A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Z-S-benzyl-L-cysteine 4-nitrophenyl ester 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g, 100g. US Biological Life Sciences.
Worldwide
Z-S-benzyl-L-cysteine 99+% (HPLC)
Z-S-benzyl-L-cysteine 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 5g, 25g, 100g, 250g. US Biological Life Sciences.
Worldwide
Z-Ser-OL
N-Cbz-2-Amino-1,3-propanediol (CAS# 71811-26-2) is a useful research chemical. Synonyms: Cbz-Ser-OL; Benzyl (1,3-dihydroxypropan-2-yl)carbamate; Carbamic acid, [2-hydroxy-1-(hydroxymethyl)ethyl]-, phenylmethyl ester; N-Cbz-2-Amino-1,3-propanediol. CAS No. 71811-26-2. Molecular formula: C11H15NO4. Mole weight: 225.24.
Z-Ser-Thr-OMe
Z-Ser-Thr-OMe. Synonyms: (2S,3R)-methyl 2-((S)-2-(benzyloxycarbonylamino)-3-hydroxypropanamido)-3-hydroxybutanoate; Z Ser Thr OMe. Grade: ≥ 98% (TLC). CAS No. 7412-61-5. Molecular formula: C16H22N2O7. Mole weight: 354.36.
Z-Ser-Thr-OMe
Z-Ser-Thr-OMe. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 10g. US Biological Life Sciences.
Worldwide
ZSET1446
ZSET1446 is a novel cognitive enhancer that significantly improves learning deficits in various types of Alzheimer disease (AD) models. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ST-101. CAS No. 887603-94-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11013.
One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 20-fold overdigestion with enzyme 90% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 1000U; 5000U. ATGCA↑T T↓ACGTA. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer B, BSA. Storage: -20°C. Form: Liquid. Source: Zoogloea species 2. Pack: 10 mM Tis-HCl (pH 7.5); 200 mM KCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1192RE.
ZSTK474
ZSTK474 is an ATP-competitive pan-class I PI3K inhibitor with IC50s of 16 nM, 44 nM, 4.6 nM and 49 nM for P&Lota;3Κα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 475110-96-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-50847.
ZT-12-037-01
ZT-12-037-01 is a STK19-targeted inhibitor, has a high-affinity interaction with STK19 protein and inhibits oncogenic NRAS-driven melanocyte malignant transformation. ZT-12-037-01 is an ATP-competitive inhibitor, inhibiting phosphorylation of NRAS (major isoform of Ras family) with an IC50 of 24 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2328073-61-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122866.
ZT-1a
ZT-1a is a potent, non-ATP-competitive and selective SPAK inhibitor. ZT-1a inhibits SPAK activity with IC50s of 44.3, 35.0, 46.7 μM at ATP concentrations of 0.01, 0.1 and 1 mM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 212135-62-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-136532.
Z-Tyr-Lys-Arg-pNA is a chromogenic substrate. Z-Tyr-Lys-Arg-pNA can be used to detect the activity of subtilisin-type and yapsin-like proteases[1]. Uses: Scientific research. Category: Peptides. CAS No. 108318-36-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4517.
The presence of halogen substituents on the fluorescent group improves the membrane permeability of YVAD-derived Caspase-1 substrate Z-YVAD-AFC. Synonyms: L-a-Asparagine, N-[(phenylmethoxy)carbonyl]-L-tyrosyl-L-valyl-L-alanyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-; N-[(Benzyloxy)carbonyl]-L-tyrosyl-L-valyl-L-alanyl-N-[2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl]-L-α-asparagine; Caspase-1 Substrate (AFC); Z-YVAD-AFC. Grade: ≥90%. CAS No. 201608-13-1. Molecular formula: C39H40F3N5O11. Mole weight: 811.76.
Z-Tyr-Val-Ala-DL-Asp-fluoromethylketone
Z-YVAD-FMK is a cell-permeable potent irreversible inhibitor of caspase-1 and -4. Synonyms: Z-YVAD-FMK. CAS No. 1926163-56-5. Molecular formula: C31H37FN4O10. Mole weight: 616.64.
Zubotamig (Gen1047) is an CD3E/VTCN1-targeting Ig(G1 -κ_G1 -λ2) type chimeric human antibody. The recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001). Zubotamig induces T-cell mediated cytotoxicity of B7H4-positive tumor cells, triggers T-cell activation, and induces cytokine release from T cells in the presence of B7H4-expressing tumor cells. Zubotamig demonstrates antitumor activity in mouse patient-derived xenograft (PDX) models. Zubotamig can be used for the research of solid cancers (including breast, ovarian and lung cancer)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Gen1047. CAS No. 2640279-10-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990953.
