MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| GDC-0310 | GDC-0310 is a selective acyl-sulfonamide Nav1.7 inhibitor, with an IC50 of 0.6 nM for hNav1.7[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1788063-52-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139081. |  |
| GDC-0326 | GDC-0326 is a potent and selective PI3Kα inhibitor with a Ki of 0.2 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1282514-88-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101272. | |
| GDC-0339 | GDC-0339 is a potent, orally bioavailable and well tolerated pan-Pim kinase inhibitor, with Kis of 0.03 nM, 0.1 nM and 0.02 nM for Pim1, Pim2 and Pim3, respectively. GDC-0339 is discovered as a potential treatment of multiple myeloma[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1428569-85-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16976. | |
| GDC-0575 | GDC-0575 (ARRY-575, RG7741) is a highly-selective oral small-molecule Chk1 inhibitor with an IC50 of 1.2 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ARRY-575; RG7741. CAS No. 1196541-47-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112167. | |
| GDC-0623 | GDC-0623 (RG 7421) is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM). Uses: Scientific research. Category: Signaling pathways. Alternative Names: RG 7421; MEK inhibitor 1. CAS No. 1168091-68-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15610. | |
| GDC-0834 | GDC-0834 is an orally active selective, potent, and reversible BTK inhibitor with an IC50 of 5.9 nM. GDC-0834 demonstrates pBTK-Tyr223 inhibition in mice and rats. GDC-0834 can be used for research of rheumatoid arthritis (RA)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1133432-49-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15427. | |
| GDC-0879 | GDC-0879 is a potent and selective B-Raf inhibitor with an IC50 of 0.13 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 905281-76-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50864. | |
| GDC-2394 | GDC-2394 is an orally active and selective NLRP3 inhibitor, and also inhibits IL-1β with IC50s of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β). GDC-2394 inhibits NLRP3-induced caspase-1 activity without inhibiting NLRC4-dependent inflammasome activation. GDC-2394 could be used to study gouty arthritis. Uses: Scientific research. Category: Signaling pathways. CAS No. 2238822-07-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148258. | |
| GDC-2992 | GDC-2992 (Compound 28A) is an orally bioavailable androgen receptor (AR) PROTAC degrader. GDC-2992 degrads AR with a DC50 value of 2.7 nM and inhibits proliferation with an IC50 valude of 9.7 nM in VCaPcells. GDC-2992 can be used for prostatic cancer study. (Structure Note: Pink: target protein ligand (HY-130845); Blue: E3 ligase ligand (HY-W1003189A); Black: linker (HY-169975); E3 ligase ligand +linker (HY-169976A))[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RO7656594. CAS No. 2753651-10-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156751A. | |
| GDP366 | GDP366, a dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. Uses: Scientific research. Category: Signaling pathways. CAS No. 501698-03-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00177. | |
| GDP-α-D-mannose disodium | GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 148296-46-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N7389B. | |
| GDP-azido-fucose disodium | GDP-Azido-Fucose disodium is a chemically modified donor substrate. GDP-Azido-Fucose disodium can be used to synthesize fluorophore-conjugated GDP-fucose. GDP-Azido-Fucose can be used to study glycosyltransferase reactions[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 944560-34-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164169A. | |
| GDP-D-mannose disodium | GDP-D-mannose disodium consists of GDP-α-D-mannose (HY-N7389B) and GDP-β-D-mannose. GDP-α-D-mannose serves as a donor substrate for mannosyltransferases and acts as a precursor of GDP-β-L-fucose. GDP-α-D-mannose exerts competitive inhibition on GTP (with a Ki value of 14.7 μM) and non-competitive inhibition on mannose-1-P (with a Ki value of 115 μM). GDP-D-mannose disodium is metabolized to GDP-L-fucose (HY-134433) via GMDS (Gmd) and TSTA3 (WcaG)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 103301-73-1. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg. Product ID: HY-N7389A. | |
| GDP-L-fucose | GDP-L-fucose is a nucleotide sugar that is a key substrate for the biosynthesis of fucose oligosaccharides, providing the fucose moiety for the oligosaccharides.The formation of GDP-L-fucose occurs through two pathways, the major ab initio metabolic pathway and the minor remedial metabolic pathway. GDP-L-fucose is associated with diabetes in rats[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 15839-70-0. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134433. | |
| GDP-L-fucose disodium | GDP-L-fucose disodium is a nucleotide sugar that is a key substrate for the biosynthesis of fucose oligosaccharides. GDP-L-fucose disodium provides the fucose moiety for the oligosaccharides. The formation of GDP-L-fucose disodium occurs through two pathways, the major de novo metabolic pathway and the minor remedial metabolic pathway[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 148296-47-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-134433A. | |
