A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Navacaprant (BTRX-335140) is a selective and orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8 nM, 110 nM, and 6500 nM, respectively.Navacaprant endows with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rats. Navacaprant distributes well into the CNS and can be used for the research of neuropathy[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BTRX-335140; CYM-53093. CAS No. 2244614-14-8. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-124754.
Navarixin
Navarixin (SCH 527123) is a potent, allosteric and orally active antagonist of both CXCR1 and CXCR2, with Kd values of 41 nM for cynomolgus CXCR1 and 0.20 nM, 0.20 nM, 0.08 nM for mouse, rat and cynomolgus monkey CXCR2, respectivelly[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SCH 527123; MK-7123. CAS No. 473727-83-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10198.
Navepdekinra
Navepdekinra (DC-806) is an orally active, potent interleukin-17A (IL-17A) inhibitor (IC50 = 10.81 nM). Navepdekinra disrupts the IL-17A protein-receptor interaction, suppressing the downstream pro-inflammatory signaling pathway. Navepdekinra inhibits arthritis in a collage-induced arthritis (CIA) rat model. Navepdekinra can be used for psoriasis, psoriatic arthritis, and ankylosing spondylitis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DC-806; LY4100504; S-011806. CAS No. 2467732-66-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153780.
Navitoclax
Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABT-263. CAS No. 923564-51-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10087.
Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2. Group: Inhibitors. CAS No. 923564-51-6. Pack Sizes: 1g. Product ID: S1001. Formula: C47H55ClF3N5O6S3. Smiles: CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C. Storage Conditions: 2 years -80 in solvent.
United States; Europe
Navitoclax-piperazine
Navitoclax-piperazine (ABT-263-piperazine) is a Navitoclax (HY-10087) analog and BCL-XL inhibitor. Navitoclax-piperazine is the ligand for target protein of PROTAC DT2216 (HY-130604). Navitodax-pperaie and E3 ubiquitin ligase VHL ligand can be used to synthesize PROTAC DT2216 (HY-130604)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABT-263-piperazine. CAS No. 2143096-93-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-44432.
Navitoclax (Standard)
Navitoclax (Standard) is the analytical standard of Navitoclax. This product is intended for research and analytical applications. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABT-263 (Standard). CAS No. 923564-51-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10087R.
Navivumab
Navivumab (CT-P23) is a monoclonal antibody targeting the hemagglutinin (HA) of influenza A virus. Navivumab binds to the HA2 stem fusion domain and the low-variability HA2 region of influenza viruses. Navivumab neutralizes influenza A viruses of subtypes H1, H2, H5, and H9. Navivumab is applicable to research related to influenza and influenza A[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CT-P23. CAS No. 1443004-16-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99750.
Navlimetostat
Navlimetostat is a potent, orally active, selective PRMT5-MTA complex inhibitor, with IC50 of 3.6 and 20.5 nM for PRMT5-MTA and PRMT5. Navlimetostat binds to the PRMT5-MTA complex, with KD value of 0.14 pM. Navlimetostat shows antineoplastic activity in vitro and in vivo, and can be used for cancer study[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MRTX-1719; BMS-986504. CAS No. 2630904-45-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139611.
Navoximod
Navoximod (GDC-0919; NLG-?919) is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GDC-0919; NLG-919. CAS No. 1402837-78-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18770B.
Navtemadlin
Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMG 232; KRT-232. CAS No. 1352066-68-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12296.
Naxitamab
Naxitamab (Hu3F8) is a humanized monoclonal antibody targeting the disialoganglioside GD2. Naxitamab can be used in research of neuroblastoma, osteosarcoma and other GD2-positive cancers[1]. Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: Naxitamab-gqgk; Humanized 3F8; Hu3F8. CAS No. 1879925-92-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99206.
NAZ2329
NAZ2329, the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), allosterically and preferentially inhibits PTPRZ (IC50=7.5 μM for hPTPRZ1) and PTPRG (IC50=4.8 μM for hPTPRG) over other PTPs. NAZ2329 binds to the active D1 domain and more potently inhibits PTPRZ-D1 fragment (IC50 of 1.1 μM) than the whole intracellular (D1?+?D2) fragment (IC50 of 7.5 μM). NAZ2329 can effectively inhibit tumor growth of the glioblastoma cells and suppress stem cell-like properties[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2809469-05-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103693.
