MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Maslinic acid | Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Crategolic acid; 2α-Hydroxyoleanolic acid. CAS No. 4373-41-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-N0629. |  |
| MASM7 | MASM7 is a mitofusin activator, and can achieve mitochondrial fusion via mitofusins. MASM7 can increase Mito AR with an EC50 value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN. MASM7 also demonstrates direct binding to the HR2 domain of MFN2 with Kd value of 1.1 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 920868-45-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W187305. | |
| Masofaniten | Masofaniten (Androgen receptor-IN-2) is a potent and orally active androgen receptor inhibitor. Masofaniten has antitumor activity against prostate cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Androgen receptor-IN-2. CAS No. 2416716-62-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136582. | |
| Masoprocol | Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active lipoxygenase inhibitor. Masoprocol shows antihyperglycemic activity. Masoprocol decreases the glucose concentration and hepatic triglyceride in vivo. Masoprocol has the potential for the research of type II diabetes[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: meso-Nordihydroguaiaretic acid; meso-NDGA. CAS No. 27686-84-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-109500. | |
| Massoia lactone | Massoia lactone ((±)-Massoia lactone) is a coconut and creamy fragrant compound mianly isolated from Cryptocarya massoy. Massoia lactone is also a fragrant biosurfactant produced by a fungus Aureobasidium pullulans[1]. Uses: Scientific research. Category: Natural products. Alternative Names: (±)-Massoia lactone. CAS No. 54814-64-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 5 g; 10 g; 25 g. Product ID: HY-N7435. | |
| MASTL-IN-2 | MASTL-IN-2 is an MASTL (microtubule-associated serine/threonine kinase-like) inhibitor. MASTL-IN-2 inhibits human epithelial MIA PaCa cancer cell proliferation with IC50 of 2.8 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3024916-69-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156716. | |
| MASTL-IN-4 | MASTL-IN-4(compound 70) is a potent MASTL inhibitor with a pIC50 value of 9.15. MASTL-IN-4 shows anti-proliferative activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2883041-36-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-162732. | |
| Mastoparan | Mastoparan, a tetradecapeptide which is a component of wasp venom, stimulates release of prolactin from cultured rat anterior pituitary cells. Uses: Scientific research. Category: Signaling pathways. CAS No. 72093-21-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0246. | |
| Matairesinol | Matairesinol is an orally active bioactive compound with anti-inflammatory, antioxidant and anticancer activities. Matairesinol inhibits the phosphorylation of MAPK, JNK and NF-κB, downregulates RANKL-induced NFATc1 expression and activity, and suppresses the activation of the PI3K/AKT/FOXO1 pathway. Matairesinol can be used in research related to sepsis-mediated brain injury, osteoporosis, heart failure, atopic dermatitis and cancer[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 580-72-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N3312. | |
| Matrine | Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI)[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Matridin-15-one; Vegard; α-Matrine. CAS No. 519-02-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg. Product ID: HY-N0164. | |
| Matuzumab | Matuzumab (EMD 72000) is a humanized anti-EGFR monoclonal antibody that blocks EGFR activation and downstream signaling, inhibits tumor growth. Deglycosylation and the possible elimination of ADCC activity can reduce the in vivo anti-tumor activity of Mattuzumab[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EMD 72000. CAS No. 339186-68-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9969. | |
| Mavacamten | Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MYK461; SAR439152. CAS No. 1642288-47-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109037. | |
| Mavacamten-d5 | Mavacamten-d5 (MYK461-d5; SAR439152-d5) is deuterium labeled Mavacamten (HY-109037). Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MYK461-d5; SAR439152-d5. CAS No. 2453251-00-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-109037S3. | |
| Mavacamten (Standard) | Mavacamten (Standard) is the analytical standard of Mavacamten. This product is intended for research and analytical applications. Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MYK461 (Standard); SAR439152 (Standard). CAS No. 1642288-47-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109037R. | |
