BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Baloxavir-[d4] | Baloxavir-[d4] is an isotope compound of Baloxavir. Baloxavir marboxil is a first-in-class, one-dose oral medicine with a novel proposed mechanism of action that has demonstrated efficacy in a wide range of influenza viruses, including in vitro activity against oseltamivir-resistant strains and avian strains (H7N9, H5N1) in non-clinical studies. Baloxavir is a polymerase acidic, cap-dependent, endonuclease inhibitor that is indicated for the treatment of acute uncomplicated influenza in patients aged 12 years and older who have been symptomatic for no more than 48 hours. It blocks viral proliferation by binding to one of two endonuclease binding sites, inhibiting the initiation of mRNA synthesis for both influenza A and influenza B strains. Baloxavir can interact with polyvalent cation-containing products, which can decrease its plasma concentration. CAS No. 2415027-80-2. Molecular formula: C24H15D4F2N3O4S. Mole weight: 487.51. |  |
| Baloxavir marboxil | Baloxavir marboxil is a first-in-class, one-dose oral medicine with a novel proposed mechanism of action that has demonstrated efficacy in a wide range of influenza viruses, including in vitro activity against oseltamivir-resistant strains and avian strains (H7N9, H5N1) in non-clinical studies. Baloxavir is a polymerase acidic, cap-dependent, endonuclease inhibitor that is indicated for the treatment of acute uncomplicated influenza in patients aged 12 years and older who have been symptomatic for no more than 48 hours. It blocks viral proliferation by binding to one of two endonuclease binding sites, inhibiting the initiation of mRNA synthesis for both influenza A and influenza B strains. Baloxavir can interact with polyvalent cation-containing products, which can decrease its plasma concentration. Alternative Names: S-033188; HY-109025. Grades: ≥98%. CAS No. 1985606-14-1. Molecular formula: C27H23F2N3O7S. Mole weight: 571.55. | |
| Baohuoside II | IKarisoside A is a natural compound isolated from Epimedium koreanum, which has anti-inflammatory properties. Uses: Cardioprotective effect. Alternative Names: Icarisoside A. Grades: >98%. CAS No. 55395-07-8. Molecular formula: C26H28O10. Mole weight: 500.49. | |
| Baohuoside V | Baohuoside V is extracted from the herbs of Epimedium brevicornum Maxim. Alternative Names: 3-[[6-Deoxy-2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-mannopyranosyl]oxy]-7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one; Diphylloside B. Grades: >98%. CAS No. 118544-18-6. Molecular formula: C38H48O19. Mole weight: 808.8. | |
| BAR-501 | BAR-501, a UDCA derivative, is a selective GPBAR1 agonist devoid of any FXR agonistic activity. BAR-501 effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1, with a EC50 of 1 μM. Besides, it protects against development of portal hypertension in rodent models of liver injury and endothelial dysfunction. Alternative Names: 3R,5S,6S,7S,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((R)-5-hydroxypentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol; BAR-501; BAR 501; BAR501. CAS No. 1632118-69-4. Molecular formula: C26H46O3. Mole weight: 406.651. | |
| Baricitinib phosphate | Baricitinib, also known as INCB028050 or LY3009104, is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK2 (5.7 nM). Baricitinib has been approved by FDA for the treatment of rheumatoid arthritis (RA). Alternative Names: INCB 028050; LY 3009104; INCB028050; LY3009104; LY-3009104; INCB-028050. Grades: >98%. CAS No. 1187595-84-1. Molecular formula: C16H20N7O6PS. Mole weight: 469.41. | |
| Barnidipine-[d5] | Barnidipine-[d5] is a stable isotope form of Barnidipine which is a calcium channel blocker. Alternative Names: 3-(3S)-1-[(D5)benzyl]pyrrolidin-3-yl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; (S)-3-((S)-1-Benzylpyrrolidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate-d5. Molecular formula: C27H24D5N3O6. Mole weight: 496.57. | |
| Basmisanil | Basmisanil is a highly selective inverse agonist / negative allosteric modulator GABAAα5 receptors. It was developed by Roche to treat cognitive impairment associated with Down syndrome. In Apr 2016, Roche completed the phase II in Down syndrome (In adolescents, In adults) in USA, Argentina, Canada, France, Italy, Mexico, New Zealand, Singapore, Spain and the UK. In Sep 2016, Phase-II clinical trials in Neurological disorders (In adults, In the elderly) in Spain was on going. Uses: Down syndrome; neurological disorders. Alternative Names: (1,1-dioxidothiomorpholino)(6-((3-(4-fluorophenyl)-5-methylisoxazol-4-yl)methoxy)pyridin-3-yl)methanone; RG 1662; RG-1662; RG1662; RO5186582; RO-5186582; RO 5186582. Grades: 98%. CAS No. 1159600-41-5. Molecular formula: C21H20FN3O5S. Mole weight: 445.47. | |