| GE11 | GE11 is a active peptide and combines with colloidal drug delivery systems as smart carriers for antitumor drugs and can be used for cancer study[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 875142-25-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P10128. | |
| GE11, Cys Conjugated | GE11, Cys Conjugated is a peptide conjugate. GE11, Cys Conjugated consists of GE11 (HY-P10128) conjugated to a GGGGC sequence. GE11, Cys Conjugated can be used to synthesize stimulus-responsive peptide nanomaterials (SRPNs) for photoacoustic imaging and cancer research, such as studies on triple-negative breast cancer (TNBC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1259031-31-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P11051. | |
| Gedatolisib | Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC50s of 0.4 nM, 5.4 nM and 1.6 nM, respectively[1]. Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PKI-587; PF-05212384. CAS No. 1197160-78-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10681. | |
| Gedatolisib (Standard) | Gedatolisib (Standard) is the analytical standard of Gedatolisib. This product is intended for research and analytical applications. Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC50s of 0.4 nM, 5.4 nM and 1.6 nM, respectively[1]. Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1197160-78-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10681R. | |
| Gedivumab | Gedivumab (MHAA4549A; RG7745) is a human monoclonal antibody that targets influenza A virus (IAV) with high specificity and binds to the highly conserved stem region of the IAV haemagglutinin protein, thereby preventing haemagglutinin maturation and blocking haemagglutinin-mediated membrane fusion in the intranucleosome. Gedivumab can be used in IAV infection disease studies[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MHAA4549A; RG7745. CAS No. 1807954-17-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99637. | |
| Gefapixant | Gefapixant is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC50 values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant can be used for the research of chronic cough and knee osteoarthritis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-7264; AF-219. CAS No. 1015787-98-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101588. | |
| Gefapixant citrate | Gefapixant citrate is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC50 values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant citrate can be used for the research of chronic cough and knee osteoarthritis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-7264 citrate; AF-219 citrate. CAS No. 2310299-91-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101588A. | |
| Gefitinib | Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy and cell apoptosis, which can be used for cancer related research, such as Lung cancer and breast cancer [1][2][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ZD1839. CAS No. 184475-35-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-50895. | |
| Gefitinib-based PROTAC 3 | Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a von Hippel-Lindau ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2230821-27-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123921. | |
| Gefitinib-d3 | Gefitinib-d3 (ZD1839-d3) is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1173976-40-3. Pack Sizes: 1 mg. Product ID: HY-50895S2. | |
| Gefitinib hydrochloride | Gefitinib hydrochloride (ZD1839 hydrochloride) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib hydrochloride selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib hydrochloride also induces autophagy. Gefitinib hydrochloride has antitumour activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ZD-1839 hydrochloride. CAS No. 184475-55-6. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-50895A. | |
| Gefurulimab | Gefurulimab (ALXN-1720) is a high-affinity antibody inhibitor targeting complement protein C5, which can specifically bind to C5 and inhibit its cleavage into C5a and C5b. Gefurulimab can block the activation of the terminal complement pathway and reduce inflammatory damage. Gefurulimab can effectively reduce the formation of membrane attack complex (MAC) and has good pharmacokinetic properties. Gefurulimab can be used to study kidney and autoimmune diseases related to abnormal activation of the complement system, such as IgA nephropathy, lupus nephritis, and myasthenia gravis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALXN-1720. CAS No. 2456407-94-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99638. | |
| Gelatins | Gelatins is a non-toxic, non carcinogenic, biodegradable, and non irritating natural polymer derived from partial hydrolysis of collagen. Due to its strong liquid absorption and swelling ability, Gelatins has excellent hemostatic properties and can be used as a matrix material for the reduction, growth, and stability of metal nanoparticles. Gelatins can also be used for tumor cell culture and tumor therapy[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9000-70-8. Pack Sizes: 50 mg; 100 mg; 500 mg. Product ID: HY-Y1365. | |
