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| Product | Description | |
|---|---|---|
| 8-Octadecyloxypyrene-1,3,6-trisulfonic acid trisodium salt | 8-Octadecyloxypyrene-1,3,6-trisulfonic acid trisodium salt. Group: Biochemicals. Grades: Highly Purified. CAS No. 111024-84-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C34H43O10S3·3Na. US Biological Life Sciences. |  Worldwide |
| 8-Octanoyloxypyrene-1,3,6-trisulfonic acid trisodium salt | 8-Octanoyloxypyrene-1,3,6-trisulfonic acid trisodium salt. CAS No. 115787-84-3. Product ID: ACM115787843. Molecular formula: C24H21Na3O11S3. Mole weight: 650.58. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| 8-O-Demethyl-7-O-methyl-3,9-dihydropunctatin | 8-O-Demethyl-7-O-methyl-3,9-dihydropunctatin is isolated from the herbs of Scilla scilloides. Synonyms: 5,8-Dihydroxy-3-(4-hydroxybenzyl)-7-methoxy-4-chromanone. Grade: 97%. CAS No. 93078-83-2. Molecular formula: C17H16O6. Mole weight: 316.3. |  |
| 8-O-Demethyl Ivabradine HCl | 8-O-Demethyl Ivabradine HCl is a pharmaceutical compound meticulously employed in the research of diverse cardiovascular diseases. Its distinctive mechanism of action is acting as a selective inhibitor of the hyperpolarization-activated cyclic nucleotide-gated channel is allows for the proficient modulation of heart rate and commendable enhancement of cardiac function. Synonyms: 3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-8-hydroxy-7-methoxy-2H-3-benzazepin-2-one HCl. Grade: > 95%. Molecular formula: C26H35ClN2O5. Mole weight: 491.03. | |
| 8-OH-2'-O-Me-cAMP | 8-OH-2'-O-Me-cAMP is an activator of the exchange protein activated by cAMP (Epac) or cAMP-GEF, which does not activate protein kinase A. It can be used in patch clamp applications. Synonyms: 8- Hydroxy- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 98% by HPLC. Molecular formula: C11H13N5O7P · Na. Mole weight: 381.2. | |
| 8-OH-Ado | 8-OH-Ado is used for analysis of oxidative/radioactive stress RNA hydrolysates. Synonyms: 8- Hydroxyadenosine. Grade: ≥ 97% by HPLC. CAS No. 29861-67-8. Molecular formula: C10H13N6O6. Mole weight: 283.3. | |
| 8-OH-cAMP | 8-OH-cAMP is a polar analogue of cAMP used for the study of extracellular cAMP receptors. When applied by patch clamp techniques, 8-OH-cAMP remains trapped inside the cell. It exhibits a resistant effect of mammalian cyclic nucleotide-dependent phosphodiesterases. Synonyms: 8- Hydroxyadenosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 98% by HPLC. CAS No. 31356-95-3. Molecular formula: C10H11N5O7P · Na. Mole weight: 367.2. | |
| 8-OH-cGMP | 8-OH-cGMP is a cyclic guanosine monophosphate (cGMP) analog used in biomedical research. It acts as a second messenger in signal transduction pathways. 8-OH-cGMP is mainly utilized for studying the role of cGMP in various cellular processes, including smooth muscle relaxation, cell proliferation, and neurotransmission. It is also commonly used to investigate the pathophysiology and potential therapeutic targets in diseases related to altered cGMP signaling, such as hypertension, cardiovascular disorders, and neurodegenerative diseases. Synonyms: 8- Hydroxyguanosine- 3', 5'- cyclic monophosphate. CAS No. 21082-28-0. Molecular formula: C10H11N5O8P · Na. Mole weight: 383.2. | |
| 8-OH-DPAT | 8-OH-DPAT is a potent, brain-penetrant and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5). Uses: Scientific research. Category: Signaling pathways. Alternative Names: 8-Hydroxy-DPAT. CAS No. 78950-78-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112061. |  |
| 8-OH-DPAT | 8-OH-DPAT (8-Hydroxy-DPAT) is an agonist that has selectivity for 5-HT1A receptor (pIC50 = 8.19). It was subsequently found to be a serotonin reuptake inhibitor and a 5-HT7 receptor agonist as well. Studies showed that it exhibited antidepressant, anxiolytic and other properties. Uses: Serotonin receptor agonists. Synonyms: 8-HYDROXY-2-(DI-n-PROPYLAMINO)TETRALIN; 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol; CHEMBL56; Ro-31-8220 in solution; 8-Hydroxy-DPAT. Grade: 99.03 %. CAS No. 78950-78-4. Molecular formula: C16H25NO. Mole weight: 247.38. | |
