MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Nemvaleukin alfa | Nemvaleukin alfa (ALKS 4230) is a IL-2 fusion protein that selectively binds to intermediate-affinity IL-2R. Nemvaleukin alfa is an activator of NK and effector T cells. Nemvaleukin alfa can be used for research of cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALKS 4230; RDB-1450. CAS No. 2315268-27-8. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-P99752. |  |
| NEO2734 | NEO2734 (EP31670) is an orally active dual p300/CBP and BET bromodomain selective inhibitor, with IC50 values of <30 nM for both p300/CBP and BET bromodomains[1]. NEO2734 is active in SPOP mutant and wild-type prostate cancer[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EP31670. CAS No. 2081072-29-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-136938. | |
| Neoandrographolide | Neoandrographolide is a diterpenoid compound isolated from Andrographis paniculata. Neoandrographolide inhibits osteoclasts differentiation and bone resorption through inhibition of MAPK/NF-κB/PI3K/AKT/GSK3β/PPAR/CAMK signaling pathway. Neoandrographolide inhibits apoptosis in rat embryonic ventricular cardiomyocytes. Neoandrographolide inhibits iNOS and the generation of ROS, activates eNOS, exhibiting anti-inflammatory and hypolipidemic activity[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Neoandrographiside. CAS No. 27215-14-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0721. | |
| Neoanhydropodophyllol | Neoanhydropodophyllol is a cyclolignan derivative, with antineoplastic activity. Neoanhydropodophyllol displays cytotoxicity against several cancer cells (leukemia, lung carcinoma and colon carcinoma)[1]. Uses: Scientific research. Category: Natural products. CAS No. 62287-47-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N7651. | |
| Neocarzilin A | Neocarzilin A (NCA) reduces BST-2 levels via lysosomal degradation. Neocarzilin A has antimigratory and antiproliferative effects on cancer cells. Neocarzilin A inhibits cancer cell migration via irreversible binding to the synaptic vesicle membrane protein VAT-1[1][2]. Uses: Scientific research. Category: Natural products. Alternative Names: NCA. CAS No. 124958-29-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-125900. | |
| Neochamaejasmin B | Neochamaejasmin B is a biflavanone compound. Neochamaejasmin B is isolated from Stellera chamaejasme L. (Thymelaeaceae). Neochamaejasmin B has the cis-trans geometry at the C-2/C-3 and C-2"/C-3" positions[1]. Uses: Scientific research. Category: Natural products. Alternative Names: (+)-Neochamaejasmin B. CAS No. 90411-12-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N3205. | |
| Neochlorogenic acid | Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation. Uses: Scientific research. Category: Signaling pathways. Alternative Names: trans-5-O-Caffeoylquinic acid. CAS No. 906-33-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0722. | |
| Neocuproine | Neocuproine is an organic compound commonly used as a complexing reagent and copper ion detector. It can form stable complexes with copper ions, and can play a catalytic role in certain chemical reactions and analytical methods. In addition, this compound is also widely used in some biomedical fields, such as in the study of copper metabolism disorders and neurodegenerative diseases. Uses: Scientific research. Category: Signaling pathways. CAS No. 484-11-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g. Product ID: HY-W004563. | |
| Neodiosmin | Neodiosmin is a flavone glycoside isolated from the leaves of Citrus aurantium[1]. Uses: Scientific research. Category: Natural products. CAS No. 38665-01-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N4122. | |
| Neoeriocitrin | Neoeriocitrin is a Naringin (HY-N0153) analogue found in Drynaria Rhizome. Neoeriocitrin induces cells proliferation, differentiation, up-regulates type I collagen, osteocalcin, and key osteogenic markers, and increases ALP activity. Neoeriocitrin increases expression of Runx2, COL I, OCN and Beclin1. Neoeriocitrin inhibits phosphorylation of P38 mitogen-activated protein kinase, reduces acetylcholinesterase (AChE) activity, and increases choline acetyltransferase (ChAT) activity. Neoeriocitrin reduces apoptosis and induces autophagy. Neoeriocitrin can be used for the researches of osteoporosis and Alzheimer's disease[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 13241-32-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N4119. | |
| Neohesperidin | Neohesperidin is a flavonoid compound abundant in citrus plants with antioxidant and anti-inflammatory effects. Neohesperidin can upregulate the Wnt/β-catenin signaling pathway, enhance the nuclear translocation of β-catenin and the differentiation of bone marrow stromal cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hesperetin 7-O-neohesperidoside. CAS No. 13241-33-3. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-N0101. | |
