A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Aldehydo-D-glucose Phthalazin-1-ylhydrazone is a carbohydrate derivative of hydrazinophthalazine with anti-inflammatory activity. Synonyms: 1-(2-D-Glucopyranosylhydrazino)phthalazine; 1-Deoxy-1-[2-(1-phthalazinyl)hydrazinyl]-D-glucopyranose; D-Glucopyranose, 1-deoxy-1-[2-(1-phthalazinyl)hydrazinyl]-; Phthalazine, 1-(2-D-glucopyranosylhydrazino)-. Grade: 95%. CAS No. 881180-23-0. Molecular formula: C14H18N4O5. Mole weight: 322.32.
Aldenafil impurity 1
Aldenafil impurity 1. Uses: For analytical and research use. CAS No. 17344-99-9. Molecular formula: C5H11NO2. Mole weight: 117.15. Catalog: APB17344999.
Aldgamycin F
It is produced by the strain of Streptomyces lavendulae and Str. avidinii. The anti-gram-positive bacteria activity of G was stronger than that of F, and the anti-Staphylococcus aureus activity was similar to that of xiramycin. CAS No. 55141-41-8. Molecular formula: C37H56O16. Mole weight: 756.83.
Aldgamycin G
It is produced by the strain of Streptomyces lavendulae and Str. avidinii. The anti-gram-positive bacteria activity of G was stronger than that of F, and the anti-Staphylococcus aureus activity was similar to that of xiramycin. Synonyms: 8-Deoxyaldgamycin F; Aldgamycin G; Aldgamycin F, 8-deoxy-; LS-16283; (6Z,14Z)-2-(((5-hydroxy-3,4-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)-9-((6-hydroxy-4,9-dimethyl-2-oxo-1,3,8-trioxaspiro[4.5]decan-7-yl)oxy)-3,8,10,12-tetramethyl-4,17-dioxabicyclo[14.1.0]heptadeca-6,14-diene-5,13-dione; 1,3,8-Trioxaspiro[4.5]decane, aldgamycin F deriv.; 4,17-Dioxabicyclo[14.1.0]heptadecane, aldgamycin F deriv. Grade: 95%. CAS No. 107745-56-2. Molecular formula: C37H56O15. Mole weight: 740.83.
ALDH
ALDH (Aldehyde dehydrogenase (NAD(P))) catalyzes the oxidation of aldehydes into their corresponding carboxylic acids with the concomitant reduction of the cofactor NAD(P) into NAD(P)H, is often used in biochemical studies. The ALDHs are one of many enzyme systems the body utilizes to alleviate aldehyde stress[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Aldehyde dehydrogenase (NAD(P)). CAS No. 9028-88-0. Pack Sizes: 25 U. Product ID: HY-P2947.
ALDH1A1-IN-2
ALDH1A1-IN-2 (compound 297) is a potent inhibitor of aldehyde dehydrogenase 1a1 (aldh1a1). Aldehyde dehydrogenases (ALDH) constitute a family of enzymes that play a critical role in oxidizing various cytotoxic xenogenic and biogenic aldehydes. ALDH1A1-IN-2 has the potential for the research of cancer, inflammation, or obesity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2231081-18-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126003.
ALDH1A3-IN-1
ALDH1A3-IN-1 (Compound 14) is a potent ALDH1A3 inhibitor, with an IC50 of 0.63 μM and a Ki of 0.46 μM. ALDH1A3-IN-1 can be studied in prostate cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1695970-90-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144667.
ALDH2 activator 1
ALDH2 activator 1 (Compound Z17) is an allosteric aldehyde dehydrogenase 2 (ALDH2) agonist. ALDH2 activator 1 enhances cardiac function and reduces myocardial necrosis in a mouse model of myocardial ischemia-reperfusion. ALDH2 activator 1 is promising for research of cardiovascular diseases such as myocardial infarction (MI)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2988020-77-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-176716.
ALDH3A1-IN-1
ALDH3A1-IN-1 (Compound 18) is a potent inhibitor of ALDH3A1 with an IC50 of 1.61 μM. ALDH3A1-IN-1 is more potent than DEAB against patient-derived primary prostate tumor epithelial cells, as single agents or in combination research with docetaxel[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1039855-56-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144670.
