MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Navitoclax (Standard) | Navitoclax (Standard) is the analytical standard of Navitoclax. This product is intended for research and analytical applications. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABT-263 (Standard). CAS No. 923564-51-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10087R. |  |
| Navivumab | Navivumab (CT-P23) is a monoclonal antibody targeting the hemagglutinin (HA) of influenza A virus. Navivumab binds to the HA2 stem fusion domain and the low-variability HA2 region of influenza viruses. Navivumab neutralizes influenza A viruses of subtypes H1, H2, H5, and H9. Navivumab is applicable to research related to influenza and influenza A[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CT-P23. CAS No. 1443004-16-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99750. | |
| Navlimetostat | Navlimetostat is a potent, orally active, selective PRMT5-MTA complex inhibitor, with IC50 of 3.6 and 20.5 nM for PRMT5-MTA and PRMT5. Navlimetostat binds to the PRMT5-MTA complex, with KD value of 0.14 pM. Navlimetostat shows antineoplastic activity in vitro and in vivo, and can be used for cancer study[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MRTX-1719; BMS-986504. CAS No. 2630904-45-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139611. | |
| Navoximod | Navoximod (GDC-0919; NLG-?919) is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GDC-0919; NLG-919. CAS No. 1402837-78-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18770B. | |
| Navtemadlin | Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMG 232; KRT-232. CAS No. 1352066-68-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12296. | |
| Naxitamab | Naxitamab (Hu3F8) is a humanized monoclonal antibody targeting the disialoganglioside GD2. Naxitamab can be used in research of neuroblastoma, osteosarcoma and other GD2-positive cancers[1]. Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: Naxitamab-gqgk; Humanized 3F8; Hu3F8. CAS No. 1879925-92-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99206. | |
| NAZ2329 | NAZ2329, the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), allosterically and preferentially inhibits PTPRZ (IC50=7.5 μM for hPTPRZ1) and PTPRG (IC50=4.8 μM for hPTPRG) over other PTPs. NAZ2329 binds to the active D1 domain and more potently inhibits PTPRZ-D1 fragment (IC50 of 1.1 μM) than the whole intracellular (D1?+?D2) fragment (IC50 of 7.5 μM). NAZ2329 can effectively inhibit tumor growth of the glioblastoma cells and suppress stem cell-like properties[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2809469-05-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103693. | |
| Nazartinib | Nazartinib (EGF816) is a covalent mutant-selective EGFR inhibitor, with Ki and Kinact of 31 nM and 0.222 min-1 on EGFR(L858R/790M) mutant, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EGF816. CAS No. 1508250-71-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-12872. | |
| N-(Azido-PEG2)-N-Boc-PEG3-NHS ester | N-(Azido-PEG2)-N-Boc-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG2)-N-Boc-PEG3-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2093153-85-4. Pack Sizes: 100 mg; 250 mg. Product ID: HY-140559. | |
| N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester | N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2100306-76-9. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-140581. | |
| NB-3 | NB-3 is a nicotinamide adenine dinucleotide (NAD) hydrolase SARM1 inhibitor. NB-3 intercepts NAD hydrolysis and undergoes covalent conjugation with the reaction product adenosine diphosphate ribose (ADPR). The resulting small-molecule ADPR adducts are highly potent and confer compelling neuroprotection in neurological injury[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3109123-46-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-171213. | |
| NB-598 | NB-598 is a potent and competitive inhibitor of squalene epoxidase (SE), and suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 131060-14-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16343. | |
| NB-598 Maleate | NB-598 Maleate is a potent and competitive inhibitor of squalene epoxidase (SE), and suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 (Maleate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 155294-62-5. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-16343C. | |
| NB-7 | NB-7 (example 12) is a potent and orally active SARM1 inhibitor with an IC50 < 1 μM. NB-7 can be used for neurological disorders research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2665712-31-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-203012. | |
| NBD-Cl | NBD-Cl is a nonfluorescent reagent which becomes highly fluorescent after reaction with thiol or amino groups[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NBD chloride. CAS No. 10199-89-0. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-D0042. | |
