A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Also acts on 5-methylcytosine. Group: Enzymes. Synonyms: isocytosine deaminase. Enzyme Commission Number: EC 3.5.4.1. CAS No. 9025-5-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4536; cytosine deaminase; EC 3.5.4.1; 9025-05-2; isocytosine deaminase. Cat No: EXWM-4536.
Cytoskeletal Signaling Pathway Compound Library
A unique collection of 590 cytoskeleton-related compounds, can be used for HTS and HCS?. Uses: Scientific use. Product Category: L1310. Categories: Cytoskeletal Signaling Pathway Compounds Libraries.
cytosol alanyl aminopeptidase
A puromycin-sensitive, Co2+-activated zinc-sialoglycoprotein that is generally cytosolic. Multiple forms are widely distributed in mammalian tissues and body fluids. In peptidase family M1 (membrane alanyl aminopeptidase family). Group: Enzymes. Synonyms: arylamidase; aminopolypeptidase; thiol-activated aminopeptidase; human liver aminopeptidase; puromycin-sensitive aminopeptidase; soluble alanyl aminopeptidase; cytosol aminopeptidase III; alanine aminopeptidase. Enzyme Commission Number: EC 3.4.11.14. CAS No. 243859-94-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4010; cytosol alanyl aminopeptidase; EC 3.4.11.14; 243859-94-1; arylamidase; aminopolypeptidase; thiol-activated aminopeptidase; human liver aminopeptidase; puromycin-sensitive aminopeptidase; soluble alanyl aminopeptidase; cytosol aminopeptidase III; alanine aminopeptidase. Cat No: EXWM-4010.
Cytosolic 5'-nucleotidase II from Huamn, Recombinant
E.coli. Applications: Human cytosolic imp/gmp specific 5'-nucleotidase/phosphotransferase ii (cn-II) is a pure and active protein of 65kda cloned by rt-pcr amplification of mrna extracted from human hepatoma cells and expressed in e.coli. the sequence of the cloned nt5c2 gene (genbank accession number p49902) was confirmed by dna sequencing (100% identity). Group: Enzymes. Synonyms: uridine 5'-nucleotidase; 5'-adenylic phosphatase; adenosine 5'-phosphatase; AMP phosphatase; adenosine monophosphatase; 5'-mononucleotidase; AMPase; UMPase; snake venom 5'-nucleotidase; thimidine monophosphate nucleotidase; 5'-AMPase; 5'-AMP nucleotidase; AMP phosphohydrolase; IMP 5'-nucleotidase; EC 3. Enzyme Commission Number: EC 3.1.3.5. CAS No. 9027-73-0. AMPase. Mole weight: 65kDa. Activity: ≥ 0.150 unit/mg protein. Storage: -20 °C in a solution containing 50 mM Tris-HCl, pH 7.6, 2 mM β-mercaptoethanol, 50% glycerol. Source: Human. Species: cN-II. uridine 5'-nucleotidase; 5'-adenylic phosphatase; adenosine 5'-phosphatase; AMP phosphatase; adenosine monophosphatase; 5'-mononucleotidase; AMPase; UMPase; snake venom 5'-nucleotidase; thimidine monophosphate nucleotidase; 5'-AMPase; 5'-AMP nucleotidase; AMP phosphohydrolase; IMP 5'-nucleotidase; EC 3.1.3.5; CD73; NT5E; ecto-5'-nucleotidase. Pack: stable lyophilized form. Cat No: NATE-1742.
