A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Avermectin B1. Group: Biochemicals. Grades: Highly Purified. CAS No. 71751-41-2. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C49H74O14. US Biological Life Sciences.
Worldwide
Avermectin B1a
It is produced by the strain of Streptomyces avermitilis. Avermectin B1a is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis. It is a macrocyclic lactone that makes up a large component of the anthelimintic Abamectin used to control parasitic nematodes in livestock. It also acts as an insecticide and acaricide. Uses: Active ingredient in some commercial ant bait traps. Synonyms: Ivermectin EP Impurity A; Abamectin B1a; Doramectin Impurity 3. Grade: ≥95%. CAS No. 65195-55-3. Molecular formula: C48H72O14. Mole weight: 873.08.
Avermectin B1a
Avermectin B1a. Group: Biochemicals. Grades: Highly Purified. CAS No. 65195-55-3. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C48H72O14. US Biological Life Sciences.
Worldwide
Avermectin B1a
Avermectin B1a is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Abamectin B1a. CAS No. 65195-55-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15308.
Avermectin B1a (5-O-Demethylavermectin A1a, Antibiotic C 076B1a)
Avermectin B1a is the major component (>80%) of the commerically available anthelmintic Abamectin (R) used to control parasitic nematodes in livestock. Avermectin B1a contains a secbutyl residue in the 24-position. In vitro and in vivo studies have shown this analogue is the more potent analogue in the commerical product. Group: Biochemicals. Alternative Names: 5-O-Demethylavermectin A1a, Antibiotic C 076B1a. Grades: Highly Purified. CAS No. 65195-55-3. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Avermectin B1a aglycone
It is an acid degradation product produced by hydrolysis of the disaccharide unit of avermectin. It is an inhibitor of nematode larval development. It has no paralytic activity. It is an anthelmintic in animal health. Synonyms: (6R,13S,25R)-22,23-didehydro-5-O-demethyl-28-deoxy-6,28-epoxy-13-hydroxy-25-[(1S)-1-methylpropyl]-milbemycin B. Grade: >95% by HPLC. CAS No. 71828-14-3. Molecular formula: C34H48O8. Mole weight: 584.74.
Avermectin b1a ≥95% (HPLC)
Avermectin b1a ≥95% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g, 2.5g. US Biological Life Sciences.
Worldwide
Avermectin B1a monosaccharide
It is an acid degradation product produced by selective hydrolysis of the terminal saccharide unit of avermectin. It is a potent inhibitor of nematode larval development. It has no paralytic activity. Synonyms: 4'-O-de(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-5-O-demethyl-avermectin A1a; 5-O-Demethyl-4'-O-de(2,6-dideoxy-3-O-methyl-α-L-glucopyranosyl)avermectin A1a; MSB 1a. Grade: >95% by HPLC. CAS No. 71831-09-9. Molecular formula: C41H60O11. Mole weight: 728.91.
Avermectin B1b
Avermectin B1b is the minor component of the commercially available anthelmintic marketed as Abamectin. It is used broadly against nematodes, ticks, flies, and ants. Synonyms: Ivermectin EP Impurity B; 5-O-Demethyl-25-de(1-methylpropyl)-25-(1-methylethyl)-avermectin A1a; Doramectin Impurity 2. Grade: ≥95%. CAS No. 65195-56-4. Molecular formula: C47H70O14. Mole weight: 859.05.
Avermectin B1b (Antibiotic C 076B1b)
Avermectin B1b is the minor component (<20%) of the commerically available anthelmintic marketed as Abamectin(R) used to control parasitic nematodes in livestock. Avermectin B1b contains a isopropyl residue in the 24-position. In vitro and in vivo studies have shown this analogue to be active but less potent than the B1a analogue. Group: Biochemicals. Alternative Names: Antibiotic C 076B1b. Grades: Highly Purified. CAS No. 65195-56-4. Pack Sizes: 500ug. US Biological Life Sciences.
