acetate). Product ID: HY-110004. | |
| Acebutolol | Acebutolol is an orally active β1 adrenergic receptor (β1AR) antagonist. Acebutolol is used for hypertension, angina pectoris and cardiac arrhythmias research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 37517-30-9. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-17497. | |
| Acebutolol-d5 | Acebutolol-d5 is the deuterium labeled Acebutolol[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1189500-68-2. Pack Sizes: 1 mg. Product ID: HY-17497S1. | |
| Acebutolol hydrochloride | Acebutolol hydrochloride is an orally active β1 adrenergic receptor (β1AR) antagonist. Acebutolol hydrochloride is used in the treatment of hypertension, angina pectoris and cardiac arrhythmias[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 34381-68-5. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-17497A. | |
| Acedoben sodium | Acedoben sodium is the sodium salt form of Acedoben. Acedoben and iron ions can construct a rapidly self-assembled coordination complex, and the Fe-Ace coordination complex can not only serve as a carrier of tumor antigens, but also enhance antigen-specific anti-tumor immunity due to its inherent adjuvant properties[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 29305-16-6. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1250A. | |
| Acelarin | Acelarin (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NUC-1031. CAS No. 840506-29-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100885. | |
| Acenaphthylene | Acenaphthylene is a polycyclic aromatic hydrocarbon (PAH). PAHs are derived naturally from coal and tar deposits, and produced by incomplete combustion of organic matter[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 208-96-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-W013570. | |
| Acepromazine | Acepromazine (Acetopromazine) is a phenothiazine tranquilizer and is alpha-adrenoceptor antagonist[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Acetopromazine; Acetylpromazine. CAS No. 61-00-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1506. | |
| Acepromazine maleate | Acepromazine (Acetopromazine) maleate is a phenothiazine tranquilizer and is alpha-adrenoceptor antagonist[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Acetopromazine maleate; Acetylpromazine maleate. CAS No. 3598-37-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-B1506A. | |
| Acesulfame potassium | Acesulfame potassium is a synthetic sweetener. Long-term use of Acesulfame potassium can affect cognitive function, possibly by altering the neurometabolic functions in mice. Acesulfame potassium can suppress autophagic degradation of PD-L1 in RIL-175 and SK-Hep1 cells through the ERK1/2-mTORC1-ULK1 pathway, which may be related to immune evasion in cancer cells. Acesulfame potassium can be used in research on neurological diseases, metabolic disorders, cancer, and immune evasion[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 55589-62-3. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-D0195. | |
| Acetaldehyde 2,4-Dinitrophenylhydrazone-3,5,6-d3 | Acetaldehyde 2,4-Dinitrophenylhydrazone-3,5,6-d3 is the deuterium labeled Acetaldehyde 2,4-Dinitrophenylhydrazone-3,5,6[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 259824-51-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-141855S. | |
| Acetaminophen | Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent.[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4]. Acetaminophen induces ferroptosis and leads to acute liver injury in mice model[5]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide. CAS No. 103-90-2. Pack Sizes: 500 mg; 5 g; 10 g. Product ID: HY-66005. | |
| Acetaminophen-d3 | Acetaminophen-d3 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Paracetamol-d3; 4-Acetamidophenol-d3; 4'-Hydroxyacetanilide-d3. CAS No. 60902-28-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-66005S1. | |
| Acetaminophen-d4 | Acetaminophen-d4 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Paracetamol-d4; 4-Acetamidophenol-d4; 4'-Hydroxyacetanilide-d4. CAS No. 64315-36-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-66005S. | |
| Acetaminophen glucuronide | Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005)[1][2]. Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: APAP-glu. CAS No. 16110-10-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113083. | |
| Acetaminophen glucuronide sodium salt | Acetaminophen glucuronide is a safe and effectiveantipyretic analgesic. Acetaminophen glucuronide is potentially toxic to liverand kidney [1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: p-Acetamidophenyl β-D-glucuronide sodium salt; p-AAPG sodium salt. CAS No. 120595-80-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-W016034. | |
| Acetaminophen (Standard) | Acetaminophen (Standard) is the analytical standard of Acetaminophen. This product is intended for research and analytical applications. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Paracetamol (Standard); 4-Acetamidophenol (Standard); 4'-Hydroxyacetanilide (Standard). CAS No. 103-90-2. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-66005R. | |
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