cytosol nonspecific dipeptidase
A zinc enzyme with broad specificity, varying somewhat with source species. Activated and stabilized by dithiothreitol and Mn2+. Inhibited by bestatin and leucine. Group: Enzymes. Synonyms: N2-β-alanylarginine dipeptidase; glycyl-glycine dipeptidase; glycyl-leucine dipeptidase; iminodipeptidase; peptidase A; Pro-X dipeptidase; prolinase; prolyl dipeptidase; prolylglycine dipeptidase; iminodipeptidase; prolinase; L-prolylglycine dipe. Enzyme Commission Number: EC 3.4.13.18. CAS No. 9025-31-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4032; cytosol nonspecific dipeptidase; EC 3.4.13.18; 9025-31-4; N2-β-alanylarginine dipeptidase; glycyl-glycine dipeptidase; glycyl-leucine dipeptidase; iminodipeptidase; peptidase A; Pro-X dipeptidase; prolinase; prolyl dipeptidase; prolylglycine dipeptidase; iminodipeptidase; prolinase; L-prolylglycine dipeptidase; prolylglycine dipeptidase; diglycinase; Gly-Leu hydrolase; glycyl-L-leucine dipeptidase; glycyl-L-leucine hydrolase; glycyl-L-leucine peptidase; L-amino-acyl-L-amino-acid hydrolase; glycylleucine peptidase; glycylleucine hydrolase; glycylleucine dipeptide hydrolase; non-specific dipeptidase; human cytosolic non-specific dipeptidase; glycyl-L-leucine hydrolase; glycyl-glycine dipeptidase. Cat No: EXWM-4032.
Cytosporin A
Cytosporin A is an angiotensin II receptor antagonist produced by Cytospora sp. Cytosporin A selectively inhibits the binding of angiotensin II to the AT2 site of the receptor with IC50 of 1.5-3.0 mol/L (0.5 to 1 μg/mL). Molecular formula: C17H24O5. Mole weight: 308.37.
Cytosporin B
Cytosporin B is a minor component produced by Cytospora sp. Molecular formula: C17H27ClO5. Mole weight: 346.85.
Cytosporin C
Cytosporin C is a minor component produced by Cytospora sp. Molecular formula: C17H26O5. Mole weight: 310.38.
Cytosporone B
Cytosporone B (Csn-B; Dothiorelone G) is a naturally occurring nuclear orphan receptor Nur77/NR4A1 agonist with an EC50 of 0.278 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Csn-B; Dothiorelone G. CAS No. 321661-62-5. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N2148.
Cytosporone B
Cytosporone B, also called as Csn-B or Dothiorelone G, is the first naturally nuclear orphan receptor Nur77 agonist with an EC50 of 0.278 nM. Synonyms: 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester; Cytosporone B, Csn-B. CAS No. 321661-62-5. Molecular formula: C18H26O5. Mole weight: 322.4.
Cytostatin
Cytostatin is a potent and selective inhibitor of protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), but it doesn't have effect against PP1, PP2B, or PP5. Synonyms: 2H-Pyran-2-one, 5,6-dihydro-6-[(1S,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrien-1-yl]-5-methyl-, (5S,6S)-; (5S,6S)-5,6-Dihydro-6-[(1S,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrien-1-yl]-5-methyl-2H-pyran-2-one; 2H-Pyran-2-one, 5,6-dihydro-6-[(1S,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrienyl]-5-methyl-, (5S,6S)-; (+)-Cytostatin; Antibiotic MJ 654NF4; NSC 675266. Grade: ≥75%. CAS No. 682329-63-1. Molecular formula: C21H33O7P. Mole weight: 428.46.
Cytostatin sodium salt
Cytostatin is a potent and selective inhibitor of protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), but it doesn't have effect against PP1, PP2B, or PP5. Synonyms: 2H-Pyran-2-one, 5,6-dihydro-6-[(1S,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrien-1-yl]-5-methyl-, sodium salt (1:1), (5S,6S)-; 2H-Pyran-2-one, 5,6-dihydro-6-[(1S,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrienyl]-5-methyl-, monosodium salt, (5S,6S)-; (+)-Cytostatin sodium salt; NSC 675266 sodium salt. Grade: ≥75%. CAS No. 457070-06-3. Molecular formula: C21H32NaO7P. Mole weight: 450.44.
Cytotoxic linear peptide
Cytotoxic linear peptide is an antibacterial peptide isolated from Pandinus cavimanus. Synonyms: NDBP-5; Phe-Leu-Gly-Gly-Leu-Trp-Lys-Ala-Met-Ser-Asn-Leu-Leu. Grade: 97.7%. Molecular formula: C69H108N16O16S. Mole weight: 1449.77.
