MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| NITD008 | NITD008 is a potent and selective flaviviruse inhibitor which can inhibit Dengue Virus Type 2 (DENV-2) with an EC50 of 0.64 μM. NITD008 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7-Deaza-2'-C-acetylene-adenosine. CAS No. 1044589-82-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-12957. |  |
| NITD-349 | NITD-349 is an MmpL3 inhibitor that shows highly potent anti-mycobacterial activity with MIC50 of 23 nM against virulent Mycobacterium tuberculosis H37Rv. Uses: Scientific research. Category: Signaling pathways. CAS No. 1473450-62-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109588. | |
| NITD-688 | NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the research of dengue virus (DENV)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EYU-688. CAS No. 2407227-31-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138543. | |
| NITD-916 | NITD-916, a 4-hydroxy-2-pyridone derivative, is an orally active mycobacterial enoyl reductase InhA inhibitor with an IC50 of 570 nM. NITD-916 forms a ternary complex with InhA and NADH to block access to the fatty acyl substrate binding pocket. NITD-916 inhibition of InhA reduces the synthesis of mycolic acids and results in cell death. NITD-916 has potent anti-tuberculosis effects[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1614262-83-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-122643. | |
| Nitecapone | Nitecapone (OR-462) is an orally active and short-acting catechol-O-methyltransferase (COMT) inhibitor with gastroprotective and antioxidant properties. Nitecapone (OR-462) scavenges reactive oxygen and nitric radicals and prevents lipid peroxidation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OR-462. CAS No. 116313-94-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-106842. | |
| Nitidine chloride | Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway, also has anti-inflammatory activity. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 13063-04-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N0498. | |
| Nitisinone | Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC50 of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NTBC; Nitisone; SC0735. CAS No. 104206-65-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0607. | |
| Nitracrine | Nitracrine inhibits RNA synthesis and covalently, reversibly binds to DNA but also forms covalent adducts with DNA in vivo. Nitracrine, a 1-nitroacridine derivative, is a potent hypoxia-selective agent in vitro and antitumor agent. Nitracrine has cytotoxicity towards most cells[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4533-39-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00279. | |
| Nitrendipine | Nitrendipine (BAY-E-5009) is an orally active analog of Nifedipine (HY-B0284) and dihydropyridine calcium channel blocker. Nitrendipine induces Apoptosis. Nitrendipine has antihypertensive effects. Nitrendipine blocks alcohol and Morphine withdrawal symptoms. Nitrendipine reduces right ventricular hypertrophy and pulmonary vascular changes induced by intermittent hypoxia. Nitrendipine has anticancer effects on neuroblastoma[1][2][3][4][5][6][7][8][9][10][11]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY-E-5009. CAS No. 39562-70-4. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-B0424. | |
| Nitrendipine (Standard) | Nitrendipine (Standard) is the analytical standard of Nitrendipine (HY-B0424). This product is intended for research and analytical applications. Nitrendipine (BAY-E-5009) is an orally active analog of Nifedipine (HY-B0284) and dihydropyridine calcium channel blocker. Nitrendipine induces Apoptosis. Nitrendipine has antihypertensive effects. Nitrendipine blocks alcohol and Morphine withdrawal symptoms. Nitrendipine reduces right ventricular hypertrophy and pulmonary vascular changes induced by intermittent hypoxia. Nitrendipine has anticancer effects on neuroblastoma[1][2][3][4][5][6][7][8][9][10][11]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY-E-5009 (Standard). CAS No. 39562-70-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-B0424R. | |
| Nitrilase | Nitrilase is able to hydrolyze nitriles into their corresponding carboxylic acids and ammonia. Nitrilase is a green biocatalyst for the production of high value-added products[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9024-90-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3188. | |
