MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| FSL-1 | FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 322455-70-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2036. |  |
| FSLLRY-NH2 | FSLLRY-NH2 is a protease-activated receptor 2 (PAR2) inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 245329-02-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P1260. | |
| FT011 | FT011 is an anti-fibrotic agent, reduces mRNA expression of collagens I and III and inhibits collagen synthesis[1]. FT011 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Asengeprast. CAS No. 1001288-58-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100495. | |
| FT113 | FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme. In cell-based assay, FT113 blocks FASN activity in BT474 cells (IC50, 90 nM). FT113 shows anti-proliferative activity, and exhibits anti-cancer activity both in vitro and in vivo[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1630808-89-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111551. | |
| FT206 | FT206 is the inhibitor for ubiquitin-specific protease that inhibits USP28 and USP25 with IC50s of 0.15 μM and 1.01 μM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2278274-34-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138698. | |
| FT709 | FT709 is a potent and selective USP9X inhibitor, an IC50 of 82 nM. USP9X has been linked with centrosome function, chromosome alignment during mitosis, EGF receptor degradation, chemo-sensitization, and circadian rhythms[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2413991-74-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145967. | |
| FT895 | FT895 is a potent and selective HDAC11 inhibitor with an IC50 of 3 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2225728-57-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112285. | |
| FT-FAPI-12_9 | FT-FAPI-12_9 is a FAP ligand that can be used to synthesize FAPI-46, a radiotracer targeting FAP[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2883407-81-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-164316. | |
| FTI 276 TFA | FTI 276 TFA is a farnesyltransferase (FTase) inhibitor with an IC50 of 0.5 nM, and it exhibits selectivity for FTase over geranylgeranyltransferase I (GGTase I). FTI 276 TFA blocks the farnesylation of H-Ras and K-Ras4B, causes inactive Ras-Raf complexes to accumulate in the cytoplasm, and inhibits constitutive MAPK activation. FTI 276 TFA reduces the number, incidence and volume of tumors, and restricts the growth of tumors expressing activated K-ras. FTI 276 TFA can be used in research related to pulmonary adenoma[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1217471-51-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15873A. | |
| FTI-277 hydrochloride | FTI-277 hydrochloride is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 hydrochloride can inhibit hepatitis delta virus (HDV) infection. Uses: Scientific research. Category: Signaling pathways. CAS No. 180977-34-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15872A. | |
| FTIDC | FTIDC is an orally active, noncompetitive, selective allosteric metabotropic glutamate receptor (mGluR) 1 antagonist with an IC50 of 5.8 nM for human mGluR1a. FTIDC has no species differences in its antagonistic activity on recombinant human, mouse, and rat mGluR1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 873551-53-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-100405. | |
| FTO-IN-3 | FTO-IN-3 is a FTO inhibitor that impair self-renewal in glioblastoma stem cells. Uses: Scientific research. Category: Signaling pathways. CAS No. 2585198-87-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-132865. | |
| FTT5 | FTT5 is an ionizable lipid that can be used to prepare lipid nanoparticles for efficient delivery of long-chain mRNA in vivo[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2328129-27-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145793. | |
| FTY720 (S)-Phosphate | FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (S)-FTY720P; (S)-FTY720 phosphate. CAS No. 402616-26-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15382. | |
| FUBP1-IN-1 | FUBP1-IN-1 is a potent FUSE binding protein 1 (FUBP1) inhibitor which interferes with the binding of FUBP1 to its single stranded target DNA FUSE sequence , with an IC50 value of 11.0 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 883003-62-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100758. | |
| Fucoidan | Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9072-19-9. Pack Sizes: 100 mg; 500 mg. Product ID: HY-132179. | |
| (-)-Fucose | (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interactions. (-)-Fucose is orally active, inhibits CL11-induced inflammatory response in kidney and tumor growth[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 6-Desoxygalactose; L-(-)-Fucose; L-Galactomethylose. CAS No. 2438-80-4. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-N1480. | |
| Fucosterol | Fucosterol is a sterol isolated from algae, seaweed or diatoms. Fucosterol exhibits various biological activities, including antioxidant, anti-adipogenic, blood cholesterol reducing, anti-diabetic and anti-cancer activities[1][2]. Fucosterol regulates adipogenesis via inhibition of PPARα and C/EBPα expression and can be used for anti-obesity agents development research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 17605-67-3. Pack Sizes: 10 mM * 1 mL in Ethanol; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N4103. | |
| Fucoxanthin | Fucoxanthin (all-trans-Fucoxanthin) is a marine carotenoid and shows anti-obesity, anti-diabetic, anti-oxidant, anti-inflammatory and anticancer activities[1][2][3][4][5][6][7][8][9]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: all-trans-Fucoxanthin. CAS No. 3351-86-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2302. | |
