MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Gamma-Linolenic acid | Gamma-linolenic acid (γ-Linolenic acid) is an orally active unsaturated fatty acid. Gamma-linolenic acid exerts anti-inflammatory effects by inhibiting the NF-κB pathway and the phosphorylation of ERK1/2 and JNK. At the same time, it exerts anticancer effects by inducing apoptosis (Apoptosis) in cancer cells. Additionally, Gamma-linolenic acid also has antioxidant and memory-improving effects. It holds promise for research in the fields of inflammation, neurology, and cancer diseases[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: γ-Linolenic acid. CAS No. 506-26-3. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-N7140. |  |
| γ-Lumicolchicine | γ-Lumicolchicine is an inactive analogue of Colchicine (HY-16569) that can be used as an experimental control for Colchicine action[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6901-14-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-124479A. | |
| Gamma-Mangostin | Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer[2]. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: γ-Mangostin. CAS No. 31271-07-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N1957. | |
| γ-Sanshool | γ-Sanshool can be isolated from Zanthoxylum piperitum. γ-Sanshool inhibits human ACAT-1 and ACAT-2 activities with IC50s of 12.0 and 82.6 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 78886-65-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-111880. | |
| gamma-secretase modulator 6 | gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. gamma-secretase modulator 6 inhibits Aβ42 secretion in HEK cell line stably expressing APP (Aβ amyloid precursor protein) (pIC50: 8.1). gamma-secretase modulator 6 can be used for research of Alzheimer's disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1255700-88-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-171347. | |
| γ-Tocopherol | γ-Tocopherol (D-γ-Tocopherol) is a potent cyclooxygenase (COX) inhibitor. γ-Tocopherol is a naturally occurring form of Vitamin E in many plant seeds, such as corn oil and soybeans. γ-Tocopherol possesses antiinflammatory properties and anti-cancer activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-γ-Tocopherol; (+)-γ-Tocopherol. CAS No. 54-28-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N7148. | |
| γ-Tocopherol (Standard) | γ-Tocopherol (Standard) is the analytical standard of γ-Tocopherol. This product is intended for research and analytical applications. γ-Tocopherol (D-γ-Tocopherol) is a potent cyclooxygenase (COX) inhibitor. γ-Tocopherol is a naturally occurring form of Vitamin E in many plant seeds, such as corn oil and soybeans. γ-Tocopherol possesses antiinflammatory properties and anti-cancer activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-γ-Tocopherol (Standard); (+)-γ-Tocopherol (Standard). CAS No. 54-28-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N7148R. | |
| γ-Tocotrienol | γ-Tocotrienol is an active form of vitamin E. γ-tocotrienol reverses the multidrug resistance (MDR) of breast cancer cells through the signaling pathway of NF-κB and P-gp. γ-Tocotrienol is also a radioprotector agent, can mitigate bone marrow radiation damage during targeted radionuclide treatment[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 14101-61-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108694. | |
| Ganciclovir | Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BW 759; 2'-Nor-2'-deoxyguanosine. CAS No. 82410-32-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 1 g; 5 g. Product ID: HY-13637. | |
| Ganciclovir-d5 | Ganciclovir-d5 is the deuterium labeled Ganciclovir. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BW 759-d5; 2'-Nor-2'-deoxyguanosine-d5. CAS No. 1189966-73-1. Pack Sizes: 1 mg. Product ID: HY-13637S. | |
| Ganciclovir sodium | Ganciclovir (BW 759) sodium, a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir sodium also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir sodium inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir sodium has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BW 759 sodium; 2'-Nor-2'-deoxyguanosine sodium. CAS No. 107910-75-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 1 g. Product ID: HY-13637A. | |
| Ganciclovir (Standard) | Ganciclovir (Standard) is the analytical standard of Ganciclovir. This product is intended for research and analytical applications. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BW 759 (Standard); 2'-Nor-2'-deoxyguanosine (Standard). CAS No. 82410-32-0. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13637R. | |
