MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| BMS-833923 | BMS-833923 (XL-139) is an orally biocompatible Smoothened (Smo) inhibitor with anti-tumor activity. It can inhibit the binding of BODIPY cyclopamine to SMO in a dose-dependent manner with an IC50 of 21 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: XL-139. CAS No. 1059734-66-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-13809. |  |
| BMS-906024 | BMS-906024 is an orally active and selective γ-secretase (gamma secretase) inhibitor. BMS-906024 is a potent pan-Notch receptors inhibitor with IC50s of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1401066-79-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-15670. | |
| BMS-911543 | BMS-911543 is a selective JAK2 inhibitor, with IC50s of 1.1 nM, less selective at JAK1, JAK3 and TYK2 (IC50, 75, 360, 66 nM, respectively). Uses: Scientific research. Category: Signaling pathways. CAS No. 1271022-90-2. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15270. | |
| BMS-935177 | BMS-935177 is a potent and selective reversible inhibitor of Brutons tyrosine kinase (Btk) with an IC50 of 3 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1231889-53-4. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101793. | |
| BMS-963272 | BMS-963272 is an orally active and selective MGAT2 inhibitor (IC50 = 7.1 nM), used for the study of metabolic disorders and inflammatory diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1441057-15-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-132924. | |
| BMS-984923 | BMS-984923, a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (Ki = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo signaling without affecting physiological glutamate signaling[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1375752-78-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122559. | |
| BMS-986020 | BMS-986020 (AM152) is a high-affinity and selective lysophosphatidic acid receptor 1 (LPA1) antagonist[1]. BMS-986020 inhibits bile acid and phospholipid transporters with IC50s of 4.8 μM, 6.2 μM, and 7.5 μM for BSEP, MRP4, and MDR3, respectively[2]. BMS-986020 has the potential for the treatment of idiopathic pulmonary fibrosis (IPF)[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AM152. CAS No. 1257213-50-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100619. | |
| BMS-986094 | BMS-986094 (INX-08189) is a potent inhibitor of hepatitis C virus (HCV) replication, with an EC50 of 35 nM at 24 h in Huh-7 cells. BMS-986094 is a phosphoramidate proagent of 6-O-methyl-2-C-methyl guanosine. BMS-986094 can be used for the research of chronic HCV infection[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: INX-08189. CAS No. 1234490-83-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13337. | |
| BMS-986120 | BMS-986120 is a first-in-class oral and reversible protease-activated receptor 4 (PAR4) antagonist, with IC50s of 9.5 nM and 2.1 nM in human and monkey blood, respectively. BMS-986120 has potent and selective antiplatelet effects[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1478712-37-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19837. | |
| BMS-986122 | BMS-986122 is a selective, potent positive allosteric modulator of the mu-opioid receptor (μ-OR). BMS-986122 shows potentiation of orthosteric agonist-mediated β-arrestin recruitment, adenylyl cyclase inhibition, and G protein activation. BMS-986122 potentiates DAMGO-mediated [35S]GTPγS binding in mouse brain membranes[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 313669-88-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-120645. | |
| BMS-986141 | BMS-98614 is an orally active, selective thrombin receptor protease-activated receptor-4 (PAR-4) antagonist with an IC50 value of 0.4 nM. BMS-98614 has excellent antithrombotic effect[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1478711-48-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-150790. | |
| BMS-986142 | BMS-986142 is a potent and highly selective reversible inhibitor of Bruton's tyrosine kinase (BTK) with an IC50 of 0.5 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1643368-58-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101856. | |
| BMS-986158 | BMS-986158 is a potent BET inhibitor with IC50s of 6.6 and 5 nM in NCI-H211 small cell lung cancer (SCLC) cells and MDA-MB231 triple negative breast cancer (TNBC) cells, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1800340-40-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101567. | |