Cytotoxic linear peptide IsCT
Cytotoxic linear peptide IsCT is a cationic antimicrobial peptide isolated from the venom of the scorpion Opisthacanthus madagascariensis that has a tendency to form an α-helical structure and shows potent antimicrobial activity and also inopportunely shows hemolytic effects. Synonyms: IsCT; Ile-Leu-Gly-Lys-Ile-Trp-Glu-Gly-Ile-Lys-Ser-Leu-Phe-NH2. Grade: 96.0%. Molecular formula: C74H119N17O16. Mole weight: 1502.8.
Cytotoxic linear peptide IsCT2
Cytotoxic linear peptide IsCT2 is an antibacterial peptide isolated from Opisthacanthus madagascariensis (Scorpion). It has activity against gram-positive bacteria and gram-negative bacteria. Synonyms: Ile-Phe-Gly-Ala-Ile-Trp-Asn-Gly-Ile-Lys-Ser. Grade: 95.7%. Molecular formula: C58H88N14O14. Mole weight: 1205.4.
Cytotoxic linear peptide IsCT precursor
Cytotoxic linear peptide IsCT precursor is a cationic antimicrobial peptide, which has activity against gram-positive bacteria and gram-negative bacteria. Synonyms: [K7, P8, K11]-IsCT; Ile-Leu-Gly-Lys-Ile-Trp-Lys-Ile-Lys-Lys-Leu-Phe-NH2. Grade: 97.7%. Molecular formula: C76H128N18O12. Mole weight: 1485.97.
Cytovaricin
Cytovaricin is an antibiotic produced by Streptomyces sp. H-230 and Str. collinus H-230. It has the activity of inhibiting Yoshida sarcoma cells and has weak anti-phytopathogenic fungi and chlorella activity. CAS No. 79553-45-0. Molecular formula: C47H80O16. Mole weight: 901.13.
Cytovaricin B
Cytovaricin B is a Janus kinase-signal transducer and activation protein (JAK-STAT) inhibitor produced by Streptamyces torulosus 3197-GM1. CAS No. 129985-88-2. Molecular formula: C48H82O16. Mole weight: 915.15.
Cytoxazone
Cytoxazone is a cytokine regulator produced by Streptornyces sp. RK95-31. It inhibits the production of IL-4 and IL-10 induced by Pokeween mitogen (PWM) at 6.25-25 μg/mL, but does not inhibit the production of GM-CSF induced by PWM. Synonyms: (-)-Cytoxazone. Grade: >98%. CAS No. 42902-32-9. Molecular formula: C11H13NO4. Mole weight: 223.22.
CYY292
CYY292 is an FGFR1 inhibitor that specifically targets the FGFR1/AKT/Snail pathway in GBM cells. CYY292 dose-dependently inhibits cancer cell proliferation, epithelial-mesenchymal transition, stemness, invasion, and migration in vitro[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2644673-04-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-162153.
CZ415
CZ415 is a potent and highly selective mTOR inhibitor with a pIC50 of 8.07. CZ415 inhibits mTORC1 and mTORC2 protein complex. Uses: Scientific research. Category: Signaling pathways. CAS No. 1429639-50-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100222.
CZ415
CZ415 is a highly selective potent mTOR inhibitor with little activity on other lipid and protein kinases with efficacy in a collagen induced arthritis model and exhibits excellent cell permeability. In the issue, Bergamini et al., who has identified CZ415, confirmed with its extraordinary selectivity, drug-like properties and proven efficacy in vivo, CZ415 represents an ideal molecule for the pharmacological investigation of mTOR pathophysiological role in vivo. Assessed in dose response format from HEK293T cells after treatment with CZ415: 1. inhibition of S6RP (downstream of mTORC1) phosphorylation in HEK293T: IC50 = 14.5 nM; 2. inhibition of Akt (mTORC2 substrate) phosphorylation in HEK293T: IC50 = 14.8 nM; 3. inhibition of IFNγ release in stimulated human whole blood: IC50 = 226 nM. Synonyms: CZ415; CZ-415; CZ 415; (S)-1-(4-(7,7-dimethyl-4-(3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea. CAS No. 1429639-50-8. Molecular formula: C22H29N5O4S. Mole weight: 459.57.
