MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Nevanimibe | Nevanimibe (PD-132301) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe induces cell apoptosis and has the potential for adrenocortical cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PD-132301; ATR-101. CAS No. 133825-80-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100399. |  |
| Nevanimibe hydrochloride | Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PD-132301 hydrochloride; ATR101 hydrochloride. CAS No. 133825-81-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100399A. | |
| Nevirapine | Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BI-RG 587; NSC 641530; NVP. CAS No. 129618-40-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10570. | |
| Nevirapine-d3 | Nevirapine-d3 (BI-RG 587-d3) is the deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1051419-24-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-10570S1. | |
| Nevirapine (Standard) | Nevirapine (Standard) is the analytical standard of Nevirapine. This product is intended for research and analytical applications. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BI-RG 587 (Standard); NSC 641530 (Standard); NVP (Standard). CAS No. 129618-40-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10570R. | |
| Nexinhib20 | Nexinhib20 is an inhibitor that targets the interactions of Rab27a-JFC1 (IC50: 2.6 μM) and Rac-1-GTP. Nexinhib20 can inhibit neutrophil exocytosis, adhesion, and β2 integrin activation, and has anti-inflammatory activity. Nexinhib20 can be used in the research of diseases such as systemic inflammation and myocardial ischemia-reperfusion injury[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 331949-35-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125792. | |
| Nexturastat A | Nexturastat A is a potent, selective HDAC6 inhibitor. Nexturastat A has inhibitory for HDAC6 with an IC50 of 5 nM. Nexturastat A can be used for the research of multiple myeloma (MM)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1403783-31-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16699. | |
| Nezutatug | Nezutatug (HMBD-001) is a humanized IgG1 monoclonal antibody inhibitor targeting HER3. Nezutatug inhibits the dimerization of HER3 and inhibits the growth, proliferation and other activities of tumor cells. Nezutatug is promising for research of cancers, such as pancreatic cancer and non-small cell lung cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HMBD-001. CAS No. 2673271-78-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P991237. | |
| NF023 hexasodium | NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 104869-31-0. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg. Product ID: HY-108676. | |
| NF157 | NF157 is a highly selective nanomolar P2Y11 antagonist with a pKi of 7.35. The IC50s are 463 nM, 1811 μM, 170 μM for P2Y11 (Ki=44.3 nM), P2Y1 (Ki=187 μM), P2Y2 (Ki=28.9 μM), respectively[1]. NF157, significantly reduces expression of metalloproteinase (MMP)-3, MMP-13, can be used in the treatment of osteoarthritis (OA)[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 104869-26-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-108672. | |
| NF279 | NF279 is a selective P2X1 receptor antagonist and NTPDase inhibitor, with a P2X1 IC50 value of 19 nM. NF279 suppresses GABA-evoked currents, reduces ATP-excited respiratory activity, alters hypoglossal nerve burst parameters, and blocks CXCR4, CCR5, CXCR3, and CXCR7-mediated calcium responses. NF279 arrests HIV-1 fusion downstream of CD4 binding, inhibits R5- and X4-tropic HIV-1 strains. NF279 can be used for the research of HIV-1 infection[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 202983-32-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-D0976. | |
| NF449 octasodium | NF449 octasodium is a highly potent P2X1 receptor antagonist, with IC50s of 0.28, 0.69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively. NF449 octasodium is a Gsα-selective G Protein antagonist. NF449 octasodium suppresses the rate of GTP[γS] binding to Gsα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks the coupling of β-adrenergic receptors to Gs[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 627034-85-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112461A. | |
