MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| C16-PAF | C16-PAF (PAF (C16)), a phospholipid mediator, is a platelet-activating factor and ligand for PAF G-protein-coupled receptor (PAFR). C16-PAF exhibits anti-apoptotic effect and inhibits caspase-dependent death by activating the PAFR. C16-PAF is a potent MAPK and MEK/ERK activator. C16-PAF induces increased vascular permeability[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PAF (C16). CAS No. 74389-68-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108635. |  |
| C16 PEG2000 Ceramide | C16 PEG2000 Ceramide is a polyethylene glycolylated ceramide. C16 PEG2000 Ceramide can be used for lipid carrier to delivery. C16 PEG2000 Ceramide induces autophagy. C16 PEG2000 Ceramide can be used for cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: C16 PEG Ceramide (MW 2000). CAS No. 212116-78-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-144005. | |
| C-176 | C-176 is a selective and blood-brain barrier permeable STING inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 314054-00-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112906. | |
| C-178 | C-178 is a potent and selective covalent inhibitor of STING. C-178 binds to Cys91 and suppresses the STING responses elicited by distinct bona fide activators in mouse but not human[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 329198-87-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-123963. | |
| C18:1-Ceramide | C18:1-Ceramide is a ceramide subspecies. C18:1-Ceramide can be used in the study of type 2 diabetes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 5966-28-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141578. | |
| C188 | C188 (CPD188) is a STAT3 inhibitor with anticancer effects. C188 inhibits STAT3 SH2/pY-peptide binding (IC50 of 20 μM against pY-peptide binding) and IL-6-mediated STAT3 phosphorylation. C188 is selective for STAT3 over STAT1. C188 inhibits nuclear-to-cytoplasmic translocation of Stat3. C188 shows highly active induces apoptosis in breast cancer cell lines with constitutive Stat3 activation (EC50s of 0.73 μM, 3.96 μM, and 7.01 μM in MDA-MB-468, MDA-MB-231, and MDA-MB-435 cultures, respectively)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CPD188. CAS No. 823828-18-8. Pack Sizes: 5 mg. Product ID: HY-112338. | |
| C188-9 | C188-9 (TTI-101) is a STAT3 inhibitor with a Kd value of 4.7 nM. C188-9 targets the SH2 domain of STAT3, blocks the processes of STAT3 ligand binding, receptor recruitment, homodimerization and phosphorylation, and regulates STAT3-mediated genes associated with tumorigenesis and radioresistance. C188-9 regulates STAT1-mediated genes related to radioresistance and reduces the activation level of STAT1. C188-9 downregulates the expression of DNMT1, enhances DAC-induced demethylation and re-expression of RASSF1A, and simultaneously potentiates the anti-tumor effect of DAC on pancreatic cancer cells. C188-9 inhibits both anchorage-dependent and anchorage-independent growth of cancer cells, induces Apoptosis, blocks the growth of tumor xenografts, and suppresses muscle atrophy. C188-9 maintains muscle mass, increases body weight and improves grip strength in tumor-bearing mice. C188-9 can be used in research related to head and neck squamous cell carcinoma, pancreatic cancer, sepsis-related skeletal muscle wasting, non-small cell lung cancer, acute myeloid leukemia and cancer cachexia[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TTI-101. CAS No. 432001-19-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112288. | |
| C18-Ceramide (d18:1/18:0) | C18-Ceramide (d18:1/18:0) is a bioactive molecule with multiple functions in cells, not a traditional agonist or inhibitor targeting a single site. It can act on multiple cellular targets, such as proteins related to endoplasmic reticulum stress (e.g., ATF-4, XBP-1, CHOP), proteins in the PI3K/AKT signaling pathway, and SNARE complex proteins. It exerts activities like inducing cell death, promoting autophagy, and regulating exocytosis through mechanisms such as activating endoplasmic reticulum stress, inhibiting the PI3K/AKT signaling pathway, and affecting lipid raft - related functions. It can be used in research on the mechanism of neuronal injury in the field of neuroscience and in the treatment research of cancers such as glioma in the field of oncology[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: C18-Ceramide. CAS No. 2304-81-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100355. | |
| C18-Ceramide-d7 | C18-Ceramide-d7 is deuterium labeled C18-Ceramide. Uses: Scientific research. Category: Signaling pathways. CAS No. 1840942-14-4. Pack Sizes: 500 μg (1.75 mM * 500 μL in Methanol:Chloroform (10:90)); 1 mg; 5 mg. Product ID: HY-100355S1. | |
