MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| G6PD activator AG1 | G6PD activator AG1 is a potent and selective glucose-6-phosphate dehydrogenase (G6PD) agonist with an EC50 of 3 μM. G6PD is an oxidoreductase that catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconolactone and the simultaneous reduction of NAD phosphate (NADP) to reduced NADP (NADPH). G6PD activator AG1 can reduce hemolysis of human erythrocytes[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 421581-52-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123962. |  |
| G6PDi-1 | G6PDi-1 is a reversible and non-competitive glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC50 of 0.07 μM for human G6PD. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytokine production in T cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2457232-14-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W107464. | |
| G907 | G907 is a selective antagonist of ATP-binding cassette (ABC) transporter MsbA with anti-microbial activity. G907 inhibits E. coli MsbA with an IC50 value of 18 nM. G907 traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2244035-16-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-125176. | |
| GA-017 | GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2351906-74-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147082. | |
| GA3-AM | GA3-AM is a cell permeable analog of the plant hormone gibberellic acid that acts as a chemical dimerizer or chemical inducer of dimerization[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1373154-68-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-126558. | |
| Gabapentin | Gabapentin is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin inhibits neuronal Ca2+ influx and reduction of neurotransmitter release. Gabapentin is a GABA analog that can be used to relieve neuropathic pain[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 60142-96-3. Pack Sizes: 10 mM * 1 mL in Water; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0057. | |
| Gabapentin-d4 | Gabapentin-d4 is the deuterium labeled Gabapentin. Gabapentin (Neurontin) is a pharmaceutical agent, specifically a GABA analog. It was originally developed to treat epilepsy, and currently is also used to relieve neuropathic pain. Uses: Scientific research. Category: Signaling pathways. CAS No. 1185039-20-6. Pack Sizes: 1 mg. Product ID: HY-A0057S. | |
| Gabapentin hydrochloride | Gabapentin hydrochloride is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin hydrochloride inhibits neuronal Ca2+ influx and reduction of neurotransmitter release. Gabapentin hydrochloride is a GABA analog that can be used to relieve neuropathic pain[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 60142-95-2. Pack Sizes: 10 mM * 1 mL in Water; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-A0057A. | |
| Gabazine | Gabazine is a selective and competitive antagonist of GABAA receptor, with an IC50 of ~0.2 μM for GABA receptor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SR95531. CAS No. 104104-50-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103533. | |
| Gabexate mesylate | Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with Kis of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with Kis of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FOY. CAS No. 56974-61-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0385. | |
| Gaboxadol hydrochloride | Gaboxadol hydrochloride (Lu 02-030 hydrochloride) is a potent agonist of the GABAA receptor and an antagonist of GABAC receptors (IC50=25 μM). Gaboxadol hydrochloride displays a partial agonist efficacy on subunit α1β2γ2 with an ED50 value of 143 μM, a full agonist efficacy at α5 subunit (ED50=28-129 μM) and a superagonist efficacy at α4β3δ (ED50=6 μM). Gaboxadol hydrochloride is a non-opioid agent[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Lu 02-030 hydrochloride; THIP hydrochloride. CAS No. 85118-33-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10233. | |
| GAL-021 | GAL-021 is a potent BKCa-channel blocker. GAL-021 inhibits KCa1.1 in GH3 cells. GAL-021 is a novel breathing control modulator that is based on selective modification of the almitrine pharmacophore. GAL-021 increases minute ventilation in rats and non-human primates[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1380341-99-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101422. | |
