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| Product | Description | |
|---|---|---|
| Alogliptin Impurity D | Alogliptin Impurity D. Uses: For analytical and research use. Alternative Names: 2-(2,5-dioxopyrrolidin-1-yl)-2-methylpropanenitrile. Molecular formula: C8H10N2O2. Mole weight: 166.18. Catalog: APB02486. |  |
| Alogliptin Impurity E | Alogliptin Impurity E. Uses: For analytical and research use. Alternative Names: 2-(2-cyano-2-methylpropyl)benzonitrile. Molecular formula: C12H12N2. Mole weight: 184.24. Catalog: APB02487. | |
| Alogliptin Impurity O | Alogliptin Impurity O. Uses: For analytical and research use. CAS No. 655-63-0. Molecular formula: C8H5Br2N. Mole weight: 274.94. Catalog: APB655630. | |
| Alogliptin Related Compound 15 | A metabolite of Aloesin. Synonyms: Alogliptin Impurity C. Grade: > 95%. CAS No. 1108731-49-2. Molecular formula: C20H23N5O3. Mole weight: 381.44. |  |
| Alogliptin Related Compound 18 | A metabolite of Aloesin. Grade: > 95%. CAS No. 1430222-09-5. Molecular formula: C26H23N5O4. Mole weight: 469.5. | |
| Alogliptin Related Compound 22 | A metabolite of Aloesin. Synonyms: 2-Dibromomethyl-benzonitrile. Grade: > 95%. CAS No. 655-63-0. Molecular formula: C8H5Br2N. Mole weight: 274.94. | |
| Alogliptin Related Compound 23 | A metabolite of Aloesin. Synonyms: N,N'-Bis(2'-cyanobenzyl)-6-chloro-2,4-dioxopyrimidine. Grade: > 95%. CAS No. 1618644-29-3. Molecular formula: C20H13ClN4O2. Mole weight: 376.81. | |
| Alogliptin Related Compound 24 | A metabolite of Aloesin. Synonyms: 2-[(6-Chloro-3-ethyl-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methyl]-benzonitrile. Grade: > 95%. CAS No. 1430222-06-2. Molecular formula: C14H12ClN3O2. Mole weight: 289.72. | |
| Alogliptin Related Compound 25 | Alogliptin Related Compound 25 is an impurity of alogliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor in the class of oral antidiabetic drugs. Synonyms: Alogliptin-1-oxo-1-de(piperidin-3-amine). Grade: 95%. CAS No. 1246610-72-9. Molecular formula: C13H11N3O3. Mole weight: 257.25. | |
| Alogliptin Related Compound 26 | A metabolite of Aloesin. Synonyms: N-Desmethyl,N-2(2-cyanobenzyl) Alogliptin. Grade: > 95%. CAS No. 865759-10-0. Molecular formula: C25H24N6O2. Mole weight: 440.51. | |
| Alogliptin Related Compound 27 | A metabolite of Aloesin. Synonyms: 2-((6-Chloro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile. Grade: > 95%. CAS No. 865758-95-8. Molecular formula: C12H8ClN3O2. Mole weight: 261.67. | |
| Alogliptin Related Compound 29 | A metabolite of Aloesin. Synonyms: Loxoprofen acid. Grade: > 95%. CAS No. 1246610-74-1. Molecular formula: C23H29N5O4. Mole weight: 439.52. | |
| Alogliptin Related Compound 4 | A metabolite of Aloesin. Synonyms: 6-Despiperidinyl-6-(alogliptin-Namino-yl) Alogliptin. Grade: > 95%. CAS No. 1268836-55-0. Molecular formula: C31H30N8O4. Mole weight: 578.64. | |
| Alogliptin Related Compound 5 | A metabolite of Aloesin. Synonyms: Alogliptin Related Compound 5 (Racemic). Grade: > 95%. CAS No. 1338677-76-1. Molecular formula: C10H16N4O2. Mole weight: 224.26. | |
| Aloin A | Aloin A. Group: Biochemicals. CAS No. 1415-73-2. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| Aloin-A | Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI)[1][2][3][4]. Uses: Scientific research. Category: Natural products. Alternative Names: Barbaloin-A. CAS No. 1415-73-2. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-N0123. |  |
