A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Bithionol is an antibacterial, anthelmintic, and algaecide agent. Bithionol is also a potent inhibitor of soluble adenylyl cyclase through binding to the allosteric activator site (IC 50 : 4 μM) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 97-18-7. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-17592.
Bithionol
Bithionol is a clinically approved anti-parasitic drug. It has been shown to inhibit solid tumor growth in several preclinical cancer models. It caused dose-dependent cytotoxicity against all ovarian cancer cell lines. Uses: Bithionol is one of the biocides commonly used in metalworking fluids. Synonyms: Actamer; Bitin; CP 3438; CP-3438; CP3438; Lorothidol; NSC 47129; NSC-47129; NSC47129. Grades: >98%. CAS No. 97-18-7. Molecular formula: C12H6Cl4O2S. Mole weight: 356.05.
Bithionol sulfoxide
Bithionol sulfoxide is a clinically approved anti-parasitic drug. It has been shown to inhibit solid tumor growth in several preclinical cancer models. Synonyms: Bitin-S. Grades: >98%. CAS No. 844-26-8. Molecular formula: C12H6Cl4O3S. Mole weight: 372.05.
Bithionol sulfoxide
Bithionol sulfoxide. Group: Biochemicals. Grades: Highly Purified. CAS No. 844-26-8. Pack Sizes: 2g, 5g, 10g, 25g, 50g. US Biological Life Sciences.
Worldwide
Bitolterol
Bitolterol. Group: Biochemicals. Alternative Names: p-Toluic acid, 4-[2-(tert-Butylamino)-1-hydroxyethyl]-o-phenylene ester (8CI); 4-methyl-benzoic Acid 1,1'-[4-[2-[(1,1-Dimethylethyl)amino]-1-hydroxyethyl]-1,2-phenylene] Ester. Grades: Highly Purified. CAS No. 30392-40-6. Pack Sizes: 25mg. Molecular Formula: C28H31NO5, Molecular Weight: 461.55. US Biological Life Sciences.
Worldwide
Bitolterol-d9
Bitolterol-d9. Group: Biochemicals. Alternative Names: p-Toluic acid 4-[2-(tert-Butylamino)-1-hydroxyethyl]-o-phenylene ester-d9; 4-methyl-benzoic Acid 1,1'-[4-[2-[(1,1-Dimethylethyl)amino]-1-hydroxyethyl]-1,2-phenylene] Ester-d9. Grades: Highly Purified. Pack Sizes: 2.5mg. Molecular Formula: C28H22D9NO5, Molecular Weight: 470.6. US Biological Life Sciences.
Worldwide
Bitolterol mesylate
Bitolterol mesylate (WIN 37284) is a diester-type agonist amine bronchodilator without significant cardiac side effects [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Win 32784; Bitolterol methanesulfonate; S-1540 mesylate. CAS No. 30392-41-7. Pack Sizes: 5 mg. Product ID: HY-16103.
Bitopertin
Bitopertin is a potent, noncompetitive glycine reuptake inhibitor, inhibits glycine uptake at human GlyT1 with a concentration exhibiting IC50 of 25 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RG1678; RO4917838. CAS No. 845614-11-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10809.
Bitopertin
Bitopertin is a potent and noncompetitive glycine reuptake inhibitor (GlyT1). It is effective in reducing the negative symptoms when given in combination with second generation antipsychotics. It is currently in Phase III trials for the treatment of the negative symptoms of schizophrenia. Synonyms: RG-1678; RG1678; RG 1678; R-1678; R1678; R 1678; RO4917838; RO-4917838; RO 4917838; Bitopertin. Grades: >98%. CAS No. 845614-11-1. Molecular formula: C21H20F7N3O4S. Mole weight: 543.46.
Bitopertin R enantiomer
Bitopertin R enantiomer is the R enantiomer of Bitopertin, which is a potent and noncompetitive glycine reuptake inhibitor (GlyT1). Synonyms: RG1678 (R enantiomer); RG 1678 (R enantiomer); RG-1678 (R enantiomer); RO4917838 (R enantiomer). Grades: >98%. CAS No. 845614-12-2. Molecular formula: C21H20F7N3O4S. Mole weight: 543.46.