| Nitrilotriacetic acid | Nitrilotriacetic acid is an orally active chelating agent for metal ions. Nitrilotriacetic acid is an aminotricarboxylic acid that can sequester metal ions as water soluble complexes. Nitrilotriacetic acid reacts with strong oxidizing agents such as hypochlorite, chlorine, ozone, or oxygen in the presence of palladium/carbon catalyst. Nitrilotriacetic acid interacts with solid phases such as cell membranes and bone matrices in the mammalian system. Nitrilotriacetic acid is classified as an epigenetic rodent carcinogen[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Triglycollamic acid. CAS No. 139-13-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-W030778. | |
| Nitrobenzylthioinosine | Nitrobenzylthioinosine is an ENT1 transporter inhibitor that binds to ENT1 transporter with high affinity. Nitrobenzylthioinosine is a photoaffinity probe for adenosine uptake sites in brain. Nitrobenzylthioinosine can cross the blood-brain barrier[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NBMPR. CAS No. 38048-32-7. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W010936. | |
| Nitro blue tetrazolium chloride | Nitro blue tetrazolium chloride (NBT) is a substrate for dehydrogenases; is used with the alkaline phosphatase substrate 5-Bromo-4-Chloro-3-Indolyl Phosphate (BCIP) in western blotting and immunohistological staining procedures[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NBT. CAS No. 298-83-9. Pack Sizes: 250 mg; 500 mg; 1 g. Product ID: HY-15925. | |
| Nitrocefin | Nitrocefin is a highly activated, chromogenic cephalosporin derivative. Nitrocefin is a chromogenic β-lactamase substrate. Nitrocefin undergoes a distinctive color change from yellow to red as the amide bond in the β-lactam ring is hydrolyzed by β-lactamase. Nitrocefin is used in competitive inhibition studies in developmental work on β-lactamase-resistant antibiotics[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 41906-86-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108913. | |
| Nitrochin | Nitrochin (4-NQO) is a chemical carcinogen. Nitrochin induces oncostatin-M (OSM) in esophageal cells. Nitrochin induces DNA damage, and induces apoptosis via a p53-dependent mitochondrial signaling pathway[1][2]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: 4-NQO. CAS No. 56-57-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-33354. | |
| Nitrofurantoin | Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. Nitrofurantoin acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 67-20-9. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-A0090. | |
| Nitrosobenzene | Nitrosobenzene is a radical scavenger that can be used to study oxidative DNA damage and the respiratory burst reaction of neutrophils induced by nitro compounds[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 586-96-9. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g. Product ID: HY-121641. | |
| Nitrosoglutathione | Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSNO; RVC-588; S-Nitroso-L-glutathione. CAS No. 57564-91-7. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-D0845. | |
| Nitrovin hydrochloride | Nitrovin hydrochloride is an antibacterial growth promoter. Nitrovin hydrochloride induces ROS-mediated non-apoptotic and apoptotic-like cell death by targeting TrxR1. Nitrovin hydrochloride has anticancer activity, with IC50 values of 1.31-6.60 μM for tumor and normal cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Difurazon hydrochloride. CAS No. 2315-20-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129751. | |
| Nitroxoline | Nitroxoline (8-Hydroxy-5-nitroquinoline), an antibiotic, is an orally active antibiofilm agent. Nitroxoline reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Nitroxoline can be used for the urinary tract infections and cancer research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 8-Hydroxy-5-nitroquinoline; 5-Nitro-8-quinolinol. CAS No. 4008-48-4. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g. Product ID: HY-B1159. | |
| Nivalenol | Nivalenol, a trichothecene mycotoxin that can be produced by Fusarium graminearum, is a fungal metabolite present in agricultural product. Nivalenol modulates apoptotic pathway, cell cycle regulation, Bax, ERK, caspase-3, and poly-ADP-ribose synthase activity in macrophages. Nivalenol inhibits ribosomal peptidyltransferase site, protein synthesis, DNA synthesis, and cell proliferation. Nivalenol induces late-stage apoptotic morphological changes, reduces cellular metabolism, and decreases cell proliferation in erythroleukemia cells. Nivalenol induces lymphocyte apoptosis in murine thymus, spleen, and Peyer's patches. Nivalenol can be used for the research of erythroleukemia[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 23282-20-4. Pack Sizes: 1 mg. Product ID: HY-N6801. | |
