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| Product | Description | |
|---|---|---|
| VX-561 | VX-561, also known as d9-ivacaftor, is an agonist of cystic fibrosis transmembrane conductance regulator (CFTR) channel developed for the treatment of cystic fibrosis. VX-561 is in a phase II clinical trial for safety and efficacy evaluation. Uses: Potential treatment of cystic fibrosis. Synonyms: CTP-656; N-(2-(tert-butyl)-5-hydroxy-4-(2-(methyl-d3)propan-2-yl-1,1,1,3,3,3-d6)phenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide; d9-ivacaftor. CAS No. 1413431-07-8. Molecular formula: C24H19D9N2O3. Mole weight: 401.55. |  |
| VX-680 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| VX 702 | VX 702. Group: Biochemicals. Grades: Purified. CAS No. 479543-46-9. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| VX-702 | VX-702 is a highly selective inhibitor of p38? MAPK, 14-fold higher potency against the p38? versus p38?[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 745833-23-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10401. |  |
| VX-702 | VX-702. Group: Biochemicals. Alternative Names: 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide. Grades: Highly Purified. CAS No. 745833-23-2. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C19H12F4N4O2. US Biological Life Sciences. | Worldwide |
| VX 745 | VX 745 is a potent and selective inhibitor of p38α mitogen-activated protein (MAP) kinase. VX 745 is a potential anti-inflammatory agents. Studies suggest that VX 745 may be useful in the treatment of Werner syndrome. Group: Biochemicals. Alternative Names: 5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one. Grades: Highly Purified. CAS No. 209410-46-8. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| VX-745 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| VX-765 | VX-765. Group: Biochemicals. Alternative Names: N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide; Belnacasan. Grades: Highly Purified. CAS No. 273404-37-8. Pack Sizes: 5mg. Molecular Formula: C24H33ClN4O6, Molecular Weight: 509. US Biological Life Sciences. | Worldwide |
| VX-809 (Lumacaftor) | VX-809 (Lumacaftor). Group: Biochemicals. Alternative Names: 3- [6- [ [ [1- (2, 2-Difluoro-1, 3-benzodioxol-5-yl) cyclopropyl] carbonyl] amino] -3-methyl-2-pyridinyl] benzoic Acid; Lumacaftor; VRT 826809. Grades: Highly Purified. CAS No. 936727-05-8. Pack Sizes: 50mg, 100mg, 250mg. Molecular Formula: C??H??F?N?O?, Molecular Weight: 452.51. US Biological Life Sciences. | Worldwide |
| VX-809 (Lumacaftor) | Lumacaftor (VX-809, VRT 826809) acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation,EC50 of 0.1 μM in fisher rat thyroid cells. Phase 3. Group: Inhibitors. Alternative Names: VRT 826809. CAS No. 936727-05-8. Pack Sizes: 5mg. Product ID: S1565. Formula: C24H18F2N2O5. Smiles: CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| VX-984 | VX-984 is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 is a de novo deuterium[1][2][3]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: M9831. CAS No. 1476074-39-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19939S. | |
| VY-3-135 | VY-3-135 is a potent, orally active, and stable ACSS2 inhibitor with an IC50 value of 44 nM. VY-3-135 is specific to ACSS2 among the AcCoA synthetase family of enzymes. VY-3-135 does not inhibit ACSS1 or ACSS3 enzymatic activity. VY-3-135 can be used for the research of breast cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1824637-41-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145953. | |
| VY-3-135 | VY-3-135 is a potent ACSS2 inhibitor. VY-3-135 acts as a transition-state mimetic to block ACSS2 activity in vitro and in vivo. Pharmacologic inhibition of ACSS2 as a single agent impaired breast tumor growth. The aqueous solubility of VY-3-135 was 21.7 μM. The aqueous solubility of VY-3-135 was 21.7 μM. VY-3-135 is a potent low nanomolar inhibitor of ACSS2 in cancer cells in vitro. VY-3-135 potently inhibits ACSS2 dependent fatty acid metabolism but has no effect on gene expression in tumors. Uses: Designed for use in research and industrial production. Additional or Alternative Names: VY-3-135; VY3-135; VY 3-135; VY-3135; VY3135; VY 3135. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1824637-41-3. Molecular formula: C26H27N3O3. Mole weight: 429.52. Purity: >98%. IUPACName: (R)-1-Ethyl-2-(hydroxydiphenylmethyl)-N-(2-hydroxypropyl)-1H-benzo[d]imidazole-6-carboxamide. Canonical SMILES: O=C(C1=CC=C2C(N(CC)C(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)=N2)=C1)NC[C@H](O)C. Product ID: ACM1824637413. Alfa Chemistry ISO 9001:2015 Certified. |  |
| VZ185 | VZ185 is a potent, fast, and selective von Hippel-Lindau based dual degrader probe of BRD9 and BRD7 with DC50s of 4.5 and 1.8 nM, respectively. VZ185 is cytotoxic in EOL-1 and A-402 cells, with EC50s of 3 nM and 40 nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2306193-61-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114322. | |
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