| Batabulin sodium | Batabulin sodium is a synthetic pentafluorophenylsulfonamide with potential antineoplastic activity. T138067 covalently binds to and selectively modifies the beta 1, beta 2, beta 3, and beta 4 isotypes of beta tubulin at a conserved cysteine residue, resulting in disruption of microtubule polymerization, collapse of the cytoskeleton. Alternative Names: T138067 sodium; T138067-sodium; T 138067 sodium; T 67; D03059; D 03059; D-03059; T-138067 sodium. CAS No. 195533-53-0. Molecular formula: C13H7F6NO3S. Mole weight: 371.253. | |
| Batefenterol Succinate | Batefenterol is a beta 2 adrenergic receptor agonist and also a muscarinic receptor antagonist. It shows high affinity for hM2 (Ki = 1.4 nM), hM3 muscarinic receptors (Ki = 1.3 nM) and hβ2-adrenoceptors (Ki = 3.7 nM). Batefenterol is a hβ2-adrenoceptor agonist with EC50 value of 0.29 nM for stimulation of cAMP levels. This is 440- and 320-fold functional selectivity over hβ1- and hβ3-adrenoceptors. Alternative Names: Batefenterol Succinate; 945905-37-3; UNII-552KVF22JT; Batefenterol succinate [USAN]552KVF22JT. CAS No. 945905-37-3. Molecular formula: C44H48ClN5O11. Mole weight: 858.3. | |
| Bavachin | Bavachin, a natural phytoestrogen found in the fruits of Psoralea corylifolia L, potentially protects cartilage from inflammation-mediated damage in joints of osteoarthritis patients through decreasing IL-1β-induced activation of IKK-IκBα-NF-κB signaling pathway. Bavachin also exhibits the activities of antioxidant, antimutagenic and weak phytoestrogen by binding and activating the estrogen receptor. Alternative Names: 4H-1-benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten -1-yl)-;7-Hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-en-1-yl)-2,3-dihydro-4H-chromen -4-one. Grades: >98%. CAS No. 19879-32-4. Molecular formula: C20H20O4. Mole weight: 324.4. | |
| Bavachinin | Bavachinin is a natural compound isolated from the Chinese herb Fructus Psoraleae. Bavachinin has potent anti-angiogenic activity in vitro and in vivo. Bavachinin inhibited increases in HIF-1α activity in human KB carcinoma (HeLa cell derivative) and human HOS osteosarcoma cells under hypoxia in a concentration-dependent manner, probably by enhancing the interaction between von Hippel-Lindau (VHL) and HIF-1α. It significantly inhibited Th2 cytokine production, including IL-4, IL-5 and IL-13. Notably, this compound almost completely blocked inflammation in the ovalbumin (OVA)-sensitized animal asthma model. Uses: Antiinflammatory; antipyretic; analgesic. Alternative Names: 7-O-Methylbavachin; Bavachinin A. Grades: >98%. CAS No. 19879-30-2. Molecular formula: C21H22O4. Mole weight: 338.4. | |
| BAY-1895344 | BAY-1895344 is a selective ATR (ataxia-telangiectasia and Rad3 related protein) inhibitor that inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 = 78 nM). BAY-1895344 is developed for the treatment of patients with advanced solid tumors and lymphomas, and it is undergoing a phase I clinical trial of safety and tolerability for cancer patients. Uses: A selective atr (ataxia-telangiectasia and rad3 related protein) inhibitor used for the treatment of advanced solid tumors and lymphomas. Alternative Names: BAY-1895344; BAY 1895344; BAY1895344; (R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine. Grades: ≥98 %. CAS No. 1876467-74-1. Molecular formula: C20H21N7O. Mole weight: 375.181. | |
| BAY-218 | BAY-218, which is known as BAY-2335218, is a potent and selective small-molecule AhR inhibitor with an IC50 of 39.9 nM in human cell line. It is a new modality to counteract tumor immunosuppression. Alternative Names: BAY 218; BAY218; BAY-2335218; BAY 2335218; BAY2335218; (S)-6-(4-chlorophenyl)-2-(3-fluorophenyl)-N-(1-hydroxypropan-2-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide; AHR antagonist 1. Grades: 98%. CAS No. 2162982-11-6. Molecular formula: C20H17ClFN3O3. Mole weight: 401.82. | |
