BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| AS 1842856 | AS 1842856 is a potent and selective inhibitor of Forkhead box protein O1 transcription factor (FoxO1; IC50 = 33 nM). AS 1842856 reduces glucose production in dose manner via the inhibition of glucose-6 phosphatase and phosphoenolpyruvate carboxykinase mRNA levels in a rat hepatic cell line. AS 1842856 is promisingly to be a therapy of type 2 diabetes mellitus and obesity. Uses: Potential treatment of type 2 diabetes mellitus and obesity. Alternative Names: AS1842856; AS-1842856; AS 1842856. 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid. Grades: 98%. CAS No. 836620-48-5. Molecular formula: C18H22FN3O3. Mole weight: 347.38. |  |
| AS-604850 | AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 250 nM, over 80-fold selectivity for PI3Kγ than PI3Kδ/β, and 18-fold more selective for PI3Kγ than PI3Kα. Alternative Names: AS604850; AS 604850; AS-604850. PI3K gamma inhibitor; PI 3-Kgamma Inhibitor II; (5E)-5-[(2,2-Difluoro-1,3-benzodioxol-5-YL)methylene]-1,3-thiazolidine-2,4-dione. Grades: 98%. CAS No. 648449-76-7. Molecular formula: C11H5F2NO4S. Mole weight: 285.211. | |
| AS 8351 | AS 8351 has been found to show the activity in inducing reprogramming of human fetal lung fibroblasts into functional cardiomyocytes. Alternative Names: AS-8351; AS-8351; AS-8351; 2-Hydroxy-1-naphthaldehyde isonicotinoylhydrazone. Grades: ≥98% by HPLC. CAS No. 796-42-9. Molecular formula: C17H13N3O2. Mole weight: 291.30. | |
| Asciminib-[15N,d4] | Asciminib-[15N,d4] is the labelled analogue of Asciminib. Asciminib, also known as ABL-001, is a potent and selective allosteric Bcr-Abl inhibitor. Asciminib inhibits Ba/F3 cell growth with an IC50 of 0.25 nM. Alternative Names: [15N,2H4]-Asciminib; (R)-N-(4-(Chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)-5-(1H-pyrazol-3-yl)nicotinamide[15N,2H4]. Molecular formula: C20H14D4ClF2N4[15N]O3. Mole weight: 454.86. | |
| Asimadoline | Asimadoline is a κ opioid receptor agonist with less brain-penetrant ability. Asimadoline is the potential treatment of irritable bowel syndrome. Alternative Names: N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methyl-2,2-diphenylacetamide. CAS No. 153205-46-0. Molecular formula: C27H30N2O2. Mole weight: 414.549. | |
| ASP-9521 | ASP9521 is a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3). ASP9521 has demonstrated anti-tumour activity in in vitro and in vivo preclinical models. ASP9521 inhibited conversion of androstenedione (AD) into testosterone (T) by recombinant human or cynomolgus monkey AKR1C3 in a concentration-dependent manner. Alternative Names: ASP9521; ASP-9521; ASP 9521. AKR1C3 inhibitor ; 17HSD5 inhibitor;4-(2-Hydroxy-2-methylpropyl)piperidino(5-methoxy-1H-indole-2-yl)methanone; 1-[1-[(5-Methoxy-1H-indol-2-yl)carbonyl]piperidin-4-yl]-2-methylpropan-2-ol. Grades: 98%. CAS No. 1126084-37-4. Molecular formula: C19H26N2O3. Mole weight: 330.428. | |
| Asperulosidic acid | Asperulosidic acid is a naturally occurring compound abundant in diverse plants, garnering immense interest due to its remarkable pharmacological activities. Its anti-inflammatory and antioxidant attributes have propelled its prominence in the biomedical research. Alternative Names: ASPA; (1S,4aS,5S,7aS)-7-[(acetyloxy)methyl]-1-(beta-D-glucopyranosyloxy)-5-hydroxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid. Grades: 98%. CAS No. 25368-11-0. Molecular formula: C18H24O12. Mole weight: 432.38. | |
| Astragaloside | Astragaloside is extracted from roots of Astragalus membranaceus (Fisch.) Bunge. It is traditionally prescribed for the prevention and treatment of cerebrovascular diseases. Astragaloside is a natural compound used in cosmetics material. Alternative Names: astragaloside; 17429-69-5; Isorhamnetin 3-gentiobioside; 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one4H-1-Benzopyran-4-one, 3-((6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-. Grades: >98%. CAS No. 17429-69-5. Molecular formula: C28H32O17. Mole weight: 640.5. | |
