MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Borocaptate sodium | Borocaptate sodium is a boron-containing compound that can be used as a therapeutic agent in boron neutron capture therapy (BNCT), exhibiting anticancer activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BSH. CAS No. 144885-51-8. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142041. |  |
| Borrelidin | Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei[1]. Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC50 of 24 μM[2]. Borrelidin is a potent angiogenesis inhibitor, with an IC50 of 0.8 nM. Borrelidin induces apoptosis in the tube-forming cells[3]. Borrelidin has strong antimalarial activities, with IC50s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum, respectively[4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Treponemycin. CAS No. 7184-60-3. Pack Sizes: 10 mM * 1 mL in Ethanol; 500 μg; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N6742. | |
| Bortezomib | Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM)[1][2]. Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs)[7]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PS-341; LDP-341; NSC 681239. CAS No. 179324-69-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10227. | |
| Bortezomib impurity 12 | Bortezomib impurity 12 is an impurity of Bortezomib (HY-10227). Uses: Scientific research. Category: Signaling pathways. CAS No. 886979-78-8. Pack Sizes: 10 mg. Product ID: HY-W048407. | |
| Bortezomib (Standard) | Bortezomib (Standard) is the analytical standard of Bortezomib. This product is intended for research and analytical applications. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM)[1][2]. Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs)[7]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PS-341 (Standard); LDP-341 (Standard); NSC 681239 (Standard). CAS No. 179324-69-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10227R. | |
| Borussertib | Borussertib, a chemical probe, is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1800070-77-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122913. | |
| BOS-172722 | BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 11 nM and 63 nM for MPS1 (1 mM ATP) and P-MPS1, respectively. BOS-172722 also has potential for the study of various forms of breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1578245-44-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112162. | |
| BOS-318 | BOS-318 is a potent, slowly dissociating, highly selective, and cell-permeable furin inhibitor with IC50 value of 1.9 nM. BOS-318 protects ENaC from subsequent activation by neutrophil elastase. BOS-318 can be used for the rsearch for CF lung disease[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2387633-15-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147140. | |
| Bosakitug | Bosakitug (BSI-045B) is an TSLP-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001). Bosakitug can be used in the research of inflammatory diseases such as moderate to severe atopic dermatitis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BSI-045B; TQC2731. CAS No. 2762183-23-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990906. | |
| Boscalid | Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 188425-85-6. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-119976. | |
| Boscalid-d4 | Boscalid-d4 is the deuterium labeled Boscalid. Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2468796-76-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-119976S. | |
| Boscalid (Standard) | Boscalid (Standard) is the analytical standard of Boscalid. This product is intended for research and analytical applications. Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 188425-85-6. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119976R. | |
| Bosentan | Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 147536-97-8. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-A0013. | |
| Bosentan hydrate | Bosentan hydrate is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 157212-55-0. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-A0013A. | |
| Bosutinib | Bosutinib is an orally active Src/Abl tyrosine kinase inhibitor with IC50 of 1.2 nM and 1 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SKI-606. CAS No. 380843-75-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 250 mg; 500 mg. Product ID: HY-10158. | |
| Bosutinib hydrate | Bosutinib hydrate is an oraly activel Src/Abl tyrosine kinase inhibito with IC50 of 1.2 nM and 1 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SKI-606 hydrate. CAS No. 918639-08-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10158A. | |
| Botensilimab | Botensilimab (AGEN 1181), a human anti-cytotoxic T-lymphocyte antigen 4 (CTLA-4) monoclonal antibody, is an innate and adaptive immune activator. Botensilimab can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AGEN 1181. CAS No. 2408310-37-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99484. | |
