MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| ND-646 | ND-646 is an orally bioavailable and steric inhibitor of acetyl-CoA carboxylase (ACC) with IC50s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1434639-57-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101842. |  |
| N-DBCO-N-bis(PEG2-C2-NHS ester) | N-DBCO-N-bis(PEG2-C2-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-DBCO-N-bis(PEG2-C2-NHS ester) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2128735-29-3. Pack Sizes: 50 mg; 100 mg. Product ID: HY-140585. | |
| N-deacetylated BMS-202 | N-deacetylated BMS-202 is the deacetylated of BMS-202. BMS-202 is an inhibitor of the PD-1/PD-L1 interaction, mainly used for cancer treatment. Uses: Scientific research. Category: Signaling pathways. CAS No. 2310135-18-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19745A. | |
| N-Decanoylglycine | N-Decanoylglycine is a Glycine (HY-Y0966) derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 14305-32-9. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 1 g. Product ID: HY-131173. | |
| N-Desethyl amodiaquine | N-Desethyl amodiaquine is the biologically active metabolite of Amodiaquine (HY-B1322A). N-Desethyl amodiaquine is an antiparasitic agent, has inhibitory for strains V1/S and 3D7 with IC50 values of 97 nM and 25 nM, respectively. N-Desethyl amodiaquine can be used for the research of malaria[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 79352-78-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-128554. | |
| N-Desethyl amodiaquine-d5 | N-Desethyl amodiaquine-d5 is the deuterium labeled N-Desethyl amodiaquine. N-Desethyl amodiaquine is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1173023-19-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-128554S. | |
| N-Desethyl Sunitinib | N-Desethyl Sunitinib (SU-12662) is a metabolite of Sunitinib (HY-10255A). N-Desethyl Sunitinib serves as a good transport substrate for human ABCB1, ABCG2 and murine ABCG2[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SU-12662. CAS No. 356068-97-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10873. | |
| N-Deshydroxyethyl Dasatinib | N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, Dasatinib is a multi-kinase inhibitor that potently inhibits Bcr-Abl, Src family and platelet-derived growth factor receptor kinases. N-Deshydroxyethyl Dasatinib can be used in cancer and immune disease research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Deshydroxyethyl BMS-354825. CAS No. 910297-51-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107447. | |
| N-Desmethyl-Apalutamide | N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1332391-11-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-135331. | |
| N-Desmethyl Bedaquiline-d6 | N-Desmethyl Bedaquiline-d6 is the deuterium labeled N-Desmethyl Bedaquiline[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2271264-26-5. Pack Sizes: 1 mg. Product ID: HY-143922S. | |
| N-Desmethyl clomipramine hydrochloride | N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Desmethylclomipramine hydrochloride; Norclomipramine hydrochloride. CAS No. 29854-14-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12388A. | |
| N-Desmethylclozapine | N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Norclozapine; Desmethylclozapine; Normethylclozapine. CAS No. 6104-71-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-G0021. | |
| N-Desmethyl enzalutamide | N-desmethyl Enzalutamide is the active metabolite of Enzalutamide.N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Desmethyl MDV 3100. CAS No. 1242137-16-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-70002A. | |
| N-Desmethyl enzalutamide-d6 | N-desmethyl Enzalutamide-d6 is a deuterium labeled N-desmethyl Enzalutamide. N-desmethyl Enzalutamide is an active metabolite of Enzalutamide. N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Desmethyl MDV 3100-d6. CAS No. 2748567-63-5. Pack Sizes: 1 mg. Product ID: HY-70002AS. | |
| N-Desmethyl imatinib | N - Desmethyl imatinib (Norimatinib) is an active metabolite of Imatinib (HY-15463), a selective c - Abl inhibitor, and a substrate of P - glycoprotein. N-Desmethyl imatinib binds to the c-Abl catalytic domain to prevent substrate phosphorylation, inhibits c-Abl-mediated α-synuclein activation and downstream inflammatory signaling pathways. N-Desmethyl imatinib induces apoptosis in K562 human leukemia cells. N-Desmethyl imatinib shows significantly elevated plasma levels in gastrointestinal stromal tumor (GIST) models with mild SARS-CoV-2 infection. N-Desmethyl imatinib can be used for the research of Parkinsons disease, gastrointestinal stromal tumor, and chronic myeloid leukemia[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Norimatinib; Imatinib metabolite N-Desmethyl imatinib; CGP 74588. CAS No. 404844-02-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-G0017. | |
| N-Desmethyltamoxifen hydrochloride | N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 15917-65-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129099A. | |