| Mavatrep | Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (Ki=6.5 nM). Mavatrep antagonizes capsaicin-induced Ca2+ influx with an IC50 value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JNJ-39439335. CAS No. 956274-94-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16935. | |
| Mavodelpar | Mavodelpar (REN001) is a selective PPARδ agonist. Mavodelpar suppresses glomerular injury and renal fibrosis. Mavodelpar can be used for the research of primary mitochondrial myopathies (PMM) and long-chain fatty acid oxidation disorders (LC-FAOD)[1]. Mavodelpar is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: REN001; HPP593. CAS No. 1604815-32-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112597A. | |
| Mavoglurant | Mavoglurant (AFQ056) is a potent, selective, non-competitive and orally active mGluR5 antagonist, with an IC50 of 30 nM. Mavoglurant shows a >300 fold selectivity for the mGluR5 over all targets (238) tested. Mavoglurant can be used for the research of Fragile X syndrome (FXS), and L-dopa induced dyskinesias in Parkinson's disease[1][1][2]. Mavoglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AFQ056. CAS No. 543906-09-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-15257. | |
| Mavorixafor | Mavorixafor (AMD-070) is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 and 9 nM, respectively. Mavorixafor can be used for the study of WHIM syndrome[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMD-070; AMD-11070. CAS No. 558447-26-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50101. | |
| Mavorixafor hydrochloride | Mavorixafor (AMD-070) hydrochloride is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor hydrochloride also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 nM and 9 nM, respectively. Mavorixafor hydrochloride can be used for the study of WHIM syndrome[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMD-070 hydrochloride; AMD-11070 hydrochloride. CAS No. 880549-30-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50101C. | |
| Mavorixafor trihydrochloride | Mavorixafor trihydrochloride (AMD-070 trihydrochloride) is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 and 9 nM, respectively.Mavorixafor trihydrochloride can be used for the study of WHIM syndrome[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMD-070 trihydrochloride; AMD-11070 trihydrochloride. CAS No. 2309699-17-8. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50101A. | |
| Mavrilimumab | Mavrilimumab (CAM 3001) is a monoclonal antibody that binds to the α subunit of the granulocyte-macrophage colony stimulating factor (GM-CSF) receptor and blocks intracellular signalling downstream of GM-CSF. GM-CSF might be a mediator of the hyperactive inflammatory response associated with respiratory failure and death[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CAM 3001. CAS No. 1085337-57-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P99031. | |
| MAX1 | MAX1 is a self-assembling peptide used to prepare hydrogels[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 487036-63-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P10699. | |
| MAX-10181 | MAX-10181 (PD-1/PD-L1-IN-30) is a PD-1/PD-L1 binding inhibitor, with an IC50 value of 0.018 μM. MAX-10181 can be used for research of cancers and other related diseases[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PD-1/PD-L1-IN-30. CAS No. 2171558-14-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153064. | |
| Maxacalcitol | Maxacalcitol (22-Oxacalcitriol), a vitamin D3 (HY-15398) analog, is an orally active VDR agonist. Maxacalcitol has a limited calcemic effect. Maxacalcitol has the potential for psoriasis and hyperparathyroidism research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 22-Oxacalcitriol. CAS No. 103909-75-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-32339. | |
| Maxacalcitol-d6 | Maxacalcitol-d66 is the deuterated form of Maxacalcitol (22-Oxacalcitriol), which is a non-calcemic vitamin D3 analog and VDR ligand of VDR-like receptors. Uses: Scientific research. Category: Signaling pathways. CAS No. 2070009-38-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-15329. | |
| MAY0132 | MAY0132 is a potent and selective EPAC2 inhibitor with an IC50 of 0.4 μM. MAY0132 significantly inhibits replication of HMPV, AdV and RSV, reduces viral infection-induced cytokine/chemokine production, and inhibits NF-κB activation. MAY0132 has antiviral activity and can be used in the study of respiratory virus infection[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1895861-88-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138956. | |
| Maytansine | Maytansine is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC 153858. CAS No. 35846-53-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-13674. | |