Bitoscanate
Bitoscanate is an organic chemical compound used in the treatment of hookworms. Uses: Used in the treatment of hookworms. Synonyms: Bitoscanate; 16842; Bitoscanatum; Hoe 16842; Phenylene thiocyanate; AI3-28258; HSDB 6435;; 1,4-Diisothiocyanatobenzene;1,4-Phenylene diisothiocyanate. Grades: ≥95%. CAS No. 4044-65-9. Molecular formula: C8H4N2S2. Mole weight: 192.26.
Bitter Melon Extract
Bitter melon extract is prepared from the bitter melon which grows in tropical areas, it is used as food as well as medicine, it looks ugly and tastes very bitter. Bitter melon extract powder is rich in Vitamin B, VitaminC, calcium, iron and so on. Bitter melon extract charantin is widely used for antidiabetic as insulin-like effect. Several scientific studies have demonstrated the hypoglycemic effect of bitter melon. Group: Others. Bitter Melon Extract; Momordica Charantia Linn. Cat No: EXTC-020.
Bitter Melon Powder & P.E. 10.1
Bitter Melon Powder & P.E. 10.1.
CA, FL & NJ
Bitter Orange Extract
Bitter Orange Extract. Applications: Used for health care products, dietary supplements, reducing cholesterol. Group: Others. Synonyms: Bitter Orange Extract; Citrus aurantium L. Purity: 4-10:1 By TLC. Appearance: Brown yellow fine powder. Storage: 2 years under well storage situation and stored away from direct sun light. Source: Fruit. Species: Citrus aurantium L. Bitter Orange Extract; Citrus aurantium L.; plant extract. Pack: 20KG-25KG/Drum with double plastic bag of foodstuff inside. Cat No: EXTW-106.
Bitter Orange Extract
Bitter Orange Extract. Pack Sizes: 1 kg. Product ID: CDC10-0570. Category: Skin Protectant Ingredients. Product Keywords: Cosmetic Ingredients; Active Ingredients; Skin Protectant Ingredients; Bitter Orange Extract; CDC10-0570. Application: Soften and soothe the skin.
Bitter Orange Powder
Bitter Orange Powder.
CA, FL & NJ
Bitumen Cutback 8052-42-4
Bitumen Cutback - Surface Coatings. SUPPLIERS TO BUSINESS CUSTOMERS ONLY.
Biuret. Group: Biochemicals. Alternative Names: Allophanic acid amide; Carbamoylurea. Grades: Highly Purified. CAS No. 108-19-0. Pack Sizes: 50g, 100g, 250g, 500g, 1kg. Molecular Formula: NH2CONHCONH2. US Biological Life Sciences.
Worldwide
Biuret
100g Pack Size. Group: Organics. Formula: C2H5N3O2. CAS No. 108-19-0. Prepack ID 12779060-100g. Molecular Weight 103.08. See USA prepack pricing.
Biuret
Biuret. Uses: For analytical and research use. Group: Impurity standards. CAS No. 108-19-0. Molecular Formula: C2H5N3O2. Mole Weight: 103.08. Catalog: APB108190.
Biuret-15N3
Biuret-15N3 is the 15N3 labelled analogue of Biuret (B591500) which is used as a source of non-protein nitrogen in feed for ruminant. It is an impurity of urea based fertilisers as it has a poisonous effect on plants if present in high concentrations. Like peptide bonds, biuret forms violet-colored complexes with copper(II) ion in alkaline solution. This color change response is used to identify and quantify protein concentration (due to peptides present) and is known as biuret test. Group: Biochemicals. Grades: Highly Purified. CAS No. 287484-46-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C2H515N3O2, Molecular Weight: 106.06. US Biological Life Sciences.
Worldwide
Biuret 98+%
Biuret 98+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 25g, 100g, 250g, 1Kg. US Biological Life Sciences.
