A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
rvastatin Impurity 43. Uses: For analytical and research use. Alternative Names: sodium 4-(1b-(4-fluorophenyl)-7-hydroxy-7-isopropyl-1a-phenyl-7a-(phenylcarbamoyl)hexahydro-1aH-oxireno[2',3':3,4]pyrrolo[2,1-b][1,3]oxazin-3-yl)-3-hydroxybutanoate 4-(6a-(4-fluorophenyl)-7-hydroxy-1a-isopropyl-7-phenyl-7a-(phenylcarbamoyl)hexahydro-1aH-o. Molecular formula: C33H34FN2NaO7. Mole weight: 612.62. Catalog: APB02549.
RVD-Hpα
RVD-Hpα is a neuropeptide that acts as a selective CB1 receptor agonist. It has been demonstrated to increase the phosphorylation of ERK1/2 levels or release of intracellular Ca2+. CAS No. 1193362-76-3. Molecular formula: C65H105N19O17. Mole weight: 1424.66.
RVD-Hpα acetate
RVD-Hpα acetate is a neuropeptide that acts as a selective CB1 receptor agonist. It has been demonstrated to increase the phosphorylation of ERK1/2 levels or release of intracellular Ca2+. It is also a high-affinity CB2 positive allosteric modulator (Ki = 50 nM). Synonyms: H-Arg-Val-Asp-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH.CH3CO2H; L-arginyl-L-valyl-L-alpha-aspartyl-L-prolyl-L-valyl-L-asparagyl-L-phenylalanyl-L-lysyl-L-leucyl-L-leucyl-L-seryl-L-histidine. Grade: ≥95%. Molecular formula: C67H109N19O19. Mole weight: 1484.71.
R-Venlafaxine
R-Venlafaxine. Group: Biochemicals. Alternative Names: 1-[ (1R) -2- (Dimethylamino) -1- (4-methoxyphenyl) ethyl]cyclohexanol; (+)-Venlafaxine. Grades: Highly Purified. CAS No. 93413-46-8. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C17H27NO2. US Biological Life Sciences.
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R-Venlafaxine-di-p-toluoyl-D-tartrate Salt
A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant. Group: Biochemicals. Grades: Highly Purified. CAS No. 272788-00-8. Pack Sizes: 5mg. US Biological Life Sciences.
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RVG
RVG (RVG29) is a blood-brain barrier-permeable peptide derived from rabies virus glycoprotein, which binds to the α-7 subunit of neuronal nicotinic acetylcholine receptor (AchR). RVG efficiently delivers drugs to nerve cells and antigen-presenting cells in a targeted manner, and enhances the efficiency of antigen presentation and drug delivery[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RVG29; RDP; Rabies Virus Glycoprotein-29. CAS No. 115136-25-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5623.
RVG-9R
RVG-9R, a chimeric rabies virus glycoprotein fragment, binds and transduces siRNA in vitro into neuronal cells, resulting in highly efficient gene silencing. Repeated administration of RVG-9R-bound siRNA did not induce inflammatory cytokines or anti-peptide antibodies. Synonyms: Rabies Virus Glycoprotein (194-221) Nonaarginine Chimer; H-Tyr-Thr-Ile-Trp-Met-Pro-Glu-Asn-Pro-Arg-Pro-Gly-Thr-Pro-Cys-Asp-Ile-Phe-Thr-Asn-Ser-Arg-Gly-Lys-Arg-Ala-Ser-Asn-Gly-Gly-Gly-Gly-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH. Grade: ≥95%. CAS No. 1678417-57-6. Molecular formula: C201H334N82O55S2. Mole weight: 4843.51.
RVG-Cys
RVG-Cys (RVG29-Cys) is a peptide derived from rabies virus glycoprotein (RVG29) with Cys attached to facilitate subsequent conjugation. RVG-Cys enhances the specific targeted delivery of proteins in brain tissue and neurons[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RVG29-Cys; RDP-Cys; Rabies Virus Glycoprotein-29-Cys. CAS No. 1186105-01-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5623A.
