MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Naloxegol oxalate | Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) is an orally active peripherally acting μ-opioid receptor antagonist with a target Ki of 7.42 nM. Naloxegol oxalate inhibits the binding of opioids to μ-opioid receptors in the gastrointestinal tract, and alleviates opioid-induced gastrointestinal hypomotility, delayed transit, hypertonicity, and increased fluid reabsorption. Naloxegol oxalate is applicable to research related to opioid-induced constipation[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NKTR-118 oxalate; AZ-13337019 oxalate. CAS No. 1354744-91-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0118A. |  |
| Naloxone | Naloxone is an antagonist of Opioid receptor. Naloxone alleviates opioid-overdose-induced respiratory depression. Naloxone may cause pulmonary edema and cardiac arrhythmias[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 465-65-6. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-17417A. | |
| Naloxone hydrochloride | Naloxone hydrochloride is an antagonist of Opioid receptor. Naloxone hydrochloride alleviates opioid-overdose-induced respiratory depression. Naloxone hydrochloride may cause pulmonary edema and cardiac arrhythmias[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 357-08-4. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-17417. | |
| Naloxone hydrochloride (Standard) | Naloxone (hydrochloride) (Standard) is the analytical standard of Naloxone (hydrochloride). This product is intended for research and analytical applications. Naloxone hydrochloride is an antagonist of Opioid receptor. Naloxone hydrochloride alleviates opioid-overdose-induced respiratory depression. Naloxone hydrochloride may cause pulmonary edema and cardiac arrhythmias[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 357-08-4. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17417R. | |
| Nα-Benzoyl-L-arginine 4-nitroanilide hydrochloride | Nα-Benzoyl-L-arginine 4-nitroanilide (hydrochloride) is aarginine derivatives. Uses: Scientific research. Category: Signaling pathways. CAS No. 21653-40-7. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg; 1 g; 5 g. Product ID: HY-137529. | |
| Nα-Benzoyl-L-arginine-7-amido-4-methylcoumarin hydrochloride | Nα-Benzoyl-L-arginine-7-amido-4-methylcoumarin hydrochloride is a biochemical assay reagent. Uses: Scientific research. Category: Signaling pathways. CAS No. 83701-04-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-137887. | |
| Nα,Nα-Bis(carboxymethyl)-L-lysine | Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 113231-05-3. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g; 5 g; 10 g; 25 g; 100 g. Product ID: HY-100047. | |
| Naltrexone | Naltrexone is an orally active, long-acting opioid receptor (opioid receptor) antagonist. Naltrexone blocks the euphoric effects of exogenous opioids and reduces alcohol craving by blocking opioid receptors (μ, κ, and δ) as well as opioid growth factor receptors. Low doses of Naltrexone are used to relieve chronic pain, treat inflammatory diseases and inhibit tumor growth, while high doses or continuous administration exert pro-inflammatory or pro-proliferative effects. Naltrexone relieves intractable pruritus caused by psoriasis, atopic dermatitis and other conditions, and its combination with Bupropion (HY-B0403) inhibits food craving, thereby reducing body weight[1][2][3][4][5]. . Uses: Scientific research. Category: Signaling pathways. CAS No. 16590-41-3. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-76711. | |
| Naltriben mesylate | Naltriben mesylate is a potent δ2-opioid receptor antagonist and a TRPM7 activator. Naltriben mesylate shows Ki values of 0.013 nM, 19 nM and 152 nM for δ, μ and κ receptors, respectively. Naltriben mesylate enhances glioblastoma cell migration and invasion. Naltriben mesylate can be used in research into neurological diseases and cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 122517-78-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg. Product ID: HY-101302. | |
| Namilumab | Namilumab (AMG203) is a human IgG1 monoclonal antibody that binds with high affinity to the GM-CSF ligand, potently neutralizing GM-CSF. Namilumab can be used for the research of rheumatoid arthritis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMG-203; Anti-Human CSF2 Recombinant Antibody. CAS No. 1206681-39-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99307. | |
| N-(Amino-PEG2)-N-bis(PEG3-azide) | N-(Amino-PEG2)-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Amino-PEG2)-N-bis(PEG3-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2606952-86-5. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-140087. | |
| Namitecan | Namitecan is a potent topoisomerase I inhibitor, with antitumor property. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ST-1968. CAS No. 372105-27-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14821. | |