| Aloin A (Barbaloin A) | Aloin A (Barbaloin A). Group: Biochemicals. Alternative Names: Barbaloin A. Grades: Plant Grade. CAS No. 1415-73-2. Pack Sizes: 20mg. Molecular Formula: C21H22O9, Molecular Weight: 418.394. US Biological Life Sciences. | Worldwide |
| Aloin-A (Standard) | Aloin (Standard) is the analytical standard of Aloin. This product is intended for research and analytical applications. Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Barbaloin-A (Standard). CAS No. 1415-73-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0123R. | |
| Aloin B | Aloin B. Group: Biochemicals. CAS No. 28371-16-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Aloin B | Aloin B (Isobarbaloin) is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor with an IC50 of 16.08 μM (hydrolytic activity) and 17.51 μM (deubiquitinase activity). Aloin B is metabolized by rat intestinal flora into aloe-emodin-9-anthrone to exert laxative effects. Aloin B inhibits TPA (HY-18739)-induced ear edema, putrescine elevation, and tumor promotion in mouse skin. Aloin B can be used in research related to anti-inflammation, tumor promotion inhibition, coronavirus disease 2019 (COVID-19) and constipation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Isobarbaloin. CAS No. 28371-16-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0886. | |
| Aloin B | Aloin B. Uses: For analytical and research use. Category: Herbal medicinal products standards. CAS No. 28371-16-6. Mole weight: 418.39. Catalog: AP28371166. | |
| Aloin B (Isobarbaloin) | Aloin B (Isobarbaloin). Group: Biochemicals. Alternative Names: Isobarbaloin; β-Barbaloin. Grades: Plant Grade. CAS No. 28371-16-6. Pack Sizes: 20mg. Molecular Formula: C21H22O9, Molecular Weight: 418.398. US Biological Life Sciences. | Worldwide |
| Aloin (mixture of A&B) | Botanical Source: Group: Biochemicals. Alternative Names: Barbaloin, Socaloin, Ugandaloin, Jafaloin, Cafaloin. Grades: Plant Grade. CAS No. 8015-61-0. Pack Sizes: 20mg. US Biological Life Sciences. | Worldwide |
| Aloinoside A | 56645-88-6. Uses: Scientific research. Category: Signaling pathways. CAS No. 56645-88-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N12450. | |
| Aloinoside B | 11006-91-0. Uses: Scientific research. Category: Natural products. CAS No. 11006-91-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N12449. | |
| Aloin Peracetate | Aloin Peracetate. Group: Biochemicals. Alternative Names: (S)-1,5-Anhydro-1-C-[4,5,10-tris(acetyloxy)-2-[(acetyloxy)methyl]-9-anthracenyl]-D-glucitol Tetracetate. Grades: Highly Purified. CAS No. 64951-96-8. Pack Sizes: 50mg. Molecular Formula: C37H38O17, Molecular Weight: 754.69. US Biological Life Sciences. | Worldwide |
| Aloisine A | Aloisine a is a cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25, respectively). Uses: A potent and selective cdk and gsk-3 inhibitor. Synonyms: Aloisine A; 4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol. Grade: ≥98%. CAS No. 496864-16-5. Molecular formula: C16H17N3O. Mole weight: 267.33. | |
| Aloisine A RP107 | Aloisine A RP107. Group: Biochemicals. Alternative Names: RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine; 4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol. Grades: Highly Purified. CAS No. 496864-16-5. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C16H17N3O. US Biological Life Sciences. | Worldwide |