| BAY 299 | BAY 299 is a potent and selective inhibitor of BRD1 and TAF1 (IC50 = 6-67 and 8-13 nM, respectively) with selectivity over other bromodomains (>30-fold over other members of the BRPF family; BRD9 and ATAD2; >300-fold over BRD4). BAY 299 suppresses binding of BRD1 and TAF1 to histone H4 (IC50 = 575 nM and 0.9 μM, respectively) and histone H3.3 (IC50 = 825 nM and 1.4 μM, respectively). Alternative Names: BAY-299; BAY 299; BAY299. 6-(3-Hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione. Grades: ≥98% by HPLC. CAS No. 2080306-23-4. Molecular formula: C25H23N3O4. Mole weight: 429.47. | |
| BAY 41-4109 | BAY 41-4109 is a novel drug inhibiting hepatitis B virus capsid formation and replication. Alternative Names: BAY-41-4109; BAY41-4109; BAY 41-4109; BAY-414109; BAY414109; BAY 414109. methyl (4R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate. Grades: >98%. CAS No. 298708-81-3. Molecular formula: C18H13ClF3N3O2. Mole weight: 395.766. | |
| BAY-57-1293 | BAY 57-1293 represents a new class of potent inhibitors of herpes simplex virus (HSV) that target the virus helicase primase complex. Potent helicase-primase inhibitor (HPI) effective against herpes simplex virus (HSV) infections with IC50 value of 20 nM for inhibition of the replication of both HSV-1 and HSV-2 in Vero cells, and ED50 value of 0.5 mg/kg for both HSV-1 and HSV-2 in the murine lethal challenge model of disseminated herpes. Uses: For research used only. Alternative Names: Pritelivir; BAY-57-1293; BAY 57-1293; BAY-57 1293; BAY 57 1293; BAY571293; AIC316; AIC 316; AIC-316. Grades: 98%. CAS No. 348086-71-5. Molecular formula: C18H18N4O3S2. Mole weight: 402.49. | |
| BAY-876 | BAY-876 is a potent and selective inhibitor of GLUT1, which is overexpressed in multiple cancers. Uses: Anticancer agent. Alternative Names: BAY-876; BAY 876; BAY876. 4-N-[1-[(4-cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)pyrazol-4-yl]-7-fluoroquinoline-2,4-dicarboxamide. Grades: 95%. CAS No. 1799753-84-6. Molecular formula: C24H16F4N6O2. Mole weight: 496.426. | |
| BAY-985 | BAY-985 is a highly effective, orally active and selective TANK-binding kinase 1 (TBK1) and IκB kinase ε dual inhibitor, with anti-tumor activity. Alternative Names: BAY985; GTPL10597; EX-A3294. Grades: ≥98% by HPLC. CAS No. 2409479-29-2. Molecular formula: C27H30F3N9O. Mole weight: 553.6. | |
| (±)-Bay K 8644 | (±)-Bay K 8644 is a L-type Ca2+ channel activator. It exhibits positive inotropic, vasoconstrictive and behavioral effects in vivo. Uses: Reprogramming. Alternative Names: Bay K 8644; (+/-)-BAY K 8644; BAY-K-8644; methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate. Grades: 98%. CAS No. 71145-03-4. Molecular formula: C16H15F3N2O4. Mole weight: 356.3. | |
| BCN-PEG4-NHS ester | BCN-endo-PEG4-NHS is an ADC Linker containing 4 PEG units. Alternative Names: BCN-endo-PEG4-NHS; BCN-endo-PEG4-SPA; BCN-exo-PEG4-NHS; rel-2,5-Dioxopyrrolidin-1-yl 1-((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azanonadecan-19-oate. Grades: ≥98%. CAS No. 1702356-19-1. Molecular formula: C26H38N2O10. Mole weight: 538.59. | |
| BD 1047 dihydrobromide | The dihydrobromide salt form of BD-1047, a selective σ1 receptor antagonist, has been found to have antipsychotic effect and could be probably used against schizophrenia and neuropathic pain. Uses: Bd 1047 dihydrobromide is a selective antagonist of σ receptors. Alternative Names: BD-1047 (dihydrobromide); BD-1047 dihydrobromide; N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide. Grades: 98%. CAS No. 138356-21-5. Molecular formula: C13H22Br2Cl2N2. Mole weight: 437.04. | |
| BD140 [for Albumin binding assay] | BD140 [for Albumin binding assay]. Alternative Names: 2,2-difluoro-6-methyl-4-[(E)-2-(4-propoxyphenyl)ethenyl]-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaene; 4,4-Difluoro-1-methyl-3-(4-propoxystyryl)-4-bora-3a,4a-diaza-s-indacene; (E)-5,5-Difluoro-1-methyl-3-(4-propoxystyryl)-5H-5l4,6l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine. Grades: >98.0% by GC. CAS No. 1201643-08-4. Molecular formula: C21H21BF2N2O. Mole weight: 366.22. | |
| BDA-366 | BDA-366 is a small-molecule antagonist of Bcl2-BH4 domain with high affinity and selectivity for Bcl2-BH4. BDA-366 induces apoptosis in multiple myeloma cells via Bcl2 conformational change. Alternative Names: BDA-366; BDA 366; BDA366; 1-[[(2S)-3-(diethylamino)-2-hydroxypropyl]amino]-4-[[(2S)-oxiran-2-yl]methylamino]anthracene-9,10-dione. Grades: >98%. CAS No. 1909226-00-1. Molecular formula: C24H29N3O4. Mole weight: 423.513. | |
| BEC HCl | BEC HCl is an Arginase II inhibitor(Ki=0.31μM).In vitro,BEC HCl enhances NO-dependent smooth muscle relaxation by binding to arginase as a transition state analogue.In vivo,BEC HCl enhances peribronchiolar and perivascular inflammation in mice. Alternative Names: (2R)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid hydrochloride. Grades: 98%. CAS No. 222638-67-7. Molecular formula: C5H13BClNO4S. Mole weight: 229.482. | |