| NBD-Fructose | NBD-Fructose is a fluorescent derivative of Fructose (HY-N0395) that is formed by coupling NBD-chloride with the amine group of amino fructose (EX/Em=472/538 nm)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 940961-04-6. Pack Sizes: 500 μg; 1 mg. Product ID: HY-123067. | |
| NBDHEX | NBDHEX is a potent glutathione S-transferase P1-1 (GSTP1-1) inhibitor. NBDHEX induces apoptosis of tumor cells. NBDHEX acts as an anticancer agent by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the GSTP1-1 and key signaling effectors. NBDHEX can also act as late-phase autophagy inhibitor[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 787634-60-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135318. | |
| NBD-PE | NBD-PE is an effective lipid fluorescent probe (Excitation/Emission: 465/535 nm; Color: Green). NBD-PE offers a wide array of applications in membrane and cell biology[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 178119-00-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-D1683. | |
| NBD-Pen | NBD-Pen is the first fluorescence probe for lipid radicals with high selectivity and sensitivity (λex: 470 nm, λem: 530 nm). NBD-Pen specifically detects lipid derived radicals over other reactive species present in biological systems, including H2O2, ClO-, O2-?, and ?OH. NBD-Pen directly detects lipid radicals in living cells by turn-on fluorescence. NBD-Pen decreases inflammation, apoptosis, and oxidative stress markers. NBD-Pen can be studied in various disease models such as hepatic carcinoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1955505-54-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-129109. | |
| NBD peptide | NBD peptide inhibits NF-κB signaling pathway through inhibition of the NEMO-IKK complex combination. NBD peptide exhibits anti-inflammatory efficacy through block of pro-inflammatory cytokines production. NBD peptide exhibits immunosuppressive activity through regulation of immune cells. NBD peptide enhances its transmembrane ability by combining with cell-penetrating peptide HIV-TAT[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 371915-62-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10839. | |
| N-Benzoyl-(2R,3S)-3-phenylisoserine | N-Benzoyl-(2R,3S)-3-phenylisoserine is a Taxol C-13 Side Chain and crucial for the strong antitumor activity of Taxol[1]. Uses: Scientific research. Category: Natural products. CAS No. 132201-33-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2380. | |
| N-Benzoylcytidine | N-Benzoylcytidine is a modified cytidine analogue that can be phosphorylated by uracil-cytidine kinase (UCK1 and UCK2). N-Benzoylcytidine can be used to synthesize 2-OH protective groups for solid-phase RNA synthesis, as well as synthetic oligonucleotides for UV induction and targeted gene silencing in zebrafish embryos[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 13089-48-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 25 g. Product ID: HY-78574. | |
| N-Benzoyl-DL-arginine-4-nitroanilide hydrochloride | N-Benzoyl-DL-arginine-4-nitroanilide hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Category: Signaling pathways. CAS No. 911-77-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-W008953. | |
| N-Benzoyl-L-leucine | N-Benzoyl-L-leucine is a leucine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1466-83-7. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg; 1 g; 5 g. Product ID: HY-W142035. | |
| N-β-alanyldopamine hydrochloride | N-β-alanyldopamine hydrochloride (NBAD hydrochloride) is the major dopamine derivative in haemolymph[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NBAD hydrochloride. CAS No. 58077-93-3. Pack Sizes: 10 mM * 1 mL in Water; 25 mg; 50 mg; 100 mg. Product ID: HY-136537A. | |
| NBI-31772 | NBI-31772 is a non-selective IGFBP inhibitor (Ki=47 nM). NBI-31772 has neuroprotective effects and reduces infarct volume during cerebral ischemia. NBI-31772 can also restore or enhance proteoglycan synthesis in osteoarticular chondrocytes. In addition, NBI-31772 also increases the effect of IGF3 on zebrafish oocyte maturation[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 374620-70-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110135. | |
| NBI-74330 | NBI-74330 is a potent antagonist for CXCR3, and exhibits potent inhibition of (125I)CXCL10 and (125I)CXCL11 specific binding with Ki of 1.5 and 3.2 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 855527-92-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15320. | |
| NBI-961 | NBI-961 is a potent NEK2 inhibitor that inhibits proteasomal degradation. NBI-961 induces G2/mitosis arrest and apoptosis in diffuse large B cell lymphoma (DLBCL) cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2225902-98-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156437. | |
