A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Sedative; tranquilizer. Group: Biochemicals. Alternative Names: 1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone; 4'-Fluoro-4- [4- (2-pyridyl) -1-piperazinyl] butyrophenone; Fluoperidol; NSC 170976; R-1929; Stresnil; Suicalm. Grades: Highly Purified. CAS No. 1649-18-9. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Azaperone
Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. Synonyms: NSC 170976; NSC170976; NSC-170976. Grade: >98%. CAS No. 1649-18-9. Molecular formula: C19H22FN3O. Mole weight: 327.4.
Azaperone-d4
Azaperone-d4. Group: Biochemicals. Alternative Names: 1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone-d4; 4'-Fluoro-4- [4- (2-pyridyl) -1-piperazinyl] butyrophenone-d4; Fluoperidol-d4; NSC 170976-d4; R-1929-d4; Stresnil-d4; Suicalm-d4. Grades: Highly Purified. CAS No. 1173021-72-1. Pack Sizes: 5mg. Molecular Formula: C19H18D4FN3O, Molecular Weight: 331.42. US Biological Life Sciences.
Azaperone-[d4] is the labelled analogue of Azaperone, which is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects. It is mainly used as a tranquilizer in veterinary medicine. Synonyms: Azaperone-D4; 1-(4-Fluorophenyl-D4)-4-(4-pyridin-2-yl-piperazin-1-yl)-butan-1-one; 1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone-d4; 4'-Fluoro-4-[4-(2-pyridyl)-1-piperazinyl]butyrophenone-d4; Fluoperidol-d4; NSC 170976-d4; Stresnil-d4; Suicalm-d4. Grade: 95% by HPLC; 98% atom D. CAS No. 1173021-72-1. Molecular formula: C19H18D4FN3O. Mole weight: 331.42.
Azaphen
An antidepressant having effects on the autonomic nervous system; the drug is especially effective for mild and moderate depressions and a combination of Azaphen and Thymol is applicable for severa depressions. Azaphen improves sleep too. Synonyms: Azafen; Pipofezin hydrochloride; Pipofezine hydrochloride. Grade: >98%. CAS No. 24853-80-3. Molecular formula: C16H21Cl2N5O. Mole weight: 370.28.
Azaphen dihydrochloride monohydrate
Azaphen dihydrochloride monohydrate is a potent inhibitor of the reuptake of serotonin. It is a tricyclic antidepressant (TCA) approved in Russia for the treatment ofdepression. Synonyms: Azafen dihydrochloride monohydrate; Pipofezin dihydrochloride monohydrate; Azaphenonxazine dihydrochloride monohydrate. Grade: >98%. CAS No. 63302-99-8. Molecular formula: C16H23Cl2N5O2. Mole weight: 388.29.
Azapropazone
Azapropazone is a non-steroidal anti-inflammatory agent used in the treatment of rheumatoid arthritis. It also has uricosuric properties and has been used to treat gout. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: 1H-Pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-; 5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione; 3-Dimethylamino-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine; AHR 3018; Apazone; Cinnamin; Cinnopropazone; Mi 85; NSC 102824; Prolixan; Sinnamin. Grade: ≥95%. CAS No. 13539-59-8. Molecular formula: C16H20N4O2. Mole weight: 300.36.
Azapropazone dihydrate
Azapropazone dihydrate is a non-steroidal anti-inflammatory agent used in the treatment of rheumatoid arthritis. It also has uricosuric properties and has been used to treat gout. Synonyms: 1H-Pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-, hydrate (1:2); 1H-Pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-, dihydrate; 1,2-Dihydro-3-dimethylamino-7-methyl-1,2-(propylmalonyl)-1,2,4-benzotriazine dihydrate; 3-Dimethylamino-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine dihydrate; 5-(dimethylamino)-9-methyl-2-propyl-1H-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione dihydrate. Grade: ≥95%. CAS No. 22304-30-9. Molecular formula: C16H20N4O2.2H2O. Mole weight: 336.39.
