MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| MC-GGFG-AM-(10Me-11F-Camptothecin) intermediate-1 | MC-GGFG-AM-(10Me-11F-Camptothecin) intermediate-1 (compound 19-2) is an intermediate for the synthesis of MC-GGFG-AM-(10Me-11F-Camptothecin) (HY-153360). Modifying groups can be added group. MC-GGFG-AM-(10Me-11F-Camptothecin) is a drug-linker conjugate used in the synthesis of ADCs[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1-(2-Amino-4-fluoro-5-methylphenyl)-2-chloroethanone. CAS No. 1241391-14-9. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-400770. |  |
| MC-GGFG-Exatecan | MC-GGFG-Exatecan (MC-GGFG-DX8951) is a agent-linker conjugate for ADC. MC-GGFG-Exatecan is a DX8951 (a DNA topoisomerase I inhibitor) derivative with protease cleavable MC-GGFG linker. MC-GGFG-Exatecan shows antitumor activity and can be used to prepare DX8951 antibody conjugate (ADC)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MC-GGFG-DX8951. CAS No. 1600418-29-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114233. | |
| MC-GGFG-PAB-Exatecan | MC-GGFG-PAB-Exatecan (Compound 94) is a drug-linker conjugate for ADC, and can be used for synthesis of ADCs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2928560-25-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160967. | |
| MC-Gly-Gly-Phe | MC-Gly-Gly-Phe is a cleavable linker used for antibody-drug conjugates (ADC). Uses: Scientific research. Category: Signaling pathways. CAS No. 1599440-15-9. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-44235. | |
| MC-Gly-Gly-Phe-Gly | MC-Gly-Gly-Phe-Gly is a cleavable ADC linker used for antibody-drug conjugates (ADCs). Uses: Scientific research. Category: Signaling pathways. Alternative Names: Mc-GGFG-OH. CAS No. 2413428-36-9. Pack Sizes: 50 mg; 100 mg; 250 mg; 1 g; 5 g. Product ID: HY-44246. | |
| MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH | MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1599440-25-1. Pack Sizes: 50 mg; 100 mg; 250 mg; 1 g. Product ID: HY-131990. | |
| MC-Gly-Gly-Phe-Gly-PAB-MMAE | MC-Gly-Gly-Phe-Gly-PAB-MMAE (Compound SMP-81641) is a control targeted linker-agent conjugate. MC-Gly-Gly-Phe-Gly-PAB-MMAE can be used in tumor research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3055607-13-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-132134. | |
| MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan | MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan (SHR-A1811 Drug-linker) is a agent-linker conjugates for ADC, consisting Exatecan (HY-13631). Exatecan is a DNA Topoisomerase I inhibitor (IC50=2.2 μM)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SHR-A1811 Drug-linker. CAS No. 2414254-51-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-148668. | |
| MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan | MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan is a agent-linker conjugates for ADC, consisting Exatecan (HY-13631). Exatecan is a DNA Topoisomerase I inhibitor (IC50=2.2 μM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2414254-52-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-148668A. | |
| MCI-INI-3 | MCI-INI-3 is a selective competitive inhibitor of human ALDH1A3 (with a Ki value of 0.55 μM for ALDH1A3 and a Ki value of 78.2 μM for ALDH1A1). MCIINI-3 inhibits the biosynthesis of retinoic acid and reduces the viability of GSC-83 and GSC-326 glioblastoma cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1011366-31-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-169884. | |
| MCL-1/BCL-2-IN-1 | MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 4.45 and 3.18 μM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2493256-46-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129681. | |
| Mcl-1 inhibitor 6 | Mcl-1 inhibitor 6 is an orally active, selective myeloid cell leukemia 1 (Mcl-1) protein inhibitor with a Kd of 0.23 nM and a Ki of 0.02 μM. Mcl-1 inhibitor 6 possesses superior selectivity over other Bcl-2 family members (Bcl-2, Bcl2A1, Bcl-xL, and Bcl-w, Kd>10 μM). Mcl-1 inhibitor 6 is a potent antitumor agent[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2598978-56-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132307. | |
| Mc-MMAE | Mc-MMAE is a protective group (maleimidocaproyl)-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Mc-MMAE is a agent-linker conjugate for ADC. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Maleimidocaproyl-monomethylauristatin E. CAS No. 863971-24-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15741. | |
| McMMAF | McMMAF (Maleimidocaproyl monomethylauristatin F) is an active molecule linker for ADC, made by coupling the powerful microtubule inhibitor Monomethyl auristatin F (MMAF) (HY-15579) with the protecting group maleimidocaproyl. McMMAF can be conjugated with anti-BCMA antibodies to form J6M0-mcMMAF, promoting apoptosis and inhibiting tumor growth[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Maleimidocaproyl monomethylauristatin F. CAS No. 863971-19-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15578. | |