| Geldanamycin | Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities. Uses: Scientific research. Category: Signaling pathways. CAS No. 30562-34-6. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15230. | |
| Geldanamycin-FITC | Geldanamycin-FITC, a Geldanamycin fluorescent probe, can be used in a fluorescence polarization assay for HSP90 inhibitors. Geldanamycin-FITC also can be used for detection of cell surface HSP90 (Ex/Em = 488/515 nm)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2969156-01-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-133705. | |
| Gellan gum, for cell culture | Gellan gum is a linear microbial exopolysaccharide that can be used as a cell scaffold for both soft tissue and load bearing applications. Gellan gum has many advantages such as biocompatibility, biodegradability, nontoxic in nature, and physical stability in the presence of cations[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Agar substitute gelling agent, for cell culture. CAS No. 71010-52-1. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-125870. | |
| GelMA, 60% methacrylation | GelMA (Gelatin Methacryloyl), 60% methacrylation, is a derivative obtained by the reaction of Methacrylic anhydride (MA) (HY-W017330) and gelatin. GelMA exhibits excellent biocompatibility, biodegradability, and moldability. GelMA can be photocrosslinked into hydrogels and can be used for research in regeneration of tissues, such as skin, tendon, bone, cartilage, blood vessel, and cardiovascular system. GelMA hydrogel also can be used for research on drug delivery, organ-on-a-chip, and biosensing[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Gelatin Methacryloyl, 60% methacrylation. CAS No. 2280018-77-9. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W763582A. | |
| GelMA, 90% methacrylation | GelMA (Gelatin Methacryloyl), 90% methacrylation, is a derivative obtained by the reaction of Methacrylic anhydride (MA) (HY-W017330) and gelatin. GelMA exhibits excellent biocompatibility, biodegradability, and moldability. GelMA can be photocrosslinked into hydrogels and can be used for research in regeneration of tissues, such as skin, tendon, bone, cartilage, blood vessel, and cardiovascular system. GelMA hydrogel also can be used for research on drug delivery, organ-on-a-chip, and biosensing[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Gelatin Methacryloyl, 90% methacrylation. CAS No. 2280018-77-9. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W763582B. | |
| Gelsemine | Gelsemine, an alkaloid from the Chinese herb Gelsemium elegans, is effective in mitigating chronic pain. Antinociceptive effects. Uses: Scientific research. Category: Natural products. CAS No. 509-15-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0388. | |
| Gelucire 44/14 | Gelucire 44/14 is a potential and safe absorption enhancer for improving the absorption of poorly absorbable agents including insulin and calcitonin by pulmonary delivery. Uses: Scientific research. Category: Signaling pathways. CAS No. 121548-04-7. Pack Sizes: 25 g; 50 g; 100 g. Product ID: HY-Y1892. | |
| GEM144 | GEM144 is a potent and orally active DNA polymerase α (POLA1) and HDAC 11 dual inhibitor. GEM144 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. GEM144 has significant antitumor activity in human orthotopic malignant pleural mesothelioma xenografts[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2487526-28-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143411. | |
| Gem-C12 | Gem-C12 is a prodrug of Gemcitabine (HY-17026). Gem-C12 terminates DNA chain elongation, inhibits nucleic acid synthesis and induces Apoptosis. Gem-C12 inhibits the proliferation of glioma cells. Gem-C12 and Honokiol (HY-N0003) exhibit synergistic anti-glioblastoma activity. Gem-C12 can be used in research related to glioblastoma multiforme[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 849139-19-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-185323. | |
| Gemcitabine | Gemcitabine (LY 188011) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, and can modulate autophagy. Gemcitabine induces apoptosis through the activation of p38 MAPK. Gemcitabine demonstrates efficacy in mouse models of pancreatic and breast cancer. Gemcitabine can be used for cancer research, such as pancreatic cancer, non-small cell lung cancer, and breast cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY 188011. CAS No. 95058-81-4. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-17026. | |
| Gemcitabine-13C,15N2 | antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY 188011-13C,15N2. CAS No. 1233921-74-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-17026S. | |
| Gemcitabine-13C,15N2 hydrochloride | Gemcitabine-13C,15N2 (hydrochloride) is the 13C and 15N labeled Gemcitabine hydrochloride[1]. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY 188011-13C,15N2 hydrochloride. CAS No. 2757566-59-7. Pack Sizes: 500 μg. Product ID: HY-B0003S. | |
| Gemcitabine hydrochloride | Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY 188011 hydrochloride. CAS No. 122111-03-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B0003. | |
| Gemcitabine hydrochloride (Standard) | Gemcitabine (hydrochloride) (Standard) is the analytical standard of Gemcitabine (hydrochloride). This product is intended for research and analytical applications. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY 188011 hydrochloride (Standard). CAS No. 122111-03-9. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0003R. | |