| 8-OH-DPAT hydrobromide | 8-OH-DPAT (8-Hydroxy-DPAT) hydrobromide is a potent, brain-penetrant and selective 5-HT1A agonist with a pIC50 of 8.19. 8-OH-DPAT hydrobromide has selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 8-Hydroxy-DPAT hydrobromide. CAS No. 76135-31-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15688. | |
| 8-O-Methylthiomelin | 8-O-Methylthiomelin is a xanthone compound. CAS No. 113734-85-3. Molecular formula: C16H12Cl2O5. Mole weight: 355.17. | |
| 8-OOH-Ivermectin H2B1a | 8-OOH-Ivermectin H2B1a is an impurity of Ivermectin, an antiparasitic drug that is active against a wide variety of nematode and arthropod parasites and is used to treat scabies and lice in humans. Synonyms: 8-OOH-Ivermectin B1a; Ivermectin 8alpha-Hydroperoxide. CAS No. 2962875-15-4. Molecular formula: C48H74O16. Mole weight: 907.10. | |
| 8-Oxabicyclo[3.2.1]octa-2,6-diene-2-carboxylicacid,(1S)-(9CI) | 8-Oxabicyclo[3.2.1]octa-2,6-diene-2-carboxylicacid,(1S)-(9CI). CAS No. 183800-06-8. Product ID: ACM183800068. Molecular formula: C8H8O3. Alfa Chemistry - ISO 9001:32057 Certified. | |
| 8-Oxo-2-deoxyadenosine | 8-Oxo-2-deoxyadenosine. Group: Biochemicals. Alternative Names: 2'-Deoxy-7,8-dihydro-8-oxo-adenosine; 2'-Deoxy-7,8-dihydroadenosin-8-one; 7,8-Dihydro-8-oxodeoxyadenosine; 8-Oxo-2'-deoxyadenosine; 8-Oxo-2'-deoxydihydroadenosine; 8-Oxo-7,8-dihydro-2'-deoxyadenosine. Grades: Highly Purified. CAS No. 62471-63-0. Pack Sizes: 10mg. Molecular Formula: C10H13N5O4, Molecular Weight: 267.24. US Biological Life Sciences. | Worldwide |
| 8-Oxo-2'-deoxyadenosine | 8-Oxo-2'-deoxyadenosine is a crucial product in the biomedical industry used for studying and treating oxidative DNA damage caused by reactive oxygen species. It is a modified form of the nucleoside adenosine and serves as a biomarker for DNA damage and oxidative stress-related diseases like cancer, neurodegenerative disorders, and cardiovascular diseases. Synonyms: 2'-Deoxy-8-oxo-adenosine; 8-Oxo-dA; 6-AMINO-9-[(2R,4S,5R)-4-HYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-7H-PURIN-8-ONE; 8-Oxo-7,8-dihydro-2'-deoxyadenosine; 8-Oxo-deoxyadenosine; 8-hydroxy-2'-deoxyadenosine; 6-amino-9-[(4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-7H-purin-8-one. Grade: ≥ 95%. CAS No. 62471-63-0. Molecular formula: C10H13N5O4. Mole weight: 267.24. | |
| 8-Oxo-2'-deoxyadenosine-13C2,15N | Isotope labelled 8-Oxo-2'-deoxyadenosine, the first example of a native DNA lesion that stabilizes human telomeric G-quadruplex DNA. Synonyms: 2'-Deoxy-7,8-dihydro-8-oxo-adenosine-13C2,15N; 2'-Deoxy-7,8-dihydroadenosin-8-one-13C2,15N; 7,8-Dihydro-8-oxodeoxyadenosine-13C2,15N; 8-Oxo-7,8-dihydro-2'-deoxyadenosine-13C2,15N. Grade: 95%; >90% atom 13C, 15N. Molecular formula: C8[13C]2H13N4[15N]O4. Mole weight: 270.22. | |
| 8-Oxo-2'-deoxyguanosine | 8-Oxo-2'-deoxyguanosine is a crucial biomarker to evaluate oxidative DNA damage in research of related diseases such as cancer and neurodegenerative disorders. It is an oxidized nucleoside known for its ability to accurately measure the level of oxidative stress. Synonyms: 8-Oxo-dG; 8-Hydroxy-2'-deoxyguanosine; 8-Hydroxydeoxyguanosine. Grade: ≥ 98%. CAS No. 88847-89-6. Molecular formula: C10H13N5O5. Mole weight: 283.24. | |
| 8-Oxo-2'-deoxyguanosine-[13C,15N2] | 8-Oxo-2'-deoxyguanosine-[13C,15N2] is the labelled analogue of 8-Oxo-2'-deoxyguanosine, which is a marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis and could induce differentiation of Friend murine erythroleukemia cells in vitro. Synonyms: 8-Oxo-7,8-dihydrodeoxyguanosine-13C,15N2; 8-Oxo-2'-deoxyguanosine-13C,15N2; 8-Hydroxy-2'-deoxyguanosine-13C,15N2; 2'-Deoxy-7,8-dihydro-8-oxo-guanosine-13C,15N2; 8-Oxo-7,8-dihydro-2'-deoxyguanosine-13C,15N2; 8-Oxo-dG-13C,15N2. Grade: 95%. Molecular formula: C9[13C]H13N3[15N]2O5. Mole weight: 286.22. | |