RWJ 21757
RWJ 21757. Group: Biochemicals. Grades: Purified. CAS No. 121288-39-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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RWJ 50271
RWJ 50271. Group: Biochemicals. Grades: Purified. CAS No. 162112-37-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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RWJ 50271
RWJ 50271 is an selective and orally active inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction with an IC50 of 5.0 μM (HL60 cells). RWJ 50271 inhibits LFA-1/ICAM-1-mediated cell adhesion[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 162112-37-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110086.
RWJ 52353
RWJ 52353. Group: Biochemicals. Grades: Purified. CAS No. 245744-10-9. Pack Sizes: 10mg. US Biological Life Sciences.
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RWJ 56110
RWJ 56110. Group: Biochemicals. Grades: Purified. CAS No. 252889-88-6. Pack Sizes: 1mg. US Biological Life Sciences.
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RWJ-56110 dihydrochloride
RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), quite selective relative to U46619 (HY-108566). RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2387505-58-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108556A.
RWJ 67657
RWJ 67657 is an orally active inhibitor of the MAP kinases p38alpha and p38beta (IC50s = 1 and 11 uM, respectively, in vitro) that is inactive against p38gamma and p38delta, as well as several other kinases. It blocks the release of TNF-alpha and IL-1beta from peripheral blood mononuclear cells stimulated with LPS (IC50s = 3 and 11 nM, respectively) and inhibits TNF-alpha production in LPS-treated mice and rats. RWJ 67657 potently blocks the proliferation of CD4+ peripheral blood T cells induced by CD28 stimulation alone (IC50 = 0.5-4nM). It is commonly used to study the roles of p38alpha and p38beta in cellular and whole animal systems. Group: Biochemicals. Alternative Names: 4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol; 4-(4-Fluorophenyl)-2-(4-hydroxy-1-butynyl)-1-(3-phenylpropyl)-5-(4-Pyridyl)imidazole; JNJ 3026582; RWJ 67657. Grades: Highly Purified. CAS No. 215303-72-3. Pack Sizes: 1mg, 5mg, 10mg, 50mg. US Biological Life Sciences.
Worldwide
RWJ-67657
RWJ-67657 (JNJ 3026582) is an orally active and selective p38α and p38β MAPK inhibitor with IC50s of 1 and 11 μM, respectively. RWJ-67657 displays no activity at p38γ and p38δ, and exhibits cardio protective effect. Anti-inflammatory and anti-tumor activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JNJ 3026582. CAS No. 215303-72-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15505.
RX-3117
RX-3117 (TV-1360) is a potent and orally active anticancer and antimetaboliteagent. RX-3117 inhibits DNA methyltransferase 1 (DNMT1). RX-3117 shows antiproliferative and anti-tumour activity. RX-3117 induces cell cycle arrest at S phase and apoptosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TV-1360; Fluorocyclopentenylcytosine. CAS No. 865838-26-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-15228.
RX 821002 hydrochloride
RX 821002 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 109544-45-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
A cell-permeable 2-acetamido-N-phenylbenzamide that selectively activates human, but not mouse, LGR7/RXFP1-mediated cAMP induction (EC50 = 200nM in THP1) via allosteric interaction with the ECL3 region without competing against ECL2-mediated relaxin binding or affecting AVPR1B- or LGR8/RXFP2-mediated cAMP induction. Although shown to be ~150-fold and 500-fold less potent than relaxin (RLX), respectively, in VEGF mRNA induction and cellular impedance assays, pharmacokinetic studies reveal superior in vivo stability to RLX and in vivo bioavailability in mice via oral (Cmax/Tmax = 604nM/plasma/1h and 1026ng/g heart/1.5h; 30mg/kg) or intraperitoneal (Cmax/Tmax = 9.29uM/plasma/1h and 28.6uMol/kg heart/1h; 30mg/kg) administration with good aqueous solubility (7uM in PBS). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
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RXFP3/4 agonist 2
RXFP3/4 agonist 2 is a potent, nonpeptide dual RXFP3/4 agonist (EC50=3.1 and 2.7 nM). RXFP3/4 agonist 2 also potently promotes interactions between RXFP3 and β-arrestin-2 with EC50 values in the range of 10-22 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2752378-78-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145278.