| NDI-091143 | NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay), a Ki of 7.0 nM and a Kd of 2.2 nM. NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2375840-87-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-127111. | |
| N-Di(D-mannose)-PEG12-MC-VC-PAB-MMAE | N-Di(D-mannose)-PEG12-MC-VC-PAB-MMAE is a linker that can be synthesized to antibody-drug conjugate (ADC). N-Di(D-mannose)-PEG12-MC-VC-PAB-MMAE can be used for the study of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2892440-83-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-177577. | |
| N-dodecanoyl-L-Homoserine lactone | N-dodecanoyl-L-Homoserine lactone (C12-HSL) is a quorum sensing (QS) signaling molecule. N-dodecanoyl-L-Homoserine lactone (C12-HSL) aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: C12-HSL. CAS No. 137173-46-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118697. | |
| N-Dodecyl-β-D-maltoside | N-Dodecyl-β-D-maltoside (Lauryl Maltoside) is a non-ionic detergent. N-Dodecyl-β-D-maltoside has strong adsorption on alumina, titanium dioxide and hematite. N-Dodecyl-β-D-maltoside can promote the reactivation of various proteins. N-Dodecyl-β-D-maltoside can effectively stabilize photoactive reaction center complexes (RCs) and inhibit the degradation of Rhodopseudomonas spheroides R-26 reaction center in solution. N-Dodecyl-β-D-maltoside can be used for purification and stabilization of RNA polymerase and for detection of protein-lipid interactions[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Lauryl Maltoside. CAS No. 69227-93-6. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-128974. | |
| N-Dodecyl-β-D-maltoside-d25 | N-Dodecyl-β-D-maltoside-d25 (Lauryl Maltoside-d25) is deuterium labeled N-Dodecyl-β-D-maltoside (HY-128974). N-Dodecyl-β-D-maltoside is a non-ionic detergent. N-Dodecyl-β-D-maltoside has strong adsorption on alumina, titanium dioxide and hematite. N-Dodecyl-β-D-maltoside can promote the reactivation of various proteins. N-Dodecyl-β-D-maltoside can effectively stabilize photoactive reaction center complexes (RCs) and inhibit the degradation of Rhodopseudomonas spheroides R-26 reaction center in solution. N-Dodecyl-β-D-maltoside can be used for purification and stabilization of RNA polymerase and for detection of protein-lipid interactions[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Lauryl Maltoside-d25. CAS No. 849110-74-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-128974S. | |
| NDT-19795 | NDT-19795 is an effective inhibitor of the NLRP3 inflammasome with an IC50 value of 66 nM in the PBMC method and 4.7 μM in the WB method. NDT-19795 is a carboxylic acid-active substance that can be converted from NT-0796 (HY-156438) within cells. NDT-19795 can be used for the studies of inflammation and neurological diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2272917-12-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158024. | |
| NDT 9513727 | NDT 9513727 is a potent, selective, orally active and competitive inverse agonist of the human C5aR (C5a receptor), with an IC50 of 11.6 nM. NDT 9513727 can be used for the research of human inflammatory diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 439571-48-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110060. | |
| NE-100 hydrochloride | NE-100 hydrochloride is an orally active and selective sigma-1 receptor antagonist with an IC50 of 4.16 nM. NE-100 hydrochloride can improve cognitive impairment and has neuroprotective and antipsychotic activities. NE-100 hydrochloride can be used for research on nervous system diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 149409-57-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-101484A. | |
| NE 10790 | NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3-PEHPC. CAS No. 152831-36-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16011. | |
| NE 52-QQ57 | NE 52-QQ57 is a selective, and orally available GPR4 antagonist with an IC50 of 70 nM. NE 52-QQ57 has anti-inflammatory activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1401728-56-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101784. | |
| Nebivolol | Nebivolol (R 065824) is an orally active beta receptor blocker and has the high beta(1)-receptor affinity. Nebivolol has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R 065824. CAS No. 118457-14-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-B0203. | |
| Nebivolol hydrochloride | Nebivolol (R 065824) hydrochloride is an orally active beta receptor blocker and has the high beta(1)-receptor affinity.Nebivolol hydrochloride has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol hydrochloride can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R 065824 hydrochloride. CAS No. 152520-56-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B0203A. | |
| Neboglamine hydrochloride | Neboglamine (CR-2249, XY-2401) hydrochloride is an orally active NMDA receptor glycine site positive modulator that can be used in schizophrenia research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CR-2249 hydrochloride; XY-2401 hydrochloride. CAS No. 2759182-59-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114753A. | |
