A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
E0199 is a novel potent dual-target KV7/NaV modulator that activates the KV7 channel (KV7.2/7.3 (EC50 = 12.78 nM), KV7.2 (EC50 = 0.50 μM), and KV7.5 (EC50 = 27.14 nM) channels) while simultaneously blocks the NaV1.7 (IC50 = 0.52 μM), NaV1.8 (IC50 = 0.24 μM), and NaV1.9 (IC50 = 0.16 μM) channels. E0199 shows a potent analgesic effect without affecting heart and skeletal muscle ion channels critically in a chronic constriction injury (CCI) mouse model. E0199 can be used for Neuropathic pain (NP) research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 931928-13-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-178281.
E-0-(3-chloro-2-propyenyl)hydroxylamine HCl
(3-chloro-2-propyenyl)hydroxylamine HCl. CAS No. 96992-71-1. Categories: (e)-o-(3-chloroallyl)hydroxylamine hydrochloride.
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E07LKK
E07LKK has antibacterial activity against S. aureus, E.coli.
E104
E104 (compound 1) is a potent and selective TLR7 agonist. E104 can be delivered by antibody-drug conjugate (ADC) technology to elicit potent anticancer activity. E104 induces the activation of mouse macrophages and hPBMCs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1610431-21-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156174.
E10KKL
E10KKL is a synthetic construct peptide. It has antibacterial activity.
E1231
E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC50=0.83 μM). E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression. Synonyms: 1-{4-[2-(5-methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one. CAS No. 1031195-19-3. Molecular formula: C21H21N3O3. Mole weight: 363.41.
E12LLK
E12LLK is a synthetic construct peptide. It has antibacterial activity.
E14KKL
E14KKL is a synthetic construct peptide. It has antibacterial activity.
E14LKK / H14LKK
E14LKK / H14LKK is a synthetic construct peptide. It has antibacterial activity.
E17110
E17110 is an LXRβ agonist. E17110 shows a significant activation effect on LXRβ, with an EC50 of 0.72 μmol/L. Synonyms: E-17110; E 17110. Grade: ≥98% by HPLC. Molecular formula: C16H15FN2O5. Mole weight: 334.30.
E1R
E1R is a positive allosteric modulator of sigma-1 receptors (Sig1R PAM) with cognition-enhancing activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1301211-78-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116463.
E1 ubiquitin-activating enzyme
Catalyses the ATP-dependent activation of ubiquitin through the formation of a thioester bond between the C-terminal glycine of ubiquitin and the sulfhydryl side group of a cysteine residue in the E1 protein. The two-step reaction consists of the ATP-dependent formation of an E1-ubiquitin adenylate intermediate in which the C-terminal glycine of ubiquitin is bound to AMP via an acyl-phosphate linkage, then followed by the conversion to an E1-ubiquitin thioester bond via the cysteine residue on E1 in the second step. Group: Enzymes. Synonyms: ubiquitin activating enzyme; E1; ubiquitin-activating enzyme E1. Enzyme Commission Number: EC 6.2.1.45. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5704; E1 ubiquitin-activating enzyme; EC 6.2.1.45; ubiquitin activating enzyme; E1; ubiquitin-activating enzyme E1. Cat No: EXWM-5704.