Worldwide
Avermectin B2a
Avermectin B2a is produced by the strain of Streptomyces avermitilis. It stimulates nerve cells to release Y-aminobutyric acid (GABA), which blocks the transmission of signals from the central nervous system to the motor nerve. It is not resistant to bacteria and fungi, but has strong activity to nematode parasites such as ancylostoma and Pteria, as well as insects such as flies. Abamectin B1a has the highest activity. Ivermectin obtained by catalytic hydrogenation contains 22 23- dihydroabamectin B1a (above 80%) and 22 23 dioxabamectin B1b (below 20%). Less active than B1a but less toxic. Used as repellent (subcutaneous or oral) for cattle, sheep and pigs, it is also effective against human filariasis. Synonyms: Ivermectin EP Impurity C; (23S)-5-O-demethyl-23-hydroxy-22,23-dihydro-avermectin A1a. CAS No. 65195-57-5. Molecular formula: C48H74O15. Mole weight: 891.09.
avermitilol synthase
Requires Mg2+. The recombinent enzyme gives avermitilol (85%) plus traces of germacrene A, germacrene B and viridiflorol. The (1S)-hydrogen of farnesyl diphosphate is retained. Group: Enzymes. Enzyme Commission Number: EC 4.2.3.96. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5260; avermitilol synthase; EC 4.2.3.96. Cat No: EXWM-5260.
Averufin
Averufin is produced by the strain of Asergillus sp. Ames tests showed a weak mutagenic effect. Synonyms: Averufine; 3,4,5,6-Tetrahydro-7,9,11-trihydroxy-2-methyl-2,6-epoxy-2H-anthra[2,3-b]oxocin-8,13-dione. CAS No. 14016-29-6. Molecular formula: C20H16O7. Mole weight: 368.34.
a-Vi-5
a-Vi-5. Uses: Designed for use in research and industrial production. Additional or Alternative Names: A-VI-5;Bradykinin potentiating factor alpha-vi-5. Product Category: Heterocyclic Organic Compound. CAS No. 39194-96-2. Molecular formula: C22H40N6O10. Mole weight: 548.59. Purity: 0.96. IUPACName: 6-amino-2-[[2-[[2-[[2-[(2-amino-3-methylbutanoyl)amino]-5-hydroxy-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]hexanoic acid. Canonical SMILES: CC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(CO)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)O)N. Density: 1.34g/cm³. Product ID: ACM39194962. Alfa Chemistry ISO 9001:2015 Certified. Categories: A-Vi-Pel.
Avian Eggshell Membrane Collagen
Avian Eggshell Membrane Collagen.
CA, FL & NJ
Avibactam
Avibactam is a novel investigational non-beta-lactam beta-lactamase inhibitor that is being developed for possible use in combination with ceftaroline in the U.S. Avibactam does not have any intrinsic antibacterial activity in its own right, but appears to be capable of inhibiting beta-lactamase enzymes that belong to molecular classes A and C.Avibactam is useful for Antibiotics. Uses: Beta-lactamase inhibitors. Synonyms: Sulfuric acid mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester; Avibactam free acid; [(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate. Grade: >98%. CAS No. 1192500-31-4. Molecular formula: C7H11N3O6S. Mole weight: 265.24.
Avibactam free acid
Avibactam (NXL-104) free acid is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC 50 s of 8 nM and 5 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NXL-104 free acid. CAS No. 1192500-31-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14879.
Avibactam Impurity 11
Avibactam Impurity 11 is an impurity of Avibactam. Synonyms: Avibactam Impurity 11; 1416134-60-5; Ethyl 5-phenylmethoxyiminopiperidine-2-carboxylate; Avibactam Impurity 15; (S,E)-ethyl 5-((benzyloxy)imino)piperidine-2-carboxylate. Grade: > 95%. CAS No. 1416134-60-5. Molecular formula: C14H18N2O3. Mole weight: 262.31.
Avibactam Impurity 27
Avibactam Impurity 27. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2S,5R)-ethyl 5-((benzyloxy)amino)piperidine-2-carboxylate oxalate. CAS No. 1416134-48-9. Molecular formula: C17H24N2O7. Mole weight: 368.38. Catalog: APB1416134489.