| GALA | GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. GALA significantly promotes the cytosolic release of cargos carried by exosomes, plasmids and liposomes, effectively enhances gene transfection efficiency, and drives gene knockdown of functional macromolecules (such as siRNA) in alveolar epithelial cells (with no significant cytotoxicity at effective concentrations). GALA serves as a critical tool for studies on lung cancer metastasis (e.g., melanoma lung metastasis) and lung-targeted drug delivery systems[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 107658-43-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5423. | |
| Galactose Oxidase, Dactylium dendroides | Galactose Oxidase, Dactylium dendroides (GOase) from fungus is often used in biochemical studies. Galactose oxidase is a type II copper metalloenzyme, and it containing a single polypeptide. Galactose oxidase catalyzes two-electron oxidation of primary alcohols to their corresponding aldehydes, coupling with the reduction of dioxygen to hydrogen peroxide[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GOase. CAS No. 9028-79-9. Pack Sizes: 50 U; 150 U; 450 U. Product ID: HY-P2910. | |
| Galangin | Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor. Galangin (Norizalpinin) also shows inhibition of CYP1A1 activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Norizalpinin; 3,5,7-Trihydroxyflavone. CAS No. 548-83-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0382. | |
| Galanin (1-30), human | Galanin (1-30), human is a 30-amino acid neuropeptide, and acts as an agonist of GalR1 and GalR2 receptors, with Kis of both 1 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Glanin. CAS No. 119418-04-1. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-P1127. | |
| Galanthamine | Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Galantamine. CAS No. 357-70-0. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-76299. | |
| Galanthamine hydrobromide | Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC50 of 0.35 μM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α3β4, α4β2, α6β4 nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Galantamine hydrobromide. CAS No. 1953-4-4. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg. Product ID: HY-A0009. | |
| Galanthaminone | Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Narwedine; Narwedin. CAS No. 510-77-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-I0020. | |
| Galcanezumab | Galcanezumab (LY 2951742) is a humanized IgG4 monoclonal antibody against the CGRP ligand. Galcanezumab can be used for migraine or cluster headaches research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY 2951742. CAS No. 1578199-75-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99021. | |
| Galectin-3 antagonist 1 | Galectin-3 antagonist 1 (compound 15) is a potent and selective Galectin-3 (Gal-3) antagonist with Kd value of 5.3 μM. Meanwhile, Galectin-3 antagonist 1 binds to various Galectin with Kd values of 250 μM (Gal-4N), 18 μM (Gal-4C), 450 μM (Gal-8C), respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2921603-03-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146808. | |
| Galectin-3/galectin-8-IN-1 | Galectin-3/galectin-8-IN-1 (Compound 53) is a dual Galectin-3 and galectin-8 C-terminal domain inhibitor, with Kd values of 4.12 μM and 6.04 μM respectively. Galectin-3/galectin-8-IN-1 inhibits the MRC-5 lung fibroblast cells migration. Galectin-3/galectin-8-IN-1 can be used for research of cancer and tissue fibrosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3053895-85-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155191. | |
| Galegenimab | Galegenimab (FHTR 2163) is a humanized monoclonal antibody Fab fragment targeting the HtrA1 trimer. Galegenimab is used in research on age-related macular degeneration (AMD)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FHTR 2163; RG 6147; RO 7171009. CAS No. 2403683-24-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99629. | |
| Galegine hemisulfate | Galegine hemisulfate, a guanidine derivative, contributes to weight loss in mice. Galegine hemisulfate activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hemisulfate has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 14279-86-8. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg. Product ID: HY-N0930A. | |