ALDH3A1-IN-3
ALDH3A1-IN-3 (CB29) is a selective inhibitor of ALDH3A1, with a Ki value of 4.7 μM and an IC50 value of 16 μM. ALDH3A1-IN-3 has no inhibitory potential on the in vitro activity of ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, or ALDH2. ALDH3A1-IN-3 can be used in cellular oxidation and cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 315239-63-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125085.
Aldicarb
Aldicarb. Group: Biochemicals. Alternative Names: O- (Methylcarbamoyl) -2-methyl-2- (methylthio) propionaldehyd-oxime. Grades: Highly Purified. CAS No. 116-06-3. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C7H14N2O2S. US Biological Life Sciences.
Worldwide
Aldicarb sulfone
Aldicarb Sulfone is an analog of Aldicarb detected in agricultural products as pesticide residue. Synonyms: Temik sulfone. Grade: >98%. CAS No. 1646-88-4. Molecular formula: C7H14N2O4S. Mole weight: 222.26.
Aldicarb-sulfoxide
Aldicarb-sulfoxide. Alternative Names: 2-methyl-2-(methylsulfinyl)propanalo-((methylamino)carbonyl)oxime;2-methyl-2-(methylsulfinyl)-propanao-((methylamino)carbonyl)oxime;2-methyl-2-(methylsulfinyl)propionaldehydeo-(methylcarbamoyl)oxime;2-methyl-2-(methylsulfinyl)-propionaldehydo-(methylcarbamoyl)oxime;temiksulfoxide;2-METHYL-2-(METHYLSULFOXO)PROPANAL-O-[(METHYLAMINO)CARBONYL]OXIME;ALDICARB-SULFOXIDE;ALDICARB SULPHOXIDE. CAS No. 1646-87-3. Product ID: ACM1646873. Molecular formula: C7H14N2O3S. Mole weight: 206.26. Alfa Chemistry - ISO 9001:32057 Certified.
The enzyme from Streptomyces sp. IKD472 and from Streptomyces coelicolor is a monomeric oxidase containing one molecule of FAD per molecule of protein. While xylitol (five carbons) and sorbitol (6 carbons) are the preferred substrates, other alditols, including L-threitol (four carbons), D-arabitol (five carbons), D-galactitol (six carbons) and D-mannitol (six carbons) can also act as substrates, but more slowly. Belongs in the vanillyl-alcohol-oxidase family of enzymes. Group: Enzymes. Synonyms: xylitol oxidase; xylitol:oxygen oxidoreductase; AldO. Enzyme Commission Number: EC 1.1.3.41. CAS No. 177322-52-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0414; alditol oxidase; EC 1.1.3.41; 177322-52-0; xylitol oxidase; xylitol:oxygen oxidoreductase; AldO. Cat No: EXWM-0414.
Aldolase
enantioselectively catalyze y carbon-carbon bond formations. Group: Enzymes. Synonyms: Aldolase; DERA. Form: 1. Enzyme Powder: 8 items*50mg / item, or other quantity2. Screening Kit: 8 items*1mg / item. Aldolase; DERA; Screening Kit; library of enzyme; enzyme library. Cat No: ENLC-009.
Aldolase A from Human, Recombinant
Fructose bisphosphate aldolase A, also known as Aldolase A is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. It is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Deficiency has been associated with myopathy and hemolytic anemia. Recombinant human Aldolase A, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Group: Enzymes. Synonyms: Fructose bisphosphate Aldolase A; ALDOA; ALDA; GSD12. Enzyme Commission Number: EC 4.1.2.13. Purity: > 95% by SDS-PAGE. Aldolase. Mole weight: 41.5 kDa (384 aa, 1-364 aa + His Tag), confirmed by MALDI-TOF. Activity: > 1.5 units/mg. Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. Form: Liquid. Source: E. coli. Species: Human. Fructose bisphosphate Aldolase A; ALDOA; ALDA; GSD12; Aldolase A; Aldolase. Cat No: NATE-1663.
Aldometanib
Aldometanib is an active aldolase inhibitor. It prevents FBP from binding to v-ATPase-associated aldolase and activates lysosomal AMPK. Aldometanib can be used for the research of metabolic homeostasis. Grade: >98.0%. CAS No. 2904601-67-6. Molecular formula: C27H43Cl2IN2. Mole weight: 593.46.