| C19 3'-Sulfo galactosylceramide (d18:1/19:0) | C19 3'-Sulfo Galactosylceramide (d18:1/19:0) is a synthetic derivative of sulfatide[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (3'-Sulfo)Galβ-ger(d18:1/19:0); C19 Sulfatide. CAS No. 2692623-78-0. Pack Sizes: 1 mg. Product ID: HY-159251. | |
| C1s-IN-1 trihydrochloride | C1s-IN-1 trihydrochloride (Compound A1) is the selective inhibitor for C1s protease with the Ki of 5.8 μM. C1s-IN-1 trihydrochloride inhibits cleavage of C2 by C1s with an IC50 of 85 μM, inhibits the activation of classic pathway with an IC50 of 22 μM. C1s-IN-1 trihydrochloride is the competitive inhibitor for thrombin with the Ki of 51.2 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1376162-36-5. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg. Product ID: HY-W371165. | |
| C22-Ceramide (d18:1/22:0) | C22-Ceramide (d18:1/22:0) (Cer d18:1/22:0) is an endogenous bioactive sphingolipid. C22-Ceramide (d18:1/22:0) reduces the propensity of C16-ceramide channel formation in isolated rat liver mitochondria and in liposomes[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Behenoyl-D-erythro-sphingosine; C22-Ceramide; Cer d18:1/22:0. CAS No. 27888-44-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-154831. | |
| C24:1-Ceramide | C24:1-Ceramide is one of the most abundant naturally occurring ceramide. Ceramides regulates many diverse biological activities, such as cell apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 54164-50-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-134575. | |
| C24-Ceramide | C24-Ceramide is an orally active competitive binding agonist of PIP4K2C (mTOR complex regulator), thereby activating the mTOR signaling pathway. At the same time, C24-Ceramide changes the membrane morphology by inducing the formation of a partially interlocked gel phase in the phospholipid bilayer. C24-Ceramide can promote the proliferation and migration of keratinocytes to accelerate skin wound healing and drive the proliferation and metastasis of gallbladder cancer cells. The level of C24-Ceramide in serum can be used as a diagnostic marker for gallbladder cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 34435-05-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-134508. | |
| C24-Ceramide (d18:1/24:0) | C24-Ceramide (d18:1/24:0) is a sphingolipid that can be used for the lipid membranes composed. C24-Ceramide (d18:1/24:0) induces time-dependent changes in membrane properties. C24-Ceramide (d18:1/24:0) induces membrane reorganization[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 102917-80-6. Pack Sizes: 1 mg. Product ID: HY-134508A. | |
| C25-140 | C25-140, a first-in-class, orally active, and fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13. C25-140 lowers TRAF6 activity, reduces NF-κB activation, and combats autoimmunity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1358099-18-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120934. | |
| C29 | C29 is a Toll-like receptor 2 (TLR2) inhibitor. C29 blocks hTLR2/1 and hTLR2/6 signaling with IC50s of 19.7 and 37.6 μM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 363600-92-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100461. | |
| C2 Ceramide | C2 Ceramide (Ceramide 2) is the main lipid of the stratum corneum and a protein phosphatase 1 (PP1) activator. C2 Ceramide activates PP2A and ceramide-activated protein phosphatase (CAPP). C2 Ceramide induces cells differentiation, autophagy and apoptosis, inhibits mitochondrial respiratory chain complex III. C2 Ceramide is also a skin conditioning agent that protects the epidermal barrier from water loss[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ceramide 2. CAS No. 3102-57-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101180. | |
| C3a receptor agonist 1 | C3a receptor agonist 1 (compound benzeneacetamide) is a potent C3a receptor agonist. C3a receptor agonist 1 has the potential for the research of acute inflammation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 944997-60-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-128132. | |
| C3 Ceramide | C3 Ceramide is a lipid featuring two hydrophobic tails, one saturated and the other unsaturated. Ceramides may be used in developing lipid nanoparticles or liposomes. Uses: Scientific research. Category: Signaling pathways. CAS No. 362678-52-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W590573. | |
| C3TD879 | C3TD879 is a Type I kinase inhibitor that potently inhibits CITK catalytic activity (IC50 = 12 nM). C3TD879 binds directly to full-length human CITK in cells (NanoBRET Kd < 10 nM). C3TD879 is a chemical probe suitable for interrogating the complex biology of CITK[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2850259-33-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-162266. | |
| C527 | C527 is a is a pan DUB enzyme inhibitor, with a high potency for the USP1/UAF1 complex (IC50=0.88 μM). Uses: Scientific research. Category: Signaling pathways. CAS No. 192718-06-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12988. | |