| neo-Inositol | neo-Inositol, a stereoisomer of inositol, has been isolated from calf brain[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 488-54-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-121962. | |
| Neoisoliquiritin | Neoisoliquiritin is a bioactive component isolated from Glycyrrhiza uralensis[1]. Uses: Scientific research. Category: Natural products. Alternative Names: Neoisoliquiritigenin. CAS No. 59122-93-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-N2122. | |
| Neomycin sulfate | Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both the nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. Neomycin sulfate inhibits IP3-mediated Ca2+ release, MgATP-dependent Ca2+ uptake, and electrical excitation-evoked skeletal muscle Ca2+ transients. Neomycin sulfate depletes gut microbiota in specific mouse models, causes hearing impairment, and kidney damage with prolonged exposure. Neomycin sulfate can be used for the research of cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1405-10-3. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B0470. | |
| Neomycin sulfate (Standard) | Neomycin (sulfate) (Standard) is the analytical standard of Neomycin (sulfate). This product is intended for research and analytical applications. Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1405-10-3. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-B0470R. | |
| Neophytadiene | Neophytadiene is a diterpene found in Turbinaria ornate, with anti-inflammatory antioxidant and cardioprotective properties[1]. Uses: Scientific research. Category: Natural products. CAS No. 504-96-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N8534. | |
| Neopterin | Neopterin is an immune system activator metabolized by GTP and can be produced by activated macrophages. Neopterin has the potential to resist vascular inflammation and atherosclerosis. Neopterin inhibits the phosphorylation of NF-κB and promotes the expression of PPAR-γ, thereby suppressing the inflammatory response of vascular endothelial cells, reducing the formation of macrophage foam cells, and regulating the migration and proliferation of vascular smooth muscle cells. Neopterin can be used in research fields such as cardiovascular diseases (such as atherosclerosis), inflammation-related diseases and tumor immunomonitoring[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-(+)-Neopterin; D-erythro-Neopterin. CAS No. 2009-64-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W040055. | |
| Neopterin-13C5 | Neopterin-13C5 (D-(+)-Neopterin-13C5; D-erythro-Neopterin-13C5) is the deuterium labeled Neopterin (HY-W040055)[1]. Neopterin (D-(+)-Neopterin), a catabolic product of guanosine triphosphate (GTM), serves as a marker of cellular immune system activation[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-(+)-Neopterin-13C5; D-erythro-Neopterin-13C5. CAS No. 1217632-04-6. Pack Sizes: 1 mg. Product ID: HY-W040055S. | |
| Neopterin (Standard) | Neopterin (Standard) is the analytical standard of Neopterin. This product is intended for research and analytical applications. Neopterin (D-(+)-Neopterin), a catabolic product of guanosine triphosphate (GTM), serves as a marker of cellular immune system activation. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-(+)-Neopterin (Standard); D-erythro-Neopterin (Standard). CAS No. 2009-64-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W040055R. | |
| Neoruscogenin | Neoruscogenin, a member of the steroidal sapogenin family, is a high-affinity agonist of the nuclear receptor RORα (NR1F1) (EC50 = 0.11 μM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 17676-33-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2253. | |
| Neoseptin 3 | Neoseptin 3 is a Toll-like receptor 4/myeloid differentiation factor 2 (mTLR4/MD-2) agonist with an EC50 of 18.5 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1622863-21-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00435. | |
| Neotame | Neotame is a derivative of Aspartame (HY-B0361) and is a flavor enhancer and low-caloric, non-nutritive, high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame causes intestinal epithelial cell death at high concentrations. Neotame induces Apoptosis of Caco-2 cells[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 165450-17-9. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-W011053. | |
| NEP(1-40) | NEP(1-40) is a Nogo-66 receptor (NgR) antagonist peptide, reversing the injury-induced shift in distribution of microglia morphologies by limiting myelin-based inhibition[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 475221-20-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1242. | |