| Namodenoson | Namodenoson (CF-102) is a selective A3 adenosine receptor (A3AR) agonist (Ki=0.33 nM). Namodenoson displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CF-102; 2-Cl-IB-MECA. CAS No. 163042-96-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12365. | |
| Nampt activator-3 | NAMPT activator-3, a NAT derivative, is a NAMPT activator with an EC50 of 2.6 μM and a KD of 132 nM. NAMPT activator-3 effectively protects cultured cells from FK866 (HY-50876)-mediated toxicity. NAMPT activator-3 exhibits strong neuroprotective efficacy in a chemotherapy-induced peripheral neuropathy (CIPN) mouse model without any overt toxicity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2790481-63-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148948. | |
| Nampt degrader-2 | Nampt degrader-2 is a fluorescent PROTAC, which efficiently degrades NAMPT with an IC50 of 41.9 nM. Nampt degrader-2 binds to NAMPT and VHL to form a ternary complex and subsequently induced NAMPT degradation via ubiquitin-proteasome system (UPS). Nampt degrader-2 leads to significant reduction of NAD+ and exerts potent antitumor activities[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3035008-40-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-152154. | |
| Nampt-IN-10 TFA | Nampt-IN-10 TFA (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 TFA shows cellular potency to A2780 and CORL23 cells lines with IC50s of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a novel non-antimitotic payload for ADCs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2567724-20-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147193. | |
| Nampt-IN-15 | Nampt-IN-15 (Example 3) is an Nampt inhibitor. Nampt-IN-15 shows cytotoxicity against BxPC-3, HepG2, L540cy and MOLM-13, with IC50s of 38.5 nM, 8 nM, 8.5 nM, 7 nM respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2222981-61-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-402237. | |
| Nanaomycin A | Nanaomycin A is the first selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells[1]. Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 52934-83-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103397. | |
| Nanatinostat | Nanatinostat (CHR-3996) is a potent, class I selective and orally active HDAC inhibitor with IC50s of 3 nM, 4 nM, and 7 nM for HDAC1, HDAC2, and HDAC3, respectively. Nanatinostat has low activity against HDAC5 (IC50 of 200 nM) and HDAC6 (IC50 of 2100 nM). Nanatinostat induces apoptosis in myeloma cells. Nanatinostat has potent anticancer effects, such as myeloma, advanced solid tumours and colorectal cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CHR-3996. CAS No. 1256448-47-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13432. | |
| Nanchangmycin | Nanchangmycin, a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria[1]. Nanchangmycin is a broad spectrum antiviral active against Zika virus[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Nanchangmycin A. CAS No. 65101-87-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100528. | |
| Nangibotide | Nangibotide (LR12) is a synthetic peptide and TREM-1 receptor inhibitor. Nangibotide inhibits NF-κB and NLRP3 inflammasome activation and reduces the release of pro-inflammatory factors (such as IL-1β, IL-8). Nangibotide inhibits Apoptosis. Nangibotide reduces excessive inflammatory responses and protects tissues (liver, lung) from damage. Nangibotide can be used in the researches for myocardial ischemia-reperfusion injury, septic shock, acute lung injury, osteoarthritis, and acute liver failure[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LR12. CAS No. 2014384-91-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3211. | |
| Napabucasin | Napabucasin (BBI608) is a STAT3 inhibitor which blocks stem cell activity in cancer cells. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BBI608. CAS No. 83280-65-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-13919. | |
| Napamezole hydrochloride | Napamezole hydrochloride is an orally active α-2 adrenergic receptor antagonist and serotonin (5-HT Receptor) reuptake inhibitor, with Ki values of 28 nM and 93 nM for rat α-2 and α-1 adrenergic receptors, respectively. Napamezole hydrochloride can be used for the research of depression[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 87495-33-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W982195. | |
| Naperiglipron | Naperiglipron (LY3549492) is an orally active Glucagon-like peptide 1 receptor (GLP-1R) agonist with an EC50 of 1.14 nM for hGLP-1R. Naperiglipron significantly decreases the level of blood glucose in GLP-1R knock-in mouse models. Naperiglipron inhibits PDE10A1 enzyme activity (IC50: 7.43 μM) with a weak hERG inhibitory activity. Naperiglipron can be used for type II diabetes mellitus (T2DM) and obesity research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY3549492. CAS No. 2572566-11-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-177295. | |
