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| Product | Description | |
|---|---|---|
| TfR-T12 | TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide. CAS No. 344618-30-0. Molecular formula: C71H99N19O15S. Mole weight: 1490.73. |  |
| TfR Targeting Peptide | The 12-mer peptide sequence is a transferrin receptor (TfR) targeting peptide. It binds to TfR and is internalized via endocytosis into TfR-expressing cells. TfR targeting peptide is a potential carrier for transportation of small molecules across the blood-brain barrier to the brain, or into malignant tissues. Synonyms: H-Thr-His-Arg-Pro-Pro-Met-Trp-Ser-Pro-Val-Trp-Pro-OH; L-threonyl-L-histidyl-L-arginyl-L-prolyl-L-prolyl-L-methionyl-L-tryptophyl-L-seryl-L-prolyl-L-valyl-L-tryptophyl-L-proline; TfR-T12. Grade: ≥95%. Molecular formula: C71H99N19O15S. Mole weight: 1490.75. | |
| TG003 | TG003 is a potent inhibitor of Clk1/Sty; inhibits Clk1 and Clk4 with IC50 values of 20 and 15 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 719277-26-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15338. |  |
| TG 003 | TG 003. Group: Biochemicals. Grades: Purified. CAS No. 719277-26-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| TG100-115 | TG100-115 is a selective PI3Kγ/PI3Kδ inhibitor with IC50s of 83 and 235 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 677297-51-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10111. | |
| TG 100572 Hydrochloride | TG 100572 Hydrochloride is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 867331-64-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10185. | |
| TG 100713 | TG 100713. Group: Biochemicals. Grades: Purified. CAS No. 925705-73-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TG 100801 | TG 100801 is a proagent that generates TG 100572 by de-esterification in development to treat age-related macular degeneration. TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 867331-82-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10186. | |
| TG101209 | TG101209. Group: Biochemicals. Alternative Names: N- (1, 1-Dimethylethyl) -3- [ [5-methyl-2- [ [4- (4-methyl-1-piperazinyl) phenyl] amino] -4-pyrimidinyl] amino] benzenesulfonamide. Grades: Highly Purified. CAS No. 936091-14-4. Pack Sizes: 2.5mg. Molecular Formula: C26H35N7O2S, Molecular Weight: 509.67. US Biological Life Sciences. | Worldwide |
| TG101348 (SAR302503) | TG101348 is a potent, and selective inhibitor of JAK2 (IC50 = 3 nM). It has a 35- and 334-fold selectivity over JAK3 and JAK1, respectively. Group: Biochemicals. Alternative Names: N-tert-butyl-3- (5-methyl-2- (4- (2- (pyrrolidin-1-yl) ethoxy) phenylamino) pyrimidin-4-ylamino) benzenesulfonamide. Grades: Highly Purified. CAS No. 936091-26-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| TG2-179-1 | TG2-179-1 is a potent BAP1 inhibitor. TG2-179-1 inhibits the domain-containing deubiquitinase (DUB) activity of BAP1 by covalently binding to its active site. TG2-179-1 exerts cytotoxic activity, leading to defective replication and increased apoptosis. TG2-179-1 has the potential for colon cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1135023-19-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-158774. | |
| TG 4-155 | TG 4-155. Group: Biochemicals. Grades: Purified. CAS No. 1164462-05-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TG4-155 | TG4-155 is a potent, brain-permeant and selective EP2 receptor antagonist with a Ki of 9.9 nM[1][2]. TG4-155 shows low nanomolar antagonist activity against only EP2 and DP1[1]. TG4-155 has an EP2 Schild KB of 2.4 nM and displays 550-4750-fold selectivity for EP2 over EP1, EP3, EP4 and IP, but only 14-fold selectivity against the DP1 receptor[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1164462-05-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-18971. | |
| TG53 | TG53 is a novel inhibitor of tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction. Group: Biochemicals. Grades: Highly Purified. CAS No. 946369-04-6. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C21H22ClN5O2, Molecular Weight: 411.88. US Biological Life Sciences. | Worldwide |
| TGF α (1-50) (rat) | TGF α (1-50) (rat) was originally identified as an agent that can reversibly confer a transformed phenotype on normal non-tumor cells, such as normal rat renal fibroblasts. This activity requires the presence of transforming growth factor-β (TGF-β), which enhances the effects of TGF-α through a separate receptor. TGF-α is synthesized by monocytes, keratinocytes and a variety of tissues and tumors. (approx. ED50 = 0.2 ng/mL). Synonyms: H-Val-Val-Ser-His-Phe-Asn-Lys-Cys-Pro-Asp-Ser-His-Thr-Gln-Tyr-Cys-Phe-His-Gly-Thr-Cys-Arg-Phe-Leu-Val-Gln-Glu-Glu-Lys-Pro-Ala-Cys-Val-Cys-His-Ser-Gly-Tyr-Val-Gly-Val-Arg-Cys-Glu-His-Ala-Asp-Leu-Leu-Ala-OH (Disulfide bridge: Cys8-Cys21, Cys16-Cys32, Cys34-Cys43); Transforming Growth Factor-α (1-50) from rat. CAS No. 89899-53-6. Molecular formula: C244H361N71O71S6. Mole weight: 5617.38. | |