| Astressin 2B TFA | Astressin 2B TFA is a selective and potent corticotropin-releasing factor receptor 2 (CRF2) antagonist with IC50 values of > 500 nM and 1.3 for CRF1 and CRF2 respectively. It antagonizes CRF2-mediated inhibition of gastric emptying. Grades: 98%. Molecular formula: C183H307N49O53.xC2HF3O2. Mole weight: 4041.69 (free base). | |
| Asunaprevir | Asunaprevir is a potent hepatitis C virus (HCV) non-structural protein protease inhibitor currently in Phase III clinical trials for the treatment of HCV infection. Uses: Protease inhibitors. Alternative Names: BMS-650032; BMS 650032; BMS650032; Asunaprevir. brand name: Sunvepra. Grades: >98%. CAS No. 630420-16-5. Molecular formula: C35H46ClN5O9S. Mole weight: 748.29. | |
| AT13148 | AT13148 is an orally available multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity. It can block phosphorylation of AKT, p70S6K, PKA, ROCK and SGK substrates, and induce apoptosis in cancer cells. Alternative Names: AT-13148; (1S)-2-amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol. Grades: >98%. CAS No. 1056901-62-2. Molecular formula: C17H16ClN3O. Mole weight: 313.78. | |
| AT-406 | AT-406 is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3 (with Ki of 66.4 nM), cIAP1-BIR3(with Ki of 1.9 nM) and cIAP2-BIR3 (with Ki of 5.1 nM), respectively. Alternative Names: AT406; AT 406; SM-406; SM 406; SM406; ARRY-334543; ARRY 334543; ARRY334543. Grades: >98%. CAS No. 1071992-99-8. Molecular formula: C32H43N5O4. Mole weight: 561.71. | |
| AT7519 HCl | AT-7519 is an orally bioavailable small molecule CDK inhibitor with potential antineoplastic activity. AT7519M selectively binds to and inhibits cyclin dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation. Alternative Names: AT7519 HCl; AT 7519 HCl; AT-7519 HCl. CAS No. 902135-91-5. Molecular formula: C16H18Cl3N5O2. Mole weight: 418.71. | |
| AT9283 | AT-9283 is a broad spectrum kinase inhibitor that potently inhibits Aurora A, Aurora B, JAK2, JAK3, and c-ABL (IC50= 3, 3, 1.2, 1.1, and 4 nM, respectively). It also potently (IC50 = <1 μM) inhibits serine / threonine kinases as well as receptor and non-receptor tyrosine kinases. Alternative Names: AT9283; AT 9283; AT-9283. Grades:>98%. CAS No. 896466-04-9. Molecular formula: C19H23N7O2. Mole weight: 381.43. | |
| Atazanavir | Atazanavir is a novel and potent azapeptide protease inhibitor that specifically inhibits the human immunodeficiency virus type 1 (HIV-1) protease enzyme with inhibition constant Ki of 66 nmol/L and also inhibits the viral replication of HIV-1 with 50% effective concentration EC50 ranging from 2.6 to 5.3 nmol/L. Atazanavir binds to HIV-1 protease preventing the cleavage of gag and gag-pol polyproteins, which results in the formation of immature virions in HIV-1-infected cells. Atazanavir has a different C-2 symmetric chemical structure and a generally greater antiretroviral potency in various HIV strains compared to other protease inhibitors, including indinavir, nelfinavir, ritonavir, saquinavir and amprenavir. Alternative Names: Atazanavir ; Reyataz ; Atazanavir sulfate ; CGP75136 ; CGP75176 ; CGP75355 ; BMS232632 ; CGP 73547 ; CGP 75136 ; CGP 75176 ; CGP 75355 ; CGP-73547 ; CGP-75136 ; CGP-75176 ; CGP-75355 ; BMS 232632 ; BMS-232632 ; BMS-232632-05 ; C413408. Grades: 0.98. CAS No. 198904-31-3. Molecular formula: C38H52N6O7. Mole weight: 704.869. | |
| ATB 346 | ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity. CAS No. 1226895-20-0. Molecular formula: C21H19NO3S. Mole weight: 365.447. | |
