MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Nicardipine hydrochloride | Nicardipine hydrochloride (YC-93) is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine hydrochloride acts as an agent for chronic stable angina and for controlling blood pressure[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: YC-93. CAS No. 54527-84-3. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-12515A. |  |
| NICE-01 | NICE-01 (AP1867-PEG2-JQ1; AP-PEG2-JQ1) is a bifunctional compound that bind to proteins in separate cellular compartments that can induce nuclear import of cytosolic cargoes, using nuclear-localized bromodomain-containing protein 4 (BRD4) as a carrier for co-import and nuclear trapping of cytosolic proteins[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AP1867-PEG2-JQ1; AP-PEG2-JQ1. CAS No. 2982819-94-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-156214. | |
| Niclosamide | Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research[1]. Niclosamide is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[4]. Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells[2][3][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY2353. CAS No. 50-65-7. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g; 10 g. Product ID: HY-B0497. | |
| Nicorandil | Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SG-75. CAS No. 65141-46-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B0341. | |
| Nicotelline | Nicotelline (Nicotellin) is a nicotine-related alkaloid, as well as a weak inhibitor of human cDNA-expressed cytochrome P-450 2A6 (CYP2A6). CYP2A6 mediates coumarin 7-hydroxylation, while Nicotelline fails to exhibit inhibition at 300 μM. Nicotelline can be used as a tracer and biomarker of particulate matter (PM) derived from tobacco smoke[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Nicotellin. CAS No. 494-04-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135560. | |
| Nicotiflorin | Nicotiflorin is a flavonoid glycoside extracted from a traditional Chinese medicine Carthamus tinctorius. Nicotiflorin shows potent antiglycation activity and neuroprotection effects. Uses: Scientific research. Category: Natural products. CAS No. 17650-84-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-N1475. | |
| Nicotinamide | Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Niacinamide; Nicotinic acid amide. CAS No. 98-92-0. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-B0150. | |
| Nicotinamide 1,N6-ethenoadenine dinucleotide | Nicotinamide 1,N6-ethenoadenine dinucleotide (ε-NAD) is a fluorescent analog of NAD. Nicotinamide 1,N6-ethenoadenine dinucleotide can be cleaved by phosphodiesterase I (from C. adamanteus venom) and binds to bovine liver glutamate dehydrogenase. Nicotinamide 1,N6-ethenoadenine dinucleotide can serve as a substrate for G-ADP ribosylation of G proteins catalyzed by bacterial toxins. Nicotinamide 1,N6-ethenoadenine dinucleotide can be used as a fluorescent substrate for the study of ADP ribosylation reactions[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ε-NAD. CAS No. 38806-38-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-137592. | |
| Nicotinamide-d4 | Nicotinamide-d4 is the deuterium labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Niacinamide-d4; Nicotinic acid amide-d4. CAS No. 347841-88-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-B0150S. | |
| Nicotinamide N-oxide | Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor. Uses: Scientific research. Category: Signaling pathways. CAS No. 1986-81-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-101407. | |
| Nicotinamide riboside chloride | Nicotinamide riboside Chloride, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimers disease[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 23111-00-4. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-123033A. | |
| Nicotinamide riboside chloride (Standard) | Nicotinamide riboside (chloride) (Standard) is the analytical standard of Nicotinamide riboside (chloride). This product is intended for research and analytical applications. Nicotinamide riboside Chloride, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimers disease[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 23111-00-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123033AR. | |
| Nicotinamide (Standard) | Nicotinamide (Standard) is the analytical standard of Nicotinamide. This product is intended for research and analytical applications. Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Niacinamide(Standard); Nicotinic acid amide (Standard). CAS No. 98-92-0. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-B0150R. | |