| Bedaquiline fumarate | Bedaquiline fumarate is an anti-tuberculosis drug which selectively inhibits the mycobacterial energy metabolism and found to be effective against all states of Mycobacterium tuberculosis. It possesses a unique mechanism of action that disrupts the activity of the mycobacterial adenosine triphosphate synthase. It has an excellent in vitro activity against Mycobacterium tuberculosis, including multidrug resistant M tuberculosis, however, its side effect profile limits its use against MDR-TB when no other effective regimen can be provided. Uses: Antitubercular agents. Alternative Names: (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-ol fumarate. Grades: >98%. CAS No. 845533-86-0. Molecular formula: C36H35BrN2O6. Mole weight: 671.58. | |
| Beinaglutide TFA | Beinaglutide TFA. | |
| Belinostat | Belinostat is a hydroxamic acid-type histone deacetylase (HDAC) inhibitor. Belinostat targets HDAC enzymes to inhibit tumor cell proliferation and angiogenesis, induce apoptosis and promote cellular differentiation. Uses: Antineoplastic agents. Alternative Names: Belinostat; PXD 101; Beleodaq; PDX101; PX 105684; PXD-101; PXD101; (E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide. CAS No. 414864-00-9. Molecular formula: C15H14N2O4S. Mole weight: 318.347. | |
| Bellidifolin | Bellidifolin is a xanthone that can be isolated from the plants of Gentiana species. Study shows that bellidifolin is a potent hypoglycemic agent in streptozotocin (STZ)-induced diabetic rats from Swertia japonica. Bellidifolin may contribute to the protective effects associated with nerve injury initiated by hypoxia by mechanisms related to inhibition of cell apoptosis independent of the ERK pathway, but may involve blockade of p38MAPK signaling pathway activation and downstream caspase-3 expression. Alternative Names: 1,5,8-Trihydroxy-3-methoxy-9H-xanthen-9-one. Grades: 98.5%. CAS No. 2798-25-6. Molecular formula: C14H10O6. Mole weight: 274.228. | |
| Belnacasan | Belnacasan is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM. Belnacasan inhibits interlukin-1β biosynthesis. Alternative Names: VX 765, VX765, VX-765, Belnacasan; (2S)-1-[(2S)-2-[(4-amino-3-chlorobenzoyl)amino]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide. Grades: ≥98%. CAS No. 273404-37-8. Molecular formula: C24H33ClN4O6. Mole weight: 509. | |
| Benazeprilat | Benazeprilat is the active metabolite of benazepril, formed after cleavage of the ester group. It is a potent inhibitor of angiotensin-converting enzyme (ACE). Alternative Names: Benazepril Related Compound C; Benazepril USP Related Compound C; Benazepril Diacid; (3S)-3-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic Acid. Grades: 95%. CAS No. 86541-78-8. Molecular formula: C22H24N2O5. Mole weight: 396.45. | |
| Benazepril EP Impurity G | Benazepril EP Impurity G is an ethyl ester derivative of Benazepril, which is an angiotensin-converting enzyme (ACE) inhibitor used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Alternative Names: Benazepril Related Compound G; Benazepril USP Related Compound G; Benazepril ethyl ester; (S)-Ethyl 2-(((S)-1-(2-ethoxy-2-oxoethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)amino)-4-phenylbutanoate; (3-(1-Ethoxycarbonyl-3-phenyl-(1S)-propyl)amino-2,3,4,5-tetrahydro-2-oxo-1H-1-(3S)-benzazepine)-1-acetic Acid ethyl Ester. Grades: 95%. CAS No. 103129-58-4. Molecular formula: C26H32N2O5. Mole weight: 452.54. | |
| Bendamustine Chloro Dimer Impurity | Bendamustine Chloro Dimer Impurity is an impurity of Bendamustine, a chemotherapy medication indicated for the treatment of chronic lymphocytic leukemia, multiple myeloma, and non-Hodgkin's lymphoma. Alternative Names: Bendamustine Dimer Impurity; 5-[bis(2-Chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic Acid 2-[[2-(3-Carboxypropyl)-1-methyl-1H-benzimidazol-5-yl](2-chloroethyl)amino]ethyl Ester. Grades: > 95%. CAS No. 1228551-91-4. Molecular formula: C32H41Cl3N6O4. Mole weight: 680.08. | |
| Bendamustine-[d8] | A labelled analogue of Bendamustine. Bendamustine is a chemotherapy medication used in the treatment of chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin's lymphoma. Alternative Names: 5-[Bis(2-chloroethyl-1,1,2,2-d4)amino]-1-methyl-1H-benzimidazole-2-butanoic acid; 4-(5-(Bis(2-chloroethyl-1,1,2,2-d4)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid; Bendamustine D8; Bendamustine-d8; ω-[1-Methyl-5-[bis(β-chloroethyl-d4)amino]-2-benzimidazolyl]butyric acid. Grades: 96%. CAS No. 1134803-33-0. Molecular formula: C16H13Cl2D8N3O2. Mole weight: 366.31. | |
