MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| LN5P45 | LN5P45 is an OTUB2 inhibitor (IC50: 2.3 μM). LN5P45 induces monoubiquitination of OTUB2 on lysine 31. LN5P45 can be used for research of tumor progression and metastasis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3084190-39-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149482. |  |
| L-NAME hydrochloride | L-NAME hydrochloride inhibits NOS with an IC50 of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC50 value of 1.4 μM. L-NAME hydrochloride requires hydrolysis of the methyl ester by cellular esterases to become a fully functional inhibitor. L-NAME hydrochloride can be used to induce hypertension and preeclampsia models. Uses: Scientific research. Category: Induced disease models products. Alternative Names: NG-Nitroarginine methyl ester hydrochloride. CAS No. 51298-62-5. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-18729A. | |
| L-NIL | L-NIL is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 53774-63-3. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg. Product ID: HY-12116. | |
| L-NIO dihydrochloride | L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively[1][2]. L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 159190-44-0. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100986. | |
| L-NMMA acetate | L-NMMA (Tilarginine) acetate is a non-selective and competitive inhibitor of nitric oxide synthase. L-NMMA acetate inhibits three subtypes, namely nNOS, eNOS, and iNOS, and reduces NO production. L-NMMA acetate alleviates mechanical allodynia, thermal hyperalgesia, and choroidal fibrosis. L-NMMA acetate is applicable to research related to nociception, bone cancer pain, and myopia[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tilarginine acetate; Methylarginine acetate. CAS No. 53308-83-1. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18732A. | |
| L-Norleucine (Standard) | L-Norleucine (Standard) is the analytical standard of L-Norleucine. This product is intended for research and analytical applications. L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (S)-2-Aminohexanoic acid (Standard); (S)-Norleucine (Standard). CAS No. 327-57-1. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-Y0017R. | |
| LNP Lipid-3 | LNP Lipid-3 is an ionizable lipid that can be used to synthesize lipid nanoparticles. LNP Lipid-3 can be applied in the research of drug delivery[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2648693-32-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-153186. | |
| LNP Lipid-8 | LNP Lipid-8 (11-A-M) is an ionizable single-tail multi-head lipid that can be used as a lipid nanoparticle (LNP) to deliver siRNA to T cells without targeting ligands. LNP Lipid-8 is more selective for T cells than other cell types such as hepatocytes. LNP Lipid-8 selectively delivers siRNA/sgRNA to T cells (especially CD8+ T cells) through endogenous lipid transport pathways, and can enter cells and release RNA through endocytosis to achieve gene silencing. LNP Lipid-8 loaded with GFP siRNA (siGFP) significantly led to GFP gene silencing in mouse models. LNP Lipid-8 showed good efficacy and safety in both cells and animals, without obvious liver targeting and toxicity. LNP Lipid-8 can be used for RNA delivery research in the fields of tumor immunotherapy and T cell-mediated autoimmune diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2408140-60-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-154974. | |
| Lobeglitazone | Lobeglitazone is a new type of thiazolidinedione. Lobeglitazone is the orally active agonist for PPAR with EC50 of 137.4 nM and 546.3 nM for PPARγ and PPARα. Lobeglitazone is the inhibitor for ERK/JNK/Smad/NF-κB signaling pathway. Lobeglitazone exhibits anti-inflammatory, anti-diabetic, anti-fibrotic and anti-atherosclerotic properties[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 607723-33-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14928. | |
| Lobradimil | Lobradimil (RMP 7), a synthetic bradykinin analog, is a potent and selective bradykinin B2 receptor agonist (Ki: 0.54 nM). Lobradimil increases the permeability of the BBB. Lobradimil can be used in the research of brain tumors[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RMP 7. CAS No. 159768-75-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-105155. | |
| LOC14 | LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC50 and Kd values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding[1].LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 877963-94-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100432. | |
| L-Octanoylcarnitine | L-Octanoylcarnitine is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine can be used for the research of breast cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 25243-95-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113161. | |
| L-Octanoylcarnitine hydrochloride | L-Octanoylcarnitine hydrochloride is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine hydrochloride can be used for the research of breast cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 54377-02-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W354498. | |
