MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Mal-PEG2-VCP-Eribulin | Mal-PEG2-VCP-Eribulin consists the ADCs linker (Mal-PEG2-VCP) and Eribulin (HY-13442). Eribulin is a mechanistically unique microtubule inhibitor and Eribulin inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Mal-PEG2-VCP-Eribulin is an Eribulin-based agent for antibody conjugates[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2130869-18-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-128870. |  |
| Mal-PEG3-NH2 TFA | Mal-PEG3-NH2 TFA is a linear heterobifunctional PEG reagent with a maleimide and an amine. Mal-PEG3-NH2 TFA is a crosslinking reagent with a PEG spacer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2830214-77-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W190796A. | |
| Mal-?PEG4-?NHS ester | Mal-PEG4-NHS ester is a non-cleavable ADC linker which links Quantum dots (QDs) with PEGylated liposomes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1325208-25-0. Pack Sizes: 50 mg; 100 mg; 250 mg; 1 g; 5 g. Product ID: HY-126505. | |
| Mal-PEG4-Val-Cit-PAB-PNP | Mal-PEG4-Val-Cit-PAB-PNP is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2112738-09-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-140145. | |
| Mal-PEG4-VA-PBD | Mal-PEG4-VA-PBD is a agent-linker conjugate for ADC by using the antitumor antibiotic, Pyrrolobenzodiazepine (PBD), linked via Mal-PEG4-VA. Uses: Scientific research. Category: Signaling pathways. CAS No. 1342820-68-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-126685. | |
| Mal-PEG4-VC-PAB-DMEA-PNU-159682 | Mal-PEG4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for ADC, consists the ADC linker Mal-PEG4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 includes metabolites of nemorubicin (MMDX) from liver microsomes and ADC cytotoxin PNU-159682[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2259318-52-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-126687. | |
| Mal-PEG5000-OH | Mal-PEG5000-OH can be used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolides poor water solubility and reduce its toxicity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Maleimide-PEG5000-Hydroxy. CAS No. 88504-24-9. Pack Sizes: 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-155902. | |
| Mal-PEG6-acid | Mal-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Uses: Scientific research. Category: Signaling pathways. CAS No. 518044-42-3. Pack Sizes: 100 mg; 250 mg; 1 g. Product ID: HY-126963. | |
| Mal-PEG6-mal | Mal-PEG6-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2752168-26-4. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-133353. | |
| Mal-PEG6-NHS ester | Mal-PEG6-NHS ester is a nonclaevable ADC linker containing a Maleimide group, 6-unit PEG and a NHS ester. Uses: Scientific research. Category: Signaling pathways. CAS No. 1599472-25-9. Pack Sizes: 100 mg; 250 mg; 1 g; 5 g. Product ID: HY-130085. | |
| Mal-PEG8-NHS ester | Mal-PEG8-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Uses: Scientific research. Category: Signaling pathways. CAS No. 2055033-05-9. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 1 g. Product ID: HY-126887. | |
| Mal-PEG8-Val-Ala-PAB-Exatecan | Mal-PEG8-Val-Ala-PAB-Exatecan (Compound 9b) is an antibody-drug conjugate linker (ADC linker) that binds to Nectin-4 polypeptides conjugated to chemotherapeutic agents. Mal-PEG8-Val-Ala-PAB-Exatecan can be used for cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2679821-39-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147271. | |
| Mal-PEG8-Val-Cit-PAB-MMAE | Mal-PEG8-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Mal-PEG8-Val-Cit-PAB-MMAE contains a cleavable ADC linker and a potent tubulin inhibitor MMAE (HY-15162)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3058970-85-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-141156. | |
| MALT1 inhibitor MI-2 | MALT1 inhibitor MI-2 is a MALT1 inhibitor (IC50=5.84 μM). MALT1 inhibitor MI-2 binds directly to MALT1, irreversibly suppresses protease function and is accompanied by NF-κB reporter activity suppression, c-REL nuclear localization inhibition, and NF-κB target gene downregulation. MALT1 inhibitor MI-2 shows nontoxic to animals[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1047953-91-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12276. | |
