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| Product | Description | |
|---|---|---|
| E6201 | E6201 is a synthetic, fungal metabolite analogue inhibitor of mitogen-activated protein kinase kinase 1 (MEK-1) and mitogen-activated protein kinase kinase kinase 1 (MEKK-1) with potential antipsoriatic and antineoplastic activities. MEK-1/MEKK-1 inhibitor E6201 specifically binds to and inhibits the activities of MEK-1 and MEKK-1, which may result in the inhibition of tumor cell proliferation. MEK-1 and MEKK-1 are key components in the RAS/RAF/MEK/MAPK signaling pathway, which regulates cell proliferation and is frequently activated in human cancers. Synonyms: E6201; E 6201; E-6201; ER 806201; ER806201; ER-806201; LL-Z1640-2. CAS No. 603987-35-5. Molecular formula: C21H27NO6. Mole weight: 389.45. |  |
| E6-272 | E6-272 is a human papillomavirus 16 (HPV 16) inhibitor. E6-272 induces Apoptosis. E6-272 inhibits the proliferation of HPV-positive cells. E6-272 can be used in the research of cervical cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 945142-65-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-163901. |  |
| E-64 | E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain. Uses: For research used only. Synonyms: L-trans-Epoxysuccinyl-Leu-4-guanidinobutylamide; Proteinase inhibitor E 64; 3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-(2S,3S)-oxiranecarboxylic acid; Thiol protease inhibitor; trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane; 2-Oxiranecarboxylic acid, 3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, (2S,3S)-; L-Trans-Epoxysuccinyl-Leu-agmatine. Grade: ≥99% by HPLC. CAS No. 66701-25-5. Molecular formula: C15H27N5O5. Mole weight: 357.41. | |
| E-64 | E-64 is an irreversible and selective cysteine protease inhibitor, and also inhibits papain, calpain, and cathepsins B and H, but not serine proteases or aspartic proteases. The IC50 for papain is 9 nM. E-64 induces oxidative stress and apoptosis in Filarial Parasite. Group: Inhibitors. CAS No. 66701-25-5. Pack Sizes: 10mg. Product ID: S7379. Formula: C15H27N5O5. Smiles: CC(C)CC(C(=O)NCCCCN=C(N)N)NC(=O)C1C(O1)C(=O)O. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| E-64 | 5mg Pack Size. Group: Analytical Reagents, Biochemicals. Formula: C15H27N5O5. CAS No. 66701-25-5. Prepack ID 12170327-5mg. Molecular Weight 357.41. See USA prepack pricing. |  |
| E-64 | E-64 Inhibitor. Uses: Scientific use. Product Category: T6037. CAS No. 66701-25-5. |  |
| E-64 | E-64. CAS No: 66701-25-5 |  Sarchem Laboratories New Jersey NJ |
| E-64 | E-64. Group: Biochemicals. Alternative Names: Trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane; (L-3-trans-Carboxyoxiran-2-Carbonyl)-L-Leucyl-Admat. Grades: Highly Purified. CAS No. 66701-25-5. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C15H27N5O5. US Biological Life Sciences. |  Worldwide |
| E-64 | E-64 (Proteinase inhibitor E 64) is a potent irreversible inhibitor against general cysteine proteases with IC50 of 9 nM for papain. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Proteinase inhibitor E 64. CAS No. 66701-25-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15282. | |
| E6446 | E6446 is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1219925-73-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-12756. | |
| E6446 | E6446 is a novel synthetic antagonist for nucleic acid-sensing TLRs. Synonyms: E6446; E 6446; E-6446; 6-(3-(pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)benzo[d]oxazoleBMS-790052; EBP 883; BMS 790052; EBP883; BMS790052; EBP-883; BMS-790052. CAS No. 1219925-73-1. Molecular formula: C27H35N3O3. Mole weight: 449.59. | |