Aldometanib
Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LXY-05-029. CAS No. 2904601-67-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-148189.
aldos-2-ulose dehydratase
This enzyme catalyses two of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-anhydro-D-fructose. Aldose-2-uloses such as 2-dehydroglucose can also act as substrates, but more slowly. This is a bifunctional enzyme that acts as both a lyase and as an isomerase. Differs from EC 4.2.1.111, which can carry out only reaction (1a), is inhibited by its product and requires metal ions for activity. Group: Enzymes. Synonyms: pyranosone dehydratase; AUDH; 1,5-anhydro-D-fructose dehydratase (microthecin-forming). Enzyme Commission Number: EC 4.2.1.110. CAS No. 101920-80-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4950; aldos-2-ulose dehydratase; EC 4.2.1.110; 101920-80-3; pyranosone dehydratase; AUDH; 1,5-anhydro-D-fructose dehydratase (microthecin-forming). Cat No: EXWM-4950.
aldose 1-dehydrogenase (NAD+)
Acts on D-glucose, 2-deoxy- and 6-deoxy-D-glucose, D-galactose, 6-deoxy-D-galactose, 2-deoxy-L-arabinose and D-xylose. Group: Enzymes. Synonyms: aldose dehydrogenase; D-aldohexose dehydrogenase; aldose 1-dehydrogenase. Enzyme Commission Number: EC 1.1.1.121. CAS No. 9076-61-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0025; aldose 1-dehydrogenase (NAD+); EC 1.1.1.121; 9076-61-3; aldose dehydrogenase; D-aldohexose dehydrogenase; aldose 1-dehydrogenase. Cat No: EXWM-0025.
aldose 1-dehydrogenase [NAD(P)+]
The enzyme from the archaeon Sulfolobus solfataricus shows broad specificity towards aldoses (D-glucose, D-galactose, D-xylose, L-arabinose, 6-deoxy-D-glucose, D-fucose) and can utilize NAD+ and NADP+ with similar catalytic efficiency. It is involved in aldose catabolism via the branched variant of the Entner-Doudoroff pathway. Group: Enzymes. Enzyme Commission Number: EC 1.1.1.359. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0275; aldose 1-dehydrogenase [NAD(P)+]; EC 1.1.1.359. Cat No: EXWM-0275.
aldose 1-epimerase
Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose. This enzyme catalyses the first step in galactose metabolism by converting β-D-galactose into α-D-galactose, which is the substrate for EC 2.7.1.6, galactokinase. Group: Enzymes. Synonyms: mutarotase; aldose mutarotase; galactose mutarotase; galactose 1-epimerase; D-galactose 1-epimerase. Enzyme Commission Number: EC 5.1.3.3. CAS No. 9031-76-9. Mutarotase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5416; aldose 1-epimerase; EC 5.1.3.3; 9031-76-9; mutarotase; aldose mutarotase; galactose mutarotase; galactose 1-epimerase; D-galactose 1-epimerase. Cat No: EXWM-5416.
aldose-1-phosphate adenylyltransferase
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). Group: Enzymes. Synonyms: sugar-1-phosphate adenylyltransferase; ADPaldose phosphorylase; adenosine diphosphosugar phosphorylase; ADP sugar phosphorylase; adenosine diphosphate glucose:orthophosphate adenylyltransferase; ADP:aldose-1-phosphate adenylyltransferase. Enzyme Commission Number: EC 2.7.7.36. CAS No. 37278-27-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3247; aldose-1-phosphate adenylyltransferase; EC 2.7.7.36; 37278-27-6; sugar-1-phosphate adenylyltransferase; ADPaldose phosphorylase; adenosine diphosphosugar phosphorylase; ADP sugar phosphorylase; adenosine diphosphate glucose:orthophosphate adenylyltransferase; ADP:aldose-1-phosphate adenylyltransferase. Cat No: EXWM-3247.