| Lofexidine hydrochloride | Lofexidine hydrochloride (Baq-168) is an orally active agonist of the imidazoline I1 receptor (imidazoline I1 receptor) (Ki: 1.9 nM) and α2-adrenergic receptor (α2-adrenergic receptor). Lofexidine hydrochloride binds to the α2A-adrenergic receptor, reduces sympathetic outflow, lowers blood pressure, and exhibits vasoconstrictive effects. Lofexidine hydrochloride regulates the expression of c-fos and alleviates opioid withdrawal symptoms. Lofexidine hydrochloride is applicable to research on opioid addiction and withdrawal[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Baq-168; MDL-14042. CAS No. 21498-08-8. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-B1052. | |
| Loganic acid | Loganic acid is an iridoid isolated from cornelian cherry fruits. Loganic acid inhibits NF-κB signaling pathway, activates Nrf2 signaling pathway, exhibits anti-inflammatory activity. Loganic acid can modulate diet-induced atherosclerosis and redox status. Loganic acid has strong free radical scavenging activity and remarkable cyto-protective effect against heavy metal mediated toxicity. Loganic acid is orally active[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 22255-40-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0513. | |
| Loganin | Loganin is a type of iridoid glycoside compound that possesses anti-inflammatory, antioxidant, and antitumor properties, and offers protective effects against acute lung injury and pulmonary fibrosis. Loganin exerts its protective effects against LPS (HY-D1056)-mediated inflammation and oxidative stress by upregulating the Nrf2/HO-1 signaling pathway, and it reduces neuroinflammation caused by spinal cord injury (SCI)[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Loganoside. CAS No. 18524-94-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0512. | |
| Lokivetmab | Lokivetmab (Anti-Canine IL31 Recombinant Antibody) is an anti-canine IL-31 monoclonal antibody. Lokivetmab inhibits IL-31-mediated activation of pruritogenic signals in peripheral sensory neurons and reduces TH2-weighted inflammation. Lokivetmab demonstrates long-term efficacy in controlling pruritus and improving skin lesions in dogs with canine atopic dermatitis (CAD). Lokivetmab can be used for the research of atopic dermatitis (AD) in dogs[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Anti-Canine IL31 Recombinant Antibody; CAN34D3-65; PF-06443537. CAS No. 1533403-95-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99301. | |
| Loliolide | Loliolide (Loliolid) is a β-carotene metabolite. Loliolide reduces caspase 3, 8, 9 expression, enhances PI3K, AKT, SIRT1, inhibits ROS, apoptosis, and blocks NF-κB p65 nuclear translocation. Loliolide protects mitochondria, reduces oxidative stress, and increases cell viability in neuroblastoma cells. Loliolide can be used for the research of UV-induced skin damage and Parkinsons disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Loliolid; Digiprolactone. CAS No. 5989-2-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-118020A. | |
| LOM612 | LOM612 is a potent FOXO relocator, with an EC50 value of 1.5 μM in U2fox RELOC cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2173232-79-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101035. | |
| Lomeguatrib | Lomeguatrib is a O6-methylguanine-DNA methyltransferase (MGMT) inhibitor, with IC50s of 9 nM in cell-free assay and ~6?nM in MCF-7 cells. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PaTrin-2. CAS No. 192441-08-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13668. | |
| Lomerizine dihydrochloride | Lomerizine dihydrochloride is an antagonist of L- and T-type voltagegated calcium channels. Uses: Scientific research. Category: Signaling pathways. Alternative Names: KB-2796. CAS No. 101477-54-7. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 50 mg; 100 mg. Product ID: HY-B0768A. | |
| Lometrexol | Lometrexol (DDATHF), an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol has anticancer activity. Lometrexol also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DDATHF. CAS No. 106400-81-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14521. | |
| Lometrexol disodium | Lometrexol (DDATHF) disodium, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol disodium can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol disodium has anticancer activity. Lometrexol disodium also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DDATHF disodium. CAS No. 120408-07-3. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg. Product ID: HY-14521A. | |
| Lomitapide | Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AEGR-733; BMS-201038. CAS No. 182431-12-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-14667. | |
| Lomitapide mesylate | Lomitapide (AEGR-733; BMS-201038) mesylate is an orally active microsomal triglyceride transfer protein (MTP) inhibitor and a selective mTORC1 inhibitor with lipid-lowering activity and BBB permeability. Lomitapide mesylate significantly reduces plasma LDL levels by blocking the assembly and secretion of very-low-density lipoprotein (VLDL). Lomitapide mesylate inhibits mTORC1 in an ATP-dependent manner, thereby inducing AMPK-independent autophagic cell death and suppressing cancer cell growth and apoptosis. Lomitapide mesylate also enhances tumor infiltration of CD8+ T cells. In addition, Lomitapide mesylate inhibits HDAC, improves endothelial function, effectively alleviates vascular inflammation and oxidative stress, and exerts neuroprotective effects in a cerebral ischemia/reperfusion injury model. Lomitapide mesylate can be used in research on related diseases such as colorectal cancer, breast cancer, melanoma, ischemic stroke, and familial hypercholesterolemia[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AEGR-733 mesylate; BMS-201038 mesylate. CAS No. 202914-84-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14668. | |
