MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| LY-411575 | LY-411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), and also inhibits Notch S3 cleavage with an IC50 of 0.39 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 209984-57-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-50752. |  |
| LY450108 | LY450108 is a potent AMPA receptor potentiator. LY450108 has the potential for depression and Parkinson's disease research[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 376594-67-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10935. | |
| LY83583 | LY83583 is inhibitor of soluble guanylate cyclase (sGC) with the ability to target the cGMP signaling pathway. LY83583 inhibits the kinase activity-related proliferation of tumor cells by inducing the Cdk inhibitor p21. LY83583 can be used for the study of cancers (colorectal cancer, breast cancer and melanoma) and cardiovascular disease[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 91300-60-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W013386. | |
| Ly93 | Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC50 of 91 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1883528-69-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114307. | |
| Lyciumin A | Lyciumin A, a cyclic octapeptide, exhibits inhibitory activity on proteases, renin and angiotensin-converting enzyme. Lyciumin A can be used for the research of hypertension[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 125708-06-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N9528. | |
| Lyciumin B | Lyciumin B is a cyclic peptide isolated from Lysium chinense[1]. Uses: Scientific research. Category: Natural products. CAS No. 125756-66-3. Pack Sizes: 1 mg. Product ID: HY-N9526. | |
| Lycopene | Lycopene is naturally occurring carotenoids found in tomato, tomato products, and in other red fruits and vegetables; exhibits antioxidant effects. Uses: Scientific research. Category: Signaling pathways. CAS No. 502-65-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0287. | |
| Lycorine | Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a Kd value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription[2]. Lycorine is also a melanoma vasculogenic inhibitor[3]. Lycorine can be used for the study of prostate cancer and metabolic diseases[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 476-28-8. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-N0288. | |
| Lycorine hydrochloride | Lycorine hydrochloride is the main active ingredient of the herbal medicine derived from Lycoris radiata (LHer.) Herb. and is also a melanoma vasculogenic inhibitor and has anti-tumor activity[1]. Lycorine hydrochloride effectively inhibits mitotic proliferation of Hey1B cells (IC50 of 1.2 μM)[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2188-68-3. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-N0289. | |
| LYG-409 | LYG-409 is an orally active degrader of GSPT1. LYG-409 shows excellent anti-acute myeloid leukemia and prostate cancer in vivo with TGI of 94.34% and 104.49%, respectively. LYG-409 inhibits KG-1 cells mediated by the degradation of GSPT1 with an IC50 of 9.50 nM, with a DC50 of 7.87 nM in vitro[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3053857-55-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-170952. | |
| Lymecycline | Lymecycline is a tetracycline derivative, with broad-spectrum antibacterial activity and also has anti-inflammatory property. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Mucomycin. CAS No. 992-21-2. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg. Product ID: HY-106339. | |
| LYN-1604 | LYN-1604 is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2088939-99-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101923. | |
| Lyn-IN-1 | Lyn-IN-1 (Bafetinib analog) is a Lyn kinase inhibitor for the study of thrombocytopenia[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Bafetinib analog. CAS No. 887650-05-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12039. | |
| Lyn peptide inhibitor | Lyn peptide inhibitor (YGYRLRRKWEEKIPNP-NH2) is a potent, cell-permeable Lyn kinase inhibitor that inhibits Lyn-coupled signaling pathways associated with the IL-5 receptor while preserving the integrity of other signals. Lyn peptide inhibitor blocks the activation of Lyn and inhibits the binding of Lyn tyrosine kinase to the βc subunit of the IL-3/GM-CSF/IL-5 receptor. Lyn peptide inhibitor can be used in the research of eosinophilic diseases such as asthma and allergy[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 222018-18-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P1111. | |