| C5a Receptor agonist, W5Cha | C5a Receptor agonist, W5Cha (Peptide 1) is a selective complement C5a receptor (C5aR) agonist (EC50=0.2 μM), a hexapeptide derived from the C-terminus of C5a with specific amino acid modifications. C5a Receptor agonist, W5Cha is able to interact with the Arg-206 site of the C5a receptor through its C-terminal arginine, thereby activating the receptor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 144555-23-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5506. | |
| C5 Lenalidomide | C5 Lenalidomide is a 5-amino-substituted Thalidomide (HY-14658) analog. C5 Lenalidomide inhibits LPS (HY-D1056)-stimulated TNF-α production[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Lenalidomide 5'-amine. CAS No. 191732-70-4. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-132248. | |
| C646 | C646 is a selective and competitive histone acetyltransferase p300 inhibitor with Ki of 400 nM, and is less potent for other acetyltransferases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 328968-36-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 20 mg; 50 mg; 100 mg. Product ID: HY-13823. | |
| C6 Ceramide | C6 Ceramide (C6-Cer) is a short-chain, cell-permeable ceramide pathway activator with anticancer activity. C6 Ceramide-mediated miR-29b expression participates in the progression of multiple myeloma through suppressing the proliferation, migration and angiogenesis of endothelial cells by targeting Akt signal pathway. C6 Ceramide exhibits multiple anti-cancer properties including cell cycle arrest, Apoptosis, inhibition of tumor growth and enhances the effects of chemotherapy in drug-resistant cancer cells. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: C6-Cer; N-Hexanoylsphingosine. CAS No. 124753-97-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19542. | |
| C6 NBD Sphingomyelin | C6 NBD Sphingomyelin is a fluorescent short-chain analogue of Sphingomyelin (HY-113498). Chlamydia trachomatis acquires C6 NBD Sphingomyelin endogenously synthesizes from C6-NBD-ceramide and transportes to the chlamydial inclusion. C6 NBD Sphingomyelin can incorporate into the plasma membrane[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 94885-04-8. Pack Sizes: 100 μg; 500 μg; 1 mg. Product ID: HY-D1574. | |
| C75 | C75 is a synthetic fatty-acid synthase (FASN) inhibitor; inhibits prostate cancer cells PC3 with an IC50 of 35 μM[1][2][3]. C75 is a potent CPT1A activator[5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 218137-86-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12364. | |
| C791-0064 | C791-0064 is a RAD52 inhibitor. C791-0064 specifically binds to RAD52 and disrupts its single-strand annealing activity. C791-0064 specifically inhibits the proliferation of cancer cells with BRCA2 deficiency, inducing DNA damage and apoptosis (apoptosis). C791-0064 can be used for the study of BRCA mutation-related cancers (such as breast cancer and ovarian cancer)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 902940-64-1. Pack Sizes: 1 mg. Product ID: HY-153338. | |
| C 87 | C 87 is a novel small-molecule TNFα inhibitor; potently inhibits TNFα-induced cytotoxicity with an IC50 of 8.73 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 332420-90-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100735. | |
| C-8 Ceramide-1-phosphate | C-8 Ceramide-1-phosphate is a cell apoptosis inhibitor and a cell survival inducer that can stimulate DNA synthesis and cell division. C-8 Ceramide-1-phosphate can inhibit acidic sphingomyelinase (SMase) and stimulate PI3-K, which in turn produces PIP3; PIP3 can also inhibit acidic SMase. The C-8 Ceramide-1-phosphate and ceramide can be interconverted in cells through kinase and phosphatase activity, and maintaining the balance between the two is crucial for cellular and tissue homeostasis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 158983-53-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-165099. | |
| CA-074 | CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 134448-10-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103350. | |
| CA-074 methyl ester | CA-074 methyl ester is a specific inhibitor of Cathepsin B, which has potent bioactivities such as neuroprotective, anti-cancer, and anti-inflamatory effects. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CA-074Me. CAS No. 147859-80-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100350. | |
| CA-170 | CA-170 is an orally delivered dual inhibitor of VISTA and PD-L1. CA-170 exhibits potent rescue of proliferation and effector functions of T cells inhibited by PD-L1/L2 and VISTA with selectivity over other immune checkpoint proteins as well as a broad panel of receptors and enzymes[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1673534-76-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101093. | |