| N-Bis(2-hydroxypropyl)nitrosamine | N-Bis(2-hydroxypropyl)nitrosamine is a tumor model inducing agent and a metabolite of di-n-propylnitrosamine (DPN). N-Bis(2-hydroxypropyl)nitrosamine can be used to construct pancreatic cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Di(2-hydroxypropyl)nitrosamine; Diisopropanolnitrosamine. CAS No. 53609-64-6. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112085. | |
| NBM-T-BMX-OS01 | NBM-T-BMX-OS01 is an Osthole (HY-N0054) derivative. NBM-T-BMX-OS01 inhibits the phosphorylation of VEGFR2, FAK, Akt and ERK. NBM-T-BMX-OS01 has anti-angiogenic activity. NBM-T-BMX-OS01 has anti-cancer activity against colorectal cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMX. CAS No. 1246952-34-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-176498. | |
| N-Boc-4,4'-bipiperidine | N-Boc-4,4'-bipiperidine is a PROTAC linker that can be used to synthesize PROTAC BRD9 Degrader-5 (HY-145947)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 171049-35-7. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W129531. | |
| N-Boc-4-bromopiperidine | N-Boc-4-Bromopiperidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Category: Signaling pathways. CAS No. 180695-79-8. Pack Sizes: 10 g; 25 g. Product ID: HY-W001478. | |
| N-Boc-8-amino-octanoic acid | N-Boc-8-amino-octanoic acid (Boc-8-aminooctanoic acid) can be used as a PROTAC linker in the synthesis of PROTACs. N-Boc-8-amino-octanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Boc-8-aminooctanoic acid. CAS No. 30100-16-4. Pack Sizes: 1 g; 5 g; 10 g; 25 g. Product ID: HY-W041856. | |
| N-Boc-PEG10-alcohol | N-Boc-PEG10-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2238844-74-9. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-W190857. | |
| N-Boc-PEG1-bromide | N-Boc-PEG1-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG1-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 164332-88-1. Pack Sizes: 100 mg; 250 mg; 500 mg. Product ID: HY-130503. | |
| N-Boc-PEG4-bromide | N-Boc-PEG4-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG4-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1076199-21-7. Pack Sizes: 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W046471. | |
| N-Boc-PEG9-alcohol | N-Boc-PEG9-alcohol is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG9-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2112731-44-7. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-W071583. | |
| N-Boc-undecane-1,11-diamine | tert-Butyl (11-aminoundecyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. tert-Butyl (11-aminoundecyl)carbamate can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine. Uses: Scientific research. Category: Signaling pathways. CAS No. 937367-26-5. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-W131541. | |
| NBQX | NBQX (FG9202) is a highly selective and competitive AMPA receptor antagonist. NBQX has neuroprotective and anticonvulsant activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FG9202. CAS No. 118876-58-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15068. | |
| NBQX disodium | NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FG9202 disodium. CAS No. 479347-86-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15068A. | |
| NBTGR | NBTGR (p-Nitrobenzylthioguanosine) is a potent inhibitor of nucleoside transport; inhibits adenosine uptake with a Ki of 70 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 13153-27-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108322. | |
| N-Butanoyl-L-homoserine lactone | N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm[1]. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa[2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: C4-HSL; N-Butyryl-L-homoserine lactone. CAS No. 67605-85-0. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-114816. | |
| N-Butyl-N-(4-hydroxybutyl)nitrosamine | N-Butyl-N-(4-hydroxybutyl)nitrosamine is a potent mutagen that can cause high-level of mutagenesis specifically in the epithelial cells (urothelial) of the urinary bladder. N-Butyl-N-(4-hydroxybutyl)nitrosamine is used to induce bladder cancer in rodents[1]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: BBN. CAS No. 3817-11-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g. Product ID: HY-W755252. | |
| N-Butyrylglycine | N-Butyrylglycine is a Glycine (HY-Y0966) derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 20208-73-5. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-113119. | |
| N-Butyrylglycine-d2 | N-Butyrylglycine-d2 is the deuterium labeled N-Butyrylglycine[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1219799-10-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-113119S1. | |
| NC03 | NC03 is a PI4K2A inhibitor and reducing agent. NC03 inhibits the activity of PI4K2A, thereby reducing the production of PI4P in the cellular compartments where PI4K2A functions. NC03 rapidly induces a decrease in PI4P pools in the Golgi and endosomal compartments. NC03 reduces PI4P production in Rab7-positive late endosomes[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 568558-66-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115675. | |