| Atorvastatin 3-Deoxyhept-2E-Enoic Acid (Calcium Salt) | An impurity of Atorvastatin, a statin medication used to treat cardiovascular disease. Alternative Names: (2E)-2,3-Dehydroxy Atorvastatin calcium; (2E,5S)-7-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-2-heptenoic Acid calcium salt. Grades: > 95%. Molecular formula: C66H64F2N4O8Ca. Mole weight: 1119.33. | |
| Atorvastatin Cyclic (Fluorophenyl) Sodium Salt Impurity | An impurity of Atorvastatin, a statin medication used to treat cardiovascular disease. Alternative Names: ATV-FX1 sodium salt. CAS No. 1315629-79-8. Molecular formula: C33H34FN2NaO7. Mole weight: 612.62. | |
| Atorvastatin Methyl Ester | Atorvastatin Methyl Ester is an impurity of Atorvastatin, which is an HMG-CoA reductase inhibitor used to reduce cholesterol and prevent cardiovascular-related disease. Alternative Names: (βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid Methyl Ester; (3R,5R)-Methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbaMoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate; 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, methyl ester, (βR,δR)-; Methyl (βR,δR)-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoate. Grades: ≥95%. CAS No. 345891-62-5. Molecular formula: C34H37FN2O5. Mole weight: 572.68. | |
| Atorvastatin N-(3,5-Dihydroxy-7-heptanoic Acid)amide | Atorvastatin N-(3,5-Dihydroxy-7-heptanoic Acid)amide is a prominent compound in the research of dyslipidemia and associated cardiovascular disorders. Its efficacious mechanism of action lies in its tremendous capacity to inhibit HMG-CoA reductase, a pivotal enzyme profoundly engaged in the intricate process of cholesterol biosynthesis. Uses: Atorvastatin (a791750) impurity. Alternative Names: (3R,5R)-7-[[(3R,5R)-7-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3,5-dihydroxy-1-oxoheptyl]amino]-3,5-dihydroxy-heptanoic Acid Calcium Salt. Grades: 95%. CAS No. 1105067-87-5. Molecular formula: C40H48FN3O8?0.5Ca. Mole weight: 736.86. | |
| Atractylenolide I | Atractylenolide I is a sesquiterpenoid found in the rhizome of Atractylodes macrocephala. Atractylenolide I ameliorates sepsis syndrome by reduction of pro-inflammatory cytokines and LPS, and provides an improvement in liver and kidney functions. Uses: Anti-inflammatory. Alternative Names: ATRACTYLENOLIDE-1; (4aS,8aS)-4a,5,6,7,8,8a-Hexahydro-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one; 3,8aβ-Dimethyl-5-methylene-2,4,4aα,5,6,7,8,8a-octahydronaphtho[2,3-b]furan-2-one; Eudesma-4(15),7(11),8-trien-12-olide; 8,9-Dehydroasterolide. Grades: >98%. CAS No. 73069-13-3. Molecular formula: C15H18O2. Mole weight: 230.3. | |
| Atracurium Besylate EP impurity B (Oxalate Salt) | Atracurium Besylate EP impurity B (Oxalate Salt) is an impurity of Atracurium Besylate, a neuromuscular blocking agent used during surgeries and for mechanical ventilation. Alternative Names: (R)-Pentane-1,5-diyl bis(3-((R)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)propanoate) dioxalate; CisAtracurium Oxalate; Atracurium Besylate EP impurity B (Oxalate Salt); (1R,1'R)-2,2'-(3,11-Dioxo-4,10-dioxatridecamethylene)-bis-(1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratrylisoquindline)-dioxalate; Atracurium dioxalate; 5-[3-[(1R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]propanoyloxy]pentyl 3-[(1R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]propanoate; oxalic acid; cis-Atracurium oxalate; SCHEMBL8949609; WDA68752; MFCD11973631; BS-50869; CS-0186139; F15234; Q-101019; (R)-Pentane-1,5-diylbis(3-((R)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)propanoate)dioxalate. Grades: 95%. CAS No. 96687-52-4. Molecular formula: C55H70N2O20. Mole weight: 1079.15000. | |