Azapropazone dihydrate
Azapropazone dihydrate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1,2-Dihydro-3-dimethylamino-7-methyl-1,2-(propylmalonyl)-1,2,4-benzotriazine dihydrate; Prolixana; Azapropazon dihydrat; Apazone dihydrate; Tolyprin; Azapropazon dihydrat [German]; Azapropazone dihydrate; 1H-Pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione,5-(dimethylamino)-9-methyl-2-propyl-,dihydrate; 3-Dimethylamino-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine dihydrate. CAS No. 22304-30-9. Molecular formula: C16H24N4O4. Mole weight: 336.39. Purity: 0.96. IUPACName: 5-(dimethylamino)-9-methyl-2-propylpyrazolo[1,2-a][1,2,4]benzotriazine-1,3-dione;dihydrate. Canonical SMILES: CCCC1C(=O)N2C3=C(C=CC(=C3)C)N=C(N2C1=O)N(C)C.O.O. Density: 1.29g/cm³. Product ID: ACM22304309. Alfa Chemistry ISO 9001:2015 Certified.
Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine) is a potent orotidine monophosphate decarboxylase (OMPD) inhibitor. Azaribine is an antiviral inhibitor of several RNA viruses and inhibits viral genome replication and gene transcription. Azaribine shows broad-spectrum antiviral activity ( EC 50 =3.80?nM-1.73?μM against influenza A and B viruses; EC 50 =1.62 μM against ZIKV Paraiba). Azaribine, a triacetate salt of Azauridine, has the potential for psoriasis research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2',3',5'-Tri-O-acetyl-6-azauridine. CAS No. 2169-64-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-B1537.
Azaserine
It is produced by the strain of Streptomyces fragilis 04926. Azaserine is a naturally occurring serine derivative diazo compound with antineoplastic properties, Azaserine functions as a purine antagonist and glutamine analogue (glutamine amidotransferase inhibitor) that competitively inhibits pathways in which glutamine is metabolized. Uses: Antibiotics, antifungal; antibiotics, antineoplastic; antimetabolites; antimetabolites, antineoplastic; carcinogens; immunosuppressive agents. Synonyms: diazoacetate (ester) L-Serine; diazoacetylserine; serine diazoacetate. Grade: 98%. CAS No. 115-02-6. Molecular formula: C5H7N3O4. Mole weight: 173.13.
Azaserine
Azazerine (CI-337) is a competitive inhibitor of glutamine amidotransferase. Azaserine is an antibiotic , it shows antibacterial activities. Azazerine shows anti-tumor activities and it may also act as a tumor inducer. Azazerine can be used for the research of cancer and infection [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CI-337; O-Diazoacetyl-L-serine; P-165. CAS No. 115-02-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0919.
Azasetron-13C,D3 Hydrochloride
A 5-HT3 receptor antagonist. Used as an antiemetic. Group: Biochemicals. Alternative Names: N-1-Azabicyclo[2.2.2]-oct-3-yl-6-chloro-3,4-dihydro-4-(methyl-13C,d3)-3-oxo-2H-1,4-benzoxazine-8-carboxamide Hydrochloride. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences.
Worldwide
Azasetron-[d3] Hydrochloride
Azasetron-[d3] Hydrochloride is the labelled analogue of Azasetron Hydrochloride, which is a 5-HT3 receptor antagonist and used as an antiemetic. Synonyms: Azasetron-d3 Hydrochloride; N-1-Azabicyclo[2.2.2]-oct-3-yl-6-chloro-3,4-dihydro-4-(methyl-d3)-3-oxo-2H-1,4-benzoxazine-8-carboxamide Hydrochloride; Serotone-d3; Nazasetron-d3; Y-25130-d3 hydrochloride; 6-chloro-4-methyl-3-oxo-N-(quinuclidin-3-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide-d3 hydrochloride. Grade: 98%; ≥99% atom D. CAS No. 1216505-58-6. Molecular formula: C17H18D3Cl2N3O3. Mole weight: 389.29.
A 5-HT3 receptor antagonist. Used as an antiemetic. Group: Biochemicals. Alternative Names: N-1-Azabicyclo[2.2.2]-oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-8-carboxamide-d3, Hydrochloride. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Azasetron hydrochloride
Azasetron (Y-25130) hydrochloride, a benzamide derivative, is a potent and selective 5-HT3 receptor antagonist. Azasetron is used in the study for Chemotherapy-induced nausea and vomiting (CINV) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Y-25130 hydrochloride. CAS No. 123040-16-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0068.