Avibactam Impurity 3
Avibactam Impurity 3 is an impurity of Avibactam. Synonyms: (2S,5R)-5-[(benzyloxy)amino]piperidine-2-carboxamide; 2-Piperidinecarboxamide, 5-[(phenylmethoxy)amino]-, (2S,5R)-; (2S,5R)-5-(benzyloxyamino)-piperidine-2-carboxylic acid amide; 5R-(5-Benzyloxyamino) L-Pipecolic Amide. Grade: > 95%. CAS No. 1416134-49-0. Molecular formula: C13H19N3O2. Mole weight: 249.32.
Avibactam Impurity 49
Avibactam Impurity 49. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1416134-73-0. Molecular formula: C14H20N2O3. Mole weight: 264.33. Catalog: APB1416134730.
Avibactam Impurity 6
An impurity of Avibactam, a non-β lactam β-lactamase inhibitor that inactivates some β-lactamases. Synonyms: (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; (1R,2S,5R)-7-Oxo-6-(phenylmethoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide. Grade: >95%. CAS No. 1192651-49-2. Molecular formula: C14H17N3O3. Mole weight: 275.31.
Avibactam Impurity 77
Avibactam Impurity 77. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2S,5R)-ethyl 6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylate. CAS No. 1416134-63-8. Molecular formula: C16H20N2O4. Mole weight: 304.14. Catalog: APB1416134638.
Avibactam Impurity 9
Avibactam Impurity 9 is an impurity of Avibactam. Synonyms: Avibactam Intermediate; (2S,5R)-5-[(Phenylmethoxy)amino]-2-piperidinecarboxylic Acid Ethyl Ester Ethanedioate; (2S,5R)-Ethyl 5-((benzyloxy)amino)piperidine-2-carboxylate Oxalate. Grade: > 95%. CAS No. 1416134-48-9. Molecular formula: C17H24N2O7. Mole weight: 377.39.
Avibactam Impurity N
Avibactam Impurity N. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxamide. CAS No. 1416134-49-0. Molecular formula: C13H19N3O2. Mole weight: 249.31. Catalog: APB1416134490.
Avibactam sodium
Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC 50 s of 8 nM and 5 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NXL-104. CAS No. 1192491-61-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-14879A.
Avibactam sodium
100mg Pack Size. Group: Antibiotics, Bioactive Small Molecules, Research Organics & Inorganics. Formula: C7H10N3O6S ·Na. CAS No. 1192491-61-4. Prepack ID 90023818-100mg. Molecular Weight 287.2. See USA prepack pricing.
Avibactam Sodium, (+)-
An impurity of Avibactam, a non-β lactam β-lactamase inhibitor that inactivates some β-lactamases. Synonyms: (2R,5S)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo(3.2.1)octane-2-carboxamide monosodium salt. Grade: ≥95%. CAS No. 1383814-68-3. Molecular formula: C7H10N3NaO6S. Mole weight: 287.23.
Avibactam sodium hydrate
Avibactam is a reversible β-lactamase inhibitor (IC50 = 8/80/38 nM for TEM-1/P99/KPC-2 β-lactamases). Synonyms: NXL-104 hydrate. Molecular formula: C7H12N3NaO7S. Mole weight: 305.24.
Avibactam sodium hydrate
Avibactam sodium (NXL-104) hydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC 50 s of 8 nM and 5 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NXL-104 hydrate. CAS No. 2938989-90-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-14879B.
Avibactam Sodium Salt
Avibactam Sodium Salt, a novel non-?-lactam ?-lactamase inhibitor, binds covalently to Ambler class A ?-lactamases, including KPCs, Ambler class C and some class D b-lactamases. In combination with ceftazidime, Avibactam is a new drug application for avibactam , and was approved by the FDA on February 25, 2015, to treat complicated urinary tract and complicated intra-abdominal Infections caused by antibiotic resistant-pathogens. Avibactam has limited intrinsic antimicrobial activity but restores the in vitro activity of b-lactams including ceftazidime, ceftaroline, the active metabolite of ceftaroline fosamil, and aztreonam against ESBL-producing pathogens. Synonyms: sodium (2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[321]octan-6-yl sulfate; NXL104; NXL-104; NXL 104; Avibactam; Avibactam sodium. CAS No. 1192491-61-4. Molecular formula: C7H10N3NaO6S. Mole weight: 287.23.