| CA-5f | CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. CA-5f increases LC3B-II (a marker to monitor autophagy) and SQSTM1 protein, and also increases ROS production. Anti-tumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1370032-19-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112698. | |
| CA77.1 | CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 is a derivative of AR7 (HY-101106) and can increase the expression of the lysosomal receptor LAMP2A in?lysosomes. CA77.1 improves behavior and neuropathology in PS19 mice model and can be used for alzheimer's?disease research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2412270-22-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134923. | |
| Cabamiquine | Cabamiquine (DDD107498) is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. falciparum 3D7. Cabamiquine inhibits protein synthesis by targeting eEF2/CaMKIII, with an EC50 of 2 nM for WT-PfeEF2[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DDD107498; DDD-498; M5717. CAS No. 1469439-69-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117684. | |
| Cabazitaxel | Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: XRP6258; RPR-116258A; taxoid XRP6258. CAS No. 183133-96-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-15459. | |
| Cabazitaxel-d9 | Cabazitaxel-d9 is deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: XRP6258-d9; RPR-116258A-d9; taxoid XRP6258-d9. CAS No. 1383572-19-7. Pack Sizes: 1 mg. Product ID: HY-15459S1. | |
| Cabergoline | Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively). Uses: Scientific research. Category: Signaling pathways. Alternative Names: FCE-21336. CAS No. 81409-90-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15296. | |
| Cabergoline (Standard) | Cabergoline (Standard) is the analytical standard of Cabergoline. This product is intended for research and analytical applications. Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively). Uses: Scientific research. Category: Signaling pathways. Alternative Names: FCE-21336 (Standard). CAS No. 81409-90-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15296R. | |
| Cabiralizumab | Cabiralizumab (FPA 008) is an anti-CSF1R monoclonal antibody (MAb). Cabiralizumab enhances T cell infiltration and antitumor T cell immune responses. Cabiralizumab inhibits the activation of osteoclasts and blocks bone destruction, and can be used in the research of rheumatoid arthritis (RA). Cabiralizumab can combine with Nivolumab (HY-P9903) for lung cancer research[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FPA 008; Anti-Human CSF1R Recombinant Antibody. CAS No. 1613144-80-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99259. | |
| Cabotamig | Cabotamig is a humanized bispecific T-cell engager antibody targeting CDH17/CD3. Cabotamig is generated from anti-CDH17 monoclonal ARB102 by linking a CD3-binding scFv in the format of IgG4-scFv. Cabotamig can be used for the research of cancer, such as gastric cancer and colon cancers[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ARB202. CAS No. 2755301-09-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990730. | |
| Cabotegravir | Cabotegravir (GSK-1265744) is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC50 values of 2.5 nM, 0.41 μM and 0.81 μM for HIVADA, OAT3 and OAT1, respectively. Cabotegravir is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir can be used to research AIDS[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSK-1265744; S/GSK1265744. CAS No. 1051375-10-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15592. | |
| Cabozantinib | Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: XL184; BMS-907351. CAS No. 849217-68-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13016. | |
| Cabozantinib-d6 | Cabozantinib-d6 is the deuterium labeled Cabozantinib. Cabozantinib is a potent multiple receptor tyrosine kinases (RTKs) inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: XL184-d6; BMS-907351-d6. CAS No. 1802168-46-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13016S. | |
| Cabozantinib S-malate | Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: XL184 S-malate; BMS-907351 S-malate. CAS No. 1140909-48-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-12044. | |
| Cabozantinib (Standard) | Cabozantinib (Standard) is the analytical standard of Cabozantinib. This product is intended for research and analytical applications. Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: XL184 (Standard); BMS-907351 (Standard). CAS No. 849217-68-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13016R. | |
| CaCCinh-A01 | CaCCinh-A01 is an inhibitor of both TMEM16A and calcium-activated chloride channel (CaCC) with IC50s of 2.1 and 10 μM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 407587-33-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100611. | |