| Benidipine hydrochloride | Benidipine hydrochloride is the hydrochloride salt form of Benidipine, which is a dihydropyridine calcium channel blocker for the treatment of high blood pressure (hypertension). Alternative Names: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester, hydrochloride (1:1), (4R)-rel-; Coniel; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (4R)-rel-; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (R*,R*)-(±)-; (±)-Benidipine hydrochloride; KW 3049; KW-3049; KW3049; rac Benidipine Hydrochloride. Grades: >98%. CAS No. 91599-74-5. Molecular formula: C28H31N3O6.HCl. Mole weight: 542.02. | |
| Benzamide, N-[4-methyl-3-[[4-(6-methyl-3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]- | This product is a kinase inhibitor used in the treatment of certain types of cancer, including non-small cell lung cancer and pancreatic cancer. It works by inhibiting specific enzymes involved in cell growth and proliferation, ultimately leading to tumor regression. Alternative Names: N-[4-methyl-3-[[4-(6-methylpyridin-3-yl)pyrimidin-2-yl]amino]phenyl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide; CHEMBL1079113; 1032314-85-4; SCHEMBL11939618; BDBM50313640; ZINC49018631. Grades: 95%. CAS No. 1032314-85-4. Molecular formula: C30H33N7O. Mole weight: 507.63. | |
| Benzamil | Benzamil is a Na+/Ca2+ exchanger (NCX) inhibitor and epithelial sodium channel (ENaC) blocker. Benzamil has been developed as a promising treatment for cystic fibrosis. Alternative Names: Benzylamiloride. CAS No. 2898-76-2. Molecular formula: C13H14ClN7O. Mole weight: 319.75. | |
| Benzamil hydrochloride | Benzamil hydrochloride is a Na+/Ca2+ exhanger (NCX) inhibitor (IC50 ~ 100 nM) and an epithelial sodium channel (ENaC) blocker. Benzamil is an analogue of amiloride, and it is potentially used for the treatment of cystic fibrosis. Uses: Potential treatment of cystic fibrosis. Alternative Names: N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 161804-20-2. Molecular formula: C13H14ClN7O.HCl. Mole weight: 356.21. | |
| (Benzene-1,3,5-triyl)triacetonitrile | (Benzene-1,3,5-triyl)triacetonitrile (CAS# 80935-59-7 ) is a useful research chemical. Alternative Names: 1,3,5-Benzenetriacetonitrile; 1,3,5-Benzenetrisacetonitrile. Grades: 98%. CAS No. 80935-59-7. Molecular formula: C12H9N3. Mole weight: 195.22. | |
| Benzetimide hydrochloride | Benzetimide hydrochloride is a muscarinic acetylcholine receptor antagonist that has anticholinergic properties and could block pilocarpine-induced lacrimation. Uses: Amuscarinic acetylcholine receptor antagonist. Alternative Names: R 4929; R4929; R-4929Spasmentral;3-(1-benzylpiperidin-4-yl)-3-phenylpiperidine-2,6-dione;hydrochloride. Grades: ≥98%. CAS No. 5633-14-7. Molecular formula: C23H26N2O2.HCl. Mole weight: 398.93. | |
| Benzoic acid, 2-(3-methyl-1-oxobutyl)- | Benzoic acid, 2-(3-methyl-1-oxobutyl)- is an impurity of Butylphthalide, an anti-cerebral-ischemia drug. Alternative Names: 2-(3-methylbutanoyl)benzoic acid. CAS No. 152567-80-1. Molecular formula: C12H14O3. Mole weight: 206.241. | |
| (-)-Benzotetramisole | (-)-Benzotetramisole is a chiral thiourea catalyst that has emerged as an efficient class of organocatalysts due to their unique dual hydrogen-bonding capacity. Alternative Names: (-)-BTM. Grades: >98.0%(GC). CAS No. 950194-37-3. Molecular formula: C15H12N2S. Mole weight: 252.33. | |
| Benzoylhypacoitine | Benzoylhypacoitine is extracted from the roots of Aconitum carmichaeli Debx. It might be the principal active components which affect mitochondrial growth by Fuzi and its processed products. Uses: Might be the principal active components which affect mitochondrial growth by fuzi and its processed products. Alternative Names: Benzoylhypaconine; Deacetylhypaconitine. Grades: >98%. CAS No. 63238-66-4. Molecular formula: C31H43NO9. Mole weight: 573.68. | |
| Benzoylmesaconine | Benzoylmesaconine is the most abundant component of Wutou decoction, which is widely used in China because of its therapeutic effect on rheumatoid arthritis. Alternative Names: Mesaconine 14-benzoate. Grades: >98%. CAS No. 63238-67-5. Molecular formula: C31H43NO10. Mole weight: 589.67. | |