| Bovine Gelatin,suitable for cell culture | Bovine Gelatin, suitable for cell culture can be used for cell culture to induce cell attachment[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9000-70-8. Pack Sizes: 5 g; 10 g; 25 g; 50 g. Product ID: HY-Y1365D. | |
| Bovine Serum Albumin | Bovine Serum Albumin (BSA) is a 583-residue protein consisting of three homologous all-α domains, organized in a heart-shaped structure. BSA is a globular protein that is used in numerous biochemical applications. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Albumin bovine serum; BSA. CAS No. 9048-46-8. Pack Sizes: 500 mg; 1 g; 5 g; 10 g. Product ID: HY-D0842. | |
| Bovine Serum Albumin (Biotinylated) | Bovine Serum Albumin (Biotinylated) is a biotinylated bovine serum albumin that selectively binds to different vascular subsets in lymphoid tissue. Bovine Serum Albumin (Biotinylated) can be used as a histochemical probe, and a targeting ligand for drug delivery[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9048-46-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-NP002D. | |
| Bovine Serum Albumin (Low Endotoxin,Fatty acid free) | Bovine Serum Albumin (Low Endotoxin,Fatty acid free) (BSA) is a 583 amino acid globular protein and oligonucleotide binding protein composed of three homologous full α domains. Bovine Serum Albumin (Low Endotoxin,Fatty acid free) (BSA) blocks the overall binding of oligonucleotides to cells. Bovine Serum Albumin (Low Endotoxin,Fatty acid free) (BSA) regulates the development of hamster embryos and induces arthritis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Albumin bovine serum (Low Endotoxin,Fatty acid free); BSA (Low Endotoxin,Fatty acid free). CAS No. 9048-46-8. Pack Sizes: 1 g; 5 g; 10 g; 25 g. Product ID: HY-D0842A. | |
| Box5 | Box5 is a potent Wnt5a antagonist. Box5 inhibits Wnt5a signaling and inhibits Wnt5a-mediated Ca2+ release. Box5 inhibits cell migration. Box5 has the potential for the research of melanoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1206604-29-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-123071. | |
| Bozitinib | Bozitinib (PLB-1001) is a highly selective c-MET kinase inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) is a ATP-competitive small-molecule inhibitor, binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PLB-1001; CBT-101; Vebreltinib. CAS No. 1440964-89-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125017. | |
| BP-1-102 | BP-1-102 is an orally available, small-molecule inhibitor of transcription factor Stat3, with an IC50 of 6.8 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1334493-07-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-100493. | |
| BP79 | BP79 is a potent TSLP receptor inhibitor. BP79 disrupts TSLP-mediated ternary complex formation, blocks TSLPR-IL7Rα co-localization, binds and stabilizes TSLPR, and inhibits phosphorylated STAT3/6. BP79 suppresses immune cell infiltration, secretion of IL-13, IL-4. BP79 can be used for the research of inflammation diseases, such as atopic dermatitis, allergic asthma, and allergic rhinitis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3104965-33-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-206870. | |
| BPAM344 | BPAM344 is a kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a positive allosteric modulator (PAM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1204572-55-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129086. | |
| BPC 157 | BPC 157 is the 15-amino acide fragment of gastric peptide BPC. BPC 157 exhibits wound healing promoting and neuroprotective activity. BPC 157 maintains the integrity of the gastrointestinal mucosa without significant toxicity. BPC 157 acetate counteracts NSAIDs/insulin overdose/copper-induced toxicity. BPC 157 ameliorates specific (over)stimulated/damaged neurotransmitter systems-induced behavioral disorders through serotonergic and dopaminergic systems[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 137525-51-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105174. | |
| BPC 157 acetate | BPC 157 acetate is an orally active peptide. BPC 157 acetate exhibits multiple activities such as promoting wound healing, tendon healing, neuroprotection, and gastrointestinal protection. BPC 157 acetate can be used in the research of tendon injury, burn, gastric ulcer, and neurological diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1628202-19-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105174A. | |
| BP Fluor 488 cadaverine | BP Fluor 488 Cadaverine is a carboxyl/carbonyl reactive building block used widely to modify carboxylic groups in the presence of activators (e.g. EDC or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. Uses: Scientific research. Category: Signaling pathways. CAS No. 1178534-61-6. Pack Sizes: 1 mg. Product ID: HY-D2751. | |