| TGF β1 Antibody [P22B16] | TGF beta 1,Transforming Growth Factor-beta1. Group: Antibodies. Alternative Names: Transforming Growth Factor-β1, TGFB1, TGFB. CAS No. Pack Sizes: 20uL. Product ID: F1624. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. |  United States; Europe |
| TGFβ-IN-5 | TGFβ-IN-5 is a type I transforming growth factor-β receptor (TGF-β R1) kinase inhibitor with an IC50 value of 0.0485 μM. TGFβ-IN-5 reverses the effect of TGF-β-mediated cell activation on the expression of fibrosis-related genes. TGFβ-IN-5 can be used in the research of fibroproliferative diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 259870-32-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128437. | |
| TGF-beta receptor type-2 (131-139) | TGF-beta receptor type-2 (131-139) is a truncated fragment of TGF-beta receptor type-2. TGF-beta receptor type-2 is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. Synonyms: Transforming Growth Factor Beta Receptor 2 (131-139); TGF-Beta Type II Receptor (131-139). | |
| TGFβRI-IN-3 | TGFβRI-IN-3 inhibits TGFβR1 at an IC50 of 0.79 nM with 2000-fold selectivity against MAP4K4. TGFβRI-IN-3 represents a highly selective TGFβR1 inhibitor that has potential applications in immuno-oncology[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2763602-67-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132290. | |
| TGF-beta/Smad Compound Library | A unique collection of 180 TGF-beta/Smad signaling targeted compounds for high throughput and high content screening; - Bioactivity and safety confirmed by pre-clinical research and clinical trials; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L4100. Categories: TGF-beta/Smad Compounds Libraries. |  |
| TGFBR1-IN-2 | TGFBR1-IN-2 (Compound AQA) is a TGFBR1 inhibitor and an antibacterial agent. TGFBR1-IN-2 is a substrate for cytochrome P450s. TGFBR1-IN-2 contains the pyridyl-6-methyl moiety necessary for Mycobacterium tuberculosis inhibition and has potent inhibitory activity against non-replicating and persistent Mycobacterium tuberculosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 733806-89-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164793. | |
| TGN 020 | TGN 020. Group: Biochemicals. Grades: Purified. CAS No. 51987-99-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TGN-020 | TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM[1][2]. TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[3].TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats[4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 51987-99-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W008574. | |
| TGN-020 sodium | TGN-020 sodium is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM[1][2]. TGN-020 sodium is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[3]. TGN-020 sodium alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats[4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1313731-99-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-W008574A. | |
| TGN-073 | TGN-073 is an orally active, blood-brain barrier-permeable aquaporin 4 (AQP4) modulator. TGN-073 increases the uptake and distribution of brain MRI tracers in the brain parenchyma and reduces the levels of insoluble amyloid β-40 and β-42. TGN-073 can be used in research related to Alzheimer's disease, dementia, traumatic brain injury and pain[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 877459-36-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-W176557. | |
| TGR5 Receptor Agonist | TGR5 Receptor Agonist (CCDC), a potent Takeda G protein-coupled receptor 5 (TGR5; GPCR19) agonist, shows improved potency in the U2-OS cells and melanophore cells with pEC50s of 6.8 and 7.5, respectively. TGR5 Receptor Agonist can induce peripheral and central hypersensitivity to bladder distension in mice, and increase intracellular Ca2+ concentration. TGR5 Receptor Agonist can also reduces food intake and improves insulin responsiveness, in diet-induced obese mice. TGR5 Receptor Agonist can be used to research diabetes, bladder hypersensitivity and anti-obesity[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CCDC. CAS No. 1197300-24-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14229. | |