| Nepicastat hydrochloride | Nepicastat hydrochloride (SYN-117 hydrochloride) is a selective, potent, and orally active inhibitor of dopamine-beta-hydroxylase. Nepicastat hydrochloride produces concentration-dependent inhibition of bovine (IC50=8.5 nM) and human (IC50=9 nM) dopamine-beta-hydroxylase. Nepicastat hydrochloride can cross the blood-brain barrier (BBB)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SYN-117 hydrochloride; RS-25560-197 hydrochloride. CAS No. 170151-24-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13289A. | |
| Nepitrin | Nepitrin, isolated from Scrophularia striata, possess significant anti-inflammatory and anti-arthritic activity[1][2]. Uses: Scientific research. Category: Natural products. Alternative Names: Nepetin-7-glucoside. CAS No. 569-90-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N5010. | |
| Neplanocin A | Neplanocin A ((-)-Neplanocin A) is an antitumor antibiotic with significant antitumor activity against murine L1210 leukemia. Neplanocin A is also an irreversible inhibitor of AdoHcy hydrolase (Ki=8.39 nM). Neplanocin A also has antiviral activity and is effective against vaccinia virus. Neplanocin A is obtained from Ampulariella regularis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Neplanocin A. CAS No. 72877-50-0. Pack Sizes: 10 mM * 1 mL in DMSO; 500 μg; 1 mg; 5 mg. Product ID: HY-130430. | |
| Nε-(Carboxymethyl)-L-lysine | Nε-(Carboxymethyl)-L-lysine (CML) is an orally active advanced glycation end product. Nε-(Carboxymethyl)-L-lysine upregulates the expression of PLK1 and CEP20, and induces the activation of RAGE and ERK/NFκB. Nε-(Carboxymethyl)-L-lysine drives centrosome amplification. Nε-(Carboxymethyl)-L-lysine induces malignant transformation of hepatocytes and promotes the development of hepatocellular carcinoma. Nε-(Carboxymethyl)-L-lysine induces epithelial-mesenchymal transition in osteosarcoma cells and enhances their migration and invasion properties[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CML; N6-(Carboxymethyl)-L-lysine; Nε-(1-Carboxymethyl)-L-lysine. CAS No. 5746-4-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W286743. | |
| Nε,Nε,Nε-Trimethyllysine chloride | Nε,Nε,Nε-Trimethyllysine chloride serves as a precursor for gut flora-dependent formation of N,N,N-trimethyl-5-aminovaleric acid (TMAVA)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ne-(Trimethyl)-L-lysine chloride; H-Lys(Me)3-OH chloride. CAS No. 55528-53-5. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N7404. | |
| N-ε-propargyloxycarbonyl-L-lysine | N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) is a lysine-based unnatural amino acid (UAA). N-ε-propargyloxycarbonyl-L-lysine is widely used for bio-conjugation of fluorescent probes in diverse organisms from E. coli to mammalian cells even in animals[1][2]. N-ε-propargyloxycarbonyl-L-lysine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: H-L-Lys(Poc)?-OH. CAS No. 1215204-46-8. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139014. | |
| N-ε-propargyloxycarbonyl-L-lysine hydrochloride | N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) hydrochloride is a lysine-based unnatural amino acid (UAA). N-ε-propargyloxycarbonyl-L-lysine is widely used for bio-conjugation of fluorescent probes in diverse organisms from E. coli to mammalian cells even in animals[1][2]. N-ε-propargyloxycarbonyl-L-lysine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: H-L-Lys(Poc)?-OH hydrochloride. CAS No. 1428330-91-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128676. | |
| Nerandomilast | Nerandomilast (BI 1015550) is an orally active inhibitor of PDE4B with an IC50 value of 7.2 nM. Nerandomilast has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BI 1015550. CAS No. 1423719-30-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153192. | |
| Neratinib | Neratinib (HKI-272) is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HKI-272. CAS No. 698387-09-6. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-32721. | |
| Neratinib maleate | Neratinib (HKI-272) maleate is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HKI-272 maleate. CAS No. 915942-22-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-32721B. | |
| Neratinib (Standard) | Neratinib (Standard) is the analytical standard of Neratinib. This product is intended for research and analytical applications. Neratinib (HKI-272) is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HKI-272 (Standard). CAS No. 698387-09-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-32721R. | |
| Neriifolin | Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[1][2. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 17β-Neriifolin. CAS No. 466-07-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N8441. | |
