MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Bromoenol lactone | Bromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β) with an IC50 value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (6E)-Bromoenol lactone. CAS No. 88070-98-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107411. |  |
| Bromo-PEG2-C2-azide | Bromo-PEG2-C2-azide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bromo-PEG2-C2-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromo-PEG2-C2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 530151-56-5. Pack Sizes: 100 mg; 250 mg; 1 g; 5 g. Product ID: HY-130485. | |
| Bromo-PEG3-azide | Bromo-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromo-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1446282-43-4. Pack Sizes: 100 mg; 250 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-140820. | |
| Bromo-PEG3-C2-acid | Bromo-PEG3-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 782475-35-8. Pack Sizes: 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W039168. | |
| Bromo-PEG6-alcohol | Bromo-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 136399-05-8. Pack Sizes: 100 mg; 250 mg; 1 g; 5 g; 25 g. Product ID: HY-141215. | |
| Bromophenol blue | Bromophenol blue is an acid phthalein dye, and it is used as a tracking dye for electrophoresis. Bromophenol blue is also used as a pH indicator, with a transition range of pH 3 to 4.6. Bromophenol blue is used as a sensor for the determination of several compounds including ammonia, drugs, proteins and amino acids. The binding of Bromophenol blue to proteins is accompanied by the appearance of a strong absorbance at 610 nm[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 115-39-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g. Product ID: HY-B1571. | |
| Bromosporine | Bromosporine, a chemical probe, is a potent BET inhibitor with an IC50 value of 2.1 μM for PCAF. Bromosporine can arrest cell cycle and induce apoptosis in cancer cells. Bromosporine exhibits excellent antitumor activity in xenograft mice model when combined with 5-Fluorouracil (HY-90006). Bromosporine can increase CDK9 T-loop phosphorylation in HIV-1 latency models, resulting the protection of reactivate HIV-1 replication from latency. Bromosporine can be used to research colorectal cancer, acute myeloid leukemia (AML) and AIDS[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1619994-69-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15815. | |
| Bromperidol | Bromperidol (R-11333) possesses antipsychotic activity, with a high affinity for central dopamine receptors D2. Bromperidol can kill Mycobacteria in a synergistic manner with Spectinomycin[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R-11333. CAS No. 10457-90-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0901. | |
| Brompheniramine maleate | Brompheniramine ((±)-Brompheniramine) maleate is a potent and orally active antihistamine of the alkylamine class. Brompheniramine maleate is a selective histamine H1 receptor antagonist with a Kd of 6.06 nM. Brompheniramine maleate can block the hERG channels, calcium channels, and sodium channels with IC50s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine maleate has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (±)-Brompheniramine maleate. CAS No. 980-71-2. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B0480. | |
| Brontictuzumab | Brontictuzumab (OMP 52M51) is a monoclonal antibody (MAb) that inhibits Notch1 signal. Brontictuzumab selectively binds the negative regulatory region of the Notch1. Brontictuzumab inhibits tumor cell proliferation. Brontictuzumab can be used in the research of leukemia and lymphoma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OMP 52M51; Anti-Human NOTCH1 Recombinant Antibody. CAS No. 1447814-75-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99258. | |
| Brophenexin | Brophenexin (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin shows neuroprotective activity. Brophenexin prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. Brophenexin protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NMDAR/TRPM4-IN-2. CAS No. 2243506-33-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-139192. | |
| Br-PEG6-C2-NHBoc | Br-PEG6-C2-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2688072-13-9. Pack Sizes: 100 mg; 250 mg; 1 g; 5 g. Product ID: HY-138381. | |
| Brr2-IN-3 | Brr2-IN-3 is a potent and selective Brr2 helicase allosteric Inhibitor. Brr2-IN-3 inhibits helicase activity in dose-dependent manner with an IC50 value of 1.3 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2104030-82-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137820. | |
| Bruceantin | Bruceantin ((-)-Bruceantin) is a quassinoid found in B. javanica. Bruceantin activates caspase signaling pathway, causes the mitochondrial dysfunction, inhibits cell proliferation, induces cell differentiation and apoptosis. Bruceantin exhibits anti-leukemia and antiprotozoal activities[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Bruceantin; NCI165563; NSC165563. CAS No. 41451-75-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N0840. | |