| LyP-1 | LyP-1 is a cyclic 9-amino-acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 454487-07-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2526. | |
| LYP-IN-1 | LYP-IN-1 is a potent, selective and specific LYP inhibitor with a Ki and an IC50 of 110 nM and 0.259 μM, respectively. LYP-IN-1 also has selectivity for a large panel of PTPs, such as SHP1 (IC50=5 μM) and SHP2 (IC50=2.5 μM). LYP-IN-1 exhibits highly efficacious cellular activity in T- and mast cells. LYP-IN-1 can be used for the study of autoimmune disorders[1]. LYP-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1404436-51-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108944. | |
| LYP-IN-3 | LYP-IN-3 is a selective, orally active and reversible lymphoid-tyrosine phosphatase (LYP) inhibitor (IC50 = 2.55 μM, Ki = 0.93 μM). D34 exhibits high selectivity of PTP1B, PTPN12, PTPN5 and SSH2. LYP-IN-3 regulates the T-cell receptor (TCR) signaling by specifically inhibiting LYP. LYP-IN-3 does not significantly inhibit MC38 cell viability; its anti-tumor effect stems from immune regulation. LYP-IN-3 can significantly upregulate PD-L1 or PD-1 expression in different immune cells. LYP-IN-3 facilitates T-cell infiltration and enhances T-cell functions. LYP-IN-3 synergizes with PD-L1 blockade can significantly improve colorectal tumor regression. LYP-IN-3 can be used for the study of colorectal cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3052262-64-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-155847. | |
| Lys05 | Lys05 (Lys01 trihydrochloride) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Lys01 trihydrochloride. CAS No. 1391426-24-6. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12855A. | |
| Lysipressin | Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs. Lysipressin activates Oxytocin receptors and adenylate-cyclase. Lysipressin adjusts blood pressure and heart rate. Lysipressin shows antinociceptive activity[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Lysine vasopressin; [Lys8]-Vasopressin. CAS No. 50-57-7. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P0004. | |
| Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 | Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 is a cleavable antibody agent conjugate linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1224601-12-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-131157. | |
| Lyso-PAF C-16 | Lyso-PAF C-16 is a precursor and metabolite of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (PAF C-16). Lyso-PAF C-16 is a substrate for either PAF C-16 formation by the remodeling pathway or selective acylation with arachidonic acid by a CoA-independent transacylase[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 52691-62-0. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg. Product ID: HY-141570. | |
| Lyso-PAF C-18 | Lyso-PAF C-18 is an intermediate for the synthesis of C18-PAF (HY-130345). It has an easily substituted "Lyso-PAF" structure and is easy to purify and has high yield. C18-PAF is a ligand for platelet-activating factor and PAF G protein-coupled receptor (PAFR) and has renovasodilator properties and antihypertensive lipid properties[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 74430-89-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-141581. | |
| LysoPC(20:4) | LysoPC 20:4 (20:4) (1-Arachidonoyl-sn-glycero-3-phosphocholine) is a serum metabolite. LysoPC 20:4 (20:4) decreases in tumor-bearing mice, but the reduction is not significant. LysoPC (20:4) can be used in cancer and obesity-related research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1-Arachidonoyl-sn-glycero-3-phosphocholine. CAS No. 60701-99-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-177475. | |
| LysoPE(18:2/0:0) | LysoPE (18:2/0:0) is a lysophosphatidylethanolamine implicated in phospholipid metabolism. LysoPE (18:2/0:0) shows significantly altered serum levels in mice exposed to a combination of DEHP (HY-B1945) and Aroclor 1254, which is associated with disturbed phospholipid metabolism. LysoPE (18:2/0:0) can be used for the research of endocrine-disrupting compound-induced metabolic disorders and lipid metabolism disturbance. LysoPE (18:2/0:0) is identified as a potential biomarker for the combined toxicity of DEHP and Aroclor 1254[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 85046-18-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-154918. | |