aldose-1-phosphate nucleotidyltransferase
The enzyme works on a variety of α-D-aldose 1-phosphates and β-L-aldose 1-phosphates (which have the same anomeric configuration as the former; see 2-Carb-6.2). Group: Enzymes. Synonyms: sugar-1-phosphate nucleotidyltransferase; NDPaldose phosphorylase; glucose 1-phosphate inosityltransferase; NDP sugar phosphorylase; nucleoside diphosphosugar phosphorylase; sugar phosphate nucleotidyltransferase; nucleoside diphosphate sugar:orthophosphate nucleotidyltransferase; sugar nucleotide phosphorylase; NDP:aldose-1-phosphate nucleotidyltransferase. Enzyme Commission Number: EC 2.7.7.37. CAS No. 9033-61-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3248; aldose-1-phosphate nucleotidyltransferase; EC 2.7.7.37; 9033-61-8; sugar-1-phosphate nucleotidyltransferase; NDPaldose phosphorylase; glucose 1-phosphate inosityltransferase; NDP sugar phosphorylase; nucleoside diphosphosugar phosphorylase; sugar phosphate nucleotidyltransferase; nucleoside diphosphate sugar:orthophosphate nucleotidyltransferase; sugar nucleotide phosphorylase; NDP:aldose-1-phosphate nucleotidyltransferase. Cat No: EXWM-3248.
aldose-6-phosphate reductase (NADPH)
In the reverse reaction, acts also on D-galactose 6-phosphate and, more slowly, on D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate. Group: Enzymes. Synonyms: aldose 6-phosphate reductase; NADP-dependent aldose 6-phosphate reductase; A6PR; aldose-6-P reductase; aldose-6-phosphate reductase; alditol 6-phosphate:NADP 1-oxidoreductase; aldose-6-phosphate reductase (NADPH2). Enzyme Commission Number: EC 1.1.1.200. CAS No. 76901-04-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0105; aldose-6-phosphate reductase (NADPH); EC 1.1.1.200; 76901-04-7; aldose 6-phosphate reductase; NADP-dependent aldose 6-phosphate reductase; A6PR; aldose-6-P reductase; aldose-6-phosphate reductase; alditol 6-phosphate:NADP 1-oxidoreductase; aldose-6-phosphate reductase (NADPH2). Cat No: EXWM-0105.
aldose β-D-fructosyltransferase
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. Group: Enzymes. Enzyme Commission Number: EC 2.4.1.162. CAS No. 9031-67-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2387; aldose β-D-fructosyltransferase; EC 2.4.1.162; 9031-67-8. Cat No: EXWM-2387.
Aldose reductase from Human, Recombinant
In enzymology, aldose reductase (or aldehyde reductase) (EC 1.1.1.21) is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. It is primarily known for catalyzing the reduction of glucose to sorbitol, the first step in polyol pathway of glucose metabolism. Group: Enzymes. Synonyms: Aldehyde reductase; Aldo-keto reductase family 1 member B1. Enzyme Commission Number: EC 1.1.1.21. CAS No. 9028-31-3. Aldose reductase. Mole weight: 35853.4 Da. Source: Human. Aldehyde reductase; Aldo-keto reductase family 1 member B1; EC 1.1.1.21; Aldose reductase. Cat No: NATE-1198.
Aldose reductase-IN-1
Aldose reductase-IN-1, an aldose reductase inhibitor, could have potential biological usage in the study of breast cancer. IC50: 28.9 pM. Uses: Aldose reductase-in-1 is an aldose reductase inhibitor that could have potential biological usage in the study of breast cancer. Synonyms: Aldose reductase-IN-1; SCHEMBL359604; CS-5128; HY-18967; AT-001; CS 5128; HY 18967; AT 001; CS5128; HY18967; AT001. Grade: 98%. CAS No. 1355612-71-3. Molecular formula: C17H10F3N5O3S. Mole weight: 421.35.
Aldosterone
An adrenocortical steroid which exerts regulatory influence on metabolism of electrolytes and water. Biologically active aldosterone isomer; a mineralocorticoid produced by the adrenal cortex that induces urinary excretion of K+ and renal reabsorptioon of Na+. Exists as an equilibrium mixture of the aldehyde and the hemiacetal. Group: Biochemicals. Alternative Names: 4-Pregnen-11β, 21-Diol-3, 18, 20-Trione; (11 β)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al; 11 β,21-Dihydroxypregn-4-ene-3,18,20-trione; 18-Formyl-11 β,21-dihydroxy-4-pregnene-3,20-dione; 18-Oxocorticosterone; Aldocorten; Aldocortene; Aldocortin; Electrocortin; Elektrocortin; NSC 73856; Reichstein X. Grades: Highly Purified. CAS No. 52-39-1. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C??H??O?, Molecular Weight: 360.44. US Biological Life Sciences.