| McN3716 | McN3716 is a carnitine palmitoyltransferase I (CPT-1) inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Methyl palmoxirate; NSC359682. CAS No. 69207-52-9. Pack Sizes: 1 mg. Product ID: HY-U00159. | |
| MCOPPB trihydrochloride | MCOPPB trihydrochloride is a nociceptin receptor agonist with pKi of 10. Uses: Scientific research. Category: Signaling pathways. CAS No. 1108147-88-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13101. | |
| MCPA-d3 | MCPA-d3 is the deuterium labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 352431-14-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0859S1. | |
| m-CPBG hydrochloride | m-CPBG (1-(3-Chlorophenyl)biguanide) hydrochloride is a selective 5-HT3 agonist. m-CPBG hydrochloride can be used for the research of neurological disease[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1-(3-Chlorophenyl)biguanide hydrochloride. CAS No. 2113-5-5. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g. Product ID: HY-100938. | |
| Mc-Pro-PAB-MMAE | Mc-Pro-PAB-MMAE is a Drug-Linker Conjugate for ADC. Mc-Pro-PAB-MMAE consists of Monomethyl auristatin E (HY-15162) and a linker. Mc-Pro-PAB-MMAE can be used for synthesis of ADCs[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2766450-03-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-171060. | |
| MC-SN38 | MC-SN38 is a agent-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody agent conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1473403-87-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136170. | |
| MCT1-IN-2 | MCT1-IN-2 is a potent monocarboxylate transporter 1 (MCT1) inhibitor. MCT1-IN-2 has anti-cancer activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 227321-12-2. Pack Sizes: 5 mg. Product ID: HY-18974. | |
| MCT-IN-1 | MCT-IN-1 (Compound 2) is a potent MCT inhibitor, with IC50 values of 9 nM and 14 nM against MCT1 and MCT4, respectively. MCT-IN-1 can be used in research related to solid tumors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1685273-57-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-150314. | |
| MCU-i11 | MCU-i11 is a negative regulator of the mitochondrial calcium uniporter (MCU) complex. MCU-i11 can reduce mitochondrial Ca2+ uptake. MCU-i11 impairs muscle cell growth. MCU-i11 can be used to study breast cancer, cervical cancer and neurological diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 902903-59-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-W194810. | |
| MCU-i4 | MCU-i4 blocks the IP3-dependent mitochondrial Ca2+-uptake, maintaining the gatekeeping role of their target[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 371924-24-2. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138620. | |
| MC-Val-Ala-OH | MC-Val-Ala-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1342211-31-7. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-101153. | |
| Mc-?Val-?Ala-?PAB | Mc- Val- Ala- PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Uses: Scientific research. Category: Signaling pathways. CAS No. 1870916-87-2. Pack Sizes: 50 mg; 100 mg; 250 mg; 1 g; 5 g. Product ID: HY-126364. | |
| MC-Val-Ala-PAB-PNP | MC-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1639939-40-4. Pack Sizes: 50 mg; 100 mg; 250 mg; 1 g; 5 g. Product ID: HY-135975. | |
| MC-Val-Cit-PAB | MC-Val-Cit-PAB is a cleavable ADC Linker that forms part of VcMMAE (HY-15575). VcMMAE is Drug-Linker Conjugates for ADCs. The ADC Cytotoxin in VcMMAE is MMAE, a tubulin polymerization inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 159857-80-4. Pack Sizes: 5 mg; 10 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-78738. | |
| Mc-Val-Cit-PAB-Cl | Mc-Val-Cit-PAB-Cl is a cleavable ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay). Uses: Scientific research. Category: Signaling pathways. CAS No. 1639351-92-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112099. | |
| Mc-Val-Cit-PABC-PNP | Mc-Val-Cit-PABC-PNP is a cathepsin cleavable linker for antibody-drug conjugates (ADCs) which couples the antibody element to the effecting compound. Mc-Val-Cit-PABC-PNP can be used in the synthesis of ADCs[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate. CAS No. 159857-81-5. Pack Sizes: 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-20336. | |
| MC-Val-Cit-PAB-duocarmycin chloride | MC-Val-Cit-PAB-duocarmycin chloride is a agent-linker conjugate for ADC with potent antitumor activity by using Duocarmycin (a DNA minor groove binding alkylating agent), linked via the ADC linker MC-Val-Cit-PAB. Uses: Scientific research. Category: Signaling pathways. CAS No. 2055896-98-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-128904. | |