| Nervonic acid | Nervonic acid is a monounsaturated fatty acid with oral activity. Nervonic acid exerts anti-inflammatory activity by inhibiting NF-κB signaling. Nervonic acid can be used in the study of neurodegenerative diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Selacholeic acid; cis-15-Tetracosenoic acid. CAS No. 506-37-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-N2526. | |
| Nesiritide | Nesiritide (Brain Natriuretic Peptide-32 human) is a recombinant human B-type natriuretic peptide. Nesiritide is a NPRs agonist, with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively. Nesiritide regulates V1/2 activation/inactivation of the L-type calcium channel. Nesiritide shows vasodilatory, diuretic, and natriuretic activities. Nesiritide is used in cardiovascular diseases such as heart failure and vascular remodeling after arterial injury[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Brain Natriuretic Peptide-32 human; BNP-32. CAS No. 124584-08-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0003. | |
| Nesuparib | Nesuparib (JPI-547) is the orally active inhibitor for PARP 1/2 and Tankyrase 1/2 that inhibits tankyrases 1, tankyrases 2, and PARP 1 with IC50s of 5, 1 and 2 nM, respectively. Nesuparib exhibits antitumor activity and can be used in research of advanced solid tumor[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JPI-547/OCN-201. CAS No. 2055357-64-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145584. | |
| Nesvacumab | Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Angiopoietin-2 (Ang2) with high affinity, but shows no binding to Ang1. Nesvacumab can be used in vascular researches[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1296818-77-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99036. | |
| Netarsudil | Netarsudil (AR-13324) is a competitive inhibitor of Rho-associated protein kinases (ROCK I and ROCK II) and a reversible inhibitor of the norepinephrine transporter (NET). Netarsudil reduces intraocular pressure by inhibiting ROCK, causing relaxation of trabecular meshwork cells and dilation of episcleral veins, thereby increasing the ease of aqueous humor outflow, while inhibiting NET to reduce aqueous humor production. Netarsudil is mainly used in the study of ocular hypertension and primary open-angle glaucoma[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AR-13324. CAS No. 1254032-66-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12798. | |
| Netarsudil dimesylate | Netarsudil (AR-13324) dimesylate is a competitive inhibitor of Rho-associated protein kinases (ROCK I and ROCK II) and a reversible inhibitor of the norepinephrine transporter (NET). Netarsudil dimesylate reduces intraocular pressure by inhibiting ROCK, causing relaxation of trabecular meshwork cells and dilation of episcleral veins, thereby increasing the ease of aqueous humor outflow, while inhibiting NET to reduce aqueous humor production. Netarsudil dimesylate is mainly used in the study of ocular hypertension and primary open-angle glaucoma[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AR-13324 dimesylate. CAS No. 1422144-42-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12798A. | |
| Netarsudil hydrochloride | Netarsudil (AR-13324) hydrochloride is a competitive inhibitor of Rho-associated protein kinases (ROCK I and ROCK II) and a reversible inhibitor of the norepinephrine transporter (NET). Netarsudil hydrochloride reduces intraocular pressure by inhibiting ROCK, causing relaxation of trabecular meshwork cells and dilation of episcleral veins, thereby increasing the ease of aqueous humor outflow, while inhibiting NET to reduce aqueous humor production. Netarsudil hydrochloride is mainly used in the study of ocular hypertension and primary open-angle glaucoma[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AR-13324 hydrochloride. CAS No. 1253952-02-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12798B. | |
| N-Ethylmaleimide | N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC50 value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NEM. CAS No. 128-53-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-D0843. | |
| N-Ethylmaleimide-d5 | N-Ethylmaleimide-d5 is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor[1]. N-ethylmaleimide specific inhibits phosphate transport in mitochondria[2]. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NEM-d5. CAS No. 360768-37-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-D0843S. | |
| N-Ethyl-N-nitrosourea | N-Ethyl-N-nitrosourea (ENU) is a DNA alkylating agent. N-Ethyl-N-nitrosourea induces leukemia by alkylating nucleobases, disrupting DNA, and resulting in bone marrow suppression and the formation of leukemic cells. N-Ethyl-N-nitrosourea is teratogenic in vivo, inducing tumor formation and paw malformations in pregnant rats. N-Ethyl-N-nitrosourea cause central nervous system (CNS) tumors and genetic disorders[1][2]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: ENU; N-Nitroso-N-ethylurea. CAS No. 759-73-9. Pack Sizes: 250 mg; 1 g; 5 g; 10 g. Product ID: HY-W019815. | |