| E6446 | E6446 Inhibitor. Uses: Scientific use. Product Category: T4206. CAS No. 1219925-73-1. | |
| E6446 dihydrochloride | E6446 is a novel synthetic antagonist for nucleic acid-sensing TLRs. Synonyms: E-6446 dihydrochloride; E 6446 dihydrochloride; E6446 dihydrochloride; 6-(3-(pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)benzo[d]oxazole dihydrochloride. CAS No. 1345675-25-3. Molecular formula: C27H37Cl2N3O3. Mole weight: 522.51. | |
| E6446 dihydrochloride | E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1345675-25-3. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12756A. | |
| E 64c | E 64c is a derivative of naturally occurring epoxide inhibitor of cysteine proteases, a Calcium-activated neutral protease (CANP) inhibitor and a very weak irreversible cathepsin C inhibitor. E 64c exhibits entry-blocking effect for MERS-CoV. Uses: Scientific research. Category: Signaling pathways. CAS No. 76684-89-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100227. | |
| E 64c | E-64c is a cysteine protease inhibitor used for detecting autophagy in plants. Synonyms: Loxistatin acid. Grade: 98%. CAS No. 76684-89-4. Molecular formula: C15H26N2O5. Mole weight: 314.38. | |
| E 64d | E 64d. Group: Biochemicals. Grades: Purified. CAS No. 88321-09-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| E-64-d | E-64-d. Group: Biochemicals. Grades: Highly Purified. CAS No. 88321-09-9. Pack Sizes: 1mg, 2mg, 5mg. US Biological Life Sciences. | Worldwide |
| E64FC26 | E64FC26 is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6, respectively. E64FC26 shows anti-myeloma activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2285446-62-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122895. | |
| E64FC26 | E64FC26 is a highly potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6, respectively. E64FC26 has anti-myeloma activity. Synonyms: (E)-1-Nonylidene-3-(trifluoromethyl)-1H-indene-5,6-diol. Grade: 99%. CAS No. 2285446-62-8. Molecular formula: C19H23F3O2. Mole weight: 340.38. | |
| E67-2 | E67-2, a derivative of E67, is a selective and low-toxicity KIAA1718 Jumonji domain inhibitor with an IC50 of 3.4 μM. E67-2 selectively inhibits histone H3 lysine 9 (H3K9) Jumonji demethylase and histone H3 lysine 4 (H3K4) demethylase. Synonyms: 2,4-Quinazolinediamine, 7-[(5-aminopentyl)oxy]-N2-[3-(dimethylamino)propyl]-6-methoxy-N4,N4-dimethyl-; 7-((5-Aminopentyl)oxy)-N2-(3-(dimethylamino)propyl)-6-methoxy-N4,N4-dimethylquinazoline-2,4-diamine; N-[3-(Dimethylamino)propyl]-N',N'-dimethyl-6-methoxy-7-(5-aminopentyloxy)quinazoline-2,4-diamine. Grade: ≥95%. CAS No. 1364914-62-4. Molecular formula: C21H36N6O2. Mole weight: 404.55. | |
| E6 Berbamine | E6 Berbamine is a calmodulin inhibitor, which is also reported to inhibit P-glycoprotein activity in purified primary cultured rat brain microvessel endothelial cells at 10 μM. Calmodulin is the ubiquitous and multifunctional Ca2+-binding protein, which can mediate various regulatory effects of Ca2+. Synonyms: Berbamine p-nitrobenzoate; O-(4-Nitrobenzoyl)berbamine. Grade: ≥98%. CAS No. 114784-59-7. Molecular formula: C44H43N3O9. Mole weight: 757.8. | |