| Lomustine | Lomustine (CCNU; NSC 79037) is a DNA alkylating agent, with antitumor activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CCNU; NSC 79037. CAS No. 13010-47-4. Pack Sizes: 10 mM * 1 mL in DMSO; 200 mg; 500 mg. Product ID: HY-13669. | |
| Lonafarnib | Lonafarnib (Sch66336) is a potent and orally active, and CNS-penetrant farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC50 values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Sch66336. CAS No. 193275-84-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15136. | |
| Loncastuximab | Loncastuximab (RB4v1.2) is an anti-CD19 monoclonal antibody. Loncastuximab has antitumor activity and can be used in the research of Non-Hodgkin Lymphoma (NHL) and Diffuse Large B-cell Lymphoma (DLBCL). Loncastuximab is capable of synthesizing the ADC molecule Loncastuximab tesirine (HY-P99349)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RB4v1.2. CAS No. 1875032-68-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99711. | |
| Loncastuximab tesirine | Loncastuximab tesirine is a human cluster of differentiation 19 (CD19)-directed antibody-drug conjugate (ADC). The antibody portion is Loncastuximab (HY-P99711), and the drug-linker conjugate for ADC is Tesirine (HY-128952). Once bound to CD19 on the cell membrane, loncastuximab tesirine is rapidly internalised and triggers cell death. Loncastuximab tesirin induces cell apoptosis, it can be used for the research of diffuse large B-cell lymphoma[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Loncastuximab tesirine-lpyl; ADCT-402. CAS No. 1879918-31-6. Pack Sizes: 100 μg; 200 μg; 500 μg; 1 mg. Product ID: HY-P99349. | |
| Londamocitinib | Londamocitinib (AZD4604) is a potent and selective JAK1 inhibitor with IC50 at 0.54 nM. Londamocitinib has anti-inflammatory activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD4604; JAK1-IN-7. CAS No. 2241039-81-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126294. | |
| (+)-Longifolene | (+)-Longifolene is a sesquiterpenoid and a metabolite in rabbits. (+)-Longifolen is converted to primary, secondary or tertiary alcohols in rabbits, among which the primary alcohol is predominant[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 475-20-7. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-N6662. | |
| Lonidamine | Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AF-1890; Diclondazolic Acid; DICA. CAS No. 50264-69-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0486. | |
| Lonigutamab | Lonigutamab (hz208F2-4) is a humanized anti-IGF-1R monoclonal antibody, serveing as a targeting vector for antibody-drug conjugates (ADCs). Lonigutamab causes G2-M phase cell cycle arrest and increases apoptosis in IGF-1R-overexpressing tumor cells. Lonigutamab demonstrates potent antitumor efficacy in IGF-1R-overexpressing xenograft models. Lonigutamab can be used for the study of Solid tumors with overexpression of IGF-1R and thyroid eye diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: hz208F2-4. CAS No. 2362015-67-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99712. | |
| LONP1-IN-2 | LONP1-IN-2 (Compound 9e) is a potent and selective LONP1 inhibitor with an IC50 value of 0.093 μM. LONP1-IN-2 can be used in research of cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2729981-17-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-153034. | |
| Loperamide | Loperamide (ADL 2-1294) is selective and orally active μ opioid receptor agonist with Ki valuess of 3, 48 and 1156 nM against μ, δ and κ opioid receptor, respectively. Loperamide produces antinociception and antihyperalgesia. Loperamide exhibits peripheral selectivity, enhancing fluid, electrolyte, and glucose absorption, reversing PGE2 (HY-101952)- and Cholera toxin (HY-P1446)-induced intestinal secretion, and reducing intestinal motility. Loperamide can be used for the researches of inflammatory pain and protracted diarrhoea[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ADL 2-1294. CAS No. 53179-11-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156131. | |
| Loperamide hydrochloride | Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist[1][2][3]. Loperamide hydrochloride is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. Loperamide hydrochloride has anti-diarrheal effect[4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R-18553 hydrochloride. CAS No. 34552-83-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B0418A. | |
| Loperamide hydrochloride (Standard) | Loperamide (hydrochloride) (Standard) is the analytical standard of Loperamide (hydrochloride). This product is intended for research and analytical applications. Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist[1][2][3]. Loperamide hydrochloride is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. Loperamide hydrochloride has anti-diarrheal effect[4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R-18553 hydrochloride (Standard). CAS No. 34552-83-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0418AR. | |