| BMS-986176 | BMS-986176 (LX-9211) is a highly selective, brain-penetrant, potent AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2 nM. BMS-986176 can be used for neurodegenerative diseases research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LX-9211; AAK1-IN-1. CAS No. 1815613-42-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134829. | |
| BMS-986189 | BMS-986189 is a macrocyclic peptide PD-1/PD-L1 interaction with an IC50 of 1.03 nM inhibitor. BMS-986189 can be used for cancer research, such as human lung carcinoma cells L2987[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1629665-96-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P10375. | |
| BMS-986202 | BMS-986202 is a potent, selective and orally active Tyk2 inhibitor that binds to Tyk2 JH2 with an IC50 value of 0.19 nM and a Ki of 0.02 nM. BMS-986202 is remarkably selective over other kinases including Jak family members. BMS-986202 is also a weak inhibitor of CYP2C19 with an IC50 value of 14 μM. BMS-986202 can be used for IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus research. BMS-986202 is a de novo deuterium[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1771691-34-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131968. | |
| BMS-986224 | BMS-986224 is a potent, selective and orally active APJ receptor agonist (Kd = 0.3 nM). BMS-986224 exhibits similar receptor binding and signaling profile to (Pyr1) apelin-13. BMS-986224 has the potential for the research of heart failure[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2055200-88-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139485. | |
| BMS-986235 | BMS-986235 (LAR-1219) is a selective, orally active formyl peptide receptor 2 (FPR2) agonist, with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 has potential for the prevention of heart failure[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LAR-1219. CAS No. 2253947-47-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-131180. | |
| BMS-986238 | BMS-986238 is an orally active macrocyclic peptide PD-L1 inhibitor. BMS-986238 can be used in the research of tumors such as solid tumors and lymphomas[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2919596-13-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-172320. | |
| BMS-986260 | BMS-986260, an immuno-oncology agent, is a potent, selective, and orally active TGFβR1 inhibitor (IC50=1.6 nM). BMS-986260 displays exquisite selectivity for TGFβR1 over its isozyme TGFβR2, as well as in a panel of more than 200 kinases examined. BMS-986260 inhibits TGFβ mediated nuclear translocation of pSMAD2/3 in MINK and NHLF cells lines with an IC50 of 350 nM and 190 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2001559-19-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-W107024. | |
| BMS-986278 | BMS-986278 is a potent and orally active lysophosphatidic acid receptor 1 (LPA1) antagonist, with Kbs of 6.9 nM and 4.0 nM for human and mouse LPA1, respectively. BMS-986278 can be used for the research of pulmonary fibrotic diseases[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Admilparant. CAS No. 2170126-74-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-139853. | |
| BMS-986299 | BMS-986299 (compound 112) is a first-in-class NLRP3 inflammasome agonist with an EC50 of 1.28 μM. (patent WO2018152396A1). Uses: Scientific research. Category: Signaling pathways. CAS No. 2242952-69-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139396. | |
| BMS-986365 | BMS-986365 (CC-94676) is an orally active and selective targeted androgen receptor (AR) PROTAC degrader (DC50 of 10-40 nM). BMS-986365 is capable of inducing cereblon (CRBN) E3 ligase-dependent ubiquitination and degradation of the androgen receptor (AR), as well as various AR mutants. BMS-986365 shows no degradation of the close AR family members estrogen receptor (ER), progesterone receptor (PR), and glucocorticoid receptor (GR). BMS-986365 shows significant in vivo potency, degrading AR, inhibiting AR signaling, and restricting tumor growth in animal models of advanced prostate cancer. BMS-986365 can be used for the study of metastatic castration-resistant prostate cancer (mCRPC)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CC-94676. CAS No. 2446928-30-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-158101. | |
| BMS-986397 | BMS-986397 is a potent, selective, and orally active cereblon-based molecular glue degrader of casein kinase 1α (CK1α). BMS-986397 induces apoptosis and cell cycle arrest in acute myeloid leukemia (AML) cells. BMS-986397 is a promising agent for the investigation of AML and high-risk myelodysplastic syndromes (HR-MDS)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2564486-44-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-159646. | |