| Galeterone | Galeterone (TOK-001) is a potent, orally active molecular glue degrader, which degrades androgen receptor (AR) and its splice variants (AR-Vs) and MAP kinase-interacting serine/threonine protein kinase Mnk1/2. Galeterone also functions as a CYP17 inhibitor (IC50 = 47 nM). Galeterone induces cell apoptosis. Galeterone inhibits tumor growth in human prostate cancer xenograft mouse models. Galeterone can be used for castration resistant prostate cancer (CRPC) and pancreatic ductal adenocarcinoma (PDAC) research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TOK-001; VN-124-1. CAS No. 851983-85-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-70006. | |
| Galidesivir | Galidesivir (BCX4430), an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. Galidesivir inhibits some negative-sense RNA viruses with EC50s ranging from ~3 to ~68 μM[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BCX4430; Immucillin-A. CAS No. 249503-25-1. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg. Product ID: HY-18649A. | |
| Galidesivir hydrochloride | Galidesivir (BCX4430) hydrochloride, an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir hydrochloride is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. Galidesivir hydrochloride inhibits some negative-sense RNA viruses with EC50s ranging from ~3 to ~68 μM[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BCX4430 hydrochloride; Immucillin-A hydrochloride. CAS No. 222631-44-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18649. | |
| Galiximab | Galiximab (IDEC-114) is a primatized monoclonal IgG1 antibody targeting CD80. Galiximab variable regions are primatized, and the constant regions are humanized. Galiximab induces antibody-dependent cellular cytotoxicity by blocking CD80-CD28 binding. Galiximab has antitumor activity and can induce apoptosis in tumor cells. Galiximab can be used in the research of relapsed Hodgkin lymphoma and solid tumors[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IDEC 114; Anti-Human CD80 Recombinant Antibody. CAS No. 357613-77-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99293. | |
| GALK1-IN-1 | GALK1-IN-1 (Compound 4) is a galactokinase inhibitor (IC50: 4.2129 μM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 669718-48-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-128047. | |
| Gallamine Triethiodide | Gallamine Triethiodide is a blood-brain barrier-permeable skeletal muscle relaxant. Gallamine Triethiodide induces skeletal muscle paralysis by blocking acetylcholine. Gallamine Triethiodide directly stimulates intracardiac β receptors. Gallamine Triethiodide prolongs the duration of afterdischarge in the cat cerebral cortex. Gallamine Triethiodide can be used in studies related to convulsive disorders[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 65-29-2. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg. Product ID: HY-B0416. | |
| Gallein | Gallein is a Gβγ subunit signaling inhibitor that can interfere with the interaction between Gβγ subunit and PI3Kγ, regulate platelet function, and exhibit anti-tumor activity[1][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pyrogallol phthalein. CAS No. 2103-64-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-D0254. | |
| Gallic acid | Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2)[1]. Gallic acid has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3,4,5-Trihydroxybenzoic acid. CAS No. 149-91-7. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-N0523. | |
| Gallic acid hydrate | Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2)[1]. Gallic acid hydrate has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3,4,5-Trihydroxybenzoic acid hydrate. CAS No. 5995-86-8. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-N0523A. | |
| Gallic acid (Standard) | Gallic acid (Standard) is the analytical standard of Gallic acid. This product is intended for research and analytical applications. Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2)[1]. Gallic acid has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3,4,5-Trihydroxybenzoic acid (Standard). CAS No. 149-91-7. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0523R. | |
| (-)-Gallocatechin | (-)-Gallocatechin, an epimer of (-)-Epigallocatechin (EGC) (HY-N0225), is contained in various tea products. (-)-Gallocatechin demonstrates antioxidant activity in vitro, including inhibition of LDL oxidation and DPPH radical scavenging[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3371-27-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0521. | |
| (+)-Gallocatechin | (+)-Gallocatechin is a polyphenol compound from green tea, possesses anticancer activity[1]. Uses: Scientific research. Category: Natural products. CAS No. 970-73-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N0521A. | |