Azasetron hydrochloride
Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy. Uses: Antiemetics. Synonyms: Azasetron hydrochloride; Y 25130; Y-25130; Y25130. Y-25130 HCl. Grade: >98%. CAS No. 123040-16-4. Molecular formula: C17H20ClN3O3.HCl. Mole weight: 386.27.
Azasetron hydrochloride
Azasetron hydrochloride. Group: Biochemicals. Alternative Names: N-1-Azabicyclo[2.2.2]-oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-8-carboxamide hydrochloride. Grades: Highly Purified. CAS No. 123040-69-7. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C17H21Cl2N3O3. US Biological Life Sciences.
A 5-HT3 receptor antagonist. Used as an antiemetic. Group: Biochemicals. Alternative Names: N-1-Azabicyclo[2.2.2]-oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-8-carboxamide, Hydrochloride. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Azasetron Impurity 2
Azasetron Impurity 2. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxylic acid. CAS No. 123040-79-9. Molecular formula: C10H8ClNO4. Mole weight: 241.63. Catalog: APB123040799.
Azatadine
Azatadine is a new antihistamine acts as histamine for histamine H1- receptor inhibitor ( IC50 = 6.5 nM and 10 nM, respectively). Uses: Antihistaminic. Synonyms: 6,11-Dihydro-11-(1-methyl-4-piperidylidene)-5H-benzo[5,6]cyclohepta-[1,2-b]pyridine; 2-(1-methylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.0³,?]pentadeca-1(15),3(8),4,6,11,13-hexaene. Grade: ≥98%. CAS No. 3964-81-6. Molecular formula: C20H22N2. Mole weight: 290.40.
Azatadine dimaleate
Azatadine dimaleate. Group: Biochemicals. Alternative Names: 6, 11-Dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5, 6]cyclohepta[1, 2-b]pyridine; Azatadine Dimaleate. Grades: Highly Purified. CAS No. 3964-81-6,3978-86-7. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C20H22N2. US Biological Life Sciences.
Worldwide
Azatadine Dimaleate
Azatadine is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively. Uses: Histamine h1 antagonists. Synonyms: SCH10649; SCH 10649; SCH-10649. Grade: >98%. CAS No. 3978-86-7. Molecular formula: C20H22N2.2C4H4O4. Mole weight: 522.55.
Azatadine Dimaleate.
Antihistaminic. Group: Biochemicals. Alternative Names: 6, 11-Dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5, 6]cyclohepta[1, 2-b]pyridine (2Z)-2-Butenedioate; 5- (4'-N-methyl piperidyl ide ne )-4-azo-10: 11-di hydrodibenzocyclohe ptene Dimaleate; Atoramin; Azatadine Maleate; Bonamid; Idulian; Optimine; Sch 10649; Trinalin; Zadine. Grades: Highly Purified. CAS No. 3978-86-7. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
Azatadine maleate
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis [1] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BW 57-322. CAS No. 446-86-6. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-B0256.
Azathioprine
Azathioprine. Group: Biochemicals. Grades: Purified. CAS No. 446-86-6. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
Azathioprine
Azathioprine is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases. Uses: Antimetabolites. Synonyms: azathioprine; 446-86-6; Imuran; Azothioprine; Azathioprin; Azamun; Azanin; Azatioprin; Azasan; Ccucol; Imurek; Imurel; Muran; Azathiopurine; Rorasul; Azathioprinum; BW 57-322; NSC-39084; BW-57-322; Azatioprina; 6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine; NCI-C03474; NSC 39084; Methylnitroimidazolylmercaptopurine; 6-(1-Methyl-p-nitro-5-imidazolyl)-thiopurine; Azathioprinum [INN-Latin]; Azatioprina [INN-Spanish]; CCRIS 62; Imuran (TN); 6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine; 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-7H-purine; 6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine; HSDB 7084; 6-((1-Methyl-4-nitroimidazol-5-yl)thio)purine; Purine, 6-(1-methyl-4-nitro-5-imidazolylthio)-; 1H-Purine, 6-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)-. Grade: >98%. CAS No. 446-86-6. Molecular formula: C9H7N7O2S. Mole weight: 277.26.