| Aloisine B | Aloisine B is a potent and selective CDK and GSK-3 inhibitor with highest affinity targets: Glycogen Synthase Kinase-3, Beta (Rattus norvegicus (rat)) (IC50=750.0 nM). Uses: A potent and selective cdk and gsk-3 inhibitor. Synonyms: 6-(4-chlorophenyl)-7-(propan-2-yl)-5H-pyrrolo[2,3-b]pyrazine; 6-phenyl[5H]pyrrolo[2,3-b]pyrazine (aloisine) 37; 6-(4-chlorophenyl)-7-isopropyl-5H-pyrrolo[2,3-b]pyrazine. Grade: ≥98%. CAS No. 496864-14-3. Molecular formula: C15H14ClN3. Mole weight: 271.75. | |
| Aloisine RP106 | A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk1/cyclin B, Cdk5/p35, and GSK-3 (IC50 = 700nM, 1.5 uM, and 920 nM, respectively). It is a derivative of the aloisines A and B, which competitively inhibit ATP binding to the catalytic subunit of CDKs and GSKs. Synonyms: RP106; 7-n-Butyl-6-(4-methoxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine. Grade: ≥98%. CAS No. 496864-15-4. Molecular formula: C17H19N3O. Mole weight: 281.4. | |
| Aloisine RP106 | Aloisine RP106. Group: Biochemicals. Alternative Names: RP106, 7-n-Butyl-6-(4-methoxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine. Grades: Highly Purified. CAS No. 496864-15-4. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C17H19N3O. US Biological Life Sciences. | Worldwide |
| Aloperine | Botanical Source: Group: Biochemicals. Grades: Plant Grade. CAS No. 56293-29-9. Pack Sizes: 20mg. US Biological Life Sciences. | Worldwide |
| Alose impurity 1 | Alose impurity 1. Uses: For analytical and research use. Molecular formula: C6H12O6. Mole weight: 180.16. Catalog: APB11510. | |
| Alosetron | Alosetron, an effective 5-HT3 receptor antagonist, could be commonly used against irritable bowel syndrome. Uses: Alosetron is an effective 5-ht3 receptor antagonist and could be commonly used against irritable bowel syndrome. Synonyms: Alosetron, GR 68755, GR68755, GR-68755, Lotronex; ALOSETRON2,3,4,5-Tetrahydro-5-methyl-2-((5-methyl-1H-imidazol-4-yl)methyl)-1H-pyrido(4,3-b)indol-1-one. Grade: 95%. CAS No. 122852-42-0. Molecular formula: C17H18N4O. Mole weight: 294.36. | |
| Alosetron | 25mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C17H18N4O ·HCl. CAS No. 122852-42-0. Prepack ID 85312341-25mg. Molecular Weight 330.81. See USA prepack pricing. |  |
| Alosetron | Alosetron (GR 68755) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GR 68755; GR 68755X. CAS No. 122852-42-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-70050A. | |
| Alosetron-[d3] | Alosetron-[d3] is the labelled analogue of Alosetron, which is a 5-HT3 receptor antagonist used in the treatment of irritable bowel syndrome (IBS). Synonyms: Alosetron D3; 2,3,4,5-Tetrahydro-5-(methyl-d3)-2-[(4-methyl-1H-imidazol-5-yl)methyl]-1H-pyrido[4,3-b]indol-1-one; Lotronex-d3; 5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,3-b]indol-1-one-d3. Grade: 98% by HPLC. CAS No. 1190043-13-0. Molecular formula: C17H15D3N4O. Mole weight: 297.37. | |
| Alosetron-[d3] Hydrochloride | Alosetron-[d3] Hydrochloride is the labelled analogue of Alosetron Hydrochloride, which is a 5-HT3 receptor antagonist used in the treatment of irritable bowel syndrome (IBS). Uses: The hydrochloride salt form of isotope labelled alosetrone. Synonyms: Alosetron-d3 Hydrochloride; 2,3,4,5-Tetrahydro-5-(methyl-d3)-2-[(4-methyl-1H-imidazol-5-yl)methyl]-1H-pyrido[4,3-b]indol-1-one Hydrochloride; GR 68755-d3; GR 68755X-d3; Lotronex-d3 Hydrochloride. Grade: >95%. CAS No. 1189919-71-8. Molecular formula: C17H15D3N4O.HCl. Mole weight: 333.83. | |