Worldwide
Aldosterone
Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 52-39-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-113313.
Aldosterone
An adrenocortical steroid which exerts regulatory influence on metabolism of electrolytes and water. Synonyms: (11β)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al; 11β,21-Dihydroxypregn-4-ene-3,18,20-trione; 18-Formyl-11β,21-dihydroxy-4-pregnene-3,20-dione; 18-Oxocorticosterone; Electrocortin; Aldocortin; Aldocorten. Grade: > 95%. CAS No. 52-39-1. Molecular formula: C21H28O5. Mole weight: 360.45.
Aldosterone
25mg Pack Size. Group: Bioactive Small Molecules, Biochemicals, Research Organics & Inorganics. Formula: C21H28O5. CAS No. 52-39-1. Prepack ID 12239606-25mg. Molecular Weight 360.44. See USA prepack pricing.
Aldosterone 18-Oxime 21-Acetate
Used in the preparation of Aldosterone, an adrenocortical steroid which exerts regulatory influence on metabolism of electrolytes and water. Group: Biochemicals. Alternative Names: Aldosterone Oxime 21-Acetate; (11 β)-21-(Acetyloxy)-11-hydroxy-3,20-dioxo-pregn-4-en-18-al 18-Oxime. Grades: Highly Purified. CAS No. 74220-49-8. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Aldosterone 21-Acetate
Aldosterone derivative. Group: Biochemicals. Alternative Names: Aldosterone 21-Monoacetate; (11 β)-21-(Acetyloxy)-11,18-epoxy-18-hydroxy-pregn-4-ene-3,20-dione. Grades: Highly Purified. CAS No. 2827-21-6. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
Aldox
Aldox. Group: Biochemicals. Alternative Names: N- [3- (Dimethylamino) propyl] tetradecanamide; Dimethylaminopropyl myristamide; Lexamine M 13. Grades: Highly Purified. CAS No. 45267-19-4. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C19H40N2O. US Biological Life Sciences.
Worldwide
Aldoxorubicin
Aldoxorubicin (INNO-206) is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), which is released from albumin under acidic conditions. Aldoxorubicin (INNO-206) has potent antitumor activities in various cancer cell lines and in murine tumor models. Uses: Scientific research. Category: Signaling pathways. Alternative Names: INNO-206; DOXO-EMCH. CAS No. 1361644-26-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16261.
Aldumastat (GLPG1972; S201086) is a potent, seletive and orally active ADAMTS-5 (IC50=19 nM) inhibitor, and has 8-fold seletivity over ADAMTS-4 (IC50=156 nM). Aldumastat has anticatabolic activity and is used for osteoarthritis research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GLPG1972; S201086. CAS No. 1957278-93-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137430.
ALE-0540
ALE-0540 is a novel nonpeptidic molecule that inhibits the binding of NGF to tyrosine kinase (Trk) A or both p75 and TrkA, as well as signal transduction and biological responses mediated by TrkA receptors. Synonyms: 1H-Benz(de)isoquinoline-1,3(2H)-dione, 2-((2-hydroxyethyl)amino)-5-nitro-. Grade: >95.0%. CAS No. 234779-34-1. Molecular formula: C14H11N3O5. Mole weight: 301.26.
Alectinib
Alectinib (CH5424802; RO5424802; RG7853) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CH5424802; RO5424802; RG7853. CAS No. 1256580-46-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-13011.
Alectinib
Alectinib, marketed as Alecensa, is an oral drug that blocks the activity of anaplastic lymphoma kinase (ALK) and is used to treat non-small-cell lung cancer (NSCLC). Alectinib has a low potential for interactions. While it is metabolised by the liver enzyme CYP3A4, and blockers of this enzyme accordingly increase its concentrations in the body, they also decrease concentrations of the active metabolite M4, resulting in only a small overall effect. Conversely, CYP3A4 inducers decrease alectinib concentrations and increase M4 concentrations. Interactions via other CYP enzymes and transporter proteins cannot be excluded but are unlikely to be of clinical significance. Synonyms: CH-5424802; CH5424802; CH 5424802; AF-802; RG-7853; RO5424802. Grade: ≥95%. CAS No. 1256580-46-7. Molecular formula: C30H34N4O2. Mole weight: 482.62.