Avibactam tomilopil
Avibactam tomilopil (ARX-1796, AV-006) is an orally active prodrug of Avibactam and a β-lactamase inhibitor. Avibactam tomilopil can be used in the study of diseases such as urinary tract infections [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARX-1796; AV-006. CAS No. 2245880-46-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132987.
Avicularin
Avicularin, a natural plant flavonoid isolated from the herbs of Polygonum aviculare, exhibits anti-inflammatory activity through the suppression of ERK signaling pathway in LPS-stimulated RAW 264.7 macrophage cells. By decreasing C/EBPα-activated GLUT4-mediated glucose uptake in adipocytes and potently inhibiting fatty acid synthase, avicularin can inhibit the accumulation of the intracellular lipids. Uses: Anti-inflammatory. Synonyms: Fenicularin; Quercetin 3-alpha-L-arabinofuranoside; Avicularoside. Grade: >98%. CAS No. 572-30-5. Molecular formula: C20H18O11. Mole weight: 434.4.
Avicularin
Avicularin is an orally active flavonoid. Avicularin inhibits NF-κB (p65), COX-2 and PPAR-γ activities. Avicularin has anti-inflammatory, anti-infectious anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Yellow powder. CAS No. 572-30-5. Molecular formula: C20H18O11. Mole weight: 434.4. Purity: 0.98. IUPACName: 3-[(2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one. Canonical SMILES: C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(O4)CO)O)O)O)O. Product ID: ACM572305. Alfa Chemistry ISO 9001:2015 Certified.
Avicularin
Avicularin is an orally active flavonoid. Avicularin inhibits NF-κB (p65) , COX-2 and PPAR-γ activities. Avicularin has anti-inflammatory, anti-infectious anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities [1] [3]. Uses: Scientific research. Group: Natural products. CAS No. 572-30-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0222.
Avicularin
Avicularin. Group: Biochemicals. Alternative Names: Avicularoside; Fenicularin. Grades: Plant Grade. CAS No. 572-30-5. Pack Sizes: 20mg. Molecular Formula: C20H18O11, Molecular Weight: 434.35. US Biological Life Sciences.
Avidin, chicken egg white is a glycoprotein derived from egg protein. Avidin, chicken egg white has excellent affinity with biotin and is often used in combination with biotin for immunoassays to detect the location of antigens in tissues [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 1405-69-2. Pack Sizes: 5 mg. Product ID: HY-NP005.
Avidin-ferritin labeled
avidin from egg white, lyophilized powder. Group: Fluorescence/luminescence spectroscopy.
Avidinorubicin
Avidinorubicin is produced by the strain of Streptomyces avidinii. It has anti-gram positive and negative bacterial activity, and has cytotoxicity to tumor cells. Molecular formula: C60H86N4O22. Mole weight: 1215.34.
Aviglycine hydrochloride (ABG-3168) is an inhibitor of ethylene biosynthesis. The use of Aviglycine hydrochloride (ABG-3168) delays the natural flowering of pineapples, reduces fruit drop, and maintains fruit firmness [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABG-3168. CAS No. 55720-26-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W009861.
Avilamycin
Avilamycin is an antimicrobial agent that is active mainly against Gram-positive bacteria and is used against methicillin-resistant staphylococcus. Uses: Anti-bacterial agents. Synonyms: LY 048740; Maxus; Maxus 100; Maxus 200; Surmax; (2R,3S,4R,6S)-6-(((3a'R,4R,4'R,5S,6R,6'S,7a'R)-6'-(((2S,3R,4R,5S,6R)-2-(((2R,3S,4S,5S,6S)-6-(((2R,3aS,3a'R,6S,6'R,7R,7aR,7'S,7a'R)-7'-acetyl-7'-hydroxy-7-(isobutyryloxy)-6'-methyloctahydro-4H-2,4'-spirobi[[1,3]dioxolo[4,5-c]pyran]-6-yl)oxy)-4-hydroxy-5-methoxy-2-(methoxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-3-hydroxy-5-methoxy-6-methyltetrahydro-2H-pyran-4-yl)oxy)-4-hydroxy-4',6,7a'-trimethyloctahydro-4'H-spiro[pyran-2,2'-[1,3]dioxolo[4,5-c]pyran]-5-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl 3,5-dichloro-4-hydroxy-2-methoxy-6-methylbenzoate. Grade: > 95%. CAS No. 11051-71-1. Molecular formula: C61H88Cl2O32. Mole weight: 1404.24.