| Maytansinol | Maytansinol (Ansamitocin P-0) is a derivative of Maytansine. Maytansinol can inhibit tubulin polymerization and induce apoptosis. Maytansinol has antitumor activity. Maytansinol can be used in cancer drug research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ansamitocin P-0. CAS No. 57103-68-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19474. | |
| MAZ51 | MAZ51 is a selective inhibitor of VEGFR-3 (Flt-4) tyrosine kinase. MAZ51 inhibits VEGF-C-induced activation of VEGFR-3 without blocking VEGF-C-mediated stimulation of VEGFR2. MAZ51 had no effect on ligand-induced autophosphorylation of EGFR, IGF-1R and PDGFRβ. MAZ51 blocks proliferation and induces apoptosis in a wide variety of tumor cells. Antitumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 163655-37-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116624. | |
| Mazdutide | Mazdutide (IBI-362; LY-3305677) is a long-acting synthetic oxyntomodulin analog. Mazdutide is also a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). Mazdutide binds human and mouse GCGR (Ki: 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki: 28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). Mazdutide is used in studies of obesity and type 2 diabetes (T2D)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IBI-362; LY-3305677; OXM-3. CAS No. 2259884-03-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P3375. | |
| Mazisotine | Mazisotine (CNTX-0290) is an orally active, non-opioid somatostatin receptor 4 (SSTR4) agonist with an EC50 of 4.7 nM. Mazisotine exerts significant analgesic effects in various nociceptive (inflammatory, osteoarthritic) and neuropathic pain models. Mazisotine can be used for pain research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY3556050; CNTX-0290. CAS No. 1638588-92-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139347. | |
| MB05032 | MB05032 is a special and efficacious gluconeogenesis inhibitor targeted the AMP binding site of fructose 1,6-bisphosphatase (FBPase) with an IC50 value of 16 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 261365-11-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16307. | |
| MB-07344 | MB-07344 is a potent thyroid hormone receptor (TR)-β agonist with a Ki of 2.17 nM. MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin (HY-B0589) in rabbits, dogs and monkeys[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 852947-39-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19513. | |
| MB-07811 | MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targeted thyroid hormone receptor-β agonist[1]. MB-07811 has cholesterol and triglycerides lowering activity[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VK-2809. CAS No. 852948-13-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-111288. | |
| MB710 | MB710, an aminobenzothiazole derivative, is a stabilizer of oncogenic p53 mutation Y220C. MB710 binds tightly to the Y220C pocket and stabilizes p53-Y220C, with a Kd of 4.1 μM. MB710 shows anticancer activity in p53-Y220C cell lines[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2230044-57-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-120373. | |
| MBA-m1 | MBA-m1 is a MLKL inhibitor. MBA-m1 inhibits necroptosis in Mlkl-/- NIH-3T3 cells. MBA-m1 ameliorates disease in MLKL-induced dermatitis and abdominal aortic aneurysm mouse model[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 305866-70-0. Pack Sizes: 1 mg. Product ID: HY-24504. | |
| m-BBIG dihydrochloride | m-BBIG dihydrochloride is a member of Bis-iminoguanidine (BIG) family and can be utilized in synthetic chemistry[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 181147-28-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-164652. | |
| MBCQ | MBCQ is a potent and selective cGMP-specific phosphodiesterase (PDE V; PDE5) inhibitor with an IC50 of 19 nM. MBCQ lacks inhibitory activity toward other PDE isozymes (all IC50s>100 μM). MBCQ dilates coronary arteries via specific inhibition of cGMP-PDE[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 150450-53-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-114672. | |
| MBD | MBD (7-(p-Methoxybenzylamino)-4-nitrobenz-2,1,3-oxadiazole), a new fluorescent probe for protein and nucleoprotein conformation, is applied to bacterial ribosomes and to bovine trypsinogen and trypsin. MBD is strongly fluorescent upon binding to a hydrophobic area of a macromolecule[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7-(p-Methoxybenzylamino)-4-nitrobenz-2,1,3-oxadiazole. CAS No. 33984-50-8. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-141667. | |
| MBM-55 | MBM-55 is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 1 nM. MBM-55 shows a 20-fold or greater selectivity in most kinases with the exception of RSK1 (IC50=5.4 nM) and DYRK1a (IC50=6.5 nM). MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2083622-09-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101029. | |