| Naphthalene-2,3-dicarboxaldehyde | Naphthalene-2,3-dicarboxaldehyde (NDA) is an effective inhibitor of Candida albicans aspartate semialdehyde dehydrogenase (ASADH), with a Ki value of 45 μM. Naphthalene-2,3-dicarboxaldehyde targets ASADH in the aspartate biosynthetic pathway of Candida albicans. Naphthalene-2,3-dicarboxaldehyde reacts with primary amines to generate highly fluorescent and stable derivatives. Naphthalene-2,3-dicarboxaldehyde serves as a fungistatic agent and a fluorogenic derivatization reagent. Naphthalene-2,3-Dicarboxaldehyde can be used for the research of candidiasis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2,3-Naphthalenedicarboxaldehyde; Naphthalene-2,3-dialdehyde. CAS No. 7149-49-7. Pack Sizes: 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W016288. | |
| Naphthazarin | Naphthazarin (DHNQ) is a microtubule depolymerizing agent. Naphthazarin can improve motor function and reduce neuroinflammation in mouse models of Parkinson's disease. Naphthazarin can induce tumor cell apoptosis, autophagy, and cell cycle arrest. Naphthazarin can also induce erythrocyte apoptosis. Naphthazarin can be used in the research of tumors and neurodegenerative diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DHNQ; 5,8-Dihydroxy-1,4-naphthoquinone. CAS No. 475-38-7. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg. Product ID: HY-N7526. | |
| Naphthol AS-MX phosphate | Naphthol AS-MX phosphate (NASTRp) is a small molecule inhibitor of the CREB (cyclic adenosine phosphate reaction element binding protein)-CBP (CREB binding protein) transcription factor complex. Naphthol AS-MX phosphate shows antitumor activity against lung cancer cells, inhibiting tumor cell proliferation (IC50=3.701 μmol/L), colony formation, and anchored independent growth in soft AGAR. Naphthol AS-MX phosphate can be used in the study of KRAS mutated lung cancer, especially for KRAS mutated lung cancer with poor chemotherapy resistance and prognosis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NASTRp. CAS No. 1596-56-1. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-104067. | |
| NaPi2b-IN-2 | NaPi2b-IN-2 is a potent inhibitor of sodium-dependent phosphate transporter 2b (SLC34A2, NaPi2b), with an IC50 value of 38 nM against human NaPi2b. NaPi2b-IN-2 reduces intracellular phosphate levels and enhances innate immune gene expression. NaPi2b-IN-2 can be used in research related to hyperphosphatemia[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2227445-31-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-145894. | |
| Naporafenib | Naporafenib (LXH254) is a potent, selective, orally active, type II BRAF and CRAF inhibitor, with IC50 values of 0.072 and 0.21 nM against CRAF and BRAF, respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LXH254. CAS No. 1800398-38-2. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112089. | |
| NAPQI | NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Acetyl-4-benzoquinone Imine. CAS No. 50700-49-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-W017464. | |
| Naproxen | Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (S)-Naproxen. CAS No. 22204-53-1. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g; 10 g; 25 g. Product ID: HY-15030. | |
| Naproxen sodium | Naproxen sodium is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. Uses: Scientific research. Category: Signaling pathways. CAS No. 26159-34-2. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g; 10 g; 25 g. Product ID: HY-15030A. | |
| Naproxen (Standard) | Naproxen (Standard) is the analytical standard of Naproxen. This product is intended for research and analytical applications. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (S)-Naproxen (Standard). CAS No. 22204-53-1. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-15030R. | |
| Naquotinib | Naquotinib (ASP8273) is an orally available, mutant-selective and irreversible EGFR inhibitor; with IC50s of 8-33 nM toward EGFR mutants and 230 nM for EGFR. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ASP8273. CAS No. 1448232-80-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19729. | |
| N-Arachidonylglycine | N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NA-Gly. CAS No. 179113-91-8. Pack Sizes: 5 mg (138.30 mM * 100 μL in Ethanol); 10 mg (138.30 mM * 200 μL in Ethanol); 25 mg (138.30 mM * 500 μL in Ethanol); 50 mg (138.30 mM * 1 mL in Ethanol); 100 mg (138.30 mM * 2 mL in Ethanol). Product ID: HY-103332. | |
| Naratriptan hydrochloride | Naratriptan (GR-85548A) hydrochloride is a selective 5-HT1B/1D receptor agonist. Naratriptan hydrochloride is peripherally active and has good oral bioavailability, inducing cranial artery vasoconstriction by activating 5-HT1B/1D receptors (EC50=0.11 μM for dog basilar artery). Naratriptan hydrochloride also inhibits trigeminal nerve-mediated dural neurogenic plasma extravasation and reduces sterile inflammation. Naratriptan hydrochloride is mainly used in the research of acute migraine, targeting cranial vascular and neuroinflammatory mechanisms[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GR-85548A hydrochloride. CAS No. 143388-64-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-B0197A. | |