| NF-56-EJ40 | NF-56-EJ40 is a potent, high-affinity, and highly selective human SUCNR1 (GPR91) antagonist with an IC50 of 25 nM and a Ki of 33 nM, and shows almost no activity towards rat SUCNR1. NF-56-EJ40 has high affinity for humanized rat SUCNR1 with a Ki value of 17.4 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2380230-73-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130246. | |
| NF764 | NF764 is a potent β-catenin (CTNNB1) degrader. NF764 reduces CTNNB1 protein levels in a proteasome-dependent manner. NF764 can be used in the study of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3083634-54-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-161719. | |
| NFAT Inhibitor-1 | NFAT Inhibitor (VIVIT peptide) is an inhibitor of nuclear factor of activated Tcells (NFAT) that selectively inhibits calcineurin-mediated dephosphorylation of NFAT[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VIVIT peptide. CAS No. 249537-73-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P1026. | |
| NF-κΒ activator 1 | NF-κΒ activator 1 (compound 32) is a potent NF-κΒ activator with an EC50 of 0.9 μM. NF-κΒ activator 1 induces superoxide dismutase (SOD)2 mRNA expression[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2387524-59-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134476. | |
| NF-κB-IN-11 | NF-κB-IN-11 (Compound 3i) is a NF-κB inhibitor. NF-κB-IN-11 inhibits TNF-α induced activation of NF-κB pathway, and inhibits nuclear translocation of NF-κB. NF-κB-IN-11 down-regulates the expression levels of phosphor-IKK, IκBα, and NF-κB p65. NF-κB-IN-11 has anti-inflammatory activity, and alleviates dextran sulfate sodium-induced colitis in mice. NF-κB-IN-11 (p.o.) shows a MTD more than 1852 mg/kg in mice acute toxicity assay[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2768833-35-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155998. | |
| NF-κB-IN-4 | NF-κB-IN-4 (compound 17) is a potent NF-κB pathway inhibitor with blood brain barrier (BBB) permeability. NF-κB-IN-4 exhibits potential anti-neuroinflammatory activity with low toxicity. NF-κB-IN-4 can block the activation and phosphorylation of IκBα, reduce expression of NLRP3, and thus inhibit NF-κB activation. NF-κB-IN-4 can be used for neuroinflammation related diseases research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3033258-60-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144765. | |
| N-Fmoc-5,5,5-trifluoro-L-norvaline | N-Fmoc-5,5,5-trifluoro-L-norvaline is an amino acid derivative that can be used for compound synthesis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 144207-41-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 1 g. Product ID: HY-W074914. | |
| N-Fmoc-L-valine N-succinimidyl ester | N-Fmoc-L-valine N-succinimidyl ester is a valine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 130878-68-1. Pack Sizes: 25 g; 50 g; 100 g. Product ID: HY-78733. | |
| N-Fmoc-N,O-dimethyl-L-serine | N-Fmoc-N,O-dimethyl-L-serine is a serine derivative that can be used for coibamide A synthesis. Coibamide A is a marine natural product with potent antiproliferative activity against human cancer cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1569103-64-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 1 g; 5 g. Product ID: HY-W039102. | |
| N-Formylcytisine | N-Formylcytisine is a cytisine-type alkaloid from the stem bark of Maackia amurensis[1]. Uses: Scientific research. Category: Natural products. CAS No. 53007-06-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N7625. | |
| N-Formylkynurenine | N-Formylkynurenine is an intermediate in the catabolism of tryptophan. It is a formylated derivative of kynurenine. The formation of N-formylkynurenine is catalyzed by heme dioxygenases. Uses: Scientific research. Category: Signaling pathways. CAS No. 1022-31-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-28247. | |
| N-Formyl-Met-Leu-Phe | N-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR). N-Formyl-Met-Leu-Ph is reported to inhibit TNF-alpha secretion. Uses: Scientific research. Category: Signaling pathways. Alternative Names: fMLP; N-Formyl-MLF. CAS No. 59880-97-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0224. | |
| N-Formyl-Met-Leu-Phe-Lys | N-Formyl-Met-Leu-Phe-Lys (fMLFK) is a peptide, acts as a potent and selective agonist of FPR1, with EC50s of 3.5 nM, 6.7 μM and 0.88 μM for FPR1, FPR2 and FPR2-D2817.32G, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: fMLFK. CAS No. 67247-11-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1744. | |