| MBP146-78 | MBP146-78 is a potent and selective inhibitor of cGMP dependent protein kinases. Uses: Scientific research. Category: Signaling pathways. CAS No. 188343-77-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101525. | |
| MBQ-167 | MBQ-167 is a dual Rac/Cdc42 inhibitor, with IC50s of 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 2097938-73-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112842. | |
| MBX-2982 | MBX-2982 is a selective, orally-available G protein-coupled receptor 119 (GPR119) agonist. Uses: Scientific research. Category: Signaling pathways. CAS No. 1037792-44-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15291. | |
| MC1568 | MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor, used for cancer research. Uses: Scientific research. Category: Signaling pathways. CAS No. 852475-26-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16914. | |
| MC180295 | MC180295 ((rel)-MC180295) is a potent and selective CDK9-Cyclin T1 inhibitor, with an IC50 of 5 nM, at least 22-fold more selective for CDK9 over other CDKs. MC180295 also inhibits GSK-3α and GSK-3β. MC180295 ((rel)-MC180295) has potent anti-tumor effect[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (rel)-MC180295. CAS No. 2237942-08-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119940. | |
| MC-1-F2 | MC-1-F2 is a FOXC2 inhibitor. MC-1-F2 shows a binding affinity (Kd) of 26 μM for full-length FOXC2. MC-1-F2 reduces epithelial-mesenchymal transition (EMT) markers in breast cancer cells, suppresses cancer stem cell (CSC) properties and reduces invasiveness in castration-resistant prostate cancer (CRPC) cells. MC-1-F2 can be used for the study of CRPC and breast cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2376894-10-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149894. | |
| MC3138 | MC3138 is a selective SIRT5 activator. MC3138 has antitumor activity on human PDAC cells, with IC50 values of 25.4-236.9 μM. MC3138 combined with Gemcitabine (HY-17026) significantly inhibits tumor growth in mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1844889-12-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160818. | |
| MC3482 | MC3482 is a specific sirtuin5 (SIRT5) inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 2922280-86-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112587. | |
| MC4171 | MC4171 (compound 34) is a selective KAT8 inhibitor (IC50=8.1 μM). MC4171 has been shown to exhibit moderate micromolar antiproliferative activity in different cancer cell lines, including NSCLC and AML, with potential for studying cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3034769-78-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153604. | |
| MC70 | MC70 is a potent and non-selective P-glycoprotein (P-gp) inhibitor with an EC50 of 0.69 μM. MC70 is an ABC transporters inhibitor and anticancer agent. MC70 interacts with ABCB1, ABCG2 and ABCC1[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1031367-64-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113805. | |
| MCA | MCA (7-Methoxycoumarin-4-acetic acid) is a Coumarin (HY-N0709) derivative. MCA quantitates platelet-activating factor (PAF) by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7-Methoxycoumarin-4-acetic acid. CAS No. 62935-72-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg. Product ID: HY-W027544. | |
| MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin | MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (compound 21a), a camptothecin payload, can be conjugated to a monoclonal antibody (mAb) for the synthesis of camptothecin antibody-drug conjugate (ADC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2414594-29-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132158. | |
| Mca-(ala7,lys(dnp)9)-bradykinin | Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The incorporation of a (7-methoxycoumarin-4-yl)acetyl (Mca) fluorescent group and a 2,4-dinitrophenyl (Dnp) quenching group has resulted in a large fluorescence increase upon substrate cleavage[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 323577-36-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3749. | |
| Mca-Ala-Pro-Lys(Dnp)-OH | Mca-Ala-Pro-Lys(Dnp)-OH, a specific ACE2 quenched fluorogenic substrate, can be used to detect ACE2 activity, such as urinary, heart and lung[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 305336-82-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2536. | |
| Mca-KPLGL-Dap(Dnp)-AR-NH2 | Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1[1]. (Ex/Em=325 nm/400 nm). Uses: Scientific research. Category: Signaling pathways. CAS No. 720710-69-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4931. | |