| Naratuximab | Naratuximab (Anti-TSPAN26/CD37 Reference Antibody (naratuximab)) is a humanized monoclonal antibody that binds CD37 (TSPAN26). Naratuximab can be used to synthesize an ADC compound, Naratuximab emtansine[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Anti-TSPAN26/CD37 Reference Antibody (naratuximab). CAS No. 1622327-39-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99374. | |
| Naratuximab emtansine | Naratuximab emtansine (IMGN529) is a CD37-targeted ADC consisting of a humanized IgG1 mAb coupled to the microtubule disruptor DM1. Naratuximab emtansine has high affinity and specificity for CD37, allowing ADC internalization, processing and intracellular release of DM1. Due to its ability to disrupt microtubule assembly, DM1 can subsequently induce cell cycle arrest and apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IMGN529; Debio 1562. CAS No. 1607824-64-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-132260. | |
| Narazaciclib | Narazaciclib (ON123300), a strong and brain-penetrant[1] multi-kinase inhibitor, inhibits CDK4 (IC50=3.9 nM), Ark5 (IC50=5 nM), PDGFRβ (IC50=26 nM), FGFR1 (IC50=26 nM), RET (IC50=9.2 nM), and FYN (IC50=11 nM). Single agent Narazaciclib causes a dose-dependent suppression of phosphorylation of Akt as well as activation of Erk in brain tumors[2]. Narazaciclib inhibits CDK6 with an IC50 of 9.82 nM[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ON123300. CAS No. 1357470-29-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12624. | |
| Narciclasine | Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Lycoricidinol. CAS No. 29477-83-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-16563. | |
| Narcissin | Narcissin (Narcissoside), a flavonol glycoside, exhibits evident scavenging activity against both authentic ONOO- and SIN-1-derived ONOO- with IC50s?of 3.5 and 9.6 μM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Narcissoside. CAS No. 604-80-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 20 mg. Product ID: HY-N0649. | |
| Naringenin | Naringenin is the predominant flavanone in Citrus reticulata Blanco; displays strong anti-inflammatory and antioxidant activities. Naringenin has anti-dengue virus (DENV) activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 480-41-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-N0100. | |
| Naringenin chalcone | Naringenin chalcone is an orally active intermediate in flavonol biosynthesis. Naringenin chalcone induces Apoptosis. Naringenin chalcone inhibits the production of MCP-1 and NO. Naringenin chalcone exhibits anticancer activity against glioblastoma. Naringenin chalcone has anti-inflammatory and anti-allergic properties[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 73692-50-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N3007. | |
| Naringenin-d4 | Naringenin-d4 is the deuterated version of Naringenin (HY-N0100). Naringenin shows strong anti-inflammatory and antioxidant activities. Naringenin has anti-dengue virus (DENV) activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1192260-78-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N0100S. | |
| Naringin | Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin also inhibits proliferation and invasion and induces apoptosis in human osteosarcoma cells by inhibiting zinc finger E-box binding homeobox 1 (Zeb1)[1][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Naringoside. CAS No. 10236-47-2. Pack Sizes: 10 mM * 1 mL in DMSO; 200 mg; 10 g. Product ID: HY-N0153. | |
| Naringinase | Naringinase, a hydrolytic enzymatic complex, possesses the activity of both α-L-rhamnosidase and β-D-glucosidase. Naringinase has wide occurrence in nature. Naringinase can be used in the biotransformation of steroids, antibiotics, and mainly on glycosides hydrolysis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9068-31-9. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-129217. | |
| Narirutin | Narirutin, one of the active constituents isolated from citrus fruits, has antioxidant and anti-inflammatory activities. Narirutin is a shikimate kinase inhibitor with anti-tubercular potency[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 14259-46-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N0804. | |
| Narlaprevir | Narlaprevir (SCH 900518) is a selective and orally bioavailable NS3 protease inhibitor with a Ki value of 6 nM and an EC90 value of 40 nM[1]. Narlaprevir also inhibits the HCV nonstructural protein 3 serine protease[2]. Narlaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 2.3 μM[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SCH 900518. CAS No. 865466-24-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10300. | |