| N-Formyl-MMYALF | N-Formyl-MMYALF is a potent mitochondrial N-formyl peptide (mtFP) that has the activity of depleting calcium ions in the endoplasmic reticulum. N-Formyl-MMYALF can inhibit the FPR-1-mediated chemotactic response of polymorphonuclear leukocytes (PMNs) to bacterial peptides[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 863418-59-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10738. | |
| NG25 | NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1315355-93-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-15434. | |
| NG-497 | NG-497 is a selective human adipose triglyceride lipase (ATGL) inhibitor that targets the enzymatically active patatin-like domain of human ATGL. NG-497 has potential value for tumor research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2598242-66-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148756. | |
| NG 52 | NG 52 is a potent, cell-permeable, selective, ATP-compatible and orally active Cdc28p and Pho85p kinase inhibitor with IC50s of 7 μM and 2 μM, respectively. NG 52 also inhibits the activity of phosphoglycerate kinase 1 (PGK1) with an IC50 of 2.5 μM. NG 52 is inactive against yeast kinases Kin28p, Srb10, and Cak1p[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Compound 52. CAS No. 212779-48-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15154. | |
| NGI-1 | NGI-1 (ML414) is a potent oligosaccharyltransferase (OST) inhibitor, directly targeting and blocking the function of the OST catalytic subunits STT3A and STT3B[1]. NGI-1 is a cell permeable inhibitor and can effectively reduce virus infectivity without affecting cell viability[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ML414. CAS No. 790702-57-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-117383. | |
| NGI-235 | NGI-235 is an STT3A-selective oligosaccharyltransferase complex OST-A inhibitor. NGI-235 preferentially inhibits OST-A catalytic activity, impairing N-glycosylation of OST-A substrates. NGI-235 causes the hypoglycosylation of both TLR4, GLUT1 and inhibits NF-κB signaling. NGI-235 can be used for the research of inflammation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2763063-40-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-175674. | |
| N-Glycolylneuraminic acid | N-Glycolylneuraminic acid is a nonhuman sialic acid molecule synthesized in pigs but not in humans. N-Glycolylneuraminic acid works as a decoy receptor of N-Glycolylneuraminic acid-binding influenza A viruses (IAVs)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NeuGc; GcNeu. CAS No. 1113-83-3. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128965. | |
| NG-nitro-L-arginine | NG-nitro-L-arginine (Nω-nitro-L-arginine) is a NO Synthase inhibitor, with Kis of 0.61 μM (nNOS), 4.28 μM (iNOS), 0.72 μM (eNOS) respectively. NG-nitro-L-arginine inhibits endothelium-derived relaxing factor (EDRF) formation and release. NG-nitro-L-arginine inhibits portal-systemic shunting in portal-hypertensive rats, and increases blood pressure[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Nω-nitro-L-arginine; L-NOARG; L-NG-Nitroarginine. CAS No. 2149-70-4. Pack Sizes: 25 g; 50 g; 100 g. Product ID: HY-12115. | |
| NH125 | NH125 is a potent and selective inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K/CaMKIII) with an IC50 of 60 nM for eEF-2K. NH125 kills methicillin-resistant S. aureus (MRSA) persisters by interacting with and disrupting membranes[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 278603-08-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100576. | |
| NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT | NH2-bicyclopentane-7-MAD-MDCPT (Formula I) is a topoisomerase I (TOP1) inhibitor. NH2-bicyclopentane-7-MAD-MDCPT is applicable to the synthesis of the ADC ABBV-969. NH2-bicyclopentane-7-MAD-MDCPT is used in research on lung adenocarcinoma and melanoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2857037-69-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-148819. | |
| NH2-C2-NH-Boc | NH2-C2-NH-Boc (PROTAC Linker 22) is a alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PROTAC Linker 22. CAS No. 57260-73-8. Pack Sizes: 50 g; 100 g; 250 g; 500 g; 1 k g. Product ID: HY-40171. | |
| NH2-C4-NH-Boc | NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 68076-36-8. Pack Sizes: 10 g. Product ID: HY-40178. | |
| NH2-C5-NH-Boc | NH2-C5-NH-Boc (PROTAC Linker 23) is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PROTAC Linker 23. CAS No. 51644-96-3. Pack Sizes: 1 g; 5 g; 10 g. Product ID: HY-W004710. | |