E 2012
E 2012, is a potent selective, orally bioavailable γ-secretase modulator without affecting Notch processing that can used to treat Alzheimer's Disease. Synonyms: (3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]piperidin-2-one; 870843-42-8; E 2012; (E)-1-[(1S)-1-(4-FLUOROPHENYL)ETHYL]-3-[3-METHOXY-4-(4-METHYL-1H-IMIDAZOL-1-YL)BENZYLIDENE]PIPERIDIN-2-ONE; UNII-3LSD4Y5F0F; 3LSD4Y5F0F; CHEMBL1224151; E-2012; (e)-1-((1s)-1-(4-fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1h-imidazol-1-yl)benzylidene)piperidin-2-one; (3E)-1-((1S)-1-(4-Fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one; (3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]piperidin-2-one; GTPL7358; SCHEMBL1238634; SCHEMBL1238639; C25H26FN3O2; DTXSID30468614; PUOAETJYKQITMO-LANLRWRYSA-N; (S,E)-1-(1-(4-fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one; W-5462; J-501810; I14-15434; (3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylene]piperidin-2-one; 2-Piperidinone, 1-((1S)-1-(4-fluorophenyl)ethyl)-3-((3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)methylene)-, (3E)-. CAS No. 870843-42-8. Molecular formula: C25H26FN3O2. Mole weight: 419.49.
E 2012
E 2012 is a potent gamma (γ) secretase modulator without affecting Notch processing. E 2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 870843-42-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10016.
E260 is a Fer/FerT kinase inhibitor with Kd of 0.85 uM, which selectively evokes metabolic stress and necrotic death in cancer cells. Synonyms: E260; E 260; E-260; 2-[4-[(4-methylpiperazin-1-yl)methyl]piperidin-1-yl]-6-(4-propan-2-ylphenyl)imidazo[2,1-b][1,3,4]thiadiazole. CAS No. 1241537-79-0. Molecular formula: C24H34N6S. Mole weight: 438.638.
E260
E260 is a Fer/FerT kinase inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 1241537-79-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112097.
e-2,6-Dichloro-3-(2-nitro)vinylquinoline
e-2,6-Dichloro-3-(2-nitro)vinylquinoline. Alternative Names: E-2,6-Dichloro-3-(2-nitro)vinylquinoline, 182050-35-7, CTK4D8041, AG-E-31885. CAS No. 182050-35-7. Purity: 96%. Product ID: ACM182050357. Molecular formula: C11H6Cl2N2O2. Mole weight: 269.08. IUPAC Name: 2,6-dichloro-3-(2-nitroethenyl)quinoline. Alfa Chemistry - ISO 9001:32057 Certified.
e-2,6-Dichloro-8-methyl-3-(2-nitro)vinylquinoline
e-2,6-Dichloro-8-methyl-3-(2-nitro)vinylquinoline. Alternative Names: E-2,6-Dichloro-8-methyl-3-(2-nitro)vinylquinoline, 1031929-44-8, CTK4A1849, AG-D-13616. CAS No. 1031929-44-8. Purity: 96%. Product ID: ACM1031929448. Molecular formula: C12H8Cl2N2O2. Mole weight: 283.11. IUPAC Name: 2,6-dichloro-8-methyl-3-(2-nitroethenyl)quinoline. Alfa Chemistry - ISO 9001:32057 Certified.
The E2 ubiquitin-conjugating enzyme acquires the activated ubquitin from the E1 ubiquitin-activating enzyme (EC 6.2.1.45) and binds it via a transthioesterification reaction to itself. In the human enzyme the catalytic center is located at Cys-87 where ubiquitin is bound via its C-terminal glycine in a thioester linkage. Group: Enzymes. Synonyms: ubiquitin-carrier-protein E2; UBC (ambiguous); ubiquitin-conjugating enzyme E2. Enzyme Commission Number: EC 2.3.2.23. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2297; E2 ubiquitin-conjugating enzyme; EC 2.3.2.23; ubiquitin-carrier-protein E2; UBC (ambiguous); ubiquitin-conjugating enzyme E2. Cat No: EXWM-2297.
E3330
E3330 is a potent and selective APE1 (Ref-1) inhibitor, which inhibits NF-κB DNA-binding activity. It blocks TNF-α-induced activation of IL-8 production in liver cancer cell lines and has anticancer properties such as inhibiting the growth and migration of cancer cells. Synonyms: APX-3330; E-3330; E 3330; (2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid; (E)-2-((4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylene)undecanoic acid; Undecanoic acid, 2-((4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene)-, (E)-. Grade: 98%. CAS No. 136164-66-4. Molecular formula: C21H30O6. Mole weight: 378.46.