Worldwide
biuret amidohydrolase
Along with EC 3.5.2.15 (cyanuric acid amidohydrolase) and EC 3.5.1.54 (allophanate hydrolase), this enzyme forms part of thecyanuric-acid metabolism pathway, which degrades s-triazide herbicides, such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine], in bacteria.Urea-1-carboxylate rather than urea (as was thought previously) is the 2-nitrogen intermediate in cyanuric-acid metabolism in bacteria. The product, urea-1-carboxylate,can spontaneously decarboxylate under acidic conditions to form urea but, under physiological conditions, it can be converted into CO2 and ammonia by the action of EC 3.5.1.54. Group: Enzymes. Enzyme Commission Number: EC 3.5.1.84. CAS No. 95567-88-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4475; biuret amidohydrolase; EC 3.5.1.84; 95567-88-7. Cat No: EXWM-4475.
Biuret Powder, Laboratory Grade, 50 g
Biuret Powder, Laboratory Grade, 50 g. Notes: This powder is not used to make biuret. It is a positive control to let you know your biuret solution is working properly. Storage Code: Green; general chemical storage. Grades: chem-grade laboratory. Product ID: 848202. -- SOLD FOR EDUCATIONAL USE ONLY --
Biuret Reagent, Laboratory Grade, 100 mL
Characteristic: Blue. Notes: Solution changes from blue to violet in the presence of protein. Storage Code: White; corrosive. DOT Class: Corrosive. Grades: chem-grade laboratory. Product ID: 848211. -- SOLD FOR EDUCATIONAL USE ONLY --
Biuret Reagent, Laboratory Grade, 1 L
Characteristic: Blue. Notes: Solution changes from blue to violet in the presence of protein. Storage Code: White; corrosive. DOT Class: Corrosive. Grades: chem-grade laboratory. Product ID: 848214. -- SOLD FOR EDUCATIONAL USE ONLY --
Biuret Reagent, Laboratory Grade, 30 mL
Characteristic: Blue. Notes: Solution changes from blue to violet in the presence of protein. Storage Code: White; corrosive. DOT Class: Corrosive. Grades: chem-grade laboratory. Product ID: 848209. -- SOLD FOR EDUCATIONAL USE ONLY --
Biuret Reagent, Laboratory Grade, 4 L
Characteristic: Blue. Notes: Solution changes from blue to violet in the presence of protein. Storage Code: White; corrosive. DOT Class: Corrosive. Grades: chem-grade laboratory. Product ID: 848215. -- SOLD FOR EDUCATIONAL USE ONLY --
Biuret Reagent, Laboratory Grade, 500 mL
Characteristic: Blue. Notes: Solution changes color from blue to violet in the presence of protein. Storage Code: White; corrosive. DOT Class: Corrosive. Grades: chem-grade laboratory. Product ID: 848213. -- SOLD FOR EDUCATIONAL USE ONLY --
Biuret Solution
Biuret Solution. Pack Sizes: Milliliter Quantities: 6 x 500 ml, 6 x 1 L. Order Number: 62425.
Bivalirudin. Group: Biochemicals. Grades: Highly Purified. CAS No. 128270-60-0. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. US Biological Life Sciences.
Worldwide
Bivalirudin
Bivalirudin is a specific and reversible direct thrombin inhibitor (DTI). It is a synthetic congener of the naturally occurring drug hirudin. It is a DTI that overcomes many limitations seen with indirect thrombin inhibitors, such as heparin. It is a short, synthetic peptide that is potent, highly specific, and a reversible inhibitor of thrombin. It inhibits both circulating and clot-bound thrombin, while also inhibiting thrombin-mediated platelet activation and aggregation. It has a quick onset of action and a short half-life. It does not bind to plasma proteins (other than thrombin) or to red blood cells. Therefore, it has a predictable antithrombotic response. It does not require a binding cofactor such as antithrombin and does not activate platelets. Synonyms: Hirulog; Hirulog I; Angiomax; Hirulog-1; Hirulog1; Hirulog 1; BG8967; BG 8967; BG-8967; LS-172701; LS172701; LS 172701. Grades: > 95%. CAS No. 128270-60-0. Molecular formula: C98H138N24O33. Mole weight: 2180.32.