Nazartinib
Nazartinib (EGF816) is a covalent mutant-selective EGFR inhibitor, with Ki and Kinact of 31 nM and 0.222 min-1 on EGFR(L858R/790M) mutant, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EGF816. CAS No. 1508250-71-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-12872.
N-a-Z-D-Arginine
N-a-Z-D-Arginine. Group: Biochemicals. Grades: Highly Purified. CAS No. 6382-93-0. Pack Sizes: 5g, 10g, 25g, 50g, 100g. US Biological Life Sciences.
Worldwide
Na-Z-D-arginine 99+% (HPLC)
Na-Z-D-arginine 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 5g, 25g, 100g. US Biological Life Sciences.
Worldwide
Na-Z-D-arginine hydrochloride 98+% (HPLC)
Na-Z-D-arginine hydrochloride 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences.
Worldwide
Na-Z-D-asparagine 98+% (HPLC)
Na-Z-D-asparagine 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 5g, 25g, 100g. US Biological Life Sciences.
Worldwide
Na-Z-D-histidine 99+%
Na-Z-D-histidine 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences.
Worldwide
Na-Z-DL-asparagine 98+%
Na-Z-DL-asparagine 98+%. Group: Biochemicals. Grades: Reagent Grade. CAS No. 29880-22-6. Pack Sizes: 5g, 25g, 100g, 250g. US Biological Life Sciences.
Worldwide
Na-Z-DL-histidine 99+% (HPLC)
Na-Z-DL-histidine 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences.
Worldwide
Na-Z-DL-tryptophan 99+%
Na-Z-DL-tryptophan 99+%. Group: Biochemicals. Grades: Reagent Grade. CAS No. 13058-16-7. Pack Sizes: 5g, 25g. US Biological Life Sciences.
Worldwide
Na-Z-D-lysine 99+%
Na-Z-D-lysine 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences.
Worldwide
Na-Z-D-lysine benzyl ester benzenesulfonate salt 99+%
Na-Z-D-lysine benzyl ester benzenesulfonate salt 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg, 1g. US Biological Life Sciences.
Worldwide
Na-Z-D-ornithine 99+%
Na-Z-D-ornithine 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences.
Worldwide
Na-Z-D-tryptophan 98+% (HPLC)
Na-Z-D-tryptophan 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 5g, 25g, 100g, 250g. US Biological Life Sciences.
N-(azide-PEG4)-3,3-Dimethyl-3H-indole-N'-(m-PEG3)-Benzothiazole Cy5. Uses: For analytical and research use. CAS No. 2107273-88-9. Molecular formula: C39H54ClN5O7S. Mole weight: 772.40. Purity: ≥95%. Catalog: APB2107273889.
N-(Azido-PEG2)-N-Biotin-PEG3-acid
N-(Azido-PEG2)-N-Biotin-PEG3-acid is aclick chemistry biotinylation reagent. The azide group enables Click Chemistry. The terminal carboxylic acid can react with primary amino groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Grade: 98%. CAS No. 2112731-59-4. Molecular formula: C25H44N6O9S. Mole weight: 604.7.
N-(Azido-PEG2)-N-Boc-PEG3-NHS ester
N-(Azido-PEG2)-N-Boc-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG2)-N-Boc-PEG3-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2093153-85-4. Pack Sizes: 100 mg; 250 mg. Product ID: HY-140559.
N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester
N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2100306-76-9. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-140581.
N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester
N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester is a polyethylene glycol (PEG)-based PROTAC linker. N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester can be used in the synthesis of a series of PROTACs. Synonyms: methyl 1-{5-[(3aR,4R,6aS)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethyl)pentanamido}-3,6,9,12-tetraoxapentadecan-15-oate; methyl 1-azido-12-(5-((3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoyl)-3,6,9,15,18,21,24-heptaoxa-12-azaheptacosan-27-oate. Grade: 98%. CAS No. 2100306-76-9. Molecular formula: C30H54N6O11S. Mole weight: 706.85.