MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| N6,N6-Dimethyladenosine | N6,N6-Dimethyladenosine, a modified ribonucleoside, is an endogenous A3 adenosine receptor ligand. N6,N6-Dimethyladenosine is an AKT inhibitor with antitumor effects. N6, N6-Dimethyladenosine targets SARS-CoV-2 entry protein ADAM17. N6, N6-Dimethyladenosine robustly inhibits AKT signaling in a variety of non-small cell lung cancer cell lines[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2620-62-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101984. |  |
| (-)-N6-Phenylisopropyl adenosine | (-)-N6-phenylisopropyl adenosine (L-Phenylisopropyladenosine) is a selective A1 adenosine receptor agonist. (-)-N6-phenylisopropyl adenosine inhibits K+-induced Ca2+ uptake with an IC50 value of 0.5 μM. (-)-N6-phenylisopropyl adenosine protects against ischemia-induced ventricular arrhythmias and atrial fibrillation, and exacerbates ethanol withdrawal symptoms. (-)-N6-phenylisopropyl adenosine also has analgesic effects[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: L-Phenylisopropyladenosine; L-PIA; R-PIA. CAS No. 38594-96-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-136661. | |
| N8-Acetylspermidine dihydrochloride | N8-Acetylspermidine dihydrochloride is a polyamine metabolite. N8-Acetylspermidine dihydrochloride can be oxidatively deaminated by copper amine oxidase. N8-Acetylspermidine dihydrochloride can also induce the differentiation of PC12 cells and promote neurite outgrowth[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 34450-15-2. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113253A. | |
| N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N-methyl-S-trityl-L-cysteine | N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N-methyl-S-trityl-L-cysteine is a cysteine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 944797-51-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 25 g. Product ID: HY-W036322. | |
| N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(phenylmethyl)-L-serine | N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(phenylmethyl)-L-serine is a serine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 83792-48-7. Pack Sizes: 10 mM * 1 mL in DMSO; 10 g; 25 g; 100 g. Product ID: HY-W008977. | |
| N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-trityl-L-homocysteine | N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-trityl-L-homocysteine is a cysteine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 167015-23-8. Pack Sizes: 10 mM * 1 mL in DMSO; 250 mg; 1 g; 5 g; 10 g. Product ID: HY-W048918. | |
| NA-014 | NA-014 is an excitatory amino acid transporter 2 (EAAT2)-selective positive allosteric modulator. NA-014 increases EAAT2-mediated glutamate uptake. NA-014 can be used for the research of epilepsy, neuropathic pain, stroke, drugs of abuse disorders[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3041127-59-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162455. | |
| NA-184 | NA-184 is a selective and brain-penetrant calpain-2 inhibitor with an IC50 of 134 nM for mouse calpain-2. NA-184 has weak inhibitory activity on calpain-1 (IC50 of 2826 nM). NA-184 does not exhibit significant inhibition on a variety of other cysteine-, serine- or metallo-proteases. NA-184 shows significant neuroprotection and can be used for the study of traumatic brain injury (TBI)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2688119-39-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-155482. | |
| Naa50-IN-1 | Naa50-IN-1 is an N-alpha-acetyltransferase 50 (Naa50) inhibitor with an IC50 of 7 nM against the human protein. Naa50-IN-1 exhibits selectivity toward the related enzymes Naa10 and Naa60. Naa50-IN-1 binds to the substrate-binding pocket of Naa50, and its binding affinity is enhanced by AcCoA[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2522920-65-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156140. | |
| NAAA-IN-1 | NAAA-IN-1 (Compound 1) is a potent and selective inhibitor of NAAA with an IC50 of 7 nM. NAAA is a cysteine amidase which preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). NAAA-IN-1 has the potential for the research of inflammation and pain[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1439366-66-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-147773. | |
| NAB-14 | NAB-14 is a potent, selective, orally active and non-competitive GluN2C/2D antagonists with an IC50 of 580 nM for GluN1/GluN2D. NAB-14 shows >800-fold selective for recombinant GluN2C and GluN2D over GluN2A and GluN2B. NAB-14 can cross the blood-brain-barrier[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1237541-73-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124569. | |