Avilamycin (~80%)
Avilamycin is an antimicrobial agent used against methicillin resistant Staphylococcus. Group: Biochemicals. Alternative Names: LY 048740; Maxus; Maxus 100; Maxus 200; Surmax. Grades: Highly Purified. CAS No. 11051-71-1. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??Cl?O??, Molecular Weight: 1404.24. US Biological Life Sciences.
Worldwide
Avilamycin A
Avilamycin A is produced by the strain of Streptomyces viridochromogenes NRRL 2860. It inhibits the binding of amino acid-based tRNA to the bacterial ribosome for 30S subunit and has anti-gram-positive bacterial activity. It has been tried as feed additive in animal feeding. Synonyms: Flambamycin, 23-deoxy-. CAS No. 69787-79-7. Molecular formula: C61H88Cl2O32. Mole weight: 1404.23.
Avilamycin B
Avilamycin B is produced by the strain of Streptomyces viridochromogenes NRRL 2860. It inhibits the binding of amino acid-based tRNA to the bacterial ribosome for 30S subunit and has anti-gram-positive bacterial activity. It has been tried as feed additive in animal feeding. Grade: 95%. CAS No. 73240-30-9. Molecular formula: C59H84Cl2O32. Mole weight: 1376.19.
Avilamycin C
Avilamycin C is produced by the strain of Streptomyces viridochromogenes NRRL 2860. It inhibits the binding of amino acid-based tRNA to the bacterial ribosome for 30S subunit and has anti-gram-positive bacterial activity. It has been tried as feed additive in animal feeding. Synonyms: SCHEMBL6753731. Grade: 95%. CAS No. 69787-80-0. Molecular formula: C61H90Cl2O32. Mole weight: 1406.25.
Aviptadil
Aviptadil Acetate is an analog of vasoactive intestinal polypeptide (VIP) as Vasoactive intestinal peptide receptor agonists for the treatment of erectile dysfunction. Uses: Vasoactive intestinal peptide receptor agonists. Synonyms: H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2. Grade: 98%. CAS No. 40077-57-4. Molecular formula: C147H238N44O42S. Mole weight: 3325.80.
Aviptadil
Aviptadil is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Peptides. Alternative Names: Vasoactive Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine). CAS No. 40077-57-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-P0012.
Aviptadil acetate
Aviptadil acetate is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil acetate induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil acetate can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Vasoactive Intestinal Peptide acetate salt (human, rat, mouse, rabbit, canine, porcine). CAS No. 1444827-29-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P0012A.
Avitinib
Avitinib (Abivertinib) is a third-generation, irreversible and orally active selective EGFR inhibitor, with IC 50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R , EGFR T790M and wild-type EGFR. Avitinib is also a BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma. Avitinib shows anticancer effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Abivertinib; AC0010. CAS No. 1557267-42-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19816.
Avitinib
Avitinib (AC0010) is a third generation inhibitor of the EGFR (epidermal growth factor receptor) that was permitted parallel phase I clinical trials in the US. It is a pyrrolopyrimidine-based irreversible EGFR inhibitor that is mutation-selective with IC50 value of 0.18 nM against EGFR L858R/T790M double mutations. Upon oral administration, avitinib covalently binds to and inhibits the activity of mutant forms of EGFR. Uses: Tyrosine kinase inhibitors. Synonyms: AC0010. Grade: ≥98%. CAS No. 1557267-42-1. Molecular formula: C26H26FN7O2. Mole weight: 487.5.