| BP Fluor 488 DBCO | BP Fluor 488 DBCO is a popular labeling dye used in copper-free Click Chemistry reactions. It will react with the azide group in antibody, proteins, peptides, amino-modified oligos, and other target molecules. The dye has an excitation peak at 499 nm and an emission peak at 520 nm. The conjugates are widely used in microscopy, flow cytometry, and other applications. BP Fluor 488 is a pure 5-sulfonated rhodamine molecule and it eliminates the lot-to-lot variation caused by two isomers ratio differences. Uses: Scientific research. Category: Signaling pathways. CAS No. 2423960-92-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W800680. | |
| BPH-652 | BPH-652 is a S. aureus dehydrosqualene synthase (CrtM) inhibitor, with a Ki of 1.5 nM and an IC50 of 100-300 nM (S. aureus pigment formation)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 157124-84-0. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16115. | |
| BPHA | BPHA is a potent and orally active MMP-2, MMP-9 and MMP-14 inhibitor with IC50s of 12 nM, 16 nM and 17 nM, respectively. BPHA does not inhibit MMP-1, -3, and -7 (the IC50s are 974, >1000, and 795 nM, respectively). BPHA has antiangiogenic and antitumor effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 193807-60-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114785. | |
| BPK-21 | BPK-21, an active acrylamide, suppresses T cell activation through blockade of ERCC3 function. BPK-21 specifically targets C342 in the helicase ERCC3[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2305052-77-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141549. | |
| BPK-25 | BPK-25, an active acrylamide, promotes degradation of nucleosome remodeling and deacetylation (NuRD) complex proteins by a post-translational mechanism involving covalent protein engagement. BPK-25 inhibits TMEM173 activation by the cyclic dinucleotide ligand cGAMP[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2305052-86-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141550. | |
| BPKDi | BPKDi is an inhibitor of PKD. BPKDi inhibits three members of the PKD family, PKD1, PKD2, and PKD3, with IC50 values of 1 nM, 9 nM, and 1 nM, respectively. BPKDi blocks signal-dependent phosphorylation and nuclear export of class IIa HDACs in cardiomyocytes and concomitantly suppresses hypertrophy of these cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1201673-28-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-118052. | |
| BPO-27 racemate | BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1314873-02-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-19778A. | |
| BPR1K871 | BPR1K871 is a potent and selective dual FLT3/AURKA inhibitor with IC50s of 19 nM and 22 nM for FLT3 and AURKA, respectively, acts as a preclinical development candidate for anti-cancer therapy[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DBPR114. CAS No. 2443767-35-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100865. | |
| BPR1M97 | BPR1M97 is a dual-acting mu opioid receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptor agonist with Ki values of 1.8 and 4.2 nM, respectively. BPR1M97 shows high potency and blood-brain barrier penetration, and produces potent antinociceptive effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2059904-66-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128865. | |
| BPR3P0128 | BPR3P0128 is an orally active, non-nucleoside RNA-dependent RNA polymerase (RdRp) inhibitor that has been shown to inhibit the activity of various SARS-CoV-2 variants. The EC50 for SARS-CoV-2 and HCoV-229E are 0.62 μM and 0.14 μM. BPR3P0128 demonstrates effective anti-pancoronavirus activity within the submicromolar range. PR3P0128 shows synergistic antiviral activity when combined with Remdesivir (HY-104077)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1345406-09-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161356. | |
| BPTES | BPTES is an allosteric and selective glutaminase inhibitor with an IC50 of 0.16 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 314045-39-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-12683. | |
| BPTF-IN-BZ1 | BPTF-IN-BZ1, a BPTF inhibitor, possesses a high potency (Kd = 6.3 nM). Uses: Scientific research. Category: Signaling pathways. CAS No. 2766623-38-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132889. | |
| BPTU | BPTU (BMS-646786) is a non-nucleotide P2Y1 receptor allosteric antagonist with antithrombotic activity. BPTU is able to block the P2Y1 receptor located at the neuromuscular junction of the gastrointestinal tract[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-646786. CAS No. 870544-59-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13831. | |
| BpV(HOpic) | BpV(HOpic) is a potent and selective inhibitor of PTEN with an IC50 of 14 nM. Nanocarrier-BpV(HOpic) has neuroprotective activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Bisperoxovanadium. CAS No. 722494-26-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128693. | |
| BQ-123 | BQ-123 is a potent and selective endothelin A (ETA) receptor antagonist with an IC50 of 7.3 nM and a Ki of 25 nM. BQ-123 inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 136553-81-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12378. | |