| Nicotinic acid mononucleotide | Nicotinic acid mononucleotide acts as a SARM1 inhibitor and a NAD+ biosynthesis intermediate, with an IC50 value of 93.3 μM against SARM1. Nicotinic acid mononucleotide exerts axon-protective effects, delays axonal degeneration, elevates NAD+ levels, enhances Sirt1 activity, improves myocardial capillary density and alleviates myocardial fibrosis. Nicotinic acid mononucleotide reverses diabetic cardiomyopathy in diabetic mice by increasing myocardial NAD+ levels. Nicotinic acid mononucleotide is applicable to research related to cancer, multiple sclerosis, diabetic cardiomyopathy, neurodegenerative diseases and Huntington's disease[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 321-02-8. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128700. | |
| Nicotinic acid riboside | Nicotinic acid riboside is a NAD+ precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD+ metabolism[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 17720-18-2. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W104368. | |
| Nicotinuric acid | Nicotinuric acid is an acyl glycine. Nicotinuric acid is a metabolite of nicotinic acid. Uses: Scientific research. Category: Signaling pathways. CAS No. 583-08-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 25 g. Product ID: HY-113353. | |
| Nicotinuric acid-d4 | Nicotinuric acid-d4 is the deuterium labeled Nicotinuric acid. Nicotinuric acid is an acyl glycine. Nicotinuric acid is a metabolite of nicotinic acid[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1216737-36-8. Pack Sizes: 5 mg. Product ID: HY-113353S. | |
| Nidanilimab (Nadunolimab) | Nidanilimab (CAN04) is a fully humanized monoclonal anti-IL1RAP antibody with a Kd value of 1.10 pM. Nidanilimab blocks IL1α and IL1β signaling and stimulates the immune system to destroy tumour cells. Nidanilimab can be used in research of non-small lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC) [1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CAN04; Anti-IL-1RAP/IL-1R3 Reference Antibody (nidanilimab). CAS No. 2171061-85-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99379. | |
| Nifedipine | Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY-a-1040. CAS No. 21829-25-4. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B0284. | |
| Niflumic acid | Niflumic acid is a calcium-activated chloride channel blocker and COX-2 inhibitor with the IC50 value of 100 nM. Niflumic acid induces apoptosis through caspase-8/Bid/Bax pathway in lung cancer cells. Niflumic acide exhibits anti-tumor activity by affecting the expression of ERK1/2 and the activity of MMP2 and MMP9. Niflumic acid has orally bioactivity. Niflumic acid acts on rheumatoid arthritis[1][2][3][4][5][6][7][8]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4394-00-7. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-B0493. | |
| Nifuroxazide | Nifuroxazide is an effective inhibitor of STAT3, also exerts potent anti-tumor and anti-metastasis activity. Nifuroxazide is an orally active nitrofuran antibiotic. Uses: Scientific research. Category: Signaling pathways. CAS No. 965-52-6. Pack Sizes: 10 mM * 1 mL in DMSO; 200 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B1436. | |
| Nifurpirinol | Nifurpirinol (P-7138) is a selective prosubstrate of bacterial nitroreductase (NTR). NTR catalyzes the reduction of nifurpirinol to generate cytotoxic metabolites that induce apoptosis in target cells. Nifurpirinol selectively ablates NTR-expressing cells such as pancreatic β cells, osteoblasts, dopaminergic neurons, and podocytes in transgenic zebrafish models. Nifurpirinol can be used in regeneration studies and disease modeling such as focal segmental glomerulosclerosis (FSGS)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: P-7138. CAS No. 13411-16-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135470. | |
| Nigericin | Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin induces pyroptosis through caspase 1/GSDMD in TNBC[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. CAS No. 28380-24-7. Pack Sizes: 10 mM * 1 mL in Ethanol; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-127019. | |
| Nigericin sodium salt | Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. CAS No. 28643-80-3. Pack Sizes: 10 mM * 1 mL in Ethanol; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100381. | |
| Nigerose | Nigerose is a disaccharide[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 497-48-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-148697. | |
| Nikkomycin Z | Nikkomycin Z is a nucleoside peptide and an orally active antifungal agent. Nikkomycin Z inhibits chitin synthesis by acting as a competitive analogue of the chitin synthase substrate UDP-N-acetylglucosamine. Nikkomycin Z has antifungal activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 59456-70-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-19593. | |
| NIK SMI1 | NIK SMI1 is a potent, selective NF-κB inducing kinase (NIK) inhibitor, which inhibits NIK-catalyzed hydrolysis of ATP to ADP with IC50 of 0.23±0.17 nM. NIK SMI1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1660114-31-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112433. | |