Avitinib maleate
Avitinib (Abivertinib) maleate is a third-generation, irreversible and orally active selective EGFR inhibitor, with IC 50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R , EGFR T790M and wild-type EGFR. Avitinib maleate is also a BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma. Avitinib maleate shows anticancer effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Abivertinib maleate; AC0010 maleate. CAS No. 1557268-88-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19816A.
Avitinib maleate
Avitinib maleate, the maleate salt form of avitinib, is a pyrrolopyrimidine-based, irreversible epidermal growth factor receptor (EGFR) mutant-selective inhibitor (IC50 = 7.68 nM), with potential antineoplastic activity. Uses: Tyrosine kinase inhibitors. Synonyms: Avitinib maleate; AC0010MA; AC-0010MA; AC 0010MA; AC0010; AC-0010; AC 0010. CAS No. 1557268-88-8. Molecular formula: C30H30FN7O6. Mole weight: 603.6.
Avitriptan
Avitriptan is an antimigraine drug of the triptan family which was never marketed. It acts as a 5-HT1B and 5-HT1D receptor agonist. Synonyms: 1-[3-[3-[4-(5-methoxypyrimidin-4-yl)piperazin-1-yl]propyl]-1H-indol-5-yl]-N-methyl-methanesulfonamide. Grade: > 95%. CAS No. 151140-96-4. Molecular formula: C22H30N6O3S. Mole weight: 458.59.
Avizakimab (BOS161721) is a humanized IgG1 monoclonal antibody that targets interleukin-21 [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BOS161721. CAS No. 2229685-51-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99451.
AVJ16
AVJ16 is a cancer cell migration inhibitor that targets the insulin-like growth factor 2 mRNA binding protein IGF2BP1 with a good affinity of Kd of 1.4?M. AVJ16 interferes with IGF2BP1 binding target mRNA to regulate gene expression and translation[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2775241-92-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144873.
AVL-292
AVL-292, also known as CC-292, is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, AVL-292 targets and covalently binds to BTK, thereby preventing its activity. Uses: Protein kinase inhibitors. Synonyms: CC-292; CC292; CC 292; AVL292; AVL 292; spebrutinib. Grade: 98%. CAS No. 1202757-89-8. Molecular formula: C22H22FN5O3. Mole weight: 423.44.
AVL-292 benzenesulfonate
AVL-292 benzenesulfonate is a covalent, highly selective, orally active small molecule inhibitor of Btk with IC50 value of 0.5 nM; >1400-fold selectivity over the other kinases assayed. Synonyms: Spebrutinib besylate; CC-292 besylate; AVL-292 benzenesulfonate; CC 292 besylate; AVL 292 benzenesulfonate; CC292 besylate; AVL292 benzenesulfonate. Grade: >98%. CAS No. 1360053-81-1. Molecular formula: C28H28FN5O6S. Mole weight: 581.62.
AVN-101 hydrochloride
AVN-101 is an antagonist of the serotonin (5-HT) receptor subtypes 5-HT7, 5-HT2C, 5-HT2A, and 5-HT6 (Kis = 0.153, 1.17, 1.56, and 2.04 nM, respectively). It is also an antagonist of α2A-, α2B-, α2C-, α1B-, α1A-, and α1D-adrenergic receptors (Kis = 0.41, 1.77, 3.55, 9.4, 18.9, and 30.2 nM, respectively), as well as histamine H1 and H2 (Kis = 0.58 and 89 nM, respectively), but not H3, receptors. It is a multi-target drug candidate for the treatment of CNS disorders. Synonyms: 2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride; AVN-101 HCl; 1H-Pyrido(4,3-b)indole, 2,3,4,5-tetrahydro-2,8-dimethyl-5-(2-phenylethyl)-, hydrochloride (1:1); 2,8-dimethyl-5-(2-phenylethyl)-1H,2H,3H,4H,5H-pyrido[4,3-b]indole hydrochloride; 2,3,4,5-tetrahydro-2,8-dimethyl-5-(2-phenylethyl)-1H-pyrido[4,3-b]indole, monohydrochloride. Grade: ≥95%. CAS No. 1061354-48-0. Molecular formula: C21H25ClN2. Mole weight: 340.90.