| Narlumosbart | Narlumosbart (JMT103) is an IgG4κ antibody targeting receptor activator of nuclear factor-κB ligand (RANKL)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2646587-68-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99966. | |
| Narmafotinib | Narmafotinib (AMP-945) is an orally active inhibitor of the enzyme focal adhesion kinase (FAK, KD=0.21 nM). Narmafotinib inhibits autophosphorylation of 397Y-FAK in MDA-MB-231 cells with an IC50=7 nM and exhibits low general cellular toxicity (IC50=2.7 μM, MDA-MB-231 cells). Narmafotinib can be used for anti-cancer study[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMP-945. CAS No. 1393653-34-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145652. | |
| Narsoplimab | Narsoplimab (OMS 721) is a high-affinity fully human immunoglobulin gamma 4 (IgG4) monoclonal antibody that binds MASP-2 and blocks lectin pathway activation. Narsoplimab can be used in research of hematopoietic stem-cell transplantation and SARS-CoV-2[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OMS 721; Anti-MASP2 Reference Antibody (narsoplimab). CAS No. 2108782-45-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99376. | |
| NAS-181 dimesylate | NAS181 is a potent and selective antagonist of rat 5-HT1B receptor, with a Ki of 47 nM. NAS181 shows 13-fold selectivity for r5-HT1B over bovine 5-HT1B receptor (Ki=630 nM). NAS181 increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT1B autoreceptors[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1217474-40-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103156. | |
| Naspm | Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1-Naphthylacetyl spermine. CAS No. 122306-11-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12506. | |
| Naspm trihydrochloride | Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1-Naphthylacetyl spermine trihydrochloride. CAS No. 1049731-36-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12506A. | |
| NAT | NAT is an initial hit of NAMPT activator with an EC50 of 5.7 μM and a KD of 379 nM. NAMPT is the rate-limiting enzyme in the NAD salvage pathway, which makes it an attractive target for the research of many diseases associated with NAD exhaustion such as neurodegenerative diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 831243-31-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144776. | |
| Natalizumab | Natalizumab (AN100226; BG00002) is a humanized monoclonal IgG4 antibody inhibitor that selectively targets α4 integrin (CD49d). It blocks the interaction of integrins such as α4β1 (VLA-4) with vascular cell adhesion molecule VCAM-1, intercellular adhesion molecule ICAM-1, and fibronectin by competitively binding to the α4 subunit. Natalizumab inhibits the adhesion, retention, and transendothelial migration of immune cells (such as CD4+ T cells), reducing the infiltration of inflammatory cells into the central nervous system or lesion sites, thus exerting anti-inflammatory and immunomodulatory activity. Natalizumab is used in the study of relapsing-remitting multiple sclerosis (RRMS) and also has applications in the study of autoimmune or inflammation-related diseases such as Crohn's disease, B-cell lymphoma, and non-infectious uveitis. Natalizumab can also prevent lymphocytes from entering the central nervous system, thereby preventing acute demyelinating relapses[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 189261-10-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-108831. | |
| Natalizumab (Anti-CD49d) | Natalizumab (Anti-CD49d) (AN100226; BG00002) Solution is a humanized monoclonal IgG4 antibody inhibitor that selectively targets α4 integrin (CD49d), blocking the interaction of integrins such as α4β1 (VLA-4) with vascular cell adhesion molecule VCAM-1, intercellular adhesion molecule ICAM-1, and fibronectin by competitively binding to the α4 subunit. Natalizumab solution inhibits the adhesion, retention, and transendothelial migration of immune cells (such as CD4+ T cells), reducing the infiltration of inflammatory cells into the central nervous system or lesion sites, thereby exerting anti-inflammatory and immunomodulatory activity. Natalizumab (Anti-CD49d) solution is used in the study of relapsing-remitting multiple sclerosis (RRMS) and is also applied in the research of autoimmune or inflammation-related diseases such as Crohn's disease, B-cell lymphoma, and non-infectious uveitis. Natalizumab (Anti-CD49d) can also prevent lymphocytes from entering the central nervous system, thus preventing acute demyelinating relapses[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AN100226; BG00002. CAS No. 189261-10-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108831A. | |