| TGR5 Receptor Agonist (3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide) | Cell-permeable, small molecule agonist of TGR5 G-protein coupled receptor. This agonist has shown to increase glucagon like peptide-1 (GLP-1) secretion from primary intestinal cells. Group: Biochemicals. Alternative Names: 3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| TGR5 Receptor Agonist, Cpd23g ( (4-cyclopropyl-3, 4-dihydroquinoxalin-1 (2H) -yl) (4- (2, 5-dimethylphenoxy) pyridin-3-yl) methanone, Bile Acid Receptor GPBAR-1 Agonist, Bile Acid Receptor Agonist, G Protein-coupled Bile Acid Receptor 1 Agonist) | A cell-permeable, orally available, phenoxypyrimidine carboxamide derivative that acts as a highly potent and selective agonist of Protein coupled receptor TGR5 (EC50 = 720 pM and 6.2nM for human and mouse TGR5, respectively). Does not exhibit any significant affinity towards other related targets such as GPR40, GPR119, and GPR120. Shown to increase glucagon-like peptide-1 (GLP-1) secretion in a dose-dependent manner and significantly reduce blood glucose levels in db/db mice following a single oral dose (50mg/kg). Exhibits desirable pharmacokinetic properties in rodent models (t½ = 1.5h, Cmax = 56ng/ml; and AUC = 147ng.h/ml following an oral dose of 5mg/kg). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| TGX-115 | TGX-115 is a p110β/p110δ-selective, PI3-K inhibitor. TGX-115 blocks p110β-mediated Akt phosphorylation induced by lysophosphatidic acid (LPA) in L6 myotubes, reduces insulin-stimulated PI(3,4)P2 and PIP3 levels in 3T3-L1 adipocytes. TGX-115 can be used for the study of diabetes mellitus[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 351071-62-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-124535. | |
| TGX-115, PI3K Inhibitor (8-(2-Methylphenoxy)-2-(4-morphonilyl)-4(1H)-quinolinone) | Cell-permeable. A potent and selective inhibitor of PI 3-K isoforms p110b/p110e (IC?? p110b=0.13uM, p110e=0.63uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 351071-62-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| TGX-221 | TGX-221 is a potent, selective, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, used for cancer treatment. Uses: Scientific research. Category: Signaling pathways. CAS No. 663619-89-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10114. | |
| TGX-221, PI3K Inhibitor (±)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)-pyrido[1,2-a]-pyrimidin-4-one) | Cell-permeable. A potent, selective and ATP-competitive inhibitor of PI 3-kinase b (IC?? = 5nM for p110b). Inhibits other PI3K isoforms at higher concentrations (IC?? = 0.1uM for p110e, 5uM for p110a, and 3.5uM for p110g). Group: Biochemicals. Grades: Highly Purified. CAS No. 663619-89-4. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| TH1020 | TH1020 is a potent and selective toll-like receptor 5 (TLR5)/flagellin complex antagonist with an IC50 of 0.85 μM. TH1020 inhbits flagellin-induced TLR5 signaling. TH1020 is inactive against TLR2, TLR3, TLR4, TLR7 and TLR8[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1841460-82-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116961. | |
| TH10785 | TH10785 is a DNA glycosylase 1 (OGG1) activator, TH10785 can interact with the phenylalanine-319 and glycine-42 amino acids of OGG1 and increase the enzyme activity, generates β, δ-lyase enzymatic function. TH10785 can control the catalytic activity mediated by a nitrogen base within its molecular structure. TH10785 can be used for the research of various diseases and aging connected with DNA oxidative lesions[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1002801-51-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147313. | |
| TH1834 | TH1834 is a specific Tip60 (KAT5) histone acetyltransferase (HAT) inhibitor. TH1834 induces apoptosis and increases DNA damage in breast cancer. TH1834 does not affect the activity of related histone acetyltransferase MOF. Anticancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2108830-08-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123604. | |
| TH1834 dihydrochloride | TH1834 dihydrochloride is a specific Tip60 (KAT5) histone acetyltransferase inhibitor. TH1834 dihydrochloride induces apoptosis and increases DNA damage in breast cancer. TH1834 dihydrochloride does not affect the activity of related histone acetyltransferase MOF. Anticancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2108830-09-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123604A. | |
| TH287 | TH287 is a potent and selective inhibitor of MTH1, with an IC50 of 0.8 nM. TH287 is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 could act as a chemotherapeutic agent for cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1609960-30-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16965. | |
| TH588 | TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM). Uses: Scientific research. Category: Signaling pathways. CAS No. 1609960-31-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12814. | |