| (±)-Atropine-[d3] (N-methyl-[d3]) | One of the isotopic labelled form of (±)-Atropine, which could be used as a pesticide poisoning and as a muscle relaxant. Alternative Names: (±)-Atropine-d3 (N-methyl-d3). Grades: 95% by HPLC; 98% atom D. CAS No. 1276197-36-4. Molecular formula: C17H20D3NO. Mole weight: 292.39. | |
| ATTO 488 carboxylic acid | ATTO 488 is a rhodamine-based fluorescent label. ATTO 488 carboxylic acid is a carboxylic acid derivative of ATTO 488, which can be used to label proteins or antibodies. Molecular formula: C25H23N3O10S2. Mole weight: 589.59. | |
| ATTO 647N Chloride | ATTO 647N Chloride. | |
| AtuFECT01 | AtuFect01 is part of the lipid system AtuPLEX and shows more effective siRNA binding activity and delivery to vascular endothelial cells. Alternative Names: β-Alaninamide, L-arginyl-2-amino-N-hexadecyl-N-(9Z)-9-octadecenyl-, trihydrochloride, (2S)-; β-Alaninamide, L-arginyl-2-amino-N-hexadecyl-N-(9Z)-9-octadecen-1-yl-, hydrochloride (1:3), (2S)-; (S)-2-amino-N-((S)-2-amino-3-(hexadecyl((Z)-octadec-9-en-1-yl)amino)-3-oxopropyl)-5-guanidinopentanamide trihydrochloride. Grades: ≥95%. CAS No. 869094-19-9. Molecular formula: C43H87N7O2.3HCl. Mole weight: 843.58. | |
| Auriculasin | Auriculasin is a flavonoid derivative isolated from the herbs of Derris robusta. Alternative Names: Cudraisoflavone A. Grades: 96%. CAS No. 60297-37-2. Molecular formula: C25H24O6. Mole weight: 420.5. | |
| Auristatin E | Auristatin E is a synthetic analog of dolastatin 10. Auristatin E is a highly potent antimitotic agent.Auristatin E inhibits tubulin polymerization. Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity. Uses: Adcs cytotoxin. Alternative Names: Auristatin E. Grades: ≥96.0% (HPLC). CAS No. 160800-57-7. Molecular formula: C40H69N5O7. Mole weight: 732.01. | |
| AV-412 | AV-412 is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may suppress tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization. Alternative Names: AV 412; AV412; N-[4-(3-chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide. CAS No. 451492-95-8. Molecular formula: C27H28ClFN6O. Mole weight: 507.01. | |
| Avagacestat | BMS-708163 is a potent and orally bioavailable inhibitor of γ-secretase that more potently inhibits the cleavage of APP (IC50 = 0.30 nM) to Aβ40 than signaling through Notch (IC50s = 58 nM). Uses: Gamma secretase inhibitors and modulators. Alternative Names: Avagacestat; BMS 708163; (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide. Grades: >98%. CAS No. 1146699-66-2. Molecular formula: C20H17ClF4N4O4S. Mole weight: 520.89. | |
| Avicularin | Avicularin, a natural plant flavonoid isolated from the herbs of Polygonum aviculare, exhibits anti-inflammatory activity through the suppression of ERK signaling pathway in LPS-stimulated RAW 264.7 macrophage cells. By decreasing C/EBPα-activated GLUT4-mediated glucose uptake in adipocytes and potently inhibiting fatty acid synthase, avicularin can inhibit the accumulation of the intracellular lipids. Uses: Anti-inflammatory. Alternative Names: Fenicularin; Quercetin 3-alpha-L-arabinofuranoside; Avicularoside. Grades: >98%. CAS No. 572-30-5. Molecular formula: C20H18O11. Mole weight: 434.4. | |
| AVL-292 | AVL-292, also known as CC-292, is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, AVL-292 targets and covalently binds to BTK, thereby preventing its activity. Uses: Protein kinase inhibitors. Alternative Names: CC-292; CC292; CC 292; AVL292; AVL 292; spebrutinib. Grades: 98%. CAS No. 1202757-89-8. Molecular formula: C22H22FN5O3. Mole weight: 423.44. | |
| AWD 131-138 | AWD 131-138 is a partial agonist of GABAA receptor with low affinity for the benzodiazepine binding site. AWD 131-138 exhibits potent anticonvulsant and anxiolytic properties in rodent models. It is used as an antiepileptic drug for the treatment of canine idiopathic epilepsy. Alternative Names: AWD 131-138; AWD-131-138; AWD131-138; AWD 131138; Imepitoin; 3-(4-chlorophenyl)-5-morpholin-4-yl-4H-imidazol-2-one. CAS No. 188116-07-6. Molecular formula: C13H14ClN3O2. Mole weight: 279.724. | |