| Netilmicin sulfate | Netilmicin (Sch 20569) sulfate is a broad-spectrum semisynthetic aminoglycoside antibiotic. Netilmicin sulfate exhibits antibacterial activity against aminoglycoside-susceptible gram-negative strains and aminoglycoside-resistant strain, such as Escherichia coli, Pseudomonas aeruginosa, Proteus, Staphylococcus aureus, Streptococcus, Serratia, and Enterobacter, with MIC of 0.125-8 μg/mL[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SCH-20569 sulfate. CAS No. 56391-57-2. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0086. | |
| Netropsin dihydrochloride | Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder) and antibiotic, inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei. Netropsin dihydrochloride has antibacterial and antiviral activity[1][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 18133-22-7. Pack Sizes: 1 mg. Product ID: HY-N6800A. | |
| Netupitant | Netupitant (CID-6451149) is a highly potent, selective and orally active neurokinin-1 (NK1) receptor antagonist with a Ki of 0.95 nM for hNK1 in CHO cells. Netupitant has antiemetic affect[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CID 6451149. CAS No. 290297-26-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16346. | |
| NEU3-IN-1 | NEU3-IN-1 (compound 963) is a NEU3 inhibitor (Ki: 0.12 μM; IC50: 0.31 μM) based on the 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) scaffold and is a C9 biphenylcarbamate derivative. NEU is a human neuraminidase with 4 isozymes; NEU3-IN-1 is an important tool for studying the function of NEU3 isozymes; its amide and triazole linker analogs are selective for NEU1 and NEU4 isozymes, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3094051-91-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161943. | |
| Neuraminidase, Microorganism | Neuraminidase, Microorganism (Exo-α-sialidase) is an exosialidase, is often used in biochemical studies. Neuraminidase cleaves α-ketosidic linkage between the sialic (N-acetylneuraminic) acid and an adjacent sugar residue. Neuraminidase, derived from mucosal pathogens, is a virulence factor that modifies the host's response to infection[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Exo-α-sialidase. CAS No. 9001-67-6. Pack Sizes: 5 U; 10 U. Product ID: HY-P2988. | |
| Neurokinin A | Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Substance K; Neurokinin α; Neuromedin L; NKA. CAS No. 86933-74-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0197. | |
| Neurokinin B | Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 86933-75-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0242. | |
| Neurokinin B TFA | Neurokinin B TFA belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 101536-55-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0242A. | |
| Neuromedin B | Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals. Uses: Scientific research. Category: Signaling pathways. CAS No. 87096-84-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0241. | |
| Neuromedin N | Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Neuromedin N (rat, mouse, porcine, canine). CAS No. 92169-45-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P0079. | |
| Neuronostatin-13 (human) | Neuronostatin-13 human is a 13-amino acid peptide hormone encoded by the somatostatin gene and plays an important role in the regulation of hormonal and cardiac function. Uses: Scientific research. Category: Signaling pathways. CAS No. 1096485-24-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1373. | |
| Neuropathiazol | Neuropathiazol, a neuronal differentiation inducer, selectively induces neuronal differentiation of multipotent hippocampal neural progenitor cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 880090-88-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10591. | |
| Neuropeptide FF | Neuropeptide FF (NPFF), an octapeptide belonging to the RF-amide family of peptides, is a NPFF1 and NPFF2 receptors agonist with Ki values of 2.82 nM and 0.21 nM, respectively. Neuropeptide FF induces abstinence syndrome, exerts antiopioid and analgesic effects, releases via calcium-dependent mechanisms from rat spinal cord, regulates memory, autonomic function, and neuroendocrine function, modulates pain and opioid antinociception, reduces food intake, stimulates water intake, alters cardiovascular parameters, and shows differential activity in hypothalamic paraventricular nucleus neurons. Neuropeptide FF is present in mammalian central nervous system and periphery, with NPFF-immunoreactivity increases in rat cerebrospinal fluid during opiate tolerance, and its NPFF gene and NPFF-R2 gene are up-regulated in rat spinal cord and dorsal root ganglia during peripheral inflammation. Neuropeptide FF can be used for the research of opioid tolerance, morphine-induced analgesia, abstinence syndrome, pain, hypertension, nociception, inflammatory pain, and neuropathic pain[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NPFF. CAS No. 99566-27-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1248. | |