E 3810 dihydrochloride
E 3810 dihydrochloride is a dual VEGFR/FGFR tyrosine kinase inhibitor. It suppresses the tumor angiogenesis and tumor cell proliferation via inhibiting VEGFR1, -2, and -3 and FGFR-1 and -2 kinases in the nanomolar range. Uses: Antitumor agent. Synonyms: E 3810 dihydrochloride; E3810 dihydrochloride; E-3810 dihydrochloride; Lucitanib dihydrochloride; 6-[7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl]oxy-N-methylnaphthalene-1-carboxamide dihydrochloride. Grade: 99%. CAS No. 2108875-91-6. Molecular formula: C26H25N3O4.2HCl. Mole weight: 516.42.
E3 ligase Ligand 32
E3 ligase Ligand 32 (First product in Example 3) is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 32 can be connected to the ligand for protein by a linker to form PROTACs and can be used for the synthesis of PROTAC SMARCA2/4-degrader-29 (HY-162743)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2300099-98-1. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W382038.
E3 ligase Ligand 51
E3 ligase Ligand 51 is the ligand for E3 ligase CRBN that can be used for synthesis of PROTAC BTK Degrader-12 (HY-170413)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2703915-71-1. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-W245311.
E3 ligase Ligand 56
E3 ligase Ligand 56 is the ligand for E3 ligase Cereblon and can be used for syntheisis of PROTAC CDK9 degrader-11 (HY-170978)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1472731-41-1. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W247437.
E3 ligase Ligand-Linker Conjugates 30
E3 ligase Ligand-Linker Conjugates 30 incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 30 can be used to design PROTAC MDM2 degrade. Synonyms: 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; Pomalidomide-PEG3-C2-NH2; SCHEMBL19451340; BCP33441; HY-128716; CS-0099510; Cereblon Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 30. Grade: > 98%. CAS No. 2093416-31-8. Molecular formula: C21H28N4O7. Mole weight: 448.47.
E3 ligase Ligand PG
E3 ligase Ligand PG is a E3 ligase ligand that can be used in the recruitment of CRBN protein. E3 ligase Ligand PG exhibits potent binding activity with CRBN (IC50 of 2.191 μM). E3 ligase Ligand PG can be connected to the BMS-202 (HY-19745) by a linker to form PROTAC, PROTAC PD-L1 degrader-1 (HY-163757)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 14149-34-9. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-150839.
E3 ubiquitin-protein ligase Mdm2 (53-60)
E3 ubiquitin-protein ligase Mdm2 (53-60) is a peptide derived from E3 ubiquitin-protein ligase Mdm2. The E3 ubiquitin-protein ligase MDM2 is a novel interactor of the von Hippel-Lindau tumor suppressor. Synonyms: Double minute 2 protein (53-60); RING-type E3 ubiquitin transferase Mdm2 (53-60); p53-binding protein Mdm2 (53-60).
E3 ubiquitin-protein ligase RNF43 (11-19(20))
A peptide fragment of E3 ubiquitin-protein ligase RNF43. E3 ubiquitin-protein ligase acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Synonyms: RING finger protein 43 (11-19(20)); RING-type E3 ubiquitin transferase RNF43 (11-19(20)).
E3 ubiquitin-protein ligase RNF43 (721-729)
A peptide fragment of E3 ubiquitin-protein ligase RNF43. E3 ubiquitin-protein ligase acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Synonyms: RING finger protein 43 (721-729); RING-type E3 ubiquitin transferase RNF43 (721-729).
E3 ubiquitin-protein ligase UBR4 (329-337)
E3 ubiquitin-protein ligase UBR4 (329-337) is a peptide derived from E3 ubiquitin-protein ligase UBR4. E3 ubiquitin-protein ligase is a component of the N-end rule pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Synonyms: RING-type E3 ubiquitin transferase UBR4 (329-337); Retinoblastoma-associated factor of 600 kDa (329-337).