| NAB2 | NAB2 is a neuroprotectant that targets the small GTPase Rab1a. NAB2 selectively binds to the GDP-bound form of Rab1a and protects multiple cell types from α-synuclein toxicity by increasing Rab1a expression. Rab1a regulates ER-to-Golgi trafficking and mediates endosomal trafficking events of the E3 ubiquitin ligase Rsp5/Nedd4. NAB2 stimulates ubiquitination of related proteins in a Nedd4-dependent manner and rescues α-synuclein-associated trafficking defects associated with early-onset Parkinson's disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1504588-00-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110174. | |
| Nabumetone-d3 | Nabumetone-d3 is the deuterium labeled Nabumetone (HY-B0559). Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the proagent of the active metaboliteα-Demethylnaproxen (HY-W086896). Nabumetone can inhibit cancer cells proliferation and relieve gastric ulcers[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BRL14777-d3. CAS No. 1216770-08-9. Pack Sizes: 1 mg. Product ID: HY-B0559S. | |
| N-Acetyl-5-hydroxytryptamine | N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Acetylserotonin; Normelatonin; O-Demethylmelatonin. CAS No. 1210-83-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107854. | |
| N-Acetyl-5-hydroxytryptamine-d3 | N-Acetyl-5-hydroxytryptamine-d3 is the deuterium labeled N-Acetyl-5-hydroxytryptamine. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Acetylserotonin-d3; Normelatonin-d3; O-Demethylmelatonin-d3. CAS No. 2001098-07-1. Pack Sizes: 1 mg. Product ID: HY-107854S. | |
| N-Acetyl-α-D-glucosamine 1-phosphate disodium | N-acetyl-α-d-glucosamine 1-phosphate disodium (GlcNAc-1-P) is an ectopic sugar phosphate and a key intermediate in N-glycoprotein biosynthesis. N-acetyl-α-d-glucosamine 1-phosphate disodium serves as a metabolic precursor of teichoic acid and muramic acid, which are components of bacterial cell walls[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 31281-59-1. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg. Product ID: HY-147063. | |
| N-Acetyl-β-neuraminic acid methyl ester | N-Acetyl-β-neuraminic acid methyl ester (N-Acetyl-Neuraminic acid (Sialic acid)) is an ester compound[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Acetyl-Neuraminic acid (Sialic acid). CAS No. 22900-11-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g. Product ID: HY-75279. | |
| N-Acetylcarnosine | N-Acetylcarnosine, a natural histidine-containing dipeptide, is a source of pharmacological principal L-carnosine. N-Acetylcarnosine is a potent ophthalmic agent in human cataracts[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Acetyl-L-carnosine. CAS No. 56353-15-2. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-133026. | |
| N-Acetylcysteine amide | N-Acetylcysteine amide is a cell membranes and blood brain barrier permeant thiol antioxidant and neuroprotective agent, reduces ROS production. Uses: Scientific research. Category: Signaling pathways. CAS No. 38520-57-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-110256. | |
| N-Acetyl-D-cysteine | N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group, but cannot enter the glutathione metabolic pathway[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 26117-28-2. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-136386. | |
| N-Acetyl-D-glucosamine | N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candida albicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Acetyl-2-amino-2-deoxy-D-glucose. CAS No. 7512-17-6. Pack Sizes: 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-A0132. | |
| N-Acetyl-DL-methionine | N-Acetyl-DL-methionine is an endogenous metabolite. Uses: Scientific research. Category: Signaling pathways. CAS No. 1115-47-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-W019704. | |
| N-Acetyl-D-mannosamine | N-Acetyl-D-mannosamine (ManNAc) is an oral active sialic acid precursor that can prevent hypertension by increasing sialylation of IgG, making it a promising candidate for cardiovascular disease research. Additionally, N-Acetyl-D-mannosamine can activate hypocretin (HCRT) gene expression in orexin neurons and improve neurodegeneration caused by aging, offering potential avenues for research in neurological disorders[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Acetylmannosamine; ManNAc. CAS No. 3615-17-6. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g. Product ID: HY-128850. | |
| N-acetyldopamine | N-acetyldopamine is a sepiapterin reductase inhibitor. N-acetyldopamine is a catecholamine that is used by insects as sclerotizing precursors to harden their cuticle. N-acetyldopamine can attenuate LPS-stimulated TNF-α production and superoxide production in THP-1 cells[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NADA. CAS No. 2494-12-4. Pack Sizes: 100 mg; 250 mg. Product ID: HY-N7493. | |
| N-Acetylglycine-d5 | N-Acetylglycine-d5 (Aceturic acid-d5) is the deuterium labeled N-Acetylglycine (HY-Y0069). N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods. N-Acetylglycine is a flavor enhancer which elicits Monosodium glutamate (MSG)-like sensory experiencesN-Acetylglycine[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Aceturic acid-d5; Acetamidoacetic acid-d5. CAS No. 1219805-82-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-Y0069S. | |