| Benzoylmesaconine-7-Palmitate | Benzoylmesaconine-7-Palmitate is an alkaloid isolated from aconitum carmichaeli Debx. Benzoylmesaconine has powerful antinociceptive, antiarrhythmic and properties due to their ability to blockade voltage-dependent sodium channels, but has less toxic monoesters than aconitine and mesaconitine. Grades: > 98%. Molecular formula: C47H73NO11. Mole weight: 828.08. | |
| Benzthiazuron-[d3] | Benzthiazuron-[d3] is a deuterium labelled Benzthiazuron, an herbicide used to control annual broad-leaved weeds in a variety of crops. Alternative Names: Benzthiazuron-d3. Molecular formula: C9H6D3N3OS. Mole weight: 210.27. | |
| Benzyl 3,5-bis(phenylmethoxy)benzoate | An impurity of Terbutaline, which is a β-Adrenergic receptor agonist and could be used as a bronchodilator agent. Alternative Names: enzoic acid, 3,5-bis(phenylmethoxy)-, phenylmethyl ester; 3,5-Dibenzyloxybenzoic acid, benzyl ester. CAS No. 50513-72-9. Molecular formula: C28H24O4. Mole weight: 424.496. | |
| Benzyl (4-hydroxyphenyl)carbamate | Benzyl (4-hydroxyphenyl)carbamate, a crucial pharmaceutical intermediate, synergizes diverse drug synthesis. Capable of potentiating anti-neoplastic responses in conjunction with antioxidant activities, this molecular entity encapsulates immense therapeutic potential. Notably, investigations are underway to examine its efficacy as a prospective therapeutic agent for neurodegenerative conditions including Alzheimer's and Parkinson's diseases. Alternative Names: 4-(benzyloxycarbonylamino)phenol; (4-hydroxy-phenyl)-carbamic acid benzyl ester. CAS No. 7107-59-7. Molecular formula: C14H13NO3. Mole weight: 243.26. | |
| Bepotastine Besylate | Bepotastine is a histamine H1 receptor antagonist. Bepotastine has been approved in Japan for the treatment of allergic rhinitis and uriticaria / puritus. Alternative Names: Bepotastine besylate; Bepreve; Betotastine besilate; Talion; 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-1-piperidinebutanoic acid, monobenzenesulfonate. Grades: >98%. CAS No. 190786-44-8. Molecular formula: C27H31ClN2O6S. Mole weight: 547.063. | |
| Beraprost | Beraprost is a synthetic analogue of prostacyclin, under clinical trials for the treatment of pulmonary hypertension. Beraprost acts by binding to prostacyclin membrane receptors ultimately inhibiting the release of Ca2+ from intracellular storage sites. Beraprost sodium (beraprost) is a stable, orally active prostacyclin analogue with vasodilatory, antiplatelet and cytoprotective effects. Alternative Names: Procylin; Careload; Dorner; Beraprost sodium; TRK-100; TRK 100; TRK100; YM-533; YM533; YM 533; ML-1129; ML 1129; ML1129; MDL 201229; MDL-201229; MDL201229. CAS No. 88430-50-6. Molecular formula: C24H30O5. Mole weight: 398.49. | |
| Berberrubine | Berberrubine comes from the herbs of Coptis chinensis Franch. Berberrubine dose-dependently inhibited IL-8 and MCP-1 protein levels in the media and mRNA expression of the cells stimulated with IL-1beta or TNF-alpha. Uses: Antitumor / anti-diabetic. Alternative Names: 5,6-Dihydro-9-hydroxy-10-methoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium chloride; 9-Berberoline chloride; 9-Demethoxy-9-hydroxyberberinium chloride; Berberrubine chloride; Beroline chloride; Chileninone; Nerberrubine. Grades: >98%. CAS No. 15401-69-1. Molecular formula: C19H16ClNO4. Mole weight: 357.79. | |
| Besifloxacin Hydrochloride | Besifloxacin HCl is a fourth-generation fluoroquinolone antibiotic that has a broad spectrum in vitro activity against a wide range of Gram-positive and Gram-negative ocular pathogens. Uses: For research used only. Alternative Names: Besifloxacin hydrochloride; Besifloxacin HCl; 405165-61-9; Besifloxacin (Hydrochloride); Besivance. Grades: >98%. CAS No. 405165-61-9. Molecular formula: C19H21ClFN3O3.HCl. Mole weight: 430.3. | |
| Bestim TFA | Bestim TFA is an immunomodulatory dipeptide. Alternative Names: H-γ-Glu-Trp-OH trifluoroacetic acid; gamma-glutamyltryptophan trifluoroacetic acid; H-gGlu-Trp-OH trifluoroacetic acid; L-gamma-glutamyl-L-tryptophan trifluoroacetic acid. Grades: 98%. Molecular formula: C18H20F3N3O7. Mole weight: 447.36. | |
| β-ANGELICA LACTONE | β-ANGELICA LACTONE. Alternative Names: BETA-ANGELICA LACTONE; 2-Penten-4-olide; 2-Pentenoic acid, 4-hydroxy-, gamma-lactone; 4-hydroxy-2-pentanoicacigamma-lactone; 4-Hydroxy-2-pentenoic acid gamma-lactone; 4-hydroxy-2-pentenoicacidgamma-lactone. Grades: 95%. CAS No. 591-11-7. Molecular formula: C5H6O2. Mole weight: 98.1. | |
| β,β-dimethyl-acry-lalkannin | β,β-dimethyl-acry-lalkannin. CAS No. 34539-65-6. | |