| Axinysone A | Axinysone A is a natural compound used in the research of cancer. Derived from natural sources, this product acts as a valuable inhibitor of specific signaling pathways involved in tumor growth and progression. Alternative Names: (-)-Axinysone A. Grades: 97.5%. CAS No. 1114491-57-4. Molecular formula: C15H22O2. Mole weight: 234.338. | |
| Ayanin | Ayanin isolated from the rhizomes of Curcuma aromatica. Alternative Names: QUERCETIN 3,7,4'-TRIMETHYL ETHER;AYANIN;2-(3-Hydroxy-4-methoxyphenyl)-3,7-dimethoxy-5-hydroxy-4H-1-benzopyran-4-one;3',5-Dihydroxy-3,4',7-trimethoxyflavone; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,7-dimethoxychromen-4-one. Grades: 0.985. CAS No. 572-32-7. Molecular formula: C18H16O7. Mole weight: 344.3. | |
| AZ7371 | AZ7371 is a novel non-covalent inhibitor of decaprenylphosphoryl-D-ribose oxidase (DprE1) with IC50 of 10 nM. Alternative Names: AZ-7371; AZ 7371; TBA-7371; DprE1-IN-1. Grades: 98%. CAS No. 1494675-86-3. Molecular formula: C18H21N5O3. Mole weight: 355.40. | |
| AZ-960 | AZ-960 is an ATP-competitive inhibitor of JAK2 with Ki value of 0.45 nM. It inhibits proliferation in a SET-2 human megakaryoblastic cell line harboring the JAK2V617F mutation with GI50 value of 33 nM. Alternative Names: (S)-5-Fluoro-2-((1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)nicotinonitrile; 3-Pyridinecarbonitrile, 5-fluoro-2-(((1S)-1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)-; 5-Fluoro-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-6-[(5-methyl-1H-pyrazol-3-yl)amino]nicotinonitrile. Grades: >98%. CAS No. 905586-69-8. Molecular formula: C18H16F2N6. Mole weight: 354.36. | |
| Aza-BODIPY | Aza-BODIPY. CAS No. 1195110-34-9. | |
| Azadirachtin H | Azadirachtin H is a naturally occurring metabolite isolated from A. indica. Alternative Names: 11Alpha-Azadirachtin H. Grades: 95%. CAS No. 124788-15-1. Molecular formula: C33H42O14. Mole weight: 662.68. | |
| AZD0364 | AZD-0364 is a potent and selective ERK2 inhibitor, which has an IC50 value of 0.6 nM. AZD-0364 is measured in the A375 phospho-p90RSK assays with IC50s of 5.7 nM. AZD-0364 can inhibit the growth of a panel of cancer cell lines. The combination of Selumetinib and AZD-0364 ethanesulfonic acid results in a reduction in tumor growth. Alternative Names: AZD-0364; AZD 0364; tizaterkib. Grades: ≥98%. CAS No. 2097416-76-5. Molecular formula: C24H24F2N8O2. Mole weight: 494.50. | |
| AZD1981 | AZD1981, as a potent antagonist in a disease relevant cell system, inhibits DK-PGD2-induced CD11b expression in human eosinophils with IC50 of 10 nM. Alternative Names: AZD1981; AZD 1981; AZD-1981. Grades: 98%. CAS No. 802904-66-1. Molecular formula: C19H17ClN2O3S. Mole weight: 388.866. | |
| AZD3759 | AZD3759 is a n orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, AZD3759 binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. Alternative Names: AZD3759; AZD-3759; AZD 3759. Grades: 98%. CAS No. 1626387-80-1. Molecular formula: C22H23ClFN5O3. Mole weight: 459.91. | |
| AZD-4635 | AZD-4635 is an orally available adenosine 2A receptor (A2AR) inhibitor. Alternative Names: AZD-4635; AZD 4635; AZD4635; HTL-1071; HTL 1071; HTL1071; 6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine. CAS No. 1321514-06-0. Molecular formula: C15H11ClFN5. Mole weight: 315.736. | |
| AZD-5069 | AZD-5069 is a potent and selective CXCR2 antagonist with the potential to inhibit neutrophil migration into the airways in patients with COPD. AZD-5069 was shown to inhibit binding of radiolabeled CXCL8 to human CXCR2 with a pIC50 value of 9.1. Alternative Names: AZD-5069; AZD 5069; AZD5069. Grades: 98%. CAS No. 878385-84-3. Molecular formula: C18H22F2N4O5S2. Mole weight: 476.51. | |