| Alosetron HCl | The hydrochloride salt form of Alosetron which is an effective 5-HT3 receptor antagonist and could be commonly used against irritable bowel syndrome. Uses: The hydrochloride salt form of alosetron which is an effective 5-ht3 receptor antagonist and could be commonly used against irritable bowel syndrome. Synonyms: 2,3,4,5-Tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-1H-pyrido[4,3-b]indol-1-one Hydrochloride. Grade: > 95%. CAS No. 122852-69-1. Molecular formula: C17H18N4O. HCl. Mole weight: 330.81. | |
| Alosetron hydrochloride | Alosetron hydrochloride. Alternative Names: Alosetron hydrochloride. CAS No. 122852-69-1. Purity: 98%. Product ID: ACM122852691. Molecular formula: C17H19ClN4O. Mole weight: 330.81. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| Alosetron Hydrochloride | Serotonin 5HT3-receptor antagonist. Used in treatment of irritable bowel syndrome. Group: Biochemicals. Alternative Names: 2,3,4,5-Tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-1H-pyrido[4,3-b]indol-1-one Hydrochloride; GR 68755; GR 68755X; Lotronex. Grades: Highly Purified. CAS No. 122852-69-1. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Alosetron Hydrochloride(1:X) | The hydrochloride salt form of Alosetron, a 5HT3-receptor antagonist, could be used against bowel syndrome. Uses: The hydrochloride salt form of alosetron is a 5ht3-receptor antagonist that could be used against bowel syndrome. Synonyms: GR 68755; GR 68755X; Lotronex; GR-68755; GR68755. Grade: 95%. CAS No. 132414-02-9. Molecular formula: C17H19ClN4O. Mole weight: 330.81. | |
| Alosetron N-β-D-Glucuronide | A derivative of Alosetron. Synonyms: 1-Deoxy-1-[4-methyl-5-[(1,3,4,5-tetrahydro-5-methyl-1-oxo-2H-pyrido[4,3-b]indol-2-yl)methyl]-1H-imidazol-1-yl]-β-D-glucopyranuronic Acid. Grade: > 95%. CAS No. 863485-56-7. Molecular formula: C23H26N4O7. Mole weight: 470.49. | |
| Alosetron (Z)-2-butenedioate | The maleic acid salt form of Alosetron which is an effective 5-HT3 receptor antagonist and could be commonly used against irritable bowel syndrome. Uses: The maleic acid salt form of alosetron which is an effective 5-ht3 receptor antagonist and could be commonly used against irritable bowel syndrome. Synonyms: (Z)-but-2-enedioicacid; 5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,3-b]indol-1-one; Alosetron((Z)-2-butenedioate); 122852-43-1; SCHEMBL1045; Alosetron(Z)-2-butenedioate. Grade: 95%. CAS No. 122852-43-1. Molecular formula: C21H22N4O5. Mole weight: 410.42. | |
| Alovudine | Alovudine (3'-Fluoro-3'-deoxythymidine) is a mtDNA synthesis inhibitor and a marker of DNA synthesis. Alovudine is less susceptible to inflammatory changes than 18F-Fluorodeoxyglucose (FDG) and thus is a better biomarker in pancreatic cancer. Alovudine shows anti-orthopoxvirus and anti-leukemic activity[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3'-Fluoro-3'-deoxythymidine; 3-Deoxy-3-fluorothymidine; FLT. CAS No. 25526-93-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1516. | |
| Alovudine Impurity 1 | Alovudine Impurity 1. Uses: For analytical and research use. Molecular formula: C10H13FN2O4. Mole weight: 244.22. Catalog: APB12366. | |
| Alovudine Impurity 2 | Alovudine Impurity 2. Uses: For analytical and research use. Molecular formula: C36H40N2O9. Mole weight: 644.72. Catalog: APB12367. | |
| ALOX15-IN-1 | ALOX15-IN-1 (compound 8b) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with IC50s of 0.04 and 2.06 μM for ALOX15 0rthologs linoleic acid (LA) and arachidonic acid (AA), respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2764818-24-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143787. | |