| Cadazolid | Cadazolid (ACT-179811) is a new oxazolidinone antibiotic with potent activity against Clostridium difficile. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ACT-179811. CAS No. 1025097-10-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100436. | |
| CADD522 | CADD522 is a RUNX2-DNA binding inhibitor (downregulates RUNX2-mediated transcription of downstream target genes), with an IC50 of 10 nM. CADD522 inhibits primary tumor growth and experimental metastasis of tumor cells in the lungs of immune-compromised mice. CADD522 can be used in study of cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 199735-88-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107999. | |
| Cadefrecitinib | Cadefrecitinib (GLPG3667) is a reversible, ATP-competitive and orally active TYK2 inhibitor with an IC50 of 2.3 nM. Cadefrecitinib inhibits IFNα/pSTAT1, and the IC50 values ??in human peripheral blood mononuclear cell (PBMC) and whole blood assays are 70 nM and 623 nM, respectively. Cadefrecitinib has the potential for the study of inflammatory and autoimmune diseases[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GLPG3667. CAS No. 2308520-97-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156961. | |
| Cadonilimab | Cadonilimab (AK104) is a humanized tetravalent IgG1 bispecific antibody targeting PD1/CTLA4. Cadonilimab blocks both PD-1 and CTLA-4 pathways, thereby relieving their corresponding immunosuppressive effects and reversing tumor specific T cell exhaustion. Cadonilimab significantly downregulates Fc-mediated effector functions, including antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), complement dependent cytotoxicity (CDC). Cadonilimab can be used for research of metastatic cervical cancer, as well as other malignancies such as gastric cancer, GEJ adenocarcinoma and non-small cell lung cancer (NSCLC)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AK104. CAS No. 2394841-59-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99117. | |
| Caerulein | Caerulein is a decapeptide and a potent cholecystokinin receptor agonist. Caerulein is a safe and effective cholecystokinetic agent with a direct spasmogenic effect on the gallbladder muscle and bile ducts[1]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: Ceruletide; Cerulein; FI-6934. CAS No. 17650-98-5. Pack Sizes: 100 μg; 500 μg; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0190. | |
| Caerulomycin A | Caerulomycin A is an orally active immunomodulator and antimicrobial agent. Caerulomycin A targets Smad3, STAT1 and GATA-3. Caerulomycin A downregulates GATA-3 expression, inhibits Th2 cell differentiation and Th2 cytokine production, reduces IgE levels, and alleviates pulmonary inflammatory responses and eosinophil infiltration. Caerulomycin A ameliorates collagen-induced arthritis symptoms, reduces joint inflammation and synovitis, and decreases the levels of proinflammatory cytokines in joints. Caerulomycin A inhibits the growth of some filamentous fungi, yeasts and specific bacteria. Caerulomycin A can be used in research related to arthritis and asthma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cerulomycin; Caerulomycin. CAS No. 21802-37-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114495. | |
| Caf1-IN-1 | Caf1-IN-1 (Compound 8j) is inhibitor for ribonuclease Caf1 with an IC50 of 0.59 μM. Caf1-IN-1 is also a weak inhibitor for poly(A)-specific ribonuclease (PARN) with IC50 of 23.9 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1807775-88-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-158970. | |
| Cafelkibart | HY-P990908 is an CCR8-targeting IgG1κ type chimeric antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LM-108. CAS No. 2851855-89-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P990908. | |
| Cafestol | Cafestol is an orally active diterpenoid and an inhibitor of ERK2. Cafestol has elevated blood lipids, anti-inflammatory, anti-angiogenic and anti-diabetic activities. In addition, Cafestol induces tumor cell apoptosis and autophagy, which can be used in the study of cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 469-83-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N6257. | |
| Caffeic acid | Caffeic acid is an inhibitor of both TRPV1 ion channel and 5-Lipoxygenase (5-LO). Uses: Scientific research. Category: Signaling pathways. CAS No. 331-39-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g; 25 g. Product ID: HY-N0172. | |
| Caffeic acid phenethyl ester | Caffeic acid phenethyl ester is a NF-κB inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 104594-70-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 100 mg; 500 mg; 1 g. Product ID: HY-N0274. | |