| Nebokitug | HY-P991010 is an CCL24-targeting IgG1κ type human antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CM101. CAS No. 2922315-59-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P991010. | |
| Nebratamig | Nebratamig (GNC-035) is an anti-ROR1/anti-CD3/anti-PD-L1/anti-4-1BB tetra-specific antibody with potential immunostimulatory and antineoplastic activities[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GNC-035. CAS No. 2694723-68-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P991209. | |
| Necitumumab | Necitumumab (11F8; IMC-11F8; LY3012211) is a human IgG monoclonal antibody directed against EGFR. Necitumumab binds to the EGF binding site of EGFR, blocks ligand binding, neutralizes ligand-induced EGFR phosphorylation and downstream signaling, induces EGFR internalization and degradation, and mediates antibody-dependent cellular cytotoxicity (ADCC) in EGFR-expressing cells. Necitumumab enhances antitumour activity in combination with Gemcitabine (HY-17026) and Cisplatin (HY-17394) in murine non-small-cell lung cancer xenograft models. Necitumumab can be used in research on cancers such as non-small cell lung cancer and colorectal cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 11F8; IMC-11F8; LY3012211. CAS No. 906805-06-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9964. | |
| Necrocide 1 | Necrocide 1, a necrosis by sodium overload (NECSO) inducer, is a selective transient receptor potential melastatin 4 (TRPM4) agonist with an EC50 of 306.3 nM for human TRPM4. Necrocide 1 triggers TRPM4-dependent necrotic cell death through the induction of sodium influx. Necrocide 1 induces hallmarks of immunogenic cell death incurring calreticulin (CALR) exposure, ATP secretion and high mobility group box 1 (HMGB1) release. Necrocide 1 can be used for the study of breast and prostate cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1247028-61-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14307. | |
| Necrosis inhibitor 2 | Necrosis inhibitor 2 (Compound B19) is a cell necrosis inhibitor. Necrosis inhibitor 2 can be used to study diseases related to the necrosis pathway, including inflammation, tumors, metabolic diseases and neurodegenerative diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2258671-03-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160169. | |
| Necrostatin-1 | Necrostatin-1 (Nec-1) is a potent and cross the blood-brain barrier necroptosis inhibitor with an EC50 of 490 nM in Jurkat cells. Necrostatin-1 inhibits RIP1 kinase (EC50=182 nM). Necrostatin-1 is also an IDO inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Nec-1. CAS No. 4311-88-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15760. | |
| Necrostatin 2 | Necrostatin 2 is a potent necroptosis inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM. Necrostatin 2 is also a RIPK1 inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 852391-19-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-14622. | |
| Necrostatin 2 racemate | Necrostatin 2 racemate (Nec-1S), the Necrostatin-1 (HY-15760) stable, is a potent and specific RIPK1 inhibitor lacking the IDO-targeting effect[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Necrostatin 1S; Nec-1S; 7-Cl-O-Nec1. CAS No. 852391-15-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14622A. | |
| Necrostatin 2 (S enantiomer) | Necrostatin 2 S enantiomer is the S enantiomer of Necrostatin 2 (HY-14622). Necrostatin 2 S enantiomer inhibits TNF-α-induced necroptosis in Jurkat T cells. Necrostatin 2 S enantiomer can be used for the research of ischemic brain injury (stroke)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 852391-20-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-14622B. | |
| Necrosulfonamide | Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinsons disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1360614-48-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100573. | |
| Necrosulfonamide-d4 | Necrosulfonamide-d4 is the deuterium labeled Necrosulfonamide (HY-100573). Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinsons disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways. Uses: Scientific research. Category: Signaling pathways. CAS No. 1795144-22-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-100573S. | |
| NecroX-5 | NecroX-5 is a derivative of the NecroX, reduces intracellular calcium concentration, and possesses anti-inflammatory and anti-cancer activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 1383718-29-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104015. | |
| NecroX-7 | NecroX-7 is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 can be used graft-versus-host disease (GVHD) research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1120332-55-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124750. | |
| Ned 19 | Ned 19 is a selective membrane-permeant non competitive NAADP antagonist and inhibits NAADP-mediated Ca2+ signaling, with an IC50 of 65 nM[1]. Ned 19 strongly inhibits tumor growth and vascularization as well as lung metastases in mice[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 874374-25-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-103316A. | |