| β-chamigrenic acid | β-Chamigrenic acid is an extensively utilized natural compound used in studying inflammatory ailments like rheumatoid and arthritand inflammatory bowel disease. Alternative Names: Spiro[5.5]undec-2-ene-3-carboxylic acid, 7,7-dimethyl-11-methylene-, (6S)-. Grades: >98%. CAS No. 74042-14-1. Molecular formula: C15 H22 O2. Mole weight: 234.33. | |
| β-D-Glucopyranoside,(3β,6α,16β,20R,24S)-3-[(3,4-di-O-acetyl-β-D-xylopyranosyl)oxy]-20, 24-epoxy-16,25-dihydroxy-9,19-cyclolanostan-6-yl | β-D-Glucopyranoside,(3β,6α,16β,20R,24S)-3-[(3,4-di-O-acetyl-β-D-xylopyranosyl)oxy]-20, 24-epoxy-16,25-dihydroxy-9,19-cyclolanostan-6-yl is extracted from roots of Astragalus membranaceus (Fisch.) Bunge. Alternative Names: 3-O-3',4'-Diacetyl-beta-D-xylopyranosyl-6-O-beta-D-glucopyranosyl-cycloastragenol. Grades: >98%. CAS No. 1324005-51-7. Molecular formula: C45H72O16. Mole weight: 869. | |
| β-D-Tocopherol | β-D-Tocopherol is a form of vitamin E, a class of eight fat-soluble compounds. Uses: Vitamins. Alternative Names: 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, (2R)-; (2R)-3,4-Dihydro-2,5,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol; 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,8-trimethyl-2-(4,8,12-trimethyltridecyl)-, [2R-[2R*(4R*,8R*)]]-; 6-Chromanol, 2,5,8-trimethyl-2-(4,8,12-trimethyltridecyl)-, (+)-; (R,R,R)-β-Tocopherol; D-β-Tocopherol; d-β-Tocopherol. Grades: ≥95%. CAS No. 16698-35-4. Molecular formula: C28H48O2. Mole weight: 416.69. | |
| β-Endorphin rat TFA | β-Endorphin rat TFA. | |
| Betahistine | Betahistine is a H1 receptor agonist, which serves as a vasodilator. It is used in Meniere disease and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers. It is an antivertigo drug first used for treating vertigo. It is also commonly used for patients with balance disorders. It is believed to act by reducing the asymmetrical functioning of sensory vestibular organs as well as by increasing vestibulocochlear blood flow. It also acts as a histamine H3-receptor antagonist which causes an increased output of histamine from histaminergic nerve endings which can further increase the direct H1-agonist activity. It has been listed. Uses: Betahistine is used in meniere disease and in vascular headaches. it is an antivertigo drug first used for treating vertigo. it is also commonly used for patients with balance disorders. Alternative Names: N-methyl-2-pyridin-2-ylethanamine. Grades: 98 %. CAS No. 5638-76-6. Molecular formula: C8H12N2. Mole weight: 136.19. | |
| Betamethasone EP Impurity D | Betamethasone EP Impurity D is an intrinsic impurity present in the pharmaceutical drug Betamethasone. Betamethasone serves a multitude of purposes, particularly catering to the therapy of inflammatory cutaneous ailments encompassing eczema and psoriasis. Alternative Names: Betamethasone 21-(ethyl carbonate); Betamethasone, 21-(ethyl carbonate); Betamethasone 21-O-Ethyl Carbonate; 9-fluoro-11beta,17-dihydroxy-16beta-methyl-3,20-dioxopregna-1,4-dien-21-yl ethoxycarboxylate; Pregna-1,4-diene-3,20-dione, 21-((ethoxycarbonyl)oxy)-9-fluoro-11,17-dihydroxy-16-methyl-, (11beta,16beta)-. Grades: > 95%. CAS No. 52619-05-3. Molecular formula: C25H33FO7. Mole weight: 464.54. | |
| β-Muricholic acid | β-Muricholic acid is a murine-specific primary bile acid. Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet. Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones. Alternative Names: 5β-cholanic acid-3α,6β,7β-triol; 3α,6β,7β-Trihydroxy-5β-cholan-24-oic Acid; 3α,6β,7β-Trihydroxy-5β-cholanic Acid; (3α,5β,6β,7β)-3,6,7-Trihydroxycholan-24-oic Acid; beta-muricholic acid; β-MCA. Grades: >99%. CAS No. 2393-59-1. Molecular formula: C24H40O5. Mole weight: 408.57. | |
| (βR,δR,1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic acid-[d3] sodium salt | (βR,δR,1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic acid-[d3] sodium salt is a labelled metabolite of Lovastatin. Lovastatin is a fungal metabolite and an inhibitor of HMG-CoA reductase. Lovastatin is an antihypercholesterolemic agent. Alternative Names: Sodium (3R,5R)-7-((1S,2S,6R,8S,8aR)-2,6-dimethyl-8-((2-(methyl-d3)butanoyl)oxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-3,5-dihydroxyheptanoate; (3R,5R)-7-[(1S,2S,6R,8S,8aR)-2,6-Dimethyl-8-(2-methylbutanoyloxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid-d3 sodium salt. Grades: 98% by CP; 98% atom D. CAS No. 1217528-38-5. Molecular formula: C24H34D3NaO6. Mole weight: 447.56. | |