| 8-Oxo-2'-deoxyguanosine-13C,15N2 5'-Triphosphate Triethylamine Salt | 8-Oxo-2'-deoxyguanosine-13C,15N2 5'-Triphosphate is labelled 8-Oxo-2'-deoxyguanosine-5'-Triphosphate which is considered mutagenic dNTPs that can be incorporated into DNA by PCR using standard Taq polymerase. Synonyms: 8-Oxo-7,8-dihydro-2'-deoxyguanosine-13C,15N2 5'-triphosphate; 8-Oxo-dGTP-13C,15N2 Triethylamine Salt; 8-Oxo-deoxyguanosine-13C,15N2 triphosphate Triethylamine Salt. Molecular formula: C9[13C]H16N3[15N]2O14P3 xC6H15N. Mole weight: 526.16. | |
| 8-Oxo-2'-deoxyguanosine 5'-Triphosphate Triethylamine Salt | 8-Oxo-2'-deoxyguanosine-5'-Triphosphate, considered mutagenic dNTPs, it can be incorporated into DNA by PCR using standard Taq polymerase. Synonyms: 2'-Deoxy-7,8-dihydro-8-oxo-guanosine 5'-(tetrahydrogen triphosphate) Triethylamine Salt; 8-Hydroxy-2'-deoxyguanosine 5'-triphosphate Triethylamine Salt; 8-Oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate Triethylamine Salt; 8-Oxo-dGTP Triethylamine Salt; 8-Oxo-deoxyguanosine triphosphate Triethylamine Salt. Molecular formula: C10H16N5O14P3 xC6H15N. Mole weight: 523.18. | |
| 8-Oxo-7-thioguanosine | 8-Oxo-7-thioguanosine. Group: Biochemicals. Grades: Highly Purified. CAS No. 122970-43-8. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C10H12N4O6S. US Biological Life Sciences. | Worldwide |
| 8-oxo-8-(p-tolylamino)octanoic acid | 8-oxo-8-(p-tolylamino)octanoic acid. Product ID: ACMA00008282. Molecular formula: C15H21NO3. Mole weight: 263.33214. Alfa Chemistry - ISO 9001:32057 Certified. | |
| 8-Oxoadenoosine-5'-Triphosphate | 8-Oxoadenosine-5'-Triphosphate, an ATP analog crucial for cell signaling and energy transfer, is integral to studying signal transduction pathways and disease mechanisms. It also aids in the DNA sequencing and mutagenesis studies through its ability to incorporate into DNA strands. Its widespread use in research has contributed to unravelling the mysteries hidden within cancer, inflammation, and neurological disorders. Synonyms: 8-Oxo-ATP; 8-Oxo-Adenosine-5'-Triphosphate. Grade: ≥95% by AX-HPLC. CAS No. 68745-44-8. Molecular formula: C10H16N5O14P3. Mole weight: 523.10. | |
| 8-Oxoadenosine | It is an anticancer antibiotic, oxidized nucleic acid adduct and phosmidosine precursor (P-prodrug). It can be used to treat hemochromatosis. Synonyms: NSC 102240; NSC 90396; 7,8-Dihydro-8-oxoadenosine; 8-Hydroxyadenosine; 8-Oxo-7,8-dihydroadenosine; 6-Amino-7,9-dihydro-9-β-D-ribofuranosyl-8H-purin-8-one; 6-amino-9-(beta-D-ribofuranosyl)purin-8-(7H)-one; (2R,3R,4S,5R)-2-(6-amino-8-hydroxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol; 8-Hydroxyadenosine. Grade: ≥95%. CAS No. 29851-57-8. Molecular formula: C10H13N5O5. Mole weight: 283.24. | |
| 8-Oxo-Benzygluanine-d5 | 8-Oxo-Benzygluanine-d5. Synonyms: 2-Amino-7,9-dihydro-6-(phenylmethoxy)-8H-purin-8-one-d5. Molecular formula: C12H6D5N5O2. Mole weight: 262.28. | |
| 8-Oxo-Benzylguanine | As a derivative of O-Benzylguanine, 8-Oxo-Benzylguanine is a reversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase and O-Benzylguanine is known to assist in the protection against carcinogenic and therapeutic alkylating agents. Synonyms: 2-Amino-7,9-dihydro-6-(phenylmethoxy)-8H-purin-8-one; NU 6043. CAS No. 158754-46-2. Molecular formula: C12H11N5O2. Mole weight: 257.25. | |