| Bruceine A | Bruceine A (Dihydrobrusatol) is a natural quassinoid. Bruceine A is an inhibitor of parasites, NF-κB, and PFKFB4 (Kd: 44 nM). Bruceine A is an activator of P38α MAPK. Bruceine A has antiparasitic activity. Bruceine A has antitumor activity and inhibits cancer cell migration. Bruceine A blocks the cell cycle and induces apoptosis. Bruceine A can be used in parasites, pancreatic cancer, and breast cancer research[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dihydrobrusatol; NSC310616. CAS No. 25514-31-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0841. | |
| Bruceine B | Bruceine B inhibits protein synthesis and nucleic acid synthesis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Brucein B. CAS No. 25514-29-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N3013. | |
| Bruceine D | Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity[1][2]. Bruceine D has strong anthelmintic activity against D. intermedius with an EC50 value of 0.57 mg/L[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 21499-66-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N3014. | |
| Brusatol | Brusatol (NSC 172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent[1]. Brusatol increases cellular apoptosis[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC 172924. CAS No. 14907-98-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19543. | |
| Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT | Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (Formula V) is a agent-linker conjugate that composed of a potent topoisomerase I inhibitor and a linker to make an antibody agent conjugate (ADC), ABBV-969[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2857037-70-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-148820. | |
| Bryodulcosigenin | Bryodulcosigenin is an extract of the roots of Bryoniadioica with anti-inflammatory effect[1]. Uses: Scientific research. Category: Natural products. Alternative Names: 11-Oxomogrol. CAS No. 88930-16-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N4312. | |
| Bryostatin 1 | Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with Kis of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1 infection properties[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 83314-01-6. Pack Sizes: 10 μg. Product ID: HY-105231. | |
| BS3 Crosslinker | BS3 Crosslinker is an amine-reactive homobifunctional protein crosslinker. BS3 Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation. Uses: Scientific research. Category: Signaling pathways. CAS No. 82436-77-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124329. | |
| BS3 Crosslinker disodium | BS3 Crosslinker disodium is an amine-reactive homobifunctional protein crosslinker. BS3 Crosslinker disodium enables stable protein-protein, peptide, and biomolecule conjugation. Uses: Scientific research. Category: Signaling pathways. CAS No. 127634-19-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124329A. | |
| BSA Standard Solution (5 mg/mL) | BSA Standard Solution (5 mg/mL) is a bovine serum albumin solution commonly used as a standard for total serum protein detection. BSA Standard Solution (5 mg/mL) can be used for drawing standard curves and calibrating experiments in total protein assays. BSA Standard Solution (5 mg/mL) is also suitable for various biological experiments, including PCR detection inhibition, antibody desalting, chromatography control, SDS-PAGE electrophoresis, and calibration of UV spectrophotometers[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9048-46-8. Pack Sizes: 5 mg. Product ID: HY-NP002. | |
| BSc5367 | BSc5367 is a potent Nek1 inhibitor with an IC50 of 11.5 nM. NIMA-related protein kinase Nek1 is crucially involved in cell cycle regulation, DNA repair and microtubule regulation and dysfunctions of Nek1 play key roles in amyotrophic lateral sclerosis (ALS), polycystic kidney disease (PKD) and several types of radiotherapy resistant cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3029584-84-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144425. | |
| BSH-IN-1 | BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs) with IC50s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2553217-91-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-135659. | |
| BSJ-03-123 | BSJ-03-123 is a PROTAC connected by ligands for Cereblon and CDK as a potent and novel CDK6-selective small-molecule degrader. Uses: Scientific research. Category: Signaling pathways. CAS No. 2361493-16-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111556. | |
| BSJ-03-204 | BSJ-03-204 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-03-204 is a potent and selective Palbociclib-based CDK4/6 dual degrader (PROTAC), with IC50s of 26.9 nM and 10.4 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-03-204 does not induce IKZF1/3 degradation and has anti-cancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2349356-09-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136250. | |
| BSJ-04-122 | BSJ-04-122 is a covalent MKK4/7 dual inhibitor. BSJ-04-122 inhibits MKK4 and MKK7 with IC50 values of 4 nM and 181 nM, respectively. BSJ-04-122 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2513289-74-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152185. | |