| BMS-986408 | BMS-986408 is an orally active inhibitor of DGKα and DGKζ, with IC50 values of 0.0003 μM and 0.002 μM, respectively. BMS-986408 activates intratumoral T cell responses, enhances the priming and expansion of tumor-reactive T cells in tumor-draining lymph nodes, and functions as an immunostimulant. BMS-986408 can be used in the research of tumors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2618418-12-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-159649. | |
| BMS-986458 | BMS-986458 is a highly selective, orally active cereblon-based BCL6 PROTAC degrader and antitumor agent. BMS-986458 selectively degrades BCL6 by binding cereblon to the BTB domain of BCL6, thereby regulating the cell cycle, antiproliferative and interferon signaling pathways, and upregulating the expression and distribution of CD20. BMS-986458 modulates the phenotype of follicular helper T cells and reduces circulating tumor DNA levels. The combination of BMS-986458 with CD20xCD3 bispecific antibody also enhances the efficiency of T cell tumor infiltration and expansion. BMS-986458 induces regression of BCL6-positive tumors and prolongs survival, and it is suitable for research related to B-cell non-Hodgkin lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, and relapsed/refractory lymphoma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3005272-36-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-172736. | |
| BMS-986463 | BMS-986463, a CRBN E3 ligase modulator (CELMoD), is a WEE1 kinase molecular glue degrader. BMS-986463 significantly inhibits tumor regression and reduces the level of phospho-CDK2. BMS-986463 can be used for advanced malignant solid tumors like non-small cell lung cancer (NSCLC) research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3025467-07-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-175749. | |
| BMS-986470 | BMS-986470, a HbF-activating CRBN E3 ligase modulator (CELMoD), is an orally active dual molecular glue degrader targeting ZBTB7A and WIZ. BMS-986470 has potent γ-globin induction activity. BMS-986470 can be used for sickle cell disease (SCD) research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3036554-12-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-175742. | |
| BMS CCR2 22 | BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist with excellent binding affinity (binding IC50 of 5.1 nM) and potent functional antagonism (calcium flux IC50 of 18 nM and chemotaxis IC50 of 1 nM)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 445479-97-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101908. | |
| BMSpep-57 | BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1629655-80-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P3143. | |
| BMT-090605 hydrochloride | BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2231664-45-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101290A. | |
| BMX-IN-1 | BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys496 in the BMX ATP binding domain with an IC50 of 8 nM, also targets the related Brutons tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMX kinase inhibitor. CAS No. 1431525-23-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-80002. | |
| BMY 7378 | BMY 7378 is a selective antagonist of α1D-adrenoceptor (α1D-AR). BMY 7378 binds to membranes expressing the cloned rat α1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat α1A-AR (Ki=800 nM) or the hamster α1B-AR (Ki=600 nM). BMY 7378 is a 5-HT1A receptor partial agonist[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 21102-95-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100554. | |
| BN-82685 | BN-82685 is a a quinone-based CDC25 inhibitor with IC50 of 201 nM, 117 nM, 109 nM, 160 nM, 249 nM, for CDC25C, CDC25C-cat, CDC25A, CDC25B2, CDC25B3, respectively. BN-82685 plays an important role in cancer research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IRC-083065. CAS No. 477603-18-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121065. | |
| BNN6 | BNN6 is a thermoresponsive nitric oxide (NO) donor that often works by binding to a carrier. BNN6 decomposes under the heat stimulation generated by photothermal action, releasing high concentrations of NO, which exerts anti-tumor activity by inducing tumor cell apoptosis and inhibiting their repair. BNN6 can be used to synthesize the multifunctional biosensor BNN6-BiTiS3-iRGD, which exerts a synergistic anti-cancer effect with photothermal therapy (PTT)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 106476-75-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164117. | |