| 8-Oxo-Benzylguanine | 8-Oxo-Benzylguanine is a derivative of O-Benzylguanine, an reversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. O-Benzylguanine is known to assists in the protection against carcinogenic and therapeutic alkylating agents. Group: Biochemicals. Alternative Names: 2-Amino-7,9-dihydro-6-(phenylmethoxy)-8H-purin-8-one; NU 6043. Grades: Highly Purified. CAS No. 158754-46-2. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| 8-oxocoformycin reductase | Si-specific with respect to NADPH. Also reduces 8-oxodeoxy-coformycin to the nucleoside antibiotic deoxycoformycin. Group: Enzymes. Synonyms: 8-ketodeoxycoformycin reductase. Enzyme Commission Number: EC 1.1.1.235. CAS No. 114995-16-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0142; 8-oxocoformycin reductase; EC 1.1.1.235; 114995-16-3; 8-ketodeoxycoformycin reductase. Cat No: EXWM-0142. |  |
| 8-Oxo-dATP | 8-Oxo-dATP is a nucleotide analog mainly acting as a substrate for DNA polymerase during DNA enhancement and repair. 8-Oxo-dATP is involved in cellular processes related to oxidative stress and DNA damage. It can be used to study the effects of oxidative DNA damage and its association with diseases such as cancer and neurodegenerative disorders. Synonyms: 8-Oxo-2'-deoxyadenosine-5'-Triphosphate; 8-Hydroxy-2'-deoxyadenosine 5'-triphosphoric acid. Grade: ≥ 95% by HPLC. Molecular formula: C10H16N5O13P3 (free acid). Mole weight: 507.18 (free acid). | |
| 8-Oxo-desacetylated famciclovir | An impurity of Famciclovir. Famciclovir is used for the treatment of various herpesvirus infections, most commonly for herpes zoster. Synonyms: 4-(2-amino-8-oxo-7H-purin-9(8H)-yl)-2-(hydroxymethyl)butyl acetate. Grade: > 95%. Molecular formula: C12H17N5O4. Mole weight: 295.30. | |
| 8-oxo-dG-CE Phosphoramidite | 8-oxo-dG-CE Phosphoramidite is an indispensable compound assuming a pivotal role in oligonucleotide research and development. Its contributes to the exploration of therapeutic drugs aimed at DNA repair and ailments associated with oxidative stress. Synonyms: 5'-Dimethoxytrityl-N2-isobutyryl-8-oxo-deoxyguanosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 8-OXO-dG(ibu) Phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-8-oxo-2'-deoxyguanosine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; (2R,3S,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6,8-dioxo-1,6,7,8-tetrahydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; DNA 8-oxo-G(iBu) amidite. Grade: 95%. CAS No. 143060-53-1. Molecular formula: C44H54N7O9P. Mole weight: 855.93. | |
| 8-OXO-dG(dmf) Phosphoramidite | 8-OXO-dG(dmf) Phosphoramidite is a modified phosphoramidite in which the guanine base is oxidized at the 8-position to form 8-oxo-guanine, with the exocyclic amine at the 2-position protected by a dimethylformamidine (dmf) group. The sugar moiety is functionalized with a 3'-cyanoethyl (CE) phosphoramidite group for incorporation into oligonucleotides via automated DNA synthesis. This modification mimics oxidative DNA damage, making it a valuable tool for studying the biological effects of oxidative stress, DNA repair mechanisms, and mutagenesis. It is widely used in molecular biology and biochemistry research to investigate the role of 8-oxo-guanine in genomic stability and disease processes. Synonyms: OXO-dG(N-dmf) Phosphoramidite; OXO-dG(N-dmf) CE Phosphoramidite; 5'-Dimethoxytrityl-N2-dimethylformamidine-8-oxo-deoxyguanosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 8-OXO-2'-deoxy-G(DMF) Phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-N2-dimethylformamidine-8-oxo-2'-deoxyguanosine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; 8-OXO-dG(dmf) CE Phosphoramidite; 8-OXO-dG(dmf) 3'-CE Phosphoramidite. Grade: ≥98%. CAS No. 1850359-96-4. Molecular formula: C43H53N8O8P. Mole weight: 840.92. | |
| 8-Oxo-dGDP | 8-Oxo-dGDP, a nucleotide analog, serves as a substrate for DNA polymerases and as a regulator for those enzymes associated with DNA repair in biochemical studies. Furthermore, it is employed to explore the involvement of oxidative stress in cancer and neurodegenerative diseases, such as Alzheimer's and Parkinson's. Synonyms: 8-Oxo-2'-deoxyguanosine-5'-diphosphate, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C10H15N5O11P2 (free acid). Mole weight: 443.20 (free acid). | |