| NC1 | NC1 is a selective non-competitive and allosteric lymphoid-specific tyrosine phosphatase (LYP) inhibitor, with a Ki value 4.3 μM. NC1 allosterically regulates LYP/PTPN22 activity by restricting WPD loop movement. NC1 inhibits LYP activity in lymphoid T cells and enhances T-cell receptor signaling. NC1 can be used for the research of autoimmune diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 445406-82-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156659. | |
| NC9 | NC9 (Cbz-Lys(Acr)-PEG2-dansyl) is an irreversible transglutaminase (TG) inhibitor. NC9 inhibits osteoblast differentiation and mineralization. NC9 destabilizes microtubules. NC9 can be used for the research of osteoblast differentiation[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cbz-Lys(Acr)-PEG2-dansyl. CAS No. 1352090-52-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129126. | |
| N-Carbamoyl-L-aspartic acid | N-Carbamoyl-L-aspartic acid (L-Ureidosuccinic acid) is an important pyrimidine metabolic precursor and intermediate metabolite. N-Carbamoyl-L-aspartic acid reverses the growth inhibition of Ura+ strains induced by 2-thiouracil (with growth rate increasing linearly with its concentration), but fails to support the growth of uracil-requiring Ura- strains. N-Carbamoyl-L-aspartic acid inhibits the cell growth of *Saccharomyces cerevisiae* by suppressing the purine biosynthetic pathway at a pre-step of 5-aminoimidazole nucleotide synthesis. The growth inhibitory effect of N-Carbamoyl-L-aspartic acid on yeast can be alleviated by purines, and the sensitivity of strains is closely related to the activity level of dihydroorotase[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: L-Ureidosuccinic acid. CAS No. 13184-27-5. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg. Product ID: HY-128425A. | |
| NCB-0846 | NCB-0846 is an orally active, selective inhibitor for Wnt, that inhibits Traf2- and Nck-interacting kinase (TNIK) with an IC50 of 21?nM. NCB-0846 blocks TGF-β signaling pathway by inhibiting SMAD2/3 phosphorylation and nuclear translocation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1792999-26-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100830. | |
| N-CBZ-Phe-Arg-AMC hydrochloride | N-CBZ-Phe-Arg-AMC (Z-FR-AMC) hydrochloride is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Z-FR-AMC hydrochloride. CAS No. 70382-26-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P1759A. | |
| NCC-149 | NCC-149 is a selective HDAC8 inhibitor and can be used for neural differentiation research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1316652-41-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117348. | |
| NCGC00188636 | NCGC00188636 is a novel covalent pyruvate kinase (PYK) inhibitor. NCGC00188636 blocks nucleotide binding to the active site of pyruvate kinase. NCGC00188636 can be used for the research of the metabolism of many organisms and cell types. Uses: Scientific research. Category: Signaling pathways. CAS No. 1039980-33-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-138825. | |
| NCGC00229600 | NCGC00229600 is an allosteric inverse agonist of thyrotropin receptor (TSHR). NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenously expressed in Graves' disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1338824-20-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18286. | |
| NCGC00244536 | NCGC00244536 is a potent KDM4B inhibitor with an IC50 of 10 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: KDM4B Inhibitor B3. CAS No. 2003260-55-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101799. | |
| NCGC00378430 | NCGC00378430 is a potent SIX1/EYA2 interaction inhibitor. NCGC00378430 partially reverses transcriptional and metabolic profiles mediated by SIX1 overexpression and reverses SIX1-induced TGF-β signaling and epithelial-mesenchymal transition (EMT). NCGC00378430 inhibits SIX1-mediated breast cancer metastasis in a mouse model[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 920650-00-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-138657. | |
| NCGC00685960 | NCGC00685960 is a Nicotinamide N-methyltransferase (NNMT) inhibitor with an IC50 <10 ?nM. NCGC00685960 has potent antitumor activity. NCGC00685960 increases H3K27 trimethylation levels in ovarian cancer cells and inhibits α-SMA expression in NNMT-expressing ovarian fibroblasts. NCGC00685960 reduces 1-MNA levels, reverses SAM and H3K27 hypomethylation and significantly impairs collagen contractility in cancer-associated fibroblasts (CAFs). NCGC00685960 can be used for cancers research, such as ovarian cancer, breast cancer, colon cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3091000-99-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-175603. | |