| Neuropeptide S (human) | Neuropeptide S human, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human can be used for Alzheimer's disease (AD) research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 412938-67-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1389. | |
| Neuropeptide W-23 (human) | Neuropeptide W-23 (human) (NPW-23), the active form of Neuropeptide W, is an endogenous agonist of NPBW1 (GPR7) and NPBW2 (GPR8)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NPW-23. CAS No. 383415-79-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1035. | |
| Neuropeptide Y(29-64) | Neuropeptide Y(29-64) is a 36 amino acid peptide, a fragment of Neuropeptide Y. Uses: Scientific research. Category: Signaling pathways. CAS No. 303052-45-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1601. | |
| Neuropeptide Y (3-36) (human, rat) | Neuropeptide Y (3-36) (human, rat) is a neuropeptide Y fragment derived from humans or rats. Neuropeptide Y is an extremely abundant neurotransmitter in central and peripheral neurons, and it participates in the regulation of psychomotor activity, circadian rhythm, feeding behavior and cardiovascular function. Neuropeptide Y (3-36) (human, rat) can serve as a substrate to be sequentially degraded from its N-terminus by AfuS28, and it requires binding to AfuS28 and SedB to be decomposed into amino acids, dipeptides and tripeptides[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 150138-78-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2543. | |
| Neuropeptide Y (human,rat,mouse) | Neuropeptide Y (human,rat,mouse) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Neuropeptide Y (29-64), amide. CAS No. 90880-35-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0198. | |
| Neurotensin | Neurotensin, a gut tridecapeptide, acts as a potent cellular mitogen for various colorectal and pancreatic cancers which possess high-affinity neurotensin receptors (NTR). Uses: Scientific research. Category: Signaling pathways. CAS No. 39379-15-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0234. | |
| Neurotensin(8-13) | Neurotensin (8-13) is an active fragment of Neurotensin. Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density. Uses: Scientific research. Category: Signaling pathways. CAS No. 60482-95-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0251. | |
| Neutral protease I | Neutral protease I (Dispase I) is a rapid, effective, gentle and neutral protease that can separate intact epidermis from the dermis. Neutral protease I can also separate intact epithelial sheets in culture from the substratum. Neutral protease I preserves the viability of the epithelial cells while cleaving the basement membrane zone region. Neutral protease I can also be used to prevent clumping in suspension cultures. Neutral protease I cleaves fibronectin and type IV collagen, but not laminin, type V collagen, serum albumin, or transferrin[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dispase I. CAS No. 42613-33-2. Pack Sizes: 1 mg. Product ID: HY-131577A. | |
| Neutral protease, Paenibacillus polymyxa | Neutral protease, Paenibacillus polymyxa (Dispase II, Dispase) is a neutral protease and potent fibronectinase and type IV collagenase. Neutral protease, Paenibacillus polymyxa can be used to separate the intact epidermis from the dermis and intact epithelial sheets in culture from the substratum[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dispase II, Dispase. CAS No. 42613-33-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131577. | |
| Neutral Red | Neutral Red, a nitrogenous pH-indicator with a pKi of 6.8, is an indicator for the internal acidification of thylakoids. Neutral Red stains lysosomes red[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 553-24-2. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-D0166. | |
| Neutrophil elastase inhibitor 1 | Neutrophil elastase inhibitor 1 (Compound 5b) is a competitive, pseudoirreversible inhibitor for neutrophil elastase with an IC50 of 7 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1448314-31-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-118177. | |
| Neutrophil elastase inhibitor 5 | Neutrophil elastase inhibitor 5 (compound 29) is a dual inhibitor of HNE (human neutrophil elastase) and proteinase 3 (PR3) with IC50 values of 4.91 μM and 20.69 μM, respectively. Neutrophil elastase inhibitor 5 can be used in the study of neutrophil inflammatory diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3020696-44-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155414. | |
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