| 8-oxo-dGDP phosphatase | The enzyme catalyses the hydrolysis of both 8-oxo-dGDP and 8-oxo-GDP thereby preventing translational errors caused by oxidative damage. The preferred in vivo substrate is not known. The enzyme does not degrade 8-oxo-dGTP and 8-oxo-GTP to the monophosphates (cf. EC 3.6.1.55, 8-oxo-dGTP diphosphatase). Ribonucleotide diphosphates and deoxyribonucleotide diphosphates are hydrolysed with broad specificity. The bifunctional enzyme NUDT5 also hydrolyses ADP-ribose to AMP and D-ribose 5-phosphate (cf. EC 3.6.1.13, ADP-ribose diphosphatase). The human enzyme NUDT18 also hydrolyses 8-oxo-dADP and 2-hydroxy-dADP, the latter at a slower rate. Group: Enzymes. Synonyms: NUDT5; MTH3 (gene name); NUDT18. Enzyme Commission Number: EC 3.6.1.58. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4630; 8-oxo-dGDP phosphatase; EC 3.6.1.58; NUDT5; MTH3 (gene name); NUDT18. Cat No: EXWM-4630. | |
| 8-Oxo-dGMP | 8-Oxo-dGMP is a nucleotide derivative commonly used in research to study DNA damage and repair mechanisms. It is often used to detect and quantify oxidation damage to DNA induced by reactive oxygen species, as well as to investigate the role of 8-oxo-dG in mutagenesis and carcinogenesis. 8-Oxo-dGMP has potential therapeutic applications for the treatment of diseases associated with oxidative stress, such as cancer and neurodegenerative disorders. Synonyms: 8-Oxo-2'-deoxyguanosine-5'-monophosphate, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C10H14N5O8P (free acid). Mole weight: 363.22 (free acid). | |
| 8-Oxo-dGP4 | 8-Oxo-dGP4 is a chemical compound used in biomedical research for the study of DNA damage and repair mechanisms. It is a modified form of the nucleoside guanosine and is commonly utilized to identify and quantify oxidative damage to DNA caused by reactive oxygen species. Additionally, 8-Oxo-dGP4 has potential in the development and screening of drugs for the treatment of diseases related to DNA damage, such as cancer and neurodegenerative disorders. Synonyms: 8-Oxo-2'-deoxyguanosine-5'-tetraphosphate, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C10H17N5O17P4 (free acid). Mole weight: 603.16 (free acid). | |
| 8-Oxo-dGTP | 8-Oxo-dGTP can increase the rate of genetic mutation via interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. Uses: 8-oxo-dgtp is an agent that increase the rate of genetic mutation. Synonyms: 8-Oxo-2'-deoxyguanosine-5'-Triphosphate; 8-Oxodeoxyguanosine triphosphate; 8-Oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. Grade: ≥95% by AX-HPLC. CAS No. 139307-94-1. Molecular formula: C10H16N5O14P3 (free acid). Mole weight: 523.18 (free acid). | |
| 8-oxo-dGTP diphosphatase | This enzyme hydrolyses the phosphoanhydride bond between the α and β phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA. It does not hydrolyse 2-hydroxy-dATP (cf. EC 3.6.1.56, 2-hydroxy-dATP diphosphatase). Requires Mg2+. Group: Enzymes. Synonyms: MutT; 7,8-dihydro-8-oxoguanine triphosphatase; 8-oxo-dGTPase; 7,8-dihydro-8-oxo-dGTP pyrophosphohydrolase. Enzyme Commission Number: EC 3.6.1.55. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4627; 8-oxo-dGTP diphosphatase; EC 3.6.1.55; MutT; 7,8-dihydro-8-oxoguanine triphosphatase; 8-oxo-dGTPase; 7,8-dihydro-8-oxo-dGTP pyrophosphohydrolase. Cat No: EXWM-4627. | |
| 8-Oxo-GTP | 8-Oxo-GTP, a nucleotide with modifications, is a valuable tool in discovering RNA oxidative and repair mechanisms. Its versatile use also includes investigations into Alzheimer's and Parkinson's, as well as cancer. Its potential to provide antioxidant properties demonstrates promise for defending against oxidative stress in various disease states. Synonyms: 8-Oxoguanosine-5'-Triphosphate; 7,8-Dihydro-8-oxoguanosine 5'-(tetrahydrogen triphosphate); Purine-6,8(1H,9H)-dione, 2-amino-9-β-D-ribofuranosyl-, 5'-(tetrahydrogen triphosphate); 8-Ketoguanosine 5'-triphosphate. Grade: ≥95% by HPLC. CAS No. 21238-36-8. Molecular formula: C10H16N5O15P3. Mole weight: 539.18. | |