| Maltobionic acid | Maltobionic acid (4-O-α-D-Glucopyranosyl-D-gluconic acid) is an orally active oligosaccharide and iron chelator with antibacterial activity. Maltobionic acid inhibits the expression of NFATc1, suppresses osteoclast differentiation, inhibits bone resorption, and increases serum calcitonin levels. Maltobionic acid protects mammalian cells from hydrogen peroxide (H2O2)-induced oxidative damage; resists fermentation by the gut microbiota; and exhibits anti-digestive and anti-fermentative properties. Maltobionic acid can be used in research related to osteoporosis, bacterial infections, and constipation[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4-O-α-D-Glucopyranosyl-D-gluconic acid. CAS No. 534-42-9. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-W423191. | |
| Maltodextrin, dextrose equivalent 5.0-8.0 | Maltodextrin, dextrose equivalent 5.0-8.0 can be used as an excipient. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9050-36-6. Pack Sizes: 25 g; 50 g; 100 g. Product ID: HY-W250795B. | |
| Maltohexaose | Maltohexaose (Amylohexaose) is a linear oligosaccharide containing 6 glucose units, which can be produced from amylose, amylopectin, and whole starch. Maltohexaose can inhibit the proliferation of P-815 cells[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Amylohexaose. CAS No. 34620-77-4. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N2559. | |
| Maltol | Maltol, a type of aromatic compound, is an antioxidant agent. Maltol enhances neural function by mitigating oxidative stress and cell apoptosis. Maltol is an inhibitor of oxidative damage in nerve cells and is effective in preventing diabetic peripheral neuropathy (DPN). Maltol is used extensively as a safe flavoring agent and food preservative. Maltol is a metal ion chelator that can be used in the field of catalysis, cosmetics, and medicine[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 118-71-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-W012788. | |
| Maltopentaose | Maltopentaose is the shortest chain oligosaccharide. Maltopentaose is a substrate for α-amylases. Maltopentaose can be classified as maltodextrin and is also used in a study to investigate glycation and phosphorylation of α-lactalbumin. Maltopentaose is used to study the inhibition kinetics of human pancreatic α-amylase by dehydrodieugenol B[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Maltopentose. CAS No. 34620-76-3. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg. Product ID: HY-N1495. | |
| Maltose | Maltose is a disaccharide composed of two glucose molecules linked together. Maltose is an endogenous metabolic product in plants, yeast, or bacteria, and it participates in carbon source storage and metabolism. Maltose is a key core metabolite and main transport form in the temporary starch degradation, carbon output, and subsequent sucrose synthesis metabolism of the night chloroplast. In X. dendrorhous, maltose can act as a sugar donor and is converted into isomaltulose by α-glucosidase). Maltose can act as a osmotic agent, supporting continuous capillary ultrafiltration and preventing severe metabolic disorders[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 69-79-4. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g; 5 g. Product ID: HY-N2024. | |
| Maltotetraose | Maltotetraose can serve as a substrate for enzyme-linked assays to measure amylase activity in biological fluids. Maltotetraose has oral active, and reduces TNF-α-induced inflammatory responses by inhibiting NF-κB activity and decreasing ICAM-1 expression. Maltotetraose also inhibits PDGF-induced vascular smooth muscle cell migration and neovascularization. Additionally, Maltotetraose derivatives can function as probes for detecting bacterial infections by targeting the maltodextrin transporter. With good long-term safety, Maltotetraose holds promise for research in atherosclerosis-related diseases[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Amylotetraose; Fujioligo 450; α-1,4-Tetraglucose. CAS No. 34612-38-9. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2464. | |
| Maltotriitol | Maltotriitol is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Category: Signaling pathways. CAS No. 32860-62-1. Pack Sizes: 10 mM * 1 mL in Water; 10 mg; 25 mg. Product ID: HY-136656. | |
| Maltotriose | Maltotriose is a maltooligosaccharide and a specific inducer of the Escherichia coli maltose operon. The oligosaccharide structure of Maltotriose acts as a highly efficient drug delivery carrier, which significantly enhances the targeting ability and water solubility of photosensitizers in photodynamic therapy for pancreatic cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1109-28-0. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-113011. | |