| N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide | N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide (Ac-IEPD-pNA) is a colorimetric peptide substrate of granzyme B that allows accurate measurement of granzyme B activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ac-IEPD-pNA. CAS No. 216757-29-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3236. | |
| N-Acetyllactosamine | N-Acetyllactosamine (N-Acetyl-D-lactosamine), a nitrogen-containing disaccharide, is a galectin-3 inhibitor, which is an important component of various oligosaccharides such as glycoproteins and sialyl Lewis X. N-Acetyllactosamine can be used as the starting material for the synthesis of various oligosaccharides. N-Acetyllactosamine has prebiotic effects[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Acetyl-D-lactosamine. CAS No. 32181-59-2. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126854. | |
| N-Acetyllactosamine-C2-NH2 | N-Acetyllactosamine-C2-NH2 (Compound β-D-Gal-(l-4)-β-D- GlcNAc-(l-4))-l-ethylamine) is a disaccharide compound and is the core backbone component for constructing sialylated glycans (sialosides) [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 799854-49-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-185060. | |
| N-Acetyl-L-aspartic acid | N-Acetyl-L-aspartic acid is a derivative of Aspartic acid (HY-N0666) and endogenous compound. N-Acetyl-L-aspartic acid acts as an acetyl donor. N-Acetyl-L-aspartic acid is involved in brain metabolism. N-Acetyl-L-aspartic acid is used in the research of neurodegenerative diseases (such as Canavan disease)[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 997-55-7. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-113524. | |
| N-Acetyl-L-aspartic acid-d3 | N-Acetyl-L-aspartic acid-d3 is the deuterium labeled N-Acetyl-L-aspartic acid (HY-113524). N-Acetyl-L-aspartic acid is a derivative of Aspartic acid (HY-N0666) and endogenous compound. N-Acetyl-L-aspartic acid acts as an acetyl donor. N-Acetyl-L-aspartic acid is involved in brain metabolism. N-Acetyl-L-aspartic acid is used in the research of neurodegenerative diseases (such as Canavan disease)[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 284665-15-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-113524S. | |
| N-Acetyl-L-cysteine ethyl ester | N-Acetyl-L-cysteine ethyl ester is an esterified form of N-acetyl-L-cysteine (NAC). N-Acetyl-L-cysteine ethyl ester exhibits enhanced cell permeability, and produce NAC and cysteine. N-Acetyl-L-cysteine ethyl ester increases circulating hydrogen sulfide (H2S) and can be used as an H2S producer. N-Acetyl-L-cysteine ethyl ester has the potential to substitute NAC as a mucolytic agent, and as a GSH-related antioxidant[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Acetylcysteine ethyl ester; NACET. CAS No. 59587-09-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134495. | |
| N-Acetyl-L-tyrosine | N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level reactive oxygen species (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 537-55-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g. Product ID: HY-W012382. | |
| N-Acetyl lysyltyrosylcysteine amide | N-Acetyl lysyltyrosylcysteine amide is a potent, reversible, specific, and non-toxic tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO generation of toxic oxidants in vivo. N-Acetyl lysyltyrosylcysteine amide reduces neuronal damage and preserves brain tissue and neurological function in the stroked brain. N-Acetyl lysyltyrosylcysteine amide inhibits MPO-dependent hypochlorous acid (HOCl) generation, protein nitration, and LDL oxidation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1287585-40-3. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg. Product ID: HY-125039. | |
| N-Acetylneuraminic acid | N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NANA; Lactaminic acid. CAS No. 131-48-6. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 1 g; 5 g. Product ID: HY-I0400. | |
| N-Acetylornithine | N-Acetylornithine is a precursor of ornithine. N-Acetylornithine is associated with type 2 diabetes[1][2]. Uses: Scientific research. Category: Natural products. CAS No. 6205-8-9. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg. Product ID: HY-113080. | |
| N-Acetylputrescine | N-Acetylputrescine is a polyamine metabolite that regulates cell proliferation and signal transduction mainly by participating in polyamine acetylation modification. N-Acetylputrescine may reduce the positive charge of polyamines, affect protein-nucleic acid interactions, and promote cell growth. The concentration changes of N-Acetylputrescine can help disease diagnosis (such as early screening and efficacy evaluation of lung cancer) and microbial cell wall structure research. N-Acetylputrescine can be used as a potential biomarker for the progression of squamous cell carcinoma of the lung (SCCL) and Parkinson's disease (PD)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NAP. CAS No. 5699-41-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-W342604. | |