| (-)-Gallocatechin gallate | (-)-Gallocatechin gallate is the polyphenol isolated from tea, with cancer-preventive activities. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Gallocatechol gallate. CAS No. 4233-96-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-N0522. | |
| Gallocatechin gallate | Gallocatechin gallate is a Flavonoids product that can be isolated from the herbs of Celastrus orbiculatus[1]. Uses: Scientific research. Category: Natural products. CAS No. 5127-64-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N7727. | |
| Galloflavin | Galloflavin is a potent lactate dehydrogenase (LDH) inhibitor. The calculated Kis for pyruvate are 5.46 μM (LDH-A) and 15.06 μM (LDH-B). Galloflavin hinders the proliferation of cancer cells by blocking glycolysis and ATP production[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 568-80-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W040118. | |
| Galloylpaeoniflorin | Galloylpaeoniflorin (6'-O-Galloyl paeoniflorin) is an orally active galloylated derivative of Paeoniflorin (HY-N0293) found in peony roots with various anti-inflammatory and antioxidant activities. Galloylpaeoniflorin suppresses RANKL-induced activation of ERK, JNK, c-Fos, c-Jun, and NFATc1, and reduces osteoclast-specific gene expression. Galloylpaeoniflorin activates Nrf2 and PI3K/Akt pathways, inhibits NF-κB activation, and scavenges ROS to reduce oxidative DNA, lipid, and protein damage. Galloylpaeoniflorin attenuates neuroinflammation, inhibits apoptosis, reduces Helicobacter pylori-induced gastric mucosa injury and UVB-induced cell damage. Galloylpaeoniflorin can be used for the research of osteoporosis, gastritis, ischemic stroke and skin diseases[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 6'-O-Galloyl paeoniflorin. CAS No. 122965-41-7. Pack Sizes: 5 mg. Product ID: HY-N5048. | |
| GalNAc-NAG37 phosphoramidite | GalNAc-NAG37 phosphoramidite is an N-acetylgalactosamine (GalNAc) derivative that acts as a ligand for the asialoglycoprotein receptor (ASGPR). GalNAc-NAG37 phosphoramidite can be used to synthesize GalNAc-siRNA and for oligonucleotide delivery[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2199491-27-3. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-173247. | |
| Galunisertib | Galunisertib (LY2157299) is an oral and selective TGF-β receptor type I (TGF-βRI) kinase inhibitor with an IC50 of 56 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY2157299. CAS No. 700874-72-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-13226. | |
| Galvokimig | Galvokimig is an anti-IL13/IL17A/ALB/IL17B monoclonal antibody[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UCB-9741. CAS No. 2648456-30-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990741. | |
| Gamabufotalin | Gamabufotalin (Gamabufagin), a main active compound isolated from Chinese medicine Chansu, has been shown to strongly inhibit cancer cell growth and inflammatory response. Gamabufotalin could inhibite angiogenesis by inhibiting the activation of VEGFR-2 signaling pathways. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Gamabufagin. CAS No. 465-11-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N0883. | |
| Gambogenic acid | Gambogenic acid is an active ingredient that can be isolated from gamboge. Gambogenic acid acts as an effective inhibitor of EZH2, specifically and covalently binds to Cys668 within the EZH2-SET domain, and induces EZH2 ubiquitination. Gambogenic acid can be used for the research of cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 173932-75-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N5024. | |
| Gambogic Acid | Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Beta-Guttiferrin. CAS No. 2752-65-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0087. | |
| Gambogic amide | Gambogic amide is a potent and selective agonist of TrkA and also induces its tyrosine phosphorylation and activation of downstream signaling, including Akt and MAPK. Gambogic amide specifically interacts with the cytoplasmic juxtamembrane domain of the TrkA receptor and triggers its dimerization, leading to activation. Gambogic amide has neuroprotective activity preventing glutamate-induced neuronal cell death. Gambogic amide has improved efficacy in a transient middle cerebral artery occlusion model of stroke and could be used to study neurodegenerative diseases and stroke[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 286935-60-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-121833. | |