| BNTA | BNTA, a potent extracellular matrix (ECM) modulator, facilitates cartilage structural molecule synthesis on chondrocytes by activating superoxide dismutase 3 (SOD3). BNTA shows a promising potential for osteoarthritis alleviation by modulating cartilage generation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 685119-25-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136651. | |
| BO-264 | BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis. BO-264 has broad-spectrum antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2408648-20-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135960. | |
| Bobcat339 | Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2280037-51-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-111558. | |
| Bobcat339 hydrochloride | Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2436747-44-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-111558A. | |
| Boc-3,3'-biazetidine hemioxalate | Boc-3,3'-biazetidine (hemioxalate) is a PROTAC linker that can be used in the synthesis of PROTACs. Uses: Scientific research. Category: Signaling pathways. CAS No. 2059937-79-8. Pack Sizes: 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W127192. | |
| Boc-3,3-DicPr-Ala-OH | Boc-3,3-DicPr-Ala-OH is a chiral amino acid intermediate used in the synthesis of IL-17 modulators. Boc-3,3-DicPr-Ala-OH can be used to synthesize IL-17 modulators for research on diseases such as skin disorders[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2548967-22-0. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W453851. | |
| Boc-3-Pal-OH | Boc-3-Pal-OH is an alanine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 117142-26-4. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g; 5 g; 25 g. Product ID: HY-W008633. | |
| Boc-aminoxy-PEG4-acid | Boc-aminoxy-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2062663-68-5. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-140413. | |
| Boc-Arg-Val-Arg-Arg-AMC hydrochloride | Boc-Arg-Val-Arg-Arg-AMC hydrochloride (Boc-RVRR-AMC) is a synthetic fluorogenic substrate that is efficiently cleaved by furin[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Boc-RVRR-AMC. CAS No. 136132-77-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P4548. | |
| Bocconoline | Bocconoline is a potent early endosome antigen 1 (EEA1) inhibitor. Bocconoline can be isolated from Macleaya cordata. Bocconoline can be used for the research of Parkinsons disease (PD)[1]. Uses: Scientific research. Category: Natural products. CAS No. 32906-88-0. Pack Sizes: 1 mg. Product ID: HY-150058. | |
| Boc-Cystamine | Boc-Cystamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 485800-26-8. Pack Sizes: 250 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-140098. | |
| Boc-D-Ala(3,3-diphenyl)-OH | Boc-D-Ala(3,3-diphenyl)-OH is a phenylalanine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 143060-31-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W008432. | |
| Boc-D-Arg(Pbf)-OH | Boc-D-Arg(Pbf)-OH is an arginine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 186698-61-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g. Product ID: HY-W062304. | |
| BOC-D-FMK | Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor. Boc-D-FMK inhibits apoptosis stimulated by TNF-α with an IC50 of 39 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 634911-80-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13229. | |
| Boc-dPhe-Leu-dPhe-Leu-Phe | Boc-dPhe-Leu-dPhe-Leu-Phe (Boc-fLfLF) is a selective N-formyl peptide receptor1 (FPR1) antagonist. Boc-dPhe-Leu-dPhe-Leu-Phe inhibits fMIFL(HY-P0224)-induced NADPH oxidase activity. Boc-dPhe-Leu-dPhe-Leu-Phe can be used for the study of inflammation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 148182-34-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1795. | |
| Boceprevir | Boceprevir (EBP 520) is a potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with a Ki of 14 nM in both enzyme assay and an EC90 of 350 nM in cell-based replicon assay[1][2][3][4][5]. Boceprevir inhibits SARS-CoV-2 3CLpro activity[6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EBP 520; SCH 503034. CAS No. 394730-60-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10237. | |
| BOC-FlFlF | BOC-FlFlF (Boc-Phe-dLeu-Phe-dLeu-Phe) is a selective FPR1 antagonist. Boc-FlFlF has an apparent dissociation constant (KD) of 230 nM as determined by the intracellular calcium mobilization assay. Boc-FlFlF can be used for the study of inflammation[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BOC2; Boc-Phe-dLeu-Phe-dLeu-Phe. CAS No. 66556-73-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2355. | |