| Lysophosphatidylcholine 18:2 | Lysophosphatidylcholine 18:2 (1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC), a lysophospholipid, is a potential biomarker identified from insulin resistance (IR) polycystic ovary syndrome (PCOS). Low plasma Lysophosphatidylcholine 18:2 also has been shown to predict impaired glucose tolerance, insulin resistance, type 2 diabetes, coronary artery disease, and memory impairment[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC; LPC(18:2/0:0); LysoPC(18:2). CAS No. 22252-07-9. Pack Sizes: 10 mM * 1 mL in Ethanol; 1 mg; 5 mg; 10 mg. Product ID: HY-N9410. | |
| Lysophosphatidylcholines | Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of IL-1β and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9008-30-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139414. | |
| Lysophosphatidylethanolamines, egg | Lysophosphatidylethanolamine (LPE) is a naturally-occurring lysophospholipid that can be generated via deacylation of phosphatidylethanolamine by phospholipase A2 (PLA2). It increases the phosphorylation of ERK1/2 in PC12 cells, an effect that can be blocked by the MEK inhibitors U-0126 (HY-12031A) and PD 98059 (HY-12028) and the EGFR inhibitor AG-1478 (HY-13524).1 LPE also increases neurite outgrowth and expression of neurofilament M in PC12 cells. LPE inhibits the activity of phospholipase D (PLD) partially purified from cabbage.3 This product contains lysophosphatidylethanolamine molecular species with variable fatty acyl chain lengths at the sn-1 position and a hydroxy group at the sn-2 position. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Lyso-PE (egg); LPE (egg); L-α-lysophosphatidylethanolamine. CAS No. 97281-40-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-156041. | |
| Lysostaphin | Lysostaphin is an antistaphylococcal agent. Lysostaphin has activities of three enzymes namely, glycylglycine endopeptidase, endo-β-N-acetyl glucosamidase and N-acteyl muramyl-L-alanine amidase[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9011-93-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2329. | |
| LysoTracker Blue DND-22 | LysoTracker blue DND-22 is a blue fluorescent dye (Ex/Em: 373/422 nm). LysoTracker blue DND-22 stains acidic regions in living cells. LysoTracker blue DND-22 is used in the researches of neurodegenerative diseases and leukemia[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 215247-93-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D1775. | |
| LysoTracker Red | LysoTracker Red is a Red fluorescently labeled lysosomal probe with a maximum excitation/emission wavelength of 577/590 nm. The structure is composed of a fluorescein group and linked weak bases, which can freely cross the cell membrane and gather on spherical organelles. It is suitable for observing the internal biosynthesis and related pathogenesis of lysosomes[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LysoTracker Red DND-99. CAS No. 231946-72-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-D1300. | |
| LysoTracker Red (solution) | LysoTracker Red (solution) is a Red fluorescently labeled lysosomal probe with a maximum excitation/emission wavelength of 577/590 nm. The structure is composed of a fluorescein group and linked weak bases, which can freely cross the cell membrane and gather on spherical organelles. It is suitable for observing the internal biosynthesis and related pathogenesis of lysosomes[1].Solvent and concentration: DMSO: 1 mM. Uses: Scientific research. Category: Signaling pathways. CAS No. 231946-72-8. Pack Sizes: 50 μL; 100 μL. Product ID: HY-DY1040. | |
| LysoTracker Yellow HCK 123 | LysoTracker Yellow HCK 123 is a potent yellow membrane-permeable fluorescent probe. LysoTracker Yellow HCK 123 is a weakly basic amine that selectively accumulates in cellular compartments with low luminal pH[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1064123-31-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-D1694. | |
| Lysozyme from chicken egg white | Lysozyme from chicken egg white is a bactericidal enzyme, and it lyses gram-positive bacteria. Lysozyme from chicken egg white can also be used for the research of HIV infection and pulmonary emphysema[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 12650-88-3. Pack Sizes: 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B2237. | |
| LysRs-IN-2 | LysRs-IN-2 is a lysyl-tRNA synthetase (KRS) inhibitor with IC50s of 0.015 μM and 0.13 μM for Plasmodium falciparum lysyl-tRNA synthetase (PfKRS) and Cryptosporidium parvum lysyl-tRNA synthetase (CpKRS), respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2170696-76-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-126130. | |