| Fulacimstat | Fulacimstat is an orally available chymase inhibitor, with IC50s of 4, 3 nM for human and hamster chymase enzyme, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY1142524. CAS No. 1488354-15-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109059. | |
| Fulvestrant | Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ICI 182780; ZD 9238; ZM 182780. CAS No. 129453-61-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-13636. | |
| Fulvestrant (Standard) | Fulvestrant (Standard) is the analytical standard of Fulvestrant. This product is intended for research and analytical applications. Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ICI 182780(Standard); ZD 9238(Standard); ZM 182780 (Standard). CAS No. 129453-61-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13636R. | |
| Fulvic Acid | Fulvic Acid is a natural product, which comes from humic substances produced by microorganisms in soil. Fulvic Acid can modulate the immune system, influence the oxidative state of cells, and improve gastrointestinal function. Fulvic Acid has the potential for researching chronic inflammatory diseases, including diabetes[1][2]. Uses: Scientific research. Category: Natural products. CAS No. 479-66-3. Pack Sizes: 1 mg. Product ID: HY-122515. | |
| Fumarate hydratase-IN-1 | Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor. Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1644060-37-6. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-100004. | |
| Fumaric acid | Fumaric acid is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid can be used in the study of pregnancy-induced hypertension[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 110-17-8. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g; 50 g; 100 g; 500 g. Product ID: HY-W015883. | |
| Fumaric acid-13C4 | Fumaric acid-13C4 is the 13C-labeled Fumaric acid. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite. Uses: Scientific research. Category: Signaling pathways. CAS No. 201595-62-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-W015883S. | |
| Fumaric acid (Standard) | Fumaric acid (Standard) is the analytical standard of Fumaric acid. This product is intended for research and analytical applications. Fumaric acid is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid can be used in the study of pregnancy-induced hypertension[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 110-17-8. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-W015883R. | |
| Fumitremorgin C | Fumitremorgin C is a potent and selective ABCG2/BRCP inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 12α-Fumitremorgin C. CAS No. 118974-02-0. Pack Sizes: 10 mM * 1 mL in DMSO; 250 μg; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N2143. | |
| Fumonisin B1 | Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin[1][2]. Uses: Scientific research. Category: Induced disease models products. CAS No. 116355-83-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N6719. | |
| Fumonisin B2 | Fumonisin B2 is a selective ceramide synthase inhibitor and carcinogenic mycotoxin with toxicity comparable to that of Fumonisin B1 (HY-N6719). Fumonisin B2 inhibits de novo sphingolipid biosynthesis by blocking the amide bond formation between fatty acids and dihydrosphingosine, which leads to a massive intracellular accumulation of free dihydrosphingosine, altered sphingosine levels, subsequent inhibition of cell proliferation, and induction of cell death. Fumonisin B2 is used to investigate the pathogenesis of diseases associated with Fusarium verticillioides contamination, including equine leukoencephalomalacia, porcine pulmonary edema syndrome, human esophageal cancer, and rat hepatocellular carcinoma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 116355-84-1. Pack Sizes: 500 μg; 1 mg. Product ID: HY-N6723. | |
| Funapide | Funapide (TV 45070; XEN402) is an orally active inhibitor of voltage-gated sodium channels (VGSC) in the peripheral nervous system with IC50 values ??of 84 nM and 54 nM for Nav1.5 and Nav1.7, respectively. Funapide has analgesic effects[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TV 45070; XEN402. CAS No. 1259933-16-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16723. | |
| Funobactam | Funobactam (XNW4107) is a β-lactamase inhibitor, can be used for researching anti-bacteria[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: XNW4107. CAS No. 2365454-12-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-147274. | |
| Fura-2 AM | Fura-2 AM is a membrane permeable, intracellular, UV light-excitable and ratiometric fluorescent Ca2+ (calcium ion) indicator. Fura-2 AM crosses cell membranes and is converted to Fura-2 (HY-D0110A) via cellular esterases. Fura-2 AM can be used to detect calcium in cells. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Fura-2 Acetoxymethyl ester. CAS No. 108964-32-5. Pack Sizes: 1 mg. Product ID: HY-101897. | |
| Fura-2 pentapotassium | Fura-2 pentapotassium is a cell-impermeable scaled fluorescent dye that can be used for intracellular calcium imaging. Fura-2 pentapotassium has an emission wavelength of 510 nm and excitation wavelengths of 340 nm or 380 nm and the ratio of 340/380 fluorescence intensity is proportional to the intracellular Ca2+ level[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 113694-64-7. Pack Sizes: 500 μg; 1 mg. Product ID: HY-D0110A. | |
| Fura-FF pentapotassium | Fura-FF pentapotassium is a low-affinity fluorescent dye for calcium (Ex/Em: 365/514 nm in the absence of calcium; 339/507 nm in the presence of a high calcium concentration)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 192140-58-2. Pack Sizes: 50 μg. Product ID: HY-135239. | |