| MC-Val-Cit-PAB-Exatecan | MC-Val-Cit-PAB-Exatecan (MC-Val-Cit-PAB-DX8951) is a agent-linker conjugate for ADC. MC-Val-Cit-PAB-Exatecan is composed of a DNA topoisomerase I DX-8951 (HY-13631) and a cathepsin cleavable ADC linker. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MC-Val-Cit-PAB-DX8951. CAS No. 2504068-28-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145929. | |
| MC-Val-Cit-PAB-Indibulin | MC-Val-Cit-PAB-Indibulin is a agent-linker conjugate for ADC with potent antitumor activity by using Indibulin (an orally applicable inhibitor of tubulin assembly), linked via the ADC linker MC-Val-Cit-PAB. Uses: Scientific research. Category: Signaling pathways. CAS No. 2055896-95-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128908. | |
| MC-Val-Cit-PAB-Ispinesib | MC-Val-Cit-PAB-Ispinesib (Compound 509) is a drug-linker conjugate for ADC, consisting of a cleavable ADC linker and Eg5 inhibitor. MC-Val-Cit-PAB-Ispinesib can be used for the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1629737-40-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-160441. | |
| MC-Val-Cit-PAB-MMAF | MC-Val-Cit-PAB-MMAF (Vc-MMAF) is a drug-linker conjugate for ADC by using the tubulin inhibitor, MMAF (HY-15579), linked via cathepsin cleavable MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB-MMAF shows antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Vc-MMAF. CAS No. 863971-17-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112786. | |
| MC-Val-Cit-PAB-vinblastine | MC-Val-Cit-PAB-vinblastine is a agent-linker conjugate for ADC with potent antitumor activity by using vinblastine (an microtubule protein inhibitor), linked via the ADC linker MC-Val-Cit-PAB. Uses: Scientific research. Category: Signaling pathways. CAS No. 2055896-92-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-128902. | |
| MC-Val-D-Cit-PAB-PNP | MC-Val-D-Cit-PAB-PNP is a cleavable peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs). MC-Val-D-Cit-PAB-PNP contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-nitrophenol (PNP) group that allows the peptide to be linked to antitumor compounds. Uses: Scientific research. Category: Signaling pathways. CAS No. 1350456-66-4. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-147021. | |
| MC-VA-PABC-MMAE | MC-VA-PABC-MMAE is a agent-linker conjugate for ADC. MC-VA-PABC-MMAE contains the ADCs linker (peptide MC-VA-PABC) and a potent tubulin polymerization inhibitor MMAE (HY-15162)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1818864-51-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147239. | |
| MC-VA-PAB-Exatecan | MC-VA-PAB-Exatecan is a agent-linker conjugate for ADC. MC-VA-PAB-Exatecan contains the ADC linker (peptide MC-VA-PAB) and a DNA topoisomerase I inhibitor Exatecan (HY-13631). MC-VA-PAB-Exatecan synthesized ADC shows good antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2680543-57-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-147270. | |
| MC-VC-PABC-amide-PEG1-CH2-CC-885 | MC-VC-PABC-amide-PEG1-CH2-CC-885 (compound I-1) is a neoDegrader-Linker conjugate, consists of the GSPT1 degrader/molecular glue CC-885 (HY-101488) and a linker. MC-VC-PABC-amide-PEG1-CH2-CC-885 can be conjugated to the antibody DAR3.7 that specifically targets CD56 to synthesize Antibody-Drug Conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2722697-82-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145448. | |
| MC-VC-PABC-Aur0101 | MC-VC-PABC-Aur0101 is a agent-linker conjugate for ADC with potent antitumor activity by using Aur0101 (an auristatin microtubule inhibitor), linked via the ADC linker MC-VC-PABC. Uses: Scientific research. Category: Signaling pathways. CAS No. 1438849-92-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128955. | |
| MC-VC-PAB-NH2 TFA | MC-VC-PAB-NH2 TFA is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1616727-21-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-136132A. | |
| MC-VC-PAB-O-Gemcitabine | MC-VC-PAB-O-Gemcitabine is a linker-antibiotic intermediate, which is part of the antibody-antibiotic conjugate (AAC) molecule. MC-VC-PAB-O-Gemcitabine is conjugated with the linker and the antibiotic Gemcitabine (HY-17026). MC-VC-PAB-O-Gemcitabine can be used to study the immunotherapy of bacterial infections and the development of new antibacterial drugs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1639430-82-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-171414. | |
| Mc-VC-PAB-SN38 | Mc-VC-PAB-SN38 consists a cleavable ADC linker (Mc-VC-PAB) and a DNA topoisomerase I inhibitor (SN38). Mc-VC-PAB-SN38 can be used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1801838-28-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-131057. | |