| BQ-788 | BQ-788 is a potent, selective ETB receptor antagonist with IC50 of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC cells with IC50 of 1300 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 173326-37-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15894A. | |
| BQ-788 sodium salt | BQ-788 sodium salt is a potent and selective ETB receptor antagonist, inhibiting ET-1 binding to ETB receptors with an IC50 of 1.2 nM in human Girrardi heart cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 156161-89-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15894. | |
| BQU57 | BQU57 is a selective inhibitor of RalA/RalB small GTPases, with a binding potency (Kb) of 7.7 μM for RalB-GDP. BQU57 can block its interaction with effector proteins (such as SEC5 and EXO84), inhibiting tumor cell migration, invasion and non-adherent growth. BQU57 downregulates the NF-κB signaling pathway, reduces the expression of IL-6, IL-8 and MMP-13, and inhibits apoptosis by regulating the Bcl-2/Bax balance. BQU57 also protects the extracellular matrix by inhibiting the Ral/NF-κB pathway and can be used for the study of degenerative diseases. BQU57 exhibits significant antitumor activity in triple-negative breast cancer (TNBC) models, inhibiting orthotopic tumor growth and lung metastasis and enhancing paclitaxel chemotherapy sensitivity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1637739-82-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12875. | |
| Braco-19 | Braco-19 is a potent telomerase/telomere inhibitor, preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding ligand, stabilizing G-quadruplexes formation at the 3V telomeric DNA overhang and produce rapid senescence or selective cell death. Braco-19 is also a HAdV virus replication inhibitor[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 351351-75-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15523. | |
| Braco-19 trihydrochloride | Braco-19 trihydrochloride is a potent telomerase/telomere inhibitor, preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding ligand, stabilizing G-quadruplexes formation at the 3V telomeric DNA overhang and produce rapid senescence or selective cell death. Braco-19 is also a HAdV virus replication inhibitor[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1177798-88-7. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15523A. | |
| Bradanicline | Bradanicline (TC-5619) is an orally active agonist of α7 nAChR with moderate blood-brain barrier penetration. Bradanicline exhibits high affinity and subtype selectivity for human α7 nAChR. Bradanicline possesses antitussive activity that depends on sustained receptor binding and activation. Bradanicline requires systemic administration to dose-dependently inhibit cough induced by citric acid, bradykinin and inhaled nicotine. Bradanicline is well tolerated in preclinical studies and is widely used in research related to chronic refractory cough[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TC-5619. CAS No. 639489-84-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18060. | |
| Bradykinin | Bradykinin is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 58-82-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0206. | |
| Bradykinin (1-5) | Bradykinin (1-5) is a major stable metabolite of Bradykinin (HY-P0206), formed by the proteolytic action of angiotensin-converting enzyme (ACE)[1]. Bradykinin (1-5) inhibits α- and γ-thrombin-induced platelet aggregation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 23815-89-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1488. | |
| Bradykinin (1-6) | Bradykinin (1-6) is an amino-truncated Bradykinin peptide. Bradykinin (1-6) is a stable metabolite of Bradykinin, cleaved by carboxypeptidase Y (CPY). Uses: Scientific research. Category: Signaling pathways. CAS No. 23815-88-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1469. | |
| Bradykinin (1-7) | Bradykinin (1-7) is an amino-truncated Bradykinin peptide. Bradykinin (1-7) is a metabolite of Bradykinin, cleaved by endopeptidase. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Bradykinin Fragment 1-7. CAS No. 23815-87-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P1484. | |
| Bradykinin acetate | Bradykinin acetate is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin acetate can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6846-3-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0206A. | |
| Braftide | Braftide is an allosteric inhibitor for BRAF kinase by targeting the dimer interface of BRAF kinase and inhibiting the formation of BRAF dimers. Braftide inhibits wild-type BRAF and oncogenic BRAFG469A with IC50 of 364 nM and 172 nM, respectively. Braftide inhibits MAPK signaling pathway, inhibits proliferation of KRAS mutant tumor cells (EC50 is 7.1 and 6.6 μM, for HCT116 and HCT-15), in combination of TAT sequence. Braftide can be used for cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2411851-64-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P10436. | |