RXP03
RXP03 is a MMPs inhibitor with the Ki of 20 nM, 2.5 nM, 10 nM, 5nM and 105 nM for MMP-2, MMP-8, MMP-9, MMP-11, MMP-14, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 284667-65-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-162038.
RXP470.1
RXP470.1 (RXP-470) is a potent, selective MMP-12 inhibitor with a Ki of 0.2 nM against human MMP-12. RXP470.1 is 2 to 4 orders of magnitude less potent against other MMPs. RXP470.1 significantly reduces atherosclerotic plaque cross-sectional area in mouse. RXP470.1 results in less complex plaques with increased smooth muscle cell:macrophage ratio, less macrophage apoptosis, increased cap thickness, smaller necrotic cores, and decreased incidence of calcification[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RXP-470. CAS No. 891198-31-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-135517.
RY785
RY785 is a potent and selective voltage-gated potassium (KV2) channel inhibitor with an IC50 of 0.05 μM for KV2.2. RY785 has analgesic activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1393748-80-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114608.
RY796
RY796 is a potent and selective voltage-gated potassium (KV2) channel inhibitor with IC50s of 0.25 μM and 0.09 μM for KV2.1 and KV2.2. RY796 has analgesic activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1393441-53-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120033.
Ryanodine
Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca2+ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa. Uses: Scientific research. Category: Signaling pathways. CAS No. 15662-33-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-103306.
Ryanodine
Ryanodine. Group: Biochemicals. Grades: Purified. CAS No. 15662-33-6. Pack Sizes: 1mg. US Biological Life Sciences.
A cell-permeable, orally active benzothiazepine that effectively blocks leaky intracellular calcium release by preventing the dissociation/depletion of calstabin from the ryanodine receptor (RyR) complex due to receptor modifications, such as oxidation, S-nitrosylation, hyperphosphorylation, or mutation (complete blockage of 1 mM tetracaine-induced leakage in murine RyR2 S2808D+/+ myocytes at 1uM). Shown to prevent stress-induced cognitive dysfunction by stabilizing RyR2-calstabin-2 (FKBP12.6) interaction in brain (75mg/kg/day; p.o.) and maintain exercise capacity by stabilizing RyR1-calstabin-1 (FKBP12) interaction in skeletal muscle (2. 5ug/0. 25uL/h/animal; s.c) in mice, as well as restore normal cardiac function (20mg/kg/day; s.c) in mice with R2474S or S2808D RyR2 mutation in vivo.Primary Target:RyR2. Group: Biochemicals. Alternative Names: 7-methoxy-4-methyl-2, 3, 4, 5-tetrahydrobenzo[f][1, 4]thiazepine, Ryanodine Receptor Stabilizer; Rycal S107. Grades: Highly Purified. CAS No. 927871-76-9. Pack Sizes: 10mg. Molecular Formula: C??H??NOS, Molecular Weight: 209.3. US Biological Life Sciences.
Worldwide
Ryuvidine
Ryuvidine. Group: Biochemicals. Grades: Purified. CAS No. 265312-55-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Ryuvidine
Ryuvidine is a potent inhibitor of SET domain-containing protein 8(SETD8) with an IC50 of 0.5 μM and suppresses monomethylation of H4K20. Ryuvidine also inhibits CDK4 with an IC50 of 6.0 μM. Ryuvidine also inhibits KDM5A and blocks DNA synthesis. Ryuvidine has anticancer activity against tumors such as breast cancer. Ryuvidine improves arthritis[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 265312-55-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100624.