| NCGC 607 | NCGC 607 is a noninhibitory small-molecule chaperone of glucocerebrosidase (GCase). NCGC 607 can increase GCase activity, reduce α-synuclein levels, and decrease glycolipid levels. NCGC 607 can be used in the research of Gaucher disease and Parkinson's disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1462267-07-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-120034. | |
| NCI-B16 | NCI-B16 is a small molecule RNA binder and inhibits HCV viral replication[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 802835-01-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-156215. | |
| NCR 631 | NCR 631 is a 3-HAO inhibitor and 3-hydroxyanthranilic acid (HY-W001171) analogue. NCR-631 has anticonvulsant properties. NCR-631shows a concentration-dependent protective effect against the anoxia[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 160911-12-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-177986. | |
| NCRW0005-F05 | NCRW0005-F05 is a potent GPR139 antagonist with an IC50 value of 0.21 μM. NCRW0005-F05 can be used to research diabetes, obesity and Parkinson's disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 342779-66-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128057. | |
| NCT-501 | NCT-501 is a reversible, non-competitive, selective, blood-brain barrier-permeable ALDH1A1 inhibitor with an IC50 of 40 nM. NCT-501 inhibits the AKT-β-catenin signaling pathway, induces necroptosis in nasopharyngeal carcinoma cells, suppresses their proliferation and inhibits stem cell spheroid formation. NCT-501 can be used in research related to nasopharyngeal carcinoma, esophageal squamous cell carcinoma and malignant tumors[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1802088-50-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18768. | |
| NCT-502 | NCT-502 is a human phosphoglycerate dehydrogenase (PHGDH) inhibitor, cytotoxic to PHGDH-dependent cancer cells, and reduces glucose-derived serine production, with an IC50 of 3.7 μM against PHGDH[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1542213-00-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117240. | |
| NCT-503 | NCT-503 is a blood-brain barrier-permeable, non-competitive PHGDH inhibitor with an IC50 of 2.5 μM against human PHGDH. NCT-503 reduces glucose-derived serine production and the incorporation of one-carbon units into nucleotides without decreasing PHGDH protein expression. NCT-503 prevents high selenium-induced insulin resistance in mice by regulating blood glucose and insulin levels and improving glucose tolerance, and also inhibits the growth of tumors overexpressing PHGDH. NCT-503 can be used in research related to insulin resistance and breast cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1916571-90-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-101966. | |
| NCT-504 | NCT-504 is a selective allosteric inhibitor of PIP4Kγ, with an IC50 of 15.8 μM. NCT-504 is potential for the research of Huntington's disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1222765-97-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136311. | |
| NCT-505 | NCT-505 is a potent and selective aldehyde dehydrogenase (ALDH1A1) inhibitor, with an IC50 of 7 nM, and weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 (IC50s, >57, 22.8, 20.1, >57 μM). Uses: Scientific research. Category: Signaling pathways. CAS No. 2231079-74-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-112277. | |
| NCT-506 | NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with an IC50 of 7 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2231098-99-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112278. | |
| NCT-58 | NCT-58 is a potent inhibitor of C-terminal HSP90. NCT-58 does not induce the heat shock response (HSR) due to its targeting of the C-terminal region and elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation. NCT-58 kills Trastuzumab-resistant breast cancer stem-like cells. NCT-58 induces apoptosis in HER2-positive breast cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2411429-33-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145102. | |
| ND-011992 | ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. ND-011992 inhibits respiratory complex I and bo3 oxidase in addition to bd-I and bd-II oxidases in E. coli strain BL21*Δcyo with the IC50 of 0.12, 2.47, 0.63 and 1.3 μM, respectively. ND-011992 can be used for tuberculosis study[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2446880-46-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155107. | |
| ND-336 | ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2, MMP-9, and MMP-14, with Kis of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1807453-83-3. Pack Sizes: 10 mM * 1 mL in DMSO; 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-124373. | |
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