| Boc-Gln-Arg-Arg-AMC acetate | Boc-Gln-Arg-Arg-AMC acetate is a fluorogenic substrate for the determination of protease activity. Boc-Gln-Arg-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2223665-74-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P4323A. | |
| Boc-Gln-Gly-Arg-AMC | Boc-Gln-Gly-Arg-AMC is a fluorogenic substrate for kallikrein (PKa), coagulation factor XIIa (FXIIa) and coagulation factor XIa (FXIa). Boc-Gln-Gly-Arg-AMC enables fluorescence-based activity assays for PKa, FXIIa and FXIa[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 113865-85-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4331. | |
| Boc-Glu-Lys-Lys-AMC | Boc-Glu-Lys-Lys-AMC is a sensitive fluorogenic substrate for urokinase-activated plasmin[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 73554-85-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P4319. | |
| Boc-Glycine | Boc-Glycine is a Glycine (HY-Y0966) derivative[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-tert-Butoxycarbonyl-2-aminoacetic acid; NSC 127669. CAS No. 4530-20-5. Pack Sizes: 10 mM * 1 mL in DMSO; 500 g. Product ID: HY-Y0978. | |
| Boc-Gly-Gly-NHS ester | Boc-Gly-Gly-NHS ester can be used to selectively attach small molecules to specific amino acid residues on proteins, creating conjugates that can be used for a variety of applications in drug discovery and diagnostic assays. Uses: Scientific research. Category: Signaling pathways. CAS No. 29248-48-4. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-W800659. | |
| Boc-Gly-Gly-Phe-Gly-OH | Boc-Gly-Gly-Phe-Gly-OH, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC). Uses: Scientific research. Category: Signaling pathways. CAS No. 187794-49-6. Pack Sizes: 100 mg; 250 mg; 1 g; 5 g; 10 g. Product ID: HY-P1449. | |
| Boc-His(Trt)-OH | Boc-His(Trt)-OH is a histidine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 32926-43-5. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g; 100 g; 500 g. Product ID: HY-W010788. | |
| Boc-Ile-Glu-Gly-Arg-AMC | Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC) is an activated factor X (FXa) specific fluorogenic peptide substrate used for Factor VIII determination[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IEGR-AMC. CAS No. 65147-06-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2008. | |
| Boc-Leu-Gly-Arg-AMC | Boc-Leu-Gly-Arg-AMC is a fluorogenic AMC substrate for the convertases. Boc-Leu-Gly-Arg-AMC can be used in enzymatic assays[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 65147-09-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P2237. | |
| Boc-LRR-AMC | Boc-LRR-AMC (Boc-Leu-Arg-Arg-AMC) is a fluorogenic substrate, which can be utilized for detecting the trypsin-like activity of the 26S proteasome or the 20S proteasome core[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Boc-Leu-Arg-Arg-AMC. CAS No. 109358-46-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-115391. | |
| Boc-Lys(Ac)-AMC | Boc-Lys(Ac)-AMC is a cell-permeable fluorometric HDAC substrate (Ex/Em = 355 nm/460 nm)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 233691-67-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138159. | |
| Boc-Lys(Fmoc)-OH | Boc-Lys(Fmoc)-OH is a lysine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 84624-27-1. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g; 100 g; 500 g. Product ID: HY-W005144. | |
| Boc-Lys-OH | Boc-Lys-OH is an amino acid derivative. Boc-Lys-OH plays a key role in peptide synthesis and redox activity research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 13734-28-6. Pack Sizes: 10 mM * 1 mL in Water; 25 g; 50 g; 100 g. Product ID: HY-W007618. | |
| Boc-MLF | Boc-MLF is a formyl peptide receptor (FPR) antagonist, and reduces superoxide production induced by fMLF with an IC50 of 0.63 μM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Boc-Met-Leu-Phe-OH. CAS No. 67247-12-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103473. | |
| Boc-N-amido-PEG3-acid | Boc-N-amido-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1347750-75-7. Pack Sizes: 1 g. Product ID: HY-140468. | |
| Boc-NH-C12-NH2 | Boc-NH-C12-NH2 is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 109792-60-1. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-133388. | |
| Boc-NH-C4-Br | Boc-NH-C4-Br is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 164365-88-2. Pack Sizes: 1 g; 5 g; 10 g; 25 g; 100 g. Product ID: HY-W007803. | |
| Boc-NH-PEG12-NH2 | Boc-NH-PEG12-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1642551-09-4. Pack Sizes: 100 mg; 250 mg; 1 g; 5 g. Product ID: HY-133355. | |
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