| Mal-va-mac-SN38 | Mal-va-mac-SN38 is a drug-linker conjugate for ADC. Mal-va-mac-SN38 contains a ADC cytotoxin SN-38 (HY-13704) and a linker (HY-126364). Mal-va-mac-SN38 can rapidly and covalently bind with endogenous albumin in vivo, resulting in the formation of HSA-va-mac-SN38. Mal-va-mac-SN38 demonstrates exceptional stability in human plasma, and has anti-tumor and anti-metastasis effect[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2778229-31-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-159563. | |
| Mal-VC-PAB-DM1 | Mal-VC-PAB-DM1 is a agent-linker conjugate for ADC with potent antitumor activity by using DM1 (a potent microtubule-disrupting agent), linked via the ADC linker Mal-VC-PAB [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1464051-44-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126682. | |
| Mal-VC-PAB-DMEA-PNU-159682 | Mal-VC-PAB-DMEA-PNU-159682 is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-topoisomerase II agent, PNU-159682, linked via the lysosomally cleavable dipeptide, Mc-VC-PAB. Mal-VC-PAB-DMEA-PNU-159682 can be used in the synthesis of Anti-CD22-NMS249 (HY-164761)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SET0568. CAS No. 1178887-17-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-171138. | |
| Mal-VC-PAB-PNP | Mal-VC-PAB-PNP is a cleavable ADC linker. Mal-VC-PAB-PNP can be used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1096584-62-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148461. | |
| Malvidin-3-galactoside chloride | Malvidin-3-galactoside chloride, an anthocyanin monomer, induces hepatocellular carcinoma (HCC) cells cycle arrest and apoptosis. Malvidin-3-galactoside chloride inhibits the production and accumulation of ROS. Malvidin-3-galactoside chloride has anti-tumor function[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 30113-37-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N6623. | |
| Malvidin-3-glucoside chloride | Malvidin-3-glucoside (Malvidin-3-O-glucoside; Oenin) chloride is an orally active inhibitor of the NF-κB pathway, which blocks inflammatory responses induced by TNF-α, reduces IκB-α degradation and p65 nuclear translocation, and upregulates endothelial nitric oxide synthase eNOS to increase NO production. Malvidin-3-glucoside chloride exerts anti-inflammatory and antioxidant effects by inhibiting pro-inflammatory molecules such as MCP-1, ICAM-1, and IL-6, and regulating intestinal microorganisms and metabolites, while protecting endothelial cells and improving intestinal microecological dysbiosis under inflammatory conditions. Malvidin-3-glucoside chloride can be used to study chronic inflammatory-related diseases such as atherosclerosis and inflammatory bowel disease, and has the potential to prevent vascular inflammation and improve intestinal health[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Malvidin-3-O-glucoside chloride; Oenin chloride. CAS No. 7228-78-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-125740. | |
| Malvidin-3-O-arabinoside chloride | Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 28500-04-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N9349. | |
| Mancozeb | Mancozeb is a widely used fungicide that is effective against fungal diseases in most cereals, vegetables, fruits and ornamental plants. In addition, Mancozeb can cause liver damage in mice by activating the Keap1/Nrf2 signaling pathway. Mancozeb upregulates lactate dehydrogenase and cytochrome c to alter cell metabolism and induce cell death. Mancozeb has reproductive toxicity and can induce apoptosis in ovarian cells[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 8018-1-7. Pack Sizes: 100 mg; 500 mg; 1 g. Product ID: HY-B0854. | |
| Mandelic Acid-13C8 | Mandelic Acid-13C8 ((±)-Mandelic acid-13C8) is the 13C-labeled Mandelic acid (HY-W015591). Mandelic acid ((±)-Mandelic acid), an alpha-hydroxycarboxylic acid, has been widely used as an intermediate of pharmaceutical and fine chemicals. Mandelic acid shows antimicrobial activity and has been used for the research of urinary tract infections and vaginal trichomoniasis. Mandelic acid exhibits high sperm-immobilizing activity and low vaginal irritation[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (±)-Mandelic acid-13C8; DL-Mandelic acid-13C8. CAS No. 2701643-58-3. Pack Sizes: 1 mg. Product ID: HY-W654255. | |