| 8-oxoguanine deaminase | Zn2+ is bound in the active site. 8-Oxoguanine is formed via the oxidation of guanine within DNA by reactive oxygen species. If uncorrected, this modification leads to the incorporation of 8-oxoG:A mismatches and eventually to G:C to T:A transversions. Group: Enzymes. Synonyms: 8-OGD. Enzyme Commission Number: EC 3.5.4.32. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4560; 8-oxoguanine deaminase; EC 3.5.4.32; 8-OGD. Cat No: EXWM-4560. | |
| 8-Oxoguanosine | 8-Oxoguanosine. Group: Biochemicals. Alternative Names: 8-Hydroxy-D-guanosine. Grades: Highly Purified. CAS No. 3868-31-3. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C10H13N5O6. US Biological Life Sciences. | Worldwide |
| 8-Oxo-N2-isobutyryl-2'-deoxyguanosine | 8-Oxo-N2-isobutyryl-2'-deoxyguanosine is an exceptional biomedical compound, rendered as a discerning indicator for DNA impairment. It assumes an integral role as a substrate for DNA reparation. Its utilization propels extensive investigation into oxidative species-induced DNA lesions, thereby furnishing profound elucidation into an array of afflictions spanning cancer to neurodegenerative disorders. Synonyms: 8-HYDROXY-N2-ISOBUTRYL-2'-DEOXYGUANOSINE; 8-HYDROXY-N2-ISOBUTRYL-2/'-DEOXYGUANOSINE; N-[9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,8-dioxo-1,7-dihydropurin-2-yl]-2-methylpropanamide; DTXSID40721580; MFCD22373349; N2-Isobutyryl-8-oxo-2'-deoxyguanosine; 2'-Deoxy-N-(2-methylpropanoyl)-8-oxo-7,8-dihydroguanosine; N-(8-hydroxy-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide. Grade: ≥ 90%. CAS No. 136859-76-2. Molecular formula: C14H19N5O6. Mole weight: 353.33. | |
| 8-OXO-OCTANOIC ACID ETHYL ESTER | 8-OXO-OCTANOIC ACID ETHYL ESTER. Product ID: ACMA00008263. Molecular formula: C10H18O3. Mole weight: 186.25. Alfa Chemistry - ISO 9001:32057 Certified. | |
| 8-pCPT-2'-O-Me-5'-AMP | 8-pCPT-2'-O-Me-5'-AMP is a potential metabolite of 8-pCPT-2'-O-Me-cAMP, the specific Epac activator. Synonyms: 8-(4-Chlorophenylthio)-2'-O-methyladenosine-5'-O-monophosphate, sodium salt. Grade: ≥ 97% by HPLC. CAS No. 1187179-94-7. Molecular formula: C17H19ClN5O7PS (free acid). Mole weight: 503.85 (free acid). | |
| 8-pCPT-2'-O-Me-Ado | 8-pCPT-2'-O-Me-Ado is the potential metabolite of 8-pCPT-2'-O-Me-cAMP, a specific Epac activator. Synonyms: 8- (4- Chlorophenylthio)- 2'- O- methyladenosine. Grade: ≥ 98% by HPLC. CAS No. 1187179-96-9. Molecular formula: C17H18ClN6O4S. Mole weight: 423.9. | |
| 8-pCPT-2'-O-Me-cAMP | 8-pCPT-2'-O-Me-cAMP is a PDE-stable activator of the exchange protein activated by cAMP (Epac) or cAMP-GEF, which does not activate protein kinase A. It has high lipophilicity and membrane permeability. Synonyms: 8- (4- Chlorophenylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥98% by HPLC. CAS No. 634207-53-7. Molecular formula: C17H16ClN5O6PS · Na. Mole weight: 507.8. | |
| 8-pCPT-2'-O-Me-cAMP-AM | 8-pCPT-2'-O-Me-cAMP-AM is a precursor of 8-pCPT-2'-O-Me-cAMP, the specific Epac agonist. 8-pCPT-2'-O-Me-cAMP is released after the metabolism of 8-pCPT-2'-O-Me-cAMP-AM by esterases. Synonyms: 8- (4- Chlorophenylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester. Grade: ≥ 97% by HPLC for mixture of isomers. CAS No. 1152197-23-3. Molecular formula: C20H21ClN5O8PS. Mole weight: 557.9. | |