| Nedisertib | Nedisertib (Peposertib) is an orally active selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of less than 3 nM. Nedisertib also acts as a modulator of ABCG2, capable of reversing ABCG2-mediated multidrug resistance (MDR), thus providing new strategies for combination therapy. By inhibiting DNA double-strand break repair, Nedisertib can enhance the efficacy of chemotherapy and radiotherapy. Nedisertib exhibits antitumor activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Peposertib; M3814. CAS No. 1637542-33-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101570. | |
| Nedizantrep | GDC-6599 is an orally active TRPA1 inhibitor, with IC50 values of 5.3 nM in humans, 6.6 nM in rats, 9.3 nM in dogs, 7.2 nM in monkeys, and 15 nM in guinea pigs. GDC-6599 can be used in the research of neuropathic pain and respiratory diseases such as asthma and chronic cough[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GDC-6599. CAS No. 2376824-99-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156684. | |
| Ned-K | Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR)-induced Ca2+ oscillations in cardiomyocytes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2250019-90-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131041. | |
| Nedometinib | Nedometinib (NFX-179) is a specific MEK1 inhibitor with an IC50 of 135 nM. Nedometinib inhibits p-ERK, MAPK. Nedometinib exerts anticancer activity against squamous cell carcinoma. Nedometinib can be used for research in dermatosis, neurofibromatosis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NFX-179. CAS No. 2252314-46-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-156625. | |
| Nedosiran sodium | Nedosiran (DCR-PHXC) sodium is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran sodium represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran sodium is a GalNAc-dsRNA conjugate[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DCR-PHXC sodium. CAS No. 2247026-22-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-132606A. | |
| Nefazodone | Nefazodone is an orally active phenylpiperazine antidepressant. Nefazodone can potently and selectively block postsynaptic 5-HT2A receptors, and moderately inhibit 5-HT and noradrenaline reuptake. Nefazodone can also relieve the adverse effects of stress on the the immune system of mice. Nefazodone has a high affinity for CYP3A4 isoenzyme, which indicates that it has certain risk of agent-agent interaction[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 83366-66-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119209. | |
| Nefazodone hydrochloride | Nefazodone hydrochloride (BMY-13754) is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively). Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMY-13754; MJ-13754-1. CAS No. 82752-99-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B1396. | |
| Neferine | Neferine is a major bisbenzylisoquinline alkaloid. Neferine strongly inhibits NF-κB activation. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Neferine. CAS No. 2292-16-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0441. | |
| Nefiracetam | Nefiracetam is a cognition-enhancing agent. Nefiracetam is an activator of nAChR, N-methyl-D-aspartate receptor (NMDAR), mGluR5, PKC, gamma-aminobutyric acid (GABA), and N/L-type Ca2+ channels. Nefiracetam promotes neuroplasticity and enhances neuroprotection. Nefiracetam can be used in Alzheimer's disease, epilepsy, and cerebral ischemia research[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DM9384; DZL-221. CAS No. 77191-36-7. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-B0340. | |
| Neflamapimod | Neflamapimod (VX-745) is a potent, blood-brain barrier penetrant, highly selective inhibitor of p38α inhibitor with an IC50 for p38α of 10 nM and for p38β of 220 nM. Neflamapimod (VX-745) possesses anti-inflammatory activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VX-745. CAS No. 209410-46-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10328. | |
| N-Eicosane-d42 | N-Eicosane-d42 is the deuterium labeled N-Eicosane[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 62369-67-9. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-W094847S. | |
| Neihulizumab | Neihulizumab (ALTB-168) is an immune checkpoint agonistic antibody that binds to human CD162 (PSGL-1), leading to downregulation of activated T-cells. Neihulizumab can be uesd for steroid-refractory acute graft-versus-host-disease (SR-aGVHD), psoriasis, psoriatic arthritis and ulcerative colitis research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALTB-168; Anti-PSGL1/CD162 Reference Antibody (neihulizumab); AbGn-168. CAS No. 2158362-38-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P99378. | |
| NEK7 degrader-1 | NEK7 degrader-1 is a NEK7 molecular glue degrader with a DC50 of 9 ?nM. NEK7 degrader-1 dose-dependently inhibits caspase-1 activity and IL-&Lota;β release in macrophages in response to NLRP3 inflammasome activation. NEK7 degrader-1 can be used for autoinflammatory and autoimmune disorders like multiple sclerosis, neurodegeneraive diseases like Alzheimer's disease and cardiovascular and melabolic disorders like pericarditis and Type 2 diabetes research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3069891-91-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-176860. | |