| Caffeine orange | Caffeine orange (Compound 1) is an aqueous-phase fluorescence turn-on sensor for caffeine that is highly selective to caffeine. Caffeine orange makes caffeinated coffee appear orange when exposed to 532 nM of green excitation light. Caffeine orange has excellent photophysical properties such as high extinction coefficient, high light stability and narrow emission bandwidth, which can be used in the research of caffeine detection devices[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1632296-13-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D2264. | |
| Caffeoyltryptophan | Caffeoyltryptophan is a competitive PTP1B inhibitor, with an IC50 of 16.99 μM. Caffeoyltryptophan can also inhibit α-glucosidase, linoleic acid peroxidation and haemolysis. Caffeoyltryptophan can be used for the research of type 2 diabetes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 109163-69-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N10002. | |
| Caficrestat | Caficrestat (AT-001) is an orally active aldose reductase inhibitor. Caficrestat can be used in the study of diabetic cardiomyopathy[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AT-001; Aldose reductase-IN-1. CAS No. 1355612-71-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-18967. | |
| Caftaric acid | Caftaric acid (trans-Caftaric acid) is a polyphenolic antidiuretic, antioxidant and anti-apoptotic agent that can be hydrolyzed by intestinal microbial esterases. Caftaric acid exerts its antioxidant and potential anti-inflammatory effects mainly through intestinal microbial metabolism. Caftaric acid can reduce renal damage, restore electrolyte balance, renal function indicators and antioxidant enzyme activities in a rat albinism model, and further exert anti-oxidative stress and anti-inflammatory activities[1][2][3]. Uses: Scientific research. Category: Natural products. Alternative Names: trans-Caftaric acid. CAS No. 67879-58-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-N0321. | |
| Cagrilintide | Cagrilintide is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant weight loss and reduces food intake. Cagrilintide has the potential for the research of obesity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1415456-99-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3462. | |
| CA inhibitor 1 | CA inhibitor 1 (GS-6207 analog) is a potent HIV capsid inhibitor for HIV inhibition[1]. CA inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GS-6207 analog. CAS No. 2189684-45-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-124594. | |
| Cajanin | Cajanin is a potent and orally active anti-melanogenic agent. Cajanin shows antiproliferative activity in MNT1 Cells. Cajanin efficiently decreases the melanin content. Cajanin down-regulates the mRNA and protein expression levels of MITF, tyrosinase, TRP-1 and Dct (TRP-2). Cajanin induces cell cycle arrest at G2/M and S phase. Cajanin stimulates osteoblast proliferation. Cajanin has the potential for the research of human hyperpigmented disorders and menopausal osteoporosis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 32884-36-9. Pack Sizes: 1 mg. Product ID: HY-N2983. | |
| Calcein | Calcein is a fluorescent dye and self-quenching probe, used as an indicator of lipid vesicle leakage, and also as a complexometric indicator for titration of calcium ions with EDTA, and for fluorometric determination of calcium. Calcein cannot directly cross the intact cell membrane of a living cell, unlike Calcein-AM (HY-D0041) which is cell-permeable. Calcein can also be used as a model drug for evaluating efficiency and bioavailability of drug delivery systems[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Fluorexon. CAS No. 1461-15-0. Pack Sizes: 100 mg. Product ID: HY-D0040. | |
| Calcein-AM | Calcein AM, has cell membrane permeability and can easily enter the cell. Calcein AM has no fluorescence and is hydrolyzed by endogenous esterase in the cell to produce polar molecule Calcein (Calcein), which has strong negative charge and cannot permeate the cell membrane. Calcein can emit strong green fluorescence, so it is often used with Propidium Iodide for cell viability/virulence detection, excitation/emission wavelength: 494/515 nm[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Calcein acetoxymethyl ester. CAS No. 148504-34-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-D0041. | |
| Calcein-AM (solution) | Calcein AM (solution) , has cell membrane permeability and can easily enter the cell. Calcein AM has no fluorescence and is hydrolyzed by endogenous esterase in the cell to produce polar molecule Calcein (Calcein) , which has strong negative charge and cannot permeate the cell membrane. Calcein can emit strong green fluorescence, so it is often used with Propidium Iodide for cell viability/virulence detection, excitation/emission wavelength: 494/515 nm[1].Solvent and concentration: DMSO: 2 mM. Uses: Scientific research. Category: Signaling pathways. CAS No. 148504-34-1. Pack Sizes: 50 μL; 100 μL. Product ID: HY-DY1036. | |
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