| Aloxistatin | Aloxistatin is an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain, which predicted to function against SARS-CoV-2 infection. Synonyms: L-trans-Epoxysuccinyl(OEt)-Leu-3-methylbutylamide; L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester; (2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-2-oxiranecarboxylic Acid Ethyl Ester; E 64c ethyl ester; E 64d; EP 453; EST; Loxistatin; NSC 694281; (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester. Grade: 98%. CAS No. 88321-09-9. Molecular formula: C17H30N2O5. Mole weight: 342.43. | |
| Aloxistatin | Aloxistatin (E64d) is a cell-permeable and irreversible broad-spectrum cysteine protease inhibitor. Aloxistatin (E64d) exhibits entry-blocking effect for MERS-CoV. Uses: Scientific research. Category: Signaling pathways. Alternative Names: E64d; E64c ethyl ester. CAS No. 88321-09-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-100229. | |
| Aloxistatin (E-64d) | Aloxistatin (E64d) is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity. The cysteine protease cathepsin L is required for SARS-CoV-2 viral entry, and aloxistatin treatment reduced cellular entry of SARS-CoV-2 pseudovirions by 92.3%. Group: Inhibitors. Alternative Names: E-64d. CAS No. 88321-09-9. Pack Sizes: 2mg. Product ID: S7393. Formula: C17H30N2O5. Smiles: CCOC(=O)C1C(O1)C(=O)NC(CC(C)C)C(=O)NCCC(C)C. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| Alpelisib | Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity, inhibiting PI3Kβ/γ/δ with low activity (IC50=250/290/1200 nM). Alpelisib demonstrates antitumor activity and specifically targets PIK3CA mutant tumors. Category: Active pharmaceutical ingredients. CAS No. 1217486-61-7. Product ID: API1217486617. Molecular formula: C19H22F3N5O2S. Mole weight: 441.47. |  |
| Alpelisib | Alpelisib Inhibitor. Uses: Scientific use. Product Category: T1921. CAS No. 1217486-61-7. |  |
| Alpelisib | Alpelisib (BYL-719) is an orally active PI3Kα-selective inhibitor that blocks the conversion of PIP2 to PIP3, thereby inhibiting pathways including PI3K/AKT/mTOR, MAPK/ERK, Notch and JAK-STAT. Alpelisib also induces apoptosis, G0/G1 phase arrest and senescence; it significantly inhibits the proliferation, self-renewal, stemness and epithelial-mesenchymal transition (EMT) of tumor cells, reduces cancer stem cell populations and decreases the expression of stem cell markers. Alpelisib not only enhances the sensitivity to Eribulin (HY-13442) and exerts a synergistic effect with Paclitaxel (HY-B0015), but may also induce drug resistance by upregulating the SGK3/GSK3β/β-catenin signaling pathway. Alpelisib can be applied to research related to breast cancer, gastric cancer and lipomas associated with PTEN hamartoma tumor syndrome[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BYL-719. CAS No. 1217486-61-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-15244. | |
| Alpelisib | Alpelisib, also known as BLY719, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BYL719 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents. Synonyms: BYL-719; BYL719; BYL 719; Alpelisib. CAS No. 1217486-61-7. Molecular formula: C19H22F3N5O2S. Mole weight: 441.473. | |