| Nivasorexant | Nivasorexant (ACT-539313) is an orally active, blood-brain barrier penetrant, selective orexin OX1R inhibitor. Nivasorexant specifically blocks central OX1Rs without affecting OX2Rs, and exhibits competitive inhibitory activity against CYP2C8, CYP2C9, CYP2C19 and CYP3A4 (IC50 values are 25 μM, 8.6 μM, 1.6 μM, 19 μM/44 μM, respectively). Nivasorexant significantly reduces binge-like eating behavior of highly palatable food in rat models and has long-acting properties. Nivasorexant shows no relevant off-target activity against over 130 selected proteins, exhibits favorable safety profiles, and can be used for studies related to binge eating disorder[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ACT-539313. CAS No. 1435480-40-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147294. | |
| Nivisnebart | HY-P991011 is an SORT1-targeting IgG1κ type human antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001)[1]. Uses: Scientific research. Category: Inhibitory antibodies. CAS No. 2923556-87-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P991011. | |
| Nivolumab | Nivolumab is a programmed death receptor-1 (PD-1) blocking human IgG4 antibody to treat advanced (metastatic) non-small cell lung cancer. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-936558; ONO-4538; MDX-1106. CAS No. 946414-94-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P9903. | |
| NJH-2-030 | NJH-2-030 can be used as a covalent recruiter for FEM1B in targeted protein degradation applications. Uses: Scientific research. Category: Signaling pathways. CAS No. 2709040-02-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143348. | |
| NJH-2-057 | NJH-2-057 is an EN523 OTUB1 recruiter linked to lumacaftor, a agent used to treat cystic fibrosis that binds ΔF508-CFTR. Uses: Scientific research. Category: Signaling pathways. CAS No. 2858812-70-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115878. | |
| NK-252 | NK-252 is a potential Nrf2 activator, which exhibits a great Nrf2-activating potential. Uses: Scientific research. Category: Signaling pathways. CAS No. 1414963-82-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19734. | |
| N-(Ketocaproyl)-DL-homoserine lactone | N-(Ketocaproyl)-DL-homoserine lactone is a natural, very active ligand of LuxR. N-(Ketocaproyl)-DL-homoserine lactone is a quorum sensing (QS) autoinducer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 76924-95-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129405. | |
| NKH477 | NKH477 (Colforsin dapropate hydrochloride) directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 is a forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Colforsin dapropate hydrochloride. CAS No. 138605-00-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103193. | |
| NKY80 | NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC50s of 8.3 μM, 132 μM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 299442-43-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103195. | |
| NL-1 | NL-1 is a mitoNEET inhibitor with antileukemic effect. NL-1 inhibits REH and REH/Ara-C cells growth with IC50s of 47.35 μM and 56.26 μM, respectively. NL-1-mediated death in leukemic cells requires the activation of the autophagic pathway[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 188532-26-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-135231. | |
| NL3 | NL3 is a bacterial cystathionine γ-lyase inhibitor, with IC50s of 0.7 μM (bCSE) and 3.4 μM (hCSE) respectively. NL3 can be used for antimicrobial and circumventing bacterial resistance research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2395867-03-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-170028. | |
| N-Lactoyl-phenylalanine | N-Lactoyl-phenylalanine is a blood-derived signaling metabolite that can be induced by exercise. N-Lactoyl-phenylalanine can reduce obesity and improve glucose tolerance[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Lac-Phe. CAS No. 183241-73-8. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150012. | |
| N-Lactylleucine | N-Lactylleucine is an endogenous metabolite that can be identified in patients with the intermediate type of maple syrup urine disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 112757-17-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164805. | |