| TH9619 | TH9619 is a potent inhibitor of dehydrogenase and cyclohydrolase activities in both MTHFD1 and MTHFD2 with a IC50 value of 47 nM, and selectively kills cancer cells. TH9619 induces apoptosis by blocking the S phase. TH9619 has antitumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2379556-22-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-155950. | |
| Thailanstatin A | Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding linker-less ADC[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1426953-21-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-129589. | |
| Thailanstatin A | Thailanstatin A. CAS No. 1426953-21-0. Product ID: PI1426953210. Molecular formula: C28H41NO9. Mole weight: 535.6. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| Thailanstatin B | Thailanstatin B is a pre-mRNA splicing inhibitor. Thailanstatin B is used as a cytotoxin for ADCs. Synonyms: EX-A5053. CAS No. 1426953-23-2. Molecular formula: C28H42ClNO9. Mole weight: 572.1. | |
| Thailanstatin C | Thailanstatin C is an antiproliferative agent and pre-mRNA splicing inhibitor (IC50 = 6.84 μM) from Burkholderia thailandensis MSMB43. Synonyms: (1S,5R)-1,5-Anhydro-1-(carboxymethyl)-3-C-(chloromethyl)-2-deoxy-5-{(1E,3E)-5-[(2S,3S,5R,6R)-5-{[(2Z,4S)-4-(isobutyryloxy)-2-pentenoyl]amino}-3,6-dimethyltetrahydro-2H-pyran-2-yl]-3-methyl-1,3-pentadien-1-yl}-D-erythro-pentitol; D-arabino-Heptonic acid, 3,7-anhydro-5-C-(chloromethyl)-2,4-dideoxy-7-C-[(1E,3E)-3-methyl-5-[(2S,3S,5R,6R)-tetrahydro-3,6-dimethyl-5-[[(2Z,4S)-4-(2-methyl-1-oxopropoxy)-1-oxo-2-penten-1-yl]amino]-2H-pyran-2-yl]-1,3-pentadien-1-yl]-, (7R)-. Grade: ≥95%. CAS No. 1426953-24-3. Molecular formula: C30H46ClNO9. Mole weight: 600.14. | |
| Thailanstatin D | Thailanstatin D inhibits AR-V7 gene splicing by interfering the interaction between U2AF65 and SAP155 and preventing them from binding to polypyrimidine tract located between the branch point and the 3' splice site. Thailanstatin D exhibits a potent tumor inhibitory effect on human CRPC xenografts leading to cell apoptosis. Synonyms: Spliceostatin C. CAS No. 1609105-89-6. Molecular formula: C28H41NO8. Mole weight: 519.63. | |
| thalianol synthase | This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. Group: Enzymes. Synonyms: (S)-2,3-epoxysqualene mutase (cyclizing, thalianol-forming). Enzyme Commission Number: EC 5.4.99.31. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5572; thalianol synthase; EC 5.4.99.31; (S)-2,3-epoxysqualene mutase (cyclizing, thalianol-forming). Cat No: EXWM-5572. |  |
| Thalidomide | Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ?250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate. Uses: Scientific research. Category: Signaling pathways. CAS No. 50-35-1. Pack Sizes: 10 mM * 1 mL in DMSO; 200 mg; 500 mg. Product ID: HY-14658. | |
| Thalidomide (2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione) | Inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. Group: Biochemicals. Alternative Names: 2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione. Grades: Highly Purified. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| Thalidomide 4-chloro | Thalidomide 4-chloro is a chlorinated E3 ligase activator. Thalidomide 4-chloro may be used for further derivitization by substitution of chlorine. Uses: Scientific research. Category: Signaling pathways. CAS No. 244057-36-1. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-W460141. | |
| Thalidomide 4-fluoride | Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cereblon ligand 4; E3 ligase Ligand 4. CAS No. 835616-60-9. Pack Sizes: 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-41547. | |
| Thalidomide-4-O-C5-NH2 hydrochloride | Thalidomide-4-O-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2419145-66-5. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-138848A. | |
| Thalidomide-4-O-C6-NH2 hydrochloride | Thalidomide-4-O-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12F36V and BET[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2245697-88-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-135250B. | |
| Thalidomide 5-fluoride | Thalidomide 5-fluoride is a thalidomide-based Cereblon ligand used to recruit Cereblon protein. Thalidomide 5-fluoride can be linked to target protein ligands (e.g. IRAK4) through a linker to form PROTAC molecules (e.g. PROTAC IRAK4 degrader-1). PROTAC IRAK4 degrader-1 caused <20%,>20-50%, and >50% IRAK4 protein degradation in OCI-LY-10 cells at concentrations of 0.01, 0.1, and 1 μM, respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 835616-61-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W087383. | |