| Nile Blue A sulfate | Nile Blue A (Nile blue sulfate) is used to differentiate melanins and lipofuscins. It is also useful for staining fats and preparation of an amperometric glucose sensor[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Nile blue sulfate. CAS No. 3625-57-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-101900. | |
| Nile blue chloride | Nile blue chloride is a highly fluorescent and photostable organic dye. Nile blue chloride and fluorescein isothiocyanate (FITC) can be used to construct a ratiometric pH sensitive probe for tracking the pH of the extracellular fluid between cancer cells in realtime. Nile Blue chloride has the potential for the research of nonlinear optics[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2381-85-3. Pack Sizes: 1 g. Product ID: HY-W110898. | |
| Nile Red | Nile red (Nile blue oxazone) is a lipophilic stain. Nile red has environment-sensitive fluorescence. Nile red is intensely fluorescent in a lipid-rich environment while it has minimal fluorescence in aqueous media. Nile red is an excellent vital stain for the detection of intracellular lipid droplets by fluorescence microscopy and flow cytof uorometry. Nile red stains intracellular lipid droplets red. The fluorescence wavelength is 559/635 nm[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Nile Blue A oxazone; Phenoxazone 9. CAS No. 7385-67-3. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-D0718. | |
| Nile Red (solution) | Nile Red (solution) is a lipophilic stain. Nile red has environment-sensitive fluorescence. Nile red is intensely fluorescent in a lipid-rich environment while it has minimal fluorescence in aqueous media. Nile red is an excellent vital stain for the detection of intracellular lipid droplets by fluorescence microscopy and flow cytof uorometry. Nile red stains intracellular lipid droplets red. The fluorescence wavelength is 559/635 nm[1].Solvent and concentration: DMSO: 1 mM. Uses: Scientific research. Category: Signaling pathways. CAS No. 7385-67-3. Pack Sizes: 500 μL. Product ID: HY-DY1008. | |
| Nilotinib | Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMN107. CAS No. 641571-10-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg. Product ID: HY-10159. | |
| Nilotinib-d6 | Nilotinib-d6 is a deuterium labeled Nilotinib. Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMN107-d6. CAS No. 1268356-17-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-10159S. | |
| Nilotinib monohydrochloride monohydrate | Nilotinib monohydrochloride monohydrate is a second generation tyrosine kinase inhibitor (TKI), is significantly potent against BCR-ABL, and is active against many BCR-ABL mutants. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMN107 monohydrochloride monohydrate. CAS No. 923288-90-8. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10159A. | |
| NIM811 | NIM811 ((Melle-4)cyclosporin; SDZ NIM811) is an orally bioavailable mitochondrial permeability transition and cyclophilin dual inhibitor, which exhibits potent in vitro activity against hepatitis C virus (HCV) [1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (Melle-4)cyclosporin; SDZ NIM811. CAS No. 143205-42-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0025. | |
| Nimbolide | Nimbolide is a triterpene compound that can be isolated from neem (Azadirachta indica), possesses anticancer and antiproliferative activity. Nimbolide induces tumor cell apoptosis by inhibiting NF-κB and CDK4/CDK6 kinase. Nimbolide suppresses the Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 25990-37-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-116035. | |
| Nimesulide | Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R805. CAS No. 51803-78-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B0363. | |
| Nimodipine | Nimodipine (BAY-e 9736) is an orally active, well-tolerated and light-sensitive dihydropyridine calcium antagonist. Nimodipine can be used for the research of cerebrovascular disorders[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY-e 9736. CAS No. 66085-59-4. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g. Product ID: HY-B0265. | |
| Nimotuzumab | Nimotuzumab is a humanized IgG1 monoclonal antibody targeting EGFR with a KD of 0.21 nM. Nimotuzumab is directed against the extracellular domain of the EGFR blocking the binding to its ligands. Nimotuzumab, a strong antitumor agent, is cytolytic on target tumors by its capacity to cause antibody dependent cell mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: h-R3. CAS No. 780758-10-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9968. | |
| Ninerafaxstat | Ninerafaxstat (IMB-1018972) is a novel orally active cardiac mitochondrial drug that restores myocardial energy homeostasis. Ninerafaxstat competitively inhibits 3-ketoacyl-CoA thiolase (3-KAT) to partially suppress fatty acid oxidation, and shifts cardiac energy metabolism from free fatty acid oxidation to glucose oxidation, regulating myocardial substrate utilization and thereby improving cardiac efficiency. Ninerafaxstat can be used for research on cardiovascular diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IMB-1018972; IMB-101. CAS No. 2254741-41-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139577. | |