Alectinib
Alectinib. Uses: For analytical and research use. Alternative Names: 9-ethyl-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. CAS No. 1256580-46-7. Molecular formula: C30H34N4O2. Mole weight: 482.62. Catalog: APB1256580467.
Alectinib
Alectinib is a potent ALK inhibitor. Applications: Anticancer. Category: Anti-tumor apis. CAS No. 1256580-46-7. Product ID: API1256580467. Molecular formula: C30H34N4O2. Mole weight: 482.62. EINECS: 821-541-6.
Alectinib (CH5424802)
Alectinib is a potent ALK inhibitor with IC50 of 1.9 nM in cell-free assays, sensitive to L1196M mutation and higher selectivity for ALK than PF-02341066, NVP-TAE684 and PHA-E429. Group: Inhibitors. Alternative Names: AF-802, RG-7853,CH5424802. CAS No. 1256580-46-7. Pack Sizes: 5mg. Product ID: S2762. Formula: C30H34N4O2. Smiles: CCC1=CC2=C(C=C1N3CCC(CC3)N4CCOCC4)C(C5=C(C2=O)C6=C(N5)C=C(C=C6)C#N)(C)C. Storage Conditions: 2 years -80 in solvent.
United States; Europe
Alectinib-d8
Alectinib-d8 is the deuterium labeled Alectinib. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CH5424802-d8; RO5424802-d8; AF802-d8. CAS No. 1256585-15-5. Pack Sizes: 1 mg. Product ID: HY-13011S.
Alectinib Hydrochloride
Alectinib (CH5424802; RO5424802; RG7853) Hydrochloride is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride. CAS No. 1256589-74-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13011A.
Alectinib Hydrochloride (Standard)
Alectinib (Hydrochloride) (Standard) is the analytical standard of Alectinib (Hydrochloride). This product is intended for research and analytical applications. Alectinib Hydrochloride (CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CH5424802 Hydrochloride (Standard); RO5424802 Hydrochloride (Standard); AF-802 Hydrochloride (Standard). CAS No. 1256589-74-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13011AR.
Alectinib Impurity 1
Alectinib Impurity 1. Uses: For analytical and research use. Alternative Names: 9-ethyl-8-(4-((2-hydroxyethyl)amino)piperidin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. CAS No. 1256585-04-2. Molecular formula: C28H32N4O2. Mole weight: 456.58. Catalog: APB1256585042.
Alectinib Impurity 10
Alectinib Impurity 10. Uses: For analytical and research use. Alternative Names: 6-cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylic acid. CAS No. 1256584-78-7. Molecular formula: C30H36N4O3. Mole weight: 500.63. Catalog: APB1256584787.
Alectinib Impurity 11
Alectinib Impurity 11. Uses: For analytical and research use. Alternative Names: 9-ethyl-6,6-dimethyl-11-oxo-8-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. CAS No. 1256584-81-2. Molecular formula: C28H29N3O3. Mole weight: 455.55. Catalog: APB1256584812.
Alectinib Impurity 12
Alectinib Impurity 12. Uses: For analytical and research use. Alternative Names: 9-ethyl-6,6-dimethyl-11-oxo-8-(4-oxopiperidin-1-yl)-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. CAS No. 1256584-83-4. Molecular formula: C26H25N3O2. Mole weight: 411.50. Catalog: APB1256584834.
Alectinib Impurity 13
Alectinib Impurity 13. Uses: For analytical and research use. Alternative Names: 9-ethyl-8-iodo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. CAS No. 1256584-80-1. Molecular formula: C21H17IN2O. Mole weight: 440.28. Catalog: APB1256584801.
Alectinib Impurity 14
Alectinib Impurity 14. Uses: For analytical and research use. Alternative Names: 2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid. CAS No. 1256584-73-2. Molecular formula: C12H15IO2. Mole weight: 318.15. Catalog: APB1256584732.