| Lopinavir | Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity[1][2]. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABT-378. CAS No. 192725-17-0. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg. Product ID: HY-14588. | |
| Loracarbef hydrate | Loracarbef hydrate, a cephalosporin antibiotic, is an orally active second-generation synthetic beta-lactam antibiotic of the carbacephem class[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 121961-22-6. Pack Sizes: 1 mg. Product ID: HY-B1682A. | |
| Loratadine | Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Loratidine; SCH 29851. CAS No. 79794-75-5. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg. Product ID: HY-17043. | |
| Loratadine (Standard) | Loratadine (Standard) is the analytical standard of Loratadine. This product is intended for research and analytical applications. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Loratidine (Standard); SCH 29851 (Standard). CAS No. 79794-75-5. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17043R. | |
| Lorigerlimab | Lorigerlimab (MGD019) is a bispecific IgG4 dual-affinity re-targeting antibody (DART). Lorigerlimab can block PD-1 and CTLA-4, and improves T-cell responses. Lorigerlimab can be used for research of metastatic castration-resistant prostate cancer (mCRPC)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MGD019. CAS No. 2416595-46-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99714. | |
| Lorlatinib | Lorlatinib (PF-06463922) is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor with anticancer activity. Lorlatinib has Kis of <0.025 nM, <0.07 nM, and 0.7 nM for ROS1, wild type ALK, and ALKL1196M, respectively. Lorlatinib targets to EML4-ALK, and inhibits ALK phosphorylation with IC50s of 15-43 nM (ALKL1196), 14-80 nM (ALKG1269A), 38-50 nM (ALK1151Tins), 77-113 nM (ALKG1202R), respectively[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-06463922. CAS No. 1454846-35-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12215. | |
| Lorlatinib (Standard) | Lorlatinib (Standard) is the analytical standard of Lorlatinib. This product is intended for research and analytical applications. Lorlatinib (PF-06463922) is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor with anticancer activity. Lorlatinib has Kis of <0.025 nM, <0.07 nM, and 0.7 nM for ROS1, wild type ALK, and ALKL1196M, respectively. Lorlatinib targets to EML4-ALK, and inhibits ALK phosphorylation with IC50s of 15-43 nM (ALKL1196), 14-80 nM (ALKG1269A), 38-50 nM (ALK1151Tins), 77-113 nM (ALKG1202R), respectively[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-06463922 (Standard). CAS No. 1454846-35-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12215R. | |
| L-Ornithine | L-Ornithine ((S)-2,5-Diaminopentanoic acid) is a non-proteinogenic amino acid, is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine shows nephroprotective[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (S)-2,5-Diaminopentanoic acid. CAS No. 70-26-8. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg. Product ID: HY-B1352. | |
| L-Ornithine-1,2,3,4,5-13C5 hydrochloride | L-Ornithine-1,2,3,4,5-13C5 (hydrochloride) is the 13C-labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen. Uses: Scientific research. Category: Signaling pathways. CAS No. 943962-21-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W017018S2. | |
| L-Ornithine-15N2 hydrochloride | L-Ornithine-15N2 (hydrochloride) is the 15N-labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen. Uses: Scientific research. Category: Signaling pathways. CAS No. 360565-59-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-W017018S5. | |
| L-Ornithine 2-oxoglutarate | L-Ornithine 2-oxoglutarate (Ornithine alpha-ketoglutarate) is a nutritional compound that is a salt of amino acids with antioxidant and anti-inflammatory effects. L-Ornithine 2-oxoglutarate stimulates the production of insulin and growth hormone, and promotes intracellular amino acid transport and protein synthesis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ornithine α-ketoglutarate; OKG. CAS No. 5191-97-9. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-131514. | |
| L-Ornithine-d6 hydrochloride | L-Ornithine-d6 (hydrochloride) is the deuterium labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen. Uses: Scientific research. Category: Signaling pathways. CAS No. 347841-40-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-W017018S. | |
| L-Ornithine-d7 hydrochloride | L-Ornithine-d7 (hydrochloride) is the deuterium labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen. Uses: Scientific research. Category: Signaling pathways. CAS No. 2483831-57-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W017018S4. | |
| L-Ornithine hydrochloride | L-Ornithine hydrochloride is a non-proteinogenic amino acid, is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine hydrochloride shows nephroprotective[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3184-13-2. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-W017018. | |
| Loroglossin | Loroglossin (compound 5) is a succinate derivative. Loroglossin can isolated from dried rhizomes of Gymnadenia conopsea[1]. Uses: Scientific research. Category: Natural products. CAS No. 58139-22-3. Pack Sizes: 1 mg. Product ID: HY-125100. | |
| Lorundrostat | Lorundrostat (MT-4129) is an orally active aldosterone synthase inhibitor. Lorundrostat can be used in studies of high blood pressure[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MT-4129. CAS No. 1820940-17-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-147277. | |