| Lys-SMCC-DM1 | Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is a agent-linker conjugates for ADC that can inhibit tubulin polymerization. Lys-SMCC-DM1 is the active metabolite of T-DM1. T-DM1 is a HER2-targeting ADC with a tubulin polymerization inhibitor DM1. Lys-SMCC-DM1 can be used in the research of breast cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Lys-Nε-MCC-DM1. CAS No. 1281816-04-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-101982. | |
| Lysyl endopeptidase, Achromobacter sp | Lysyl endopeptidase, Achromobacter sp (Lys-C) catalyzes carboxyl oxygen exchange reaction. Lysyl endopeptidase has higher substrate binding affinities and higher catalytic rates at the acidic pHs than at the alkaline pHs[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Lys-C. CAS No. 123175-82-6. Pack Sizes: 20 μg. Product ID: HY-P3205. | |
| Lysylglutamic acid | Lysylglutamic acid is a dipeptide formed by combining two amino acids, Lysine (Lys) and Glutamic acid (Glu). The Ki value of the membrane transporter PEPT1 was 1.3 mM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 45234-02-4. Pack Sizes: 10 mM * 1 mL in Water; 25 mg; 50 mg; 100 mg. Product ID: HY-W327145. | |
| Lysyl hydroxylase 2-IN-1 | Lysyl hydroxylase 2-IN-1 (compound 12) is a selective lysyl hydroxylase 2 (LH2) Inhibitor with an IC50 of ~300 nM. Lysyl hydroxylase 2-IN-1 demonstrates selectivity for LH2 over LH1 and LH3[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3053862-11-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149597. | |
| M-110 | M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for PIM-3 (IC50=47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC50s of 2.5 μM. M-110 inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1395048-49-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12830. | |
| M1145 | M1145, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher affinity over GalR3 (Ki=497 nM). M1145 has an additive effect on the signal transduction of galanin[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1172089-00-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1135. | |
| M190S | M109S is a novel small molecule protecting cells from mitochondria-dependent apoptosis both in vitro and in vivo. M109S has the potential to become a research tool for studying cell death mechanisms and to develop therapeutics targeting mitochondria-dependent cell death pathway. M109S has orally bioactivity with excellent brain permeability[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2578300-07-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156168. | |
| M2698 | M2698 (MSC2363318A) is an orally active, ATP competitive, selective p70S6K and Akt dual-inhibitor with IC50s of 1 nM for p70S6K, Akt1 and Akt3. M2698 can cross the blood-brain barrier and has anti-cancer activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MSC2363318A. CAS No. 1379545-95-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100501. | |
| M-31850 | M-31850 is a potent, selective and competitive β-hexosaminidase (Hex) inhibitor with IC50s of 6.0 μM and 3.1 μM for human HexA and human HexB, respectively. M-31850 also competitively inhibits β-N-acetyl-D-hexosaminidase OfHex2 with a Ki of 2.5 μM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 281224-40-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104050. | |
| M3258 | M3258 is an orally bioavailable, potent, reversible and highly selective immunoproteasome subunit LMP7 (β5i) inhibitor. M3258 exerts high biochemical (IC50=3.6 nM) and cellular (IC50=3.4 nM) potency against the LMP7 subunit. M3258 shows strong antitumor efficacy in multiple myeloma xenograft models. M3258 leads to a significant and prolonged suppression of tumor LMP7 activity and ubiquitinated protein turnover and the induction of apoptosis in multiple myeloma cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2285330-15-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-111790. | |
| M344 | M344 (D 237) is an inhibitor of histone deacetylase (IC50=100 nM) and an inducer of terminal cell fifferentiation. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D 237; MS 344. CAS No. 251456-60-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13506. | |
| M351-0056 | M351-0056 is the agonist for the immune checkpoint protein VISTA, that reduces the secretion of VISTA-induced cytokines, promotes the T-cell proliferation induced by VISTA, and exhibits immunomodulatory activity. M351-0056 ameliorates Imiquimod (HY-B0180)-induced psoriatic dermatitis in mouse models[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1189495-81-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-169853. | |
| M3541 | M3541 is a potent, ATP-competitive and selective ATM inhibitor with an IC50 of 0.25 nM. M3541 shows remarkable selectivity against other protein kinases. M3541 suppresses double-strand breaks (DSB) repair and has antitumor activities[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1360628-91-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-160096. | |