Alectinib Impurity 15
Alectinib Impurity 15. Uses: For analytical and research use. Alternative Names: 2-(4-ethylphenyl)-2-methylpropanoic acid. CAS No. 1247119-83-0. Molecular formula: C12H16O2. Mole weight: 192.25. Catalog: APB1247119830.
Alectinib Impurity 16
Alectinib Impurity 16. Uses: For analytical and research use. Alternative Names: 2-methyl-2-(4-vinylphenyl)propanoic acid. CAS No. 1256584-72-1. Molecular formula: C12H14O2. Mole weight: 190.24. Catalog: APB1256584721.
Alectinib Impurity 2
Alectinib Impurity 2. Uses: For analytical and research use. Alternative Names: 8-(4-aminopiperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. CAS No. 1256585-14-4. Molecular formula: C26H28N4O. Mole weight: 412.53. Catalog: APB1256585144.
Alectinib Impurity 2
Alectinib Impurity 2. Uses: For analytical and research use. Molecular formula: C30H29D5N4O2. Mole weight: 487.66. Catalog: APB12026.
Alectinib Impurity 3
Alectinib Impurity 3. Uses: For analytical and research use. Alternative Names: 2-((1-(3-cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)piperidin-4-yl)(2-hydroxyethyl)amino)acetic acid. Molecular formula: C30H34N4O4. Mole weight: 514.62. Catalog: APB03242.
Alectinib Impurity 4
Alectinib Impurity 4. Uses: For analytical and research use. CAS No. 1256585-15-5. Molecular formula: C30H26D8N4O2. Mole weight: 490.68. Catalog: APB1256585155.
Alectinib Impurity 4
Alectinib Impurity 4. Uses: For analytical and research use. Alternative Names: 9-bromo-8-hydroxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. CAS No. 1256579-06-2. Molecular formula: C19H13BrN2O2. Mole weight: 381.22. Catalog: APB1256579062.
Alectinib Impurity 5
Alectinib Impurity 5. Uses: For analytical and research use. Alternative Names: tert-butyl 4-(4-ethyl-3-iodophenyl)-4-methyl-3-oxopentanoate. CAS No. 1256584-74-3. Molecular formula: C18H25IO3. Mole weight: 416.29. Catalog: APB1256584743.
Alectinib Impurity 6
Alectinib Impurity 6. Uses: For analytical and research use. Alternative Names: 6-bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one. CAS No. 1256578-99-0. Molecular formula: C13H15BrO2. Mole weight: 283.16. Catalog: APB1256578990.
Alectinib Impurity 7
Alectinib Impurity 7. Uses: For analytical and research use. Alternative Names: tert-butyl 6-cyano-2-(2-(4-ethyl-3-iodophenyl)propan-2-yl)-1H-indole-3-carboxylate. CAS No. 1256584-75-4. Molecular formula: C25H27IN2O2. Mole weight: 514.40. Catalog: APB1256584754.
Alectinib Impurity 8
Alectinib Impurity 8. Uses: For analytical and research use. Alternative Names: tert-butyl 6-cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylate. CAS No. 1256698-41-5. Molecular formula: C34H44N4O3. Mole weight: 556.74. Catalog: APB1256698415.
Alectinib Impurity 8 (Hydrochloride)
Alectinib Impurity 8 (Hydrochloride). Uses: For analytical and research use. Alternative Names: tert-butyl 6-cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylate hydrochloride. CAS No. 1256584-77-6. Molecular formula: C34H44N4O3·HCl. Mole weight: 593.21. Catalog: APB1256584776.
Alectinib Impurity 9
Alectinib Impurity 9. Uses: For analytical and research use. Alternative Names: tert-butyl 6-cyano-2-(2-(4-ethyl-3-iodophenyl)propan-2-yl)benzofuran-3-carboxylate. CAS No. 1256585-29-1. Molecular formula: C25H26INO3. Mole weight: 515.38. Catalog: APB1256585291.
Alefacept (BG 9273) is a human lymphocyte function-associated antigen 3/immunoglobulin 1 fusion protein. Alefacept can be used for the research of chronic plaque psoriasis[1]. Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: BG 9273; Human LFA 3IgG fusion protein; LFA 3TIP. CAS No. 222535-22-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99429.