Bivalirudin
Bivalirudin, a peptide anticoagulant, is a direct thrombin inhibitor for anticoagulation in the setting of invasive cardiology, particularly percutaneous coronary intervention [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 128270-60-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1929.
Bivalirudin 12-20 Fragment Trifluoroacetic Acid Salt (Impurity)
Bivalirudin 12-20 Fragment Trifluoroacetic Acid Salt (Impurity). Group: Biochemicals. Alternative Names: L-Phenylalanyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-α-glutamyl-L-α-glutamyl-L-tyrosyl-L-leucine Trifluoroacetic Acid Salt. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C55H77N9O19 xC2HF3O2, Molecular Weight: 1264.26. US Biological Life Sciences.
Worldwide
Bivalirudin α-ASPA 9 Analog Trifluoroacetic Acid Salt (Impurity)
Bivalirudin Impurity 1 is an impurity of Bivalirudin which is an eminent anticoagulant, used to treat patients burdening heparin-induced thrombocytopenia. Grades: > 95%. CAS No. 72378-50-8. Molecular formula: C6H8N2O4. Mole weight: 172.14.
Bivalirudin Plus-Gly Fragment Trifluoroacetic Acid Salt (Impurity)
Bivalirudin TFA is a synthetic 20 residue peptide which reversibly inhibits thrombin. Uses: Scientific research. Group: Peptides. CAS No. 1191386-55-6. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15664.
Bivalirudin Trifluoroacetate
Bivalirudin is a specific and reversible bivalent direct thrombin inhibitor. Bivalirudin specifically binds to both the catalytic site and to the anion-binding exosite of circulating and clot-bound thrombin. Synonyms: Bivalirudin TFA; Bivalirudin TFA salt; H-D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH. Grades: >98%. Molecular formula: C100H138DF3N24O35. Mole weight: 2295.32.
Bivamelagon
MC-4R Agonist 2 (Example 1) is a MC4R agonist. MC-4R Agonist 2 can be used in the study of obesity, diabetes, inflammation, and erectile dysfunction [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MC-4R Agonist 2. CAS No. 2641595-54-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-153660.
Bivatuzumab
Bivatuzumab (Anti-CD44 Recombinant Antibody; BIWA 4) is a humanized monoclonal antibody directed against CD44v6. CD44v6 could acts as a sarcoma target for CAR-redirected CIK cells [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BIWA 4; Anti-CD44 Recombinant Antibody. CAS No. 214559-60-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99281.
BIX
BIX is a BiP (Hsp70-5) ER chaperone inducer that induces BiP expression in vitro and in vivo. BIX protects against ER-stress induced cell death in neuronal and retinal cell lines, and also protects against ischaemia-induced hippocampal cell death in vivo. Synonyms: 2-(3,4-Dihydroxyphenyl)-2-oxoethyl ester thiocyanic acid; Thiocyanic acid,2-(3,4-dihydroxyphenyl)-2-oxoethyl ester. Grades: ≥98% by HPLC. CAS No. 101714-41-4. Molecular formula: C9H7NO3S. Mole weight: 209.22.
BIX
BIX. Group: Biochemicals. Grades: Purified. CAS No. 101714-41-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
BIX 01294
Selective and cell permeable G9a histone lysine methyltransferase (HMTase) inhibitor. Pluripotent stem cell inducer. Group: Biochemicals. Alternative Names: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-4-quinazolinamine. Grades: Highly Purified. CAS No. 935693-62-2. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C28H38N6O2. US Biological Life Sciences.
Worldwide
BIX-01294
BIX-01294, a diazepin-quinazolinamine derivative, is a selective inhibitor of G9a histone methyl transferase (G9a HMTase) that impairs G9a HMTase and generation of H3K9me2 in vitro. It does not compete with cofactor S-adenosyl-methionine. It enhances reprogramming efficiency of neural progenitor cells to the same levels as when four transcription factors (Oct4, Klf4, Sox2 and c-Myc) were introduced to somatic cells for generation of induced pluripotent stem cells. It may replace the requirement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS). Synonyms: BIX-01294; BIX 01294; BIX01294. Grades: >98%. CAS No. 935693-62-2. Molecular formula: C28H38N6O2. Mole weight: 490.64.