Azathioprine-13C4
Labeled Azathioprine. An immunosuppressive antimetabolite. Also active as disease modifying antirheumatic drug (DMARD). Group: Biochemicals. Alternative Names: 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine-13C4; BW-57-322-13C4; NSC-39084-13C4; Azanin-13C4; Imuran-13C4; Imurek-13C4; Imurel-13C4; Zytrim-13C4. Grades: Highly Purified. CAS No. 1346600-71-2. Pack Sizes: 500ug. US Biological Life Sciences.
Worldwide
Azathioprine-[13C4]
Azathioprine-[13C4] is the labelled analogue of Azathioprine. Azathioprine is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases. Synonyms: Azathioprine-13C4; 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine-13C4; BW-57-322-13C4; NSC-39084-13C4; Azanin-13C4; Imuran-13C4; Imurek-13C4; Imurel-13C4; Zytrim-13C4. Grade: ≥96%; ≥98% atom 13C. CAS No. 1346600-71-2. Molecular formula: C5[13C]4H7N7O2S. Mole weight: 281.23.
An immunosuppressive antimetabolite. Also active as disease modifying antirheumatic drug (DMARD). Group: Biochemicals. Alternative Names: 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine, BW-57-322, NSC-39084,Azanin, Imuran, Imurek, Imurel, Zytrim. Grades: Highly Purified. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
Azathioprine EP Impurity D
Azathioprine EP Impurity D is a metabolite of Azathioprine. Synonyms: 1-Methyl-4-nitro-5-thioimidazole; 1-Methyl-4-nitro-1H-imidazole-5-thiol; 5-Mercapto-1-methyl-4-nitroimidazole. Grade: > 95%. CAS No. 6339-54-4. Molecular formula: C4H5N3O2S. Mole weight: 159.17.
Azathioprine EP Impurity E Sodium Salt
Azathioprine EP Impurity E Sodium Salt is a degradation product of Azathioprine. Synonyms: 5-Hydroxy-1-methyl-4-nitroimidazole Sodium Salt; 1-Methyl-4-nitro-1H-imidazol-5-ol Sodium Salt. Grade: > 95%. CAS No. 35681-68-6. Molecular formula: C4H4N3O3Na. Mole weight: 165.08.
Azathioprine Impurity 16
Azathioprine Impurity 16. Uses: For analytical and research use. Group: Impurity standards. CAS No. 152529-79-8. Molecular formula: C14H14N4O5S. Mole weight: 350.35. Catalog: APB152529798.
Azathioprine Impurity C
Azathioprine Impurity C is an impurity of 6-Mercaptopurine, which is an immunosuppressive drug used to treat leukemia. Synonyms: 6-Mercaptopurine Disulfide; 6,6'-Dithiodi-9H-purine; 6,6'-Dithiodi-purine; Bis(6-purinyl) disulfide; 1,2-Di(9H-purin-6-yl)disulfane; NSC 166569; NSC 77640. Grade: > 95%. CAS No. 49808-20-0. Molecular formula: C10H6N8S2. Mole weight: 302.34.
Azathioprine Related Compound A
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Azathioprine Related Compound G
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
AzBTS
Spectrophotometric reagent for free chlorine. Group: Uv/visible (uv/vis) spectroscopy. Alternative Names: 2,2'-Azinobis(3-ethylbenzothiazoline-6-sulfonic Acid Ammonium Salt).
AZD0095
AZD0095 is a selective and orally active MCT4 inhibitor (IC50: 1.3 nM). AZD0095 effectively inhibits the tumor growth in NCI-H358 xenograft in combination with Cediranib (HY-10205)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2750001-23-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-148517.
AZD0156
AZD0156 is an orally active, potent and selective ataxia telangiectasia mutated (ATM) kinase inhibitor, used for cancer treatment. AZD0156 prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducing tumor cell apoptosis, and leading to cell death in ATM-overexpressing tumor cells. Uses: Protein kinase inhibitors. Synonyms: 8-[6-[3-(dimethylamino)propoxy]-3-pyridyl]-3-methyl-1-tetrahydropyran-4-yl-imidazo[4,5-c]quinolin-2-one; AZD0156; AZD-0156; AZD 0156. CAS No. 1821428-35-6. Molecular formula: C26H31N5O3. Mole weight: 461.56.
AZD0156
AZD0156 is a potent, selective and orally active ATM inhibitor with an IC 50 of 0.58 nM. AZD0156 inhibits the ATM -mediated signaling, prevents DNA damage checkpoint activation, disrupts DNA damage repair, and induces tumor cell apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1821428-35-6. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100016.