Zuclopenthixol
The cis(Z)-form of Clopenthixol. Thioxanthene neuroleptic. Antipsychotic. Group: Biochemicals. Alternative Names: 4-[(3Z)-3-(2-Chloro-9H-thioxanthen-9-ylidene)propyl]-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Zuclopenthixol (-)-10-Camphorsulfonic Acid Salt
The labeled cis(Z)-form of Clopenthixol. Thioxanthene neuroleptic. Antipsychotic. Group: Biochemicals. Alternative Names: 4-[(3Z)-3-(2-Chloro-9H-thioxanthen-9-ylidene)propyl]-d Salt. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Zuclopenthixol-d4 (-)-10-Camphorsulfonic Acid Salt
The labeled cis(Z)-form of Clopenthixol. Thioxanthene neuroleptic. Antipsychotic. Group: Biochemicals. Alternative Names: 4-[(3Z)-3-(2-Chloro-9H-thioxanthen-9-ylidene)propyl]-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Zuclopenthixol-d4 Succinate Salt
The labeled cis(Z)-form of Clopenthixol. Thioxanthene neuroleptic. Antipsychotic. Group: Biochemicals. Alternative Names: 4-[(3Z)-3-(2-Chloro-9H-thioxanthen-9-ylidene)propyl]-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Zuclopenthixol Decanoate EP Impurity A
Zuclopenthixol Decanoate EP Impurity A. Uses: For analytical and research use. CAS No. 55501-05-8. Molecular formula: C32H43ClN2O2S. Mole weight: 555.2. Catalog: APB55501058.
Zuclopenthixol Decanoate EP Impurity B
Zuclopenthixol Decanoate EP Impurity B. Uses: For analytical and research use. CAS No. 86-39-5. Molecular formula: C13H7ClOS. Mole weight: 246.7. Catalog: APB86395.
Zunsemetinib
Zunsemetinib (CDD-450) is an orally active and selective p38α mitogen-activated protein kinase-activated protein kinase 2 (MK2) pathway inhibitor. Zunsemetinib can be used for the research of immuno-inflammatory diseases[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ATI-450; CDD-450. CAS No. 1640282-42-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-139553.
Zurletrectinib
Zurletrectinib is a brain-penetrant, orally active TRK inhibitor (TRKA IC50 = 0.81 nM; TRKB IC50 = 0.145 nM; TRKC IC50 = 0.184 nM). Zurletrectinib exhibits stronger activity as a consequence of its augmented binding affinity for TRK kinases. Zurletrectinib exhibits higher activity against most TRK inhibitor resistance mutations (13 out of 18 mutations). Zurletrectinib can be used for the study of glioma[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ICP-723. CAS No. 2403703-30-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148811.
Z-VAD
Z-VAD is an irreversible, broad-spectrum pan-caspase inhibitor that can inhibit a variety of caspases including caspase-3, -6, -7, -8, -9, etc. (with a weaker inhibitory effect on caspase-2). Z-VAD can block apoptosis signaling pathways, induce autophagy and necrosis in tumor cells, and has anti-angiogenic activity. Z-VAD can enhance the sensitivity of breast cancer and lung cancer cells to radiotherapy in vitro and in vivo, and prolong the growth delay of tumor xenograft models. Z-VAD is well tolerated and is mainly used in research related to cancer radiosensitization and cell death pathway regulation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 162852-62-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-164388.
Z-VAD-FMK is a broad spectrum pan-caspase inhibitor that inhibits the intracellular activation of caspase-like proteases. Synonyms: Z-VAD (OMe)-FMK; Caspase Inhibitor I. Grade: >98.0%. CAS No. 187389-52-2. Molecular formula: C22H30FN3O7. Mole weight: 467.49.
Z-VAD-FMK
Z-VAD-FMK (Z-VAD(OMe)-FMK) is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells. Group: Inhibitors. Alternative Names: Z-VAD(OMe)-FMK. CAS No. 187389-52-2. Pack Sizes: 5mg. Product ID: S7023. Formula: C22H30FN3O7. Smiles: CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1. Storage Conditions: 2 years -80 in solvent.
United States; Europe
Z-VAD-FMK
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Z-VAD(OH)-FMK. CAS No. 161401-82-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16658B.
Z-VAD-FMK (Cell permeable)
Cell-permeable, non-selective broad-spectrum caspase inhibitor. Binds irreversibly to the catalytic site of caspase proteases. The peptide is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Potent inhibitor of caspase-1 activation in NLRP3-induced cells. Used in apoptosis and inflammasome studies. Group: Biochemicals. Grades: Highly Purified. CAS No. 187389-52-2, 634911-81-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C22H30FN3O7. US Biological Life Sciences.
Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor[1]. Z-VAD(OMe)-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Z-Val-Ala-Asp(OMe)-FMK. CAS No. 187389-52-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16658.