| MC-VC-PAB-Tubulysin M | MC-vc-PAB-Tubulysin M is a Drug-Linker Conjugates for ADC, consisting of a microtubule polymerization inhibitor Tubulysin M (an ADC cytotoxin) (HY-N7053) and MC-vc-PAB (a cleavable ADC linker)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1639939-56-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-136313. | |
| MD-222 | MD-222 is the first-in-class highly potent PROTAC degrader of MDM2. MD-222 consists of ligands for Cereblon and MDM2. MD-222 induces rapid degradation of the MDM2 protein and activation of wild-type p53 in cells. MD-222 has anticancer effects[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2136246-72-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-134823. | |
| MD-224 | MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 consists of ligands for Cereblon and MDM2. MD-224 induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells, and achieves an IC50 value of 1.5 nM in inhibition of growth of RS4;11 cells. MD-224 has the potential to be a new class of anticancer agent[1]. MD-224 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2136247-12-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-114312. | |
| MD2-TLR4-IN-1 | MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex antagonist. MD2-TLR4-IN-1 inhibits Lipopolysaccharides (HY-D1056) (LPS)-induced expression of TNF-α and IL-6 in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. MD2-TLR4-IN-1 can be used for the study of acute lung injury (ALI)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2249801-12-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128598. | |
| MDH1/2-IN-1 | MDH1/2-IN-1 is a MDH1/2 inhibitor (IC50: 1.07 μM and 1.06 μM respectively). MDH1/2-IN-1 inhibits mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 demonstrates significant anti-tumor potential. MDH1/2-IN-1 provides a new direction for the development of drugs targeting cancer metabolism[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2143473-95-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W613220. | |
| MDH1-IN-1 | MDH1-IN-1 (Compound 5i) is a potent inhibitor of MDH1 with an IC50 of 6.79 μM. MDH1-IN-1 has the potential for the research of cancer diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2143463-31-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147790. | |
| MDH1-IN-2 | MDH1-IN-2 (Compound 7c) is a selective MDH1 inhibitor, with IC50 values of 2.27 and 27.47 μM for MDH1 and MDH2, respectively. MDH1-IN-2 can reduce the generation of ROS by inhibiting the conversion of 2-Ketoglutaric acid (HY-W013636) to α-Hydroxyglutaric acid (HY-113038B) mediated by MDH1, thereby suppressing 2-Ketoglutaric acid (HY-W013636)-induced ferroptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2143463-35-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147791. | |
| MDI-2268 | MDI-2268 is an inhibitor of plasma kallikrein inhibitor 1 (PAI-1). MDI-2268 has good antithrombotic properties and regulates blood coagulation and fibrinolysis process by enhancing fibrinolysis. MDI-2268 can be used in research areas such as deep vein thrombosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1609176-50-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124577. | |
| Mdivi-1 | Mdivi-1 is a selective dynamin-related protein 1 (Drp1) inhibitor. Mdivi-1 is a mitochondrial division/mitophagy inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Mitochondrial division inhibitor 1. CAS No. 338967-87-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-15886. | |
| MDL 105519 | MDL 105519 is a potent and selective antagonist of glycine binding to the NMDA receptor. Uses: Scientific research. Category: Signaling pathways. CAS No. 161230-88-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15085. | |
| MDL12330A | MDL12330A (RMI12330A) is an adenylyl cyclases inhibitor. MDL12330A can inhibit KV channels, increases insulin secretion and Ca2+ levels. MDL12330A accentuates contractions in uterine rings and inhibits cardiac functions. MDL12330A can be used for the research of endocrinology, metabolic and cardiovascular disease [1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RMI12330A. CAS No. 40297-09-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103192. | |
| MDL-28170 | MDL-28170 (Calpain Inhibitor III) is a potent, selective and membrane-permeable cysteine protease inhibitor of calpain that rapidly penetrates the blood-brain barrier following systemic administration[1][2]. MDL-28170 also block γ-secretase[4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Calpain Inhibitor III. CAS No. 88191-84-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18236. | |