| m-3M3FBS | m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 200933-14-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19619. | |
| M435-1279 | M435-1279 is a UBE2T inhibitor. M435-1279 inhibits the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1359431-16-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141891. | |
| M443 | M443 is an irreversible and specific inhibitor of MRK, with an IC50<125 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1820684-31-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112274. | |
| M47 | M47 is a molecular glue that selectively destabilizes Cryptochrome 1 (CRY1) and increases degradation of the CRY1 in the nucleus. M47 enhances apoptosis in Ras-transformed P53-deficient mouse skin fibroblast lines and enhances life span in p53 knockout mice. M47 can be used in research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 890808-56-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148764. | |
| M4K-2009 | M4K-2009 is an orally bioactive ALK2 inhibitor with an IC50 of 13 nM. M4K-2009 exerts comparable inhibitory potency against wild-type and mutant ALK2G328V, ALK2R206H, and ALK2R258G. M4K-2009 exhibits moderate off-target inhibitory activity against hERG potassium channels. M4K-2009 can be used in studies related to diffuse intrinsic pontine glioma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2600795-07-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149591. | |
| M4K2163 dihydrochloride | M4K2163 dihydrochloride is a potent, selective, blood-brain barrier (BBB) permeable activin receptor-like kinase-2 (ALK2) inhibitor, with an IC50 of 19 nM. M4K2163 dihydrochloride can be used in the research of diffuse intrinsic pontine glioma (DIPG)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2863635-04-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-155939. | |
| M4K2234 | M4K2234, a chemical probe, is an orally active, highly selective inhibitor of ALK1 and ALK2 with IC50 values of 7 nM and 14 nM, respectively. M4K2234 specifically blocks BMP signaling by inhibiting the phosphorylation of SMAD1/5/8. M4K2234 inhibits BMP7-stimulated reporter gene activity (IC50 = 16 nM). M4K2234 can be used for the investigation of ALK1/2-mediated biological processes and related diseases such as diffuse midline glioma (DMG) and fibrodysplasia ossificans progressiva (FOP)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2421141-51-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148234. | |
| M5N36 | M5N36 is a potent and selective Cdc25C inhibitor with IC50 values of 0.15, 0.19, 0.06 μM for Cdc25A, Cdc25B, Cdc25C, respectively. M5N36 shows anti-proliferative activity and increases the expression of p-CDK1 and p-CDK2[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2832887-40-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132578. | |
| M617 | M617 is a selective galanin receptor 1 (GAL1) agonist, with Kis of 0.23 and 5.71 nM for GAL1 and GAL2, respectively. M617, acting through its central GAL1, can promote GLUT4 expression and enhance GLUT4 content in the cardiac muscle of type 2 diabetic rats[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 860790-38-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1131. | |
| M6766 | M6766 is a selective endoplasmic reticulum oxidoreductase 1α (ERO1α) inhibitor with an IC50 of 1.4 μM and a KD of 1.1 μM. M6766 also inhibits ERO1β with an IC50 of 7.2 μM. M6766 binds to the flavin adenine dinucleotide-binding pocket in ERO1α. M6766 inhibits granule secretion, αIIbβ3 integrin activation, Ca2+ mobilization, and platelet aggregation. M6766 can be used for the research of neurological disease, such as ischemic stroke[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 696628-90-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-175593. | |
| M700F048 | M700F048 is a major plant metabolite of fungicide Fluxapyroxad[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2056235-51-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-111741. | |
| M701 | M701 is a T-cell engager bispecific humanized antibody targeting epithelial cell adhesion molecule (EpCAM) and cluster of differentiation 3 (CD3). M701 binds to EpCAM on tumor cells and CD3 on T cells, thereby linking the two cell populations to achieve targeted cytotoxicity and T cell-mediated cytotoxicity. M701 is applicable to research related to advanced epithelial solid tumors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2933295-42-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P991526. | |