| Brain Derived Basic Fibroblast Growth Factor (1-24) | Brain Derived Basic Fibroblast Growth Factor (1-24) (FGF basic 1-24) is a synthetic peptide, shows anti-bacterial and anti-HBV activities. Brain Derived Basic Fibroblast Growth Factor (1-24) can be used in infection disease and immune disease research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FGF basic (1-24). CAS No. 211362-85-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3601. | |
| Brain Natriuretic Peptide-45, mouse | Brain Natriuretic Peptide-45, mouse (BNP-45, mouse) is a 45-amino-acid peptide derived from the mouse BNP prohormone, which exhibits natriuretic, diuretic, and vasoactive effects. Brain Natriuretic Peptide-45, mouse contains all amino acid residues deemed critical for the biological activity of natriuretic peptides. Brain Natriuretic Peptide-45, mouse possesses hypotensive and diuretic activities[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BNP-45, mouse. CAS No. 1816939-52-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2469. | |
| Branaplam | Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LMI070; NVS-SM1. CAS No. 1562338-42-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-19620. | |
| Branaplam hydrochloride | Branaplam (LMI070; NVS-SM1) hydrochloride is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam hydrochloride inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam hydrochloride elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LMI070 hydrochloride; NVS-SM1 hydrochloride. CAS No. 1562338-39-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19620A. | |
| Branebrutinib | Branebrutinib (BMS-986195) is a highly potent, selective covalent, irreversible inhibitor of Brutons tyrosine kinase (BTK), with an IC50 of 0.1 nM[1][2]. Branebrutinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-986195. CAS No. 1912445-55-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112161. | |
| Brassicin | Brassicin, a natural Flavonoid, possesses radical scavenging activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Isorhamnetin 7-O-glucoside. CAS No. 6743-96-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N8193. | |
| Brassinazole | Brassinazole is a selective triazole-type brassinosteroid (BR) biosynthesis inhibitor. Brassinazole is used for regulating plant growth and development[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 280129-83-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-121161A. | |
| Brassinolide | Brassinolide is a predominant plant growth modulator that regulate plant cell elongation. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Brassin lactone. CAS No. 72962-43-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0273. | |
| Brazikumab | Brazikumab (AMG 139) is a human IgG2 monoclonal antibody, selectively binds the p19 subunit of IL-23, with a KD of 0.138 nM for human IL-23. Brazikumab can be used for the research of Crohn's disease[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMG 139; MEDI2070. CAS No. 1610353-18-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99485. | |
| Brazilin | Brazilin is a red dye precursor obtained from the heartwood of several species of tropical hardwoods. Brazilin inhibits the cells proliferation, promotes apoptosis, and induces autophagy through the AMPK/mTOR pathway. Brazilin shows chondroprotective and anti-inflammatory activities[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 474-07-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0072. | |
| BrBzGCp2 | BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC50 of 4.23 μM in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S-p-Bromobenzylglutathione cyclopentyl diester. CAS No. 166038-00-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136684. | |
| BRD0209 | BRD0209 is a potent, selective and dual inhibitor of GSK3α/β inhibitor (GSK3α IC50 = 19 nM; GSK3β IC50 = 5 nM). BRD0209 is also a reversible ATP-competitive inhibitor with fast-off kinetics (Ki = 4.2 nM, respectively). BRD0209 is a tricyclic pyrazolotetrahydroquinolinone compound. BRD0209 has the potential for the research of mood disorder diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1597439-87-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117822. | |
| BRD0539 | BRD0539 is a Streptococcus pyogenes Cas9 (SpCas9) inhibitor with an IC50 of 22 μM in an in vitro DNA cleavage assay[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1403838-79-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136251. | |
| BRD0639 | BRD0639 is a first-in-class inhibitor of the PRMT5-substrate adaptor interaction. BRD0639 is a PRMT5 binding motif (PBM)-competitive agent that can support studies of PBM dependent PRMT5 activities[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2760881-74-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132309. | |
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