| BSJ-04-132 | BSJ-04-132 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-04-132 is a potent and selective Ribociclib-based CDK4 degrader (PROTAC), with IC50s of 50.6 nM and 30 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-04-132 does not induce CDK6 and IKZF1/3 degradation. BSJ-04-132 has anti-cancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2349356-39-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136252. | |
| BSJ-05-037 | BSJ-05-037 is an ITK PROTAC degrader that effectively targets and degrades ITK in T-cell lymphoma cell lines. BSJ-05-037 blocks the activation of the NF-κB/GATA-3 signaling pathway, inhibits PLCγ1 phosphorylation, and reduces the proliferative capacity of T-cell lymphoma cells. BSJ-05-037 enhances the sensitivity of T-cell lymphoma cells to chemotherapy. In mouse models of T-cell lymphoma, BSJ-05-037 induces ITK degradation, reduces GATA-3 expression, decreases tumor volume, and reverses chemotherapy resistance. BSJ-05-037 is applicable to research related to T-cell lymphoma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2756388-01-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-185206. | |
| BSJ-4-116 | BSJ-4-116 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. BSJ-4-116 downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation). BSJ-4-116 exhibits potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor Olaparib (HY-10162)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2519823-34-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139039. | |
| BSJ-5-63 | BSJ-5-63 is a potent CDK12, CDK7, CDK9 PROTAC degrader. BSJ-5-63 BSJ-5-63 decreases the protein expression of CDK12, CDK7, CDK9, RNAPII, Cyclin K. BSJ-5-63 decreases the mRNA expression of BRCA1, BRCA2. BSJ-5-63 shows anticancer activity and has the potential for the research of prostate cancer (Pink: ligand for target protein (HY-150948); black: linker (HY-W140827); Blue: E3 ligase ligand (HY-112078))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2519823-37-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162706. | |
| BSPOTPE | BSPOTPE is the mixture of (E)-BSPOTPE (HY-W856375) and (Z)-BSPOTPE. BSPOTPE binds Human serum albumin (HSA) (HY-P1956), exhibits aggregation-induced emission (AIE) phenomenon. BSPOTPE shows selectivity for albumin (such as HSA and BSA), but has no obvious fluorescence response to other proteins and DNA. BSPOTPE can be used as fluorescent probe for HSA[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2046513-40-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W856375A. | |
| BT173 | BT173 is a potent homeodomain interacting protein kinase 2 (HIPK2) inhibitor. BT173 binds to HIPK2 and does not inhibit HIPK2 kinase activity but rather, interfered allosterically with the ability of HIPK2 to associate with Smad3. BT173 attenuates renal fibrosis through suppression of the TGF-β1/Smad3 pathway. BT173 can be studied in research for kidney diseases such as renal fibrosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2232180-74-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-128439. | |
| BT18 | BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF)[1]. BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 924811-53-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-111969. | |
| BT2 | BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM. BT2 binding to BDK triggers helix movements in the N-terminal domain, resulting in the dissociation of BDK from the branched-chain α-ketoacid dehydrogenase complex (BCKDC)[1]. BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 μM[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 34576-94-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-114855. | |
| BT317 | BT317 is a blood-brain transmissible mitochondrial Lon peptidase I (LonP1) and CT-L proteasome inhibitor. BT317 can increase the production of reactive oxygen species (ROS) and induce apoptosis in astrocytoma cells. BT317 has antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 38485-94-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158412. | |
| BT424 | BT424 is a specific HCK inhibitor. BT424 can regulate macrophage activation and autophagy in vitro. BT424 ameliorates inflammation and kidney fibrosis in UUO model[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2755180-37-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155657. | |
| BT44 | BT44 is a selective RET activator. BT44 can penetrate through the blood-brain barrier and can be used for the research of neurodegenerative disorders and diabetes mellitus[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 924759-42-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153175. | |
| BTA-1 | BTA-1 is an uncharged derivative of thioflavin-T. BTA-1 has a high affinity for Aβ fibrils and shows very good brain penetration and clearance[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 439858-28-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W278021. | |
| BTA-188 | BTA-188, a pyridazinyl oxime ether, is an orally active, potent inhibitor of rhinoviruses (HRV) and enterovirus (EV) 71 in vitro. BTA-188 inhibits HRV-2 replication with an IC50 of 0.8 nM and an IC90 of 11 nM. BTA-188 inhibits enterovirus with an IC50 of 82 and an IC90 of 109 nM. BTA-188 is a potential chemotherapeutic agent for infections caused by the viruses in the Picornaviridae[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 314062-80-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-162022. | |