| e-6-Bromo-2-chloro-3-(2-nitro)vinylquinoline | e-6-Bromo-2-chloro-3-(2-nitro)vinylquinoline. Alternative Names: (E)-6-BROMO-2-CHLORO-3-(2-NITROVINYL)QUINOLINE, 1031929-34-6, CTK4A1841, AG-D-13608, E-6-Bromo-2-chloro-3-(2-nitro)vinylquinoline. CAS No. 1031929-34-6. Purity: 96%. Product ID: ACM1031929346. Molecular formula: C11H6BrClN2O2. Mole weight: 313.53. IUPAC Name: 6-bromo-2-chloro-3-(2-nitroethenyl)quinoline. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| E7016 | E7016 is an inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemo- and/or radiosensitizing activity. PARP inhibitor E7016 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks and promotes genomic instability and eventually leads to apoptosis. In addition, this agent may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. Synonyms: E 7016; E-7016; 10-((4-Hydroxypiperidin-1-yl)methyl)chromeno[4,3,2-de]phthalazin-3(2H)-one. Grade: ≥98%. CAS No. 902128-92-1. Molecular formula: C20H19N3O3. Mole weight: 349.39. | |
| E7016 | E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo through the inhibition of DNA repair. E7016 acts as a potential anticancer agent[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GPI 21016. CAS No. 902128-92-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13540. | |
| E7046 | E7046 is an orally bioavailable and specific type 4 prostaglandin E2 (PGE2) receptor EP antagonist (IC50= 13.5 nM) (Ki= 23.14 nM), with anti-tumor activities. Synonyms: E7046; E-7046; E 7046. 4-[(1S)-1-[[3-(difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]pyrazole-4-carbonyl]amino]ethyl]benzoic acid. CAS No. 1369489-71-3. Molecular formula: C22H18F5N3O4. Mole weight: 483.39. | |
| E-7050 (2S,3S)-2,3-dihydroxysuccinic acid | E-7050 (2S,3S)-2,3-dihydroxysuccinic acid is the salt form of Golvatinib, which is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity. Synonyms: 1,1-Cyclopropanedicarboxamide, N-[2-fluoro-4-[[2-[[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]amino]-4-pyridinyl]oxy]phenyl]-N'-(4-fluorophenyl)-, (2S,3S)-2,3-dihydroxybutanedioate (1:1); N-[2-Fluoro-4-[[2-[[[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl]amino]pyridin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (2S,3S)-tartrate; Golvatinib D-Tartaric acid; Golvatinib (2S,3S)-2,3-dihydroxysuccinic acid. Grade: 95%. CAS No. 1007601-97-9. Molecular formula: C33H37F2N7O4.C4H6O6. Mole weight: 783.78. | |
| E7080 (Lenvatinib) | Lenvatinib is a multi-target inhibitor, mostly for VEGFR2(KDR)/VEGFR3(Flt-4) with IC50 of 4 nM/5.2 nM, less potent against VEGFR1/Flt-1, ~10-fold more selective for VEGFR2/3 against FGFR1, PDGFRα/β in cell-free assays. Lenvatinib (E7080) also inhibits FGFR1-4, PDGFR, Kit (c-Kit), RET (c-RET), and shows potent antitumor activities. Phase 3. Group: Inhibitors. Alternative Names: E7080. CAS No. 417716-92-8. Pack Sizes: 2mg. Product ID: S1164. Formula: C21H19ClN4O4. Smiles: COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| E7090 | E7090 is an orally available, potent, and selective FGFR inhibitor with IC50s of 0.71 nM, 0.50 nM, 1.2 nM, and 120 nM for FGFR1/FGFR2/FGFR3/FGFR4, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1622204-21-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101466. | |
| E7090 succinate | E7090 succinate is a potent, selective and orally available inhibitor of FGFR1, FGFR2 and FGFR3 tyrosine kinase activities, with IC50s of 0.71, 0.50, 1.2 and 120 nM for FGFR1/2/3/4, respectively. Synonyms: 5-((2-(((4-(1-(2-Hydroxyethyl)piperidin-4-yl)phenyl)carbonyl)amino)pyridin-4-yl)oxy)-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide succinate (1:1.5); Butanedioic acid, compd. with 5-((2-((4-(1-(2-hydroxyethyl)-4-piperidinyl)benzoyl)amino)-4-pyridinyl)oxy)-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide (3:2). CAS No. 1879965-80-6. Molecular formula: C32H37N5O6.1.5(C4H6O4). Mole weight: 764.82. | |
| E-7386 | E-7386 is an orally active CBP/beta-catenin modulator. Uses: Scientific research. Category: Signaling pathways. CAS No. 1799824-08-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111386. | |