| NH2-C6-NH-Boc | NH2-C6-NH-Boc is a PROTAC linker which refers to the alkyl/ether composition. NH2-C6-NH-Boc can be used in the synthesis the Mcl-1 inhibitor based on PROTAC[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 51857-17-1. Pack Sizes: 1 g; 5 g; 10 g; 25 g; 100 g; 500 g. Product ID: HY-W008296. | |
| NH2 DOTA-GA | NH2 DOTA-GA is a DOTA-based metal chelator that can be used to prepare radionuclide drug conjugates (RDCs) whose carboxylic acid groups can complex metal ions, for example, NH2 DOTA-GA complexes Gd(III) ions. Uses: Scientific research. Category: Signaling pathways. CAS No. 1639843-65-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164569. | |
| NH2-PEG2000-COOH | NH2-PEG2000-COOH is a heterofunctional polyethylene glycol with one amino terminal group and one carboxyl terminal group. NH2-PEG2000-COOH reacts with N-succinimidyl-6-maleimidohexanoate to introduce a maleimide terminal group, followed by conjugation with thiolated RGD peptide via a thiol-maleimide coupling reaction to synthesize RGD-PEG-COOH. NH2-PEG2000-COOH can be used in cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 139729-28-5. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-168940B. | |
| NH2-PEG2000-NH2 | NH2-PEG2000-NH2 is a polyethylene glycol derivative containing two primary amine groups. The amino group can react quickly with activated carboxylic acid or carboxyl groups such as NHS esters to form stable amide bonds. The PEGylation of NH2-PEG-NH2 can increase solubility and stability, and reduce the immunogenicity of peptides and proteins, so it is mostly used to modify proteins, peptides and other substances. Uses: Scientific research. Category: Signaling pathways. CAS No. 956496-54-1. Pack Sizes: 250 mg; 500 mg; 1 g. Product ID: HY-W451406C. | |
| NH2-PEG3-C1-Boc | NH2-PEG3-C1-Boc (PROTAC Linker 5) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PROTAC Linker 5. CAS No. 189808-70-6. Pack Sizes: 100 mg; 250 mg. Product ID: HY-128801. | |
| NH2-PEG3-C2-NH-Boc | NH2-PEG3-C2-NH-Boc (PROTAC Linker 15) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PROTAC Linker 15. CAS No. 101187-40-0. Pack Sizes: 100 mg; 250 mg. Product ID: HY-42776. | |
| NH2-PEG3-VC-PAB-MMAE | NH2-PEG3-VC-PAB-MMAE is a drug-linker conjugate for ADC, consisting of a cleavable ADC linker (NH2-PEG3-VC-PAB) and a potent tubulin inhibitor Monomethyl auristatin E (MMAE) (HY-15162). NH2-PEG3-VC-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2641442-97-7. Pack Sizes: 5 mg. Product ID: HY-164239. | |
| NH2-PEG4-CH2CH2COOH | NH2-PEG4-CH2CH2COOH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG4-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Uses: Scientific research. Category: Signaling pathways. CAS No. 663921-15-1. Pack Sizes: 100 mg; 500 mg; 1 g. Product ID: HY-W021787. | |
| NH2-PEG4-DOTA | NH2-PEG4-DOTA is a bifunctional DOTA chelator with one carboxyl group modified by NH2-PEG4, possessing both a metal-binding domain and a chemically reactive functional group. NH2-PEG4-DOTA can be used for time-resolved fluorescence assays[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2090232-34-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W755033. | |
| NH2-PEG6-Boc | NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1286281-32-0. Pack Sizes: 100 mg; 250 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-130486. | |
| NH2-PEG6-CH2CH2COOH | NH2-PEG6-CH2CH2COOH is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG6-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 905954-28-1. Pack Sizes: 100 mg; 250 mg; 1 g; 5 g. Product ID: HY-W040257. | |
| NH2-UAMC1110 TFA | NH2-UAMC1110 TFA is an aminobutoxy derivative of the fibroblast activation protein (FAP) inhibitor UAMC1110 (HY-100684), and is a precursor compound for the synthesis of FAP inhibitor probes, not directly used in bioactivity experiments. For example, NH2-UAMC1110 TFA is involved in the synthesis of the radiotracer FAPI-QS, which exhibits high tumor selectivity and high dose effect, and has been used in tumor diagnosis. NH2-UAMC1110 TFA structurally incorporates an active amino group, allowing it to form covalent bonds with various molecules (such as DOTA, DATA5m, radionuclide chelators, etc.) to synthesize molecular imaging probes or targeted compounds with the ability to target FAP. NH2-UAMC1110 TFA specifically binds to the FAP active site, inhibiting its