| NLRP3/AIM2-IN-3 | NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC50 of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3 disturbs the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1787787-60-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144226. | |
| NLRP3-IN-13 | NLRP3-IN-13 (Compound C77 in reference patent) is a selective and potent NLRP3 inhibitor (IC50: 2.1 μM). NLRP3-IN-13 inhibits NLRP3 andNLRC4 inflammasomes, and inhibits NLRP3-mediated IL-1β production. NLRP3-IN-13 also inhibits NLRP3 ATPase activity. NLRP3-IN-13 can be used in the research of neuroinflammatory disorders[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1704638-35-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150206. | |
| NLRP3-IN-17 | NLRP3-IN-17 is a potent, selective and orally active NLRP3 inflammasome inhibitor with an IC50 value of 7 nM. NLRP3-IN-17 significantly inhibits NLRP3 dependent IL-1β secretion in mice and can be used for chronic inflammatory diseases research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2254432-75-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153261. | |
| NLRP3-IN-25 | NLRP3-IN-25 (compound 32) is an orally available NLRP3 inhibitor with anti-inflammatory activity. NLRP3-IN-25 attenuates renal injury in doxorubicin-induced glomerulonephritis in mice. NLRP3-IN-25 inhibits IL-1β secretion in THP-1 cells with an IC50 of 21 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2660230-90-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155463. | |
| NLS (PKKKRKV) | NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the SV40 large T antigen, which mediates the binding of karyophilic proteins to importin α. NLS (PKKKRKV) serves as a method to enhance nuclear entry in the field of gene transfer research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 95088-49-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P1876. | |
| NM107 | NM107 (2'-C-Methylcytidine) is an nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase, the EC50 of NM107 in the wild-type replicon cells is 1.85 μM[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2'-C-Methylcytidine. CAS No. 20724-73-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-10468. | |
| N-Mal-N-bis(PEG2-NHS ester) | N-Mal-N-bis(PEG2-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2182601-73-4. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-140571. | |
| NMD670 | NMD670 is an orally active inhibitor of skeletal muscle specific chloride channel ClC-1 with an EC50 of 1.6 μM. NMD670 enhances neuromuscular transmission and improves muscle contraction and strength. NMD670 can be used in the study of muscle weakness and muscle fatigue[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2354321-33-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158183. | |
| NMDA | NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Methyl-D-aspartic acid. CAS No. 6384-92-5. Pack Sizes: 50 mg; 100 mg. Product ID: HY-17551. | |
| NMDI14 | NMDI14 is a nonsense mediated RNA decay (NMD) inhibitor. NMDI14 disrupts the SMG7-UPF1 interactions and inhibits NMD. Uses: Scientific research. Category: Signaling pathways. CAS No. 307519-88-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111374. | |
| N-Methyl-4-pyridone-3-carboxamide | N-Methyl-4-pyridone-3-carboxamide (compound 4PY) is a final product of nicotinamide adenine dinucleotide (NAD) degradation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 769-49-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113472. | |
| N-Methyl-4-pyridone-3-carboxamide-d3 | N-Methyl-4-pyridone-3-carboxamide-d3 is deuterium labeled N-Methyl-4-pyridone-3-carboxamide. Uses: Scientific research. Category: Signaling pathways. CAS No. 1207384-47-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-113472S. | |
| (±)-N-Methylcoclaurine | (±)-N-Methylcoclaurine is a selective α2-adrenoceptor antagonist[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1472-62-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-155879. | |
| N-Methyldopamine hydrochloride | N-Methyldopamine hydrochloride is a precursor of adrenaline in the adrenal medulla. N-Methyldopamine hydrochloride is a modification of the dopamine (DA), and retains agonist activity at the DA1 receptor. N-Methyldopamine hydrochloride remains capable of universal surface coating and secondary reactions using the surface catechols. N-Methyldopamine hydrochloride can be used for heart failure research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 62-32-8. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg; 250 mg. Product ID: HY-W014728. | |