| E7449 | E7449 is an orally bioavailable, potent, small molecule inhibitor of PARP1 and PARP2, which enhances the efficacy of radiotherapy and chemotherapy and has potent single agent anticancer activity in BRCA-deficient tumors. Synonyms: E7449; E 7449; E-7449; 2X-121; 2X 121; 2X121. Grade: >98%. CAS No. 1140964-99-3. Molecular formula: C18H15N5O. Mole weight: 317.34. | |
| E7449 mesylate | E7449 mesylate is a dual inhibitor of PARP1/2 and tankyrase1/2. E7449 inhibits PARP enzymatic activity and additionally traps PARP1 onto damaged DNA. E7449 inhibited Wnt/β-catenin signaling in colon cancer cell lines, likely through TNKS inhibition. Synonyms: 2X-121; 8-(Isoindolin-2-ylmethyl)-2H-pyridazino[3,4,5-de]quinazolin-3(9H)-one methanesulfonate. Grade: 98%. CAS No. 1140965-47-4. Molecular formula: C18H15N5O.CH4O3S. Mole weight: 413.45. | |
| E-76 | E-76, a potent anticoagulant, is an inhibitor of coagulation factor VIIa. It acts by binding to an exosite on the VIIa protease domain and non-competitively inhibits the activation of factor X and amide hydrolytic activity. Synonyms: E-76; Acetyl-ALCDDPRVDRWYCQFVEG-amide; Ac-Ala-Leu-D-Cys-Asp-Asp-Pro-Arg-Val-Asp-Arg-Trp-Tyr-Cys-Gln-Phe-Val-Glu-Gly-NH2 (Disulfide bridge: Cys3-Cys13); N-acetyl-L-alanyl-L-leucyl-D-cysteinyl-L-alpha-aspartyl-L-alpha-aspartyl-L-prolyl-L-arginyl-L-valyl-L-alpha-aspartyl-L-arginyl-L-tryptophyl-L-tyrosyl-L-cysteinyl-L-glutaminyl-L-phenylalanyl-L-valyl-L-alpha-glutamyl-glycinamide (3->13)-disulfide. Grade: ≥95% by HPLC. CAS No. 1926163-13-4. Molecular formula: C97H139N27O29S2. Mole weight: 2211.47. | |
| E7766 diammonium salt | E7766 diammonium salt is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2242635-03-4. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg. Product ID: HY-111999A. | |
| E7766 diammonium salt | E7766 diammonium salt is one of macrocycle-bridged stimulator of interferon genes (STING) agonist with potent pan-genotypic activity. Grade: 98%. CAS No. 2242635-03-4. Molecular formula: C24H32F2N12O8P2S2. Mole weight: 780.66. | |
| E7766 disodium | E7766 disodium is one of macrocycle-bridged stimulator of interferon genes (STING) agonist with potent pan-genotypic activity. Synonyms: E7766 (disodium). CAS No. 2242636-28-6. Molecular formula: C24H26F2N10Na2O8P2S2. Mole weight: 792.58. | |
| E7820 | E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a molecular glue that induces the targeted degradation of splicing factor RBM39 by recruiting the E3 ubiquitin ligase CUL4-RBX1-DDB1-DCAF15 (CRL4DCAF15). E7820 is an angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC50 of 0.11 μg/ml. E7820 modulates α-1, α-2, α-3, and α-5 integrin mRNA expression. E7820 can be used for the study of acute myeloid leukemia (AML)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ER68203-00. CAS No. 289483-69-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14571. | |
| E 7820 | E7820 is an orally active unique angiogenesis inhibitor that inhibits the expression of integrin α2 subunit on endothelial cells and has antiangiogenic and antitumor activities. E7820 regulates the expression of α-1, α-2, α-3 and α-5 integrin mRNA, and inhibits rat aortic angiogenesis with an IC50 of 0.11 μg/mL. Synonyms: ER68203-00; N-(3-Cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzene-sulfonamide; NSC-719239; 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide; Benzenesulfonamide, 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)-. Grade: ≥95%. CAS No. 289483-69-8. Molecular formula: C17H12N4O2S. Mole weight: 336.37. | |