| Mandipropamid | Mandipropamid displays outstanding activity against late blight diseases of potato and tomato, combined with excellent efficacy on downy mildew diseases of grape and cucumber[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 374726-62-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-W744966. | |
| Mangafodipir trisodium | Mangafodipir trisodium (MnDPDP), hepatocellular-specific contrast agent, is an efficacious inhibitor of CIPN (chemotherapy-induced peripheral neuropath) and other conditions caused by cellular oxidative stress. Mangafodipir trisodium shows no negative interference with the tumoricidal activity of chemotherapy[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MnDPDP. CAS No. 140678-14-4. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0993. | |
| Manganese chloride | Manganese chloride is an orally active MRI liver contrast agent. Manganese chloride induces Apoptosis and activates the mTOR signaling pathway. Manganese chloride induces cognitive impairment, promotes hematopoietic recovery, and reduces radiation-induced bone marrow and brain damage. It can be used for the study of renal impairment[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Manganese dichloride. CAS No. 7773-1-5. Pack Sizes: 10 mM * 1 mL in Water; 100 g; 500 g. Product ID: HY-W019894. | |
| Mangiferin (Standard) | Mangiferin (Standard) is the analytical standard of Mangiferin. This product is intended for research and analytical applications. Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4773-96-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0290R. | |
| Mannan | Mannan is an orally active polysaccharide compound that binds to the mannose receptor (MR). Mannan promotes bacterial uptake and endosomal degradation by binding to MR, thereby enhancing the production of IL-12 in immune cells. Mannan enhances ROS production. Mannan modulates immunity, inhibits Aflatoxin B1 (HY-N6615)-induced toxicity, and reduces lipid[1][2][3][4]. Uses: Scientific research. Category: Induced disease models products. CAS No. 9036-88-8. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W145667. | |
| Manninotriose | Manninotriose is a binder of dihydrofolate reductase and thymidylate synthase. Manninotriose binds to dihydrofolate reductase via hydrogen bond formation with Arg28. Manninotriose binds to thymidylate synthase via hydrogen bond formation with Arg50. Manninotriose acts as a membrane protectant and helps improve stress tolerance. Manninotriose can be used in research related to acute lymphoblastic leukemia[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 13382-86-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N0913. | |
| Manogepix | Manogepix (E1210) is a first-in-class, broad-spectrum and orally active antifungal. Manogepix has a mechanism of action-inhibition of fungal glycosylphosphatidylinositol (GPI) biosynthesis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: E1210; APX001A. CAS No. 936339-60-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18233. | |
| Manool | Manool is a diterpene from Salvia officinalis. Manool induces selective cytotoxicity in cancer cells. Manool arrests the cancer cells at the G(2)/M phase of the cell cycle[1][2]. Uses: Scientific research. Category: Natural products. CAS No. 596-85-0. Pack Sizes: 50 mg; 100 mg. Product ID: HY-N1039A. | |
| MANS peptide | MANS peptide is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 479482-23-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10218. | |
| Manumycin A | Manumycin A is a polyketide antibiotic and an inhibitor of thioredoxin reductase 1 (TrxR-1). Manumycin A can inhibit the growth of breast cancer cells and exert its anti-tumor activity through LC3. Manumycin A can downregulate the release of pro-inflammatory cytokines in human monocytes stimulated by TNF α, and has potential anti-inflammatory activity. Manumycin A can inhibit the Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration resistant prostate cancer cells to suppress exosome biogenesis and secretion[1][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 52665-74-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N6796. | |
| Manzamine A hydrochloride | Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Keramamine A hydrochloride. CAS No. 104264-80-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-117025A. | |