| Lorvotuzumab | Lorvotuzumab (Anti-NCAM1/CD56 Reference Antibody (lorvotuzumab)) is a humanized monoclonal antibody that binds CD56 (NCAM1). Lorvotuzumab can be used to synthesize an ADC compound, Lorvotuzumab mertansine[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Anti-NCAM1/ CD56 Reference Antibody (lorvotuzumab). CAS No. 339306-30-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99372. | |
| Losartan | Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DuP-753. CAS No. 114798-26-4. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-17512. | |
| Losartan Carboxylic Acid | Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: E-3174; EXP-3174. CAS No. 124750-92-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12765. | |
| Losartan-d4 | Losartan-d4 is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DuP-753 d4. CAS No. 1030937-27-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-17512S. | |
| Losartan potassium | Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC50 of 20 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DuP-753 potassium. CAS No. 124750-99-8. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-17512A. | |
| Losmapimod | Losmapimod (GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor with pKis of 8.1 and 7.6 for p38α and p38β, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSK-AHAB; GW856553X; SB856553. CAS No. 585543-15-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10402. | |
| Lotaustralin | Lotaustralin is a cyanogenic glucoside isolated from Manihot esculenta [1]. Uses: Scientific research. Category: Natural products. CAS No. 1973415-50-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N5079. | |
| Loteprednol Etabonate | Loteprednol etabonate (LE) is an orally active "soft" steroid belonging to a unique class of glucocorticoids. Loteprednol etabonate (LE) exhibits anti-inflammatory activity and has been used in optometry and ophthalmology[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 82034-46-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17358. | |
| Lotiglipron | Lotiglipron (PF-07081532) is an orally active GLP-1R agonist. Lotiglipron reduces glucose and body weight, and can be used for research of Type 2 diabetes mellitus (T2DM)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-07081532. CAS No. 2401892-75-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153865. | |
| Lotilaner | Lotilaner is a parasiticide, acts as a potent non-competitive antagonist of insects GABACl receptors, with an IC50 of 23.84 nM for Drosophila melanogaster GABA receptor. No effect on a dog GABAA receptor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1369852-71-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116564. | |
| Lotusine | Lotusine is an orally active signaling pathway modulator and enzyme inhibitor, with an IC50 of 30.60 μg/mL against α-amylase and an IC50 of 36.15 μg/mL against α-glucosidase. Lotusine inhibits the EGFR-Akt-ERK signaling pathway by reducing the levels of phosphorylated EGFR, Akt and ERK. Lotusine induces apoptosis, triggers G0/G1 cell cycle arrest and inhibits cancer cell proliferation. Lotusine reduces lipid peroxidation and increases the activities of SOD, CAT and GPx. Lotusine is applicable to researches related to non-small cell lung cancer, type 2 diabetes and autism spectrum disorder[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6871-67-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N4309. | |
| Lovastatin | Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Mevinolin. CAS No. 75330-75-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-N0504. | |
| Lovastatin hydroxy acid sodium | Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Mevinolinic acid sodium. CAS No. 75225-50-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-123672. | |
| Lovastatin (Standard) | Lovastatin (Standard) is the analytical standard of Lovastatin. This product is intended for research and analytical applications. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Mevinolin (Standard). CAS No. 75330-75-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0504R. | |
| Loxapine succinate | Loxapine succinate is an orally active dopamine inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent. Loxapine can also suppresses bacterial efflux pump activity and inhibit intracellular multiple-antibiotic-resistant Salmonella enterica serovar Typhimurium in macrophages[1][4][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 27833-64-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-17390A. | |
| LP01 | LP01 (Example 13) is a cationic lipid used in the delivery of biologically active agents to cells and tissues[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1799316-64-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-46760. | |
| LP17 | LP17 (LQVTDSGLYRCVIYHPP) is a BBB-penetrable triggering receptor expressed on myeloid cells (TREM-1) inhibitory peptide. LP17 substantially alleviates ischemia-induced infarction and neuronal injury. LP17 can get access into brain and block TREM-1[1]. Uses: Scientific research. Category: Peptides. Alternative Names: LQVTDSGLYRCVIYHPP. CAS No. 887255-16-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3400. | |
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