| E7974 | E7974 is an analog of the sponge-derived anti-microtubule tripeptide hemiasterlin with antimitotic and potential antineoplastic activities. Hemiasterlin analog E7974 binds to the Vinca domain on tubulin, resulting in inhibition of tubulin polymerization and microtubule assembly; depolymerization of exsiting microtubules; inhibition of mitosis; and inhibition of cellular proliferation. This agent may have more affinity for the beta-3 tubulin isotype. Synonyms: E 7974; E-7974; (S,E)-4-((S)-2-((R)-1-isopropylpiperidine-2-carboxamido)-N,3,3-trimethylbutanamido)-2,5-dimethylhex-2-enoic acid. CAS No. 610787-07-0. Molecular formula: C24H43N3O4. Mole weight: 437.62. | |
| e-7-Bromo-2-chloro-3-(2-nitro)vinylquinoline | e-7-Bromo-2-chloro-3-(2-nitro)vinylquinoline. Alternative Names: (E)-7-BROMO-2-CHLORO-3-(2-NITROVINYL)QUINOLINE, 1031929-36-8, CTK4A1842, AG-D-13609, E-7-Bromo-2-chloro-3-(2-nitro)vinylquinoline. CAS No. 1031929-36-8. Purity: 96%. Product ID: ACM1031929368. Molecular formula: C11H6BrClN2O2. Mole weight: 313.53. IUPAC Name: 7-bromo-2-chloro-3-(2-nitroethenyl)quinoline. Alfa Chemistry - ISO 9001:32057 Certified. | |
| e-8-Bromo-2-chloro-7-methoxy-3-(2-nitro)vinylquinoline | e-8-Bromo-2-chloro-7-methoxy-3-(2-nitro)vinylquinoline. Alternative Names: (E)-8-BROMO-2-CHLORO-7-METHOXY-3-(2-NITROVINYL)QUINOLINE, 1031929-46-0, CTK4A1851, AG-D-13618, E-8-Bromo-2-chloro-7-methoxy-3-(2-nitro)vinylquinoline. CAS No. 1031929-46-0. Purity: 96%. Product ID: ACM1031929460. Molecular formula: C12H8BrClN2O3. Mole weight: 343.56. IUPAC Name: 8-bromo-2-chloro-7-methoxy-3-(2-nitroethenyl)quinoline. Alfa Chemistry - ISO 9001:32057 Certified. | |
| E-982 | E-982 is a potent and selective inhibitor designed for the research of prostate cancer. This product exhibits high binding specificity to the androgen receptor, preventing its activation and subsequent tumor growth. Synonyms: E982; E 982; E-982. Grade: >98 %. CAS No. 858102-78-0. Molecular formula: C25H31NO6S. Mole weight: 473.58. | |
| EA2 | EA2 is a biological active peptide. (This is a peptide substrate for polypeptide N-acetylgalactosaminyltransferase (polypeptide GalNAc-T).). Uses: Scientific research. Category: Peptides. CAS No. 562082-63-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5473. | |
| EA4 | EA4 is a rPLA2 inhibitor, and it is a quinone derivative. rPLA2, a calcium-dependent cytosolic phospholipase A2 (cPLA2), was initially isolated and characterized from bovine and human red blood cells (RBCs). EA4 inhibits the ionophore-induced arachidonic acid release from human and bovine red blood cells (RBCs), indicating that rPLA2 is responsible for the Ca2+-dependent release of arachidonic acid from mammalian RBCs. Synonyms: 7-chloro-6-[4-(diethylamino)phenyl]-5,8-quinolinedione. Grade: ≥95%. CAS No. 389614-94-2. Molecular formula: C19H17ClN2O2. Mole weight: 340.8. | |
| EAAT2 activator 1 | EAAT2 activator 1 is a potent activator of the excitatory amino acid transporter 2 (EAAT2) and dose-dependently increases EAAT2 protein levels. EAAT2 is a major glutamate transporter whose function is to remove glutamate from synapses. Synonyms: 3-[(2-chloro-6-fluorophenyl)methylsulfanyl]-6-pyridin-2-ylpyridazine; Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)-; 3-[(2-Chloro-6-fluorobenzyl)sulfanyl]-6-(2-pyridinyl)pyridazine. Grade: ≥98%. CAS No. 892415-28-0. Molecular formula: C16H11ClFN3S. Mole weight: 331.80. | |
| EAAT2 activator 1 | EAAT2 activator 1 is the potent activator of excitatory amino acid transporter 2 (EAAT2). EAAT2 is the major glutamate transporter and functions to remove glutamate from synapses. EAAT2 activator 1 increases EAAT2 protein levels dose-dependently[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 892415-28-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139692. | |