| Gancotamab antibody | Gancotamab antibody (MM-302) is a HER2-targeted antibody with antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MM-302 antibody. CAS No. 1509928-00-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99630. | |
| Gandotinib | Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC50 of 3 nM. Gandotinib (LY2784544) also inhibits FLT3, FLT4, FGFR2, TYK2, and TRKB with IC50 of 4, 25, 32, 44, and 95 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY2784544. CAS No. 1229236-86-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13034. | |
| Ganetespib | Ganetespib (STA-9090) is a heat shock protein 90 (HSP90) inhibitor which exhibits potent cytotoxicity in a wide variety of hematological and solid tumor cell lines. Ganetespib has antiangiogenic effects in colorectal cancer mediated through inhibition of HIF-1α and STAT3[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: STA-9090. CAS No. 888216-25-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-15205. | |
| Ganfeborole hydrochloride | Ganfeborole hydrochloride (GSK656) is a potent antitubercular agent, acting as an inhibitor of Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (LeuRS), with an IC50 of 0.2 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSK656; GSK3036656; GSK070. CAS No. 2131798-13-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107775. | |
| Ganglioside GD3 diammonium | Ganglioside GD3 diammonium is an acidic glycosphingolipid. Ganglioside GD3 diammonium inhibits the proliferation of cancer cells, affects the opening of the mitochondrial permeability transition pore (PTPC), induces apoptosis and activates caspase family. Ganglioside GD3 diammonium can be used in research about cancer and neurodegenerative diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1246353-20-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-131139A. | |
| Ganglioside GM1 | Ganglioside GM1 is a type of glycosphingolipid, mainly found on the cell membranes of the central nervous system of vertebrates. Ganglioside GM1 exerts neuroprotective effects by reducing excessive activation of NMDAR, activating TrkA and ERK1/2, and inhibiting oxidative stress and cell apoptosis and autophagy. Ganglioside GM1 can be used in the research of diseases such as traumatic brain injury, Parkinson's disease, Alzheimer's disease, and Huntington's disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 37758-47-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N10546. | |
| Ganglioside GM1 (bovine) ammonium | Ganglioside GM1 (bovine) ammonium is a type of glycosphingolipid, mainly found on the cell membranes of the central nervous system of vertebrates. Ganglioside GM1 (bovine) ammonium exerts neuroprotective effects by reducing excessive activation of NMDAR, activating TrkA and ERK1/2, and inhibiting oxidative stress and cell apoptosis and autophagy. Ganglioside GM1 (bovine) ammonium can be used in the research of diseases such as traumatic brain injury, Parkinson's disease, Alzheimer's disease, and Huntington's disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1007119-81-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N10546A. | |
| Ganglioside GM2 | Ganglioside GM2 is a human tumor antigen predominantly found in human tumor cells and fetal brain tissue. As a sialylated glycosphingolipid, Ganglioside GM2 is involved in processes such as cell signaling, adhesion, and motility. Ganglioside GM2 abnormal expression and accumulation are associated with tumors and neurodegenerative disorders. Ganglioside GM2 promotes tumor cell migration and invasion by directly binding to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, and inducing actin cytoskeleton remodeling[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 127663-77-8. Pack Sizes: 1 mg. Product ID: HY-148385. | |
| Ganglioside GM3 | Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 124579-05-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-114456. | |