Z-Val-Ala-Asn-AMC
Z-Val-Ala-Asn-AMC is a substrate for the determination of cysteine endopeptidase required for antigen processing and has been used as a fluorescent substrate for porcine asparaginyl endopeptidase (AEP, legumain). Synonyms: Cbz-Val-Ala-Asn-AMC; L-Aspartamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-alanyl-N1-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-; Z-VAN-AMC; Butanediimidic acid, 2-[[(2S)-1-hydroxy-2-[[(2S)-1-hydroxy-2-[[hydroxy(phenylmethoxy)methylene]amino]-3-methylbutylidene]amino]propylidene]amino]-N1-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-, (2S)-; benzyl ((S)-1-(((S)-1-(((S)-4-amino-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1,4-dioxobutan-2-yl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate. Grade: ≥95%. CAS No. 245036-58-2. Molecular formula: C30H35N5O8. Mole weight: 593.64.
Z-VAD-FMK is an irreversible tripeptide inhibitor of all caspases, useful in studies involving enzymes. Synonyms: Z-vad-FMK; N-[(Phenylmethoxy)carbonyl]-L-valyl-N-[3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide; benzyloxycarbonyl-Val-Ala-DL-Asp(O-methyl)-fluoromethyl ketone. CAS No. 634911-81-2. Molecular formula: C22H30FN3O7. Mole weight: 467.49.
Z-Val-Ala-OH
Z-Val-Ala-OH is a useful reagent in the preparation and biological evaluation of peptide amide conjugates of nucleosides as prodrugs that are converted to parent drugs by action of DPPIV/CD26. Synthesis and evaluation of diacylhydrazines as inhibitors of the interleukin-1β converting enzyme. Synonyms: Z-L-valyl-L-alanine; (S)-2-((S)-2-(((Benzyloxy)Carbonyl)Amino)-3-Methylbutanamido)Propanoic Acid; Z Val Ala OH. Grade: ≥ 98% (HPLC). CAS No. 24787-89-1. Molecular formula: C16H22N2O5. Mole weight: 322.36.
Z-Val-Ala-OH
Z-Val-Ala-OH. Group: Biochemicals. Alternative Names: Z-L-valyl-L-alanine. Grades: Highly Purified. CAS No. 24787-89-1. Pack Sizes: 2g, 5g, 10g, 25g. US Biological Life Sciences.
Worldwide
Z-VAL-ALA-OH
Z-VAL-ALA-OH is a protected dipeptide composed of L-valine and L-alanine. It is a pre-formed sequence used to simplify the synthesis of larger peptides. Applications: It is commonly used in the synthesis of peptide-based enzyme substrates and inhibitors, specifically targeting proteases. Category: Intermediates. Synonyms: Z-L-VALYL-L-ALANINE. CAS No. 24787-89-1. Product ID: INT24787891. Molecular formula: C16H22N2O5. Mole weight: 322.36. InChIKey: KDQLNJPBTLIYNW-AAEUAGOBSA-N. Appearance: White to off-white solid.
Z-Val-Ala-OH 98+% (HPLC)
Z-Val-Ala-OH 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences.
Worldwide
Z-Val-Arg-Pro-DL-Arg-fluoromethylketone
Z-Val-Arg-Pro-DL-Arg-fluoromethylketone, a cell-permeable and irreversible inhibitor of para-caspase MALT1, is based on the sequence of a published optimal tetrapeptide substrate for the A. thaliana metacaspase AtMC9. Synonyms: MALT1 Inhibitor; Z-VRPR-FMK; L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-(2-fluoroacetyl)butyl]-; Cbz-Val-Arg-Pro-DL-Arg-CH2F; N-[(Phenylmethoxy)carbonyl]-L-valyl-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-(2-fluoroacetyl)butyl]-L-prolinamide. Grade: ≥95%. CAS No. 1926163-57-6. Molecular formula: C31H49FN10O6. Mole weight: 676.79.
Z-Val-Asp(OMe)-Val-Ala-DL-Asp(OMe)-fluoromethylketone is a cell-permeable fluoromethylketone that specifically inhibits caspase-2 and, to a lesser extent, caspase-3 and caspase-7. Synonyms: Z-VD(OMe)VAD(OMe)-FMK; Z-VDVA-(DL-Asp)-FMK; Methyl (5S,8S,11S,14S)-17-(fluoroacetyl)-5,11-diisopropyl-8-(2-methoxy-2-oxoethyl)-14-methyl-3,6,9,12,15-pentaoxo-1-phenyl-2-oxa-4,7,10,13,16-pentaazanonadecan-19-oate. Grade: ≥90%. CAS No. 1926163-61-2. Molecular formula: C32H46FN5O11. Mole weight: 695.73.