AZD-0284
AZD-0284 is a reverse agonist of the nuclear receptor (RORγ). AZD-0284 has the potential for the treatment of plaque psoriasis vulgaris and respiratory tract disorders. Synonyms: AZD0284; AZD 0284. CAS No. 2101291-07-8. Molecular formula: C21H18F6N2O5S. Mole weight: 524.43.
AZD 0328
AZD 0328 is a potent α7 NNR/5HT3 receptor agonist. AZD0328 led to a significant increase in cortical dopamine release in awake rodents and improved both conditioned response learning and memory retention in an object recognition task. Synonyms: (3R)-spiro[1-azabicyclo[2.2.2]octane-3,2'-3H-furo[2,3-b]pyridine]; AZD 0328; AZD-0328; AZD0328; UNII-2B218X5QIY; spiro(1-azabicyclo(2.2.2)octane-3,2'(3H)-furo(2,3-b)pyridine). Grade: >98%. CAS No. 220099-91-2. Molecular formula: C13H16N2O. Mole weight: 216.28.
AZD0364
AZD-0364 is a potent and selective ERK2 inhibitor, which has an IC50 value of 0.6 nM. AZD-0364 is measured in the A375 phospho-p90RSK assays with IC50s of 5.7 nM. AZD-0364 can inhibit the growth of a panel of cancer cell lines. The combination of Selumetinib and AZD-0364 ethanesulfonic acid results in a reduction in tumor growth. Synonyms: AZD-0364; AZD 0364; tizaterkib. Grade: ≥98%. CAS No. 2097416-76-5. Molecular formula: C24H24F2N8O2. Mole weight: 494.50.
AZD0424
AZD0424 is an orally bioavailable small molecule tyrosine kinase inhibitor. It targets both Abl and Src kinases with potential antineoplastic activity. It selectively inhibits both Src and Abl kinase activity and may result in the inhibition of tumor growth in susceptible tumor cells. Uses: Azd0424 has the inhibition of tumor growth in tumor cells. Synonyms: AZD 0424; AZD-0424; 1-(4-(2-((4-((6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino)-5-isopropoxyquinazolin-7-yl)oxy)ethyl)piperazin-1-yl)ethan-1-one; 7-(2-(4-Acetylpiperazin-1-yl)ethoxy)-4-(5-chloro-2,3-methylenedioxypyridin-4-ylamino)-5-isopropoxyquinazoline. Grade: 98%. CAS No. 692054-06-1. Molecular formula: C25H29ClN6O5. Mole weight: 528.99.
AZD0780
PCSK9-IN-12 is a heteroaryl compound. PCSK9-IN-12 has bind affinity for PCSK9 with a K d value of ?200 nM. PCSK9-IN-12 can be used for the research of cholesterol metabolism [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PCSK9-IN-12. CAS No. 2455427-91-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148673.
AZD-0837
AZD0837 is an oral direct thrombin inhibitor currently in clinical development for the prevention of stroke and systemic embolic events in patients with atrial fibrillation. Uses: Potassium channel antagonist. Synonyms: AZD0837; AZD-0837; AZD 0837; Atecegatran metoxil; Atecegatran fexenetil.1-((2R)-(3-chloro-5- (difluoromethoxy)phenyl)hydroxyacetyl)-N-((4-(imino(methoxyamino)methyl)phenyl)methyl)-, (2S)-2-Azetidinecarboxamide; (S)-1-((R)-2-(3-chloro-5-(difluoromethoxy)phenyl)-2-hydroxyacetyl)-N-(4-(N-methoxycarbamimidoyl)benzyl)azetidine-2-carboxamide. Grade: ≥95%. CAS No. 433937-93-0. Molecular formula: C22H23ClF2N4O5. Mole weight: 496.89.
AZD1080 is a brain-permeable GSK3 inhibitor with Ki values of 6.9 nM and 31 nM for GSK3α and GSK3β, respectively. Study showed that AZD1080 inhibited tau phosphorylation in cells. It also suppresses ovarian cancer cell proliferation, invasion, migration, and lamellipodia formation, and induces G1 arrest. Synonyms: AZD-1080; 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile. Grade: >98%. CAS No. 612487-72-6. Molecular formula: C19H18N4O2. Mole weight: 334.37.