| AZD 5153 | AZD5153 is a potent, selective, and orally available inhibitor of the bromodomain and extraterminal (BET). It can simultaneously bind two bromodomains in BRD4 with the IC50 value of 5 nM, which has been shown to increase antitumor activity in multiple xenograft models of acute myeloid leukemia, multiple myeloma, and diffuse large B cell lymphoma. AZD5153 also shows enhanced potency as a result of bivalent binding and a clear correlation between BRD4 activity and cellular potency. Alternative Names: AZD-5153; AZD5153; (R)-4-(2-(4-(1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)-1,3-dimethylpiperazin-2-one. Grades: 98%. CAS No. 1869912-39-9. Molecular formula: C25H33N7O3. Mole weight: 479.57. | |
| AZD6738 | AZD6738 is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM. Phase 1/2. Alternative Names: AZD-6738; AZD 6738. Grades: 98%. CAS No. 1352226-88-0. Molecular formula: C20H24N6O2S. Mole weight: 412.51. | |
| AZD-7594 | AZD-7594 is an inhaled selective glucocorticoid receptor (GCCR) modulator. Alternative Names: AZD-7594; AZD 7594; AZD7594; AZ13189620; AZ-13189620; AZ 13189620; 3-[5-[(1R,2S)-2-(2,2-difluoropropanoylamino)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)propoxy]indazol-1-yl]-N-[(3R)-oxolan-3-yl]benzamide. CAS No. 1196509-60-0. Molecular formula: C32H32F2N4O6. Mole weight: 606.627. | |
| AZD8186 | AZD 8186 is a selective PI3Kβ/δ inhibitor (IC50= 0.003 μM for PI3Kβ, and 0.017 μM for PI3Kδ) with potential antineoplastic activity. It shows no significant binding against a panel of 442 other kinases when tested at a concentration of 10 μM and exhibits high oral efficacy in mouse cancer models. Alternative Names: (R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide; AZD8186; AZD 8186; AZD-8186. CAS No. 1627494-13-6. Molecular formula: C24H25F2N3O4. Mole weight: 457.4. | |
| AZD-8931 | Sapitinib, also known as AZD-8931, is an erbB receptor tyrosine kinase inhibitor with potential antineoplastic activity. AZD8931 binds to and inhibits erbB tyrosine receptor kinases, which may result in the inhibition of cellular proliferation and angiogenesis in tumors expressing erbB. Alternative Names: AZD8931; AZD 8931; Momelotinib; Sapitinib. Grades: 0.98. CAS No. 848942-61-0. Molecular formula: C23H25ClFN5O3. Mole weight: 473.933. | |
| AZD-9291 mesylate | AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. It inhibits both activating and resistant EGFR mutations while sparing the normal form of EGFR that is present in normal skin and gut cells, thereby reducing the side effects encountered with currently available medicines. Alternative Names: Mereletinib mesylate; EGFR inhibitor; AZD9291 mesylate; AZD 9291 mesylate. Grades: >98%. CAS No. 1421373-66-1. Molecular formula: C29H37N7O5S. Mole weight: 595.71. | |
| Azelastine HCl | Azelastine HCl is a potent, second-generation, selective, histamine antagonist. It inhibits histamine via competing with histamine for the H1 receptor. Uses: Histamine antagonist. Alternative Names: ZELASTINE HYDROCHLORIDE; AC1Q1SYE; HYDROGEN AZELASTINE CHLORIDE; AKOS026749829; DR002552. Grades: >98%. CAS No. 79307-93-0. Molecular formula: C22H25Cl2N3O. Mole weight: 418.36. | |
| Azeliragon | Azeliragon is a potent and orally active RAGE inhibitor as a potential treatment for patients with mild-to-moderate Alzheimer's disease (AD). Uses: A potent and orally active rage inhibitor. Alternative Names: TTP488; PF04494700; TTP 488; PF0 4494700; TTP-488; PF-044947003-[4-[2-Butyl-1-[4-(4-chlorophenoxy)phenyl]-1H-imidazol-4-yl]phenoxy]-N,N-diethyl-1-propanamine. Grades: ≥98%. CAS No. 603148-36-3. Molecular formula: C32H38ClN3O2. Mole weight: 532.124. | |