| MDL-29951 | MDL-29951 is a novel glycine antagonist of NMDA receptor activation, with Ki of 0.14 μM for [3H]glycine binding in vitro and in vivo. Uses: Scientific research. Category: Signaling pathways. CAS No. 130798-51-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16312. | |
| MDL 72527 | MDL 72527 is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 shows a lysosomotropic effect. MDL 72527 shows neuroprotective effects[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 93565-01-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100621. | |
| MDL-800 | MDL-800 is an allosteric and selective SIRT6 activator. MDL-800 increases SIRT6 deacetylation activity with an EC50 of 10.3?μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2275619-53-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119376. | |
| MDL-811 | MDL-811 is a selective allosteric activator of SIRT6 with an EC50 of 5.7 μM. MDL-811 possesses anti-inflammatory, antitumor, and neuroprotective activities. MDL-811 can be used for the research of diseases such as colorectal cancer and ischemic stroke[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2275619-98-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156757. | |
| MDM2 ligand 5 | MDM2 ligand 5 is a Ligand for E3 Ligase that can be used for the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1410737-09-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130684. | |
| mDPR-Val-Cit-PAB-MMAE TFA | mDPR-Val-Cit-PAB-MMAE TFA is a drug-linker conjugate for ADC (Drug-Linker Conjugates for ADC), consisting of a tubulin polymerization inhibitor MMAE (HY-15162) and an ADC linker (peptide Val-Cit- PAB) composition[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2185872-76-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-19813A. | |
| ME-344 | ME-344 is an Isoflavone. ME-344 increases mitochondrial ROS generation. ME-344 inhibits tubulin polymerization. ME-344 inhibits HO-1 and impacts its mitochondrial translocation. ME-344 induces Apoptosis through Caspase 3 activation. ME-344 synergizes with Vinblastine in leukemia cells. ME-344 displays anti-tumor activity against leukemia and lung tumor. ME-344 can be used in the research of lung cancer, acute myeloid leukemia, and HER2-negative breast cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1374524-68-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112749. | |
| Mead acid methyl ester | Mead acid methyl ester is a kind of biochemical reagent. Uses: Scientific research. Category: Signaling pathways. CAS No. 14602-39-2. Pack Sizes: 1 mg (15.60 mM * 200 μL in Hexane); 5 mg (15.60 mM * 1 mL in Hexane). Product ID: HY-167562. | |
| MeAIB | MeAIB (α-(Methylamino)isobutyric acid) is a specific?substrate for amino acid transport system A (ATA1). ATA mediate the uptake of short-chain neutral amino acids in a Na+-dependent manner[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: α-(Methylamino)isobutyric acid. CAS No. 2566-34-9. Pack Sizes: 10 mM * 1 mL in Water; 250 mg. Product ID: HY-134452. | |
| Mebendazole | Mebendazole is a highly effective, broad-spectrum antihelmintic against nematode infestations. Mebendazole also exhibits inhibitory effect against glioblastoma multiforme (GBM), inhibits Hedgehog pathway and tubulin polymerization. Mebendazole is orally active and can cross CNS penetration[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 31431-39-7. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g. Product ID: HY-17595. | |
| Mebendazole-amine | Mebendazole-amine is a metabolite of Mebendazole (HY-17595). Mebendazole is a broad-spectrum benzimidazole anthelmintic[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 52329-60-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-114750. | |
| MeBIO | MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist, with IC50 of 44 μM (GSK-3) and 55 μM (CDK1/cyclin B), respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 667463-95-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103221. | |
| Mebrofenin | Mebrofenin (SQ 26962) is a type of iminodiacetic acid (IDA). Mebrofenin is available as a ready to use the kit for radio-labeling with Tc-99m. Tc-99m Mebrofenin, a diagnostic agent, is used for hepatobiliary imaging. Tc-99m Mebrofenin is the radiopharmaceutical of choice for the evaluation of hepatic function[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SQ 26962. CAS No. 78266-06-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1684. | |
| Mecamylamine hydrochloride | Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist. Mecamylamine hydrochloride is also a ganglionic blocker. Mecamylamine hydrochloride can across the blood-brain barrier. Mecamylamine hydrochloride can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area[1][2][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 826-39-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B1395. | |
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