AZD1080
AZD1080 is a potent and selective GSK3 inhibitor. AZD1080 inhibits recombinant human GSK3? and GSK3? with pKi (IC50) of 8.2 (6.9 nM) and 7.5 (31 nM), respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 612487-72-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13862.
Barasertib is a potent and highly selective inhibitor of AURKB with IC50 of 0.37 nM, acting via preventing the transfer of the phosphate group from the ATP molecule to AURKB substrates. The present study demonstrated for the first time, that AURKB inhibition interferes with early regeneration of SGs. Barasertib has been demonstrated that it is 3,700-fold greater selectivity than Aurora A. Synonyms: INH 34; AZD1152-HQPA; AZD2811. Grade: ≥98%. CAS No. 722544-51-6. Molecular formula: C26H30FN7O3. Mole weight: 507.56.
AZD1152, TFA Salt
An Aurora kinase inhibitor, used to treat patients with advanced solid tumors. Group: Biochemicals. Alternative Names: 3-[[7-[3-[Ethyl[2- (phosphonooxy) ethyl]amino]propoxy]-4-quinazolinyl]amino]-N- (3-fluorophenyl) -1H-pyrazole-5-acetamide Trifluoroacetic Acid Salt; Barasertib Trifluoroacetic Acid Salt; AZD-1152 Trifluoroacetic Acid Salt. Grades: Highly Purified. CAS No. 957881-03-7. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C??H??FN?O?P; x(C ?HF?O?), Molecular Weight: 587.54. US Biological Life Sciences.
Worldwide
AZD1208
AZD1208 is an orally bioavailable, highly selective PIM kinases inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1204144-28-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15604.
AZD-1208
AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. AZD1208 inhibits the activities of PIM1, PIM2 and PIM3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition. Synonyms: AZD1208; AZD 1208. Grade: 0.98. CAS No. 1204144-28-4. Molecular formula: C21H21N3O2S. Mole weight: 379.478.
AZD1208 hydrochloride
AZD1208 (hydrochloride) is an orally bioavailable and highly selective PIM kinases inhibitor. CAS No. 1621866-96-3. Molecular formula: C21H22ClN3O2S. Mole weight: 415.94.
AZD1283
AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithrombotic ED50 values of 3.0 and 10 μg/kg/min, respectively. The doses that induced a larger than 3-fold increase in bleeding time were 33 and 100 μg/kg/min for 3 and 13, respectively. Thus, the therapeutic index (TI) was ≥10 for both compounds. On the basis of these data, compound 3 was progressed into human clinical trials as candidate drug AZD1283. Synonyms: AZD 1283; AZD-1283. Grade: 0.98. CAS No. 919351-41-0. Molecular formula: C23H26N4O5S. Mole weight: 470.544.
AZD1390 is a first-in-class, orally available and CNS penetrant ATM inhibitor with an IC50 of 0.78 nM in cells and >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases. It can be used to cross the blood-brain barrier suitable for the treatment of intracranial malignancies. Synonyms: AZD-1390; AZD 1390. Grade: ≥98%. CAS No. 2089288-03-7. Molecular formula: C27H32FN5O2. Mole weight: 477.57.
AZD1390
AZD1390 is a potent, highly selective, orally bioavailable, brain-penetrant ATM inhibitor with an IC 50 of 0.78 nM in cell [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2089288-03-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109566.
AZD1480
AZD1480 is a novel ATP-competitive inhibitor of JAK1 and JAK2 with IC50 of 1.3nM and 0.26nM, respectively. Group: Biochemicals. Alternative Names: (S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. US Biological Life Sciences.
AZD1480 is an orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity. AZD1480 inhibits JAK2 activation, leading to the inhibition of the JAK/STAT (signal transducer and activator of transcription) signaling including activation of STAT3. Synonyms: AZD1480; AZD-1480; AZD 1480. Grade: 0.98. CAS No. 935666-88-9. Molecular formula: C14H14ClFN8. Mole weight: 348.77.
AZD-1480
AZD-1480 is an ATP-competitive inhibitor of JAK1 and JAK2 with IC50s of 1.3 nM and <0.4?nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 935666-88-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10193.