| Azido-PEG2-NHS ester | Azido-PEG2-NHS ester is a non-cleavable 2-unit PEG linker that can be used to synthesize antibody-conjugated drugs (ADCs). Alternative Names: Azido-PEG2-CH2CO2-NHS; N3-PEG2-C2-NHS ester; Propanoic acid, 3-[2-(2-azidoethoxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester; N3-PEG2-CH2CH2COONHS Ester; Azido-PEG2-NHS; N3-PEG2-SPA; 1-({3-[2-(2-Azidoethoxy)ethoxy]propanoyl}oxy)-2,5-pyrrolidinedione; 2,5-Pyrrolidinedione, 1-[3-[2-(2-azidoethoxy)ethoxy]-1-oxopropoxy]-; 2,5-Dioxo-1-pyrrolidinyl 3-[2-(2-azidoethoxy)ethoxy]propanoate; N-Succinimido 9-azido-4,7-dioxanonanoate. Grades: ≥98%. CAS No. 1312309-64-0. Molecular formula: C11H16N4O6. Mole weight: 300.27. | |
| Azido-PEG3-acetic acid | N3-PEG3-CH2COOH is a PROTAC linker, which refers to the alkyl / ether composition. N3-PEG3-CH2COOH can be used in the synthesis of a series of PROTACs. N3-PEG3-CH2COOH is a PEG derivative containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. Alternative Names: Azido-PEG3-CH2CO2H;11-Azido-3,6,9-trioxaundecanoic Acid; N3-PEG3-CH2COOH; {2-[2-(2-Azidoethoxy)ethoxy]ethoxy}acetic acid; Acetic acid, 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-; Azido-PEG3-CH2COOH. Grades: 95%. CAS No. 172531-37-2. Molecular formula: C8H15N3O5. Mole weight: 233.22. | |
| Azilsartan-[d5] | Azilsartan-[d5] is the labelled analogue of Azilsartan, which is an angiotensin II type 1 receptor antagonist and could be used against hypertension and inflammation. Alternative Names: Azilsartan D5; 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-(ethoxy-d5)-1H-benzimidazole-7-carboxylic Acid; 2-(Ethoxy-d5)-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic Acid; TAK 536-d5; Azilsartan O-Ethyl-d5. Grades: ≥98% by HPLC; ≥99% atom D. CAS No. 1346599-45-8. Molecular formula: C25H15D5N4O5. Mole weight: 461.48. | |
| Azilsartan medoxomil | Azilsartan Medoxomil is a potent angiotensin II type 1 (AT1) receptor antagonist that inhibits the RAAS, with an IC50 of 2.6 nM. It exhibits more than 10,000-fold selectivity over AT2. Azilsartan Medoxomil can be used for the treatment of mild to moderate essential hypertension. Uses: The treatment of mild to moderate essential hypertension. Alternative Names: TAK-491 Medoxomil; TAK491 Medoxomil; Edarbi; 863031-21-4; Azilsartan (medoxomil); TAK 491; UNII-LL0G25K7I2. Grades: >98%. CAS No. 863031-21-4. Molecular formula: C30H24N4O8. Mole weight: 568.53. | |
| Azithromycin Aglycone | Azithromycin Aglycone is an impurity of Azithromycin. Azithromycin is a macrolide antibiotic used to treat a variety of bacterial infections. Alternative Names: 1-Oxa-6-azacyclopentadecan-15-one, 2-ethyl-3,4,10,11,13-pentahydroxy-3,5,6,8,10,12,14-heptamethyl-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-. Grades: 98%. CAS No. 117693-42-2. Molecular formula: C22H43NO7. Mole weight: 433.58. | |
| Azithromycin EP Impurity G | Azithromycin EP Impurity G is an impurity found in the macrolide antibiotic, azithromycin. It can be used as a standard to trace azithromycin impurities. Alternative Names: 3'-N-Demethyl-3'-N-((4-methylphenyl)sulfonyl)azithromycin; 3'-N-Demethyl-3'-N-[(4-methylphenyl)sulfonyl]azithromycin. Grades: > 95%. CAS No. 612069-31-5. Molecular formula: C44H76N2O14S. Mole weight: 889.17. | |
| Azithromycin EP Impurity I | Azithromycin EP Impurity I is an impurity of azithromycin, a macrolide antibiotic used for bacterial infections. Alternative Names: CP-64434; Azithromycin Impurity I; N'-Desmethyl Azithromycin; 3'-N-Desmethylazithromycin; N-Demethylazithromycin. Grades: > 95%. CAS No. 172617-84-4. Molecular formula: C37H70N2O12. Mole weight: 734.98. | |