| EA-CATH1 | EA-CATH1 has antibacterial activity. EA-CATH1 was found in Equus asinus. It appeared to be stable in serum and displayed no toxicity to human erythrocytes. Grade: >97% by HPLC. | |
| EACC | EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 864941-31-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129111. | |
| Eact | Eact is a selective and potent activator of TMEM16A, directly activates the TRPV1 channels in sensory nociceptors and produces itch, acute nociception and thermal hypersensitivity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 461000-66-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103368. | |
| Eact | Eact is a TMEM16A (ANO1) calcium-activated chloride channel (CaCC) activator (EC50 = 3 μM). Eact also stimulates transient receptor potential vanilloid 1 (TRPV1) channel activator (EC50 = 11.6 μM). Stimulates submucosal gland secretion in human bronchi. Synonyms: 3,4,5-Trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)benzamide. Grade: ≥99% by HPLC. CAS No. 461000-66-8. Molecular formula: C22H24N2O5S. Mole weight: 428.5. | |
| Eact | Eact. Group: Biochemicals. Grades: Purified. CAS No. 461000-66-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| EAD-1 | EAD-1, a chloroquinoline derivative, has been found to be an autophagy inhibitor that exhibit antiproliferative effct in lung and pancreatic cancer cells so that could be significant in anticancer studies. Synonyms: EAD1; EAD-1; EAD 1; N1-((1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)-N2-(2-((7-chloroquinolin-4-yl)amino)ethyl)-N2-methylethane-1,2-diamine. Grade: 98%. CAS No. 1644388-26-0. Molecular formula: C24H27Cl2N7. Mole weight: 484.43. | |
| EAD1 HCl | EAD1 HCl is an effective autophagy inhibitor with IC50 of 5.8 μM. It has antiproliferative activity in lung and pancreatic cancer cells. Grade: >95.0%. Molecular formula: C24H28Cl3N7. Mole weight: 520.89. | |
| EAD-1 TFA | EAD-1 is a potent and selective inhibitor of autophagy (IC50 = 5.8 μM in the BxPC3 cells) with antiproliferative activity in lung and pancreatic cancer cells. Synonyms: N-[[1-[(4-chlorophenyl)methyl]triazol-4-yl]methyl]-N'-[2-[(7-chloroquinolin-4-yl)amino]ethyl]-N'-methylethane-1,2-diamine; 2,2,2-trifluoroacetic acid. Grade: ≥98%. Molecular formula: C26H28Cl2F3N7O2. Mole weight: 598.45. | |
| EAFP1 | EAFP1 is produced by Eucommia ulmoides. It has antifungal activity against P.infestans, A.lycopersici, V.dahliae, G.zeae, A.nicotianae, F.moniliforme, F.oxysporum and C.gossypii. Synonyms: Antifungal peptide 1. | |
| EAFP2 | EAFP2 is produced by Eucommia ulmoides. The inhibition activity of EAFP2 can be effective on both chitin-containing and chitin-free fungi. Synonyms: Antifungal peptide 2. | |
| EAI001 | EAI001 is a potent, selective mutant epidermal growth factor receptor (EGFR) allosteric inhibitor with an IC50 value of 24 nM for EGFRL858R/T790M. EAI001 can be used for research of cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 892772-75-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100214. | |
| EAI045 | EAI045 is an allosteric, non-ATP competitive inhibitor of mutant EGFR. In vitro studies proved that EAI045 is active and selective for T790M- harboring EGFR mutants that are in a monomer state. In vivo the combination of EAI045 and cetuximab caused a marked tumor shrinkage in a mouse model carrying the EGFR mutant with L858R/T790M/C797S. Therefore, EAI045 is the first allosteric inhibitor that targets T790M and C797S EGFR mutants but it is effective only in combination with cetuximab. Synonyms: 2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide; 2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide; EAI045; EAI 045; EAI-045. CAS No. 1942114-09-1. Molecular formula: C19H14FN3O3S. Mole weight: 383.397. | |