| N-Methylhistamine dihydrochloride | N-Methylhistamine (Nα-Methylhistamine) dihydrochloride is a potent agonist of the histamine H3 receptor, exhibiting significant implications in the diagnosis and management of mastocytosis. N-Methylhistamine (dihydrochloride) also serves as a biomarker for assessing mast cell accumulation in clinical evaluations. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Nα-Methylhistamine dihydrochloride. CAS No. 16503-22-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101005. | |
| N-Methylmesoporphyrin IX | N-Methylmesoporphyrin IX (NMM), a widely used G-quadruplex DNA specific fluorescent binder, is an efficient probe for monitoring Aβ fibrillation. N-Methylmesoporphyrin IX is an in situ inhibitor and an ex situ monitor for Aβ amyloidogenesis both in vitro and in cells. N-Methylmesoporphyrin IX is sensitive to G-quadruplexes DNA but has no response to duplexes, triplexes and single-stranded forms DNA. N-Methylmesoporphyrin IX is nonfluorescent alone or in monomeric Aβ environments, but emits strong fluorescence through stacking with the Aβ assemblies[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 142234-85-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133821. | |
| N-Methylnicotinamide | N-Methylnicotinamide is an endogenous metabolite with antithrombotic effect. N-Methylnicotinamide via production/release of prostacyclin inhibits arterial thrombosis development. N-Methylnicotinamide is also the N-methylation product from nicotinamide catalyzed by N-methyltransferase within nicotinate and nicotinamide metabolism pathway[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 114-33-0. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-124124. | |
| N-Methylnicotinamide-d4 | N-Methylnicotinamide-d4 is the deuterium labeled N-Methylnicotinamide (HY-124124). N-Methylnicotinamide is an endogenous metabolite with antithrombotic effect. N-Methylnicotinamide via production/release of prostacyclin inhibits arterial thrombosis development. N-Methylnicotinamide is also the N-methylation product from nicotinamide catalyzed by N-methyltransferase within nicotinate and nicotinamide metabolism pathway. Uses: Scientific research. Category: Signaling pathways. CAS No. 2708278-64-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-124124S. | |
| N-Methylprotoporphyrin IX | N-Methylprotoporphyrin IX is a Ferrochelatase inhibitor with a Kiapp value of 3 nM. N-methylprotoporphyrin IX dimethyl ester potently inhibits the synthesis of phycocyanin and chlorophyll a. N-Methylprotoporphyrin IX can be used for the research of haem deficiency-associated disorders[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 79236-56-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg. Product ID: HY-129430. | |
| N-Methylpyrrolidone | N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD50 value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NMP; 1-Methyl-2-pyrrolidinone. CAS No. 872-50-4. Pack Sizes: 10 mM * 1 mL in DMSO; 50 g; 100 g; 500 g; 1 k g. Product ID: HY-Y1275. | |
| NMI 8739 | NMI 8739 is a dopamine D2 autoreceptor agonist, which is an amine conjugate of the DHA carrier and the neurotransmitter dopamine. Uses: Scientific research. Category: Signaling pathways. CAS No. 129024-87-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101540. | |
| NMS-859 | NMS-859 is a potent, covalent VCP (p97) inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1449236-96-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15714. | |
| NMS-873 | NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with an IC50 value of 30 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1418013-75-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15713. | |
| NMS-P118 | NMS-P118 is a potent, orally available, and highly selective PARP-1 Inhibitor for cancer therapy. Uses: Scientific research. Category: Signaling pathways. CAS No. 1262417-51-5. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-18954. | |
| NMT-IN-1 | NMT-IN-1 is a Trypanosoma brucei N-myristoyltransferase (TbNMT) inhibitor, with an IC50 of 31 μM against TbNMT and an IC50 of 66 μM against hNMT. As a thiazolidinone hit compound identified via virtual screening, NMT-IN-1 exerts enzymatic inhibitory effects by binding to the active site of TbNMT. NMT-IN-1 adopts a binding mode distinct from that of pyrazole sulfonamide inhibitors and can inhibit the myristoyl transfer reaction catalyzed by TbNMT. NMT-IN-1 is mainly used in the research of anti-parasitic lead compounds for human African trypanosomiasis (African sleeping sickness). It provides a structural basis for the subsequent optimization of TbNMT inhibitors with high activity, high selectivity and blood-brain barrier permeability[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 326879-46-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-153021. | |