| N-Acetylputrescine hydrochloride | N-Acetylputrescine hydrochloride is a polyamine metabolite that regulates cell proliferation and signal transduction mainly by participating in polyamine acetylation modification. N-Acetylputrescine hydrochloride may reduce the positive charge of polyamines, affect protein-nucleic acid interactions, and promote cell growth. The concentration changes of N-Acetylputrescine hydrochloride can help disease diagnosis (such as early screening and efficacy evaluation of lung cancer) and microbial cell wall structure research. N-Acetylputrescine hydrochloride can be used as a potential biomarker for the progression of squamous cell carcinoma of the lung (SCCL) and Parkinson's disease (PD)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 18233-70-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113100. | |
| N-Acetyl-Sar24 | N-Acetyl-Sar24 is an acetylated derivative of Sarcosine (HY-101037)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2313534-28-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W1116287. | |
| N-Acetyl semax amidate | N-Acetyl semax amidate is a biologically active peptide. N-Acetyl semax amidate can be used for the research of various biochemical studies. Uses: Scientific research. Category: Signaling pathways. CAS No. 2920938-90-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3588. | |
| N-Acetyl-Ser-dAsp-Lys-Pro | N-Acetyl-Ser-dAsp-Lys-Pro, an endogenous tetrapeptide secreted by bone marrow, is a specific substrate for the N-terminal site of ACE. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ac-SdKP. CAS No. 127103-11-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0266. | |
| N-Acetyltaurine | N - acetyltaurine is an orally active endogenous sulfonate that is synthesized from taurine and acetate in the renal cortex. N - acetyltaurine supports bacterial growth as a sole fixed nitrogen or carbon source. N - acetyltaurine buffers acetyl moieties of mitochondrial acetyl - CoA in skeletal muscle. N - acetyltaurine reduces food intake and body weight in obese and lean wild - type mice in a GFRAL - dependent manner. N - acetyltaurine can be used for the research of diet - induced obesity, hyperacetatemia and diabetes[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 19213-70-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W587486. | |
| NAcM-OPT | NAcM-OPT is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor, which potently inhibits the DCN1-UBE2M interaction[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2089293-61-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111505. | |
| Nacubactam | Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and C β-lactamases. Nacubactam acts as a penicillin binding protein (PBP) 2-active antibacterial, and gives β-lactamase-independent potentiation of β-lactams targeting other PBPs. Nacubactam potentiates the antimicrobial activities of Piperacillin (HY-B1923), Cefepime (HY-B0692), and Meropenem (HY-13678) against CTX-M-15-positive Escherichia coli and KPC-positive Klebsiella pneumoniae[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OP0595 free acid. CAS No. 1452458-86-4. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-109008. | |
| NAD+ | NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. Uses: Scientific research. Category: Signaling pathways. Alternative Names: β-DPN; β-NAD; β-Nicotinamide Adenine Dinucleotide. CAS No. 53-84-9. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-B0445. | |
| NADA-green | NADA-green is a fluorescent D-amino acid probe. NADA-green is efficiently incorporated into the peptidoglycan of diverse bacterial species peptidoglycan biosynthesis. NADA-green allows probing of bacterial growth with minimal perturbation[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NADA hydrochloride. CAS No. 2253733-11-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-D1117. | |
| NAD-dependent Glucose dehydrogenase | NAD-dependent glucose dehydrogenase (GDH-NAD) is an oxidoreductase that uses NAD+ as a coenzyme, specifically catalyzes the dehydrogenation of glucose to gluconolactone, and reduces NAD+ to NADH. NAD-dependent glucose dehydrogenase exhibits favorable substrate selectivity and stability, and is not affected by oxygen[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GDH-NAD. CAS No. 9028-53-9. Pack Sizes: 1 KU. Product ID: HY-P3186A. | |
| NAD+ (GMP Like) | NAD+ (GMP Like) is NAD+ (HY-B0445) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. Uses: Scientific research. Category: Signaling pathways. Alternative Names: β-DPN (GMP Like); β-NAD (GMP Like); β-Nicotinamide Adenine Dinucleotide (GMP Like). CAS No. 53-84-9. Pack Sizes: 10 mg; 50 mg; 100 mg. Product ID: HY-B0445GL. | |