| Ninerafaxstat trihydrochloride | Ninerafaxstat trihydrochloride (IMB-1018972 trihydrochloride) is the trihydrochloride salt form of Ninerafaxstat (HY-139577). Ninerafaxstat trihydrochloride is a novel orally active cardiac mitochondrial drug that restores myocardial energy homeostasis. Ninerafaxstat trihydrochloride competitively inhibits 3-ketoacyl-CoA thiolase (3-KAT) to partially suppress fatty acid oxidation, and shifts cardiac energy metabolism from free fatty acid oxidation to glucose oxidation, regulating myocardial substrate utilization and thereby improving cardiac efficiency. Ninerafaxstat trihydrochloride can be used for research on cardiovascular diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MB-1018972 trihydrochloride; IMB-101 trihydrochloride. CAS No. 2311824-72-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139577A. | |
| Ninhydrin | Ninhydrin can be used as a chromogenic analytical probe for the quantification of amino acids and proteins. Uses: Scientific research. Category: Signaling pathways. CAS No. 485-47-2. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g; 50 g; 100 g. Product ID: HY-D0908. | |
| Nintedanib | Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BIBF 1120. CAS No. 656247-17-5. Pack Sizes: 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-50904. | |
| Nintedanib-d8 | Nintedanib-d8 is deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BIBF 1120-d8. CAS No. 1624587-87-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-50904S2. | |
| Nintedanib esylate | Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BIBF 1120 esylate. CAS No. 656247-18-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-11106. | |
| Nipocalimab | Nipocalimab (M281) is a fully humanized, recombinant, and non-glycosylated IgG1 monoclonal antibody. Nipocalimab can bind to the IgG-binding site of FcRn with high affinity and inhibit the transplacental transfer of IgG. Nipocalimab can be used in the research of fetal and neonatal hemolytic disease, myasthenia gravis, and various IgG-mediated autoimmune diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: M281. CAS No. 2211985-36-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99037. | |
| NIR-797-isothiocyanate | NIR-797-isothiocyanate is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells. Uses: Scientific research. Category: Signaling pathways. CAS No. 152111-91-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-D0134. | |
| Niraparib | Niraparib (MK-4827) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-4827. CAS No. 1038915-60-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-10619. | |
| Niraparib hydrochloride | Niraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib hydrochloride leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-4827 hydrochloride. CAS No. 1038915-64-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10619A. | |
| Niraparib metabolite M1 | Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Niraparib carboxylic acid metabolite M1; M1 metabolite of niraparib. CAS No. 1476777-06-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-G0023. | |
| Niraparib (R-enantiomer) | Niraparib R-enantiomer (MK-4827 R-enantiomer) is an excellent PARP1 inhibitor with IC50 of 2.4 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK 4827 (R-enantiomer). CAS No. 1038915-58-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10619D. | |
| Niraparib tosylate | Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively. Niraparib tosylate leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-4827 tosylate. CAS No. 1038915-73-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-10619B. | |
| Niraparib tosylate hydrate | Niraparib (MK-4827) tosylate hydrate is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib tosylate hydrate leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-4827 tosylate hydrate. CAS No. 1613220-15-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10619E. | |
| Nirmatrelvir | Nirmatrelvir (PF-07321332) is a potent and orally active SARS-CoV 3C-like protease (3CLPRO) inhibitor. Nirmatrelvir (PF-07321332) targets to the SARS-CoV-2 virus and can be used for COVID-19 research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-07321332. CAS No. 2628280-40-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138687. | |
| Nirmatrelvir-d9 | Nirmatrelvir-d9 (PF-07321332-d9) is the deuterium labeled Nirmatrelvir (HY-138687)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-07321332-d9. CAS No. 2861202-76-6. Pack Sizes: 1 mg. Product ID: HY-138687S. | |
| Nirogacestat | Nirogacestat (PF-3084014) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-3084014. CAS No. 1290543-63-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15185. | |