| Alpelisib (BYL719) | Alpelisib (BYL719) is a potent and selective PI3Kα inhibitor with IC50 of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ. Phase 2. Group: Inhibitors. CAS No. 1217486-61-7. Pack Sizes: 5mg. Product ID: S2814. Formula: C19H22F3N5O2S. Smiles: CC1=C(SC(=N1)NC(=O)N2CCCC2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Alpelisib, Free Base, 99+% | Alpelisib, also known as BYL719, is a potent and selective phosphatidylinositol-3 kinase [alpha] inhibitor. It inhibited P110[alpha], p110[beta], p110[delta], and p110[gamma] with IC50 values of 5 nM, 1.2 µM, 0.29 µM and 0.25 µM, respectively, in biochemical assays. It inhibited the Akt phosphorylation with IC50 values of 74 nM in Rat1-myr-p110[alpha] cells, 2.2 µM in Rat1-myr-p110[beta] cells, and 1.2 µM in Rat1-myr-p110[delta] cells. Furet P., et al. "Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation." Bioorg. Med. Chem. Lett. 23: 3741-3748 (2013). Group: Biochemicals. Alternative Names: BYL-719; NVP-BYL719; (S)-Pyrrolidine-1,2-dicarboxylic Acid 2-Amide 1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-pyridin-4-yl]thiazol-2-yl]amide; (2S) -N1- [4- methyl -5- [2- (2, 2, 2-tri fluoro -1, 1-di methyl ethyl ) -4-pyridinyl ] -2-thiazoly l ] -1, 2-pyrrolidinedicarboxami de . Grades: Highly Purified. CAS No. 1217486-61-7. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C19H22F3N5O2S, Molecular Weight: 441.47. US Biological Life Sciences. | Worldwide |
| Alpelisib hydrochloride | Alpelisib (BYL-719) hydrochloride is an orally active PI3Kα-selective inhibitor that blocks the conversion of PIP2 to PIP3, thereby inhibiting pathways including PI3K/AKT/mTOR, MAPK/ERK, Notch and JAK-STAT. Alpelisib hydrochloride also induces apoptosis, G0/G1 phase arrest and senescence; it significantly inhibits the proliferation, self-renewal, stemness and epithelial-mesenchymal transition (EMT) of tumor cells, reduces cancer stem cell populations and decreases the expression of stem cell markers. Alpelisib hydrochloride not only enhances the sensitivity to Eribulin (HY-13442) and exerts a synergistic effect with Paclitaxel (HY-B0015), but may also induce drug resistance by upregulating the SGK3/GSK3β/β-catenin signaling pathway. Alpelisib hydrochloride can be applied to research related to breast cancer, gastric cancer and lipomas associated with PTEN hamartoma tumor syndrome[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BYL-719 hydrochloride. CAS No. 1584128-91-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-15244A. | |
| Alpelisib hydrochloride | Alpelisib hydrochloride (BYL-719 hydrochloride) exhibits anticancer properties. As a potent and selective PI3Kα inhibitor with high oral bioavailability, it has IC50 values of 5 nM for p110α, 250 nM for p110γ, 290 nM for p110δ, and 1200 nM for p110β, indicating its efficacy in targeting enzymes involved in cancer cell proliferation. Category: Active pharmaceutical ingredients. CAS No. 1584128-91-5. Product ID: API1584128915. Molecular formula: C19H23ClF3N5O2S. Mole weight: 477.93. | |
| Alpelisib hydrochloride | Alpelisib hydrochloride shows antineoplastic activity. Alpelisib hydrochloride is a potent, orally active, and selective PI3Kα inhibitor with IC50s of 5 nM, 250 nM, 290 nM and 1200 nM for p110α, p110γ, p110δ, and p110β, respectively. Synonyms: BYL-719 hydrochloride. CAS No. 1584128-91-5. Molecular formula: C19H23ClF3N5O2S. Mole weight: 477.93. | |
| Alpelisib (Standard) | Alpelisib (Standard) is the analytical standard of Alpelisib. This product is intended for research and analytical applications. Alpelisib (BYL-719) is a potent, selective, and orally active PI3Kα inhibitor. Alpelisib (BYL-719) shows efficacy in targeting PIK3CA-mutated cancer. Alpelisib (BYL-719) also inhibits p110α/p110γ/p110δ/p110β with IC50s of 5/250/290/1200 nM, respectively. Antineoplastic activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BYL-719 (Standard). CAS No. 1217486-61-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15244R. | |