| NADH disodium salt | NADH disodium salt (Disodium NADH) is an orally active reduced coenzyme. NADH disodium salt is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH disodium salt plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Disodium NADH. CAS No. 606-68-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-F0001. | |
| NADH disodium salt (Standard) | NADH (disodium salt) (Standard) is the analytical standard of NADH (disodium salt). This product is intended for research and analytical applications. NADH disodium salt (Disodium NADH) is an orally active reduced coenzyme. NADH disodium salt is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH disodium salt plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Disodium NADH (Standard). CAS No. 606-68-8. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-F0001R. | |
| NADI-351 | NADI-351 is an orally active and potent Notch1 inhibitor that selectively disrupts Notch1 transcription complexes and reduces Notch1 recruitment to target genes. NADI-351 can be utilized in cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2503017-11-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164404. | |
| Nadifloxacin | Nadifloxacin (OPC7251) is a broad-spectrum quinolone antibiotic. Nadifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, interfering with DNA replication. It also suppresses the production of proinflammatory cytokines (such as IL-1α, IL-6, and IL-8). Nadifloxacin exhibits antibacterial activity against various pathogens, including Propionibacterium acnes and Staphylococcus aureus. Nadifloxacin also exhibits anti-inflammatory activity. Nadifloxacin can be used in the research of skin infections such as acne vulgaris, folliculitis, and impetigo[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OPC7251. CAS No. 124858-35-1. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g. Product ID: HY-B0506. | |
| Nadolol | Nadolol (SQ-11725) is a non-selective and orally active β-adrenergic receptors blocker and is a substrate of organic anion transporting polypeptide 1A2 (OATP1A2). Nadolol has the the potential for high blood pressure, angina pectoris and vascular headaches research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SQ-11725. CAS No. 42200-33-9. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-B0804. | |
| NADP | NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes[1][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 53-59-8. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-113325. | |
| NADP disodium salt | NADP disodium salt is the disodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes[1][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Disodium NADP. CAS No. 24292-60-2. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg. Product ID: HY-F0002A. | |
| NADPH | NADPH is a coenzyme of glutathione reductase (GR), thioredoxin reductase (TrxR) and NADPH oxidase (NOX), and participates in redox reactions as a hydrogen donor. NADPH has the characteristic of selectively participating in the regulation of cellular redox homeostasis. NADPH exerts antioxidant activity and resists reactive oxygen species (ROS) damage by providing reducing equivalents for the regeneration of glutathione (GSH) and thioredoxin (Trx); at the same time, it acts as a substrate of NOX to generate superoxide anions, mediating oxidative stress and immune response. NADPH participates in maintaining the intracellular reducing environment, biosynthesis and regulating gene expression (such as the Nrf2 pathway), and is mainly used in the study of oxidative stress-related diseases (such as cardiovascular diseases, neurodegenerative diseases, cancer) and immune regulation mechanisms[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 53-57-6. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg. Product ID: HY-113324. | |
| NAD(P)H-Nitrate reductase | NAD(P)H-Nitrate reductase is isolated from Aspergillus niger that catalyses the reduction of nitrate to nitrite via a two-electron transfer. In plants, the electron donor for Nitrate reductase is NADPH is NADH:Nitrate reductase and a bispecific NAD(P)H: Nitrate reductase[1]. Uses: Scientific research. Category: Enzymes. CAS No. 9029-27-0. Pack Sizes: 1 U. Product ID: HY-P2996. | |
| NADPH oxidase-IN-1 | NADPH oxidase-IN-1 is an orally active NADPH oxidase (Nox) inhibitor, related with neuronal inflammation. NADPH oxidase-IN-1 can cross the blood-brain barrier (BBB), inhibits Nox2 and Nox4 with IC50s of 1.9 μM and 2.47 μM, respectively. NADPH oxidase-IN-1 suppresses pro-inflammatory cytokines production and LPS-mediated microglial migration, also has in vivo efficacy[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2762405-17-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152026. | |
| NADPH tetrasodium salt | NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt is an endogenous inhibitor of ferroptosis. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2646-71-1. Pack Sizes: 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-F0003. | |