E3,Z8,Z11-Tetradecatriene acetate
E3,Z8,Z11-Tetradecatriene acetate. CAS No. 163041-94-9. Cenik is your partner of choice for specialised chemicals. We don't just provide products - we supply solutions to your technical and regulatory specifications.
E-4031
E-4031 is a selective hERG potassium channel blocker for use in class III anti-arrhythmic studies[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 113559-13-0. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15551.
E-4031
E-4031, a benzenesulfonamide derivative, could be used as a Class III antiarrhythmic agent due to its effect of blocking the ERG potassium channels. Uses: E-4031 could be used as a class iii antiarrhythmic agent due to its effect of blocking the erg potassium channels. Synonyms: E-4031; E 4031; E4031; 113559-13-0; CHEMBL536480; E-4031dihydrochloride; E-4031; 1-(2-(6-Methyl-2-pyridyl)ethyl)-4-(4-methylsulfonylaminobenzoyl)piperidinedihydrochloride; N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamidedihydrochloride. Grade: 95%. CAS No. 113559-13-0. Molecular formula: C21H29Cl2N3O3S. Mole weight: 474.44.
E-4031 dihydrochloride
E-4031 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 113559-13-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
E4CPG
E4CPG. Group: Biochemicals. Grades: Purified. CAS No. 170846-89-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
E4CPG
E4CPG is a group I/group II metabotropic glutamate receptor antagonist with higher potency than (RS)-MCPG. Synonyms: (RS)-α-Ethyl-4-carboxyphenylglycine; 4-(1-amino-1-carboxypropyl)benzoic acid. Grade: ≥99% by HPLC. CAS No. 170846-89-6. Molecular formula: C11H13NO4. Mole weight: 223.23.
E-5-(2-Carboxyvinyl)-2'-deoxyuridine hydroxysuccinimide ester. Group: Biochemicals. Grades: Highly Purified. CAS No. 869355-24-8. Pack Sizes: 100mg, 200mg, 500mg, 1g. Molecular Formula: C16H17N3O9. US Biological Life Sciences.
Worldwide
E-5-(2-Carboxyvinyl)uracil
E-5-(2-Carboxyvinyl)uracil. Group: Biochemicals. Grades: Highly Purified. CAS No. 57412-59-6. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. US Biological Life Sciences.
Worldwide
E 5555 hydrobromide
E 5555 hydrobromide is a potent and orally bioactive thrombin receptor (or protease-activated receptor 1, PAR1) antagonist (IC50 = 19 nM). It inhibits human platelet aggregation induced by thrombin and TRAP with IC50 values of 64 and 31nM, respectively. Synonyms: Atopaxar hydrobromide; ER 172594-06 HBr; E 5555 hydrobromide; E-5555 hydrobromide; E5555 hydrobromide. Grade: 99%. CAS No. 474550-69-1. Molecular formula: C29H38FN3O5.HBr. Mole weight: 608.54.
E-5-Bromo-2-chloro-6-methoxy-3-(2-nitro)vinylquinoline. Alternative Names: E-5-Bromo-2-chloro-6-methoxy-3-(2-nitro)vinylquinoline, 1031929-45-9, CTK4A1850, AG-D-13617. CAS No. 1031929-45-9. Purity: 96%. Product ID: ACM1031929459. Molecular formula: C12H8BrClN2O3. Mole weight: 343.56. IUPAC Name: 5-bromo-2-chloro-6-methoxy-3-(2-nitroethenyl)quinoline. Alfa Chemistry - ISO 9001:32057 Certified.
E6130
E6130 is an orally active and highly selective CX3CR1 modulator, that may be effective for treatment of inflammatory bowel disease. Uses: Scientific research. Category: Signaling pathways. CAS No. 1427058-33-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-107456.