BIX01294 hydrochloride hydrate
Histone methyltransferases (HMT) are histone-modifying enzymes (e.g., histone-lysine N-methyltransferases and histone-arginine N-methyltransferases) that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. BIX 01294 is a diazepin-quinazolinamine derivate and G9a histone methyltransferase inhibitor with IC50 of 1.9 μM and GLP inhibitor with IC50 of 0.7 μM. It less effectively inhibits the HMTase G9a-like protein and has no effect on other known HMTases. BIX 01294 was reported to function by blocking the histone binding sites. It modulates the epigenetic status of chromatin and has been used to improve the reprogramming efficiency of iPSC generation. Synonyms: BIX 01294; BIX-01294. Grades: ≥98%. CAS No. 1808255-64-2. Molecular formula: C28H38N6O2·3HCl·xH2O. Mole weight: 600.
BIX 01294 trihydrochloride
BIX 01294 is a G9a histone methyltransferase inhibitor. It enhances the induction of pluripotent stem cells from somatic cells in vitro. BIX-01294 trihydrochloride induces necroptosis and autophagy. Synonyms: BIX 01294 trihydrochloride; BIX-01294; N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine trihydrochloride. Grades: >98%. CAS No. 1392399-03-9. Molecular formula: C28H41Cl3N6O2. Mole weight: 600.02.
BIX 01294 Trihydrochloride
G9a-like protein and G9a histone lysine methyltransferase (HMTase) inhibitor that H3K9me2 chromatin levels modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro. Group: Biochemicals. Alternative Names: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine Trihydrochloride. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
BIX-01338 hydrate
BIX-01338 hydrate is a histone lysine methyltransferase inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 1228184-65-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12991A.
BIX02188
BIX02188. Group: Biochemicals. Alternative Names: 3- [ [ [3- [ (Dimethylamino) methyl] phenyl] amino] phenylmethylene] -2, 3-dihydro-2-oxo-1H-indole-6-carboxamide. Grades: Highly Purified. CAS No. 1094614-84-2. Pack Sizes: 10mg. Molecular Formula: C25H24N4O2, Molecular Weight: 412.48. US Biological Life Sciences.
Worldwide
BIX-02188
BIX02188 is a potent MEK5-selective inhibitor with an IC50 of 4.3 nM. BIX02188 inhibits ERK5 catalytic activity, with an IC50 of 810 nM. Synonyms: BIX02188; BIX-02188; BIX 02188. CAS No. 334949-59-6. Molecular formula: C25H24N4O2. Mole weight: 412.493.
BIX02189
BIX02189. Group: Biochemicals. Alternative Names: 3- [ [ [3- [ (Dimethylamino) methyl] phenyl] amino] phenylmethylene] -2, 3-dihydro-N, N-dimethyl-2-oxo-1H-indole-6-carboxamide. Grades: Highly Purified. CAS No. 1094614-85-3. Pack Sizes: 5mg. Molecular Formula: C27H28N4O2, Molecular Weight: 440.54. US Biological Life Sciences.
Worldwide
BIX 02189
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. Synonyms: BIX02189; BIX-02189; (Z)-3- ( (3- ( (dimethylamino)methyl)phenylamino) (phenyl)methylene)-N, N-dimethyl-2-oxoindoline-6-carboxamide. Grades: >98%. CAS No. 1094614-85-3. Molecular formula: C27H28N4O2. Mole weight: 440.54.
BIX 02189
BIX 02189. Group: Biochemicals. Grades: Purified. CAS No. 1265916-41-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
BIX 02565
BIX 02565, a RSK2 inhibitor, has also been found to significanltly influence sorts of adrenergic receptor subtypes involved in ascular tone and cardiac function. IC50: 1.1 nM (RSK2). Uses: Bix 02565 is a rsk2 inhibitor that has also been found to significanltly influence sorts of adrenergic receptor subtypes involved in ascular tone and cardiac function. Synonyms: BIX 02565; BIX02565; CHEMBL1933288; BIX02565; GTPL8039; SCHEMBL1980595; BDBM50360301. Grades: 97%. CAS No. 1311367-27-7. Molecular formula: C26H30N6O2. Mole weight: 458.56.