| BTB06584 | BTB06584 is a selective and IF1-dependent mitochondrial F1Fo-ATPase inhibitor without compromising ATP synthesis. BTB06584 can delays ischaemic cell death[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 219793-45-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15877. | |
| BTB09089 | BTB09089 is a T cell death-associated gene 8 (TDAG8/GPR65) specific agonist. BTB09089 increases TDAG8 expression and regulates the cytokine production of T cells and macrophages[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 245728-44-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149164. | |
| BTdCPU | BTdCPU is a potent heme regulated inhibitor kinase (HRI) activator that promotes eIF2α phosphorylation and induces apoptosis in Dexamethasone (HY-14648) (Dex)-resistant cancer cells. BTdCPU can be used in the study of cancers such as multiple myeloma and Dex-resistant multiple myeloma[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1257423-87-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118266. | |
| BTD probe-1 | BTD probe-1 is a benzothiazine-based chemoproteomic probe and selective protein S-sulfenic acid (Cys-SOH) labeling agent. BTD probe-1 labels protein S-sulfenic acids in vitro in cell and tissue samples, and in situ in intact cells, enabling detection or enrichment of modified proteins/peptides. BTD probe-1 exhibits no cytotoxicity in cells at concentrations ≤1 mM. BTD probe-1 enables global, site-specific mapping and quantification of cysteine S-sulfenylation in complex proteomes with lower input material[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2095485-22-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-D2186. | |
| BTSA1 | BTSA1 is a potent, high affinity and orally active BAX activator with an IC50 of 250 nM and an EC50 of 144 nM. BTSA1 binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 314761-14-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123054. | |
| BTT-3033 | BTT-3033 is an orally active conformation-selective inhibitor of α2β1 (EC50: 130 nM) by binding to the α2I domain. BTT-3033 inhibits platelet binding to collagen I and cell proliferation, and induces cell apoptosis. BTT-3033 can be used in the research of prostate cancer, inflammation and cardiovascular disease[1][2][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1259028-99-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-110112. | |
| BTTAA | BTTAA is a Cu(I)-stabilizing ligand, whch performs potently with ubiquitin Glu18AzF. Uses: Scientific research. Category: Signaling pathways. CAS No. 1334179-85-9. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100486. | |
| BTTES | BTTES is a tris(triazolylmethyl)amine-based ligand for Cu(I) without apparent toxicity. BTTES IMPROVES the cycloaddition reaction rapidly in living systems[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1334179-86-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153419. | |
| BTTP | BTTP is a tris(triazolylmethyl)amine-based ligand. BTTP can accelerate the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), the prototypical reaction in click chemistry[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1341215-17-5. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W615104. | |
| BTX-A51 | BTX-A51 (Casein Kinase inhibitor A51) is a potent and orally active casein kinase 1α (CK1α) inhibitor. BTX-A51 induces leukemia cell apoptosis, and has potent anti-leukemic activities[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Casein Kinase inhibitor A51. CAS No. 2079068-74-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-123954. | |
| BTYNB | BTYNB is a structure-specific nucleic acid binder and IGF2BP1 inhibitor (with an IC50 of 5 μM against hBTYNB). BTYNB disrupts the IGF2BP1-RNA interaction and blocks its binding to oncogenic mRNAs such as c-Myc, MDM2, PD-L1. BTYNB completely blocks the INHBA-Smad2/3 pathway, disrupts the MYCN/IGF2BP1 loop, and thereby induces apoptosis and cell cycle arrest, effectively inhibiting the proliferation and survival of cancer cells. In addition, BTYNB acts as an immune activator and tumor microenvironment modulator, enhances T cell-mediated tumor killing, and produces significant synergistic effects with inhibitors of PD-1, BRD and BIRC5. BTYNB can be used in relevant research on various malignant tumors including ovarian cancer, neuroblastoma, leukemia and melanoma[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 304456-62-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-124447. | |
| BTZ043 | BTZ043 is an inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), with MICs of of 2.3 nM and 9.2 nM for M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1161233-85-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13579. | |
| Bucillamine | Bucillamine (SA96) is an orally active and potent sulfhydryl donor and antioxidant. Bucillamine is also an antirheumatic agent with antiangiogenic properties. Bucillamine can protect against Ischemia/reperfusion (I/R) injury in high-risk organ transplants. Bucillamine inhibits the production of VEGF. Bucillamine can be used for the research of choroidal neovascularization (CNV) and rheumatoid arthritis (RA)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SA96; Thiobutarit. CAS No. 65002-17-7. Pack Sizes: 10 mM * 1 mL in Water; 25 mg; 50 mg; 100 mg. Product ID: HY-118530. | |