| NADPH tetrasodium salt (Standard) | NADPH tetrasodium salt (Standard) is the analytical standard of NADPH tetrasodium salt (HY-F0003). This product is intended for research and analytical applications. NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt is an endogenous inhibitor of ferroptosis. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication. Uses: Scientific research. Category: Signaling pathways. CAS No. 2646-71-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-F0003R. | |
| NADP sodium hydrate | NADP sodium hydrate is the sodium salt hydrate form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes[1][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 698999-85-8. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-113325A. | |
| NADP sodium salt | NADP sodium salt is the sodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes[1][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Sodium NADP. CAS No. 1184-16-3. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg. Product ID: HY-F0002. | |
| NAD sodium | NAD sodium is an orally effective cofactor and homeostatic regulator. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions that oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria, which indirectly generates ATP. NAD sodium can be used for the research of non-alcoholic fatty liver disease, obesity, and glucose intolerance[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: β-DPN sodium; β-NAD sodium; β-Nicotinamide Adenine Dinucleotide sodium. CAS No. 20111-18-6. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g. Product ID: HY-B0445A. | |
| NAD sodium (Standard) | NAD sodium (Standard) is the analytical standard of NAD sodium. This product is intended for research and analytical applications. NAD (β-Nicotinamide Adenine Dinucleotide) sodium is an analogue of NAD. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions which oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria that indirectly generates ATP[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: β-DPN sodium (Standard); β-NAD sodium (Standard); β-Nicotinamide Adenine Dinucleotide sodium (Standard). CAS No. 20111-18-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-B0445AR. | |
| NAE-IN-1 | NAE-IN-1 (compound X-10) is a potent NAE1 inhibitor. NAE-IN-1 induces apoptosis and cell cycle arrest at the G2/M phase. NAE-IN-1 increases ROS levels and prevents cell migration. NAE-IN-1 shows anti-proliferation activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3058629-66-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161268. | |
| Nafamostat mesylate | Nafamostat mesylate (FUT-175), an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat mesylate has anticancer and antivirus effect. Nafamostat mesylate induce apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat mesylate can be used in the development of the pathological thickening of the arterial wall[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FUT-175. CAS No. 82956-11-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B0190A. | |
| Nafoxidine | Nafoxidine, a nonsteroidal estrogen antagonist, is shown to possess antitumor activity against breast cancer. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Nafoxidene. CAS No. 1845-11-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145716. | |
| NAI-N3 | NAI-N3 is a RNA acylation reagent that enables RNA purification. NAI-N3 is a dual-function SHAPE (selective 2-hydroxyl acylation and profiling experiment) probe (RNA structure probe and enrichment)[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1612756-29-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103006. | |
| Naldemedine tosylate | Naldemedine (S-297995) tosylate is an orally active μ-opioid receptor antagonist (PAMORA)[1]. Naldemedine tosylate shows potent binding affinities (Ki=0.34, 0.43, 0.94 nM, respectively) and antagonist activities (IC50=25.57, 7.09, 16.1 nM, respectively) for recombinant human μ-, δ-, and κ- opioid receptors[2]. Naldemedine can be used in opioid-induced constipation (OIC) research[2]. Naldemedine tosylate is predicted to bind to 3CLpro encoded by SARS-CoV2 genome[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S-297995 tosylate. CAS No. 1345728-04-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19627A. | |
| Nalidixic acid | Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 389-08-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-B0398. | |
| Nalmefene | Nalmefene is a BBB-penetrable opioid receptor modulator. Nalmefene is an antagonist of MOR and DOR, and a partial agonist of KOR. Nalmefene has anti-inflammatory and neuroprotective activities. Nalmefene can be used in the research of reducing alcohol-dependent disorders[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 55096-26-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107744. | |
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