AVN-101 hydrochloride
AVN-101 hydrochloride is a potent, brain-penetrant and orally active 5-HT7 receptor antagonist ( K i of 153 pM), with slightly lesser potency toward 5-HT6 , 5-HT2A , and 5HT-2C receptors ( K i values of 2.04 nM, 1.56 ?nM, and 1.17? nM, respectively). AVN-101 hydrochloride also exhibits a rather high affinity toward histamine H1 ( K i of 0.58 nM) and adrenergic α2A , α2B , and α2C (Ki= 0.41-3.6 nM) receptors. AVN-101 hydrochloride can be studied in such diseases as general anxiety disorders, depression, schizophrenia, and multiple sclerosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1061354-48-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117046A.
AVN-211
This active molecular is a Selective 5-HT6 Receptor antagonist, for the treatment of Alzheimer's Disease under development by by Avineuro Pharmaceuticals. AVN-211 shows good anxiolytic efficacy, low toxicity ,no side effects in vivo, an appropriate pharmacokinetic profile and good stability. AVN-211 significantly delayed or partially halted the progressive decline in memory function associated with AD and this efficacy makes it an interesting drug candidate for the treatment of neurodegenerative and psychiatric disorders. In Jul 2015, Avineuro Pharmaceuticals completed a phase II trial in Schizophrenia in USA and planed a trial for Alzheimer's disease in USA. In Aug 2015, Phase-II development was ongoing for Schizophrenia in USA. Uses: Alzheimer's disease;schizophrenia. Synonyms: AVN-211; AVN 211; AVN211; CD-008-0173. 5,7-dimethyl-2-(methylthio)-3-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidine,CD-008-0173. Grade: 98%. CAS No. 1173103-84-8. Molecular formula: C15H15N3O2S2. Mole weight: 333.42.
AVN-492
AVN-492 is a novel potent and selective 5-HT6 receptor antagonist with Ki values of 91 pM and 170 nM for 5-HT6R and 5-HT2BR, respectively. Uses: Serotonin antagonists. Synonyms: AVN-492; AVN 492; AVN492. 3-(benzenesulfonyl)-2-N,6-N,6-N,5,7-pentamethylpyrazolo[1,5-a]pyrimidine-2,6-diamine. CAS No. 1220646-23-0. Molecular formula: C17H21N5O2S. Mole weight: 359.45.
AVN-944
AVN-944 (VX-944) is an orally available, synthetic small molecule with potential antineoplastic activity. AVN944 inhibits inosine monosphosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanosine triphosphate (GTP), a purine molecule required for DNA and RNA synthesis. AVN944 appears to have a selective effect on cancer cells in that deprivation of GTP in normal cells results in a temporary slowing of cell growth only. Synonyms: code name: AVN 944; AVN944; VX-944; VX 944; VX944. Grade: 0.98. CAS No. 297730-17-7. Molecular formula: C25H27N5O5. Mole weight: 477.51.
AVN-944
AVN-944 (VX-944) is an orally active, potent, selective, noncompetitive and specific inhibitor of IMPDH (inosine monophosphate dehydrogenase). AVN-944 is an essential rate-limiting enzyme in de novo guanine nucleotide synthesis. AVN-944 is also an inhibitor of arenavirus RNA synthesis, and blocks arenavirus infection. AVN-944 has broad anti-cancer activities, and can be used for multiple myeloma (MM) and acute myeloid leukemia (AML) research[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VX-944. CAS No. 297730-17-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13560.
Avobenzone
analytical standard. Group: Uv blockers.
Avobenzone
Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. Avobenzone is an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 70356-09-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0316.
Avobenzone
Avobenzone. Group: Biochemicals. Alternative Names: 1-[4-(1,1-Dimethylethyl)phenyl]-3-(4-methoxyphenyl)-1,3-propanedione; 1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione; Butyl methoxydibenzoyl methane . Grades: Highly Purified. CAS No. 70356-09-1. Pack Sizes: 25g, 50g, 100g, 250g, 500g. Molecular Formula: C20H22O3. US Biological Life Sciences.