| Gamcemetinib | Gamcemetinib (CC-99677) is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM). Gamcemetinib is extracted from patent WO2020236636, compound 1[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CC-99677. CAS No. 1887069-10-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139504. | |
| Gamithromycin | Gamithromycin is an antimicrobial agent which can inhibit the growth of MmmSC strains B237 and Tan8 with MICs of 0.00012 and 0.00006 μg/mL, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ML-1709460. CAS No. 145435-72-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108365. | |
| Gamitrinib TPP hexafluorophosphate | Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 1131626-47-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-102007A. | |
| γ-1-Melanocyte Stimulating Hormone (MSH), amide | γ-1-Melanocyte Stimulating Hormone (MSH), amide is a 11-amino acid peptide. γ-1-Melanocyte Stimulating Hormone (MSH) regulates sodium (Na+) balance and blood pressure through activation of the melanocortin receptor 3 (MC3-R). Uses: Scientific research. Category: Signaling pathways. CAS No. 72629-65-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1531. | |
| γ-2-MSH (41-58), amide | γ-2-MSH (41-58), amide is derived from γ-2-MSH. γ-2-MSH is a twelve amino acid peptide that is derived from the N-terminal fragment of proopiomelanocortin (POMC) and contains the His-Phe-Arg-Trp motif common to all melanocortin endogenous agonist ligands[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 799841-81-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1922. | |
| γ-Amanitin | γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. γ-Amanitin competitively binds to monoclonal antibody (mAb), with an IC50 of 163.1 ng/mL. γ-Amanitin is toxic to a variety of cells[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 21150-23-2. Pack Sizes: 1 mg. Product ID: HY-131081. | |
| γ-Aminobutyric acid | γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors. γ-Aminobutyric acid shows calming effect by blocking specific signals of central nervous system[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4-Aminobutyric acid. CAS No. 56-12-2. Pack Sizes: 10 mM * 1 mL in Water; 100 mg. Product ID: HY-N0067. | |
| γ-Aminobutyric acid-d2 | γ-Aminobutyric acid-d2 is the deuterium labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain[1][2], binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors)[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4-Aminobutyric acid-d2. CAS No. 67910-98-9. Pack Sizes: 10 mg. Product ID: HY-N0067S1. | |
| γ-Aminobutyric acid-d6 | γ-Aminobutyric acid-d6 is the deuterium labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain[1][2], binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors)[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4-Aminobutyric acid-d6. CAS No. 70607-85-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0067S. | |
| γ-Cyclodextrin | γ-Cyclodextrin is an orally active cyclic oligosaccharide composed of eight glucose molecules, which can be formed by bacteria digesting starch. γ-Cyclodextrin can form water-soluble inclusion complexes with a variety of poorly soluble compounds and is widely used in fields such as pharmacy and food. In addition, γ-Cyclodextrin has good safety[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 17465-86-0. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-W040040. | |
| γ-Glu-Asn | γ-Glu-Asn (γ-Glutamylasparagine) is a calcium sensing receptor (CaSR) agonist. γ-Glu-Asn is a dipeptide composed of glutamic acid and asparagine[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: γ-Glutamylasparagine. CAS No. 38681-07-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P11200. | |
| γ-Glu-Gly | γ-Glu-Gly, a γ-glutamyl dipeptide, is a human lipid metabolite.γ-Glu-Gly has a similar structure to GABA (γ-aminobutyric acid) and can act as an antagonist of excitatory amino acids[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1948-29-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P3280. | |
| γ-Glu-His | γ-Glu-His (γ-Glutamylhistidine) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development[1]. Uses: Scientific research. Category: Peptides. Alternative Names: γ-Glutamylhistidine; H-γ-Glu-His-OH. CAS No. 37460-15-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5097. | |
| γ-Glu-Phe | γ-Glu-Phe is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: H-γ-Glu-Phe-OH; γ-Glutamylphenylalanine. CAS No. 7432-24-8. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101399. | |