| EAI045 | EAI045 is an allosteric and the fourth-generation inhibitor of mutant EGFR with IC50s of 1.9, 0.019, 0.19 and 0.002 μM for EGFR, EGFRL858R, EGFRT790M and EGFRL858R/T790M at 10 μM ATP, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1942114-09-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100213. | |
| EAK16-II | EAK16-II. CAS No. 157675-61-1. Molecular formula: C70H121N21O25. Mole weight: 1656.84. |  |
| EAK16-II | EAK16-II is a self-assembled peptide that can form a stable β-sheet structure and can be used as a carrier or matrix for cell culture. Synonyms: Ac-Ala-Glu-Ala-Glu-Ala-Lys-Ala-Lys-Ala-Glu-Ala-Glu-Ala-Lys-Ala-Lys-NH2; L-Lysinamide, N-acetyl-L-alanyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-L-alanyl-L-lysyl-L-alanyl-L-lysyl-L-alanyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-L-alanyl-L-lysyl-L-alanyl-. Grade: ≥95%. CAS No. 157675-61-1. Molecular formula: C70H121N21O25. Mole weight: 1656.84. | |
| Easy Transfer: Monolayer Graphene on Polymer Film | Easy Transfer: Monolayer Graphene on Polymer Film - Processed in Clean Room Class 1000 We applied our long experience in growing and transferring high quality graphene films to let you experiment with any novel substrate. | |
| EAVRLFIEWLKNGGPSSGAPPPS | EAVRLFIEWLKNGGPSSGAPPPS is a polypeptide from patent CN 106029087 A. The incretin receptor ligands are derived from multiple skin toxicity Shan exosomes -3 skin of SDGTFTSDLSKQM Di EAVRLFIEWLKNGGPSSGAPPPS. Synonyms: Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser. Grade: >98%. Molecular formula: C110H169N29O32. Mole weight: 2409.75. | |
| EB1002 | EB1002 is a highly selective, long-acting NK2R agonist. EB1002 exerts central appetite suppression, increases peripheral energy expenditure and enhances insulin sensitivity, which effectively reduces body weight, improves glucose and lipid metabolism, with favorable safety profiles. EB1002 can be used for research on diseases such as obesity and type 2 diabetes[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2770688-48-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10746. | |
| EB 1089 | EB 1089. Group: Biochemicals. Grades: Purified. CAS No. 134404-52-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| EB-3D | EB-3D is a potent and selective inhibitor of choline kinase α (ChoKα). EB-3D exerts effects on ChoKα expression, AMPK activation, apoptosis, endoplasmic reticulum stress and lipid metabolism. Synonyms: 1,1'-(((Ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide. CAS No. 1839150-63-8. Molecular formula: C30H36Br2N4O2. Mole weight: 644.44. | |
| EB-3D | EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC50 of 1 μM for ChoKα1. EB-3D exerts effects on ChoKα expression, AMPK activation, apoptosis, endoplasmic reticulum stress and lipid metabolism. EB-3D exhibits a potent antiproliferative activity in a panel of T-leukemia cell lines. Anti-cancer activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1839150-63-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-115463. | |
| EB-42486 | EB-42486 is a potent and highly selective inhibitor of G2019S-LRRK2 with an IC50 of <0.2 nM. Synonyms: Tetrazolo[1,5-a]pyrimidine-6-carboxamide, 4,7-dihydro-4,5,7,7-tetramethyl-N-(3-phenyl-1H-indazol-5-yl)-. CAS No. 2390475-81-5. Molecular formula: C22H22N8O. Mole weight: 414.46. | |
| EB 47 | EB 47. Group: Biochemicals. Grades: Purified. CAS No. 1190332-25-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
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