| m7(3'OMeG)(5')pp-1-imidazol | m7(3'OMeG)(5')pp-1-imidazol is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Category: Signaling pathways. CAS No. 2089461-53-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-172307. | |
| M7594_0037 | M7594_0037 is a potent inhibitor of human peptide deformylase (HsPDF) that has anti-tumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 774551-07-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-122097. | |
| m7GpppAmpG ammonium solution (100 mM) | m7GpppAmpG ammonium (m7G(5')ppp(5')(2'OMeA)pG ammonium) is a trinucleotide 5 end cap analog. m7GpppAmpG ammonium binds to eIF4E with a KD value of 45.6 nM. m7GpppAmpG ammonium caps RNA with a capping efficiency of 90%. m7GpppAmpG ammonium enhances mRNA stability and translation efficiency. m7GpppAmpG ammonium is used in mRNA therapeutic research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: m7G(5')ppp(5')(2'OMeA)pG ammonium. CAS No. 3080642-79-8. Pack Sizes: 20 μL; 50 μL; 100 μL; 200 μL. Product ID: HY-145974A. | |
| M-808 | M-808 is a highly potent and efficacious covalent Menin-MLL interaction inhibitor, with a binding IC50 value of 2.6 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2377335-74-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-133738. | |
| M871 | M871 (Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide) is an orally active and selective galanin receptor type 2 (GalR2) antagonist. M871 exhibits Ki values of 13.1 nM, 420 nM and >10 μM for GalR2, GalR1 and GalR3 respectively. M871 relieves the mice allergic rhinitis by reducing IgE production, as well as the number of B cells in tissues. M871 can inhibit the nerve invasion of salivary adenoid cystic carcinoma (SACC) and alleviate myocardial ischemia-reperfusion injury. M871 can be used for research on GalR2-related diseases (such as epilepsy, pain)[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide. CAS No. 908844-75-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1130. | |
| M8891 | M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor with an IC50 of 54 nM and a Ki of 4.33 nM. M8891 does not inhibit MetAP-1 (IC50>10 μM)[1]. M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral activity[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1464842-09-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133016. | |
| MA-2029 | MA-2029 is a selective, orally active, and competitive motilin receptor antagonist (IC50=4.9 nM). MA-2029 is selective for the motilin receptor over various other receptors and ion channels. MA-2029 may be useful for gastrointestinal disorders associated with disturbed gastrointestinal motility[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 287206-61-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-107642. | |
| Maackiain | Maackiain (DL-Maackiain) is an orally active multi-target inhibitor with anti-tumor activity and neuroprotective effects. Maackiain activates the AMPK, NLRP3 and Nrf2/HO-1 pathways, and inhibits key targets such as NF-κB, mTOR, MAO-B, NFATc1 and PKCδ, thereby precisely regulating processes including apoptosis, autophagy and pyroptosis. Maackiain also effectively inhibits microglial activation, osteoclast formation, and proliferation and invasion of tumor cells, and protects dopaminergic neurons from damage. Maackiain is applicable to the research of various diseases such as Alzheimer's disease, osteoporosis, sepsis and dengue fever[1][2][3][4][5][6][7][8][9]?. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DL-Maackiain. CAS No. 19908-48-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N0381. | |
| Mab Aspartate Decarboxylase-IN-1 | Mab Aspartate Decarboxylase-IN-1 is a potent aspartate decarboxylase (PanD) inhibitor with an IC50 value of 56.3 μM. Mab Aspartate Decarboxylase-IN-1 shows antibacterial activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2755712-12-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150637. | |
| MAC13772 | MAC13772 is a BioA inhibitor with an IC50 of 0.28 μM against E. coli and an IC50 of 0.269 μM against A. baumannii. MAC13772 inhibits bacterial growth by targeting the biotin biosynthesis pathway. MAC13772 can be used in studies related to bacterial infections[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4871-40-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116872. | |
| MAC glucuronide linker-1 | MAC glucuronide linker-1 is a claevable ADC linker for antibody-agent-conjugations (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2222981-71-5. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-44221. | |
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