| Ganglioside GT1b (bovine) ammonium | Ganglioside GT1b (bovine) ammonium is a member of the ganglioside family. Ganglioside GT1b (bovine) ammonium acts as a protective signal against nerve injury-induced spinal synapse elimination. Ganglioside GT1b (bovine) ammonium induces HA synthesis and the phosphorylation of Akt/mTOR in orbital fibroblasts. Ganglioside GT1b (bovine) ammonium enhances porcine oocyte maturation and induce activation of EGFR and ERK1/2 signaling. Ganglioside GT1b (bovine) ammonium is a putative host cell receptor for the Merkel cell polyomavirus. Ganglioside GT1b (bovine) ammonium can be used for the researches of cancer, infection, immunology, endocrinology and neurological disease, such as Thyroid eye disease[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 59247-13-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-131686. | |
| Ganitumab | Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMG 479; Human Anti-IGF1R Recombinant Antibody. CAS No. 905703-97-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99294. | |
| Ganoderic acid A | Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS. Uses: Scientific research. Category: Signaling pathways. CAS No. 81907-62-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N1447. | |
| Ganoderic acid B | Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC50: 170 μM)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 81907-61-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N2006. | |
| Ganoderic acid C2 | Ganoderic acid C2 is a bioactive triterpenoid in Ganoderma lucidum. Ganoderic acid C2 possesses the potential anti-tumor bioactivity, antihistamine, anti-aging and cytotoxic effects. Ganoderic acid C2 is the inhibitor for aldose reductase with an IC50 of 43.8 μM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 103773-62-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N1517. | |
| Ganoderic acid D | Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1]. Ganoderic acid D induces HeLa human cervical carcinoma apoptosis[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 108340-60-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N1511. | |
| GANT 61 | GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC 136476. CAS No. 500579-04-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13901. | |
| Gantenerumab | Gantenerumab is a fully humanized anti-Aβ IgG1 monoclonal antibody. Gantenerumab can specifically bind to Aβ fibrils and plaques and can be used in Alzheimer's disease research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R-04909832; RG-1450. CAS No. 1043556-46-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99022. | |
| Gap19 | Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1507930-57-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P1136. | |
| Gap 26 | Gap 26 is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 197250-15-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P1082. | |
| Gap 27 | Gap 27, a synthetic connexin43 mimetic peptide, is a gap junction inhibitor. Gap 27 possesses conserved sequence homology to a portion of the second extracellular loop leading into the fourth transmembrane connexin segment[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 198284-64-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P0139. | |
| GAPDH, rabbit muscle | Glyceraldehyde phosphate dehydrogenase (EC 1.2.1.12) is the target of anti-thymocyte and anti-apoptotic agents. Glyceraldehyde phosphate dehydrogenase catalyzes the chain oxidation of reduced nicotinamide adenine dinucleotide by perhydroxyl radicals[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GADPH; G3PDH; Glyceraldehyde phosphate dehydrogenase. CAS No. 9001-50-7. Pack Sizes: 100 U; 500 U. Product ID: HY-P2804. | |
| Garadacimab | Garadacimab (CSL312) is a first-in-class, fully human IgG4 monoclonal antibody targeting activated factor XII (FXIIa). Garadacimab has the potential for hereditary angioedema research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CSL312. CAS No. 2162134-62-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99631. | |
| Garbanzol | Garbanzol is an orally active natural flavonoid compound. Garbanzol is one of the key intermediates in the flavonoid biosynthetic pathway. Garbanzol exhibits anti-mutagenic activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1226-22-8. Pack Sizes: 1 mg. Product ID: HY-N3926. | |
| Garcinia cambogia extract | Garcinia cambogia extract is an orally active anti-obesity agent[1]. Garcinia cambogia extract upregulates the gene expression of aP2, SREBP1c, PPARγ2 and C/EBPα. Garcinia cambogia extract reduces the rate of body weight gain, visceral fat accumulation, lipid levels in blood and liver, as well as plasma insulin and leptin levels[1][2]. Garcinia cambogia extract ameliorates high-fat diet-induced obesity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 90045-23-1. Pack Sizes: 50 mg; 100 mg; 1 g; 5 g. Product ID: HY-N14035. | |