| Furafylline | Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 80288-49-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107204. | |
| Furamidine dihydrochloride | Furamidine dihydrochloride (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine dihydrochloride is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 283 μM, and >400 μM, respectively). Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DB75 dihydrochloride; NSC 305831 dihydrochloride. CAS No. 55368-40-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110137. | |
| Furaneol | Furaneol is mainly isolated from American grape (Vitis labrusca) and its hybrid grape. Furaneol is an important aroma compound in fruits and contribute to the strawberry-like note in some wines[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Strawberry furanone. CAS No. 3658-77-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g. Product ID: HY-N7093. | |
| Furanodiene | Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae. Furanodiene plays anti-cancer effects through anti-angiogenesis and inducing ROS production, DNA strand breaks and apoptosis. Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 19912-61-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-126940. | |
| Fura Red AM | Fura Red AM is a fluorescent probe that can be used to visualize Ca2+ distribution in the cytoplasm of undifferentiated cells. Fura Red AM operates at an excitation wavelength of 488 nm[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 218280-33-2. Pack Sizes: 50 μg * 2; 50 μg * 10; 1 mg. Product ID: HY-D1903. | |
| Furobufen | Furobufen, an anti-inflammatory agent, produces antiarthritic, antipyretic effects. Furobufen has an analgesic effect in inflamed tissue[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 38873-55-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105808. | |
| Furosemide | Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2[1]. Furosemide is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema[2]. Uses: Scientific research. Category: Induced disease models products. CAS No. 54-31-9. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0135. | |
| Fursultiamine | Fursultiamine is a vitamin B1 derivative, has anti-nociceptive and antineoplastic activity. Fursultiamine can be used for vitamin B1?deficiency, osteoarthritis (OA) and cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 804-30-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B2082. | |
| Fusidic acid | Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome. Fusidic acid holds promise for research in anticancer and anti-infective applications.[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Fusidate; SQ-16603. CAS No. 6990-6-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B1350. | |
| Fusidic acid sodium salt | Fusidic acid sodium salt is an orally available antibacterial agent that inhibits bacterial protein synthesis by preventing the release of translation elongation factor G (EF-G) from ribosomes. Fusidic acid sodium salt inhibits the inhibitory and activating effects of interleukins IL-1 and IL-6 on glucose-induced insulin production and exhibits antidiabetic effects in a rat model. Fusidic acid sodium salt improves the symptoms of colitis in rats and inhibits the growth of Toxoplasma gondii and Listeria monocytogenes EGD in vitro, but not in mice[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Sodium fusidate; SQ-16360. CAS No. 751-94-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B1350A. | |
| Fusion Inhibitory Peptide | Fusion Inhibitory Peptide (Z-D-Phe-Phe-Gly-OH, FIP, Virus Replication Inhibitory Peptide) is a potent inhibitor of the virus replication, by inhibiting the membrane fusing activity of a viral glycoprotein[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Z-D-Phe-Phe-Gly-OH; FIP; Virus Replication Inhibitory Peptide. CAS No. 75539-79-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-114437. | |
| Futibatinib | Futibatinib (TAS-120) is an orally bioavailable, highly selective, and irreversible FGFR inhibitor, with IC50s of 3.9, 1.3, 1.6, and 8.3 nM for FGFR 1-4, respectively. Futibatinib inhibits mutant and wild-type FGFR2 with similar IC50s (wild-type FGFR2=0.9?nM; V5651=1-3?nM; N550H=3.6?nM; E566G=2.4?nM)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TAS-120. CAS No. 1448169-71-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100818. | |
| Futuximab | Futuximab is a chimeric monoclonal antibody targeting non-overlapping epitopes on EGFR. Futuximab has antineoplastic activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1310460-85-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99628. | |
| FW1256 | FW1256 is a phenyl analogue and a slow-releasing hydrogen sulfide (H2S) donor. FW1256 inhibits NF-κB activity and induces cell apoptosis. FW1256 exerts potent anti-inflammatory effects and has the potential for cancer and cardiovascular disease treatment[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 117089-08-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-121955. | |
| FX-11 | FX-11 is a potent, selective, reversible and competitive lactate dehydrogenase A (LDHA) inhibitor, with a Ki of 8 μM. FX-11 reduces ATP levels and induces oxidative stress, ROS production and cell death. FX-11 shows antitumor activity in lymphoma and pancreatic cancer xenografts[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LDHA Inhibitor FX11. CAS No. 213971-34-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16214. | |
| FX-909 | FX-909 is a covalent peroxisome proliferator-activated receptor gamma (PPARG) inverse agonist. FX-909 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2924573-90-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153344. | |
| Fz7-21 | Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt-β-catenin signalling and stem cell function in intestinal organoids[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ac-LPSDDLEFWCHVMY-NH2. CAS No. 2247635-23-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P1454. | |