| Bucindolol | Bucindolol is a β1-adrenergic receptor blocker, with intrinsic sympathomimetic activity, used in the research of heart failure[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 71119-11-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103214. | |
| Bucladesine hemicalcium | Bucladesine (Dibutyryl cAMP; DBcAMP) hemicalcium is a membrane-permeable 3, 5-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dibutyryl cAMP hemicalcium; DBcAMP hemicalcium. CAS No. 938448-87-4. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-B0764A. | |
| Bucladesine sodium | Bucladesine (Dibutyryl cAMP; DBcAMP) sodium is a membrane-permeable 3, 5-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dibutyryl cAMP sodium; DBcAMP sodium. CAS No. 16980-89-5. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B0764. | |
| Budesonide | Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 51333-22-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg. Product ID: HY-13580. | |
| Budesonide oleate (C18:1) | Budesonide oleate (C18:1) (Budesonide 21-oleate) is a prodrug of Budesonide (HY-13580), and can be used as the active ingredient of anti-inflammatory lipid nanoparticles for targeted delivery of anti-inflammatory agents[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Budesonide 21-oleate. CAS No. 102668-87-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-181133. | |
| Budigalimab | Budigalimab (ABBV 181; PR 1648817) is a humanized, recombinant IgG1 monoclonal antibody targeting programmed cell death 1 (PD-1) receptor. Budigalimab has an Fc mutation that reduces the inhibition of Fc receptor interactions and effector factors. Budigalimab can block the binding of PD-1 and PD-L1, which has anti-tumor activity. Budigalimab can be used in the study of solid tumors[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABBV 181; PR 1648817. CAS No. 2098225-93-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99489. | |
| Budiodarone tartrate | Budiodarone (ATI-2042) tartrate is a chemical analogue of Amiodarone (HY-14187) with balanced, multiple cardiac ion channel (potassium, sodium and calcium channels) inhibiting activity. Budiodarone tartrate is an antiarrhythmic agent[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ATI-2042 tartrate. CAS No. 478941-93-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14834A. | |
| Budoprutug | Budoprutug is an anti-CD19 human IgG1 κ monoclonal antibody[1]. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001). Uses: Scientific research. Category: Signaling pathways. Alternative Names: VB-119. CAS No. 2720478-38-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990729. | |
| Bufalin | Bufalin is an active component isolated from Chan Su, acts as a potent Na+/K+-ATPase inhibitor, binds to the subunit α1, α2 and α3, with Kd of 42.5, 45 and 40 nM, respectively[1][2]. Anti-cancer activity[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 465-21-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0877. | |
| Buforin II | Buforin II, derived from buforin I, a protein isolated from the stomach of the Asian toad Bufo bufo gargarizans, is a potent antimicrobial peptide. Buforin II has antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 172998-24-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1630. | |
| Bufotalin | Bufotalin is a steroid lactone isolated from Venenum Bufonis with potently antitumor activities. Bufotalin induces cancer cell apoptosis and also induces endoplasmic reticulum (ER) stress activation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 471-95-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N0878. | |
| Bufuralol | Bufuralol (Ro 3-4787) is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ro 3-4787. CAS No. 54340-62-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105124. | |
| Bufuralol hydrochloride | Bufuralol (Ro 3-4787) hydrochloride is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ro 3-4787 hydrochloride. CAS No. 60398-91-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105124A. | |
| Bulevirtide | Bulevirtide (Myrcludex B) is a NTCP inhibitor, a linear lipopeptide of 47 amino acids. Bulevirtide inhibits HBV and HDV entry into liver cells, blocks HBV infection in hepatocytes, and participates in HBV transcriptional suppression. Bulevirtide can be used in HDV infection and compensated cirrhosis research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Myrcludex B. CAS No. 2012558-47-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P3465. | |
| Buloxibutid | Buloxibutid (AT2 receptor agonist C21) is an orally active, selective angiotensin II type 2 receptor (AT2R) agonist, with a Ki value of 0.4 nM for porcine AT2R. Buloxibutid exerts effects such as vasodilation, anti-inflammation, anti-fibrosis (promoting the expression of collagenase MMP-13) and tissue repair mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway as well as the inflammatory NF-κB pathway. Buloxibutid can be used in research related to idiopathic pulmonary fibrosis, hypertension, and systemic sclerosis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AT2 receptor agonist C21. CAS No. 477775-14-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-100113. | |
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