proline-selective serine protease activity (including dipeptidyl peptidase and endopeptidase activity), blocking FAP-mediated tissue remodeling-related processes. Its key activity is high targeting and high affinity, and its core function is to act as a targeting module coupled with bifunctional chelators (such as DOTA, DATA5m). NH2-UAMC1110 TFA can be applied to diagnostic imaging studies of tumors expressing FAP (such as colorectal cancer, pancreatic cancer, etc.), and also provides molecular tools for targeted research of FAP-related diseases with high FAP expression, such as fibrosis and arthritis[1][2]. Uses: Scientific research. Category: Signaling pathways. CASÂ… | |
| NH-3 | NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment[1][2][3]. NH-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 447415-26-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141513. | |
| NHE3-IN-2 | NHE3-IN-2 is a Na+/H+ exchanger-3 (NHE3) inhibitor ( patent WO2001079186A1, example 6-Chlor-4-phenyl-2-chinazolinyl-guanidin)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 92434-13-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139313. | |
| N-Hexanoyl-DL-homoserine lactone | N-Hexanoyl-DL-homoserine lactone is a bacterial quorum sensing molecule produced in the rhizosphere. N-Hexanoyl-DL-homoserine lactone, a bacterial quorum sensing signal, induces transcriptional changes in Arabidopsis and may contribute to tuning plant growth to the microbial composition of the rhizosphere[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 106983-28-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W045071. | |
| N-Hexanoyl-L-homoserine lactone | N-Hexanoyl-L-homoserine lactone is a short-chained N-acyl homoserine lactone (AHL). N-hexanoyl-L-homoserine lactone is also a mediator of bacterial quorum-sensing regulation. N-hexanoyl-L-homoserine lactone promotes lipid accumulation in algae. AHL is an intercellular communication signal molecule in the quorum sensing system of Gram-negative bacteria and a medium for mediating information exchange between eukaryotic plants and prokaryotic bacteria. AHL can affect bacteria activities, such as biofilm formation, pigment synthesis, and antibiotic synthesis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: C6-HSL. CAS No. 147852-83-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133685. | |
| NHS-MMAF | NHS-MMAF is a modified MMAF extracted from patent WO2012143499, intermediat 219. MMAF is a potent tubulin polymerization inhibitor and is used as a antitumor agent[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1404073-19-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-139326. | |
| NHS-PEG-NHS | NHS-PEG-NHS is a derivative of activated polyethylene glycol (PEG) that can modify functional groups on protein surfaces via covalent binding. NHS-PEG-NHS serves as a bioconjugation modification reagent for modifying proteins, enzymes, peptides and antibodies[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 122375-06-8. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W451415. | |
| NHS-SS-biotin | NHS-SS-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 122266-55-1. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-140129. | |
| NHWD-870 | NHWD-870 is a potent, orally active and selective BET family bromodomain inhibitor and only binds bromodomains of BRD2, BRD3, BRD4 (IC50=2.7 nM), and BRDT. NHWD-870 has potent tumor suppressive efficacies and suppresses cancer cell-macrophage interaction. NHWD-870 increases tumor apoptosis and inhibits tumor proliferation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2115742-03-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134463. | |
| N-Hydroxypipecolic acid | N-Hydroxypipecolic acid (1-Hydroxy-2-piperidinecarboxylic acid), a plant metabolite and a systemic acquired resistance (SAR) regulator, orchestrates SAR establishment in concert with the immune signal salicylic acid. N-Hydroxypipecolic acid accumulates systemically in the plant foliage in response to pathogen attack. N-Hydroxypipecolic acid induces SAR to bacterial and oomycete infection[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1-Hydroxy-2-piperidinecarboxylic acid; NHP. CAS No. 115819-92-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-N7378. | |