| alpha-1,3-Galactosyltransferase (a1,3GalT) | alpha-1,3-Galactosyltransferase (a1,3GalT) (GGTA1) catalyzes the generation of the α-gal glycan via the transfer of a galactose (Gal) in α1-3 linkage, from a uridyl-diphosphate (UDP) donor onto the N-acetyllactosamine (Galβ1,4GlcNAc-R) of glycoproteins. alpha-1,3-Galactosyltransferase (a1,3GalT) is responsible for the synthesis of the α-galactose (α-Gal) epitope found in most mammalian species[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GGTA1. CAS No. 128449-51-4. Pack Sizes: 1 U; 5 U. Product ID: HY-E70052. | |
| alpha-1,4-Galactosyltransferase (LgtC) | alpha-1,4-Galactosyltransferase (LgtC) (A4GALT) is a glycosphingolipid-specific glycosyltransferase. alpha-1,4-Galactosyltransferase (LgtC) transfers a galactose to the alpha-1,4 position of lactosylceramide to form globotriaosylceramide. alpha-1,4-Galactosyltransferase (LgtC) can be used for the synthesis of P1 blood group antigens[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: A4GALT. CAS No. 52725-57-2. Pack Sizes: 5 U; 25 U. Product ID: HY-E70047. | |
| Alpha-[1-(butylmethylamino)ethyl]-benzyl alcohol | Alpha-[1-(butylmethylamino)ethyl]-benzyl alcohol. Alternative Names: alpha-[1-(Butylmethylamino)ethyl]-benzyl alcohol. CAS No. 25394-31-4. Purity: 96%. Product ID: ACM25394314-1. Molecular formula: C14H23NO. Mole weight: 221.33852. IUPAC Name: 2-[butyl(methyl)amino]-1-phenylpropan-1-ol. Alfa Chemistry - ISO 9001:32057 Certified. | |
| alpha-(1-(Methyl(2-propynyl)amino)ethyl)benzyl alcohol hydrochloride | alpha-(1-(Methyl(2-propynyl)amino)ethyl)benzyl alcohol hydrochloride. CAS No. 92039-72-0. Product ID: ACM92039720. Molecular formula: C13H18ClNO. Mole weight: 239.74112. Alfa Chemistry - ISO 9001:32057 Certified. | |
| Alpha-[1-(methylpentylamino)ethyl]-benzyl alcohol | Alpha-[1-(methylpentylamino)ethyl]-benzyl alcohol. Alternative Names: alpha-[1-(Methylpentylamino)ethyl]-benzyl alcohol. CAS No. 25394-37-0. Product ID: ACM25394370-1. Molecular formula: C15H25NO. Mole weight: 235.3651. Alfa Chemistry - ISO 9001:32057 Certified. | |
| Alpha-(1-piperidinylmethyl)-4-(3,4,5-trimethoxybenzoyl)-1-piperazineet hanol dihydrochloride | Alpha-(1-piperidinylmethyl)-4-(3,4,5-trimethoxybenzoyl)-1-piperazineet hanol dihydrochloride. CAS No. 109376-99-0. Product ID: ACM109376990. Alfa Chemistry - ISO 9001:32057 Certified. | |
| Alpha-(2-(((1,1-dimethylethoxy)carbonyl)amino)ethyl)benzenepropanoic acid | Alpha-(2-(((1,1-dimethylethoxy)carbonyl)amino)ethyl)benzenepropanoic acid. Alternative Names: alpha-(2-(((1,1-Dimethylethoxy)carbonyl)amino)ethyl)benzenepropanoic acid;[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-benzenepropanoic acid. CAS No. 1015070-59-3. Purity: 96%. Product ID: ACM1015070593. Molecular formula: C16H23NO4. Mole weight: 293.35812. IUPAC Name: 2-benzyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid. Alfa Chemistry - ISO 9001:32057 Certified. | |
| alpha-(2,4-Dichlorophenyl)-(1H)-imidazole-1-ethanol | 25g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C11H10Cl2N2O. CAS No. 24155-42-8. Prepack ID 10348695-25g. Molecular Weight 257.12. See USA prepack pricing. | |
| alpha-(2,4-Dichlorophenyl)-alpha-((octylthio)methyl)-1H-imidazole-1-et hanol | alpha-(2,4-Dichlorophenyl)-alpha-((octylthio)methyl)-1H-imidazole-1-et hanol. CAS No. 83337-64-8. Product ID: ACM83337648. Alfa Chemistry - ISO 9001:32057 Certified. | |
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