| Natamycin | Natamycin (Pimaricin) is a macrolide antibiotic agent produced by several Streptomyces strains. Natamycin inhibits the growth of fungi via inhibition of amino acid and glucose transport across the plasma membrane. Natamycin is a food preservative, an antifungal agent in agriculture, and is widely used for fungal keratitis research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pimaricin. CAS No. 7681-93-8. Pack Sizes: 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-B0133. | |
| Nateglinide | Nateglinide, a D-phenylalanine derivative, is an orally active and short-acting insulinotropic agent and a DPP IV inhibitor. Nateglinide inhibits ATP-sensitive K+ channels in pancreatic β-cells. Nateglinide is used for the treatment of type 2 (non-insulin-dependent) diabetes mellitus[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: A4166; Senaglinide. CAS No. 105816-04-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0422. | |
| Nauclefine | Nauclefine is an indole alkaloid isolated from Nauclea officinalis. Nauclefine acts as a PDE3A modulator to induce cancer cell apoptosis through a PDE3A-SLFN12-dependent death pathway[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 57103-51-2. Pack Sizes: 1 mg. Product ID: HY-N10149. | |
| Nav1.1 activator 1 | Nav1.1 activator 1 (compound 4), a highly potent Nav1.1 activator with BBB penetration, increases decay time constant (tau) of Nav1.1 currents at 0.03 μM along with significant selectivity against Nav1.2, Nav1.5, and Nav1.6[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2332897-85-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126429. | |
| Nav1.7-IN-19 | Nav1.7-IN-19 is a potent, selective and orally active Nav1.7 inhibitor with an IC50 of 0.49 μM. Nav1.7-IN-19 shows high selectivity for Nav1.7, with selectivities of 312-fold and 662-fold against Nav1.1 and Nav1.5 in the inactivated state. Nav1.7-IN-19 exhibits weak inhibition on hERG potassium channels. Nav1.7-IN-19 exhibits analgesic effect and can be used for the research of neurological disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3097995-73-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-178494. | |
| Nav1.7-IN-3 | Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1788872-06-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101789. | |
| Nav1.7 inhibitor | Nav1.7 inhibitor (compound II), a sulfonamide, is a potent Nav1.7 inhibitor. Nav1.7 inhibitor has the potential for a wide range of disorders, particularly pain, including acute pain, inflammatory pain and/or neuropathic pain[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1355631-24-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13985. | |
| NaV1.7 inhibitor-1 | NaV1.7 inhibitor-1 is an efficacious voltage-gated sodium channel (NaV) 1.7 inhibitor with an IC50 of 0.6 nM for hNaV1.7, exhibits 80-fold selectivity versus hNaV1.5[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1494585-79-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119934. | |
| Navacaprant | Navacaprant (BTRX-335140) is a selective and orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8 nM, 110 nM, and 6500 nM, respectively.Navacaprant endows with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rats. Navacaprant distributes well into the CNS and can be used for the research of neuropathy[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BTRX-335140; CYM-53093. CAS No. 2244614-14-8. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-124754. | |
| Navarixin | Navarixin (SCH 527123) is a potent, allosteric and orally active antagonist of both CXCR1 and CXCR2, with Kd values of 41 nM for cynomolgus CXCR1 and 0.20 nM, 0.20 nM, 0.08 nM for mouse, rat and cynomolgus monkey CXCR2, respectivelly[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SCH 527123; MK-7123. CAS No. 473727-83-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10198. | |
| Navepdekinra | Navepdekinra (DC-806) is an orally active, potent interleukin-17A (IL-17A) inhibitor (IC50 = 10.81 nM). Navepdekinra disrupts the IL-17A protein-receptor interaction, suppressing the downstream pro-inflammatory signaling pathway. Navepdekinra inhibits arthritis in a collage-induced arthritis (CIA) rat model. Navepdekinra can be used for psoriasis, psoriatic arthritis, and ankylosing spondylitis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DC-806; LY4100504; S-011806. CAS No. 2467732-66-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153780. | |
| Navitoclax | Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABT-263. CAS No. 923564-51-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10087. | |
| Navitoclax-piperazine | Navitoclax-piperazine (ABT-263-piperazine) is a Navitoclax (HY-10087) analog and BCL-XL inhibitor. Navitoclax-piperazine is the ligand for target protein of PROTAC DT2216 (HY-130604). Navitodax-pperaie and E3 ubiquitin ligase VHL ligand can be used to synthesize PROTAC DT2216 (HY-130604)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABT-263-piperazine. CAS No. 2143096-93-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-44432. | |
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