| 8-pCPT-2-O-Me-cAMP sodium | 8-pCPT-2-O-Me-cAMP (8-CPT-2'-O-Me-cAMP) sodium, an analog of cAMP, is an activator of exchange proteins activated by cAMP (Epac). 8-pCPT-2-O-Me-cAMP sodium activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 >10 μM). 8-pCPT-2-O-Me-cAMP sodium stimulates Epac-mediated Ca2+ release in pancreatic β-cells in vitro. 8-pCPT-2-O-Me-cAMP sodium is a Rap1 activator. 8-pCPT-2-O-Me-cAMP sodium enhances the retinal pigment epithelium barrier against the pathological choroidal endothelial cell invasion that occurs in macular degeneration[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 8-CPT-2'-O-Me-cAMP sodium. CAS No. 634207-53-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107543. | |
| 8-pCPT-2'-O-Me-cGMP | 8-pCPT-2'-O-Me-cGMP is a PDE-stable, high lipophilic and membrane-permeant analogue. It can be used as a control since it has no activated effect on protein kinase G or Epac. Synonyms: 8- (4- Chlorophenylthio)- 2'- O- methylguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 98% by HPLC. CAS No. 625112-42-7. Molecular formula: C17H16ClN5O7PS · Na. Mole weight: 523.8. | |
| 8-pCPT-2'-O-Me-cXMP | 8-pCPT-2'-O-Me-cXMP can be used as a control since it has no activated effect on protein kinase G or Epac. Synonyms: 8- (4- Chlorophenylthio)- 2'- O- methylxanthosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 98% by HPLC. Molecular formula: C17H15ClN4O8PS · Na. Mole weight: 524.8. | |
| 8-pCPT-2'-O-Me-Guo | 8-pCPT-2'-O-Me-Guo is the potential metabolite of the PKG- and Epac-inactive cGMP analogue8-pCPT-2'-O-Me-cGMP. Synonyms: 8- (4- Chlorophenylthio)- 2'- O- methylguanosine. Grade: ≥ 97 % by HPLC. CAS No. 966936-60-6. Molecular formula: C17H18ClN6O6S. Mole weight: 439.9. | |
| 8-pCPT-5'-AMP | 8-pCPT-5'-AMP is a potential metabolite of 8-pCPT-cAMP that inhibits 5'-IMP dehydrogenase. Synonyms: 8-(4-chlorophenylthio)adenosine-5'-O-monophosphate. Grade: ≥ 97 % by HPLC. CAS No. 78710-84-6. Molecular formula: C16H17ClN5O7PS. Mole weight: 489.83. | |
| 8-pCPT-Ado | 8-pCPT-Ado is the potential metabolite of 8-CPT-cAMP. Synonyms: 8- (4- Chlorophenylthio)adenosine. Grade: ≥ 97 % by HPLC. CAS No. 86362-87-0. Molecular formula: C16H16ClN6O4S. Mole weight: 409.9. | |
| 8-pCPT-cGMP | 8-pCPT-cGMP is a selective activator of cGMP-dependent protein kinase type I α and type II, as well as of cGMP-gated ion channels. It has higher membrane permeability and stability towards many phosphodiesterases. Synonyms: 8- (4- Chlorophenylthio)guanosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 99% by HPLC. CAS No. 51239-26-0. Molecular formula: C16H14ClN5O7PS · Na. Mole weight: 509.8. | |
| 8-pCPT-cGMP-AM | 8-pCPT-cGMP-AM is a precursor of 8-pCPT-cGMP, the PKG activator. 8-pCPT-cGMP is released after the metabolism of 8-pCPT-cGMP-AM by esterases. Synonyms: 8- (4- Chlorophenylthio)guanosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester. Grade: ≥ 97% by HPLC for mixture of isomers. CAS No. 272445-72-4. Molecular formula: C19H19ClN5O9PS. Mole weight: 559.9. | |
| 8-Pcpt-cGMP sodium | 8-Pcpt-cGMP sodium is the sodium salt form of 8-Pcpt-cGMP (HY-137016). 8-Pcpt-cGMP sodium is an agonist for cyclic nucleotide-gated (CNG) channel with an EC50 of 0.5 μM. 8-Pcpt-cGMP sodium exhibits good membrane permeability. 8-Pcpt-cGMP sodium can be used in studies about the function of CNG channels in visual signal transduction and olfactory transduction[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 51239-26-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-137016A. | |
| 8-pCPT-Guo | 8-pCPT-Guo, a remarkable agonist with potent effects on the adenosine receptors, specifically targeting adenosine A1R and A3R. Scientific research has found it instrumental in exploring the diverse physiological mechanisms of these receptors. Furthermore, the drug holds immense potential as a treatment option for a range of debilitating conditions such as inflammation, cancer, and neurological disorders. With its multidimensional qualities, 8-pCPT-Guo stands as a compelling player in the medical research landscape. Molecular formula: C16H16ClN6O6S. Mole weight: 426.9. | |