| Garcinol | Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively[1]. Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 78824-30-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-107569. | |
| Garcinone D | Garcinone D is an activator of the STAT3/Cyclin D1 and Nrf2/HO-1 pathways, and an inhibitor of CDK2/CyclinE1 (IC50 for CDK2/CyclinE1 is 28.23 μM). Garcinone D promotes neural stem cell proliferation by activating STAT3 phosphorylation and Cyclin D1 expression and enhancing the Nrf2/HO-1 signaling pathway. In addition, Garcinone D blocks the tumor cell cycle by inhibiting CDK2/CyclinE1. Garcinone D can promote the proliferation of C17.2 neural stem cells and inhibit prostate and breast cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 107390-08-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N6953. | |
| Garcinone E | Garcinone E is a natural xanthone found in the rind of the mangosteen fruit. Garcinone E induces apoptosis and inhibits cancer cell migration. Garcinone E has anticancer effects on different human cancer cell lines, including colorectal, breast, and hepatocellular carcinomas[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 112649-21-5. Pack Sizes: 1 mg. Product ID: HY-123901. | |
| Gardenin B | Gardenin B is a methoxyflavone compound and an inhibitor of USP7, ODC (IC50: 6.24 μg/mL), and Cathepsin D (IC50: 5.61 μg/mL). Gardenin B exhibits antioxidant and antitumor activities. Gardenin B shows IC50 values of 8.87 and 10.59 μg/mL for DPPH and NO scavenging, respectively, and also possesses ferric ion reducing ability. Additionally, Gardenin B can inhibit tumor cell proliferation, induce cell cycle arrest and apoptosis. Gardenin B can be used in cancer research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2798-20-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N6037. | |
| Gardiquimod | Gardiquimod is an imidazoline TLR7/8 agonist. Gardiquimod inhibits HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod specifically activates TLR7 at concentrations below 10 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1020412-43-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103697. | |
| Gardiquimod diTFA | Gardiquimod diTFA is an imidazoline TLR7/8 agonist. Gardiquimod diTFA inhibits HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod diTFA specifically activates TLR7 at concentrations below 10 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1159840-61-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103697A. | |
| Garetosmab | Garetosmab (REGN 2477) is a fully human IgG4 monoclonal antibody that specifically inhibits activin A. Garetosmab can be used for fibrodysplasia ossificans progressiva (FOP) research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: REGN 2477. CAS No. 2097125-54-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P99632. | |
| Gartisertib | Gartisertib (VX-803) is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM. Gartisertib potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation with an IC50 of 8 nM. Antitumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VX-803; M4344; ATR inhibitor 2. CAS No. 1613191-99-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136270. | |
| Gastric Inhibitory Peptide, porcine | Gastric Inhibitory Peptide (GIP (1-42)), porcine is a porcine glucose-dependent insulinotropic polypeptide and inhibitor of pentagastrin-stimulated gastric acid secretion. Gastric Inhibitory Peptide, porcine stimulates endogenous somatostatin release. Gastric Inhibitory Peptide, porcine acts in a dose- and time-dependent manner in conscious, chronic gastric fistula-equipped rats[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GIP (1-42), porcine. CAS No. 11063-17-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3579. | |
| Gastric mucin | Gastric mucin is a glycoprotein with natural antibiotic function. Gastric mucin against Helicobacter pylori infection. Gastric mucin effectively scavenges hydroxyl radical. Gastric mucin play a major role in the protection of the gastrointestinal tract from acid, proteases, pathogenic microorganisms, and mechanical trauma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 84082-64-4. Pack Sizes: 500 mg; 10 g. Product ID: HY-B2196. | |
| Gastrin I (1-14), human | Gastrin I (1-14), human is 1-14 fragment of human gastrin I peptide. Gastrin I is an endogenous, gastrointestinal peptide hormone. Gastrin is the major hormonal regulator of gastric acid secretion[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 100940-57-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1806. | |