| Nirogacestat dihydrobromide | Nirogacestat dihydrobromide (PF-3084014 dihydrobromide) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat dihydrobromide while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-3084014 dihydrobromide; PF-03084014 dihydrobromide. CAS No. 1962925-29-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15185B. | |
| Nirogacestat (Standard) | Nirogacestat (Standard) is the analytical standard of Nirogacestat. This product is intended for research and analytical applications. Nirogacestat (PF-3084014) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-3084014 (Standard). CAS No. 1290543-63-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15185R. | |
| Nirsevimab | Nirsevimab (MEDI8897) is a recombinant monoclonal antibody against human respiratory syncytial virus (RSV). Nirsevimab has neutralizing activity against RSV A and RSV B viruses, with IC50 values of 5.42 ng/mL and 9.71 ng/mL, respectively. Nirsevimab can be used for research on respiratory infections[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MEDI8897. CAS No. 1989556-22-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99756. | |
| Nisevokitug | Nisevokitug (NIS-793) is a human, IgG2λ antibody targeting TGF-β (TGFB1/TGFB2). Nisevokitug is expressed by CHO-K1 cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NIS-793. CAS No. 2649854-92-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P990009. | |
| Nisin | Nisin is a bacteriocin produced by a group of Gram-positive bacteria that belongs to Lactococcus and Streptococcus species. Nisin has antibacterial and anti-inflammatory activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1414-45-5. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-P1607. | |
| Nisin Z | Nisin Z is an antimicrobial and anti-inflammatory peptide. Nisin Z is effective against Gram-positive bacteria and fungi, such as C. albicans[1][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 137061-46-2. Pack Sizes: 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-P3466. | |
| N-Isobutyrylglycine | N-Isobutyrylglycine is a Glycine (HY-Y0966) derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 15926-18-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-W141928. | |
| N-Isobutyryl-glycine-d7 | N-Isobutyryl-glycine-d7 is the deuterium labeled N-Isobutyryl-glycine[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1330037-23-4. Pack Sizes: 1 mg. Product ID: HY-W141928S. | |
| Nisoldipine | Nisoldipine (BAY-k 5552; Sular) is an orally active and blood-brain barrier-penetrating dihydropyridine calcium antagonist, with greater vascular selectivity than other calcium channel antagonists. Nisoldipine inhibits calcium influx and blocks voltage-gated calcium channels. Nisoldipine dilates coronary and systemic arteries. Nisoldipine has antihypertensive and anti-anginal activity. Nisoldipine also displays neuroprotective and antiviral activity[1][2][7][11]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY-k 5552. CAS No. 63675-72-9. Pack Sizes: 100 mg; 500 mg; 1 g. Product ID: HY-17402. | |
| Nisoldipine (Standard) | Nisoldipine (Standard) is the analytical standard of Nisoldipine. This product is intended for research and analytical applications. Nisoldipine (BAY-k 5552; Sular) is a highly efficient and specific L-type Cav1.2 channel blocker with an IC50 of 10 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY-k 5552 (Standard). CAS No. 63675-72-9. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17402R. | |
| Nisotirostide | Nisotirotide (LY-3457263) is a subcutaneous injectable NPY2 receptor agonist. By mimicking peptide YY (PYY), Nisotirotide inhibits appetite and can be used in the research of diseases such as obesity and diabetes[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY-3457263. CAS No. 2663844-45-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10026. | |
| Nisoxetine | Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine is an antidepressant and local anesthetic, it can block voltage-gated sodium channels[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 53179-07-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1704. | |
| Nisoxetine hydrochloride | Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine hydrochloride is an antidepressant and local anesthetic, it can block voltage-gated sodium channels[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 57754-86-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1704A. | |
| Nitazoxanide | Nitazoxanide (NTZ), an anthelmintic agent, exhibits a broad spectrum of activities against a wide variety of helminths, protozoa, and enteric bacteria infecting animals and humans. Nitazoxanide inhibits Giardia lamblia trophozoite proliferation in axenic culture with an IC50 of 2.4 μM[1]. Nitazoxanide can be used for the research of parasitic gastroenteritis. Nitazoxanide shows anti-Japanese encephalitis virus (JEV) activity in a mouse model[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NTZ; NSC 697855. CAS No. 55981-09-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-B0217. | |
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