| 8-pCPT-PET-cGMP | 8-pCPT-PET-cGMP is an activator of cyclic GMP-dependent protein kinase as well as an inhibitor of the retinal type cGMP-gated ion channel, thus it can be used for distinction between kinase and ion channel mediated effects. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to 8-Br-PET-cGMP, 8-pCPT-PET-cGMP is much more lipophilic and membrane-permeant. Synonyms: 8- (4- Chlorophenylthio)- β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 98% by HPLC. Molecular formula: C24H18ClN5O7PS · Na. Mole weight: 609.9. | |
| 8-phenyl-1-naphthalenyl boronic acid | 8-phenyl-1-naphthalenyl boronic acid. CAS No. 181135-36-4. Molecular formula: C16H13BO2. Mole weight: 248.1g/mol. IUPAC Name: (8-phenylnaphthalen-1-yl)boronic acid. SMILES: B(C1=C2C(=CC=C1)C=CC=C2C3=CC=CC=C3)(O)O. InChI: InChI=1S/C16H13BO2/c18-17(19)15-11-5-9-13-8-4-10-14(16(13)15)12-6-2-1-3-7-12/h1-11,18-19H. |  |
| 8-Phenylnaphthalene-1-carbonitrile | 8-Phenylnaphthalene-1-carbonitrile. Alternative Names: 8-Phenylnaphthalene-1-carbonitrile. CAS No. 1071039-54-7. Purity: 96%. Product ID: ACM1071039547. Molecular formula: C17H11N. Mole weight: 229.27594. IUPAC Name: 8-phenylnaphthalene-1-carbonitrile. Alfa Chemistry - ISO 9001:32057 Certified. | |
| 8-Phenylnaphthalene-1-carboxylic acid | 8-Phenylnaphthalene-1-carboxylic acid. Alternative Names: 8-Phenylnaphthalene-1-carboxylic acid. CAS No. 130818-32-5. Purity: 96%. Product ID: ACM130818325. Molecular formula: C17H12O2. Mole weight: 248.27598. IUPAC Name: 8-phenylnaphthalene-1-carboxylic acid. Alfa Chemistry - ISO 9001:32057 Certified. | |
| 8-Phenylnaphthalene-2-carboxylic acid | 8-Phenylnaphthalene-2-carboxylic acid. Alternative Names: 8-Phenylnaphthalene-2-carboxylic acid. CAS No. 144119-86-8. Purity: 96%. Product ID: ACM144119868. Molecular formula: C17H12O2. Mole weight: 248.27598. IUPAC Name: 8-phenylnaphthalene-2-carboxylic acid. Alfa Chemistry - ISO 9001:32057 Certified. | |
| 8-Phenyloctylazanium nitrate | 8-Phenyloctylazanium nitrate. CAS No. 120375-41-9. Product ID: ACM120375419. Alfa Chemistry - ISO 9001:32057 Certified. | |
| 8-[φ-450]-cAMP | 8-[φ-450]-cAMP can be used for studies with intact cells for its excellent lipophilicity and bright green fluorescence. Synonyms: 8-[Pharos-450]-adenosine-3',5'-cyclic monophosphate. Grade: ≥ 98% by HPLC. | |
| 8-[φ-450]-cGMP | 8-[φ-450]-cGMP can be used for studies with intact cells for its excellent lipophilicity and bright green fluorescence. Synonyms: 8-[Pharos-450]-guanosine-3',5'-cyclic monophosphate. Grade: ≥ 98% by HPLC. | |
| 8-[φ-575]-2'-O-Me-cAMP | 8-[φ-575]-2'-O-Me-cAMP can be used for studies with intact cells for its excellent lipophilicity and bright red fluorescence. Synonyms: 8-[Pharos-575]-2'-O-methyladenosine-3',5'-cyclic monophosphate. Grade: ≥ 98% by HPLC. Mole weight: 731. | |
| 8-[φ-575]-cAMP | 8-[φ-575]-cAMP can be used for studies with intact cells for its excellent lipophilicity and bright red fluorescence. A tiny hypsochromic shift would be developed while binding to PKA. Synonyms: 8-[Pharos-575]-adenosine-3',5'-cyclic monophosphate. Grade: ≥ 98% by HPLC. | |
| 8-[φ-575]-cGMP | 8-[φ-575]-cGMP is a fuorescent analogue of cGMP, which can be used for studies with intact cells on account of its high lipophilicity and bright red fluorescence. Synonyms: 8-[Pharos-575]-guanosine-3',5'-cyclic monophosphate. Grade: ≥ 98% by HPLC. Mole weight: 500.4. | |
| 8-pHPT-2'-O-Me-cAMP | 8-pHPT-2'-O-Me-cAMP is an activator of the exchange protein activated by cAMP (Epac) or cAMP-GEF, which does not activate protein kinase A. It has superior lipophilicity, membrane permeability and PDE stability. Synonyms: 8- (4- Hydroxyphenylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate , sodium salt. Grade: ≥ 98% by HPLC. CAS No. 612513-15-2. Molecular formula: C17H17N5O7PS · Na. Mole weight: 489.4. | |
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