| Gemcitabine monophosphate | Gemcitabine monophosphate (Gemcitabine 5-phosphate) is one of the active intermediates of Gemcitabine (HY-17026). Gemcitabine monophosphate has a synergistic anti-cancer effect and can be delivered by formulating it into nanoparticles[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Gemcitabine 5-phosphate. CAS No. 116371-67-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108932. | |
| Gemcitabine-O-Si(di-iso)-O-Mc | Gemcitabine-O-Si(di-iso)-O-Mc is a agent-linker conjugate for ADC with potent antitumor activity by using Gemcitabine (a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent; HY-17026), linked via the ADC linker[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3109709-80-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-130812. | |
| Gemcitabine (Standard) | Gemcitabine (Standard) is the analytical standard of Gemcitabine. This product is intended for research and analytical applications. Gemcitabine (LY 188011) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY 188011 (Standard). CAS No. 95058-81-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17026R. | |
| Gemfibrozil | Gemfibrozil is an activator of PPAR-α, used as a lipid-lowering agent; Gemfibrozil is also a nonselective inhibitor of several P450 isoforms, with Ki values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CI-719. CAS No. 25812-30-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B0258. | |
| Gemfibrozil 1-O-β-glucuronide | Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 91683-38-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129993. | |
| Gemifloxacin mesylate | Gemifloxacin mesylate (SB-265805S; LB-20304a) is an orally active broad-spectrum quinolone antibacterial antibiotic. Gemifloxacin mesylate inhibits DNA synthesis by inhibiting DNA gyrase and Topoisomerase IV activities. Gemifloxacin mesylate has potent antibacterial activities against gram-positive bacteria in vitro efficacy study, particularly Streptococci and Staphylococci. Gemifloxacin mesylate has been used in the research of respiratory tract infections[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SB-265805S; LB-20304a. CAS No. 210353-53-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B1050. | |
| Gemilukast | Gemilukast is an orally active and potent dual cysteinyl leukotriene 1 and 2 receptors (CysLT1 and CysLT2) antagonist, with IC50s of 1.7, 25 nM for human CysLT1 and CysLT2, respectively. Gemilukast is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ONO-6950. CAS No. 1232861-58-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16780. | |
| Gemtuzumab | Gemtuzumab is a monoclonal IgG4-κ antibody targeting CD33 antigen. Gemtuzumab affects cell necrosis by specifically targeting CD33 expressed on the surface of leukaemic cell blasts in acute myeloid leukemia (AML). Gemtuzumab can be used for synthesis of antibody-drug conjugate (ADC), Gemtuzumab ozogamicin (HY-109539). Gemtuzumab ozogamicin consists of a cytotoxic derivative of Calicheamicin (a cytotoxic antibiotic), and a monoclonal antibody. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2924764-21-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P99971. | |
| Gemtuzumab ozogamicin | Gemtuzumab ozogamicin is an antibody-drug conjugate (ADC) consisting of a humanized immunoglobulin (IgG4) antibody directed against CD33 that is conjugated to the cytotoxic agent Calicheamicin (HY-19609). The antibody portion is Gemtuzumab (HY-P99971), and the drug-linker conjugate for ADC is N-Ac-γ-Calicheamicin-AcBut-NHS ester (HY-103688). Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia (AML)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 220578-59-6. Pack Sizes: 100 μg; 200 μg; 500 μg. Product ID: HY-109539. | |
| Genevant CL1 | Genevant CL1 is an ionizable lipid (pKa = 6.3) suitable for the preparation of lipid nanoparticles (LNPs) for delivering nucleic acid payloads and intramuscular vaccines. Genevant CL1 is a component of lipid nanoparticle delivery systems for mRNA vaccines[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1450888-71-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-46759. | |
| Genipin | Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Genipin. CAS No. 6902-77-8. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-17389. | |
| Genipin (Standard) | Genipin (Standard) is the analytical standard of Genipin. This product is intended for research and analytical applications. Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Genipin (Standard). CAS No. 6902-77-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17389R. | |
| Geniposidic acid | Geniposidic acid is an orally active FXR modulator and SIRT6 activator. Geniposidic acid binds to the Ser332 and His447 sites on the FXR ligand-binding domain, thereby driving nuclear translocation, coactivator recruitment, and transcription of downstream bile acid and cholesterol metabolism-related genes. Geniposidic acid improves metabolic dysfunction-related fatty liver disease by activating the SIRT6 signaling pathway. Geniposidic acid inhibits inflammation and modulates gut microbiota to alleviate colitis. Geniposidic acid can be used in research on drug-induced liver injury, inflammatory bowel disease, metabolic dysfunction-related fatty liver disease, and metabolic dysfunction-related steatohepatitis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 27741-01-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-N0010. | |