| gamma-Glutamylaspartic acid | gamma-Glutamylaspartic acid (γ-Glu-Asp) is a γ-glutamyl dipeptide with kokumi activities[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: γ-Glu-Asp. CAS No. 16804-55-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P11201. | |
| Gamma-glutamylcysteine | Gamma-glutamylcysteine (γ-Glu-Cys) is an orally active, blood-brain barrier permeable dipeptide. Gamma-glutamylcysteine activates AMPK, SIRT1, IL-4/STAT6, AC/cAMP/PI3K, IGF-1R/IRS1/PI3K, and Nrf2 signaling pathways; it inhibits NF-κB, JAK1/STAT1/3, MAPKs, cadmium-induced p38 MAPK, JNK, and PI3K/Akt signaling pathways. Gamma-glutamylcysteine regulates macrophage polarization, modulates the trafficking of CD36 and GLUT4, induces glutathione synthesis, improves metabolic dysfunction, reduces lipid deposition, ameliorates glucose homeostasis, inhibits apoptosis (Apoptosis), stabilizes mitochondria, suppresses lipid peroxidation, iron accumulation and ferroptosis (Ferroptosis), reduces ds-HMGB1 levels, reverses mechanical hyperalgesia, and alleviates hepatic lipid droplet formation. Gamma-glutamylcysteine is applicable to research related to inflammatory bowel disease, type 2 diabetes, cadmium-induced neurotoxicity, Alzheimer's disease, cerebral ischemia/reperfusion injury, neuropathy, and alcoholic liver disease[1][2][3][4][5][6][8][9]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: γ-Glu-Cys. CAS No. 636-58-8. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-113402. | |
| gamma-Glutamylisoleucine | gamma-Glutamylisoleucine (γ-Glu-Ile; H-γ-Glu-Ile-OH) is a dipeptide composed of γ-glutamic acid and isoleucine, and it is also a degradation product of macromolecular proteins after proteolysis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: γ-Glu-Ile; H-γ-Glu-Ile-OH. CAS No. 23632-83-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W724905. | |
| gamma-Glutamylproline | gamma-Glutamylproline (γ-Glu-Pro) is a γ-glutamyl dipeptide with kokumi activities[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: γ-Glu-Pro. CAS No. 53411-63-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P11202. | |
| γ-Glutamyl-S-allylcysteine | γ-Glutamyl-S-allylcysteine (L-γ-Glutamyl-(S)-Allyl-Cysteine) is a naturally occurring organosulfur compound found in garlic. γ-Glutamyl-S-allylcysteine has antiglycative effect and shows radical-scavenging and metal-chelating capacities[1][2]. Uses: Scientific research. Category: Natural products. Alternative Names: L-γ-Glutamyl-(S)-Allyl-Cysteine. CAS No. 91216-95-4. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N9413. | |
| γ-Glutamylvaline | γ - Glutamylvaline (γ-Glu-Val) is a calcium - sensing receptor (CaSR) agonist. γ - Glutamylvaline activates CaSR and facilitates its binding to β - arrestin 2 to modulate inflammatory and metabolic homeostasis signaling. γ - Glutamylvaline inhibits TNF - α - induced IL - 6/MCP - 1 and enhances adiponectin/PPARγ in adipocytes. γ - Glutamylvaline upregulates Wnt5a, restores β - catenin phosphorylation, and reduces serine - phosphorylated IRS - 1 in adipocytes. γ-Glutamylvaline can be used for the research of low-grade chronic inflammation[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: γ-Glu-Val. CAS No. 2746-34-1. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg. Product ID: HY-12557. | |
| γ-Glu-Tyr | γ-Glu-Tyr, a competitive inhibitor of dipeptidyl peptidase-IV (DPP-IV) (IC50=6.77 mM), is a potentially functional component of the type 2 diabetes diet[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 7432-23-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P4633. | |
| γ-Glu-Val-Gly | γ-Glu-Val-Gly is a cleavable ADC linker. Uses: Scientific research. Category: Signaling pathways. CAS No. 38837-70-6. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-W614632. | |
| γ-L-Glutamyl-L-alanine (Standard) | γ-L-Glutamyl-L-alanine (Standard) is the analytical standard of γ-L-Glutamyl-L-alanine. This product is intended for research and analytical applications. γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is a proteolytic breakdown product of larger proteins. γ-L-Glutamyl-L-alanine is a natural substrate of the γ-Glutamylcyclotransferase. γ-L-Glutamyl-L-alanine is a positive modulator of calcium-sensing receptor (CaR) function[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: γ-Glu-Ala (Standard). CAS No. 5875-41-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112171R. | |
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