| Azithromycin EP Impurity J | Azithromycin EP Impurity J is a metabolite of the semi-synthetic macrolide antibiotic Azithromycin. Alternative Names: CP 66458; Desosaminylazithromycin; (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10,13-tetrahydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one; 1-Oxa-6-azacyclopentadecan-15-one, 2-ethyl-3,4,10,13-tetrahydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, [2R-(2R*,3S*,4R*,5R*,8R*,10R*,11R*,12S*,13S*,14R*)]-; Decladinosylazithromycin; Descladinose azithromycin. Grades: >95%. CAS No. 117693-41-1. Molecular formula: C30H58N2O9. Mole weight: 590.79. | |
| Azithromycin EP Impurity Q | An impurity of Azithromycin, a macrolide antibiotic effective against bacterial infections. Alternative Names: Azithromycin Impurity Q; 3'-N-Didesmethyl-3'-N-tosyl azithromycin; 3'-N-{[4-(Acetylamino)phenyl]sulfonyl}-3',3'-didemethyl Azithromycin. Grades: > 95%. CAS No. 2095879-65-3. Molecular formula: C44H75N3O15S. Mole weight: 918.15. | |
| Aztreonam impurity D | Aztreonam impurity D is an impurity of Aztreonam. Aztreonam is a monobactam antibiotic used primarily to treat gram-negative bacterial infections. Uses: Aztreonam (a965200). Alternative Names: Desulfo Aztreonam; Aztreonam Desulfated Impurity; Aztreonam USP Impurity D. Grades: 95%. CAS No. 102579-59-9. Molecular formula: C13H17N5O5S. Mole weight: 355.37. | |
| Aztreonam impurity F | Aztreonam Ethyl Ester is used in the HPLC reversed stationary phase for aztreonam and precursors. Aztreonam is a monobactam antibiotic used primarily to treat gram-negative bacterial infections. Alternative Names: Aztreonam USP Impurity F; Aztreonam Ethyl Ester. Grades: 95%. CAS No. 102579-57-7. Molecular formula: C15H21N5O8S2. Mole weight: 463.48. | |
| Azvudine | Azvudine is a nucleoside reverse transcriptase inhibitor (NRTI), which exhibits inhibtory effects on HIV, HBV and HCV. Alternative Names: 4'-C-Azido-2'-deoxy-2'-fluoro-b-D-arabinocytidine; 4'-Azido-2'-deoxy-2'-fluoroaracytidine; RO-0622; 4-amino-1-((2R,3S,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one; 2'-deoxy-2'-β-fluoro-4'-azidocytidine; 1-(4'-azido-2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)cytosine. Grades: ≥95%. CAS No. 1011529-10-4. Molecular formula: C9H11FN6O4. Mole weight: 286.22. | |
| Baccatin IX | Baccatin IX is extracted from the leaves and twigs of Taxus yunnanensis. Alternative Names: 9-Dihydro-14-hydroxybaccatin III. CAS No. 1623410-12-7. Molecular formula: C31H40O12. Mole weight: 604.64. | |
| Baccatin VIII | Baccatin VIII is extracted from the leaves and twigs of Taxus yunnanensis. It inhibits MCF-7 and HL-60 with IC50 values of 9.67 and 3.44 uM respectively. Alternative Names: 9-Dihydro-14-hydroxy-13-O-acetylbaccatin III. Grades: 97.5%. CAS No. 1623410-10-5. Molecular formula: C33H42O13. Mole weight: 646.68. | |
| Bacitracin B2 Acetate Salt | Bacitracin B2 Acetate Salt. | |
| Bacoside A3 | Bacoside A is a mixture of chemical compounds, known as bacosides, isolated from Bacopa monnieri. Bacoside A3 is a triterpenoid saponin first isolated from B. monniera, which acts as a potential anticancer compound. Alternative Names: Bacopa Pgp. Grades: ≥98%. CAS No. 157408-08-7. Molecular formula: C47H76O18. Mole weight: 929.1. | |
| Bactenecin trifluoroacetate | Bactenecin is a cyclic cationic peptide with antibacterial activity. Alternative Names: L-arginyl-L-leucyl-L-cysteinyl-L-arginyl-L-isoleucyl-L-valyl-L-valyl-L-isoleucyl-L-arginyl-L-valyl-L-cysteinyl-L-arginine, cyclic (3→11)-disulfide, trifluoroacetate salt. Grades: 98%. Molecular formula: C65H119F3N24O15S2. Mole weight: 1597.94. | |
| (+)-Balanophonin | (+)-Balanophonin is a lignan isolated from the barks of Gmelina arborea and the seeds of Crataegus pinnatifida. Study indicates that (+)-Balanophonin inhibits the proliferation of OPM2 and RPMI-8226 cells. Alternative Names: (2E)-3-[(2S,3R)-2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-5-benzofuranyl]-2-propenal. Grades: >98%. CAS No. 215319-47-4. Molecular formula: C20H20O6. Mole weight: 356.37. | |
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