| MAO-B-IN-55 | MAO-B-IN-55 (Compound 5c) is a reversible competitive MAO-B inhibitor with an IC50 of 2.9 nM, and it exhibits approximately 2750-fold higher selectivity for MAO-B over MAO-A. MAO-B-IN-55 can be used for the research of Parkinson's disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1458219-02-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114620. | |
| MAO-IN-M30 dihydrochloride | MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible MAO-A (IC50=37 nM) and MAO-B (IC50=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent iron chelator and radical scavenger. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease[1][2][3]. MAO-IN-M30 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 64821-19-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131036. | |
| MAP4343 | MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 511-26-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107116. | |
| Mapatumumab | Mapatumumab (HGS-ETR1) is a fully human IgG1 agonistic monoclonal antibody that targets tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1). Mapatumumab can be used for the research of cancer[1]. Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: HGS-ETR1; Anti-Human TNFRSF10A Recombinant Antibody. CAS No. 658052-09-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99265. | |
| MAPK13-IN-1 | MPAK13-IN-1 is a MAPK13 (p38δ) inhibitor, with an IC50 of 620 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 229002-10-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18850. | |
| Maplirpacept | Maplirpacept (TTI-622; PF-07901801) is a fusion protein consisting of the CD47-binding domain of human SIRPα linked to the Fc region of human IgG4. Maplirpacept enhances phagocytosis by blocking CD47[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TTI-622; PF-07901801. CAS No. 2631667-06-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990707. | |
| Mapracorat | Mapracorat is a novel non-steroidal selective glucocorticoid receptor agonist. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ZK-245186; BOL-303242X. CAS No. 887375-26-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-14864. | |
| Maprotiline hydrochloride | Maprotiline hydrochloride is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects with oral activity. Maprotiline hydrochloride induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 10347-81-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B0444. | |
| Maraviroc | Maraviroc (UK-427857) is a selective CCR5 antagonist with activity against human HIV. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UK-427857. CAS No. 376348-65-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-13004. | |
| Marbofloxacin | Marbofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent, which has a broad spectrum bactericidal activity and good efficacy. Marbofloxacin can be used for the research of infections by Gram-positive and Gram-negative bacteria and Mycoplasma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 115550-35-1. Pack Sizes: 100 mg; 500 mg; 1 g. Product ID: HY-B0126. | |
| Mardepodect | Mardepodect is a potent, selective orally active, and brain-penetrant PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-2545920. CAS No. 898562-94-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-50098. | |
| Mardepodect hydrochloride | Mardepodect hydrochloride (PF-2545920 hydrochloride) is a potent, orally active and selective PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs. Mardepodect hydrochloride can cross the blood-brain barrier[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-2545920 hydrochloride. CAS No. 2070014-78-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50098A. | |
| Marein | Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC50 of 100 μM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 535-96-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N7676. | |
| Maresin 1 | Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1268720-28-0. Pack Sizes: 10 μg (277.4 μM * 100 μL in Ethanol); 25 μg (277.4 μM * 250 μL in Ethanol). Product ID: HY-116429. | |
| Margatoxin | Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 145808-47-5. Pack Sizes: 100 μg; 500 μg; 1 mg. Product ID: HY-P1280. | |
| Margetuximab | Margetuximab (MGAH22) is a chimeric anti-HER2 monoclonal antibody optimized Fc domain, with an EC50 value of 39.33 ng/mL. Margetuximab can be used for researching metastatic HER2-positive breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MGAH-22. CAS No. 1350624-75-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99030. | |