| Betrixaban | A direct factor Xa inhibitor used as an oral anticoagulant drug. It has been prescribed as a venous thromboembolism (VTE) prophylactic for adult patients with moderate to severe restricted motility or with other risks for VTE. Uses: Factor xa inhibitors. Alternative Names: PRT054021; PRT 054021; PRT-054021; MK-4448; MK 4448; MK4448; PRT-021; PRT 021; PRT021; MLN-1021; MLN 1021; MLN1021; Bevyxxa; N-(5-chloropyridin-2-yl)-2-[[4-(N,N-dimethylcarbamimidoyl)benzoyl]amino]-5-methoxybenzamide. CAS No. 330942-05-7. Molecular formula: C23H22ClN5O3. Mole weight: 451.91. | |
| Bevantolol Hydrochloride | Bevantolol is a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension. Alternative Names: 2-Propanol,1-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-,hydrochloride; 1-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-2-propanol Hydrochloride. Grades: ≥95%. CAS No. 42864-78-8. Molecular formula: C20H28ClNO4. Mole weight: 381.89. | |
| Bevirimat | Bevirimat, also known as MPC-4326 and PA-457, is an anti-HIV drug derived from a betulinic acid-like compound, first isolated from Syzygium claviflorum, a Chinese herb. It is believed to inhibit HIV by a novel mechanism, so-called maturation inhibition. Like protease inhibitors, bevirimat and other maturation inhibitors interfere with protease processing of newly translated HIV polyprotein precursor, called gag. Bevirimat prevents this viral replication by specifically inhibiting cleavage of the capsid protein (CA) from the SP1 spacer protein. Alternative Names: MPC4326; MPC 4326; MPC-4326; PA457; PA 457; PA-457; FH11327; FH-11327; FH 11327; YK FH312; Bevirimat; YKFH312. Grades: >98%. CAS No. 174022-42-5. Molecular formula: C36H56O6. Mole weight: 584.83. | |
| BF 2649 | Pitolisant hydrochloride is an antagonist of the histamine H3 receptor, which is used for the treatment of narcolepsy with or without cataplexy in adult patients. Uses: The treatment of narcolepsy with or without cataplexy. Alternative Names: BF 2649; BF2649; BF-2649; pitolisant hydrochloride; Wakix; 1-[3-[3-(4-chlorophenyl)propoxy]propyl]piperidine hydrochloride. CAS No. 903576-44-3. Molecular formula: C17H27Cl2NO. Mole weight: 332.309. | |
| BGJ-398 | BGJ398, also known as NVP-BGJ398, is a pan FGFR kinase inhibitor, and is an orally bioavailable pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. BGJ398 selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Alternative Names: 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea; NVPBGJ398; NVPBGJ 398; NVPBGJ-398; BGJ398; BGJ-398; BG J398; Infigratinib. Grades: 0.98. CAS No. 872511-34-7. Molecular formula: C26H31Cl2N7O3. Mole weight: 560.48. | |
| BI-3406 | BI-3406 is a potent and selective inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1). SOS1 is the guanine nucleotide exchange factor (GEF) and activator of RAS, and mutants of RAS are major oncogenes and occur in many human cancers. Inhibition of SOS1 in a mutant KRAS cell line can suppress tumor growth. Alternative Names: BI 3406; BI3406. CAS No. 2230836-55-0. Molecular formula: C23H25F3N4O3. Mole weight: 462.5. | |
| BI-3812 | BI-3812 is potent and efficacious BCL6 inhibitor. It inhibits the BTB domain of BCL6 with an IC50 of ≤3 nM. The high potency and good permeability properties of BI-3812 make this molecule a very good cellular probe compound for testing hypotheses around BCL6 biology. The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies, including diffuse large B cell lymphoma (DLBCL). Alternative Names: BI-3812; 2166387-64-8; CHEMBL4755229; 1-(5-chloro-4-((8-methoxy-1-methyl-3-(2-(methylamino)-2-oxoethoxy)-2-oxo-1,2-dihydroquinolin-6-yl)amino)pyrimidin-2-yl)-N,N-dimethylpiperidine-4-carboxamide; SCHEMBL20284237; AMY16876; BCP31903; EX-A2841; BDBM50546197; s8735; AKOS040741329; SB40386; BI 3812; BI3812; AC-31571; MS-30157; HY-111381; CS-0040299; A935150; EN300-22885148; Z3417458909; 1-[5-chloro-4-({8-methoxy-1-methyl-3-[(methylcarbamoyl)methoxy]-2-oxo-1,2-dihydroquinolin-6-yl}amino)pyrimidin-2-yl]-N,N-dimethylpiperidine-4-carboxamide; 1-[5-Chloro-4-({8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxo-1,2-dihydro-6-quinolinyl}amino)-2-pyrimidinyl]-N,N-dimethyl-4-piperidinecarboxamide; 1-[5-chloro-4-[[8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxoquinolin-6-yl]amino]pyrimidin-2-yl]-N,N-dimethylpiperidine-4-carboxamide. Grades: ≥98%. CAS No. 2166387-64-8. Molecular formula: C26H32ClN7O5. Mole weight: 558.03. | |
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