| NMT-IN-7 | NMT-IN-7 is a N-myristoyl transferase (NMT) inhibitor, with IC50s of 2.1 nM for HsNMT1M, 0.6 nM for SU-DHL-10 cell. NMT-IN-7 can be used as a ADC cytotoxin[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3032302-70-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-160945. | |
| N,N-Bis(trifluoromethylsulfonyl)aniline | N,N-Bis(trifluoromethylsulfonyl)aniline (N-Phenyltrifluoromethanesulfonimide) is a sulfonylation reagent. N,N-Bis(trifluoromethylsulfonyl)aniline can be used for the synthesis of organic compounds[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Phenyltrifluoromethanesulfonimide. CAS No. 37595-74-7. Pack Sizes: 10 mM * 1 mL in DMSO; 10 g; 25 g; 50 g; 100 g. Product ID: HY-40293. | |
| NNC 05-2090 hydrochloride | NNC 05-2090 hydrochloride is a GABA uptake inhibitor and inhibitor of the β-GABA transporter (BGT-1) (IC50< /sub>: 10.6 μM). NNC 05-2090 hydrochloride also inhibits mGAT2 with a Ki value of 1.4 μM. NNC 05-2090 has anticonvulsant activity and can be used in the study of epilepsy and neurological diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 184845-18-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-103509. | |
| NNC-0640 | NNC-0640 is an effective negative allosteric modulator (NAM) of the human glucagon receptor (GCGR), with an IC50 value of 69.2 nM. NNC-0640 holds potential for research in the field of diabetes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 307986-98-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124622. | |
| NNC 55-0396 | NNC 55-0396 (NNC 55-0396 dihydrochloride) is a blood-brain-barrier-permeable T-type Ca2+ channel inhibitor and pan-P450 inhibitor. NNC 55-0396 selectively inhibits T-type Ca2+ channels, suppresses HIF-1α expression and stability and inhibits Kv currents. NNC 55-0396 reduces brain infarct and attenuates neurological dysfunction. NNC 55-0396 inhibits the activity of multiple P450 enzymes. NNC 55-0396 (free base) can be used for the research of brain injury, hypertension, and glioblastoma[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NNC 55-0396 dihydrochloride. CAS No. 357400-13-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50722. | |
| NNC-711 | NNC-711 (NO-711 hydrochloride) is a potent and selective inhibitor of GAT-1 (GABA transporter 1) with IC50 values of 0.04, 0.38, 171, 1700, 349, 622 μM for human GAT-1, rat GAT-1, rGAT-2, hGAT-3, rGAT-3, hBGT-3, respectively. NNC-711 has anticonvulsant and analgesic effect in vivo and exhibits cognition-enhancing activity[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NO-711 hydrochloride. CAS No. 145645-62-1. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103506. | |
| N,N'-Carbonyldiimidazole | N,N'-Carbonyldiimidazole (1,1'-Carbonyldiimidazole) is a highly reactive carboxylating reagent that can activate hydroxyl groups to form reactive carbonyl groups. N,N'-Carbonyldiimidazole can be used as a coupling agent and a peptide synthesis reagent[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1,1'-Carbonyldiimidazole. CAS No. 530-62-1. Pack Sizes: 10 mM * 1 mL in DMSO; 100 g; 250 g; 500 g. Product ID: HY-79880. | |
| N,N'-Diacetylchitobiose | N,N'-Diacetylchitobiose is a dimer of β(1,4) linked N-acetyl-D glucosamine. N,N'-Diacetylchitobiose is the hydrolysate of chitin and can be used as alternative carbon source by E. coli. N,N'-Diacetylchitobiose also reverses myocardial depression[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 35061-50-8. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130778. | |
| N,N'-Diacetyl-L-cystine | N,N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DiNAC; (Ac-Cys-OH)2. CAS No. 5545-17-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-114348. | |
| N,N'-Di-Boc-1H-pyrazole-1-carboximidamide | N,N'-Di-Boc-1H-pyrazole-1-carboximidamide (Compound 1) is a guanylating agent. N,N'-Di-Boc-1H-pyrazole-1-carboximidamide reacts with amines and amino acids[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 152120-54-2. Pack Sizes: 10 mM * 1 mL in DMSO; 10 g; 25 g; 50 g; 100 g. Product ID: HY-W002736. | |
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