| FzM1 | FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=?6.2). FzM1 binds to an allosteric binding site located in intracellular loop 3 (ICL3) of FZD4 and alters the conformation of the receptor, ultimately inhibiting the WNT/β-catenin cascade[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1680196-54-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116553. | |
| FzM1.8 | FzM1.8, derives from FzM1, is an allosteric agonist of FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2204290-85-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117163. | |
| G007-LK | G007-LK is a potent and selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1380672-07-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12438. | |
| G0507 | G0507, a pyrrolopyrimidinedione compound, is a potent LolCDE ABC Transporter inhibitor. G0507 is a inhibitor of Escherichia coli growth and induces the extracytoplasmic σE stress response. G0507 acts as a chemical probe to dissect lipoprotein trafficking in Gram-negative bacteria[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1223998-29-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-124658. | |
| G0-C14 | G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for agent and vaccine delivery[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1510653-27-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152229. | |
| G-1 | G-1 is a nonsteroidal, high-affinity and selective agonist of GPR30 with a Ki of 11 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 881639-98-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107216. | |
| G140 | G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0?nM and 442?nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2369751-07-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-133916. | |
| G15 | G15 is a high affinity and selective G-protein-coupled estrogen receptor (GPER/GPR30) antagonist with a Ki of 20 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1161002-05-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103449. | |
| G150 | G150 is a highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with an IC50 of 10.2 nM. G150 represses dsDNA-triggered interferon expression, and G150 can be used for the research of inflammatory[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2369751-30-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-128583. | |
| G244-LM | G244-LM is a potent and specific inhibitor of tankyrase 1/2 that inhibits Wnt signaling[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1563007-08-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-117705. | |
| G36 | G-36 is a cell-permeable nonsteroidal antagonist of the G protein-coupled estrogen receptor (GPER/GPR30), which selectively inhibits estrogen-mediated PI3K activation through GPER, rather than Erα. G-36 also inhibits estrogen-mediated calcium mobilization (IC50=112 nM). G-36 is promising for research in the field of cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1392487-51-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103450. | |
| G3-CNP | G3-CNP is an α-amylase substrate. The absorbance of G3-CNP cleavage product 2-chloro-4-nitrophenol is measured at 405 nm, which can be used to detect enzyme activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 118291-90-0. Pack Sizes: 25 mg; 100 mg. Product ID: HY-153102. | |
| G-418 | G-418 (Geneticin) is an aminoglycoside antibiotic with a structure similar to gentamicin. It is toxic to both eukaryotic and prokaryotic cells and works by interfering with protein synthesis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Geneticin; Antibiotic G-418. CAS No. 49863-47-0. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-108718. | |
| G-418 disulfate | G-418 disulfate (Geneticin sulfate), is an aminoglycoside antibiotic, inhibits protein synthesis in eukaryotes and prokaryotes. G-418 disulfate is commonly used as a selective agent for eukaryotic cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Geneticin sulfate; Antibiotic G-418 sulfate. CAS No. 108321-42-2. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g; 5 g. Product ID: HY-17561. | |
| G-418 disulfate (Standard) | G-418 (disulfate) (Standard) is the analytical standard of G-418 (disulfate). This product is intended for research and analytical applications. G-418 disulfate (Geneticin sulfate), is an aminoglycoside antibiotic, inhibits protein synthesis in eukaryotes and prokaryotes. G-418 disulfate is commonly used as a selective agent for eukaryotic cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Geneticin sulfate (Standard); Antibiotic G-418 sulfate (Standard). CAS No. 108321-42-2. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-17561R. | |
| G4RGDSP, integrin-binding peptide | G4RGDSP, Integrin-binding peptide is a cell integrin-binding peptide that targets integrin receptors. G4RGDSP, integrin-binding peptide is coupled to alginate to increase the viability of cells in the scaffold. G4RGDSP, integrin-binding peptide can be used as an extrudable carrier for chondrocyte delivery for the study of 3D printing technology[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 774577-43-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P6022. | |
| G-5555 | G-5555 is a potent p21-activated kinase 1 (PAK1) inhibitor with Kis of 3.7 nM and 11 nM for PAK1 and PAK2, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1648863-90-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-19635. | |
| G-5555 hydrochloride | G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 2319590-15-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19635A. | |
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