| Geniposidic acid (Standard) | Geniposidic acid (Standard) is the analytical standard of Geniposidic acid. This product is intended for research and analytical applications. Geniposidic acid has radiation protection and anti-cancer activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 27741-01-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0010R. | |
| Genistein | Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NPI 031L. CAS No. 446-72-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g. Product ID: HY-14596. | |
| Genistein 7-β-D-Glucuronide | Genistein 7-β-D-Glucuronide (Genistein 7-O-glucuronide) is the primary phase II metabolite of Genistein (HY-14596) in human and rat hepatocytes. Genistein 7-β-D-Glucuronide undergoes distinct deconjugation in different functional assays. Genistein 7-β-D-Glucuronide is produced via hepatic microsomal glucuronidation and shows a mild age-related increase in intrinsic clearance in male F344 rats. Genistein 7-β-D-Glucuronide can be used for research on metabolism[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Genistein 7-O-glucuronide. CAS No. 38482-81-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-137967. | |
| Genistein-d4 | Genistein-d4 is the deuterium labeled Genistein. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NPI 031L-d4. CAS No. 187960-08-3. Pack Sizes: 1 mg. Product ID: HY-14596S. | |
| Genistein (Standard) | Genistein (Standard) is the analytical standard of Genistein. This product is intended for research and analytical applications. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NPI 031L (Standard). CAS No. 446-72-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14596R. | |
| Genistin | Genistin (Genistine), an isoflavone belonging to the phytoestrogen family, is a potent anti-adipogenic and anti-lipogenic agent. Genistin attenuates cellular growth and promotes apoptotic cell death breast cancer cells through modulation of ERalpha signaling pathway[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Genistine; Genistoside; Genistein 7-O-β-D-glucopyranoside. CAS No. 529-59-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-N0595. | |
| Genkwanin | Genkwanin is a major non-glycosylated flavonoid with anti-flammatory activities. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Puddumetin. CAS No. 437-64-9. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0731. | |
| Gentamicin | Gentamicin, an aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin inhibits DNase I with an IC50 of 0.57 mM[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1403-66-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0276A. | |
| Gentamicin C1a | Gentamicin C1a is the precursor of the semi-synthetic antibiotic Etimicin, and has antibacterial activity. Gentamicin C1a is the major component of the Gentamicin complex[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 26098-04-4. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148286. | |
| Gentamicin sulfate | Gentamicin sulfate, an aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin sulfate inhibits DNase I with an IC50 of 0.57 mM[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1405-41-0. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-A0276. | |
| Gentiopicroside | Gentiopicroside, a naturally occurring iridoid glycoside, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22.8 μM for CYP2A6; Gentiopicroside has anti-inflammatoryand antioxidative effects. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Gentiopicrin. CAS No. 20831-76-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0494. | |
| Gentisin | Gentisin is a natural compound. Gentisin can be extracted from Gentianae radix (Gentianaceae). Gentisin has mutagenic activity. Gentisin can be used in vascular smooth muscle research[1][2]. Uses: Scientific research. Category: Natural products. CAS No. 437-50-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N4279. | |
| Genz-123346 | Genz-123346 is a potent, orally available glucosylceramide synthase inhibitor. Genz-123346 blocks the conversion of ceramide to glucosylceramide (GL1) and inhibits GM1 with an IC50 value of 14 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 943344-58-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12744A. | |
| Genz-123346 free base | Genz-123346 free base is an orally available inhibitor of glucosylceramide synthase. Genz-123346 blocks the conversion of ceramide to glucosylceramide (GL1) and inhibits GM1 with an IC50 of 14 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 491833-30-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-12744. | |
| Gepirone | Gepirone is a selective and affinitive 5-HT1A agonist. Gepirone binds selectively to 5-HT1A receptor binding site. Gepirone acts as an antidepressant agent can be used for anxiety and major depressive disorder research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 83928-76-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122422. | |
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