| Gastrin I, human | Gastrin I, human is the endogenous peptide produced in the stomach, and increases gastric acid secretion via cholecystokinin 2 (CCK2) receptor. Uses: Scientific research. Category: Signaling pathways. CAS No. 10047-33-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1097. | |
| Gastrin I (human) sulfated | Gastrin I (human) (sulfated) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development[1]. Uses: Scientific research. Category: Peptides. CAS No. 19361-51-4. Pack Sizes: 100 μg; 500 μg; 1 mg; 5 mg. Product ID: HY-P5055. | |
| Gastrin-Releasing Peptide, human | Gastrin-Releasing Peptide, human (GRP) belongs to the bombesin-like peptide family, and is not a classical hypothalamic-hypophyseal regulatory hormone since it plays only a perfunctory role in the mediation of pituitary hormone release. Uses: Scientific research. Category: Signaling pathways. CAS No. 93755-85-2. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-P0238. | |
| Gatifloxacin | Gatifloxacin (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic that can cross the blood-brain barrier, with broad-spectrum antibacterial activity. Gatifloxacin inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50=0.109 μg/ml)[1]. Gatifloxacin can be used to treat bacterial conjunctivitis in vivo. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AM-1155; BMS-206584; PD135432. CAS No. 112811-59-3. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-10581. | |
| Gatipotuzumab | Gatipotuzumab (PankoMab) is a humanized monoclonal antibody which recognizes the tumor-specific epitope of mucin-1 (TA-MUC1). Gatipotuzumab reveals a potent tumor-specific antibody-dependent cell cytotoxicity (ADCC)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PankoMab; DS-3939a antibody. CAS No. 1264737-26-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99634. | |
| GB1107 | GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3. GB1107 reduces human and mouse lung adenocarcinoma growth and blocks metastasis in the syngeneic model[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1978336-61-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114409. | |
| GB1908 | GB1908 is a selective and orally active galectin-1 inhibitor with Ki values of 57 nM and 72 nM for human and mouse galectin-1, respectively. GB1908 displays >50-fold selectivity over galectin-3. GB1908 can be used for the study of lung cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2573135-31-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-162561. | |
| GB83 | GB83 is a potent PAR2 antagonist. GB83 reverses neutrophil elastase?induced synovitis and pain. GB83 blocks the effect of MET-1 supernatant on NG neurons[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1252806-86-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-124061. | |
| GB-88 | GB-88 is an oral, selective non-peptide antagonist of PAR2, inhibits PAR2 activated Ca2+ release with an IC50 of 2 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1416435-96-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120261. | |
| GBD-9 | GBD-9 is a degrader based on the E3 ubiquitin ligase CRBN that targets BTK and the G1 to S phase transition protein GSPT1. GBD-9 has both PROTAC and molecular glue properties by inducing ubiquitination and proteasomal degradation of target proteins. GBD-9 can efficiently degrade wild-type and mutant BTK (such as C481S mutation) and GSPT1. GBD-9 significantly inhibits tumor cell proliferation by inducing G1 phase arrest in cancer cells, downregulating anti-apoptotic proteins (BCL-2, MCL-1) and activating Caspase-3 to induce apoptosis. GBD-9 is mainly used in the research of hematological tumors such as diffuse large B-cell lymphoma (DLBCL) and acute myeloid leukemia (AML)[1][2][3].GBD-9 is composed of E3 ubiquitin ligase ligand (pink part) 5-Aminothalidomide (HY-W023573), target protein ligand (blue part) Btk Inhibitor: IBT6A (HY-13036A), and PROTAC linker (black part) Nonanoic acid (HY-N7057). Uses: Scientific research. Category: Signaling pathways. CAS No. 2864408-92-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153803. | |
| Gboxin | Gboxin is an oxidative phosphorylation (OXPHOS) inhibitor that targets glioblastoma. Gboxin inhibits the activity of F0F1 ATP synthase. Antitumour activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2101315-36-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111651. | |