CZC24832 is the first selective inhibitor of phosphoinositide 3-kinase γ (PI3Kγ) with efficacy in in vitro and in vivo models of inflammation. Extensive target- and cell-based profiling of CZC24832 revealed regulation of interleukin-17-producing T helper cell (T(H)17) differentiation by PI3Kγ, thus reinforcing selective inhibition of PI3Kγ as a potential treatment for inflammatory and autoimmune diseases. Synonyms: CZC24832; CZC-24832; CZC 24832. Grade: 0.98. CAS No. 1159824-67-5. Molecular formula: C15H17FN6O2S. Mole weight: 364.399.
CZC-25146
CZC-25146 is a compound that acts as an inhibitor of LRRK2, a factor in the expression of Parkinsons. Synonyms: CZC25146; CZC 25146. Grade: >98%. CAS No. 1191911-26-8. Molecular formula: C22H25FN6O4S. Mole weight: 488.54.
CZC-25146 hydrochloride
CZC-25146 is a compound that acts as an inhibitor of LRRK2, a factor in the expression of Parkinsons's disease, and is ATP-competitive. Synonyms: CZC25146 hydrochloride; CZC 25146 hydrochloride. Grade: 0.98. CAS No. 1330003-04-7. Molecular formula: C22H26ClFN6O4S. Mole weight: 524.996.
CZC-54252
Potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC50 values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). Attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM). Synonyms: CZC-54252; CZC 54252; CZC54252. Grade: >98%. CAS No. 1191911-27-9. Molecular formula: C22H25ClN6O4S. Mole weight: 504.99.
CZC 54252 hydrochloride
CZC 54252 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1191911-27-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
CZC-54252 hydrochloride
CZC-54252 hydrochloride is a potent and selective inhibitor of LRRK2 with IC50s of 1.28 and 1.85 nM for wild-type and G2019S LRRK2, respectively. G2019S LRRK2-induced human neuronal injury is attenuated by CZC-54252 hydrochloride with an EC50 of ~1 nM. It has a neuroprotective activity. Synonyms: Methanesulfonamide, N-[2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-, hydrochloride (1:1); N-[2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide hydrochloride. Grade: ≥95%. CAS No. 1784253-05-9. Molecular formula: C22H26Cl2N6O4S. Mole weight: 541.45.
CZC-8004
CZC-8004 is an aminopyrimidine which is a pan-kinase inhibitor that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES. Synonyms: Dianilinopyrimidine-01; CZC-00008004. Grade: ≥98%. CAS No. 916603-07-1. Molecular formula: C17H16FN5. Mole weight: 309.3.
CzSi
CzSi. Alternative Names: 9-(4-tert-Butylphenyl)-3,6-bis(triphenylsilyl)-9H-carbazole,9-[4-(1,1-Dimethylethyl)phenyl]-3,6-bis(triphenylsilyl)-9H-carbazole. CAS No. 898546-82-2. Molecular formula: C58H49NSi2. Mole weight: 816.19. IUPAC Name: [9-(4-tert-butylphenyl)-6-triphenylsilylcarbazol-3-yl]-triphenylsilane. SMILES: CC(C)(C)C1=CC=C(C=C1)N2C3=C(C=C(C=C3)[Si](C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)C7=C2C=CC(=C7)[Si](C8=CC=CC=C8)(C9=CC=CC=C9)C1=CC=CC=C1. InChI: InChI=1S/C58H49NSi2/c1-58(2,3)44-34-36-45(37-35-44)59-56-40-38-52(60(46-22-10-4-11-23-46,47-24-12-5-13-25-47)48-26-14-6-15-27-48)42-54(56)55-43-53(39-41-57(55)59)61(49-28-16-7-17-29-49,50-30-18-8-19-31-50)51-32-20-9-21-33-51/h4-43H,1-3H3.