| Thalidomide-5-O-C4-NH2 hydrochloride | Thalidomide-5-O-C4-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate, consisting of a cereblon ligand based on Thalidomide (HY-14658) and a linker[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2694727-93-8. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-149561. | |
| Thalidomide-5-OH | Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 64567-60-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g; 25 g. Product ID: HY-23095. | |
| Thalidomide-5-propargyne-NH2 hydrochloride | Thalidomide-5-propargyne-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-propargyne-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2490402-62-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139546. | |
| Thalidomide-CH2NH2 hydrochloride | Thalidomide-CH2NH2 hydrochloride is a Thalidomide analogue featuring a primary amine, which is a versatile group which may participate in many reactions. Uses: Scientific research. Category: Signaling pathways. CAS No. 444287-40-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-44249. | |
| Thalidomide-[d4] | Thalidomide-[d4] is the labelled analogue of Thalidomide, which inhibits an E3 ubiquitin ligase and is used as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. Synonyms: Thalidomide D4; 2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione-d4. Grade: 95% by HPLC; 95% atom D. CAS No. 1219177-18-0. Molecular formula: C13H6D4N2O4. Mole weight: 262.25. | |
| Thalidomide-d4 (2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione-d4) | Labelled Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. Group: Biochemicals. Alternative Names: 2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione-d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Thalidomide Impurity 1 | Thalidomide Impurity 1. Uses: For analytical and research use. CAS No. 26581-81-7. Molecular formula: C13H12N2O3. Mole weight: 244.25. Catalog: APB26581817. |  |
| Thalidomide Impurity 2 | Thalidomide Impurity 2. Uses: For analytical and research use. Molecular formula: C11H10BrNO3. Mole weight: 284.11. Catalog: APB12318. | |
| Thalidomide-NH-amido-C4-NH2 | Thalidomide-NH-amido-C4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2093388-67-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134984. | |
| Thalidomide-NH-C6-NH2 hydrochloride | Thalidomide-NH-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2375194-37-7. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg; 1 g. Product ID: HY-129704B. | |
| Thalidomide-NH-PEG1-NH2 hydrochloride | Thalidomide-NH-PEG1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2154342-56-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131867. | |
| Thalidomide-NH-PEG3-propionic acid | Thalidomide-NH-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2138440-82-9. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 250 mg; 1 g. Product ID: HY-136166. | |
| Thalidomide-O-amido-C4-N3 | Thalidomide-O-amido-C4-N3 is a synthetic E3 ligase ligand-linker conjugate, consisting of a cereblon ligand based on Thalidomide (HY-14658) and a linker[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cereblon Ligand-Linker Conjugates 4; E3 ligase Ligand-Linker Conjugates 18. CAS No. 2098488-36-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103615. | |
| Thalidomide-O-amido-C4-NH2 hydrochloride | Thalidomide-O-amido-C4-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2245697-86-1. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 100 mg. Product ID: HY-107438A. | |
| Thalidomide-O-amido-C8-NH2 TFA | Thalidomide-O-amido-C8-NH2 TFA (Cereblon Ligand -Linker Conjugates 2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cereblon Ligand -Linker Conjugates 2 TFA; E3 Ligase Ligand-Linker Conjugates 20 TFA. CAS No. 1950635-16-1. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-103614. | |
| Thalidomide-O-amido-PEG3-C2-NH2 TFA | Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cereblon Ligand-Linker Conjugates 3 TFA; E3 ligase Ligand-Linker Conjugates 14 TFA. CAS No. 1957236-21-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103611. | |
| Thalidomide-O-C3-azide | Thalidomide-O-C3-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C3-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C3-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2758432-00-5. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg. Product ID: HY-157510. | |
| Thalidomide-O-C6-azide | Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide (HY-14658) based cereblon ligand and a linker used in PROTAC technology[1]. Thalidomide-O-C6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2411389-65-4. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148556. | |
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