| N-Hydroxysuccinimide | N-Hydroxysuccinimide (HOSu; 1-Hydroxy-2,5-pyrrolidinedione) is a covalent crosslinker commonly used in bioconjugation technology with a primary amine group. N-Hydroxysuccinimide reacts with amino groups (-NH2) to form a stable amide bond, which can modify amino-containing biomolecules. N-Hydroxysuccinimide can be used, for example, for protein labeling with fluorescent dyes and enzymes, surface activation of chromatography supports, microbeads, nanoparticles and microarray slides, and chemical synthesis of peptides. N-Hydroxysuccinimide has a wide range of applications in biomaterial synthesis (such as collagen, chitosan crosslinking), drug delivery systems (such as hydrogel preparation) and tissue engineering[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HOSu; 1-Hydroxy-2,5-pyrrolidinedione. CAS No. 6066-82-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g; 50 g; 100 g. Product ID: HY-Y0623. | |
| N-Hydroxysulfosuccinimide sodium | N-Hydroxysulfosuccinimide (sodium) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 106627-54-7. Pack Sizes: 500 mg; 1 g; 5 g; 10 g; 25 g; 100 g. Product ID: HY-W002213. | |
| NI-42 | NI-42 (compound 13-d), a structurally orthogonal chemical probe for the BRPFs, is a biased, potent inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM) with excellent selectivity over nonclass IV BRD proteins[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1884640-99-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101121. | |
| NI-57 | NI-57, a chemical probe, is an inhibitor of bromodomain and plant homeodomain finger-containing (BRPF) famlily of proteins, with IC50s of 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1) and BRPF3, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1883548-89-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19537. | |
| Niacin | Niacin (Vitamin B3) is an orally active water-soluble B3 vitamin that is an essential nutrient for humans. Niacin (Vitamin B3) plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin (Vitamin B3) is also used in the study of cardiovascular diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Nicotinic acid; Vitamin B3. CAS No. 59-67-6. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-B0143. | |
| Niacin-d4 | Niacin-d4 is the deuterium labeled Niacin. Niacin (Nicotinic acid) is a vitamin and is part of the vitamin B group. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Nicotinic acid-d4; Vitamin B3-d4. CAS No. 66148-15-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0143S2. | |
| NIAD-4 | NIAD-4 is a blood-brain barrier permeable fluorophore for optical imaging of amyloid-β (Aβ) in the central nervous system (CNS) for Alzheimers disease (AD). NIAD-4 binds to the same Aβ site with the binding affinity (Ki) of 10 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 868592-56-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111263. | |
| NIBR189 | NIBR189 is an EBI2 (Epstein-Barr virus-induced gene 2) antagonist. NIBR189 inhibits human and mouse EBI2 with IC50s of 11 and 16 nM, respectively. NIBR189 can be used for the research of autoimmune diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1599432-08-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12336. | |
| NIC-0102 | NIC-0102 is an orally active proteasome inhibitor (pIC50=7.55) that specifically inhibits NLRP3 inflammatory vesicle activation. NIC-0102 shows potent anti-inflammatory effects in a model of dextran sulfate sodium (DSS)-induced ulcerative colitis. NIC-0102 also inhibits production of pro-IL-1β[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2806031-94-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-151252. | |
| Nicardipine | Nicardipine (YC-93 free base) is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine acts as an agent for chronic stable angina and for controlling blood pressure[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: YC-93 free base. CAS No. 55985-32-5. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg. Product ID: HY-12515. | |
| Nicardipine-d3 hydrochloride | Nicardipine-d3 hydrochloride (YC-93 D3) is the deuterium labeled Nicardipine hydrochloride. Nicardipine hydrochloride is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine hydrochloride acts as an agent for chronic stable angina and for controlling blood pressure[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: YC-93-d3. CAS No. 1432061-50-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-12515AS. | |
Would you like to list your products on USA Chemical Suppliers?
Our database is helping our users find suppliers everyday.