| Maridebart | Maridebart (AMG133 antibody) is a human immunoglobulin G1-kappa, anti-GIPR (gastric inhibitory polypeptide receptor) monoclonal antibody. Maridebart is the antibody portion of Maridebart cafraglutide (HY-164535) and can be used for the synthesis of antibody-drug conjugates (ADC). Maridebart can be used for the reserrch of obesity and type 2 diabetes [1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMG133 antibody. CAS No. 2761478-99-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990047. | |
| Maridebart cafraglutide | Maridebart cafraglutide (AMG 133) is a long-acting peptide-antibody conjugate that combines GLP-1 receptor agonist with glucose-dependent insulinotropic polypeptide (GIP) receptor antagonism. Maridebart cafraglutide shows antagonist activity against human, cynomolgus monkey and rat GIPR with IC50 values of 46.4 nM, 26.5 nM, 822.3 nM, respectively. Maridebart cafraglutide shows agonist activity against human, cynomolgus monkey, rat and mouse GLP-1R with EC50 values of 24.4 pM, 5.7 pM, 2.4 pM and 123 pM, respectively. Maridebart cafraglutide can be used for the study of obesity and type 2 diabetes[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMG 133. CAS No. 2887445-76-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-164535. | |
| Marimastat | Marimastat (BB2516) is a broad spectrum and orally bioavailable inhibitor of MMPs, with potent activity against MMP-9 (IC50=3 nM), MMP-1 (IC50=5 nM), MMP-2 (IC50=6 nM), MMP-14 (IC50=9 nM) and MMP-7 (IC50=13 nM), used in the treatment of cancer. Marimastat (BB2516) is an angiogenesis and metastasis inhibitor, which limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BB2516; TA2516. CAS No. 154039-60-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12169. | |
| Marizomib | Marizomib (Salinosporamide A) is a second-generation, irreversible, brain-penetrant, pan-proteasome inhibitor. Marizomib inhibits the CT-L (β5), CT-T-laspase-like (C-L, β1) and trypsin-like (T-L, β2) activities of the 20S proteasome (IC50=3.5, 28, and 430 nM, respectively)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Salinosporamide A; NPI-0052. CAS No. 437742-34-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 μg; 500 μg; 1 mg; 5 mg. Product ID: HY-10985. | |
| MARK-IN-1 | MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of <0.25 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1109283-93-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-101933. | |
| MARK-IN-2 | MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of 5 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1314893-26-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101934. | |
| Maropitant | Maropitant is an orally active NK1 receptor antagonist. Maropitant prevents vomiting and inhibits ulcerative dermatitis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 147116-67-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10053. | |
| Marrubiin | Marrubiin, isolated from Marrubium vulgare, exhibits vasorelaxant and antioedematogenic activity. Marrubiin alleviates diabetic symptoms in animals[1][2][3]. Uses: Scientific research. Category: Natural products. CAS No. 465-92-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N6995. | |
| Marstacimab | Marstacimab (PF-06741086) is an anti-tissue factor pathway inhibitor (TFPI) monoclonal antibody. Marstacimab can be used for the research of hemophilia[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-06741086. CAS No. 1985638-39-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P99725. | |
| MARY15 | MARY15 is a pyridinylpiperazine-based derivative of MARY1. MARY15 activates uncoupled mitochondrial respiration and upregulates p-AKT (S473) phosphorylation in renal proximal tubule cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3107758-65-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17684. | |
| Masitinib | Masitinib (AB1010) is a potent, orally bioavailable, and selective inhibitor of c-Kit (IC50=200 nM for human recombinant c-Kit). It also inhibits PDGFRα/β (IC50s=540/800 nM), Lyn (IC50= 510 nM for LynB), Lck, and, to a lesser extent, FGFR3 and FAK. Masitinib (AB1010) has anti-proliferative, pro-apoptotic activity and low toxicity[1][2][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AB1010. CAS No. 790299-79-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10209. | |
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