| MC-Ala-Ala-PAB | MC-Ala-Ala-PAB is a cleavable ADC linker. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1949793-44-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148464. | |
| Mca-PLAQAV-Dpa-RSSSR-NH2 | Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent substrate peptide that can be used to detect ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17). Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm; Em = 405 nm)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 192723-42-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3722. | |
| Mca-Pro-Leu-OH | Mca-Pro-Leu is a fluorescently labeled dipeptide[1]. Uses: Scientific research. Category: Peptides. Alternative Names: Mca-Pro-Leu. CAS No. 140430-55-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P4645. | |
| Mca-SEVNLDAEFK(Dnp)-NH2 | Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1802078-32-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4920. | |
| MCB-36 | MCB-36 is a VHL-recruiting pan-KRAS PROTAC degrader without affecting KRAS transcription. MCB-36 exhibits minimal effects on HRAS and NRAS protein levels. MCB-36 binds to the GDP-loaded state of G12D, G12C, G12V, and wild-type KRAS with high affinities Kd ? 1 pM). MCB-36 decreases p-ERK levels, leading to cell apoptosis. MCB-36 effectively suppress KRASG12C inhibitor-resistant cancer cells and remodel the tumor immune microenvironment. MCB-36 can be used for the study of colorectal cancer and lung cancer (Pink: Target protein ligand; Blue: E3 ligand (HY-112078); Black: Linker (HY-W091879))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3104382-00-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-176786. | |
| MCB-613 | MCB-613 is a potent Steroid receptor coactivator SRC small molecule stimulator (SMS), super-stimulates SRCs transcriptional activity.MCB-613 increases SRCs interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS).MCB-613 is a SMS that target oncogenes can be exploited as anti-cancer agents by over-stimulating the SRC oncogenic program[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1162656-22-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19625. | |
| MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-885 | MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-885 (Compound Ie) is a neodegrader conjugate, can be used in the synthesis of antibody neoDegrader conjugate (AnDC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2722697-86-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-160497. | |
| MC-betaglucuronide-MMAE-1 | MC-betaglucuronide-MMAE-1 is a agent-linker conjugate for ADC with potent antitumor activity by using MMAE (a tubulin polymerization inhibitor), linked via the cleavable ADC linker MC-betaglucuronide. Uses: Scientific research. Category: Signaling pathways. CAS No. 1703778-92-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136317. | |
| MCC950 | MCC950 (CP-456773; CRID3) is a potent and selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CP-456773; CRID3. CAS No. 210826-40-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-12815. | |
| MCC950 sodium | MCC950 sodium (CP-456773 sodium; CRID3 sodium salt) is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CP-456773 sodium; CRID3 sodium salt. CAS No. 256373-96-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-12815A. | |
| MCC-AAQ-Exa | MCC-AAQ-Exa is a drug-linker conjugates for ADC, obtained by condensing the linker with Exatecan (HY-13631) and can be used to prepare antibody-drug conjugates (ADCs). MCC is an ADC linker containing a maleimide fragment[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3052836-65-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-174279. | |
| MC-DM1 | MC-DM1 is a agent-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker MC to make antibody agent conjugate (ADC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1375089-56-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-136286. | |
| Mc-d-Val-d-Cit-PAB-PNP | Mc-d-Val-d-Cit-PAB-PNP is a cleavable ADC linker that can be used for synthesizing antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1350456-68-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-173161. | |
| MC-EVCit-PAB-MMAE | MC-EVCit-PAB-MMAE (Linker-Payload 11) is a drug-linker conjugates for ADC. MC-EVCit-PAB-MMAE contains the ADCs linker (MC-EVCit-PAB) and a potent tubulin polymerization inhibitor MMAE (HY-15162)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2873452-49-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-154915. | |
| MC-GGFG-AM-(10Me-11F-Camptothecin) | MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2873460-70-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-153360. | |
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