| GBR 12783 dihydrochloride | GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 67469-75-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-100968. | |
| GC376 sodium | GC376 sodium is a 3CLpro inhibitor; inhibits the replication of viruses TGEV, FIPV and PTV with IC50 values of 0.15, 0.2 and 0.15 μM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1416992-39-6. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-100721. | |
| GC7 Sulfate | GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 150417-90-6. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108314A. | |
| Gcase activator 2 | Gcase activator 2 (compound 14), a pyrrolo[2,3-b]pyrazine, is alos a β-Glucocerebrosidase (GCase) activator (EC50=3.8 μM). Gcase activator 2 induces GCase dimerizatio (both K-type and V-type). And Gcase activator 2 has low metabolic clearance in human and mouse[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2759897-35-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-154823. | |
| Gcase activator 3 | Gcase activator 3 (compound 9Q) is a glucosidase (Glucosidase, GCase) activator that can partially stabilize GCase and increase its activity. Gcase activator 3 reduces mutant GCase protein misfolding and degradation in fibroblasts and dopaminergic midbrain neurons. Gcase activator 3 can be used in the study of Parkinson's disease (PD) and related synucleinopathies[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2270984-21-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-160426. | |
| GCN2 activator-1 | GCN2 activator-1 (Compound 20) is a GCN2 activator. GCN2 activator-1 binds within the ATP-pocket of GCN2 and activates GCN2 in a GCN1-independent manner. GCN2 activator-1 activates Integrated Stress Response (ISR) in cells. GCN2 activator-1 inhibits PKR with an IC50 of 3.75 μM. GCN2 activator-1 can be used for research of pulmonary veno-occlusive disease (PVOD)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 315705-10-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W319647. | |
| GCN2iB | GCN2iB is an ATP-competitive, selective GCN2 inhibitor with an IC50 of 2.4 nM. GCN2iB inhibits the activation of the GCN2 pathway and upregulates GPX4. GCN2iB enhances the anticancer effect of ASNase against acute lymphoblastic leukemia. GCN2iB increases left ventricular ejection fraction, while reducing fasting blood glucose and myocardial fibrosis. GCN2iB can be used in research related to acute lymphoblastic leukemia, acute myeloid leukemia and diabetic cardiomyopathy[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2183470-12-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112654. | |
| GCN2-IN-1 | GCN2-IN-1 is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with an IC50 of <0.3 μM in the enzyme assay and an IC50 of 0.3-3 μM in the cell assay[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1448693-69-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-100877. | |
| GCN2-IN-6 | GCN2-IN-6 (Compound 6d) is a potent, and orally available GCN2 inhibitor confirmed by in-house enzymatic (IC50 of 1.8 nM) and cellular assays (IC50 of 9.3 nM). GCN2-IN-6 is also a eIF2α kinase PERK inhibitor with an IC50 of 0.26 nM (in enzymatic assay) and 230 nM (in cells)[1]. GCN2-IN-6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2183470-09-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-130240. | |
| GCN2-IN-7 | GCN2-IN-7 (compound 39) is an orally active and selective general control nonderepressible 2 (GCN2) inhibitor (IC50=5 nM). GCN2-IN-7 shows anti-tumor activity in vivo[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2396465-33-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151460. | |
| GDC-0152 | GDC-0152 is a potent IAPs inhibitor, and binds to the BIR3 domains of XIAP, cIAP1, cIAP2 and the BIR domain of ML-IAP with Ki values of 28 nM, 17 nM, 43 nM and 14 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 873652-48-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13638. | |
| GDC-0276 | GDC-0276 is a potent, selective, reversible and orally active NaV1.7 inhibitor with an IC50 value of 0.4 nM. GDC-0276 is well tolerated and exhibits a good pharmacokinetic profile. GDC-0276 has the potential for the treatment of pain and to address shortcomings of existing pain medications, such as addiction and off-target side effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1494581-70-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114237. | |
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