Bixalomer
Bixalomer. Uses: For analytical and research use. Group: Impurity standards. CAS No. 851373-13-2. Molecular Formula: C19H45ClN6O. Mole Weight: 409.06. Catalog: APB851373132.
Bixin
Bixin (BX), isolated from the seeds of Bixa orellana , is a carotenoid, possessing anti-inflammatory, anti-tumor and anti-oxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation and reactive oxygen species ( ROS ) generation [1]. Uses: Scientific research. Group: Natural products. CAS No. 6983-79-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N6884.
Bixin
Bixin. Group: Biochemicals. Alternative Names: 6-Methyl hydrogen (9Z)-6,6'-diapocarotene-6,6'-dioate. Grades: Highly Purified. CAS No. 6983-79-5. Pack Sizes: 1mg, 2mg, 5mg. US Biological Life Sciences.
Worldwide
Bixin min 90%
1g Pack Size. Group: Aroma Chemicals, Research Organics & Inorganics, Stains & Indicators. Formula: C25H30O4. CAS No. 6983-79-5. Prepack ID 45995458-1g. Molecular Weight 394.5. See USA prepack pricing.
BIX NHE1 inhibitor
BIX NHE1 inhibitor is a potent and selective NHE1 inhibitor (IC50 = 31 nM). It attenuates ischemic damage in an ischemia reperfusion injury isolated rat heart model ex vivo, attenuates phenylephrine-induced cardiomyocyte hypertrophy in vitro. Synonyms: BI-9627; BI 9627; BI9627; 4-(1-Acetyl-4-piperidinyl)-N-(aminoiminomethyl)-3-(trifluoromethyl)benzamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1204329-34-9. Molecular formula: C16H19F3N4O2.HCl. Mole weight: 392.8.
Bizelesin
Bizelesin is a synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting DNA replication and RNA synthesis. Bizelesin also enhances p53 and p21 induction and triggers G2/M cell-cycle arrest, resulting in cell senescence without apoptosis. Uses: Antineoplastic agents, alkylating. Synonyms: U-77779; U 77779; U77779; NSC-615291; N,N'-Bis[2-[[(1S)-1-(chloromethyl)-1,6-dihydro-5-hydroxy-8-methylbenzo[1,2-b:4,3-b']dipyrrol-3(2H)-yl]carbonyl]-1H-indol-5-yl]urea. CAS No. 129655-21-6. Molecular formula: C43H36Cl2N8O5. Mole weight: 815.71.
Bizine
Lysine-specific demethylase 1 (LSD1) is an epigenetic enzyme, which can oxidatively cleave methyl groups from monomethyl and dimethyl Lys4 of histone H3. Bizine is an LSD1 inhibitor, which is a phenelzine analog that inhibits lysine-specific demethylase 1 with ki of 59 nM. It is 23-fold, 63-fold, and >100-fold selective for LSD-1 over monoamine oxidase (MAO) A, MAOB, and LSD2, respectively. Synonyms: BSM-0353. Grades: ≥95%. CAS No. 1591932-50-1. Molecular formula: C18H23N3O. Mole weight: 297.4.
Bizine hydrochloride
Bizine hydrochloride is a potent and selective histone demethylase LSD1 inhibitor. Bizine can modulate bulk histone methylation in cancer cells and protect neurons exposed to oxidative stress, suggesting potential applications in neurodegenerative disease. Uses: Potential neurodegenerative disease therapy. Synonyms: N-[4-(2-hydrazinylethyl)phenyl]-4-phenylbutanamide hydrochloride. Grades: 98%. Molecular formula: C18H23N3O.HCl. Mole weight: 333.86.
BJB-2936
BJB-2936 is a novel inhibitor of FBPase 1, which plays a role in gluconeogenesis. Study showed that in KKAgamma and db/db mouse model, BJB-2936 significantly decreased the level of glucose and HbA1c. BJB-2936 is promisingly developed to be a drug for diabetes. Uses: The potential treatment of diabetes. Synonyms: BJB 2936; BJB2936.