| Neladalkib | Neladalkib (NVL-655) is an oral ALK inhibitor, the IC50 for Neladalkib in inhibiting ALK is 2.8 nM. Neladalkib promotes cell apoptosis and has anti-tumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NVL-655. CAS No. 2739866-40-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-156467. | |
| Nelarabine | Nelarabine (506U78) is a nucleoside analogue and can be used for the research of T cell acute lymphoblastic leukemia (T-ALL)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 506U78; GW 506U78; Nelzarabine. CAS No. 121032-29-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13701. | |
| Nelfinavir | Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AG1341. CAS No. 159989-64-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15287. | |
| Nelfinavir Mesylate | Nelfinavir Mesylate (AG 1343 Mesylate) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir Mesylate (AG 1343 Mesylate) is a broad-spectrum, anticancer agent[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AG 1343 Mesylate. CAS No. 159989-65-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15287A. | |
| Nelistotug | Nelistotug (GSK 6097608; GSK6097608) is a human IgG1κ antibody targeting CD96[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSK-6097608. CAS No. 2645437-82-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990053. | |
| Nelivaptan | Nelivaptan (SSR-149415) is a selective and orally active vasopressin V1b receptor antagonist (Ki: 3.7 and 1.3 nM for native and recombinant rat V1b receptors, respectively). Nelivaptan inhibits arginine vasopressin (AVP)-induced Ca2+ increase and corticotropin secretion. Nelivaptan can be used for research of stress, anxiety and depression[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SSR-149415. CAS No. 439687-69-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-10066. | |
| Nelotanserin | Nelotanserin is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: APD125. CAS No. 839713-36-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10559. | |
| Nelremagpran | MRGPRX4 modulator-2 (compound 1-55) is a potent MRGPR X4 modulator, possessing antagonist activity against MRGPR X4 with an IC50 < 100 nM. MRGPRX4 modulator-2 can be used for researching autoimmune diseases such as psoriasis, multiple sclerosis, Steven Johnsons Syndrome, and other chronic itch conditions[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MRGPRX4 modulator-2. CAS No. 2492595-24-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147051. | |
| Nelutroctiv | Nelutroctiv (CK-136) is an orally active and selective cardiac troponin activator. Nelutroctiv activates cardiac sarcomeres by enhancing the sensitivity of troponin to calcium ions and promoting the interaction between actin and myosin. Nelutroctiv enhances cardiac contractility. Nelutroctiv can be used in the researches for cardiovascular diseases with impaired cardiac contractile function[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CK-136. CAS No. 2299177-09-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147292. | |
| Nemadectin | Nemadectin (CL-287088), an orally active broad-spectrum endectocide, is highly efficacious against natural infections of all the major canine gastrointestinal helminthes. Anthelmintic activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CL-287088; LL-F28249 α. CAS No. 102130-84-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-112542. | |
| Nemadipine-A | Nemadipine-A is a specific inhibitor of the EGL-19 L-type Ca2+ channel[1]. Nemadipine-A, a cell-permeable L-type calcium channel inhibitor, sensitizes TRAIL-resistant cancer cells to this ligand[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 54280-71-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg. Product ID: HY-126583. | |
| Nemifitide diTFA | Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action[1]. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF)[2]. Nemifitide diTFA can cross the blood-brain barrier[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: INN 00835 diTFA. CAS No. 204992-09-6. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 50 mg. Product ID: HY-105077A. | |
| Nemolizumab | Nemolizumab (CIM331) is a humanized monoclonal antibody that targets the human interleukin-31 receptor a, preventing interleukin-31 (IL-31) from binding to its receptor and the subsequent signaling. Nemolizumab can help reduce itching and sleep disturbances, and it is being studied for atopic dermatitis (AD)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CIM331; CD14152. CAS No. 1476039-58-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99162. | |
| Nemtabrutinib | Nemtabrutinib (ARQ 531) is a reversible non-covalent and orally active inhibitor of Brutons Tyrosine Kinase (BTK), with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ARQ-531; MK-1026. CAS No. 2095393-15-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112215. | |
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